UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
FORM 8-K
 
CURRENT REPORT
Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934
 
Date of Report (Date of earliest event reported): May 11, 2023
 
Femasys Inc.
(Exact name of registrant as specified in its charter)

Delaware
001-40492
11-3713499
(State or other jurisdiction of incorporation)
(Commission File Number)
(IRS Employer Identification No.)
   

3950 Johns Creek Court, Suite 100
 

Suwanee, Georgia   30024
(Address of principal executive offices)
 
(Zip Code)
 
(770) 500-3910
(Registrant’s telephone number, including area code)
 
n/a
(Former name or former address, if changed since last report)
 
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instructions A.2. below):

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
 
Securities registered pursuant to Section 12(b) of the Exchange Act:

Title of each class
 
Trading
Symbol(s)
 
Name of each exchange
on which registered
Common Stock, par value $0.001 per share
 
FEMY
 
The Nasdaq Stock Market LLC
 
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
 
Emerging growth company
 
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.



Item 2.02
Results of Operations and Financial Condition.
 
On May 11, 2023, Femasys Inc. (the “Company”) announced its financial results for the first quarter ended March 31, 2023 and provided a corporate update. A copy of the press release is being furnished as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.
 
The information in this Current Report on Form 8-K and Exhibit 99.1 attached hereto is intended to be furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.
 
Item 7.01
Regulation FD Disclosure

On May 11, 2023, the Company posted on its website an updated slide presentation, which is attached as Exhibit 99.2 to this Current Report on Form 8-K and incorporated by reference herein. Representatives of the Company will use the presentation in various meetings with investors, analysts and other parties from time to time.

The information furnished in this Item 7.01 and Exhibit 99.2 attached hereto is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act of 1933, as amended, except as may be expressly set forth by specific reference in such filing.

The Company expressly disclaims any obligation to update or revise any of the information contained in the corporate presentation.
 
Item 9.01
Financial Statements and Exhibits.
 
(d)
Exhibits.
 
Exhibit
No.
Description
 
 
Press Release of Femasys Inc. dated May 11, 2023
Femasys Inc. Corporate Presentation dated May 2023
104
Cover Page Interactive Data File (embedded within the Inline XBRL Document)


SIGNATURES
 
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 
Femasys Inc.
     
 
By:
/s/ Kathy Lee-Sepsick
 
Names: Kathy Lee-Sepsick
 
Title: Chief Executive Officer
   
Date: May 11, 2023  
 



Exhibit 99.1

Femasys Inc. Announces Financial Results for the First Quarter Ended
March 31, 2023

-Received regulatory approval for both FemaSeed® and FemCerv® products from Health Canada-
 
ATLANTA, May 11, 2023 -- Femasys Inc. (NASDAQ: FEMY), a biomedical company aiming to meet women's needs worldwide by developing a suite of product candidates that include minimally invasive, in-office technologies for reproductive health, today announced financial results for the first quarter ended March 31, 2023 and provided a corporate update.
 
“We continue to expand our commercial portfolio with Health Canada’s recent approval of both FemaSeed® and FemCerv® to improve the continuum of healthcare options for women,” said Kathy Lee-Sepsick, founder, president and chief executive officer of Femasys. “These two product approvals broaden our commercial offerings for women, with FemaSeed complementing FemVue®, our device that enables an in-office ultrasound assessment of the fallopian tubes as part of an infertility diagnosis prior to FemaSeed. Our goal is to further grow this synergistic product portfolio by exploring commercialization opportunities. These product offerings, along with our lead product candidate, FemBloc® permanent birth control, have the potential to address substantial, multi-billion-dollar global market segments by bringing safe, accessible options to women.”
 
First Quarter 2023 and Recent Corporate Highlights:


Recently, in April and May, Femasys received two product approvals, for both FemaSeed and FemCerv, from Health Canada, the Public Health Agency of Canada.


o
FemaSeed is the first-ever infertility solution designed to deliver sperm directly to where conception occurs. FemaSeed is a localized artificial insemination option designed to be less invasive and more affordable than assisted reproduction.


o
FemCerv is the first endocervical tissue sampler designed to collect and contain a tissue sample in a relatively pain-free manner to detect the presence of cancerous cells in a woman’s cervix. FemCerv is now commercially available the U.S. and Canada.


In April, Femasys raised $3.9 million in a registered direct offering priced at-the-market under Nasdaq rules. The offering closed on April 20, 2023. The proceeds from this offering will be used for working capital and general corporate purposes and is expected to extend Femasys’ cash runway into the second quarter of 2024.



In March, Femasys founder, president and chief executive officer, Kathy Lee-Sepsick, joined other thought leaders in Women’s Health for a panel discussion at SXSW 2023 discussing family planning and infertility options, during a panel, titled, The Future of Fertility: The Post-Roe Fertility Journey”.

First Quarter 2023 Financial Results

Research and development expenses increased by $116,376 to $1,537,439 for the three months ended March 31, 2023, from $1,421,063 for the three months ended March 31, 2022. The net increase largely consists of a $135,496 increase in compensation and related personnel costs primarily due to increasing costs associated with hiring and retaining personnel to support our clinical trial.
 
General and administrative expenses decreased by $132,218 to $1,315,137 for the three months ended March 31, 2023, from $1,447,355 for the three months ended March 31, 2022. The decrease was largely due to a decrease in salaries and related personnel costs, a decrease in facility and other overhead costs mainly for directors & officers (D&O) insurance, and a decrease in legal and certain professional costs.
 
Sales decreased by $27,421 to $293,984 for the three months ended March 31, 2023, from $321,405 for the same period last year. U.S. sales, however, increased by $30,624, or 11.6%, for the three months ended March 31, 2023; however, there were no international sales for the three months ended March 31, 2023, as compared to $58,045 reported for the same period last year, resulting in a decrease in sales. The decrease in sales resulted from the timing of international placed orders. Units sold in the U.S. increased by 7.1% for the three months ended March 31, 2023, as compared to the same period last year.

Sales and marketing expenses increased by $176,033 to $244,896 for the three months ended March 31, 2023, from $68,863 for the three months ended March 31, 2022. The net increase was primarily due to an increase in compensation and related personnel costs due to an increase in headcount and marketing costs to promote our commercial efforts.
 
Cost of sales decreased by $17,555 to $105,120 for the three months ended March 31, 2023, from $122,675 for the three months ended March 31, 2022. The decrease in cost of sales is mainly attributable to increased efficiency achieved through the purchase of new equipment and tooling which will enable us to reduce labor and material costs in certain manufacturing processes. Gross margin percentage was 64.2% for the three months ended March 31, 2023, as compared to 61.8% for the three months ended March 31, 2022. Gross margins improved due to higher U.S. sales which have lower cost of sales than international sales.


Net loss was $2,946,257 or $0.25 per basic and diluted share attributable to common stockholders, primarily reflecting the factors noted above, for the period ended March 31, 2023, compared to $2,883,030, or $0.24 per basic and diluted share attributable to common stockholders, for the same period ended March 31, 2022.

Cash and cash equivalents as of March 31, 2023 was $10,161,338. Based on our current operating plan, our existing cash and cash equivalents, along with the net proceeds from our recent financing are expected to be sufficient to fund our ongoing operations into the second quarter of 2024.


PART I. FINANCIAL INFORMATION

ITEM I. Financial Statements

FEMASYS INC.
Balance Sheets
(unaudited)

Assets
 
March 31, 2023
   
December 31,
2022
 
Current assets:
           
Cash and cash equivalents
 
$
10,161,338
     
12,961,936
 
Accounts receivable, net
   
123,955
     
77,470
 
Inventory, net
   
500,741
     
436,723
 
Other current assets
   
542,067
     
655,362
 
Total current assets
   
11,328,101
     
14,131,491
 
Property and equipment, at cost:
               
Leasehold improvements
   
1,195,637
     
1,195,637
 
Office equipment
   
99,344
     
99,344
 
Furniture and fixtures
   
419,303
     
419,303
 
Machinery and equipment
   
2,601,389
     
2,572,243
 
Construction in progress
   
406,588
     
413,843
 
     
4,722,261
     
4,700,370
 
Less accumulated depreciation
   
(3,344,400
)
   
(3,217,319
)
Net property and equipment
   
1,377,861
     
1,483,051
 
Long-term assets:
               
Lease right-of-use assets, net
   
239,351
     
319,557
 
Intangible assets, net of accumulated amortization
   
1,881
     
3,294
 
Other long-term assets
   
920,812
     
958,177
 
Total long-term assets
   
1,162,044
     
1,281,028
 
Total assets
 
$
13,868,006
     
16,895,570
 

(continued)


FEMASYS INC.
Balance Sheets
(unaudited)

Liabilities and Stockholders’ Equity
 
March 31, 2023
   
December 31,
2022
 
Current liabilities:
           
Accounts payable
 
$
526,764
     
510,758
 
Accrued expenses
   
535,417
     
456,714
 
Note payable
   
     
141,298
 
Clinical holdback - current portion
   
45,352
     
45,206
 
Lease liabilities – current portion
   
305,071
     
373,833
 
Total current liabilities
   
1,412,604
     
1,527,809
 
Long-term liabilities:
               
Clinical holdback - long-term portion
   
98,818
     
96,658
 
Lease liabilities – long-term portion
   
     
28,584
 
Total long-term liabilities
   
98,818
     
125,242
 
Total liabilities
   
1,511,422
     
1,653,051
 
Commitments and contingencies
               
Stockholders’ equity:
               
Common stock, $.001 par, 200,000,000 authorized, 11,989,796 shares issued and 11,872,573 outstanding as of March 31, 2023; and 11,986,927 shares issued and 11,869,704 outstanding as of December 31, 2022
   
11,990
     
11,987
 
Treasury stock, 117,223 shares
   
(60,000
)
   
(60,000
)
Warrants
   
567,972
     
567,972
 
Additional paid-in-capital
   
108,917,384
     
108,857,065
 
Accumulated deficit
   
(97,080,762
)
   
(94,134,505
)
Total stockholders’ equity
   
12,356,584
     
15,242,519
 
Total liabilities and stockholders' equity
 
$
13,868,006
     
16,895,570
 
 
The accompanying notes are an integral part of these unaudited financial statements.


FEMASYS INC.
Statements of Comprehensive Loss
(unaudited)

   
Three Months Ended March 31,
 
   
2023
   
2022
 
Sales
 
$
293,984
     
321,405
 
Cost of sales
   
105,120
     
122,675
 
Gross margin
   
188,864
     
198,730
 
Operating expenses:
               
Research and development
   
1,537,439
     
1,421,063
 
Sales and marketing
   
244,896
     
68,863
 
General and administrative
   
1,315,137
     
1,447,355
 
Depreciation and amortization
   
133,066
     
144,199
 
Total operating expenses
   
3,230,538
     
3,081,480
 
Loss from operations
   
(3,041,674
)
   
(2,882,750
)
Other income (expense):
               
Interest income
   
97,089
     
2,454
 
Interest expense
   
(1,672
)
   
(2,734
)
Other income (expense), net
   
95,417
     
(280
)
Net loss
 
$
(2,946,257
)
   
(2,883,030
)
                 
Net loss attributable to common stockholders, basic and diluted
 
$
(2,946,257
)
   
(2,883,030
)
Net loss per share attributable to common stockholders, basic and diluted
 
$
(0.25
)
   
(0.24
)
Weighted-average shares used in computing net loss per share attributable to common stockholders, basic and diluted
   
11,872,255
     
11,804,165
 

About FemaSeed®
 
FemaSeed is a first-of-its-kind infertility solution in development for directional intrauterine insemination that delivers sperm to the fallopian tube where conception occurs. It is intended to augment natural fertilization and provide a first-line treatment option for infertility. FemaSeed is designed to be less invasive and more affordable than assisted reproduction, such as in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

About FemBloc®
 
FemBloc is a first-of-its-kind, nonsurgical, non-implant, in-office solution in development for permanent birth control. It is intended to be a safer option for women by eliminating the need for anesthesia, incisions, and permanent implants. FemBloc has the potential to offer women a convenient and reliable option for permanent birth control.
In July 2022, Femasys hosted a Key Opinion Leader (KOL) Event with Paul D. Blumenthal, MD, MPH, Professor of Obstetrics and Gynecology at The Stanford University Medical Center to discuss FemBloc. To listen to a replay of this event, please click here.


About FemVue®
 
FemVue is the first FDA-cleared product that creates natural saline and air contrast and enables safe, reliable, and real time evaluation of the fallopian tubes with ultrasound. When performed with a uterine cavity assessment, a more comprehensive exam can be achieved from the comfort of the GYN’s office.

About FemCath®
 
FemCath is the first FDA-cleared product that allows for selective evaluation of the fallopian tubes by using in conjunction with the FemVue device. The ultrasound-based diagnostic test is part of an infertility evaluation, which is essential prior to any infertility treatment, including with our other biomedical solution in development, FemaSeed.

About FemCerv®
 
FemCerv is the first FDA-cleared product that allows for the capture and protection of a comprehensive 360-degree endocervical tissue sample in a relatively pain-free office visit. FemCerv features an expandable collection chamber that is exposed during sampling and closed during removal for containment of cervical cells and tissue.

About Femasys
 
Femasys Inc. is a biomedical company aiming to meet women's needs worldwide by developing a suite of products and product candidates that include minimally invasive, in-office technologies for reproductive health. Its two lead product candidates are FemBloc® permanent birth control and FemaSeed® localized directional insemination for infertility. The Company’s products currently marketed in the United States include FemVue® for fallopian tube assessment by ultrasound, which can be used in conjunction with FemCath®, an intrauterine catheter for selective evaluation of the fallopian tubes, and FemCerv®, an endocervical tissue sampler that is the first product of the technology platform for tissue sampling. To learn more, visit www.femasys.com or follow us on Twitter and LinkedIn.


Forward-Looking Statements
 
This press release contains forward-looking statements that are subject to substantial risks and uncertainties. Forward-looking statements can be identified by terms such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “pending,” “intend,” “believe,” “potential,” “hope,” or “continue” or the negative of these terms or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements are based on our current expectations and are subject to inherent uncertainties, risks and assumptions, many of which are beyond our control, difficult to predict and could cause actual results to differ materially from what we expect. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Factors that could cause actual results to differ include, among others: our ability to develop and advance our current product candidates and programs into, and successfully initiate, enroll and complete, clinical trials; the ability of our clinical trials to demonstrate safety and effectiveness of our product candidates and other positive results; estimates regarding the total addressable market for our product candidates; our business model and strategic plans for our products, technologies and business, including our implementation thereof; and those other risks and uncertainties described in the section titled "Risk Factors" in our Annual Report on Form 10-K for the year ended December 31, 2022 and other reports as filed with the SEC. Forward-looking statements contained in this press release are made as of this date, and Femasys undertakes no duty to update such information except as required under applicable law.

Contacts:
 
Investors
Chuck Padala
LifeSci Advisors, LLC
917-741-7792
[email protected]

Femasys Inc.
Investor Contact:
[email protected]

Media Contact:
[email protected]




Exhibit 99.2

 Disrupting Convention in Women’s Health Through Continuous Innovation  May 2023  Corporate Presentation  1 
 

 Forward-Looking Statements  This Presentation contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 relating to our business, operations and financial conditions, including but not limited to current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, results of clinical trials and other future conditions. Words such as, but not limited to, "anticipate", "believe", "could", "estimate", "expect", "intend", "may", "plan", "potential", "predict", "project", "should", "will", "would" or the negative of those terms, and similar expressions that convey uncertainty of future events or outcomes, identify forward-looking statements.  These forward-looking statements reflect management's beliefs and views with respect to future events and are based on estimates and assumptions as of the date of this Presentation and are subject to risks and uncertainties. Moreover, the Company operates in a very competitive and rapidly changing environment. New risks emerge from time to time. It is not possible for management to predict all risks, nor can the Company assess the impact of all factors on its business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements we may make. Given these uncertainties, you should not place undue reliance on these forward-looking statements. The Company qualifies all of the forward-looking statements in this Presentation by these cautionary statements. Except as required by law, the Company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise.  Statements contained herein are made as of the date of this Presentation unless stated otherwise, and neither this Presentation, nor any sale of securities, shall under any circumstances create an implication that the information contained herein is correct as of any time after such date or that the information will be updated or revisited to reflect information that subsequently becomes available or changes occurring after that date hereof.  Certain information contained in this Presentation relates to or is based statistical and other industry and market data obtained from independent industry publications and research, surveys and studies conducted by independent third parties as well as the Company's own estimates. The market data used in this Presentation involves a number of assumptions and limitations, and you are cautioned not to give undue weight to such data. Industry publications and third-party research, surveys and studies generally indicate that their information has been obtained from sources believed to be reliable, although they do not guarantee the accuracy or completeness of such information. The Company's estimates of the patient population with the potential to benefit from treatment with any product candidates the Company may develop include several key assumptions based on its industry knowledge, industry publications and third-party research, which may be based on a small sample size and may fail to accurately reflect the addressable patient population. While the Company believes that its internal assumptions are reasonable, no independent source has verified such assumptions.  This Presentation contains trademarks, trade names, or service marks belonging to other entities. The Company does not intend the use or display of other parties' trade names, trademarks or service marks to imply a relationship with, or endorsement or sponsorship of, or by these other parties.  2 
 

 Femasys: At-a-Glance  Who We Are  Financial Information  Femasys is a biomedical company aiming to meet women’s needs worldwide with a novel suite of products and product candidates that include minimally invasive, in-office technologies for reproductive health.  Headquarters: Suwanee, GA  Nasdaq: FEMY  IPO date: June 2021   Market Cap: $11.7M  (as of 05/10/23)     Cash: $10.2M  (as of 03/31/23 and does not include net proceeds of approximately $3.4M from April 2023 financing)  3 
 

 Investment Highlights  Biomedical Company Disrupting the Approaches to Women’s Health with Proprietary Diagnostic and Device Solutions in Development  Addressing Multi-Billion Dollar Global Market Opportunities in Infertility and Permanent Birth Control With Differentiated and Improved Approaches  Clear Reimbursement Path with Limited Competition Yields Improved Patient Care and Health Economics  4  Intellectual Property Portfolio with >150 Patents Globally  Cash Runway into Q2 2024  Woman-Founded and Led, Experienced Leadership Team with Concentrated Development Expertise  Commercial-Readiness Based on In-House CMC and Device Infrastructure; Audited Systems Allow for Risk Mitigation  Supply Chain Control; No Reliance on Third-Party Manufacturing  Mission  Differentiator  Foundation 
 

 Key Leadership  Experienced biotechnology and medical device professionals  Brian Drumheller  VP, Quality  30+ years of experience  Dan Currie  SVP, Operations  30+ years of experience  Jeremy Sipos  VP, Research & Development  20+ years of experience  Christine Thomas  SVP, Regulatory & Clinical Affairs  20+ years of experience  Terrell Pruitt  VP, Manufacturing  25+ years of experience  Edward Evantash, MD  Chief Medical Officer  20+ years of experience  Mary An Merchant, JD, PhD  VP Counsel, Intellectual Property  25+ years of experience  Dov Elefant  Chief Financial Officer  25+ years of experience  5  Kathy Lee-Sepsick  President, CEO, Founder  25+ years of experience 
 

 FemVue®️  Contrast-Generating Device  FemCath™️  Selective Delivery Catheter  FemaSeed®  Localized Directional Insemination  FemBloc®  Permanent Birth Control and Ultrasound Occlusion Confirmation  FemCerv®  Endocervical Tissue Sampler  FemaSeed®  FemBloc®  Product Candidates  Localized Directional Insemination  Research  Preclinical  Stage ISafety  Stage IIValidation  Stage IIIPivotal  DeNovo Clinical Study  PMA Clinical Study  Our Technologies in Development and Approved are Complimentary  TREATMENT  TREATMENT  Permanent Birth Control and Ultrasound Occlusion Confirmation  FemEMB™  DIAGNOSTIC  Endometrial   Tissue Sampler  Research  Preclinical  FemVue®️  Contrast-Generating Device  FemCath®️  Selective Delivery Catheter  Commercially Available Products  FemCerv®  Endocervical Tissue Sampler  DIAGNOSTIC  DIAGNOSTIC  DIAGNOSTIC  6 
 

 Strong Global Intellectual Property Portfolio  Our Patent Estate Encompasses Utility and Design  >150 patents globally  Directional Delivery (dual or single)   to Fallopian Tubes  Biopolymer Composition for Tubal Occlusion  Contrast Generating Ultrasound Visible  Tissue Sampling for Cancer Detection  FemBloc, FemaSeed, FemCath  FemBloc  FemVue  FemCerv  FemChec  7 
 

 Our Technologies Provide a Continuum of Care  In-office, minimally invasive solutions  Shared delivery platforms leverage existing skill sets   8 
 

 Femasys Unique In-Office Platform Technologies: Delivery Directed to Fallopian Tubes   9  I. Products isolate opening of fallopian tube(s) for precise delivery of materials   Selective catheter for sperm  Dual catheters for biopolymer  Selective catheter for contrast  Stage: Investigational for artificial insemination  Stage: Investigational for permanent birth control  No special skillset and no capital equipment  No cannulation of tube  Patents issued and pending  No anesthesia and no incisions  Stage: Commercially Available 
 

 Femasys Unique In-Office Platform Technologies:Diagnostic Contrast for Ultrasound   10  II. Products generate natural contrast for ultrasound evaluation of fallopian tubes  Assess patency for infertility diagnosis  Assess occlusion post FemBloc  Stage: Commercially Available  Stage: Investigational for confirmation test  Safe and affordable  No radiation or x-ray contrast dye  No referral and saves time  Patents issued and pending 
 

 Femasys Unique In-Office Platform Technologies:Tissue Sampling for Cancer Diagnosis   11  III. Products collect and contain comprehensive sample to maximize quality & quantity   Endocervical curettage for cervical cancer diagnosis  Endometrial biopsy for uterine cancer diagnosis  Stage: Commercially Available  Stage: R & D  Coming Soon  Safe and reliable  360° tissue capture  Virtually pain free  Patents issued 
 

 12  FemaSeed®  Localized Artificial Insemination  Developing the first and only first-line approach designed to deliver sperm directly where conception occurs  Designed to be more affordable than assisted reproduction   Companion Diagnostics FemVue® and FemCath®  Includes first in-office ultrasound diagnosis of fallopian tubes for infertility  Infertility Focused Portfolio 
 

 Infertility: Unmet Need (U.S. only)   >10M women struggle with infertility1  ~ 40-50% is due to male factor2  Despite advancements, there have been no new affordable options in decades.  13  https://www.cdc.gov/nchs/nsfg/key_statistics/i-keystat.htm  Kumar N, et al. (2015) Trends of male factor infertility, an important cause of infertility: A review of literature. J Hum Reprod Sci. 8(4): 191–196. doi: 10.4103/0974-1208.170370: 10.4103/0974-1208.170370.  Levine H, et al. (2023) Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries. Human Reproduction Update, Vol.29, No.2, pp. 157–176, 2023  Sperm counts worldwide have declined by >50%3 
 

 FemaSeed: Low Cost for Front-End of Infertility Treatment  FemaSeed  $$  Traditional IUI  $  IVF/ ICSI*  $$$$$  Artificial Insemination  ✔  ✔  Directed sperm delivery   (into fallopian tube where conception occurs)  ✔  No ovulation stimulation  optional  optional  No embryo transfer   ✔  ✔  Minimal training  ✔  ✔  14  For couples with male infertility, treatment with IVF/ ICSI is advised given the low success rates for IUI  *CDC (2016), >90% of couples with male factor infertility use Intracytoplasmic Sperm Injection (ICSI). 
 

 FemaSeed Localized Directional Insemination in Development  There’s been limited advancements and continuous demand for less costly options  First and only approach delivering sperm directly where conception occurs in the fallopian tube  15  Undirected sperm delivery to cavity (IUI) is first-line treatment despite low success rates 
 

 Summary:  Study Design: prospective, multi-center, unblinded, single arm  Study Population: male factor infertility  Sample Size: up to 214 subjects contributing 214 FemaSeed cycles   Primary Effectiveness Endpoint: Pregnancy Rate      Trial Designed to Expedite Clinical Program Advancement  FemaSeed de Novo Clinical Trial for Market Approval  SITE RECRUITMENT UNDERWAY  Pivotal Trial(IDE Approved October 2022)  16  To Evaluate Safety and Effectiveness 
 

 The Unmet Need in Infertility  17  For more than 20 years, current approaches to infertility treatment have been limited during the initial stage of therapeutic care, but with the advancement of FemaSeed, we believe a next generation intrauterine procedure may have the opportunity to truly change this traditional paradigm.  - Michael Glassner, MD  Founding Partner and Medical Director of Main Line Fertility & Reproductive Medicine 
 

 Companion Diagnostics: Test Prior to Infertility Treatments, including FemaSeed   Diagnostic performed prior to any infertility procedures  Can be combined with uterine cavity evaluation (standard of care)  On-line training and support available for new customers  Physician locator available on patient website  Reimbursed using existing codes  First In-office, Ultrasound Approach for Fallopian Tube Evaluation  Commercially Available: U.S., Japan, and other  FemVue creates saline-air contrast that travels through the fallopian tube(s) when open  18  First Intrauterine Catheter for Selective Tubal Evaluation 
 

 FemVue: Compelling Patient Testimonials  19  Being aware that there are many reasons why women have issues conceiving, FemVue is one easy procedure that can assist in finding out why it may have been difficult. As such, I highly recommend any woman who has tried for months or years to conceive to get the FemVue procedure. It is a procedure that will get you immediate results for you and your doctor to discuss the next steps of making your dreams come true.  After a month of completing successful medical procedures including FemVue, my husband and I conceived our first child.  - FemVue Patient Testimonial  - FemVue Patient Testimonial 
 

 Fertility Enabling Market Opportunity (U.S.)  Near-Term Target Market $800M Total  Market Expansion Opportunity $2B Total  Includes women choosing IUI and required tubal diagnosis  Intrauterine Insemination (IUI)  Diagnosis / Drugs  Discussion Only  IVF  (~200k cycles/ year)*  >10M Infertile Women  Most Expensive  Least Expensive  20  *Centers for Disease Control and Prevention. 2019 Assisted Reproductive Technology Fertility Clinic and National Summary Report. US Dept of Health and Human Services; 2021. 
 

 FemBloc®  Permanent Birth Control  First and only non-surgical, in-office, permanent birth control option in development with the potential to be the safest and most natural approach at half the cost of the long-standing surgical alternative  21  Contraception Focused Portfolio  Companion Diagnostics FemChec® and FemCath®  Includes first in-office ultrasound diagnosis of fallopian tubes for confirmation of procedure success 
 

 Since surgical tubal ligation has been performed since the 1880’s and remains the most common option for women who want permanent birth control.   Permanent Birth Control Alternatives: Unmet Need (U.S. only)  >13M women no longer intend to have children  >12M use non-permanent birth control, long-term  800,000 women choose surgical tubal ligation as a form of permanent birth control every year*  More than 100 years of stagnant innovation for permanent birth control  22  *Frattarelli 2007 
 

 *6% failure rate for laparoscopic sterilization (tubal ligation) and 5% failure rate for hysteroscopic sterilization (Essure), reported in published study as higher than expected (Fertility and Sterility, 2022)     Essure® is a registered trademark of Bayer Healthcare (Conceptus) and, as of December 2018, no longer a marketed solution.  FemBloc: Expected Competitive Advantages Over Existing or Previous Birth Control Options  On-Market Solutions  Off-Market  FemBloc  Surgical Tubal Ligation*  IUD  (Reversible)  Essure®*  Permanent  ✔  ✔  ✔  Office Procedure  ✔  ✔  Some  No Special Capital Equipment   ✔  ✔  No Anesthesia  ✔  ✔  No Permanent Implant (coil/ clip)  ✔  No Surgery (risks/ cost)  ✔  ✔  No Hormones  ✔  ✔  ✔  One-Time Treatment Cost  ✔  ✔  Multiple IUDs  ✔  Worldwide Applicability  ✔  Varies  ✔  23 
 

 Companion ultrasound procedure exclusive to FemBloc - confirms procedure success  Occlusion Confirmation  No Permanent Implant – Scar Tissue Closes Tubal Lumen  FemBloc Treatment  FemBloc Permanent Birth Control in Development  The first and only non-surgical, in-office approach  Balloon at tubal opening without cannulation  Biopolymer is designed to be expelled within 3 months  3 Months  Blockage  Biopolymer solidifies  Biopolymer degrades  Saline-air contrast confirms blockage  24 
 

 Summary:  n=183 subjects being followed for 5 years   Patients found procedures highly tolerable   Physicians found procedure to be extremely simple or very simple  99% physicians assessed easier than tubal ligation surgery  Summary:  n=93 subjects received planned hysterectomy   Subset with histopathology demonstrating biopolymer tissue reactions  No serious safety events reported  Summary:  n=45 subjects being followed for 5 years   Subjects received two confirmation tests (ultrasound and radiology)   Continued safety established; no serious AEs  Continued patient tolerability and physician ease of use established  Goals:  IDE approval of study design(prospective, multi-center, unblinded, single-arm study)  Investigational plan utilizes previous FDA approved third-party study designs:  Primary Endpoint: pregnancy rate at 1-year post confirmation test  Safety Follow-Up: 2-5 years post-market  Establish Safety & Effectivenessof FemBloc  Selection of ConfirmationTest for Pivotal  No Serious AEs Reported  Evaluated Delivery &Biopolymer Effectiveness  FemBloc Clinical Studies for Pre-Market Approval (PMA)  SITE RECRUITMENT UNDERWAY  Early Clinical  Stage I: Safety  Stage II: Validation  Stage III: Pivotal  (pending)  25  ✔  ✔   IDE Approval Expected Q2 2023  ✔ 
 

 215  28  57  12  2  2  3  18  13  FemBloc Treatment  (>90 days)  FemBloc: Majority AEs Were Mild and Occurred at Time of Procedure (N = 228 subjects from Stage I & II)  Patients are being followed for 5 years, with first subjects completed 5-year follow-up  91% AEs related to device/ procedure occurred within 7 days of procedure  75% AEs mild  No SAEs  26  Investigators rated extremely or very satisfied for 96% of FemBloc procedures 
 

 Bleeding/Spotting (59%)  Pain/Cramps (55%)  Other  40%  13.1%  3.5%  2.6%  34.5%  13.5%  7%  3.9%  1.3%  *Visual Analog Scale (VAS) from 0-10 was used, where 10 was the highest measure of pain/discomfort.  FemBloc: Most Common Reported AEs (>1%) Were Related to Bleeding/Spotting or Pelvic Pain/Cramping   Mean pain/ discomfort score* out of 10 as reported by patient in-office with no anesthesia:   4.6 for FemBloc treatment and 3.4 for confirmation  27 
 

 The Unmet Need for Women: Options for Family Planning  28  Although tubal ligation has been performed for over a century, women will benefit from an in-office approach that avoids the risks and discomforts associated with incisions, general anesthesia and surgery. FemBloc may expand much needed options for women seeking permanent contraception.  - Paul Blumenthal, MD, MPH  Professor Emeritus and Director of the Stanford Program for International Reproductive Education and Services (SPIRES) at Stanford University’s School of Medicine 
 

 Permanent Birth Control Market Opportunity (U.S.)  Near-Term Target Market $2B Annual  Market Expansion Opportunity $20B Total  Includes women (and partners) choosing permanent birth control annually (~1.3M)1,2  Includes women using non-permanent options but are candidates (>12M)3  Hormones  Condoms  Tubal Ligation Surgery  >13M Reproductive Aged Women NO Longer Intend Children  Most Invasive/ Most Reliable  Least Invasive / Least Reliable  29  Frattarelli 2007  Eisenberg ML 2009  Daniels K. NCHS Data Brief, no 388. 2020 
 

 FemBloc: Improved Health Economics  Permanent One-Time Cost Breakdown  Pre-Op   $6,000*  Facility  Anesthesia  Post-Op  Cost of FemBloc System  Anesthesia  Physician / Practice  Est < ½ cost of Tubal Ligation  Physician  In-office procedure expands practice services  Can perform multiple procedures in same room  Quick to perform; ease of room turnover  Patient resumes normal activities  FemBloc Efficiencies  *Planned Parenthood 2019, https://www.plannedparenthood.org/learn/birth-control;Doximity 2019; U.S. Bureau of Labor Statistics, 2019.   30 
 

 In-office procedure  FemBloc Treatment  Category covered (ACA)  Cat III code approved  2  FemBloc: Clear Reimbursement Path  3 reimbursable visits  1+ Days  3 Months  In-office/ TeleVisit(required for permanent birth control)  Counseling/Eligibility  Existing CPT codes  1  In-office test   (ultrasound)  Cat III code approved  FemBloc Confirmation  3  31 
 

 FemBloc Has Potential to be a Game-Changer for Women  32  Large Market  Unmet Need  Designed with Patient and Physician in Mind  Growing demand with overturn of Roe v. Wade  Only surgical tubal ligation available (costly, difficult to access, lower effectiveness rate)  In-office, convenient and quick  Safe, non-implant approach   No cost through ACA  In-office technique leverages existing skill set  Easy to incorporate into practice  Clear path to reimbursement   For the Patient  For the Physician 
 

 Femasys is Prepared for Execution  33  Clear Clinical Path to FDA Approval  Clear Reimbursement Pathway  Commercial Expertise  Full manufacture facility with ability to scale and transfer  MFG Ready  Sales Ready  Building commercial infrastructure before salesforce with FDA cleared products for GYNs 
 

 34  FemCerv®  Diagnostic for Cervical Cancer   First endocervical biopsy designed for comprehensive tissue sampling with minimal contamination  First endometrial biopsy in development with the potential to capture comprehensive tissue sample   FemEMB™  Diagnostic for Uterine Cancer  Coming Soon 
 

 Cervical Cancer: Unmet Need (U.S. only)   Inadequate cervical cancer screening remains a significant problem with persistent health inequities across the entire spectrum of cervical cancer care. 1  35  1 (https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2021/04/updated-cervical-cancer-screening-guidelines)  2 Obstet Gynecol. 2017 December ; 130(6): 1218–1225. doi:10.1097/AOG.0000000000002330.   >3M women undergo colposcopic evaluation each year for abnormal screening cytology.2  Endocervical curettage (ECC) has been increasingly incorporated in the colposcopy-biopsy examination. 
 

 FemCerv: Competitive Advantages Over Existing Options  FemCerv  Kevorkian Curette  Endocervical Brush  Relatively pain-free   ✔  Protects sample against cross contamination  ✔  Collects a comprehensive, 360o sample   ✔  High sample adequacy  ✔  ✔  ✔  Ease of use  ✔  ✔  ✔  36  The incidence of stage IV cervical cancer in the U.S. is increasing.*  *Francoeur et. al, International Journal of Gynecologic Cancer (2022).  
 

 Expanded Collection   Chamber  FemCerv: Post-Market Clinical Data Supports Product Advantages  1  2  Collected sample  37  Study Conclusion  Endocervical curettage (tissue sampling) for the routine investigation of patients with abnormal cervical cytology was successfully conducted with the FemCerv Endocervical Sampler.  Device typically provided adequate samples for histological evaluation.   Device’s rounded tapered tip was easy to insert in most patients.   Procedure was well tolerated by almost all patients, who experienced mild or no discomfort.  Endocervical Curettage with the FemCerv Endocervical Sampler*  *Marcus, et al. Endocervical Curettage with the FemCerv Endocervical Sampler. JMIG. 2013 https://doi.org/10.1016/j.jmig.2013.08.362 
 

 U.S. Commercial Strategy: Planning for Commercial Readiness   38  Initial Focus on Infertility Specialists   + Added Focus on Gynecologists  Product Candidates  FemaSeed  FemBloc  FemVue  Available  FemCath  Available  FemCerv  Available  FDA Cleared   Diagnostic Products  Commercial-ready capacity for production; in-house manufacturing already in-place  ~1,700  ~40,000 
 

 Upcoming Anticipated Milestones / Events  Near term expected valuation inflection points creating accretive value for investors  39  2024  Q2  Complete FemaSeed enrollment de novo pivotal trial   Q2  Q3  2023  FDA IDE approval for FemBloc pivotal    trial to support   PMA approval  Begin FemBloc pivotal trial enrollment   Q4  Q1  File FemEMB    submission    with FDA   U.S. Launch FemaSeed    
 

 Investment Highlights  Biomedical Company Disrupting the Approaches to Women’s Health with Proprietary Diagnostic and Device Solutions in Development  Addressing Multi-Billion Dollar Global Market Opportunities in Infertility and Permanent Birth Control With Differentiated and Improved Approaches  Clear Reimbursement Path with Limited Competition Yields Improved Patient Care and Health Economics  40  Intellectual Property Portfolio with >150 Patents Globally  Cash Runway into Q2 2024  Woman-Founded and Led, Experienced Leadership Team with Concentrated Development Expertise  Commercial-Readiness Based on In-House CMC and Device Infrastructure; Audited Systems Allow for Risk Mitigation  Supply Chain Control; No Reliance on Third-Party Manufacturing  Mission  Differentiator  Foundation 
 

 Disrupting Convention in Women’s Health Through Continuous Innovation  May 2023  Corporate Presentation  Investors:   [email protected]  Contact:   Media:  [email protected]   41  03333 R04