Exhibit 99.1

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Janus Henderson Group plc Reports Third Quarter 2021 Diluted EPS of US$1.14,

or US$1.16 on an Adjusted Basis

●

Solid investment performance, with 72%, 64%, 67% and 86% of assets under management (‘AUM’) outperforming relevant benchmarks on a one-, three-, five- and 10-year basis, respectively, as at 30 September 2021

●

Third quarter 2021 operating income was US$248.3 million; third quarter 2021 adjusted operating income of US$253.0 million increased 56% compared to the same period a year ago

●

AUM of US$419.3 billion decreased 2% compared to the prior quarter, primarily due to net outflows of US$(5.2) billion which were concentrated in Quantitative Equities

●

Completed US$75.0 million of share buybacks during the third quarter

●

Board declared quarterly dividend of US$0.38 per share

LONDON — Janus Henderson Group plc (NYSE/ASX: JHG; ‘JHG’, ‘the Group’) published its third quarter 2021 results for the period ended 30 September 2021.

Third quarter 2021 operating income was US$248.3 million compared to US$225.0 million in the second quarter 2021 and US$156.5 million in the third quarter 2020. Adjusted operating income, adjusted for one-time, acquisition and transaction related costs, was US$253.0 million in the third quarter 2021 compared to US$269.3 million in the second quarter 2021 and US$162.1 million in the third quarter 2020.

Third quarter 2021 diluted earnings per share of US$1.14 increased 44% compared to US$0.79 in the second quarter 2021 and increased 75% compared to US$0.65 in the third quarter 2020. Adjusted diluted earnings per share of US$1.16 in the third quarter 2021 was flat versus US$1.16 in the second quarter 2021 and increased 66% compared to US$0.70 in the third quarter 2020.

Dick Weil, Chief Executive Officer of Janus Henderson Group plc, stated:

“Third quarter financial results were strong with adjusted operating income of US$253.0 million and adjusted diluted EPS of US$1.16 up 56% and 66%, respectively, from one year ago, demonstrating the operating leverage in our business.

“We have made significant progress delivering our strategy of Simple Excellence, which is resulting in momentum building across the business. We have a strong foundation, and the progress we have made allows us to take advantage of trends that our clients are asking us to support them on. We expect this to result in the delivery of growth through organic and inorganic opportunities that accentuate our distribution excellence, our investment expertise and our differentiated operating platform.”

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SUMMARY OF FINANCIAL RESULTS (unaudited) (in US$ millions, except per share data or as noted)

The Group presents its financial results in US$ and in accordance with accounting principles generally accepted in the United States of America (‘US GAAP’ or ‘GAAP’). However, JHG management evaluates the profitability of the Group and its ongoing operations using additional non-GAAP financial measures. Management uses these performance measures to evaluate the business, and adjusted values are consistent with internal management reporting. See ‘Reconciliation of non-GAAP financial information’ below for additional information.


	Three months ended
	30 Sep		30 Jun		30 Sep
	2021		2021		2020
GAAP basis:
Revenue	687.4		738.4		568.5
Operating expenses	439.1		513.4		412.0
Operating income	248.3		225.0		156.5
Operating margin	36.1	%	30.5	%	27.5	%
Net income attributable to JHG	196.8		137.3		118.9
Diluted earnings per share	1.14		0.79		0.65

Adjusted basis:
Revenue	545.3		603.6		449.7
Operating expenses	292.3		334.3		287.6
Operating income	253.0		269.3		162.1
Operating margin	46.4	%	44.6	%	36.0	%
Net income attributable to JHG	199.5		200.5		129.6
Diluted earnings per share	1.16		1.16		0.70

DIVIDEND AND SHARE BUYBACK

On 27 October 2021, the Board declared a third quarter dividend in respect of the three months ended 30 September 2021 of US$0.38 per share. Shareholders on the register on the record date of 8 November 2021 will be paid the dividend on 24 November 2021. Janus Henderson does not offer a dividend reinvestment plan.

As part of the US$200 million on-market buyback programme approved by the Board in July 2021, JHG purchased approximately 1.8 million of its ordinary shares on the NYSE and its CHESS Depositary Interests (CDIs) on the ASX in the third quarter, for a total outlay of US$75.0 million.

Net tangible assets per share


US$	30 Sep 2021	31 Dec 2020
Net tangible assets / (liabilities) per ordinary share	3.93	3.68

Net tangible assets are defined by the ASX as being total assets less intangible assets less total liabilities ranking ahead of, or equally with, claims of ordinary shares.

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AUM AND FLOWS (in US$ billions)

FX reflects movement in AUM resulting from changes in foreign currency rates as non-US$ denominated AUM is translated into US$. Redemptions include impact of client switches.

Total Group comparative AUM and flows


	Three months ended
	30 Sep	30 Jun	30 Sep
	2021	2021	2020
Opening AUM	427.6	405.1	336.7
Sales	16.0	18.4	15.8
Redemptions	(21.2)	(20.9)	(18.7)
Net sales / (redemptions)	(5.2)	(2.5)	(2.9)
Market / FX	(3.1)	25.0	24.5
Closing AUM	419.3	427.6	358.3

Quarterly AUM and flows by capability


		Fixed		Quantitative
	Equities	Income	Multi-Asset	Equities	Alternatives	Total
AUM 30 Sep 2020	188.9	75.1	43.6	40.7	10.0	358.3
Sales	10.3	8.7	3.1	0.3	0.8	23.2
Redemptions	(10.4)	(7.5)	(1.9)	(3.7)	(0.8)	(24.3)
Net sales / (redemptions)	(0.1)	1.2	1.2	(3.4)	—	(1.1)
Market / FX	30.6	5.2	3.2	4.7	0.7	44.4
AUM 31 Dec 2020	219.4	81.5	48.0	42.0	10.7	401.6
Sales	10.5	5.9	3.0	0.2	1.1	20.7
Redemptions	(12.0)	(5.5)	(2.2)	(2.3)	(2.0)	(24.0)
Net sales / (redemptions)	(1.5)	0.4	0.8	(2.1)	(0.9)	(3.3)
Market / FX	7.0	(2.4)	0.7	1.4	0.1	6.8
AUM 31 Mar 2021	224.9	79.5	49.5	41.3	9.9	405.1
Sales	8.6	5.9	2.4	0.2	1.3	18.4
Redemptions	(10.5)	(6.0)	(1.9)	(1.5)	(1.0)	(20.9)
Net sales / (redemptions)	(1.9)	(0.1)	0.5	(1.3)	0.3	(2.5)
Market / FX	17.1	1.1	3.2	3.4	0.2	25.0
AUM 30 Jun 2021	240.1	80.5	53.2	43.4	10.4	427.6
Sales	7.5	4.7	2.6	0.1	1.1	16.0
Redemptions	(10.1)	(4.0)	(1.8)	(4.5)	(0.8)	(21.2)
Net sales / (redemptions)	(2.6)	0.7	0.8	(4.4)	0.3	(5.2)
Market / FX	(1.3)	(1.7)	(0.1)	0.1	(0.1)	(3.1)
AUM 30 Sep 2021	236.2	79.5	53.9	39.1	10.6	419.3

Average AUM


	Three months ended
	30 Sep	30 Jun	30 Sep
	2021	2021	2020
Equities	243.5	235.3	188.5
Fixed Income	80.9	80.7	74.8
Multi-Asset	54.9	51.8	42.7
Quantitative Equities	41.9	42.9	40.0
Alternatives	10.7	10.1	10.0
Total	431.9	420.8	356.0

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INVESTMENT PERFORMANCE

% of AUM outperforming benchmark (at 30 September 2021)


Capability	1-year		3-year		5-year		10-year
Equities	64	%	56	%	60	%	84	%
Fixed Income	98	%	96	%	96	%	99	%
Multi-Asset	99	%	97	%	97	%	97	%
Quantitative Equities	41	%	2	%	2	%	32	%
Alternatives	94	%	97	%	100	%	100	%
Total	72	%	64	%	67	%	86	%

Outperformance is measured based on composite performance gross of fees vs primary benchmark, except where a strategy has no benchmark index or corresponding composite in which case the most relevant metric is used: (1) composite gross of fees vs zero for absolute return strategies, (2) fund net of fees vs primary index or (3) fund net of fees vs Morningstar peer group average or median. Non-discretionary and separately managed account assets are included with a corresponding composite where applicable.

Cash management vehicles, ETFs, Managed CDOs, Private Equity funds and custom non-discretionary accounts with no corresponding composite are excluded from the analysis. Excluded assets represent 5% of AUM as at 30 September 2021. Capabilities defined by Janus Henderson.

% of mutual fund AUM in top 2 Morningstar quartiles (at 30 September 2021)


Capability	1-year		3-year		5-year		10-year
Equities	47	%	47	%	49	%	68	%
Fixed Income	84	%	77	%	73	%	69	%
Multi-Asset	20	%	92	%	92	%	94	%
Quantitative Equities	11	%	11	%	11	%	0	%
Alternatives	27	%	70	%	74	%	98	%
Total	47	%	59	%	60	%	73	%

Includes Janus Investment Fund, Janus Aspen Series and Clayton Street Trust (US Trusts), Janus Henderson Capital Funds (Dublin based), Dublin and UK OEIC and Investment Trusts, Luxembourg SICAVs and Australian Managed Investment Schemes. The top two Morningstar quartiles represent funds in the top half of their category based on total return. For the 1-, 3-, 5- and 10-year periods ending 30 September 2021, 46%, 54%, 50% and 61% of the 195, 185, 180 and 150 total mutual funds, respectively, were in the top 2 Morningstar quartiles.

Analysis based on ‘primary’ share class (Class I Shares, Institutional Shares or share class with longest history for US Trusts; Class A Shares or share class with longest history for Dublin based; primary share class as defined by Morningstar for other funds). Performance may vary by share class. Rankings may be based, in part, on the performance of a predecessor fund or share class and are calculated by Morningstar using a methodology that differs from that used by Janus Henderson. Methodology differences may have a material effect on the return and therefore the ranking. When an expense waiver is in effect, it may have a material effect on the total return, and therefore the ranking for the period.

FOURTH QUARTER AND FULL-YEAR 2021 RESULTS

Janus Henderson intends to publish its fourth quarter and full-year 2021 results on 3 February 2022.

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THIRD QUARTER 2021 RESULTS BRIEFING INFORMATION

Chief Executive Officer Dick Weil and Chief Financial Officer Roger Thompson will present these results on 28 October 2021 on a conference call and webcast to be held at 8am EDT, 1pm BST, 11pm AEDT.

Those wishing to participate should call:


United Kingdom	0800 279 9489 (toll free)
United States	866 270 1533 (toll free)
Australia	1 800 121 301 (toll free)
All other countries	+1 412 317 0797 (this is not toll free)
Conference ID	10160342

Access to the webcast and accompanying slides will be available via the investor relations section of Janus Henderson’s website (ir.janushenderson.com).

About Janus Henderson

Janus Henderson Group is a leading global active asset manager dedicated to helping investors achieve long-term financial goals through a broad range of investment solutions, including equities, fixed income, quantitative equities, multi-asset and alternative asset class strategies.

At 30 September 2021, Janus Henderson had approximately US$419 billion in assets under management, more than 2,000 employees, and offices in 25 cities worldwide. Headquartered in London, the company is listed on the New York Stock Exchange (NYSE) and the Australian Securities Exchange (ASX).


Investor enquiries:		Media enquiries:
Jim Kurtz		Stephen Sobey
Co-Head Investor Relations (US) +1 303 336 4529		Head of Media Relations +44 (0)20 7818 2523
[email protected]		[email protected]

Melanie Horton		Sarah Johnson
Co-Head Investor Relations (Non-US)		Director, Media Relations & Corp Comms
+44 (0)20 7818 2905		+1 720 364 0708
[email protected]		[email protected]

Or		United Kingdom: Edelman Smithfield
		Latika Shah
Investor Relations		+44 (0)7950 671 948
[email protected]		[email protected]

		Andrew Wilde
		+44 (0)7786 022 022
		[email protected]

		Asia Pacific: Honner
		Craig Morris
		+61 2 8248 3757
		[email protected]

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FINANCIAL DISCLOSURES

Condensed consolidated statements of comprehensive income (unaudited)


	Three months ended
	30 Sep	30 Jun	30 Sep
(in US$ millions, except per share data or as noted)	2021	2021	2020
Revenue:
Management fees	564.5	544.1	457.7
Performance fees	0.6	77.4	7.0
Shareowner servicing fees	67.6	64.0	53.7
Other revenue	54.7	52.9	50.1
Total revenue	687.4	738.4	568.5

Operating expenses:
Employee compensation and benefits	166.2	192.4	154.9
Long-term incentive plans	35.0	49.8	42.7
Distribution expenses	142.1	134.8	118.8
Investment administration	13.0	13.1	13.1
Marketing	7.5	6.7	5.3
General, administrative and occupancy	65.5	65.7	65.6
Impairment of goodwill and intangible assets	—	40.8	—
Depreciation and amortisation	9.8	10.1	11.6
Total operating expenses	439.1	513.4	412.0

Operating income	248.3	225.0	156.5

Interest expense	(3.2)	(3.2)	(3.2)
Investment gains, net	4.7	1.8	25.5
Other non-operating income (expense), net	3.6	(2.7)	(0.9)
Income before taxes	253.4	220.9	177.9
Income tax provision	(53.3)	(79.7)	(40.8)
Net income	200.1	141.2	137.1
Net income attributable to noncontrolling interests	(3.3)	(3.9)	(18.2)
Net income attributable to JHG	196.8	137.3	118.9
Less: allocation of earnings to participating stock-based awards	(5.4)	(3.9)	(3.5)
Net income attributable to JHG common shareholders	191.4	133.4	115.4

Basic weighted-average shares outstanding (in millions)	167.1	167.6	178.4
Diluted weighted-average shares outstanding (in millions)	167.8	168.1	178.8

Diluted earnings per share (in US$)	1.14	0.79	0.65

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Reconciliation of non-GAAP financial information

In addition to financial results reported in accordance with GAAP, we compute certain financial measures using non-GAAP components, as defined by the SEC. These measures are not in accordance with, or a substitute for, GAAP, and our financial measures may be different from non-GAAP financial measures used by other companies. We have provided a reconciliation of our non-GAAP components to the most directly comparable GAAP components. The following are reconciliations of US GAAP revenue, operating expenses, operating income, net income attributable to JHG and diluted earnings per share to adjusted revenue, adjusted operating expenses, adjusted operating income, adjusted net income attributable to JHG and adjusted diluted earnings per share.


	Three months ended
	30 Sep		30 Jun		30 Sep
(in US$ millions, except per share data or as noted)	2021		2021		2020
Reconciliation of revenue to adjusted revenue
Revenue	687.4		738.4		568.5
Management fees¹	(53.0)		(49.6)		(47.9)
Shareowner servicing fees¹	(55.4)		(53.1)		(42.8)
Other revenue¹	(33.7)		(32.1)		(28.1)
Adjusted revenue	545.3		603.6		449.7

Reconciliation of operating expenses to adjusted operating expenses
Operating expenses	439.1		513.4		412.0
Employee compensation and benefits²	—		—		(0.3)
Long-term incentive plans²	0.1		0.1		0.1
Distribution expenses¹	(142.1)		(134.8)		(118.8)
General, administration and occupancy²	(2.9)		(1.7)		(3.5)
Impairment of goodwill and intangible assets³	—		(40.8)		—
Depreciation and amortisation³	(1.9)		(1.9)		(1.9)
Adjusted operating expenses	292.3		334.3		287.6

Adjusted operating income	253.0		269.3		162.1

Operating margin	36.1	%	30.5	%	27.5	%
Adjusted operating margin	46.4	%	44.6	%	36.0	%

Reconciliation of net income attributable to JHG to adjusted net income attributable to JHG
Net income attributable to JHG	196.8		137.3		118.9
Employee compensation and benefits²	—		—		0.3
Long-term incentive plans²	(0.1)		(0.1)		(0.1)
General, administration and occupancy²	2.9		1.7		3.5
Impairment of goodwill and intangible assets³	—		40.8		—
Depreciation and amortisation³	1.9		1.9		1.9
Other non-operating income (expense), net⁴	(1.6)		(1.7)		(0.5)
Income tax benefit (provision)⁵	(0.4)		20.6		5.6
Adjusted net income attributable to JHG	199.5		200.5		129.6
Less: allocation of earnings to participating stock-based awards	(5.5)		(5.7)		(3.8)
Adjusted net income attributable to JHG common shareholders	194.0		194.8		125.8

Weighted-average diluted common shares outstanding – diluted (two class) (in millions)	167.8		168.1		178.8
Diluted earnings per share (two class) (in US$)	1.14		0.79		0.65
Adjusted diluted earnings per share (two class) (in US$)	1.16		1.16		0.70

JHG contracts with third-party intermediaries to distribute and service certain of its investment products. Fees for distribution and servicing related activities are either provided for separately in an investment product’s prospectus or are part of the management fee. Under both arrangements, the fees are collected by JHG and passed through to third-party intermediaries who are responsible for performing the applicable services. The majority of distribution and servicing fees collected by JHG are passed through to third-party intermediaries. JHG management believes that the deduction of distribution and service fees from revenue in the computation of adjusted revenue reflects the pass-through nature of these revenues. In certain arrangements, JHG performs the distribution and servicing activities and retains the applicable fees. Revenues for distribution and servicing activities performed by JHG are not deducted from GAAP revenue.

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Adjustments primarily represent rent expense for subleased office space. In addition, the adjustment for the three months ended 30 September 2021 includes a one-time charge related to the employee benefits trust. JHG management believes these costs are not representative of the ongoing operations of the Group.

Investment management contracts have been identified as a separately identifiable intangible asset arising on the acquisition of subsidiaries and businesses. Such contracts are recognised at the net present value of the expected future cash flows arising from the contracts at the date of acquisition. For segregated mandate contracts, the intangible asset is amortised on a straight-line basis over the expected life of the contracts. Adjustments for the three months ended 30 June 2021 also include impairment charges of certain mutual fund investment management agreements. JHG management believes these non-cash and acquisition-related costs are not representative of the ongoing operations of the Group.

4	Adjustments primarily relate to contingent consideration adjustments associated with prior acquisitions. JHG management believes these costs are not representative of the ongoing operations of the Group.

The tax impact of the adjustments is calculated based on the applicable US or foreign statutory tax rate as it relates to each adjustment. Certain adjustments are either not taxable or not tax-deductible. Adjustments for the three months ended 30 June 2021 include a non-cash deferred tax expense of US$31.0 million due to the enactment of Finance Act 2021 during the second quarter 2021.

Condensed consolidated balance sheets (unaudited)


	30 Sep	31 Dec
(in US$ millions)	2021	2020
Assets:
Cash and cash equivalents	933.1	1,099.7
Investment securities	445.2	268.1
Property, equipment and software, net	63.7	77.9
Intangible assets and goodwill, net	3,991.7	4,070.2
Assets of consolidated variable interest entities	258.8	226.5
Other assets	1,010.7	948.4
Total assets	6,703.2	6,690.8

Liabilities, redeemable noncontrolling interests and equity:
Long-term debt	311.1	313.3
Deferred tax liabilities, net	644.7	627.4
Liabilities of consolidated variable interest entities	2.9	3.2
Other liabilities	937.2	927.3
Redeemable noncontrolling interests	145.1	85.8
Total equity	4,662.2	4,733.8
Total liabilities, redeemable noncontrolling interests and equity	6,703.2	6,690.8

Condensed consolidated statements of cash flows (unaudited)


	Three months ended
	30 Sep	30 Jun	30 Sep
(in US$ millions)	2021	2021	2020
Cash provided by (used for):
Operating activities	319.4	269.0	183.0
Investing activities	(222.9)	(66.3)	135.0
Financing activities	(112.9)	(62.0)	(291.2)
Effect of exchange rate changes	(16.3)	—	19.3
Net change during period	(32.7)	140.7	46.1

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STATUTORY DISCLOSURES

Associates and joint ventures

At 30 September 2021, the Group holds interests in the following associates and joint ventures managed through shareholder agreements with third party investors, accounted for under the equity method:

●

LongTail Alpha LLC ownership 20%

Basis of preparation

In the opinion of management of Janus Henderson Group plc, the condensed consolidated financial statements contain all normal recurring adjustments necessary to fairly present the financial position, results of operations and cash flows of JHG in accordance with US GAAP. Such financial statements have been prepared in accordance with the instructions to Form 10-Q pursuant to the rules and regulations of the SEC. Certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. The financial statements should be read in conjunction with the annual consolidated financial statements and notes presented in Janus Henderson Group’s Annual Report on Form 10-K for the year ended 31 December 2020, on file with the SEC (Commission file no. 001-38103). Events subsequent to the balance sheet date have been evaluated for inclusion in the financial statements through the issuance date and are included in the notes to the condensed consolidated financial statements.

Corporate governance principles and recommendations

In the opinion of the Directors, the financial records of the Group have been properly maintained, and the Condensed Consolidated Financial Statements comply with the appropriate accounting standards and give a true and fair view of the financial position and performance of the Group. This opinion has been formed on the basis of a sound system of risk management and internal control which is operating effectively.

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FORWARD-LOOKING STATEMENTS DISCLAIMER

Past performance is no guarantee of future results. Investing involves risk, including the possible loss of principal and fluctuation of value.

This document includes statements concerning potential future events involving Janus Henderson Group plc that could differ materially from the events that actually occur. The differences could be caused by a number of factors, including those factors identified in Janus Henderson Group’s Annual Report on Form 10-K for the fiscal year ended 31 December 2020 and in other filings or furnishings made by the Company with the Securities and Exchange Commission from time to time (Commission file no. 001-38103), including those that appear under headings such as ‘Risk Factors’ and ‘Management’s Discussion and Analysis of Financial Condition and Results of Operations’. Many of these factors are beyond the control of JHG and its management. Any forward-looking statements contained in this document are as at the date on which such statements were made. Janus Henderson Group undertakes no obligation to publicly update or revise any forward-looking statements after the date they are made, whether as a result of new information, future events or otherwise, except as required by law.

Annualised, pro forma, projected and estimated numbers are used for illustrative purposes only, are not forecasts and may not reflect actual results.

The information, statements and opinions contained in this document do not constitute a public offer under any applicable legislation or an offer to sell or solicitation of any offer to buy any securities or financial instruments or any advice or recommendation with respect to such securities or other financial instruments.

Not all products or services are available in all jurisdictions.

Mutual funds in the US are distributed by Janus Henderson Distributors.

Please consider the charges, risks, expenses and investment objectives carefully before investing. For a US fund prospectus or, if available, a summary prospectus containing this and other information, please contact your investment professional or call 800.668.0434. Read it carefully before you invest or send money.

Page | 10

Exhibit 99.2

Thursday 28 October 2021 THIRD QUARTER 2021 RESULTS Dick Weil Chief Executive Officer Roger Thompson Chief Financial Officer

STRATEGY UPDATE Dick Weil Chief Executive Officer

3 OUR STRATEGY: SIMPLE EXCELLENCE Strengthening our core foundation while maximising growth potential Delivering on our strategy of Simple Excellence Produce dependable investment outcomes Excel in distribution and client experience Develop new growth initiatives Focus and increase operational efficiency Proactive risk and control environment Positive flows and AUM growth Revenue stability and profitability A return to consistent net inflows driven by organic growth across regions, client types and investment capabilities A growing and diversified AUM and client base, able to weather shifting market environments Revenue stability resulting from a focus on profitable growth, recognising changing investor trends globally A balanced approach to managing costs, allowing for investment, expanded profitability and increased cash flow generation Simple Excellence lays the foundation for sustained organic and inorganic growth to create value for all our stakeholders: our clients, shareholders and employees

4 33.5% 36.0% 43.8% 39.0% 44.6% 46.4% 20.6% 27.5% 34.5% 29.9% 30.5% 36.1% Q2 2020 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Adjusted operating margin Operating margin MOMENTUM IN RESULTS ✓ Solid investment performance forms the foundation for growing distribution momentum across our global footprint ✓ Strong distribution momentum with improving net flows in our core business and new product extensions and launches Growing distribution momentum ✓ Resilient revenue profile supported by strong growth in higher-fee products and global marketplaces ✓ Operating leverage driven by revenue growth supported by ongoing focus on expenses ✓ Disciplined use of capital, with ongoing returns to shareholders and flexibility to pursue growth ✓ The accretive buyback programme has resulted in a 15% reduction in shares outstanding since 2018 We have built a globally diversified, highly profitable and cash-generative business Resilient, high-margin financial profile Strong capital position and return (6%) (6%) (7%) (6%) (7%) (5%) (2%) (1%) (0%) Q3 2019 Q4 2019 Q1 2020 Q2 2020 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 1 Last twelve months (LTM) net organic growth rates calculated as net flows as a percentage of beginning period AUM. 2 See adjusted financial measures reconciliation on slide 31 for additional information. 45.7 45.8 45.9 46.8 47.1 47.0 Q2 2020 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 LTM1 net organic growth excluding Quantitative Equity Net management fee rate (bps) 2018 to 2021 YTD capital return (US$m) Operating margins2 275 272 263 192 100 200 131 305 375 472 394 497 56% 102% 61% 81% 2018 2019 2020 2021 YTD Dividends Share repurchases Capital return as % of cash flow from operations

5 WELL-POSITIONED FOR GROWTH Building on Simple Excellence as a foundation for new growth initiatives Trends across our strategic focus areas We are well-positioned to execute on our growth strategy ▪ Global adoption of ESG and sustainable investing ▪ Accelerating growth, expanding distribution channels for active ETFs ▪ Increasing importance of high-growth emerging markets (Asia, LatAm) ▪ Structural tailwinds driving growth in high-quality income and alternatives ▪ Customisation redefining portfolio solutions delivery ▪ The emergence of digital assets and blockchain technology  Strong financial position and cash generation to invest in growth  Client-centric culture rooted in collaboration and Simple Excellence  Independent, globally-diversified, active investment manager  Track record of excellence across equity, fixed income and multi-asset capabilities

BUSINESS AND FINANCIAL UPDATE Roger Thompson Chief Financial Officer

7 1 Represents percentage of AUM outperforming the relevant benchmark. Full performance disclosures detailed in the appendix on slide 25. 2 See adjusted financial measures reconciliation on slides 31 and 32 for additional information. Key metrics – Q3 2021 vs Q2 2021 Q3 2021 RESULTS ▪ Long-term investment performance remains solid ▪ AUM declined 2% to US$419.3bn, due primarily to net outflows of US$(5.2)bn which were concentrated in Quantitative Equities ▪ Adjusted diluted EPS of US$1.16 is flat to prior quarter and an increase of 66% versus Q3 2020 ▪ Declared US$0.38 per share dividend and completed US$75m of share buybacks Q3 2021 Q2 2021 3-year investment outperformance¹ 64% 66% Net flows US$(5.2)bn US$(2.5)bn Total AUM US$419.3bn US$427.6bn US GAAP diluted EPS US$1.14 US$0.79 Adjusted diluted EPS² US$1.16 US$1.16 Dividend per share US$0.38 US$0.38

8 INVESTMENT PERFORMANCE Note: Full performance disclosures detailed in the appendix on slides 25 and 26. The top two Morningstar quartiles represent funds in the top half of their category based on total return. The top quartile represents those in the top 25%. Refer to slide 26 for the percent of funds in the top 2 quartiles for all periods and description and quantity of funds included in the analysis; refer to slides 27 to 29 for distribution across first and second quartiles. Past performance is no guarantee of future results. Capability 1-year 3-year 5-year 10-year Equities Fixed Income Multi-Asset Quantitative Equities Alternatives Total Capability 1-year 3-year 5-year 10-year Equities Fixed Income Multi-Asset Quantitative Equities Alternatives Total % of mutual fund AUM in top 2 Morningstar quartiles As at 30 Sep 21 % of AUM outperforming benchmark As at 30 Sep 21 41% 2% 2% 67% 64% 72% 100% 97% 94% 97% 97% 99% 96% 96% 98% 60% 56% 64% 11% 11% 11% 60% 59% 47% 74% 70% 27% 92% 92% 20% 73% 77% 84% 49% 47% 47% ▪ 47% and 45% of mutual fund AUM is in the top Morningstar quartile on a 3- and 5-year basis, respectively, as at 30 September 2021 Long-term investment performance remains solid 32% 86% 100% 97% 99% 84% 0% 73% 98% 94% 69% 68%

9 15.3 18.7 21.4 17.9 15.8 23.2 20.7 18.4 16.0 (18.8) (25.4) (33.6) (26.1) (18.7) (24.3) (24.0) (20.9) (21.2) (3.5) (6.7) (12.2) (8.2) (2.9) (1.1) (3.3) (2.5) (5.2) Q3 2019 Q4 2019 Q1 2020 Q2 2020 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q3 2019 to Q3 2021 total flows (US$bn) Redemptions Sales Net sales / (redemptions) 17% 21% 23% 25% 19% 26% 21% 18% 15% Annualised gross sales¹ Annualised gross redemptions¹ 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM. TOTAL FLOWS Net flows declined quarter over quarter with a decrease in gross sales (21%) (29%) (36%) (36%) (22%) (27%) (24%) (21%) (20%)

10 3.7 8.8 3.3 4.2 2.5 (5.6) (10.0) (6.8) (6.0) (8.3) (1.9) (1.2) (3.5) (1.8) (5.8) Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 11.5 13.5 16.5 13.5 12.9 (11.6) (12.5) (15.4) (13.5) (11.7) (0.1) 1.0 1.1 - 1.2 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 0.6 0.9 0.9 0.7 0.6 (1.5) (1.8) (1.8) (1.4) (1.2) (0.9) (0.9) (0.9) (0.7) (0.6) Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Intermediary (US$bn) 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM. QUARTERLY FLOWS BY CLIENT TYPE Redemptions Sales Net sales / (redemptions) Institutional (US$bn) 13% 30% 11% 13% 7% 29% 32% 35% 28% 25% 4% 5% 4% 4% 3% (20%) (34%) (22%) (19%) (25%) (29%) (29%) (32%) (28%) (23%) (9%) (10%) (9%) (7%) (6%) Annualised gross redemptions¹ Annualised gross sales¹ Self-Directed (US$bn) Net flows reflect improvement in Intermediary and a decline in Institutional

11 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM. Q3 2021 FLOWS BY CAPABILITY Net flows reflect strength in Fixed Income, Multi-Asset and Alternatives 7.5 4.7 2.6 0.1 1.1 (10.1) (4.0) (1.8) (4.5) (0.8) (2.6) 0.7 0.8 (4.4) 0.3 Equities Fixed Income Multi-Asset Quantitative Equities Alternatives Annualised gross sales¹ Redemptions Sales Net sales / (redemptions) 12% 23% 20% 1% 42% Annualised gross redemptions¹ (17%) (19%) (14%) (41%) (30%) Q3 2021 flows by capability (US$bn)

12 US GAAP Adjustments Adjusted Revenue Management fees 564.5 (53.0) 511.5 Performance fees 0.6 – 0.6 Shareowner servicing fees 67.6 (55.4) 12.2 Other revenue 54.7 (33.7) 21.0 Total revenue 687.4 (142.1) 545.3 Operating expenses Employee compensation and benefits 166.2 – 166.2 Long-term incentive plans 35.0 0.1 35.1 Distribution expenses 142.1 (142.1) – Investment administration 13.0 – 13.0 Marketing 7.5 – 7.5 General, administrative and occupancy 65.5 (2.9) 62.6 Depreciation and amortisation 9.8 (1.9) 7.9 Total operating expenses 439.1 (146.8) 292.3 Operating income 248.3 4.7 253.0 (US$m) 3 months ended 30 Sep 21 STATEMENT OF INCOME US GAAP and adjusted Note: See adjusted financial measures reconciliation on slides 31 and 32 for additional information.

13 (US$, except margin data) Q3 2021 Q2 2021 Change Q3 2021 vs Q2 2021 Q3 2020 Change Q3 2021 vs Q3 2020 Average AUM 431.9bn 420.8bn 3% 356.0bn 21% Total revenue 687.4m 738.4m (7%) 568.5m 21% Operating income 248.3m 225.0m 10% 156.5m 59% Operating margin 36.1% 30.5% 5.6ppt 27.5% 8.6ppt US GAAP diluted EPS 1.14 0.79 44% 0.65 75% Adjusted revenue 545.3m 603.6m (10%) 449.7m 21% Adjusted operating income 253.0m 269.3m (6%) 162.1m 56% Adjusted operating margin 46.4% 44.6% 1.8ppt 36.0% 10.4ppt Adjusted diluted EPS 1.16 1.16 0% 0.70 66% SUMMARY FINANCIAL RESULTS US GAAP and adjusted Note: See adjusted financial measures reconciliation on slides 31 and 32 for additional information.

14 REVENUE Q3 2021 adjusted revenue reflects higher average assets and seasonally lower performance fees Note: See adjusted financial measures reconciliation on slides 31 and 32 for additional information. 1 Net margin based on management fees net of distribution expenses. Adjusted revenue – Q2 2021 vs Q3 2021 (US$m) Q3 2021 adjusted revenue drivers ▪ Increase from Q2 2021 management fees driven by higher average assets ▪ Performance fees declined from Q2 2021 driven by investment performance and seasonality ▪ Average net management fee margin declined due to asset mix shift 511.5 494.5 0.6 77.4 12.2 10.9 21.0 20.8 545.3 603.6 Q3 2021 Q2 2021 Management fees Performance fees Shareowner servicing fees Other revenue (US$m, except margin data) Q3 2021 Q2 2021 Change Total adjusted revenue 545.3 603.6 (10%) Management fees 511.5 494.5 3% Performance fees 0.6 77.4 (99%) Shareowner servicing fees 12.2 10.9 12% Other revenue 21.0 20.8 1% Average net¹ mgmt fee margin 47.0bps 47.1bps (0.1bps)

15 ▪ Decrease in compensation expense primarily due to variable compensation and long-term incentive compensation ▪ Full-year 2021 expense expectations ▪ Adjusted compensation ratio now at the low end of the 40-42% range ▪ Adjusted non-compensation annual growth at the high end of the mid-single digits ▪ Statutory tax rate of 23-25% OPERATING EXPENSES Note: See adjusted financial measures reconciliation on slides 31 and 32 for additional information. Adjusted operating expenses – Q2 2021 vs Q3 2021 (US$m) 292.3 (26.2) (14.8) (0.1) (1.4) (0.3) 334.3 0.8 Q2 2021 Compensation and benefits LT incentive plans Investment administration Marketing General, admin. and occupancy Depreciation and amortisation Q3 2021 (US$m) Q3 2021 Q2 2021 Change Employee comp. and benefits 166.2 192.4 (14%) Long-term incentive plans 35.1 49.9 (30%) Total comp. expenses 201.3 242.3 (17%) Investment administration 13.0 13.1 (1%) Marketing 7.5 6.7 12% General, admin. and occup. 62.6 64.0 (2%) Depreciation and amortisation 7.9 8.2 (4%) Other operating expenses 91.0 92.0 (1%) Total operating expenses 292.3 334.3 (13%) Adjusted expenses reflect lower variable compensation primarily on seasonally lower performance fees Q3 2021 adjusted expense drivers

16 CAPITAL RESOURCES Strong liquidity position ▪ Cash and investment securities1 totalled US$1,197m compared to outstanding debt of US$311m ▪ Board declared a dividend of US$0.38 per share to be paid on 24 November to shareholders on record at the close of business on 8 November ▪ Repurchased 1.8m shares in 3Q 2021 for US$75m from the US$200m buyback programme authorised in July 2021 964.7 930.8 235.3 265.9 1,200.0 1,196.7 311.9 311.1 Cash and investments Debt Cash and investments Debt Balance sheet profile – carrying value 30 Jun 21 vs 30 Sep 21 (US$m) Investment securities¹ Cash and cash equivalents¹ 2025 maturity 30 Sep 21 30 Jun 21 1 Cash and cash equivalents and investment securities exclude those held by consolidated variable interest entities (‘VIEs’) and voting rights entities (‘VREs’), as they are not available for general corporate purposes. For additional detail, please see ‘Liquidity and Capital Resources’ portion of the Company’s Form 10‐Q for the period ended 30 September 2021.

Q&A

APPENDIX

19 ASSETS UNDER MANAGEMENT AUM as at 30 Sep 2021: US$419.3bn 56% 19% 13% 9% 3% Equities Fixed Income Multi-Asset Quantitative Equities Alternatives 49% 30% 21% Intermediary Institutional Self-Directed 56% 30% 14% North America EMEA & LatAm Asia Pacific By client type By capability By client location US$236.2bn US$79.5bn US$53.9bn US$39.1bn US$10.6bn US$206.7bn US$125.8bn US$86.8bn US$233.4bn US$128.1bn US$57.8bn

20 INVESTMENT MANAGEMENT CAPABILITIES Diversified product range Equities US$236.2bn AUM 30 Sep 21 US$419.3bn Fixed Income US$79.5bn Multi-Asset US$53.9bn Self-Directed Intermediary Institutional Institutional Institutional Quantitative Equities US$39.1bn Institutional Alternatives US$10.6bn Intermediary Equities ▪ Wide range of equity strategies encompassing different geographic focuses and investment styles Fixed Income ▪ Innovative and differentiated techniques designed to support clients as they navigate each unique economic cycle Multi-Asset ▪ Provides a range of diversified core investment solutions with the aim of delivering attractive returns over the long term with lower levels of volatility Quantitative Equities ▪ Intech applies advanced mathematics and systematic portfolio rebalancing intended to harness the volatility of movements in stock prices Alternatives ▪ Investment solutions aimed at delivering specific outcomes tailored to meet the needs and constraints of clients

21 LARGEST STRATEGIES BY CAPABILITY Note: Numbers may not cast due to rounding. Capability Strategy AUM (US$bn) 30 Sep 21 US Concentrated Growth 29.9 US Mid Cap Growth 29.9 US Research Growth Equity 21.6 Global Life Sciences 14.7 US SMID Cap Growth 13.3 Absolute Return Income 11.2 Global Strategic Fixed Income 10.3 Sterling Buy & Maintain Credit 9.3 Core Plus Fixed Income 7.1 Australian Fixed Income 6.2 Balanced 47.5 UK Cautious Managed 1.4 Global Adaptive Capital Appreciation 0.6 Multi Manager Managed 0.5 Protective Life Dynamic Allocation Series - Moderate 0.5 Intech Global Large Cap Core ex-Japan - ESG 12.1 Intech US Enhanced Plus 4.4 Intech Global Large Cap Core 4.4 Intech Global Enhanced Index ex-Australia ex-Tobacco 1% Risk 2.7 Intech US Broad Large Cap Growth 2.1 Absolute Return Equity 5.6 UK Direct Property 1.5 Multi Strategy 0.8 Europe Large Cap Long/Short 0.6 Global Equity Market Neutral 0.4 Total 238.7 Equity Fixed Income Multi-Asset Alternatives Quantitative Equities

22 5.8 10.3 10.5 8.6 7.5 (10.9) (10.4) (12.0) (10.5) (10.1) (5.1) (0.1) (1.5) (1.9) (2.6) Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Equities (US$bn) 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM. QUARTERLY FLOWS BY CAPABILITY Equities and Fixed Income 5.9 8.7 5.9 5.9 4.7 (4.1) (7.5) (5.5) (6.0) (4.0) 1.8 1.2 0.4 (0.1) 0.7 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 (24%) (22%) (22%) (19%) (17%) Redemptions Sales Net sales / (redemptions) Annualised gross redemptions¹ 13% 22% 19% 15% 12% 34% 46% 29% 30% 23% (23%) (40%) (28%) (31%) (19%) Fixed Income (US$bn) Annualised gross sales¹

23 1.3 0.3 0.2 0.2 0.1 (1.4) (3.7) (2.3) (1.5) (4.5) (0.1) (3.4) (2.1) (1.3) (4.4) Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 2.3 3.1 3.0 2.4 2.6 (1.7) (1.9) (2.2) (1.9) (1.8) 0.6 1.2 0.8 0.5 0.8 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 0.5 0.8 1.1 1.3 1.1 (0.6) (0.8) (2.0) (1.0) (0.8) (0.1) - (0.9) 0.3 0.3 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Multi-Asset (US$bn) 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM. QUARTERLY FLOWS BY CAPABILITY Multi-Asset, Quantitative Equities and Alternatives Redemptions Sales Net sales / (redemptions) Quantitative Equities (US$bn) 13% 3% 2% 2% 1% 22% 28% 25% 20% 20% 23% 33% 41% 52% 42% (14%) (36%) (22%) (14%) (41%) (17%) (17%) (18%) (15%) (14%) (24%) (31%) (77%) (39%) (30%) Annualised gross redemptions¹ Annualised gross sales¹ Alternatives (US$bn)

24 Q3 2019 Q4 2019 Q1 2020 Q2 2020 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Equities Fixed Income Multi-Asset Quantitative Equities Alternatives Q3 2019 to Q3 2021 total net flows by capability (US$bn) NET FLOWS BY CAPABILITY (12.2) (3.5) (6.7) (8.2) (2.9) (1.1) (3.3) (2.5) (5.2)

25 Note: Outperformance is measured based on composite performance gross of fees vs primary benchmark, except where a strategy has no benchmark index or corresponding composite in which case the most relevant metric is used: (1) composite gross of fees vs zero for absolute return strategies, (2) fund net of fees vs primary index or (3) fund net of fees vs Morningstar peer group average or median. Non-discretionary and separately managed account assets are included with a corresponding composite where applicable. Cash management vehicles, ETFs, Managed CDOs, Private Equity funds and custom non-discretionary accounts with no corresponding composite are excluded from the analysis. Excluded assets represent 5% of AUM across all time periods. Capabilities defined by Janus Henderson. INVESTMENT PERFORMANCE % of AUM outperforming benchmark Capability 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr Equities 54% 54% 67% 77% 55% 54% 69% 77% 56% 56% 55% 78% 64% 56% 60% 84% Fixed Income 92% 96% 90% 99% 94% 97% 89% 98% 98% 96% 97% 98% 98% 96% 96% 99% Multi-Asset 97% 96% 94% 96% 98% 97% 94% 96% 98% 97% 97% 96% 99% 97% 97% 97% Quantitative Equities 69% 24% 16% 69% 48% 4% 11% 72% 23% 23% 2% 71% 41% 2% 2% 32% Alternatives 97% 97% 100% 100% 98% 97% 100% 100% 98% 97% 100% 100% 94% 97% 100% 100% Total 68% 65% 72% 83% 67% 62% 70% 83% 66% 66% 63% 83% 72% 64% 67% 86% Q4 2020 Q1 2021 Q2 2021 Q3 2021

26 INVESTMENT PERFORMANCE Note: Includes Janus Investment Fund, Janus Aspen Series and Clayton Street Trust (US Trusts), Janus Henderson Capital Funds (Dublin based), Dublin and UK OEIC and Investment Trusts, Luxembourg SICAVs and Australian Managed Investment Schemes. The top two Morningstar quartiles represent funds in the top half of their category based on total return. For the 1-, 3-, 5- and 10-year periods ending 30 September 2021, 46%, 54%, 50% and 61% of the 195, 185, 180 and 150 total mutual funds, respectively, were in the top 2 Morningstar quartiles. Analysis based on ‘primary’ share class (Class I Shares, Institutional Shares or share class with longest history for US Trusts; Class A Shares or share class with longest history for Dublin based; primary share class as defined by Morningstar for other funds). Performance may vary by share class. Rankings may be based, in part, on the performance of a predecessor fund or share class and are calculated by Morningstar using a methodology that differs from that used by Janus Henderson. Methodology differences may have a material effect on the return and therefore the ranking. When an expense waiver is in effect, it may have a material effect on the total return, and therefore the ranking for the period. ETFs and funds not ranked by Morningstar are excluded from the analysis. Capabilities defined by Janus Henderson. © 2021 Morningstar, Inc. All Rights Reserved. % of mutual fund AUM in top 2 Morningstar quartiles Capability 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr Equities 47% 57% 67% 77% 35% 60% 64% 79% 32% 59% 44% 71% 47% 47% 49% 68% Fixed Income 70% 79% 73% 70% 69% 79% 73% 70% 57% 80% 75% 71% 84% 77% 73% 69% Multi-Asset 91% 91% 92% 93% 19% 91% 92% 96% 19% 92% 91% 93% 20% 92% 92% 94% Quantitative Equities 4% 33% 4% 2% 32% 32% 4% 0% 41% 47% 7% 0% 11% 11% 11% 0% Alternatives 74% 76% 75% 98% 30% 76% 30% 98% 27% 76% 27% 98% 27% 70% 74% 98% Total 57% 66% 71% 79% 37% 67% 68% 81% 33% 67% 55% 75% 47% 59% 60% 73% Q4 2020 Q1 2021 Q2 2021 Q3 2021

27 INVESTMENT PERFORMANCE % of mutual fund AUM in top 2 Morningstar quartiles (continued) Group 17 10 21 17 44 44 42 47 40 42 41 45 43 57 57 48 41 27 12 29 22 24 26 13 31 26 14 14 36 24 18 25 57 37 33 47 66 67 67 59 71 68 55 60 79 81 75 73 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Equities 10 8 22 19 29 27 26 32 27 32 31 31 34 53 54 37 36 27 10 28 29 32 33 15 40 32 14 17 44 27 18 31 47 35 32 47 57 60 59 47 67 64 44 49 77 79 71 68 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 2nd quartile 1st quartile 1-year 3-year 5-year Note: Full performance disclosures detailed on slide 26. Numbers may not cast due to rounding. 10-year 1-year 3-year 5-year 10-year

28 INVESTMENT PERFORMANCE % of mutual fund AUM in top 2 Morningstar quartiles (continued) 2nd quartile 1st quartile Fixed Income Multi-Asset 54 27 30 25 71 69 71 70 49 38 40 56 30 31 33 48 16 43 27 59 8 11 9 7 24 35 35 17 40 39 38 21 70 69 57 84 79 79 80 77 73 73 75 73 70 70 71 69 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 15 1 15 4 91 90 91 92 91 91 91 91 92 92 93 93 76 18 4 16 1 1 1 1 0 1 1 1 1 4 1 1 91 19 19 20 91 91 92 92 92 92 91 92 93 96 93 94 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 1-year 3-year 5-year 10-year 1-year 3-year 5-year 10-year Note: Full performance disclosures detailed on slide 26. Numbers may not cast due to rounding.

29 4 7 11 4 4 7 11 4 4 7 11 32 34 29 28 40 2 4 32 41 11 33 32 47 11 4 4 7 11 2 0 0 0 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 0 19 0 14 41 74 20 24 39 24 22 65 46 67 50 66 74 12 26 13 35 2 56 46 37 6 6 9 52 31 48 32 74 30 27 27 76 76 76 70 75 30 27 74 98 98 98 98 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2020 Q1 2021 Q2 2021 Q3 2021 INVESTMENT PERFORMANCE % of mutual fund AUM in top 2 Morningstar quartiles (continued) Quantitative Equities Alternatives 2nd quartile 1st quartile 1-year 3-year 5-year 10-year 1-year 3-year 5-year 10-year Note: Full performance disclosures detailed on slide 26. Numbers may not cast due to rounding.

30 US GAAP: STATEMENT OF INCOME (US$m, except per share data or as noted) 30 Sep 21 30 Jun 21 30 Sep 20 Revenue Management fees 564.5 544.1 457.7 Performance fees 0.6 77.4 7.0 Shareowner servicing fees 67.6 64.0 53.7 Other revenue 54.7 52.9 50.1 Total revenue 687.4 738.4 568.5 Operating expenses Employee compensation and benefits 166.2 192.4 154.9 Long-term incentive plans 35.0 49.8 42.7 Distribution expenses 142.1 134.8 118.8 Investment administration 13.0 13.1 13.1 Marketing 7.5 6.7 5.3 General, administrative and occupancy 65.5 65.7 65.6 Impairment of goodwill and intangible assets – 40.8 – Depreciation and amortisation 9.8 10.1 11.6 Total operating expenses 439.1 513.4 412.0 Operating income 248.3 225.0 156.5 Interest expense (3.2) (3.2) (3.2) Investment gains, net 4.7 1.8 25.5 Other non-operating income (expense), net 3.6 (2.7) (0.9) Income before taxes 253.4 220.9 177.9 Income tax provision (53.3) (79.7) (40.8) Net income 200.1 141.2 137.1 Net income attributable to noncontrolling interests (3.3) (3.9) (18.2) Net income attributable to JHG 196.8 137.3 118.9 Less: allocation of earnings to participating stock-based awards (5.4) (3.9) (3.5) Net income attributable to JHG common shareholders 191.4 133.4 115.4 Diluted weighted-average shares outstanding (m) 167.8 168.1 178.8 Diluted earnings per share (in US$) 1.14 0.79 0.65 3 months ended

31 ALTERNATIVE PERFORMANCE MEASURES Reconciliation of adjusted financial measures (US$m, except per share data) 30 Sep 21 30 Jun 21 31 Mar 21 31 Dec 20 30 Sep 20 30 Jun 20 Reconciliation of revenue to adjusted revenue Revenue 687.4 738.4 644.0 657.2 568.5 518.0 Management fees1 (53.0) (49.6) (46.8) (51.6) (47.9) (40.2) Shareowner servicing fees1 (55.4) (53.1) (50.0) (47.4) (42.8) (39.0) Other revenue1 (33.7) (32.1) (30.6) (29.7) (28.1) (25.5) Adjusted revenue 545.3 603.6 516.6 528.5 449.7 413.3 Reconciliation of operating expenses to adjusted operating expenses Operating expenses 439.1 513.4 451.5 430.2 412.0 411.3 Employee compensation and benefits2 –––(0.1) (0.3) (0.5) Long-term incentive plans2 0.1 0.1 0.1 0.1 0.1 0.2 Distribution expenses1 (142.1) (134.8) (127.4) (128.7) (118.8) (104.7) General, administrative and occupancy2 (2.9) (1.7) (3.6) (2.8) (3.5) (2.8) Impairment of goodwill and intangible assets3 –(40.8) (3.6) ––(26.4) Depreciation and amortisation3 (1.9) (1.9) (1.9) (1.9) (1.9) (2.2) Adjusted operating expenses 292.3 334.3 315.1 296.8 287.6 274.9 Adjusted operating income 253.0 269.3 201.5 231.7 162.1 138.4 Operating margin 36.1% 30.5% 29.9% 34.5% 27.5% 20.6% Adjusted operating margin 46.4% 44.6% 39.0% 43.8% 36.0% 33.5% 3 months ended Note: Reconciliation to be used in conjunction with slide 32. 1 JHG contracts with third-party intermediaries to distribute and service certain of its investment products. Fees for distribution and servicing related activities are either provided for separately in an investment product’s prospectus or are part of the management fee. Under both arrangements, the fees are collected by JHG and passed through to third-party intermediaries who are responsible for performing the applicable services. The majority of distribution and servicing fees collected by JHG are passed through to third-party intermediaries. JHG management believes that the deduction of distribution and service fees from revenue in the computation of adjusted revenue reflects the pass-through nature of these revenues. In certain arrangements, JHG performs the distribution and servicing activities and retains the applicable fees. Revenues for distribution and servicing activities performed by JHG are not deducted from GAAP revenue. 2 Adjustments primarily represent rent expense for subleased office space, a one-time charge related to the employee benefit trust, administrative costs related to Dai-ichi Life’s secondary offering as well as integration costs in related to the merger. JHG management believes these costs are not representative of the ongoing operations of the Group. 3 Investment management contracts have been identified as a separately identifiable intangible asset arising on the acquisition of subsidiaries and businesses. Such contracts are recognised at the net present value of the expected future cash flows arising from the contracts at the date of acquisition. For segregated mandate contracts, the intangible asset is amortised on a straight-line basis over the expected life of the contracts. Adjustments also include impairment charges of our goodwill and certain mutual fund investment management agreements, client relationships and trademarks. JHG management believes these non-cash and acquisition-related costs are not representative of the ongoing operations of the Group.

32 ALTERNATIVE PERFORMANCE MEASURES Reconciliation of adjusted financial measures (continued) (US$m, except per share data) 30 Sep 21 30 Jun 21 30 Sep 20 Reconciliation of net income attributable to JHG to adjusted net income attributable to JHG Net income attributable to JHG 196.8 137.3 118.9 Employee compensation and benefits2 –– 0.3 Long-term incentive plans2 (0.1) (0.1) (0.1) General, administrative and occupancy2 2.9 1.7 3.5 Impairment of goodwill and intangible assets3 – 40.8 – Depreciation and amortisation3 1.9 1.9 1.9 Other non-operating income (expense), net4 (1.6) (1.7) (0.5) Income tax benefit (provision)5 (0.4) 20.6 5.6 Adjusted net income attributable to JHG 199.5 200.5 129.6 Diluted earnings per share (in US$) 1.14 0.79 0.65 Adjusted diluted earnings per share (in US$) 1.16 1.16 0.70 3 months ended Note: Reconciliation to be used in conjunction with slide 31. 2 Adjustments primarily represent rent expense for subleased office space. In addition, the adjustment for the three months ended 30 September 2021 includes a one-time charge related to the employee benefits trust. JHG management believes these costs are not representative of the ongoing operations of the Group. 3 Investment management contracts have been identified as a separately identifiable intangible asset arising on the acquisition of subsidiaries and businesses. Such contracts are recognised at the net present value of the expected future cash flows arising from the contracts at the date of acquisition. For segregated mandate contracts, the intangible asset is amortised on a straight-line basis over the expected life of the contracts. Adjustments for the three months ended 30 June 2021 also include impairment charges of certain mutual fund investment management agreements. JHG management believes these non-cash and acquisition-related costs are not representative of the ongoing operations of the Group. 4 Adjustments primarily relate to contingent consideration adjustments associated with prior acquisitions. JHG management believes these costs are not representative of the ongoing operations of the Group. 5 The tax impact of the adjustments is calculated based on the applicable US or foreign statutory tax rate as it relates to each adjustment. Certain adjustments are either not taxable or not tax-deductible. Adjustments for the three months ended 30 June 2021 include a non-cash deferred tax expense of US$31.0 million due to the enactment of Finance Act 2021 during the second quarter 2021.

33 CAPITAL MANAGEMENT Note: JHG purchases shares on market for the annual share grants associated with variable compensation, which is not included in the above share repurchases. Numbers may not cast due to rounding. 1 Total shares outstanding reflect amounts disclosed on Forms 10-Q or 10-K for each respective quarter. 2 Cumulative decrease from commencement of buyback programme in Q3 2018. Continued commitment to return of capital Dividend paid / share (US$) 0.36 0.36 0.36 0.36 0.36 0.36 0.38 0.38 Shares repurchased (m) 0.5 2.1 1.1 2.4 1.0 8.1 0.0 1.8 Total shares outstanding1 (m) 187.0 184.9 183.9 181.4 180.4 172.3 172.3 170.6 Cumulative decrease in shares2 6.7% 7.7% 8.3% 9.5% 10.0% 14.0% 14.0% 14.9% Q4 2019 to Q3 2021 quarterly capital return (US$m) 66.3 66.2 66.1 65.8 64.8 61.7 65.0 64.8 12.5 31.2 22.0 50.2 27.4 230.2 75.0 78.8 97.4 88.1 116.0 92.2 291.9 65.0 139.8 Q4 2019 Q1 2020 Q2 2020 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Dividends Share repurchases

34 PERFORMANCE FEES Note: Performance fees include prior quarter accrual true-ups. 1 AUM data present US mutual fund AUM subject to performance fees as at 30 September 2021. Janus Investment Funds and Janus Aspen Series Portfolios are counted as distinct and separate funds. Q3 2021 (US$m) Q2 2021 (US$m) Q3 2020 (US$m) AUM generating Q3 2021 pfees (US$bn) # of funds generating Q3 2021 pfees Frequency Timing SICAVs 1.0 50.2 2.8 3.6 2 17 annually; 3 quarterly 17 at June; 3 on quarters UK OEICs and unit trusts – 15.2 6.4 –– annually various Offshore absolute return and other funds 1.1 0.2 0.1 0.1 1 quarterly / annually various Segregated mandates – 1.9 3.2 0.2 2 quarterly / annually various Investment trusts – 12.7 ––– annually various US mutual funds1 (1.5) (2.8) (5.5) 63.3 15 monthly monthly Total 0.6 77.4 7.0 67.2 20

35 US MUTUAL FUNDS WITH PERFORMANCE FEES Note: Numbers may not cast due to rounding. 1 The funds listed have a performance-based investment advisory fee that adjusts up or down based on performance relative to a benchmark over 36-month rolling periods. Please see the funds’ Statements of Additional Information for more details and benchmark information. 2 Adjustment of ± 15 bps assumes constant assets and could be higher or lower depending on asset fluctuations. 3 Until 1 August 2022, the Fund’s performance during the portion of the performance measurement period prior to 1 August 2019 will be compared to the Fund's former benchmark, the Russell 3000® Value Index. Mutual funds with performance fees¹ AUM 30 Sep 21 (US$m) Benchmark Base fee Performance fee2 Performance cap/(floor) vs benchmark Q3 2021 P&L impact (US$’000) Forty Fund and Portfolio 22,801 Russell 1000® Growth Index 0.64% ± 15 bps ± 8.50% 4,251 Research Fund and Portfolio 20,946 Russell 1000® Growth Index 0.64% ± 15 bps ± 5.00% (6,217) Contrarian Fund 5,087 S&P 500® Index 0.64% ± 15 bps ± 7.00% 1,198 Global Research Fund and Portfolio 4,380 MSCI World IndexSM 0.60% ± 15 bps ± 6.00% 758 Small Cap Value Fund 3,709 Russell 2000® Value Index 0.72% ± 15 bps ± 5.50% (1,260) Mid Cap Value Fund and Portfolio 2,855 Russell Midcap® Value Index 0.64% ± 15 bps ± 4.00% (1,155) Overseas Fund and Portfolio 2,511 MSCI All Country World ex-U.S. IndexSM 0.64% ± 15 bps ± 7.00% 758 Global Real Estate Fund 853 FTSE EPRA / NAREIT Global Index 0.75% ± 15 bps ± 4.00% 199 Small-Mid Cap Value Fund3 106 Russell 2500TM Value Index 0.70% ± 15 bps ± 5.00% (27) Asia Equity Fund 19 MSCI All Country Asia ex-Japan IndexSM 0.92% ± 15 bps ± 7.00% (12) Total 63,266 (1,506)

36 LONG-TERM INCENTIVE COMPENSATION Note: Annual grants generally vest over three and four years. Assumed no forfeitures in future periods. Assumed no change in future values related to market or currency, which would impact expense related to cash-based awards (MFSAs, DIP and DEP funds) and social security expense upon vesting. 1 Includes retention and recruiting awards; other subsidiary grants and social security expense. Social security expense is estimated based on amount of existing awards expected to vest in that year. Estimated future long-term incentive compensation amortization (US$m) Amount remaining to expense 2021 2022 2023 2024 2025 2018 annual grant 5 5 –––– 2019 annual grant 24 21 3 ––– 2020 annual grant 69 48 18 3 –– 2021 annual grant 140 71 46 20 3 – Other1 71 30 20 12 7 2 Total long-term incentive compensation 309 175 87 35 10 2

37 CONTACTS Investor enquiries Melanie Horton Co-Head Investor Relations (Non-US) +44 (0)20 7818 2905 [email protected] Jim Kurtz Co-Head Investor Relations (US) +1 303 336 4529 [email protected] Investor Relations [email protected] Media enquiries Stephen Sobey +44 (0)20 7818 2523 [email protected] Sarah Johnson +1 720 364 0708 [email protected] United Kingdom: Edelman Smithfield Latika Shah +44 (0)7950 671 948 [email protected] Andrew Wilde +44 (0)7786 022 022 [email protected] Asia Pacific: Honner Craig Morris +61 2 8248 3757 [email protected]

201 Bishopsgate London EC2M 3AE United Kingdom www.janushenderson.com Contact us Past performance is no guarantee of future results. Investing involves risk, including the possible loss of principal and fluctuation of value. Forward-looking information This presentation includes statements concerning potential future events involving Janus Henderson Group plc that could differ materially from the events that actually occur. The differences could be caused by a number of factors, including those factors identified in Janus Henderson Group’s Annual Report on Form 10-K for the fiscal year ended 31 December 2020 and the Company’s other filings and furnishings with the Securities and Exchange Commission (Commission file no. 001-38103), including those that appear under headings such as ‘Risk Factors’ and ‘Management’s Discussion and Analysis of Financial Condition and Results of Operations’. Many of these factors are beyond the control of the Company and its management. Any forward-looking statements contained in this presentation are as of the date on which such statements were made. The Company assumes no duty to update them, even if experience, unexpected events, or future changes make it clear that any projected results expressed or implied therein will not be realised. Annualised, pro forma, projected and estimated numbers are used for illustrative purposes only, are not forecasts and may not reflect actual results. No public offer The information, statements and opinions contained in this presentation do not constitute a public offer under any applicable legislation or an offer to sell or solicitation of any offer to buy any securities or financial instruments or any advice or recommendation with respect to such securities or other financial instruments. Not all products or services are available in all jurisdictions. Various account minimums or other eligibility qualifications apply depending on the investment strategy, vehicle or investor jurisdiction. Mutual funds in the US distributed by Janus Henderson Distributors. Please consider the charges, risks, expenses and investment objectives carefully before investing. For a US fund prospectus or, if available, a summary prospectus containing this and other information, please contact your investment professional or call 800.668.0434. Read it carefully before you invest or send money. Janus Henderson and Intech are trademarks of Janus Henderson Group plc or one of its subsidiaries. © Janus Henderson Group plc.


Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, $1.50 Per Share Par Value	JHG	New York Stock Exchange


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Exhibit Number		Description
99.1		Janus Henderson Group plc press release reporting its financial results for the third quarter 2021.
99.2		Janus Henderson Group plc third quarter 2021 earnings presentation.
104		Cover Page Interactive Data File - The cover page interactive data file does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document.


	Janus Henderson Group plc

Date: October 28, 2021	By:	/s/ Roger Thompson
		Roger Thompson
		Chief Financial Officer