Exhibit 99.1

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Janus Henderson Group plc Reports Fourth Quarter 2021 Results

and Announces Management-Led Buyout of Quantitative Equities Subsidiary Intech

●

Solid long-term investment performance, with 54%, 58%, 76% and 84% of assets under management (‘AUM’) outperforming relevant benchmarks on a one-, three-, five- and 10-year basis, respectively, as at 31 December 2021

●

Fourth quarter 2021 operating income was US$157.6 million; fourth quarter 2021 adjusted operating income of US$239.7 million increased 3% compared to the same period a year ago

●

Record AUM of US$432.3 billion increased 3% compared to the prior quarter, due to market performance partially offset by net outflows of US$(5.2) billion which were concentrated in Quantitative Equities

●

Completed US$66.9 million of share buybacks during the fourth quarter and the Board declared quarterly dividend of US$0.38 per share

●

Announces strategic decision to sell its Quantitative Equities subsidiary Intech Investment Management to a consortium of Intech management and certain non-executive directors

LONDON — Janus Henderson Group plc (NYSE/ASX: JHG; ‘Janus Henderson’, ‘JHG’, ‘the Group’) published its fourth quarter 2021 results for the period ended 31 December 2021.

Fourth quarter 2021 operating income was US$157.6 million compared to US$248.3 million in the third quarter 2021 and US$227.0 million in the fourth quarter 2020. Adjusted operating income, adjusted for one-time, acquisition and transaction related costs, was US$239.7 million in the fourth quarter 2021 compared to US$253.0 million in the third quarter 2021 and US$231.7 million in the fourth quarter 2020.

Fourth quarter 2021 diluted earnings per share of US$0.78 compared to US$1.14 in the third quarter 2021 and US$1.02 in the fourth quarter 2020. Adjusted diluted earnings per share of US$1.05 in the fourth quarter 2021 declined 9% compared to US$1.16 in the third quarter 2021 and increased 1% compared to US$1.04 in the fourth quarter 2020.

Management-Led Buyout of Quantitative Equities Subsidiary Intech

Janus Henderson today announced that it has made the strategic decision to sell its 97%-owned Quantitative Equities subsidiary, Intech Investment Management LLC (‘Intech’), to a consortium comprised of Intech management and certain non-executive directors (‘Management Buyout’). The Management Buyout is expected to enable both organisations to refocus on their key value propositions: Janus Henderson on providing active, fundamental investing; and Intech on delivering quantitative investment solutions for institutional investors. As part of this decision, JHG and Intech will enter into a transition services agreement that provides for continuation of support services to help ensure a seamless transition in operations and continuity in serving Intech’s clients. The transaction is expected to close in the first half of 2022.

With a focus on company strategy and execution, Jose Marques, PhD, former Head of Trading at Bridgewater Associates and current Chief Executive Officer at Entrypoint Capital, will join Intech as Chief Executive Officer. Adrian Banner, PhD, will continue to lead Intech’s investment teams and quantitative research initiatives as Chief Investment Officer. In addition to his current role as Chief Investment Strategist of Janus Henderson, Myron Scholes, PhD, will join the Intech Board in an advisory capacity.

Dick Weil, Chief Executive Officer of Janus Henderson Group plc, stated:

“2021 was a year of significant progress towards our strategy of Simple Excellence. We launched new products in focus areas of growth including active ETFs, ESG and Fixed Income. We strengthened our leadership with key hires. We improved our platform through significant technology and data upgrades, and the strategic decision to sell Intech further simplifies our operating model. We are pleased to have reached an agreement

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with Intech that benefits both firms, providing Janus Henderson with increased operating efficiency and focus on fundamental, active investment, while fulfilling Intech’s desire to operate independently in the delivery of quantitative investment solutions.

“Our dedicated focus on our clients produced good momentum in our business. Flows into Fixed Income and Multi-Asset capabilities were robust and we saw good client demand in our Intermediary channel, particularly in the EMEA & LatAm and Asia Pacific regions, which had net inflows for the year. Investment performance remained solid, and combined with favourable markets, increased AUM to a record US$432.3 billion at year end. Our financial results were strong. We continued to generate significant cash flow and increased capital returns to shareholders through both dividends and share buybacks. As we enter 2022, we believe that the significant progress towards our strategic objectives and the momentum in our business positions Janus Henderson well on the path to sustained growth.”

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SUMMARY OF FINANCIAL RESULTS (unaudited) (in US$ millions, except per share data or as noted)

The Group presents its financial results in US$ and in accordance with accounting principles generally accepted in the United States of America (‘US GAAP’ or ‘GAAP’). However, JHG management evaluates the profitability of the Group and its ongoing operations using additional non-GAAP financial measures. Management uses these performance measures to evaluate the business, and adjusted values are consistent with internal management reporting. See ‘Reconciliation of non-GAAP financial information’ below for additional information.


	Three months ended						Year ended
	31 Dec		30 Sep		31 Dec		31 Dec		31 Dec
	2021		2021		2020		2021		2020
GAAP basis:
Revenue	697.2		687.4		657.2		2,767.0		2,298.6
Operating expenses	539.6		439.1		430.2		1,943.6		2,140.8
Operating income	157.6		248.3		227.0		823.4		157.8
Operating margin	22.6	%	36.1	%	34.5	%	29.8	%	6.9	%
Net income attributable to JHG	132.5		196.8		186.8		622.1		161.6
Diluted earnings per share	0.78		1.14		1.02		3.59		0.87

Adjusted basis:
Revenue	549.9		545.3		528.5		2,215.4		1,834.2
Operating expenses	310.2		292.3		296.8		1,251.9		1,137.5
Operating income	239.7		253.0		231.7		963.5		696.7
Operating margin	43.6	%	46.4	%	43.8	%	43.5	%	38.0	%
Net income attributable to JHG	180.1		199.5		189.0		741.6		557.9
Diluted earnings per share	1.05		1.16		1.04		4.28		3.01

DIVIDEND AND SHARE BUYBACK

On 2 February 2022, the Board declared a fourth quarter dividend in respect of the three months ended 31 December 2021 of US$0.38 per share. Shareholders on the register on the record date of 14 February 2022 will be paid the dividend on 28 February 2022. Janus Henderson does not offer a dividend reinvestment plan.

As part of the US$200 million on-market buyback programme approved by the Board in July 2021, JHG purchased approximately 1.5 million of its ordinary shares on the NYSE and its CHESS Depositary Interests (CDIs) on the ASX in the fourth quarter, for a total outlay of US$66.9 million.

Net tangible assets per share


US$	31 Dec 2021	31 Dec 2020
Net tangible assets / (liabilities) per ordinary share	4.41	3.68

Net tangible assets are defined by the ASX as being total assets less intangible assets less total liabilities ranking ahead of, or equally with, claims of ordinary shares.

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AUM AND FLOWS (in US$ billions)

FX reflects movement in AUM resulting from changes in foreign currency rates as non-US$ denominated AUM is translated into US$. Redemptions include impact of client switches.

Total Group comparative AUM and flows


	Three months ended
	31 Dec	30 Sep	31 Dec
	2021	2021	2020
Opening AUM	419.3	427.6	358.3
Sales	19.3	16.0	23.2
Redemptions	(24.5)	(21.2)	(24.3)
Net sales / (redemptions)	(5.2)	(5.2)	(1.1)
Market / FX	18.2	(3.1)	44.4
Closing AUM	432.3	419.3	401.6

Quarterly AUM and flows by capability


		Fixed		Quantitative
	Equities	Income	Multi-Asset	Equities	Alternatives	Total
AUM 31 Dec 2020	219.4	81.5	48.0	42.0	10.7	401.6
Sales	10.5	5.9	3.0	0.2	1.1	20.7
Redemptions	(12.0)	(5.5)	(2.2)	(2.3)	(2.0)	(24.0)
Net sales / (redemptions)	(1.5)	0.4	0.8	(2.1)	(0.9)	(3.3)
Market / FX	7.0	(2.4)	0.7	1.4	0.1	6.8
AUM 31 Mar 2021	224.9	79.5	49.5	41.3	9.9	405.1
Sales	8.6	5.9	2.4	0.2	1.3	18.4
Redemptions	(10.5)	(6.0)	(1.9)	(1.5)	(1.0)	(20.9)
Net sales / (redemptions)	(1.9)	(0.1)	0.5	(1.3)	0.3	(2.5)
Market / FX	17.1	1.1	3.2	3.4	0.2	25.0
AUM 30 Jun 2021	240.1	80.5	53.2	43.4	10.4	427.6
Sales	7.5	4.7	2.6	0.1	1.1	16.0
Redemptions	(10.1)	(4.0)	(1.8)	(4.5)	(0.8)	(21.2)
Net sales / (redemptions)	(2.6)	0.7	0.8	(4.4)	0.3	(5.2)
Market / FX	(1.3)	(1.7)	(0.1)	0.1	(0.1)	(3.1)
AUM 30 Sep 2021	236.2	79.5	53.9	39.1	10.6	419.3
Sales	8.1	5.6	4.3	0.1	1.2	19.3
Redemptions	(11.3)	(5.5)	(2.2)	(4.3)	(1.2)	(24.5)
Net sales / (redemptions)	(3.2)	0.1	2.1	(4.2)	—	(5.2)
Market / FX	11.3	—	3.7	3.1	0.1	18.2
AUM 31 Dec 2021	244.3	79.6	59.7	38.0	10.7	432.3

Average AUM


	Three months ended
	31 Dec	30 Sep	31 Dec
	2021	2021	2020
Equities	243.0	243.5	204.1
Fixed Income	79.8	80.9	78.1
Multi-Asset	57.3	54.9	45.6
Quantitative Equities	38.7	41.9	40.8
Alternatives	10.6	10.7	10.4
Total	429.4	431.9	379.0

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INVESTMENT PERFORMANCE

% of AUM outperforming benchmark (at 31 December 2021)


Capability	1-year		3-year		5-year		10-year
Equities	39	%	37	%	68	%	81	%
Fixed Income	91	%	96	%	96	%	98	%
Multi-Asset	99	%	96	%	96	%	97	%
Quantitative Equities	8	%	58	%	53	%	21	%
Alternatives	91	%	100	%	100	%	100	%
Total	54	%	58	%	76	%	84	%

Outperformance is measured based on composite performance gross of fees vs primary benchmark, except where a strategy has no benchmark index or corresponding composite in which case the most relevant metric is used: (1) composite gross of fees vs zero for absolute return strategies, (2) fund net of fees vs primary index or (3) fund net of fees vs Morningstar peer group average or median. Non-discretionary and separately managed account assets are included with a corresponding composite where applicable.

Cash management vehicles, ETF-enhanced beta strategies, Managed CDOs, Private Equity funds and custom non-discretionary accounts with no corresponding composite are excluded from the analysis. Excluded assets represent 5% of AUM as at 31 December 2021. Capabilities defined by Janus Henderson.

% of mutual fund AUM in top 2 Morningstar quartiles (at 31 December 2021)


Capability	1-year		3-year		5-year		10-year
Equities	54	%	51	%	52	%	86	%
Fixed Income	64	%	81	%	75	%	70	%
Multi-Asset	95	%	93	%	93	%	94	%
Quantitative Equities	0	%	11	%	13	%	0	%
Alternatives	50	%	34	%	100	%	100	%
Total	62	%	61	%	64	%	86	%

Includes Janus Investment Fund, Janus Aspen Series and Clayton Street Trust (US Trusts), Janus Henderson Capital Funds (Dublin based), Dublin and UK OEIC and Investment Trusts, Luxembourg SICAVs and Australian Managed Investment Schemes. The top two Morningstar quartiles represent funds in the top half of their category based on total return. For the 1-, 3-, 5- and 10-year periods ending 31 December 2021, 43%, 57%, 55% and 64% of the 193, 184, 179 and 151 total mutual funds, respectively, were in the top 2 Morningstar quartiles.

Analysis based on ‘primary’ share class (Class I Shares, Institutional Shares or share class with longest history for US Trusts; Class A Shares or share class with longest history for Dublin based; primary share class as defined by Morningstar for other funds). Performance may vary by share class. Rankings may be based, in part, on the performance of a predecessor fund or share class and are calculated by Morningstar using a methodology that differs from that used by Janus Henderson. Methodology differences may have a material effect on the return and therefore the ranking. When an expense waiver is in effect, it may have a material effect on the total return, and therefore the ranking for the period.

FIRST QUARTER 2022 RESULTS

Janus Henderson intends to publish its first quarter 2022 results on 4 May 2022.

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FOURTH QUARTER AND FULL-YEAR 2021 RESULTS BRIEFING INFORMATION

Chief Executive Officer Dick Weil and Chief Financial Officer Roger Thompson will present these results on 3 February 2022 on a conference call and webcast to be held at 8am EST, 1pm GMT, 12am AEDT (4 February).

Those wishing to participate should call:


United Kingdom	0808 189 6484 (toll free)
United States	844 200 6205 (toll free)
Australia	02 7908 3093 (this is not toll free)
All other countries	+1 929 526 1599 (this is not toll free)
Conference ID	982643

Access to the webcast and accompanying slides will be available via the investor relations section of Janus Henderson’s website (ir.janushenderson.com).

About Janus Henderson

Janus Henderson Group is a leading global active asset manager dedicated to helping investors achieve long-term financial goals through a broad range of investment solutions, including equities, fixed income, quantitative equities, multi-asset and alternative asset class strategies.

At 31 December 2021, Janus Henderson had approximately US$432 billion in assets under management, more than 2,000 employees, and offices in 25 cities worldwide. Headquartered in London, the company is listed on the New York Stock Exchange (NYSE) and the Australian Securities Exchange (ASX).


Investor enquiries:		Media enquiries:
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[email protected]		[email protected]

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Co-Head Investor Relations (Non-US)		Director, Media Relations & Corp Comms
+44 (0)20 7818 2905		+1 720 364 0708
[email protected]		[email protected]

Or		United Kingdom: Edelman Smithfield
		Latika Shah
Investor Relations		+44 (0)7950 671 948
[email protected]		[email protected]

		Andrew Wilde
		+44 (0)7786 022 022
		[email protected]

		Asia Pacific: Honner
		Craig Morris
		+61 2 8248 3757
		[email protected]

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FINANCIAL DISCLOSURES

Condensed consolidated statements of comprehensive income (unaudited)


	Three months ended			Year ended
	31 Dec	30 Sep	31 Dec	31 Dec	31 Dec
(in US$ millions, except per share data or as noted)	2021	2021	2020	2021	2020
Revenue:
Management fees	565.9	564.5	489.1	2,189.4	1,794.1
Performance fees	7.7	0.6	59.3	102.7	98.1
Shareowner servicing fees	68.3	67.6	57.9	260.7	209.2
Other revenue	55.3	54.7	50.9	214.2	197.2
Total revenue	697.2	687.4	657.2	2,767.0	2,298.6

Operating expenses:
Employee compensation and benefits	160.1	166.2	162.3	693.3	618.6
Long-term incentive plans	42.7	35.0	44.7	181.0	170.1
Distribution expenses	147.3	142.1	128.7	551.6	464.4
Investment administration	12.9	13.0	12.6	51.6	50.0
Marketing	11.3	7.5	3.9	31.7	19.6
General, administrative and occupancy	77.6	65.5	66.4	271.8	255.2
Impairment of goodwill and intangible assets	77.5	—	—	121.9	513.7
Depreciation and amortisation	10.2	9.8	11.6	40.7	49.2
Total operating expenses	539.6	439.1	430.2	1,943.6	2,140.8

Operating income	157.6	248.3	227.0	823.4	157.8

Interest expense	(3.2)	(3.2)	(3.2)	(12.8)	(12.9)
Investment gains (losses), net	(7.3)	4.7	32.2	0.8	57.5
Other non-operating income (expense), net	8.0	3.6	(0.2)	8.8	39.7
Income before taxes	155.1	253.4	255.8	820.2	242.1
Income tax provision	(29.6)	(53.3)	(57.4)	(205.7)	(59.5)
Net income	125.5	200.1	198.4	614.5	182.6
Net loss (income) attributable to noncontrolling interests	7.0	(3.3)	(11.6)	7.6	(21.0)
Net income attributable to JHG	132.5	196.8	186.8	622.1	161.6
Less: allocation of earnings to participating stock-based awards	(3.6)	(5.4)	(5.5)	(17.7)	(4.7)
Net income attributable to JHG common shareholders	128.9	191.4	181.3	604.4	156.9

Basic weighted-average shares outstanding (in millions)	165.6	167.1	176.5	167.9	179.4
Diluted weighted-average shares outstanding (in millions)	166.2	167.8	177.0	168.5	179.9

Diluted earnings per share (in US$)	0.78	1.14	1.02	3.59	0.87

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Reconciliation of non-GAAP financial information

In addition to financial results reported in accordance with GAAP, we compute certain financial measures using non-GAAP components, as defined by the SEC. These measures are not in accordance with, or a substitute for, GAAP, and our financial measures may be different from non-GAAP financial measures used by other companies. We have provided a reconciliation of our non-GAAP components to the most directly comparable GAAP components. The following are reconciliations of US GAAP revenue, operating expenses, operating income, net income attributable to JHG and diluted earnings per share to adjusted revenue, adjusted operating expenses, adjusted operating income, adjusted net income attributable to JHG and adjusted diluted earnings per share.


	Three months ended						Year ended
	31 Dec		30 Sep		31 Dec		31 Dec		31 Dec
(in US$ millions, except per share data or as noted)	2021		2021		2020		2021		2020
Reconciliation of revenue to adjusted revenue
Revenue	697.2		687.4		657.2		2,767.0		2,298.6
Management fees¹	(56.5)		(53.0)		(51.6)		(205.9)		(183.8)
Shareowner servicing fees¹	(56.2)		(55.4)		(47.4)		(214.7)		(170.3)
Other revenue¹	(34.6)		(33.7)		(29.7)		(131.0)		(110.3)
Adjusted revenue	549.9		545.3		528.5		2,215.4		1,834.2

Reconciliation of operating expenses to adjusted operating expenses
Operating expenses	539.6		439.1		430.2		1,943.6		2,140.8
Employee compensation and benefits²	—		—		(0.1)		—		(2.3)
Long-term incentive plans²	0.1		0.1		0.1		0.4		0.5
Distribution expenses¹	(147.3)		(142.1)		(128.7)		(551.6)		(464.4)
General, administration and occupancy²	(2.6)		(2.9)		(2.8)		(10.8)		(11.0)
Impairment of goodwill and intangible assets³	(77.5)		—		—		(121.9)		(513.7)
Depreciation and amortisation³	(2.1)		(1.9)		(1.9)		(7.8)		(12.4)
Adjusted operating expenses	310.2		292.3		296.8		1,251.9		1,137.5

Adjusted operating income	239.7		253.0		231.7		963.5		696.7

Operating margin	22.6	%	36.1	%	34.5	%	29.8	%	6.9	%
Adjusted operating margin	43.6	%	46.4	%	43.8	%	43.5	%	38.0	%

Reconciliation of net income attributable to JHG to adjusted net income attributable to JHG
Net income attributable to JHG	132.5		196.8		186.8		622.1		161.6
Employee compensation and benefits²	—		—		0.1		—		2.3
Long-term incentive plans²	(0.1)		(0.1)		(0.1)		(0.4)		(0.5)
General, administration and occupancy²	2.6		2.9		2.8		10.8		11.0
Impairment of goodwill and intangible assets³	77.5		—		—		121.9		513.7
Depreciation and amortisation³	2.1		1.9		1.9		7.8		12.4
Interest expense⁴	—		—		—		—		0.1
Investment gains (losses), net⁴	—		—		(1.4)		0.2		(1.4)
Other non-operating income (expense), net⁴	(9.1)		(1.6)		(1.7)		(14.2)		(28.7)
Income tax benefit (provision)⁵	(25.4)		(0.4)		0.6		(6.6)		(112.6)
Adjusted net income attributable to JHG	180.1		199.5		189.0		741.6		557.9
Less: allocation of earnings to participating stock-based awards	(5.0)		(5.5)		(5.5)		(21.1)		(16.4)
Adjusted net income attributable to JHG common shareholders	175.1		194.0		183.5		720.5		541.5

Weighted-average diluted common shares outstanding – diluted (two class) (in millions)	166.2		167.8		177.0		168.5		179.9
Diluted earnings per share (two class) (in US$)	0.78		1.14		1.02		3.59		0.87
Adjusted diluted earnings per share (two class) (in US$)	1.05		1.16		1.04		4.28		3.01

1	JHG contracts with third-party intermediaries to distribute and service certain of its investment products. Fees for distribution and servicing related activities are either provided for separately in an investment product’s prospectus or are part of the management fee.

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Under both arrangements, the fees are collected by JHG and passed through to third-party intermediaries who are responsible for performing the applicable services. The majority of distribution and servicing fees collected by JHG are passed through to third-party intermediaries. JHG management believes that the deduction of distribution and service fees from revenue in the computation of adjusted revenue reflects the pass-through nature of these revenues. In certain arrangements, JHG performs the distribution and servicing activities and retains the applicable fees. Revenues for distribution and servicing activities performed by JHG are not deducted from GAAP revenue.

Adjustments primarily represent rent expense for subleased office space. In addition, the adjustments for the three months ended 30 September 2021 and the year ended 31 December 2021 include a one-time charge related to the employee benefits trust. JHG management believes these costs are not representative of the ongoing operations of the Group.

Investment management contracts have been identified as a separately identifiable intangible asset arising on the acquisition of subsidiaries and businesses. Such contracts are recognised at the net present value of the expected future cash flows arising from the contracts at the date of acquisition. For segregated mandate contracts, the intangible asset is amortised on a straight-line basis over the expected life of the contracts. Adjustments also include impairment charges of our goodwill and certain mutual fund investment management agreements, client relationships and trademarks. JHG management believes these non-cash and acquisition-related costs are not representative of the ongoing operations of the Group.

4	Adjustments primarily represent contingent consideration adjustments associated with prior acquisitions. JHG management believes these costs are not representative of the ongoing operations of the Group.

5	The tax impact of the adjustments is calculated based on the applicable US or foreign statutory tax rate as it relates to each adjustment. Certain adjustments are either not taxable or not tax-deductible.

Condensed consolidated balance sheets (unaudited)


	31 Dec	31 Dec
(in US$ millions)	2021	2020
Assets:
Cash and cash equivalents	1,107.3	1,099.7
Investment securities	451.4	268.1
Property, equipment and software, net	63.3	77.9
Intangible assets and goodwill, net	3,917.0	4,070.2
Assets of consolidated variable interest entities	264.3	226.5
Other assets	932.4	948.4
Total assets	6,735.7	6,690.8

Liabilities, redeemable noncontrolling interests and equity:
Long-term debt	310.4	313.3
Deferred tax liabilities, net	619.2	627.4
Liabilities of consolidated variable interest entities	2.6	3.2
Other liabilities	976.9	927.3
Redeemable noncontrolling interests	163.4	85.8
Total equity	4,663.2	4,733.8
Total liabilities, redeemable noncontrolling interests and equity	6,735.7	6,690.8

Condensed consolidated statements of cash flows (unaudited)


	Three months ended
	31 Dec	30 Sep	31 Dec
(in US$ millions)	2021	2021	2020
Cash provided by (used for):
Operating activities	281.2	319.4	220.2
Investing activities	(17.5)	(222.9)	119.4
Financing activities	(90.7)	(112.9)	(191.2)
Effect of exchange rate changes	1.0	(16.3)	33.2
Net change during period	174.0	(32.7)	181.6

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STATUTORY DISCLOSURES

Associates and joint ventures

At 31 December 2021, the Group holds interests in the following associates and joint ventures managed through shareholder agreements with third party investors, accounted for under the equity method:

●

LongTail Alpha LLC ownership 20%

Basis of preparation

In the opinion of management of Janus Henderson Group plc, the condensed consolidated financial statements contain all normal recurring adjustments necessary to fairly present the financial position, results of operations and cash flows of JHG in accordance with US GAAP. Such financial statements have been prepared in accordance with the instructions to Form 10-Q pursuant to the rules and regulations of the SEC. Certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. The financial statements should be read in conjunction with the annual consolidated financial statements and notes presented in Janus Henderson Group’s Annual Report on Form 10-K for the year ended 31 December 2020, on file with the SEC (Commission file no. 001-38103). Events subsequent to the balance sheet date have been evaluated for inclusion in the financial statements through the issuance date and are included in the notes to the condensed consolidated financial statements.

Corporate governance principles and recommendations

In the opinion of the Directors, the financial records of the Group have been properly maintained, and the Condensed Consolidated Financial Statements comply with the appropriate accounting standards and give a true and fair view of the financial position and performance of the Group. This opinion has been formed on the basis of a sound system of risk management and internal control which is operating effectively.

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FORWARD-LOOKING STATEMENTS DISCLAIMER

Past performance is no guarantee of future results. Investing involves risk, including the possible loss of principal and fluctuation of value.

This document includes statements concerning potential future events involving Janus Henderson Group plc that could differ materially from the events that actually occur. The differences could be caused by a number of factors, including those factors identified in Janus Henderson Group’s Annual Report on Form 10-K for the fiscal year ended 31 December 2020 and in other filings or furnishings made by the Company with the Securities and Exchange Commission from time to time (Commission file no. 001-38103), including those that appear under headings such as ‘Risk Factors’ and ‘Management’s Discussion and Analysis of Financial Condition and Results of Operations’. Many of these factors are beyond the control of JHG and its management. Any forward-looking statements contained in this document are as at the date on which such statements were made. Janus Henderson Group undertakes no obligation to publicly update or revise any forward-looking statements after the date they are made, whether as a result of new information, future events or otherwise, except as required by law.

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Exhibit 99.2

Thursday 3 February 2022 FOURTH QUARTER AND FULL - YEAR 2021 RESULTS Dick Weil Chief Executive Officer Roger Thompson Chief Financial Officer

2021 RESULTS AND PROGRESS Dick Weil Chief Executive Officer

3 1 Represents percentage of AUM outperforming the relevant benchmark. Full performance disclosures detailed in the appendix on s li de 27. 2 See adjusted financial measures reconciliation on slides 33 and 34 for additional information. FULL - YEAR 2021 RESULTS ▪ Long - term investment performance remained solid despite volatile markets ▪ AUM increased 8% in 2021 to US$432bn; strength in global markets was partially offset by net outflows ▪ Flows excluding Quantitative Equities improved significantly during the year, with outflows of US$4.2bn and US$15.0bn in 2021 and 2020, respectively ▪ Adjusted diluted EPS of US$4.28 in 2021 improved 42% over 2020 ▪ Returned US$628m in capital through dividends and share buybacks in 2021 2021 2020 3 - year investment out performance ¹ 58% 65% Net flows US$(16.2)bn US$(24.4)bn Total AUM US$432.3bn US$401.6bn US GAAP diluted EPS US$3.59 US$0.87 Adjusted diluted EPS² US$4.28 US$3.01 D ividend per share US$1.50 US$1.44 Key metrics – 2021 vs 2020

4 2021 PROGRESS AND UPDATE ON INTECH Strengthened operating platform for sustained organic and inorganic growth Produce dependable investment outcomes ✓ Long - term investment performance remains solid; more than half of AUM outperforming benchmarks on a 1 - , 3 - and 5 - year basis ¹ ✓ Improved investment results in pockets of underperformance Excel in distribution and client experience ✓ Multiple leadership appointments across key distribution roles and geographies ✓ Growth in net flows in the Intermediary channel Focus and in crease operational efficiency ✓ New Chief Operating Officer appointment ✓ Significant technology and data upgrades ✓ Simplified operating model, including agreed sale of Intech Proactive r isk and control e nvironment ✓ Strengthened risk model and relationships with regulators – lower capital requirements Develop n ew g rowth initiatives ✓ Innovative ETF launches ✓ Model portfolio expansion ✓ Significant investment in ESG products, resourcing and data 1 Represents percentage of AUM outperforming the relevant benchmark. Full performance disclosures detailed in the appendix on s lid e 27.

BUSINESS AND FINANCIAL UPDATE Roger Thompson Chief Financial Officer

6 1 Represents percentage of AUM outperforming the relevant benchmark. Full performance disclosures detailed in the appendix on s li de 27. 2 See adjusted financial measures reconciliation on slides 33 and 34 for additional information. Key metrics – Q4 2021 vs Q3 2021 Q4 2021 RESULTS ▪ Long - term investment performance remains solid ▪ AUM increased 3% to US$432bn, primarily due to markets ▪ Adjusted diluted EPS of US$1.05 declined 9% versus Q3 2021 and increased 1% versus Q4 2020 ▪ Declared US$0.38 per share dividend and completed US$67m of share buybacks Q4 2021 Q3 2021 3 - year investment out performance ¹ 58% 64% Net flows US$(5.2)bn US$(5.2)bn Total AUM US$432.3bn US$419.3bn US GAAP diluted EPS US$0.78 US$1.14 Adjusted diluted EPS² US$1.05 US$1.16 D ividend per share US$0.38 US$0.38

7 Capability 1 - year 3 - year 5 - year 10 - year Equities Fixed Income Multi - Asset Quantitative Equities Alternatives Total Excl. Quantitative Equities Capability 1 - year 3 - year 5 - year 10 - year Equities Fixed Income Multi - Asset Quantitative Equities Alternatives Total Excl. Quantitative Equities Note: Full performance disclosures detailed in the appendix on slides 27 and 28. The top two Morningstar quartiles represent funds in the top half of their category based on total return. The top quartile r ep resents those in the top 25%. Refer to slide 28 for the percent of funds in the top 2 quartiles for all periods and description and quantity of funds included in the analysi s; refer to slides 29 to 31 for distribution across first and second quartiles. Past performance is no guarantee of future results. 58% 58% 86% 78% INVESTMENT PERFORMANCE % of mutual fund AUM in top 2 Morningstar quartiles As at 31 Dec 21 % of AUM outperforming benchmark As at 31 Dec 21 8% 58% 53% 76% 58% 54% 100% 100% 91% 96% 96% 99% 96% 96% 91% 68% 37% 39% 0% 11% 13% 64% 61% 62% 100% 34% 50% 93% 93% 95% 75% 81% 64% 52% 51% 54% ▪ 44% of mutual fund AUM is in the top Morningstar quartile on a 3 - and 5 - year basis, as at 31 December 2021 Long - term investment performance remains solid 21% 84% 100% 97% 98% 81% 0% 86% 100% 94% 70% 86% 63% 61% 86% 64%

8 18.7 21.4 17.9 15.8 23.2 20.7 18.4 16.0 19.3 (25.4) (33.6) (26.1) (18.7) (24.3) (24.0) (20.9) (21.2) (24.5) (6.7) (12.2) (8.2) (2.9) (1.1) (3.3) (2.5) (5.2) (5.2) Q4 2019 Q1 2020 Q2 2020 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q4 2019 to Q4 2021 total flows (US$bn) Redemptions Sales Net sales / (redemptions) 21% 23% 25% 19% 26% 21% 18% 15% 18% Annualised gross sales¹ Annualised gross redemptions¹ 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM. TOTAL FLOWS Net outflows are unchanged compared to the prior quarter (29%) (36%) (36%) (22%) (27%) (24%) (21%) (20%) (23%)

9 18.4 21.0 17.5 14.5 22.9 20.5 18.2 15.9 19.2 (21.8) (31.2) (21.8) (17.3) (20.6) (21.7) (19.4) (16.7) (20.2) (3.4) (10.2) (4.3) (2.8) 2.3 (1.2) (1.2) (0.8) (1.0) Q4 2019 Q1 2020 Q2 2020 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q4 2019 to Q4 2021 total flows (US$bn) Redemptions Sales Net sales / (redemptions) 23% 26% 27% 19% 29% 23% 20% 16% 20% Annualised gross sales¹ Annualised gross redemptions¹ TOTAL FLOWS EXCLUDING QUANTITATIVE EQUITIES Net flows remained stable as increased redemptions offset higher sales (28%) (38%) (34%) (23%) (26%) (24%) (21%) (17%) (21%) Note: See total quarterly flows including Quantitative Equities on slide 8. 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM.

10 8.6 3.2 4.0 2.4 4.2 (6.5) (4.7) (4.7) (3.9) (4.3) 2.1 (1.5) (0.6) (1.5) (0.1) Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 13.4 16.4 13.5 12.8 14.0 (12.4) (15.3) (13.3) (11.6) (14.1) 1.1 1.1 0.1 1.2 (0.1) Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 0.9 0.9 0.7 0.7 1.0 (1.7) (1.8) (1.4) (1.2) (1.7) (0.9) (0.9) (0.7) (0.6) (0.8) Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Intermediary (US$bn) QUARTERLY FLOWS BY CLIENT TYPE EXCLUDING QUANTITATIVE EQUITIES Redemptions Sales Net sales / (redemptions) Institutional (US$bn) 44% 15% 18% 10% 19% 32% 35% 28% 25% 27% 5% 4% 4% 3% 4% (33%) (21%) (21%) (17%) (19%) (29%) (32%) (28%) (22%) (27%) (10%) (9%) (7%) (6%) (8%) Annualised gross redemptions¹ Annualised gross sales¹ Self - Directed (US$bn) Net flows reflect improvement in Institutional and a decline in Intermediary Note: See quarterly flows by client type including Quantitative Equities on slide 23. Numbers may not cast due to rounding. 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM.

11 Q4 2021 FLOWS BY CAPABILITY EXCLUDING QUANTITATIVE EQUITIES Net flows reflect strength in Fixed Income and Multi - Asset 8.1 5.6 4.3 1.2 (11.3) (5.5) (2.2) (1.2) (3.2) 0.1 2.1 - Equities Fixed Income Multi-Asset Alternatives Annualised gross sales¹ Redemptions Sales Net sales / (redemptions) 14% 28% 31% 44% Annualised gross redemptions¹ (19%) (28%) (16%) (43%) Q4 2021 flows by capability (US$bn) Note: See Quantitative Equities quarterly flows on slide 25. 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM.

12 US GAAP Adjustments Adjusted US GAAP Adjustments Adjusted Revenue Management fees 565.9 (56.5) 509.4 2,189.4 (205.9) 1,983.5 Performance fees 7.7 – 7.7 102.7 – 102.7 Shareowner servicing fees 68.3 (56.2) 12.1 260.7 (214.7) 46.0 Other revenue 55.3 (34.6) 20.7 214.2 (131.0) 83.2 Total revenue 697.2 (147.3) 549.9 2,767.0 (551.6) 2,215.4 Operating expenses Employee compensation and benefits 160.1 – 160.1 693.3 – 693.3 Long-term incentive plans 42.7 0.1 42.8 181.0 0.4 181.4 Distribution expenses 147.3 (147.3) – 551.6 (551.6) – Investment administration 12.9 – 12.9 51.6 – 51.6 Marketing 11.3 – 11.3 31.7 – 31.7 General, administrative and occupancy 77.6 (2.6) 75.0 271.8 (10.8) 261.0 Impairment of goodwill and intangible assets 77.5 (77.5) – 121.9 (121.9) – Depreciation and amortisation 10.2 (2.1) 8.1 40.7 (7.8) 32.9 Total operating expenses 539.6 (229.4) 310.2 1,943.6 (691.7) 1,251.9 Operating income 157.6 82.1 239.7 823.4 140.1 963.5 3 months ended 31 Dec 21 Year ended 31 Dec 21 (US$m) STATEMENT OF INCOME US GAAP and adjusted Note: See adjusted financial measures reconciliation on slides 33 and 34 for additional information.

13 (US$, except margin data) Q4 2021 Q3 2021 Change Q4 2021 vs Q3 2021 2021 2020 Change 2021 vs 2020 Average AUM 429.4bn 431.9bn (1%) 422.0bn 352.7bn 20% Total revenue 697.2m 687.4m 1% 2,767.0m 2,298.6m 20% Operating income 157.6m 248.3m (37%) 823.4m 157.8m nm Operating margin 22.6% 36.1% (13.5ppt) 29.8% 6.9% 22.9ppt US GAAP diluted EPS 0.78 1.14 (32%) 3.59 0.87 nm Adjusted revenue 549.9m 545.3m 1% 2,215.4m 1,834.2m 21% Adjusted operating income 239.7m 253.0m (5%) 963.5m 696.7m 38% Adjusted operating margin 43.6% 46.4% (2.8ppt) 43.5% 38.0% 5.5ppt Adjusted diluted EPS 1.05 1.16 (9%) 4.28 3.01 42% SUMMARY FINANCIAL RESULTS US GAAP and adjusted Note: See adjusted financial measures reconciliation on slides 33 and 34 for additional information.

14 REVENUE Q4 2021 adjusted revenue up 1% quarter over quarter Note: See adjusted financial measures reconciliation on slides 33 and 34 for additional information. 1 Net margin based on management fees net of distribution expenses. Adjusted revenue – Q3 2021 vs Q4 2021 (US$m) Q4 2021 adjusted revenue drivers 509.4 511.5 7.7 0.6 12.1 12.2 20.7 21.0 549.9 545.3 Q4 2021 Q3 2021 Management fees Performance fees Shareowner servicing fees Other revenue (US$m, except margin data) Q4 2021 Q3 2021 Change Total adjusted revenue 549.9 545.3 1% Management fees 509.4 511.5 (0%) Performance fees 7.7 0.6 nm Shareowner servicing fees 12.1 12.2 (1%) Other revenue 20.7 21.0 (1%) Average net¹ mgmt fee margin 47.0bps 47.0bps 0.0bps Capability 2021 2020 Change Equities 56.1 55.8 1% Fixed Income 29.1 27.7 5% Multi - Asset 52.9 52.1 2% Quantitative Equities 16.5 18.7 (12%) Alternatives 68.4 66.3 3% Total 47.0 45.6 3% Excl. Quantitative Equities 50.3 49.1 2% Annual average net 1 mgmt. fee margin (bps)

15 ▪ Change in compensation expense primarily due to long - term incentive compensation offset by lower variable compensation ▪ Higher other operating expenses driven by marketing, general and administrative expenses ▪ Full - year 2022 expense expectations ▪ Adjusted compensation ratio of low 40s ▪ Adjusted non - compensation annual growth in the low teens ▪ Statutory tax rate of 23 - 25% OPERATING EXPENSES Note: See adjusted financial measures reconciliation on slides 33 and 34 for additional information. Adjusted operating expenses – Q3 2021 vs Q4 2021 (US$m) 310.2 292.3 7.7 3.8 12.4 0.2 (6.1) (0.1) Q3 2021 Compensation and benefits LT incentive plans Investment administration Marketing General, admin. and occupancy Depreciation and amortisation Q4 2021 (US$m) Q4 2021 Q3 2021 Change Employee comp. and benefits 160.1 166.2 (4%) Long-term incentive plans 42.8 35.1 22% Total comp. expenses 202.9 201.3 1% Investment administration 12.9 13.0 (1%) Marketing 11.3 7.5 51% General, admin. and occup. 75.0 62.6 20% Depreciation and amortisation 8.1 7.9 3% Other operating expenses 107.3 91.0 18% Total operating expenses 310.2 292.3 6% Adjusted expenses primarily reflect higher other operating expenses Q4 2021 adjusted expense drivers

16 CAPITAL RESOURCES Strong liquidity position ▪ Cash and investment securities 1 totalled US$1,657m compared to outstanding debt of US$310m ▪ Increase in investment securities due to net seed investment ▪ Board declared a dividend of US$0.38 per share to be paid on 28 February to shareholders on record at the close of business on 14 February ▪ Repurchased 1.5m shares in Q4 2021 for US$67m from the US$200m buyback programme authorised in July 2021 1,096.9 1,106.0 407.6 551.0 1,504.5 1,657.0 313.3 310.4 Cash and investments Debt Cash and investments Debt Balance sheet profile – carrying value 31 Dec 20 vs 31 Dec 21 (US$m) Investment securities¹ Cash and cash equivalents¹ 2025 maturity 31 Dec 21 31 Dec 20 1 Cash and cash equivalents exclude cash associated with consolidated VIEs and VREs, and investment securities exclude non - control ling interests.

Q&A

APPENDIX

19 ASSETS UNDER MANAGEMENT AUM as at 31 Dec 2021: US$432.3bn 57% 18% 14% 9% 2% Equities Fixed Income Multi-Asset Quantitative Equities Alternatives 50% 29% 21% Intermediary Institutional Self-Directed 56% 30% 14% North America EMEA & LatAm Asia Pacific By client type By capability By client location US$244.3bn US$79.6bn US$59.7bn US$38.0bn US$10.7bn US$215.0bn US$127.2bn US$90.1bn US$241.0bn US$132.3bn US$59.0bn

20 ASSETS UNDER MANAGEMENT EXCLUDING QUANTITATIVE EQUITIES AUM excluding Quantitative Equities as at 31 Dec 2021: US$394.3bn 62% 20% 15% 3% Equities Fixed Income Multi-Asset Alternatives 54% 23% 23% Intermediary Institutional Self-Directed 56% 30% 14% North America EMEA & LatAm Asia Pacific By client type By capability By client location US$244.3bn US$79.6bn US$59.7bn US$10.7bn US$213.3bn US$91.6bn US$89.6bn US$227.8bn US$128.5bn US$38.1bn Note: Numbers may not cast due to rounding.

21 INVESTMENT MANAGEMENT CAPABILITIES Diversified product range Equities US$244.3bn AUM 31 Dec 21 US$432.3bn Fixed Income US$79.6bn Multi - Asset US$59.7bn Self - Directed Intermediary Institutional Institutional Quantitative Equities US$38.0bn Institutional Alternatives US$10.7bn Intermediary Equities (56bps 1 ) ▪ Wide range of equity strategies encompassing different geographic focuses and investment styles Fixed Income (29bps 1 ) ▪ Innovative and differentiated techniques designed to support clients as they navigate each unique economic cycle Multi - Asset (53bps 1 ) ▪ Provides a range of diversified core investment solutions with the aim of delivering attractive returns over the long term with lower levels of volatility Quantitative Equities (17bps 1 ) ▪ Intech applies advanced mathematics and systematic portfolio rebalancing intended to harness the volatility of movements in stock prices Alternatives (68bps 1 ) ▪ Investment solutions aimed at delivering specific outcomes tailored to meet the needs and constraints of clients 1 Full - year 2021 average net management fee margin; net margin based on management fees net of distribution expenses.

22 LARGEST STRATEGIES BY CAPABILITY Note: Numbers may not cast due to rounding. Capability Strategy AUM (US$bn) 31 Dec 21 US Concentrated Growth 31.3 US Mid Cap Growth 29.9 US Research Growth Equity 22.9 Global Life Sciences 15.0 US SMID Cap Growth 12.8 Global Strategic Fixed Income 10.7 Absolute Return Income 10.3 Sterling Buy & Maintain Credit 9.6 Core Plus Fixed Income 7.0 Australian Fixed Income 6.4 Balanced 52.3 UK Cautious Managed 1.4 Adaptive Portable Alpha 0.9 Global Adaptive Capital Appreciation 0.6 Protective Life Dynamic Allocation Series - Moderate 0.5 Intech Global Large Cap Core ex-Japan - ESG 13.0 Intech US Enhanced Plus 4.1 Intech Global Enhanced Index ex-Australia ex-Tobacco 1% Risk 2.8 Intech Global Large Cap Core 2.3 Intech US Broad Equity Plus 2.0 Absolute Return Equity 5.3 UK Direct Property 1.5 Multi Strategy 1.1 Europe Large Cap Long/Short 0.7 Concentrated Pan Europe Equity 0.4 Total 245.2 Equity Fixed Income Multi-Asset Alternatives Quantitative Equities

23 8.8 3.3 4.2 2.5 4.3 (10.0) (6.8) (6.0) (8.3) (8.5) (1.2) (3.5) (1.8) (5.8) (4.2) Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 13.5 16.5 13.5 12.9 14.0 (12.5) (15.4) (13.5) (11.7) (14.2) 1.0 1.1 - 1.2 (0.2) Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 0.9 0.9 0.7 0.6 1.0 (1.8) (1.8) (1.4) (1.2) (1.8) (0.9) (0.9) (0.7) (0.6) (0.8) Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Intermediary (US$bn) 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM. QUARTERLY FLOWS BY CLIENT TYPE Redemptions Sales Net sales / (redemptions) Institutional (US$bn) 30% 11% 13% 7% 14% 32% 35% 28% 25% 27% 5% 4% 4% 3% 4% (34%) (22%) (19%) (25%) (27%) (29%) (32%) (28%) (23%) (27%) (10%) (9%) (7%) (6%) (8%) Annualised gross redemptions¹ Annualised gross sales¹ Self - Directed (US$bn)

24 10.3 10.5 8.6 7.5 8.1 (10.4) (12.0) (10.5) (10.1) (11.3) (0.1) (1.5) (1.9) (2.6) (3.2) Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Equities (US$bn) 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM. QUARTERLY FLOWS BY CAPABILITY Equities and Fixed Income 8.7 5.9 5.9 4.7 5.6 (7.5) (5.5) (6.0) (4.0) (5.5) 1.2 0.4 (0.1) 0.7 0.1 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 (22%) (22%) (19%) (17%) (19)% Redemptions Sales Net sales / (redemptions) Annualised gross redemptions¹ 22% 19% 15% 12% 14% 46% 29% 30% 23% 28% (40%) (28%) (31%) (19%) (28)% Fixed Income (US$bn) Annualised gross sales¹

25 0.3 0.2 0.2 0.1 0.1 (3.7) (2.3) (1.5) (4.5) (4.3) (3.4) (2.1) (1.3) (4.4) (4.2) Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 3.1 3.0 2.4 2.6 4.3 (1.9) (2.2) (1.9) (1.8) (2.2) 1.2 0.8 0.5 0.8 2.1 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 0.8 1.1 1.3 1.1 1.2 (0.8) (2.0) (1.0) (0.8) (1.2) - (0.9) 0.3 0.3 - Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Multi - Asset (US$bn) 1 Annualised gross sales and redemption rates calculated as a percentage of beginning period AUM. QUARTERLY FLOWS BY CAPABILITY Multi - Asset, Quantitative Equities and Alternatives Redemptions Sales Net sales / (redemptions) Quantitative Equities (US$bn) 3% 2% 2% 1% 2% 28% 25% 20% 20% 31% 33% 41% 52% 42% 44% (36%) (22%) (14%) (41%) (44%) (17%) (18%) (15%) (14%) (16%) (31%) (77%) (39%) (30%) (43%) Annualised gross redemptions¹ Annualised gross sales¹ Alternatives (US$bn)

26 Q4 2019 Q1 2020 Q2 2020 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Equities Fixed Income Multi-Asset Quantitative Equities Alternatives Q4 2019 to Q4 2021 total net flows by capability (US$bn) NET FLOWS BY CAPABILITY (12.2) (6.7) (8.2) (2.9) (1.1) (3.3) (2.5) (5.2) (5.2)

27 Note: Outperformance is measured based on composite performance gross of fees vs primary benchmark, except where a strategy has no benchmark index or corresponding composite in which case the most relevant metric is used: (1) composite gross of fees vs zero for absolute retu rn strategies, (2) fund net of fees vs primary index or (3) fund net of fees vs Morningstar peer group average or median. Non - discretionary and separately managed account assets are included with a corresponding composite where applicable. Cash management vehicles, ETF - enhanced beta strategies, Managed CDOs, Private Equity funds and custom non - discretionary account s with no corresponding composite are excluded from the analysis. Excluded assets represent 5% of AUM across all time periods. Capabilities defined by Janus Henderson. INVESTMENT PERFORMANCE % of AUM outperforming benchmark Capability 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr Equities 55% 54% 69% 77% 56% 56% 55% 78% 64% 56% 60% 84% 39% 37% 68% 81% Fixed Income 94% 97% 89% 98% 98% 96% 97% 98% 98% 96% 96% 99% 91% 96% 96% 98% Multi-Asset 98% 97% 94% 96% 98% 97% 97% 96% 99% 97% 97% 97% 99% 96% 96% 97% Quantitative Equities 48% 4% 11% 72% 23% 23% 2% 71% 41% 2% 2% 32% 8% 58% 53% 21% Alternatives 98% 97% 100% 100% 98% 97% 100% 100% 94% 97% 100% 100% 91% 100% 100% 100% Total 67% 62% 70% 83% 66% 66% 63% 83% 72% 64% 67% 86% 54% 58% 76% 84% Q1 2021 Q2 2021 Q3 2021 Q4 2021

28 INVESTMENT PERFORMANCE Note: Includes Janus Investment Fund, Janus Aspen Series and Clayton Street Trust (US Trusts), Janus Henderson Capital Funds (Du blin based), Dublin and UK OEIC and Investment Trusts, Luxembourg SICAVs and Australian Managed Investment Schemes. The top two Morningstar quartiles represent funds in the top half of their category based on total return. For the 1 - , 3 - , 5 - a nd 10 - year periods ending 31 December 2021, 43%, 57%, 55% and 64% of the 193, 184, 179 and 151 total mutual funds, respectively, were in the top 2 Morning star quartiles. Analysis based on ‘primary’ share class (Class I Shares, Institutional Shares or share class with longest history for US Trusts ; Class A Shares or share class with longest history for Dublin based; primary share class as defined by Morningstar for other funds). Performance may vary b y s hare class. Rankings may be based, in part, on the performance of a predecessor fund or share class and are calculated by Morningstar using a methodol ogy that differs from that used by Janus Henderson. Methodology differences may have a material effect on the return and therefore the ranking. When an exp ense waiver is in effect, it may have a material effect on the total return, and therefore the ranking for the period. ETFs and funds not ranked by Morningstar are excluded from the analysis. Capabilities defined by Janus Henderson. © 2021 Morn in gstar, Inc. All Rights Reserved. % of mutual fund AUM in top 2 Morningstar quartiles Capability 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr 1yr 3yr 5yr 10yr Equities 35% 60% 64% 79% 32% 59% 44% 71% 47% 47% 49% 68% 54% 51% 52% 86% Fixed Income 69% 79% 73% 70% 57% 80% 75% 71% 84% 77% 73% 69% 64% 81% 75% 70% Multi-Asset 19% 91% 92% 96% 19% 92% 91% 93% 20% 92% 92% 94% 95% 93% 93% 94% Quantitative Equities 32% 32% 4% 0% 41% 47% 7% 0% 11% 11% 11% 0% 0% 11% 13% 0% Alternatives 30% 76% 30% 98% 27% 76% 27% 98% 27% 70% 74% 98% 50% 34% 100% 100% Total 37% 67% 68% 81% 33% 67% 55% 75% 47% 59% 60% 73% 62% 61% 64% 86% Q1 2021 Q2 2021 Q3 2021 Q4 2021

29 INVESTMENT PERFORMANCE % of mutual fund AUM in top 2 Morningstar quartiles (continued) Group 10 21 17 24 44 42 47 44 42 41 45 44 57 57 48 59 27 12 29 38 24 26 13 17 26 14 14 19 24 18 25 26 37 33 47 62 67 67 59 61 68 55 60 64 81 75 73 86 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Equities 8 22 19 8 27 26 32 30 32 31 31 29 53 54 37 52 27 10 28 46 32 33 15 21 32 14 17 23 27 18 31 34 35 32 47 54 60 59 47 51 64 44 49 52 79 71 68 86 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 2 nd quartile 1 st quartile 1 - year 3 - year 5 - year 10 - year 1 - year 3 - year 5 - year 10 - year Note: Full performance disclosures detailed on slide 28. Numbers may not cast due to rounding.

30 INVESTMENT PERFORMANCE % of mutual fund AUM in top 2 Morningstar quartiles (continued) 2 nd quartile 1 st quartile Fixed Income Multi - Asset 27 30 25 21 69 71 70 61 38 40 56 55 31 33 48 46 43 27 59 43 11 9 7 19 35 35 17 21 39 38 21 23 69 57 84 64 79 80 77 81 73 75 73 75 70 71 69 70 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 1 15 4 92 90 91 92 92 91 91 91 92 92 93 93 94 18 4 16 4 1 1 1 1 1 1 1 1 4 1 1 1 19 19 20 95 91 92 92 93 92 91 92 93 96 93 94 94 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 1 - year 3 - year 5 - year 10 - year 1 - year 3 - year 5 - year 10 - year Note: Full performance disclosures detailed on slide 28. Numbers may not cast due to rounding.

31 7 11 4 7 11 4 7 11 11 32 34 28 40 11 2 32 41 11 0 32 47 11 11 4 7 11 13 0 0 0 0 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 19 0 14 2 74 20 24 8 24 22 65 64 67 50 66 71 12 26 13 48 2 56 46 26 6 6 9 36 31 48 32 29 30 27 27 50 76 76 70 34 30 27 74 100 98 98 98 100 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Q1 2021 Q2 2021 Q3 2021 Q4 2021 INVESTMENT PERFORMANCE % of mutual fund AUM in top 2 Morningstar quartiles (continued) Quantitative Equities Alternatives 2 nd quartile 1 st quartile 1 - year 3 - year 5 - year 10 - year 1 - year 3 - year 5 - year 10 - year Note: Full performance disclosures detailed on slide 28. Numbers may not cast due to rounding.

32 US GAAP: STATEMENT OF INCOME (US$m, except per share data or as noted) 31 Dec 21 30 Sep 21 31 Dec 20 31 Dec 21 31 Dec 20 Revenue Management fees 565.9 564.5 489.1 2,189.4 1,794.1 Performance fees 7.7 0.6 59.3 102.7 98.1 Shareowner servicing fees 68.3 67.6 57.9 260.7 209.2 Other revenue 55.3 54.7 50.9 214.2 197.2 Total revenue 697.2 687.4 657.2 2,767.0 2,298.6 Operating expenses Employee compensation and benefits 160.1 166.2 162.3 693.3 618.6 Long-term incentive plans 42.7 35.0 44.7 181.0 170.1 Distribution expenses 147.3 142.1 128.7 551.6 464.4 Investment administration 12.9 13.0 12.6 51.6 50.0 Marketing 11.3 7.5 3.9 31.7 19.6 General, administrative and occupancy 77.6 65.5 66.4 271.8 255.2 Impairment of goodwill and intangible assets 77.5 – – 121.9 513.7 Depreciation and amortisation 10.2 9.8 11.6 40.7 49.2 Total operating expenses 539.6 439.1 430.2 1,943.6 2,140.8 Operating income 157.6 248.3 227.0 823.4 157.8 Interest expense (3.2) (3.2) (3.2) (12.8) (12.9) Investment gains (losses), net (7.3) 4.7 32.2 0.8 57.5 Other non-operating income (expense), net 8.0 3.6 (0.2) 8.8 39.7 Income before taxes 155.1 253.4 255.8 820.2 242.1 Income tax provision (29.6) (53.3) (57.4) (205.7) (59.5) Net income 125.5 200.1 198.4 614.5 182.6 Net loss (income) attributable to noncontrolling interests 7.0 (3.3) (11.6) 7.6 (21.0) Net income attributable to JHG 132.5 196.8 186.8 622.1 161.6 Less: allocation of earnings to participating stock-based (3.6) (5.4) (5.5) (17.7) (4.7) Net income attributable to JHG common shareholders 128.9 191.4 181.3 604.4 156.9 Diluted weighted-average shares outstanding (m) 166.2 167.8 177.0 168.5 179.9 Diluted earnings per share (in US$) 0.78 1.14 1.02 3.59 0.87 Year ended 3 months ended

33 ALTERNATIVE PERFORMANCE MEASURES Reconciliation of adjusted financial measures Note: Reconciliation to be used in conjunction with slide 34. Footnotes included on slide 35. (US$m, except per share data) 31 Dec 21 30 Sep 21 31 Dec 20 31 Dec 21 31 Dec 20 Reconciliation of revenue to adjusted revenue Revenue 697.2 687.4 657.2 2,767.0 2,298.6 Management fees 1 (56.5) (53.0) (51.6) (205.9) (183.8) Shareowner servicing fees 1 (56.2) (55.4) (47.4) (214.7) (170.3) Other revenue 1 (34.6) (33.7) (29.7) (131.0) (110.3) Adjusted revenue 549.9 545.3 528.5 2,215.4 1,834.2 Reconciliation of operating expenses to adjusted operating expenses Operating expenses 539.6 439.1 430.2 1,943.6 2,140.8 Employee compensation and benefits 2 – – (0.1) – (2.3) Long-term incentive plans 2 0.1 0.1 0.1 0.4 0.5 Distribution expenses 1 (147.3) (142.1) (128.7) (551.6) (464.4) General, administrative and occupancy 2 (2.6) (2.9) (2.8) (10.8) (11.0) Impairment of goodwill and intangible assets 3 (77.5) – – (121.9) (513.7) Depreciation and amortisation 3 (2.1) (1.9) (1.9) (7.8) (12.4) Adjusted operating expenses 310.2 292.3 296.8 1,251.9 1,137.5 3 months ended Year ended

34 ALTERNATIVE PERFORMANCE MEASURES Reconciliation of adjusted financial measures (continued) (US$m, except per share data) 31 Dec 21 30 Sep 21 31 Dec 20 31 Dec 21 31 Dec 20 Reconciliation of net income attributable to JHG to adjusted net income attributable to JHG Net income attributable to JHG 132.5 196.8 186.8 622.1 161.6 Employee compensation and benefits 2 – – 0.1 – 2.3 Long-term incentive plans 2 (0.1) (0.1) (0.1) (0.4) (0.5) General, administrative and occupancy 2 2.6 2.9 2.8 10.8 11.0 Impairment of goodwill and intangible assets 3 77.5 – – 121.9 513.7 Depreciation and amortisation 3 2.1 1.9 1.9 7.8 12.4 Interest expense 4 – – – – 0.1 Investment gains (losses), net 4 – – (1.4) 0.2 (1.4) Other non-operating expense, net 4 (9.1) (1.6) (1.7) (14.2) (28.7) Income tax benefit (provision) 5 (25.4) (0.4) 0.6 (6.6) (112.6) Adjusted net income attributable to JHG 180.1 199.5 189.0 741.6 557.9 Diluted earnings per share (in US$) 0.78 1.14 1.02 3.59 0.87 Adjusted diluted earnings per share (in US$) 1.05 1.16 1.04 4.28 3.01 3 months ended Year ended Note: Reconciliation to be used in conjunction with slide 33. Footnotes included on slide 35.

35 ALTERNATIVE PERFORMANCE MEASURES Footnotes to reconciliation of adjusted financial measures 1 JHG contracts with third - party intermediaries to distribute and service certain of its investment products .. Fees for distribution and servicing related activities are either provided for separately in an investment product’s prospectus or are part of the management fee .. Under both arrangements, the fees are collected by JHG and passed through to third - party intermediaries who are responsible for performing the applicable services .. The majority of distribution and servicing fees collected by JHG are passed through to third - party intermediaries .. JHG management believes that the deduction of distribution and service fees from revenue in the computation of adjusted revenue reflects the pass - through nature of these revenues .. In certain arrangements, JHG performs the distribution and servicing activities and retains the applicable fees .. Revenues for distribution and servicing activities performed by JHG are not deducted from GAAP revenue .. 2 Adjustments primarily represent rent expense for subleased office space .. In addition, the adjustments for the three months ended 30 September 2021 and the year ended 31 December 2021 include a one - time charge related to the employee benefits trust .. JHG management believes these costs are not representative of the ongoing operations of the Group .. 3 Investment management contracts have been identified as a separately identifiable intangible asset arising on the acquisition of subsidiaries and businesses .. Such contracts are recognised at the net present value of the expected future cash flows arising from the contracts at the date of acquisition .. For segregated mandate contracts, the intangible asset is amortised on a straight - line basis over the expected life of the contracts .. Adjustments also include impairment charges of our goodwill and certain mutual fund investment management agreements, client relationships and trademarks .. JHG management believes these non - cash and acquisition - related costs are not representative of the ongoing operations of the Group .. 4 Adjustments primarily represent contingent consideration adjustments associated with prior acquisitions .. JHG management believes these costs are not representative of the ongoing operations of the Group .. 5 The tax impact of the adjustments is calculated based on the applicable US or foreign statutory tax rate as it relates to each adjustment .. Certain adjustments are either not taxable or not tax - deductible ..

36 CAPITAL MANAGEMENT Note: JHG purchases shares on market for the annual share grants associated with variable compensation, which is not included i n the above share repurchases. Numbers may not cast due to rounding. 1 Total shares outstanding reflect amounts disclosed on Forms 10 - Q or 10 - K for each respective quarter. 2 Cumulative decrease from commencement of buyback programme in Q3 2018. Continued commitment to return of capital Dividend paid / share (US$) 0.36 0.36 0.36 0.36 0.36 0.38 0.38 0.38 Shares repurchased (m) 2.1 1.1 2.4 1.0 8.1 0.0 1.8 1.5 Total shares outstanding 1 (m) 184.9 183.9 181.4 180.4 172.3 172.3 170.6 169.0 Cumulative decrease in shares 2 7.7% 8.3% 9.5% 10.0% 14.0% 14.0% 14.9% 15.6% Q1 2020 to Q4 2021 quarterly capital return (US$m) 66.2 66.1 65.8 64.8 61.7 64.8 64.5 31.2 22.0 50.2 27.4 230.2 75.0 66.9 97.4 88.1 116.0 92.2 291.9 65.0 139.8 131.4 Q1 2020 Q2 2020 Q3 2020 Q4 2020 Q1 2021 Q2 2021 Q3 2021 Q4 2021 Dividends Share repurchases

37 PERFORMANCE FEES Note: Performance fees include prior quarter accrual true - ups. 1 AUM data present US mutual fund AUM subject to performance fees as at 31 December 2021. Janus Investment Funds and Janus Aspe n S eries Portfolios are counted as distinct and separate funds. Q4 2021 (US$m) Q3 2021 (US$m) Q4 2020 (US$m) AUM generating Q4 2021 pfees (US$bn) # of funds generating Q4 2021 pfees Frequency Timing SICAVs 0.1 1.0 5.4 – – 17 annually; 3 quarterly 17 at June; 3 on quarters UK OEICs and unit trusts – – 0.5 – – annually various Offshore absolute return and other funds 11.0 1.1 6.9 0.9 4 quarterly / annually various Segregated mandates 2.7 – 48.6 9.3 16 quarterly / annually various Investment trusts 1.6 – – 0.2 1 annually various US mutual funds 1 (7.7) (1.5) (2.1) 66.1 15 monthly monthly Total 7.7 0.6 59.3 76.5 36

38 US MUTUAL FUNDS WITH PERFORMANCE FEES Note: Numbers may not cast due to rounding. 1 The funds listed have a performance - based investment advisory fee that adjusts up or down based on performance relative to a ben chmark over 36 - month rolling periods. Please see the funds’ Statements of Additional Information for more details and benchmark information. 2 Adjustment of ± 15 bps assumes constant assets and could be higher or lower depending on asset fluctuations. 3 Until 1 August 2022, the Fund’s performance during the portion of the performance measurement period prior to 1 August 2019 w il l be compared to the Fund's former benchmark, the Russell 3000 ® Value Index. Mutual funds with performance fees¹ AUM 31 Dec 21 (US$m) Benchmark Base fee Performance fee 2 Performance cap/(floor) vs benchmark Q4 2021 P&L impact (US$’000) Forty Fund and Portfolio 23,716 Russell 1000 ® Growth Index 0.64% ± 15 bps ± 8.50% (1,815) Research Fund and Portfolio 22,184 Russell 1000 ® Growth Index 0.64% ± 15 bps ± 5.00% (6,457) Contrarian Fund 5,303 S&P 500 ® Index 0.64% ± 15 bps ± 7.00% 1,283 Global Research Fund and Portfolio 4,499 MSCI World Index SM 0.60% ± 15 bps ± 6.00% 725 Small Cap Value Fund 3,812 Russell 2000 ® Value Index 0.72% ± 15 bps ± 5.50% (1,287) Mid Cap Value Fund and Portfolio 2,915 Russell Midcap ® Value Index 0.64% ± 15 bps ± 4.00% (1,132) Overseas Fund and Portfolio 2,592 MSCI All Country World ex - U.S. Index SM 0.64% ± 15 bps ± 7.00% 772 Global Real Estate Fund 925 FTSE EPRA / NAREIT Global Index 0.75% ± 15 bps ± 4.00% 219 Small - Mid Cap Value Fund 3 109 Russell 2500 TM Value Index 0.70% ± 15 bps ± 5.00% (30) Asia Equity Fund 22 MSCI All Country Asia ex - Japan Index SM 0.92% ± 15 bps ± 7.00% (11) Total 66,077 (7,733)

39 LONG - TERM INCENTIVE COMPENSATION Note: Annual grants generally vest over three and four years. Assumed no forfeitures in future periods. Assumed no change in fut ure values related to market or currency, which would impact expense related to cash - based awards (MFSAs, DIP and DEP funds) and social security expense upon ve sting. 1 Estimated 2022 annual grant based on amounts expected to be granted associated with the annual award process. Actual awards a re expected to be between US$210m and US$220m. 2 Includes retention and recruiting awards; other subsidiary grants and social security expense. Social security expense is est ima ted based on amount of existing awards expected to vest in that year. Estimated future long - term incentive compensation amortization (US$ m) Amount remaining to expense 2022 2023 2024 2025 2026 2019 annual grant 3 3 – – – – 2020 annual grant 20 18 2 – – – 2021 annual grant 68 46 19 3 – – Estimated 2022 annual grant 1 215 110 71 30 4 – Other 2 60 19 17 12 9 3 Total long - term incentive compensation 366 196 109 45 13 3

40 CONTACTS Investor enquiries Melanie Horton Co - Head Investor Relations (Non - US) +44 (0)20 7818 2905 [email protected] Jim Kurtz Co - Head Investor Relations (US) +1 303 336 4529 [email protected] Investor Relations [email protected] Media enquiries Stephen Sobey +44 (0)20 7818 2523 [email protected] Sarah Johnson +1 720 364 0708 [email protected] United Kingdom: Edelman Smithfield Latika Shah +44 (0)7950 671 948 [email protected] Andrew Wilde +44 (0)7786 022 022 [email protected] Asia Pacific: Honner Craig Morris +61 2 8248 3757 [email protected]

201 Bishopsgate London EC2M 3AE United Kingdom www.janushenderson.com Contact us Past performance is no guarantee of future results. Investing involves risk, including the possible loss of principal and flu ctu ation of value. Forward - looking information This presentation includes statements concerning potential future events involving Janus Henderson Group plc that could diffe r m aterially from the events that actually occur. The differences could be caused by a number of factors, including those factors identified in Jan us Henderson Group’s Annual Report on Form 10 - K for the fiscal year ended 31 December 2020 and the Company’s other filings and furnishings with the S ecurities and Exchange Commission (Commission file no. 001 - 38103), including those that appear under headings such as ‘Risk Factors’ and ‘Mana gement’s Discussion and Analysis of Financial Condition and Results of Operations’. Many of these factors are beyond the control of th e C ompany and its management. Any forward - looking statements contained in this presentation are as of the date on which such statements were made. The Company assumes no duty to update them, even if experience, unexpected events, or future changes make it clear that any projected res ult s expressed or implied therein will not be realised .. Annualised, pro forma, projected and estimated numbers are used for illustrative purposes only, are not forecasts and may not reflect actual results. No public offer The information, statements and opinions contained in this presentation do not constitute a public offer under any applicable le gislation or an offer to sell or solicitation of any offer to buy any securities or financial instruments or any advice or recommendation with respect to such securities or other financial instruments. Not all products or services are available in all jurisdictions. Various account minimums or other eligibility qualifications ap ply depending on the investment strategy, vehicle or investor jurisdiction. Mutual funds in the US distributed by Janus Henderson Distributors US LLC .. Please consider the charges, risks, expenses and investment objectives carefully before investing. For a US fund prospectus or, if available, a summary prospectus containing this and other information, please contact your investment professional or call 800.668.0434. Read it carefully before you invest or send money. Janus Henderson and Intech are trademarks of Janus Henderson Group plc or one of its subsidiaries. © Janus Henderson Group plc.


Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, $1.50 Per Share Par Value	JHG	New York Stock Exchange


Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
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☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))


Exhibit Number		Description
99.1		Janus Henderson Group plc press release reporting its financial results for the fourth quarter and full-year 2021.
99.2		Janus Henderson Group plc fourth quarter and full-year 2021 earnings presentation.
104		Cover Page Interactive Data File - The cover page interactive data file does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document.


	Janus Henderson Group plc

Date: February 3, 2022	By:	/s/ Roger Thompson
		Roger Thompson
		Chief Financial Officer