8-K

SIMMONS FIRST NATIONAL CORPORATION

/s/ C. Daniel Hobbs

Date: October 16, 2025

C. Daniel Hobbs, Executive Vice President and

Chief Financial Officer

Exhibit 99.1

LOGO

October 16, 2025

Simmons First National Corporation Reports Third Quarter 2025 Results

George Makris, Jr., Simmons’ Chairman and CEO, commented on third quarter 2025 results:

The third quarter was transformative for Simmons. With overwhelming investor support we successfully raised $327 million of equity capital to reposition our balance sheet and unlock our future earnings stream. We effectively addressed a negative arbitrage between long-term bond yields and shorter-term funding costs which freed up capital for future growth. While the one-time loss on the sale of the bonds was significant, the financial strength of our company coupled with the positive sentiment from investors allowed us that opportunity.

Although the benefit of the repositioning was only partially realized in the quarter based on the timing of the transactions, our results demonstrated the exceptional improvement in our profitability, and the results from the month of September are very encouraging for our future performance.

I believe we are now well positioned to deliver stronger organic growth throughout our franchise which includes some of the most dynamic markets in the country. Our team is prepared, and I am optimistic about Simmons’ future.

Simmons First National Corporation (NASDAQ: SFNC) (Simmons or Company) today reported a net loss of $562.8 million for the third quarter of 2025, compared to net income of $54.8 million in the second quarter of 2025 and $24.7 million in the third quarter of 2024. Diluted earnings per share were $(4.00) for the third quarter of 2025, compared to $0.43 in the second quarter of 2025 and $0.20 for the third quarter of 2024. Adjusted earnings¹ for the third quarter of 2025 were $64.9 million, compared to $56.1 million in the second quarter of 2025 and $46.0 million in the third quarter of 2024. Adjusted diluted earnings per share¹ for the third quarter of 2025 were $0.46, compared to $0.44 in the second quarter of 2025 and $0.37 in the third quarter of 2024.

As previously disclosed, on July 22, 2025, the Company announced the pricing of its public offering of the Company’s Class A common stock that generated net proceeds of approximately $327 million. Proceeds from the offering were subsequently utilized to support a balance sheet repositioning that included the sale of approximately $2.4 billion (fair value) of low-yielding investment securities at an after-tax loss of approximately $626 million. Proceeds from the sale of the investment securities were primarily used to deleverage the balance sheet through the pay-down of higher rate, non-relationship wholesale and public fund deposits, as well as higher rate other borrowings primarily consisting of FHLB advances. The pay-down of higher rate funding was completed throughout the third quarter of 2025, and thus the benefits (including interest expense savings) are only partially reflected in the results for the quarter.

The table below summarizes the impact of the loss on the sale of securities, as well as other certain items, consisting primarily of branch right sizing costs, early retirement program costs and loss on early extinguishment of debt. These items are also described in further detail in the “Reconciliation of Non-GAAP Financial Measures” tables contained in this press release.

Impact of Certain Items on Earnings and Diluted Earnings Per Share (EPS)


$ in millions, except per share data	3Q25			2Q25			3Q24
Net income (loss)	$	(562.8	)	$	54.8		$	24.7
Branch right sizing costs, net		2.0			0.2			0.4
Early retirement program costs		0.3			1.6			—
Loss on early extinguishment of debt		0.6			—			—
Loss on sale of securities		801.5			—			28.4

Total pre-tax impact		804.4			1.8			28.8
Tax effect		(176.7	)		(0.5	)		(7.5	)

Total impact on earnings		627.7			1.3			21.3

Adjusted earnings^1,3	$	64.9		$	56.1		$	46.0


Diluted EPS	$	(4.00	)	$	0.43	$	0.20
Branch right sizing costs, net		0.01			—		—
Early retirement program costs		—			0.01		—
Loss on early extinguishment of debt		—			—		—
Loss on sale of securities		5.70			—		0.23

Total pre-tax impact		5.71			0.01		0.23
Tax effect		(1.25	)		—		(0.06	)

Total impact on earnings		4.46			0.01		0.17

Adjusted Diluted EPS¹	$	0.46		$	0.44	$	0.37

The Financial Highlights table below summarizes key financial metrics for the third quarter of 2025, the second quarter of 2025 and the third quarter of 2024.


FINANCIAL HIGHLIGHTS	3Q25			2Q25			3Q24			3Q25 Highlights
BALANCE SHEET (in millions)										Comparisons reflect 3Q25 vs 2Q25 unless otherwise noted • Net loss of $562.8 million and diluted EPS of $(4.00) • Adjusted net income¹ of $64.9 million and adjusted diluted EPS¹ of $0.46 • Total revenue of $(569.5) million and PPNR¹ of $(711.6) million • Adjusted total revenue¹ of $232.5 million and adjusted PPNR¹ of $92.8 million • Net interest income up $14.8 million, or 9 percent • Net interest margin up 44 basis points to 3.50%; the 6^th consecutive quarterly increase in net interest margin • Pricing discipline led to 5 basis point increase in loan yields • Cost of deposits down 11 bps; reduction in higher rate funding only partially reflected in 3Q25 results • NCO ratio of 25 bps in 3Q24; provision for credit losses on loans exceeded net charge-offs by $4.5 million • ACL ratio up 2 bps to 1.50%
Total loans	$	17,189		$	17,111		$	17,336
Total investment securities		3,319			5,997			6,350
Total deposits		19,838			21,825			21,935
Total assets		24,208			26,694			27,269
Total shareholders’ equity		3,354			3,549			3,529
PERFORMANCE MEASURES (in millions)
Total revenue	$	(569.5	)	$	214.2		$	174.8
Adjusted total revenue¹		232.5			214.2			203.2
Pre-provision net revenue¹ (PPNR)		(711.6	)		75.6			37.6
Adjusted pre-provision net revenue¹		92.8			77.3			66.4
Provision for credit losses		12.0			11.9			12.1
PER SHARE DATA
Diluted earnings	$	(4.00	)	$	0.43		$	0.20
Adjusted diluted earnings¹		0.46			0.44			0.37
Cash dividend declared		0.2125			0.2125			0.21
ASSET QUALITY
Net charge-off ratio (NCO ratio)		0.25	%		0.25	%		0.22	%
Nonperforming loan ratio		0.90			0.92			0.59
Nonperforming assets to total assets		0.66			0.62			0.38
Allowance for credit losses to loans (ACL)		1.50			1.48			1.35
Nonperforming loan coverage ratio		168			161			229
CAPITAL RATIOS
Equity to assets (EA ratio)		13.85	%		13.30	%		12.94	%
Tangible common equity (TCE) ratio¹		8.53			8.46			8.15
Common equity tier 1 (CET1) ratio		11.54			12.36			12.06
Total risk-based capital ratio		15.07			14.42			14.25
OTHER DATA
Net interest margin (FTE)		3.50	%		3.06	%		2.74	%
Loan yield (FTE)		6.31			6.26			6.44
Cost of deposits		2.25			2.36			2.79
Full-time equivalent employees		2,883			2,947			2,972
Number of financial centers		223			223			234

Net Interest Income

Net interest income for the third quarter of 2025 totaled $186.7 million, up $14.8 million, or 9 percent, compared to $171.8 million in the second quarter of 2025 and up $28.9 million, or 18 percent, from $157.7 million in the third quarter of 2024. Interest income totaled $313.4 million for the third quarter of 2025, compared to $315.0 million in the second quarter of 2025 and $334.3 million in the third quarter of 2024. The decrease in interest income on a linked quarter basis was primarily due to a decline in the level of interest income derived from investment securities resulting from the balance sheet repositioning undertaken in the third quarter of 2025 that included the sale of lower-

yielding investment securities, that was offset by increases in interest income from loans and other earning assets. Interest expense totaled $126.8 million for the third quarter of 2025, compared to $143.2 million in the second quarter of 2025 and $176.6 million in the third quarter of 2024. The decrease in interest expense on a linked quarter basis was primarily due to a reduction of higher rate, non-relationship wholesale and public fund deposits as part of the balance sheet repositioning.


Select Yield/Rates	3Q25			2Q25			1Q25			4Q24			3Q24
Loan yield (FTE)²		6.31	%		6.26	%		6.20	%		6.32	%		6.44	%
Investment securities yield (FTE)²		4.01			3.48			3.48			3.54			3.63
Cost of interest bearing deposits		2.86			2.97			3.05			3.28			3.52
Cost of deposits		2.25			2.36			2.44			2.60			2.79
Net interest spread (FTE)²		2.86			2.41			2.30			2.15			1.95
Net interest margin (FTE)²		3.50			3.06			2.95			2.87			2.74

Noninterest Income

Noninterest income for the third quarter of 2025 was $(756.2) million, compared to $42.4 million in the second quarter of 2025 and $17.1 million in the third quarter of 2024. Included in third quarter 2025 results was a $801.5 million pre-tax loss on the sale of low-yielding securities that were sold in connection with the previously mentioned balance sheet repositioning and $0.6 million loss on the early extinguishment of debt. The third quarter of 2024 included a $28.4 million pre-tax loss on the sale of low-yielding securities. Excluding these items (which are described in the “Reconciliation of Non-GAAP Financial Measures” tables below), adjusted noninterest income¹ was $45.9 million for the third quarter of 2025, $42.4 million in the second quarter of 2025 and $45.5 million in the third quarter of 2024. The increase in adjusted noninterest income on a linked quarter basis was broad based, led by an increase in mortgage lending income and a Small Business Investment Company (SBIC) negative valuation adjustment in the second quarter of 2025, which is included in other income in the table below.


Noninterest Income $ in millions	3Q25			2Q25		1Q25		4Q24		3Q24
Service charges on deposit accounts	$	13.0		$	12.6	$	12.6	$	13.0	$	12.7
Wealth management fees		10.0			9.5		9.6		9.7		9.1
Debit and credit card fees		8.5			8.6		8.4		8.3		8.1
Mortgage lending income		2.3			1.7		2.0		1.8		2.0
Other service charges and fees		1.5			1.3		1.3		1.4		1.5
Bank owned life insurance		3.9			3.9		4.1		3.8		3.8
Gain (loss) on sale of securities		(801.5	)		—		—		—		(28.4	)
Other income		6.1			4.8		8.0		5.6		8.3

Total noninterest income	$	(756.2	)	$	42.4	$	46.2	$	43.6	$	17.1

Adjusted noninterest income¹	$	45.9		$	42.4	$	46.2	$	43.6	$	45.5

Noninterest Expense

Noninterest expense for the third quarter of 2025 was $142.0 million, compared to $138.6 million in the second quarter of 2025 and $137.2 million in the third quarter of 2024. Included in noninterest expense are certain items consisting of branch right sizing costs, early retirement program costs and termination of vendor and software services. Collectively, these items totaled $2.3 million in the third quarter of 2025, $1.8 million in the second quarter of 2025 and $0.4 million in the third quarter of 2024. Excluding these items (which are described in the “Reconciliation of Non-GAAP Financial Measures” tables below), adjusted noninterest expense¹ was $139.7 million for the third quarter of 2025, and $136.8 million in both the second quarter of 2025 and third quarter of 2024. The increase in adjusted noninterest expense on a linked quarter basis primarily reflected salary and employee benefits accrual adjustments given the Company’s financial performance through the third quarter of 2025 and a $1.6 million fraud recovery in the third quarter of 2025.


Noninterest Expense $ in millions	3Q25			2Q25			1Q25			4Q24			3Q24
Salaries and employee benefits	$	76.2		$	73.9		$	74.8		$	71.6		$	69.2
Occupancy expense, net		12.1			11.8			12.7			11.9			12.2
Furniture and equipment		5.3			5.5			5.5			5.7			5.6
Deposit insurance		5.2			4.9			5.4			5.6			5.6
Other real estate and foreclosure expense		0.2			0.2			0.2			0.3			0.1
Other operating expenses		43.0			42.3			46.1			46.1			44.5

Total noninterest expense	$	142.0		$	138.6		$	144.6		$	141.1		$	137.2

Adjusted salaries and employee benefits¹	$	75.9		$	72.3		$	74.8		$	71.4		$	69.2
Adjusted other operating expenses¹		41.5			42.5			45.9			44.7			44.4
Adjusted noninterest expense¹		139.7			136.8			143.6			139.3			136.8
Efficiency ratio		(25.11	)%		62.82	%		66.94	%		65.66	%		75.70	%
Adjusted efficiency ratio¹		57.72			60.52			64.75			62.89			63.38
Full-time equivalent employees		2,883			2,947			2,949			2,946			2,972
Number of financial centers		223			223			222			222			234

Loans and Unfunded Loan Commitments

Total loans at the end of the third quarter of 2025 were $17.2 billion, up 2 percent on a linked quarter annualized basis. The increase in total loans was driven by increases in mortgage warehouse, real estate – construction and agricultural, offset in part by declines in real estate – commercial and commercial portfolios. Unfunded loan commitments at the end of the third quarter of 2025 were $4.0 billion, compared to $3.9 billion at the end of the second quarter of 2025. This marked the fourth consecutive quarterly increase in unfunded loan commitments. The commercial loan pipeline totaled $1.6 billion at the end of the third quarter of 2025, and ready to close commercial loans totaled $490 million with a weighted average rate of 7.19 percent.


Loans and Unfunded Loan Commitments $ in millions	3Q25		2Q25		1Q25		4Q24		3Q24
Total loans	$	17,189	$	17,111	$	17,094	$	17,006	$	17,336
Unfunded loan commitments		3,955		3,947		3,888		3,739		3,681

Deposits and Other Borrowings

Total deposits at the end of the third quarter of 2025 were $19.8 billion, compared to $21.8 billion at the end of the second quarter of 2025 and $21.9 billion at the end of the third quarter of 2024. The decrease in total deposits reflects a reduction of higher rate, non-relationship wholesale and public fund deposits as part of the balance sheet repositioning previously mentioned. At the same time, the overall mix of deposits improved with noninterest bearing deposits representing 22.1 percent of total deposits at the end of the third quarter of 2025, compared to 20.5 percent at the end of the second quarter of 2025. Interest bearing transaction accounts (excluding interest bearing public funds) represent 42.8 percent of total deposits at the end of the third quarter of 2025, compared to 39.0 percent at the end of the second quarter of 2025.

Other borrowings at the end of the third quarter of 2025 were $18.8 million, compared to $634.3 million at the end of the second quarter of 2025 and $1.0 billion at the end of the third quarter of 2024. The decrease in other borrowings on a linked quarter basis and year-over-year basis reflected the pay down of higher cost wholesale funding, primarily FHLB advances, as part of the balance sheet repositioning.


Deposits $ in millions	3Q25			2Q25			1Q25			4Q24			3Q24
Noninterest bearing deposits	$	4,377		$	4,468		$	4,455		$	4,461		$	4,522
Interest bearing transaction accounts		10,289			10,532			10,621			10,331			10,038
Time deposits		3,331			3,588			3,695			3,796			4,014
Brokered deposits		1,841			3,237			2,914			3,298			3,361

Total deposits	$	19,838		$	21,825		$	21,684		$	21,886		$	21,935

Noninterest bearing deposits to total deposits		22	%		20	%		21	%		20	%		21	%
Total loans to total deposits		87			78			79			78			79

Asset Quality

Total nonperforming loans at the end of the third quarter of 2025 totaled $153.9 million, compared to $157.2 million at the end of the second quarter of 2025 and $101.7 million at the end of the third quarter of 2024. The decrease in nonperforming loans on a linked quarter basis primarily reflected declines in commercial and real estate – single family loan portfolios, offset in part by an increase in the real estate – commercial portfolio. The increase in

nonperforming loans on a year-over-year basis was primarily due to two specific credit relationships that were placed on nonaccrual at the end of first quarter of 2025. The nonperforming loan coverage ratio ended the third quarter of 2025 at 168 percent, compared to 161 percent at the end of the second quarter of 2025 and 229 percent at the end of the third quarter of 2024. Total nonperforming assets as a percentage of total assets were 66 basis points at the end of the third quarter of 2025, compared to 62 basis points at the end of the second quarter of 2025 and 38 basis points at the end of the third quarter of 2024.

Provision for credit losses on loans totaled $15.2 million for the third quarter of 2025, compared to $11.9 million in the second quarter of 2025 and $12.1 million in the third quarter of 2024. The allowance for credit losses on loans at the end of the third quarter of 2025 was $258.0 million, compared to $253.5 million at the end of the second quarter of 2025 and $233.2 million at the end of the third quarter of 2024. The allowance for credit losses on loans as a percentage of total loans was 1.50 percent at the end of the third quarter of 2025, compared to 1.48 percent at the end of the second quarter of 2025 and 1.35 percent at the end of the third quarter of 2024.

Net charge-offs as a percentage of average loans for the third quarter of 2025 were 25 basis points, unchanged from second quarter 2025 levels and up slightly from 22 basis points in the third quarter of 2024. Provision for credit losses on loans exceeded net charge-offs by $4.5 million in the third quarter of 2025, $1.4 million in the second quarter of 2025 and $2.8 million in the third quarter of 2024.


Asset Quality $ in millions	3Q25			2Q25			1Q25			4Q24			3Q24
Allowance for credit losses on loans to total loans		1.50	%		1.48	%		1.48	%		1.38	%		1.35	%
Allowance for credit losses on loans to nonperforming loans		168			161			165			212			229
Nonperforming loans to total loans		0.90			0.92			0.89			0.65			0.59
Net charge-off ratio (annualized)		0.25			0.25			0.23			0.27			0.22
Net charge-off ratio YTD (annualized)		0.24			0.24			0.23			0.22			0.20
Total nonperforming loans	$	153.9		$	157.2		$	152.3		$	110.7		$	101.7
Total other nonperforming assets		6.8			9.5			10.0			10.5			2.6

Total nonperforming assets	$	160.7		$	166.7		$	162.3		$	121.2		$	104.3

Reserve for unfunded commitments	$	25.6		$	25.6		$	25.6		$	25.6		$	25.6

Capital and Subordinated Debt

Total stockholders’ equity at the end of the third quarter was $3.4 billion, compared to $3.5 billion at the end of both the second quarter of 2025 and the third quarter of 2024. The decrease on a linked quarter basis and year-over-year basis was primarily due to a decline in undivided profits, reflecting the loss on sale of securities, offset in part by net proceeds of approximately $327 million from a common equity offering completed prior to commencement of the balance sheet repositioning. Book value per share at the end of the third quarter of 2025 was $23.18, compared to $28.17 at the end of the second quarter of 2025 and $28.11 at the end of the third quarter of 2024. Tangible book value per share¹ at the end of the third quarter of 2025 was $13.45, compared to $16.97 at the end of the second quarter of 2025 and $16.78 at the end of the third quarter of 2024. The decrease in book value per share and tangible book value per share was due to the loss on the sale of investment securities.

Total stockholders’ equity as a percentage of total assets at the end of the third quarter of 2025 was 13.9 percent, compared to 13.3 percent at the end of the second quarter of 2025 and 12.9 percent at the end of the third quarter of 2024. Tangible common equity as a percentage of tangible assets¹ was 8.5 percent at the end of both the third quarter of 2025 and second quarter of 2025, and 8.2 percent at the end of the third quarter of 2024. Each of the applicable regulatory capital ratios for Simmons and its principal subsidiary, Simmons Bank, continue to significantly exceed “well-capitalized” regulatory guidelines.

During the third quarter of 2025, the Company completed the offering and sale of $325 million in aggregate principal amount of its 6.25% Fixed-to-Floating Rate Subordinated Notes due 2035 (the “Notes”). The Notes were priced at par. The Company used the net proceeds from the offering, along with cash on hand, to repay in full the Company’s outstanding $330 million principal amount of its Fixed-to-Floating Rate Subordinated Notes due 2028, which was completed on October 1, 2025. Additionally, on July 31, 2025, the Company completed the redemption of the Company’s outstanding $37 million principal amount of its Fixed-to-Floating Rate Subordinated Notes due 2030.


Select Capital Ratios	3Q25			2Q25			1Q25			4Q24			3Q24
Stockholders’ equity to total assets		13.9	%		13.3	%		13.2	%		13.1	%		12.9	%
Tangible common equity to tangible assets¹		8.5			8.5			8.3			8.3			8.2
Common equity tier 1 (CET1) ratio		11.5			12.4			12.2			12.4			12.1
Tier 1 leverage ratio		9.6			10.0			9.8			9.7			9.6
Tier 1 risk-based capital ratio		11.5			12.4			12.2			12.4			12.1
Total risk-based capital ratio		15.1			14.4			14.6			14.6			14.3

Share Repurchase Program

During the third quarter of 2025, Simmons did not repurchase shares under its stock repurchase program that was authorized in January 2024 (2024 Program), which replaced its former repurchase program that was authorized in January 2022. Remaining authorization under the 2024 Program as of September 30, 2025, was approximately $175 million. The timing, pricing and amount of any repurchases under the 2024 Program will be determined by Simmons’ management at its discretion based on a variety of factors including, but not limited to, market conditions, trading volume and market price of Simmons’ common stock, Simmons’ capital needs, Simmons’ working capital and investment requirements, other corporate considerations, economic conditions, and legal requirements. The 2024 Program does not obligate Simmons to repurchase any common stock and may be modified, discontinued or suspended at any time without prior notice.

(1)

Non-GAAP measurement. See “Non-GAAP Financial Measures” and “Reconciliation of Non-GAAP Financial Measures” below

(2)

FTE – fully taxable equivalent basis using an effective tax rate of 26.135%

(3)

In this press release, “Adjusted Earnings” may also be referred to as “Adjusted Net Income”

Conference Call

Management will conduct a live conference call to review this information beginning at 7:30 a.m. Central Time on Friday, October 17, 2025. Interested persons can listen to this call by dialing toll-free 1-844-481-2779 (North America only) and asking for the Simmons First National Corporation conference call, conference ID 10203266. In addition, the call will be available live or in recorded version on Simmons’ website at simmonsbank.com for at least 60 days following the date of the call.

Simmons First National Corporation

Simmons First National Corporation (NASDAQ: SFNC) is a Mid-South based financial holding company that has paid cash dividends to its shareholders for 116 consecutive years. Its principal subsidiary, Simmons Bank, operates more than 220 branches in Arkansas, Kansas, Missouri, Oklahoma, Tennessee and Texas. Founded in 1903, Simmons Bank offers comprehensive financial solutions delivered with a client-centric approach. Recently, Simmons Bank was recognized by Newsweek as one of America’s Greatest Workplaces 2025 in Arkansas. In 2024, Simmons Bank was recognized by Newsweek as one of America’s Best Regional Banks 2025, by U.S. News & World Report as one of the 2024-2025 Best Companies to Work For in the South and by Forbes as one of America’s Best-In-State Banks 2024 in Tennessee and America’s Best-In-State Employers 2024 in Missouri. Additional information about Simmons Bank can be found on our website at simmonsbank.com, by following @Simmons_Bank on X (formerly Twitter) or by visiting our newsroom.

Non-GAAP Financial Measures

This press release contains financial information determined by methods other than in accordance with U.S. generally accepted accounting principles (GAAP). The Company’s management uses these non-GAAP financial measures in their analysis of the Company’s performance. These measures adjust GAAP performance measures to, among other things, include the tax benefit associated with revenue items that are tax-exempt, as well as exclude from net income (including on a per share diluted basis), pre-tax, pre-provision earnings, net charge-offs, income available to common shareholders, noninterest income, and noninterest expense certain income and expense items attributable to, for example, losses on sale of securities, net branch right-sizing initiatives, early retirement program, termination of vendor and software services and losses on early extinguishment of debt.

In addition, the Company also presents certain figures based on tangible common stockholders’ equity, tangible assets and tangible book value, which exclude goodwill and other intangible assets. The Company further presents certain figures that are exclusive of the impact of deposits and/or loans acquired through acquisitions, mortgage warehouse loans, and/or energy loans, or gains and/or losses on the sale of securities, or the aforementioned two specific credit relationships. The Company’s management believes that these non-GAAP financial measures are useful to investors because they, among other things, present the results of the Company’s ongoing operations without the effect of mergers or other items not central to the Company’s ongoing business, as well as normalize for tax

effects and certain other effects. Management, therefore, believes presentations of these non-GAAP financial measures provide useful supplemental information that is essential to a proper understanding of the operating results of the Company’s ongoing businesses, and management uses these non-GAAP financial measures to assess the performance of the Company’s ongoing businesses as related to prior financial periods. These non-GAAP disclosures should not be viewed as a substitute for operating results determined in accordance with GAAP, nor are they necessarily comparable to non-GAAP performance measures that may be presented by other companies. Where non-GAAP financial measures are used, the comparable GAAP financial measure, as well as the reconciliation to the comparable GAAP financial measure, can be found in the tables of this release.

Forward-Looking Statements

Certain statements in this press release may not be based on historical facts and should be considered “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements, including, without limitation, statements made in Mr. Makris’s quote, may be identified by reference to future periods or by the use of forward-looking terminology, such as “believe,” “budget,” “expect,” “foresee,” “anticipate,” “intend,” “indicate,” “target,” “estimate,” “plan,” “project,” “continue,” “contemplate,” “positions,” “prospects,” “predict,” or “potential,” by future conditional verbs such as “will,” “would,” “should,” “could,” “might” or “may,” or by variations of such words or by similar expressions. These forward-looking statements include, without limitation, statements relating to Simmons’ future growth, business strategies, lending capacity and lending activity, loan demand, revenue, assets, asset quality, profitability, dividends, net interest margin, non-interest revenue, share repurchase program, acquisition strategy, digital banking initiatives, the Company’s ability to recruit and retain key employees, the adequacy of the allowance for credit losses, future economic conditions and interest rates, and the adequacy of reserve levels for loans. Any forward-looking statement speaks only as of the date of this press release, and Simmons undertakes no obligation to update these forward-looking statements to reflect events or circumstances that occur after the date of this press release. By nature, forward-looking statements are based on various assumptions and involve inherent risk and uncertainties. Various factors, including, but not limited to, changes in economic conditions, changes in credit quality, changes in interest rates and related governmental policies, the effects of a government shutdown, changes in loan demand, changes in deposit flows, changes in real estate values, changes in the assumptions used in making the forward-looking statements, changes in the securities markets generally or the price of Simmons’ common stock specifically, changes in information technology affecting the financial industry, and changes in customer behaviors, including consumer spending, borrowing, and saving habits; changes in tariff policies; general economic and market conditions; changes in governmental administrations; market disruptions including pandemics or significant health hazards, severe weather conditions, natural disasters, terrorist activities, financial crises, political crises, war and other military conflicts (including the ongoing military conflicts between Russia and Ukraine) or other major events, or the prospect of these events; the soundness of other financial institutions and any indirect exposure related to the closings of other financial institutions and their impact on the broader market through other customers, suppliers and partners, or that the conditions which resulted in the liquidity concerns experienced by closed financial institutions may also adversely impact, directly or indirectly, other financial institutions and market participants with which the Company has commercial or deposit relationships; increased inflation; the loss of key employees; increased competition in the markets in which the Company operates and from non-bank financial institutions; increased unemployment; labor shortages; claims, damages, and fines related to litigation or government actions; changes in accounting principles relating to loan loss recognition (current expected credit losses); fraud that results in material losses or that we have not discovered yet that may result in material losses; the Company’s ability to manage and successfully integrate its mergers and acquisitions and to fully realize cost savings and other benefits associated with acquisitions; increased delinquency and foreclosure rates on commercial real estate loans; significant increases in nonaccrual loan balances; cyber or other information technology threats, attacks or events; reliance on third parties for key services; government legislation; and other factors, many of which are beyond the control of the Company, could cause actual results to differ materially from those projected in or contemplated by the forward-looking statements. In addition, there can be no guarantee that the board of directors (Board) of Simmons will approve a quarterly dividend in future quarters, and the timing, payment, and amount of future dividends (if any) is subject to, among other things, the discretion of the Board and may differ significantly from past dividends. Additional information on factors that might affect the Company’s financial results is included in the Company’s Form 10-K for the year ended December 31, 2024, the Company’s Form 10-Q for the quarter ended June 30, 2025, and other reports that the Company has filed with or furnished to the U.S. Securities and Exchange Commission (the SEC), all of which are available from the SEC on its website, www.sec.gov.

FOR MORE INFORMATION CONTACT:

Ed Bilek, EVP, Director of Investor and Media Relations

[email protected] or 205.612.3378 (cell)


Simmons First National Corporation		SFNC
Consolidated End of Period Balance Sheets
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30			Mar 31			Dec 31			Sep 30
	2025			2025			2025			2024			2024
($ in thousands)
ASSETS
Cash and noninterest bearing balances due from banks	$	377,604		$	398,081		$	423,171		$	429,705		$	398,321
Interest bearing balances due from banks and federal funds sold		266,013			246,381			211,115			257,672			205,081

Cash and cash equivalents		643,617			644,462			634,286			687,377			603,402
Interest bearing balances due from banks - time		100			100			100			100			100
Investment securities - held-to-maturity		—			3,591,531			3,615,556			3,636,636			3,658,700
Investment securities - available-for-sale		3,319,277			2,405,320			2,491,849			2,529,426			2,691,094
Mortgage loans held for sale		15,507			16,972			8,351			11,417			8,270
Assets held in trading accounts		12,695			—			—			—			—
Loans:
Loans		17,188,817			17,111,096			17,094,078			17,005,937			17,336,040
Allowance for credit losses on loans		(258,006	)		(253,537	)		(252,168	)		(235,019	)		(233,223	)

Net loans		16,930,811			16,857,559			16,841,910			16,770,918			17,102,817
Premises and equipment		568,343			573,160			573,616			585,431			584,366
Foreclosed assets and other real estate owned		6,386			8,794			8,976			9,270			1,299
Interest receivable		104,383			120,443			117,398			123,243			125,700
Bank owned life insurance		539,372			535,481			535,324			531,805			508,781
Goodwill		1,320,799			1,320,799			1,320,799			1,320,799			1,320,799
Other intangible assets		87,520			90,617			93,714			97,242			101,093
Other assets		659,352			528,382			551,112			572,385			562,983

Total assets	$	24,208,162		$	26,693,620		$	26,792,991		$	26,876,049		$	27,269,404

LIABILITIES AND STOCKHOLDERS’ EQUITY
Deposits:
Noninterest bearing transaction accounts	$	4,377,232		$	4,468,237		$	4,455,255		$	4,460,517		$	4,521,715
Interest bearing transaction accounts and savings deposits		10,932,914			11,176,791			11,265,554			10,982,022			10,863,945
Time deposits		4,527,587			6,179,962			5,963,811			6,443,211			6,549,774

Total deposits		19,837,733			21,824,990			21,684,620			21,885,750			21,935,434
Federal funds purchased and securities sold under agreements to repurchase		22,348			31,306			50,133			37,109			51,071
Other borrowings		18,832			634,349			884,863			745,372			1,045,878
Subordinated notes and debentures		651,250			366,369			366,331			366,293			366,255
Accrued interest and other liabilities		324,036			287,396			275,559			312,653			341,933

Total liabilities		20,854,199			23,144,410			23,261,506			23,347,177			23,740,571

Stockholders’ equity:
Common stock		1,447			1,260			1,259			1,257			1,256
Surplus		2,848,977			2,518,286			2,515,372			2,511,590			2,508,438
Undivided profits		817,022			1,410,564			1,382,564			1,376,935			1,355,000
Accumulated other comprehensive (loss) income		(313,483	)		(380,900	)		(367,710	)		(360,910	)		(335,861	)

Total stockholders’ equity		3,353,963			3,549,210			3,531,485			3,528,872			3,528,833

Total liabilities and stockholders’ equity	$	24,208,162		$	26,693,620		$	26,792,991		$	26,876,049		$	27,269,404

Page 1


Simmons First National Corporation		SFNC
Consolidated Statements of Income - Quarter-to-Date
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30		Mar 31		Dec 31		Sep 30
	2025			2025		2025		2024		2024
($ in thousands, except per share data)
INTEREST INCOME
Loans (including fees)	$	269,210		$	265,373	$	257,755	$	272,727	$	277,939
Interest bearing balances due from banks and federal funds sold		6,421			2,531		2,703		2,913		2,921
Investment securities		37,464			46,898		47,257		50,162		53,220
Mortgage loans held for sale		229			221		122		180		209
Assets held in trading accounts		99			—		—		—		—

TOTAL INTEREST INCOME		313,423			315,023		307,837		325,982		334,289

INTEREST EXPENSE
Time deposits		49,064			57,231		62,559		70,661		73,937
Other deposits		67,546			69,108		67,895		72,369		78,307
Federal funds purchased and securities sold under agreements to repurchase		72			59		113		119		138
Other borrowings		2,957			10,613		7,714		11,386		17,067
Subordinated notes and debentures		7,123			6,188		6,134		6,505		7,128

TOTAL INTEREST EXPENSE		126,762			143,199		144,415		161,040		176,577

NET INTEREST INCOME		186,661			171,824		163,422		164,942		157,712

PROVISION FOR CREDIT LOSSES
Provision for credit losses on loans		15,180			11,945		26,797		13,332		12,148

TOTAL PROVISION FOR CREDIT LOSSES		11,966			11,945		26,797		13,332		12,148

NET INTEREST INCOME AFTER PROVISION FOR CREDIT LOSSES		174,695			159,879		136,625		151,610		145,564

NONINTEREST INCOME
Service charges on deposit accounts		13,045			12,588		12,635		12,978		12,713
Debit and credit card fees		8,478			8,567		8,446		8,323		8,144
Wealth management fees		9,965			9,464		9,629		9,658		9,098
Mortgage lending income		2,259			1,687		2,013		1,828		1,956
Bank owned life insurance income		3,943			3,890		4,092		3,780		3,757
Other service charges and fees (includes insurance income)		1,474			1,321		1,333		1,426		1,509
Gain (loss) on sale of securities		(801,492	)		—		—		—		(28,393	)
Other income		6,141			4,837		8,007		5,565		8,346

TOTAL NONINTEREST INCOME		(756,187	)		42,354		46,155		43,558		17,130

NONINTEREST EXPENSE
Salaries and employee benefits		76,249			73,862		74,824		71,588		69,167
Occupancy expense, net		12,106			11,844		12,651		11,876		12,216
Furniture and equipment expense		5,275			5,474		5,465		5,671		5,612
Other real estate and foreclosure expense		200			216		198		317		87
Deposit insurance		5,175			4,917		5,391		5,550		5,571
Other operating expenses		43,027			42,276		46,051		46,115		44,540

TOTAL NONINTEREST EXPENSE		142,032			138,589		144,580		141,117		137,193

NET INCOME (LOSS) BEFORE INCOME TAXES		(723,524	)		63,644		38,200		54,051		25,501
Provision for income taxes		(160,732	)		8,871		5,812		5,732		761

NET INCOME (LOSS)	$	(562,792	)	$	54,773	$	32,388	$	48,319	$	24,740

BASIC EARNINGS PER SHARE	$	(4.01	)	$	0.43	$	0.26	$	0.38	$	0.20

DILUTED EARNINGS PER SHARE	$	(4.00	)	$	0.43	$	0.26	$	0.38	$	0.20

Page 2


Simmons First National Corporation		SFNC
Consolidated Risk-Based Capital
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30			Mar 31			Dec 31			Sep 30
	2025			2025			2025			2024			2024
($ in thousands)
Tier 1 capital
Stockholders’ equity	$	3,353,963		$	3,549,210		$	3,531,485		$	3,528,872		$	3,528,833
CECL transition provision ⁽¹⁾		—			—			—			30,873			30,873
Disallowed intangible assets, net of deferred tax		(1,376,255	)		(1,379,104	)		(1,381,953	)		(1,385,128	)		(1,388,549	)
Unrealized loss (gain) on AFS securities		313,483			380,900			367,710			360,910			335,861

Total Tier 1 capital		2,291,191			2,551,006			2,517,242			2,535,527			2,507,018

Tier 2 capital
Subordinated notes and debentures		651,250			366,369			366,331			366,293			366,255
Subordinated debt phase out		(198,000	)		(198,000	)		(132,000	)		(132,000	)		(132,000	)
Qualifying allowance for loan losses and reserve for unfunded commitments		248,710			258,079			257,769			222,313			220,517

Total Tier 2 capital		701,960			426,448			492,100			456,606			454,772

Total risk-based capital	$	2,993,151		$	2,977,454		$	3,009,342		$	2,992,133		$	2,961,790

Risk weighted assets	$	19,861,879		$	20,646,324		$	20,621,540		$	20,473,960		$	20,790,941

Adjusted average assets for leverage ratio	$	23,963,356		$	25,606,135		$	25,619,424		$	26,037,459		$	26,198,178

Ratios at end of quarter
Equity to assets		13.85	%		13.30	%		13.18	%		13.13	%		12.94	%
Tangible common equity to tangible assets ⁽²⁾		8.53	%		8.46	%		8.34	%		8.29	%		8.15	%
Common equity Tier 1 ratio (CET1)		11.54	%		12.36	%		12.21	%		12.38	%		12.06	%
Tier 1 leverage ratio		9.56	%		9.96	%		9.83	%		9.74	%		9.57	%
Tier 1 risk-based capital ratio		11.54	%		12.36	%		12.21	%		12.38	%		12.06	%
Total risk-based capital ratio		15.07	%		14.42	%		14.59	%		14.61	%		14.25	%

(1)

The Company has elected to use the CECL transition provision allowed for in the year of adopting ASC 326.

(2)

Calculations of tangible common equity to tangible assets and the reconciliations to GAAP are included in the schedules accompanying this release.

Page 3


Simmons First National Corporation		SFNC
Consolidated Investment Securities
For the Quarters Ended
(Unaudited)


	Sep 30		Jun 30		Mar 31		Dec 31		Sep 30
	2025		2025		2025		2024		2024
($ in thousands)
Investment Securities - End of Period
Held-to-Maturity
U.S. Government agencies	$	—	$	457,228	$	456,545	$	455,869	$	455,179
Mortgage-backed securities		—		1,024,313		1,048,170		1,070,032		1,093,070
State and political subdivisions		—		1,855,614		1,856,905		1,857,177		1,857,283
Other securities		—		254,376		253,936		253,558		253,168

Total held-to-maturity (net of credit losses)		—		3,591,531		3,615,556		3,636,636		3,658,700

Available-for-Sale
U.S. Treasury	$	—	$	400	$	699	$	996	$	1,290
U.S. Government agencies		48,355		49,498		52,318		54,547		58,397
Mortgage-backed securities		2,249,593		1,349,991		1,380,913		1,392,759		1,510,402
State and political subdivisions		845,371		807,842		832,898		858,182		898,178
Other securities		175,958		197,589		225,021		222,942		222,827

Total available-for-sale (net of credit losses)		3,319,277		2,405,320		2,491,849		2,529,426		2,691,094

Total investment securities (net of credit losses)	$	3,319,277	$	5,996,851	$	6,107,405	$	6,166,062	$	6,349,794

Fair value - HTM investment securities	$	—	$	2,891,974	$	2,929,625	$	2,949,951	$	3,109,610

Page 4


Simmons First National Corporation		SFNC
Consolidated Loans
For the Quarters Ended
(Unaudited)


	Sep 30		Jun 30		Mar 31		Dec 31		Sep 30
	2025		2025		2025		2024		2024
($ in thousands)
Loan Portfolio - End of Period
Consumer:
Credit cards	$	173,020	$	176,166	$	179,680	$	181,675	$	177,696
Other consumer		112,335		123,831		97,198		127,319		113,896

Total consumer		285,355		299,997		276,878		308,994		291,592
Real Estate:
Construction		2,874,823		2,784,578		2,778,245		2,789,249		2,796,378
Single-family residential		2,617,849		2,625,717		2,647,451		2,689,946		2,724,648
Other commercial real estate		7,875,649		7,961,412		8,051,304		7,912,336		7,992,437

Total real estate		13,368,321		13,371,707		13,477,000		13,391,531		13,513,463
Commercial:
Commercial		2,397,388		2,440,507		2,372,681		2,434,175		2,467,384
Agricultural		353,181		333,078		264,469		261,154		314,340

Total commercial		2,750,569		2,773,585		2,637,150		2,695,329		2,781,724
Other		784,572		665,807		703,050		610,083		749,261

Total loans	$	17,188,817	$	17,111,096	$	17,094,078	$	17,005,937	$	17,336,040

Page 5


Simmons First National Corporation		SFNC
Consolidated Allowance and Asset Quality
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30			Mar 31			Dec 31			Sep 30
	2025			2025			2025			2024			2024
($ in thousands)
Allowance for Credit Losses on Loans
Beginning balance	$	253,537		$	252,168		$	235,019		$	233,223		$	230,389
Loans charged off:
Credit cards		1,862			1,702			1,460			1,629			1,744
Other consumer		600			351			1,133			505			524
Real estate		1,350			1,450			4,425			3,810			159
Commercial		8,079			8,257			4,243			6,796			8,235

Total loans charged off		11,891			11,760			11,261			12,740			10,662
Recoveries of loans previously charged off:
Credit cards		257			334			211			391			231
Other consumer		303			294			306			279			275
Real estate		115			87			99			275			403
Commercial		505			469			997			259			439

Total recoveries		1,180			1,184			1,613			1,204			1,348

Net loans charged off		10,711			10,576			9,648			11,536			9,314
Provision for credit losses on loans		15,180			11,945			26,797			13,332			12,148

Balance, end of quarter	$	258,006		$	253,537		$	252,168		$	235,019		$	233,223

Nonperforming assets
Nonperforming loans:
Nonaccrual loans	$	153,516		$	156,453		$	151,897		$	110,154		$	100,865
Loans past due 90 days or more		423			709			494			603			830

Total nonperforming loans		153,939			157,162			152,391			110,757			101,695

Other nonperforming assets:
Foreclosed assets and other real estate owned		6,386			8,794			8,976			9,270			1,299
Other nonperforming assets		392			759			978			1,202			1,311

Total other nonperforming assets		6,778			9,553			9,954			10,472			2,610

Total nonperforming assets	$	160,717		$	166,715		$	162,345		$	121,229		$	104,305

Ratios
Allowance for credit losses on loans to total loans		1.50	%		1.48	%		1.48	%		1.38	%		1.35	%
Allowance for credit losses to nonperforming loans		168	%		161	%		165	%		212	%		229	%
Nonperforming loans to total loans		0.90	%		0.92	%		0.89	%		0.65	%		0.59	%
Nonperforming assets to total assets		0.66	%		0.62	%		0.61	%		0.45	%		0.38	%
Annualized net charge offs to average loans (QTD)		0.25	%		0.25	%		0.23	%		0.27	%		0.22	%
Annualized net charge offs to average loans (YTD)		0.24	%		0.24	%		0.23	%		0.22	%		0.20	%
Annualized net credit card charge offs to average credit card loans (QTD)		3.64	%		2.99	%		2.72	%		2.63	%		3.23	%

Page 6


Simmons First National Corporation		SFNC
Consolidated - Average Balance Sheet and Net Interest Income Analysis
For the Quarters Ended
(Unaudited)


	Three Months Ended Sep 2025							Three Months Ended Jun 2025							Three Months Ended Sep 2024
($ in thousands)	Average Balance		Income/ Expense		Yield/ Rate			Average Balance		Income/ Expense		Yield/ Rate			Average Balance		Income/ Expense		Yield/ Rate
ASSETS
Earning assets:
Interest bearing balances due from banks and federal funds sold	$	566,344	$	6,421		4.50	%	$	219,928	$	2,531		4.62	%	$	204,505	$	2,921		5.68	%
Investment securities - taxable		2,751,493		29,183		4.21	%		3,483,805		31,233		3.60	%		3,826,934		37,473		3.90	%
Investment securities - non-taxable (FTE)		1,242,936		11,210		3.58	%		2,564,037		21,210		3.32	%		2,617,532		21,318		3.24	%
Mortgage loans held for sale		13,776		229		6.60	%		13,063		221		6.79	%		12,425		209		6.69	%
Assets held in trading accounts		11,305		99		3.47	%		—		—		0.00	%		—		—		0.00	%
Other loans held for sale		—		—		0.00	%		—		—		0.00	%		—		—		0.00	%
Loans—including fees (FTE)		16,976,231		270,092		6.31	%		17,046,802		266,250		6.26	%		17,208,162		278,766		6.44	%

Total interest earning assets (FTE)		21,562,085		317,234		5.84	%		23,327,635		321,445		5.53	%		23,869,558		340,687		5.68	%
Non-earning assets		3,352,837							3,317,496							3,346,882

Total assets	$	24,914,922						$	26,645,131						$	27,216,440

LIABILITIES AND STOCKHOLDERS’ EQUITY
Interest bearing liabilities:
Interest bearing transaction and savings accounts	$	11,043,132	$	67,546		2.43	%	$	11,220,060	$	69,108		2.47	%	$	10,826,514	$	78,307		2.88	%
Time deposits		5,116,070		49,064		3.80	%		5,820,499		57,231		3.94	%		6,355,801		73,937		4.63	%

Total interest bearing deposits		16,159,202		116,610		2.86	%		17,040,559		126,339		2.97	%		17,182,315		152,244		3.52	%
Federal funds purchased and securities sold under agreement to repurchase		23,306		72		1.23	%		32,565		59		0.73	%		51,830		138		1.06	%
Other borrowings		268,278		2,957		4.37	%		960,817		10,613		4.43	%		1,252,435		17,067		5.42	%
Subordinated notes and debentures		407,922		7,123		6.93	%		366,350		6,188		6.77	%		366,236		7,128		7.74	%

Total interest bearing liabilities		16,858,708		126,762		2.98	%		18,400,291		143,199		3.12	%		18,852,816		176,577		3.73	%

Noninterest bearing liabilities:
Noninterest bearing deposits		4,369,941							4,390,454							4,535,105
Other liabilities		317,965							308,223							323,378

Total liabilities		21,546,614							23,098,968							23,711,299
Stockholders’ equity		3,368,308							3,546,163							3,505,141

Total liabilities and stockholders’ equity	$	24,914,922						$	26,645,131						$	27,216,440

Net interest income (FTE)			$	190,472						$	178,246						$	164,110

Net interest spread (FTE)						2.86	%						2.41	%						1.95	%

Net interest margin (FTE)						3.50	%						3.06	%						2.74	%

Page 7


Simmons First National Corporation		SFNC
Consolidated - Selected Financial Data
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30			Mar 31			Dec 31			Sep 30
	2025			2025			2025			2024			2024
($ in thousands, except share data)
QUARTER-TO-DATE
Financial Highlights - As Reported
Net Income (loss)	$	(562,792	)	$	54,773		$	32,388		$	48,319		$	24,740
Diluted earnings per share		(4.00	)		0.43			0.26			0.38			0.20
Return on average assets		-8.96	%		0.82	%		0.49	%		0.71	%		0.36	%
Return on average common equity		-66.29	%		6.20	%		3.69	%		5.43	%		2.81	%
Return on tangible common equity (non-GAAP) ⁽¹⁾		-113.56	%		10.73	%		6.61	%		9.59	%		5.27	%
Net interest margin (FTE)		3.50	%		3.06	%		2.95	%		2.87	%		2.74	%
Efficiency ratio ⁽²⁾		-25.11	%		62.82	%		66.94	%		65.66	%		75.70	%
FTE adjustment		3,811			6,422			6,414			6,424			6,398
Average diluted shares outstanding		140,648,704			126,406,453			126,336,557			126,232,084			125,999,269
Cash dividends declared per common share		0.213			0.213			0.213			0.210			0.210
Accretable yield on acquired loans		725			1,263			1,084			1,863			1,496
Financial Highlights - Adjusted (non-GAAP) ⁽¹⁾
Adjusted earnings	$	64,930		$	56,071		$	33,122		$	49,634		$	46,005
Adjusted diluted earnings per share		0.46			0.44			0.26			0.39			0.37
Adjusted return on average assets		1.03	%		0.84	%		0.50	%		0.73	%		0.67	%
Adjusted return on average common equity		7.65	%		6.34	%		3.77	%		5.57	%		5.22	%
Adjusted return on tangible common equity		13.62	%		10.97	%		6.75	%		9.83	%		9.34	%
Adjusted efficiency ratio ⁽²⁾		57.72	%		60.52	%		64.75	%		62.89	%		63.38	%
YEAR-TO-DATE
Financial Highlights - GAAP
Net Income (loss)	$	(475,631	)	$	87,161		$	32,388		$	152,693		$	104,374
Diluted earnings per share		(3.63	)		0.69			0.26			1.21			0.83
Return on average assets		-2.44	%		0.66	%		0.49	%		0.56	%		0.51	%
Return on average common equity		-18.21	%		4.94	%		3.69	%		4.38	%		4.02	%
Return on tangible common equity (non-GAAP) ⁽¹⁾		-30.13	%		8.67	%		6.61	%		7.96	%		7.39	%
Net interest margin (FTE)		3.17	%		3.01	%		2.95	%		2.74	%		2.70	%
Efficiency ratio ⁽²⁾		-329.30	%		64.86	%		66.94	%		69.57	%		71.00	%
FTE adjustment		16,647			12,836			6,414			25,820			19,396
Average diluted shares outstanding		131,132,891			126,325,650			126,336,557			126,115,606			125,910,260
Cash dividends declared per common share		0.638			0.425			0.213			0.840			0.630
Financial Highlights - Adjusted (non-GAAP) ⁽¹⁾
Adjusted earnings	$	154,123		$	89,193		$	33,122		$	177,887		$	128,253
Adjusted diluted earnings per share		1.18			0.71			0.26			1.41			1.02
Adjusted return on average assets		0.79	%		0.67	%		0.50	%		0.65	%		0.63	%
Adjusted return on average common equity		5.90	%		5.06	%		3.77	%		5.10	%		4.94	%
Adjusted return on tangible common equity		10.37	%		8.86	%		6.75	%		9.18	%		8.96	%
Adjusted efficiency ratio ⁽²⁾		60.90	%		62.62	%		64.75	%		64.56	%		65.14	%
END OF PERIOD
Book value per share	$	23.18		$	28.17		$	28.04		$	28.08		$	28.11
Tangible book value per share		13.45			16.97			16.81			16.80			16.78
Shares outstanding		144,703,075			125,996,248			125,926,822			125,651,540			125,554,598
Full-time equivalent employees		2,883			2,947			2,949			2,946			2,972
Total number of financial centers		223			223			222			222			234

(1)

Non-GAAP measurement that management believes aids in the understanding and discussion of results. Reconciliations to GAAP are included in the schedules accompanying this release.

(2)

Efficiency ratio is noninterest expense as a percent of net interest income (fully taxable equivalent) and noninterest revenues. Adjusted efficiency ratio is noninterest expense before foreclosed property expense, amortization of intangibles and certain adjusting items as a percent of net interest income (fully taxable equivalent) and noninterest revenues, excluding gains and losses from securities transactions and certain adjusting items, and is a non-GAAP measurement.

Page 8


Simmons First National Corporation		SFNC
Reconciliation Of Non-GAAP Financial Measures - Adjusted Earnings - Quarter-to-Date
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30			Mar 31			Dec 31			Sep 30
	2025			2025			2025			2024			2024
(in thousands, except per share data)
QUARTER-TO-DATE
Net income (loss)	$	(562,792	)	$	54,773		$	32,388		$	48,319		$	24,740
Certain items (non-GAAP)
Loss on early extinguishment of debt		570			—			—			—			—
Early retirement program		305			1,594			—			200			(1	)
Termination of vendor and software services		—			—			—			—			(13	)
Loss (gain) on sale of securities		801,492			—			—			—			28,393
Branch right sizing (net)		2,004			163			994			1,581			410
Tax effect of certain items ⁽¹⁾		(176,649	)		(459	)		(260	)		(466	)		(7,524	)

Certain items, net of tax		627,722			1,298			734			1,315			21,265

Adjusted earnings (non-GAAP) ⁽²⁾	$	64,930		$	56,071		$	33,122		$	49,634		$	46,005

Diluted earnings per share	$	(4.00	)	$	0.43		$	0.26		$	0.38		$	0.20
Certain items (non-GAAP)
Loss on early extinguishment of debt		—			—			—			—			—
Early retirement program		—			0.01			—			—			—
Termination of vendor and software services		—			—			—			—			—
Loss (gain) on sale of securities		5.70			—			—			—			0.23
Branch right sizing (net)		0.01			—			—			0.01			—
Tax effect of certain items ⁽¹⁾		(1.25	)		—			—			—			(0.06	)

Certain items, net of tax		4.46			0.01			—			0.01			0.17

Adjusted diluted earnings per share (non-GAAP)	$	0.46		$	0.44		$	0.26		$	0.39		$	0.37

(1)

Actual tax rate of 21.946% on 2025 loss on sale of securities. Effective rate of 26.135% on all other items.

(2)

In this press release, “Adjusted Earnings” may also be referred to as “Adjusted Net Income.”

Reconciliation of Certain Noninterest Income and Expense Items (non-GAAP)


QUARTER-TO-DATE
Noninterest income	$	(756,187	)	$	42,354		$	46,155		$	43,558		$	17,130
Certain noninterest income items
Loss on early extinguishment of debt		570			—			—			—			—
Loss (gain) on sale of securities		801,492			—			—			—			28,393

Adjusted noninterest income (non-GAAP)	$	45,875		$	42,354		$	46,155		$	43,558		$	45,523

Other income	$	6,141		$	4,837		$	8,007		$	5,565		$	8,346
Certain other income items
Loss on early extinguishment of debt		570			—			—			—			—

Adjusted other income (non-GAAP)	$	6,711		$	4,837		$	8,007		$	5,565		$	8,346

Noninterest expense	$	142,032		$	138,589		$	144,580		$	141,117		$	137,193
Certain noninterest expense items
Early retirement program		(305	)		(1,594	)		—			(200	)		1
Termination of vendor and software services		—			—			—			—			13
Branch right sizing expense		(2,004	)		(163	)		(994	)		(1,581	)		(410	)

Adjusted noninterest expense (non-GAAP)		139,723			136,832			143,586			139,336			136,797
Less: Fraud event		—			—			(4,300	)		—			—

Adjusted noninterest expense, excluding fraud event (non-GAAP)	$	139,723		$	136,832		$	139,286		$	139,336		$	136,797

Salaries and employee benefits	$	76,249		$	73,862		$	74,824		$	71,588		$	69,167
Certain salaries and employee benefits items
Early retirement program		(305	)		(1,594	)		—			(200	)		1
Other		(1	)		1			—			—			(1	)

Adjusted salaries and employee benefits (non-GAAP)	$	75,943		$	72,269		$	74,824		$	71,388		$	69,167

Other operating expenses	$	43,027		$	42,276		$	46,051		$	46,115		$	44,540
Certain other operating expenses items
Termination of vendor and software services		—			—			—			—			13
Branch right sizing expense		(1,556	)		255			(161	)		(1,457	)		(184	)

Adjusted other operating expenses (non-GAAP)	$	41,471		$	42,531		$	45,890		$	44,658		$	44,369

Page 9


Simmons First National Corporation		SFNC
Reconciliation Of Non-GAAP Financial Measures - Adjusted Earnings - Year-to-Date
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30			Mar 31			Dec 31			Sep 30
	2025			2025			2025			2024			2024
(in thousands, except per share data)
YEAR-TO-DATE
Net income (loss)	$	(475,631	)	$	87,161		$	32,388		$	152,693		$	104,374
Certain items (non-GAAP)
Loss on early extinguishment of debt		570			—			—			—			—
FDIC Deposit Insurance special assessment		—			—			—			1,832			1,832
Early retirement program		1,899			1,594			—			536			336
Termination of vendor and software services		—			—			—			602			602
Loss (gain) on sale of securities		801,492			—			—			28,393			28,393
Branch right sizing (net)		3,161			1,157			994			2,746			1,165
Tax effect of certain items ⁽¹⁾		(177,368	)		(719	)		(260	)		(8,915	)		(8,449	)

Certain items, net of tax		629,754			2,032			734			25,194			23,879

Adjusted earnings (non-GAAP) ⁽²⁾	$	154,123		$	89,193		$	33,122		$	177,887		$	128,253

Diluted earnings per share	$	(3.63	)	$	0.69		$	0.26		$	1.21		$	0.83
Certain items (non-GAAP)
Loss on early extinguishment of debt		—			—			—			—			—
FDIC Deposit Insurance special assessment		—			—			—			0.02			0.02
Early retirement program		0.02			0.01			—			—			—
Termination of vendor and software services		—			—			—			—			—
Loss (gain) on sale of securities		6.11			—			—			0.23			0.23
Branch right sizing (net)		0.02			0.01			—			0.02			0.01
Tax effect of certain items ⁽¹⁾		(1.34	)		—			—			(0.07	)		(0.07	)

Certain items, net of tax		4.81			0.02			—			0.20			0.19

Adjusted diluted earnings per share (non-GAAP)	$	1.18		$	0.71		$	0.26		$	1.41		$	1.02

(1)

Actual tax rate of 21.946% on 2025 loss on sale of securities. Effective rate of 26.135% on all other items.

(2)

In this press release, “Adjusted Earnings” may also be referred to as “Adjusted Net Income.”

Reconciliation of Certain Noninterest Income and Expense Items (non-GAAP)


YEAR-TO-DATE
Noninterest income	$	(667,678	)	$	88,509		$	46,155		$	147,171		$	103,613
Certain noninterest income items
Loss on early extinguishment of debt		570			—			—			—			—
Loss (gain) on sale of securities		801,492			—			—			28,393			28,393

Adjusted noninterest income (non-GAAP)	$	134,384		$	88,509		$	46,155		$	175,564		$	132,006

Other income	$	18,985		$	12,844		$	8,007		$	27,493		$	21,928
Certain other income items
Loss on early extinguishment of debt		570			—			—			—			—

Adjusted other income (non-GAAP)	$	19,555		$	12,844		$	8,007		$	27,493		$	21,928

Noninterest expense	$	425,201		$	283,169		$	144,580		$	557,543		$	416,426
Certain noninterest expense items
Early retirement program		(1,899	)		(1,594	)		—			(536	)		(336	)
FDIC Deposit Insurance special assessment		—			—			—			(1,832	)		(1,832	)
Termination of vendor and software services		—			—			—			(602	)		(602	)
Branch right sizing expense		(3,161	)		(1,157	)		(994	)		(2,746	)		(1,165	)

Adjusted noninterest expense (non-GAAP)		420,141			280,418			143,586			551,827			412,491
Less: Fraud event		(4,300	)		(4,300	)		(4,300	)		—			—

Adjusted noninterest expense, excluding fraud event (non-GAAP)	$	415,841		$	276,118		$	139,286		$	551,827		$	412,491

Salaries and employee benefits	$	224,935		$	148,686		$	74,824		$	284,124		$	212,536
Certain salaries and employee benefits items
Early retirement program		(1,899	)		(1,594	)		—			(536	)		(336	)
Other		—			1			—			—			—

Adjusted salaries and employee benefits (non-GAAP)	$	223,036		$	147,093		$	74,824		$	283,588		$	212,200

Other operating expenses	$	131,354		$	88,327		$	46,051		$	178,520		$	132,405
Certain other operating expenses items
Termination of vendor and software services		—			—			—			(602	)		(602	)
Branch right sizing expense		(1,462	)		94			(161	)		(2,116	)		(659	)

Adjusted other operating expenses (non-GAAP)	$	129,892		$	88,421		$	45,890		$	175,802		$	131,144

Page 10


Simmons First National Corporation		SFNC
Reconciliation Of Non-GAAP Financial Measures - End of Period
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30			Mar 31			Dec 31			Sep 30
	2025			2025			2025			2024			2024
($ in thousands, except per share data)
Calculation of Tangible Common Equity and the Ratio of Tangible Common Equity to Tangible Assets
Total common stockholders’ equity	$	3,353,963		$	3,549,210		$	3,531,485		$	3,528,872		$	3,528,833
Intangible assets:
Goodwill		(1,320,799	)		(1,320,799	)		(1,320,799	)		(1,320,799	)		(1,320,799	)
Other intangible assets		(87,520	)		(90,617	)		(93,714	)		(97,242	)		(101,093	)

Total intangibles		(1,408,319	)		(1,411,416	)		(1,414,513	)		(1,418,041	)		(1,421,892	)

Tangible common stockholders’ equity	$	1,945,644		$	2,137,794		$	2,116,972		$	2,110,831		$	2,106,941

Total assets	$	24,208,162		$	26,693,620		$	26,792,991		$	26,876,049		$	27,269,404
Intangible assets:
Goodwill		(1,320,799	)		(1,320,799	)		(1,320,799	)		(1,320,799	)		(1,320,799	)
Other intangible assets		(87,520	)		(90,617	)		(93,714	)		(97,242	)		(101,093	)

Total intangibles		(1,408,319	)		(1,411,416	)		(1,414,513	)		(1,418,041	)		(1,421,892	)

Tangible assets	$	22,799,843		$	25,282,204		$	25,378,478		$	25,458,008		$	25,847,512

Ratio of common equity to assets		13.85	%		13.30	%		13.18	%		13.13	%		12.94	%

Ratio of tangible common equity to tangible assets		8.53	%		8.46	%		8.34	%		8.29	%		8.15	%

Calculation of Tangible Book Value per Share
Total common stockholders’ equity	$	3,353,963		$	3,549,210		$	3,531,485		$	3,528,872		$	3,528,833
Intangible assets:
Goodwill		(1,320,799	)		(1,320,799	)		(1,320,799	)		(1,320,799	)		(1,320,799	)
Other intangible assets		(87,520	)		(90,617	)		(93,714	)		(97,242	)		(101,093	)

Total intangibles		(1,408,319	)		(1,411,416	)		(1,414,513	)		(1,418,041	)		(1,421,892	)

Tangible common stockholders’ equity	$	1,945,644		$	2,137,794		$	2,116,972		$	2,110,831		$	2,106,941

Shares of common stock outstanding		144,703,075			125,996,248			125,926,822			125,651,540			125,554,598

Book value per common share	$	23.18		$	28.17		$	28.04		$	28.08		$	28.11

Tangible book value per common share	$	13.45		$	16.97		$	16.81		$	16.80		$	16.78

Calculation of Coverage Ratio of Uninsured, Non-Collateralized Deposits
Uninsured deposits at Simmons Bank	$	9,565,766		$	8,407,847		$	8,614,833		$	8,467,291		$	8,355,496
Less: Collateralized deposits (excluding portion that is FDIC insured)		2,169,362			2,691,215			3,005,328			2,790,339			2,710,167
Less: Intercompany eliminations		2,937,147			1,121,932			1,073,500			1,045,734			986,626

Total uninsured, non-collateralized deposits	$	4,459,257		$	4,594,700		$	4,536,005		$	4,631,218		$	4,658,703

FHLB borrowing availability	$	6,134,000		$	5,133,000		$	4,432,000		$	4,716,000		$	4,955,000
Unpledged securities		1,575,000			3,697,000			4,197,000			4,103,000			4,110,000
Fed funds lines, Fed discount window and Bank Term Funding Program ⁽¹⁾		1,824,000			1,894,000			1,780,000			2,081,000			2,109,000

Additional liquidity sources	$	9,533,000		$	10,724,000		$	10,409,000		$	10,900,000		$	11,174,000

Uninsured, non-collateralized deposit coverage ratio		2.1			2.3			2.3			2.4			2.4

(1) The Bank Term Funding Program closed for new loans on March 11, 2024. At no time did Simmons borrow funds under this program.
Calculation of Net Charge Off Ratio
Net charge offs	$	10,711		$	10,576		$	9,648		$	11,536		$	9,314
Less: Net charge offs from run-off portfolio⁽¹⁾		500			1,100			1,900			2,500			3,500

Net charge offs excluding run-off portfolio	$	10,211		$	9,476		$	7,748		$	9,036		$	5,814

Average total loans	$	16,976,231		$	17,046,802		$	16,920,050		$	17,212,034		$	17,208,162

Annualized net charge offs to average loans (NCO ratio)		0.25	%		0.25	%		0.23	%		0.27	%		0.22	%

NCO ratio, excluding net charge offs associated with run-off portfolio (annualized)		0.24	%		0.22	%		0.19	%		0.21	%		0.13	%

(1)

Run-off portfolio consists of asset based lending and small equipment finance portfolios obtained in acquisitions.

Page 11


Simmons First National Corporation		SFNC
Reconciliation Of Non-GAAP Financial Measures - Quarter-to-Date
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30			Mar 31			Dec 31			Sep 30
	2025			2025			2025			2024			2024
($ in thousands)
Calculation of Adjusted Return on Average Assets
Net income (loss)	$	(562,792	)	$	54,773		$	32,388		$	48,319		$	24,740
Certain items (non-GAAP)
Loss on early extinguishment of debt		570			—			—			—			—
Early retirement program		305			1,594			—			200			(1	)
Termination of vendor and software services		—			—			—			—			(13	)
Loss (gain) on sale of securities		801,492			—			—			—			28,393
Branch right sizing (net)		2,004			163			994			1,581			410
Tax effect of certain items ⁽²⁾		(176,649	)		(459	)		(260	)		(466	)		(7,524	)

Adjusted earnings (non-GAAP)	$	64,930		$	56,071		$	33,122		$	49,634		$	46,005

Average total assets	$	24,914,922		$	26,645,131		$	26,678,628		$	27,078,943		$	27,216,440

Return on average assets		-8.96	%		0.82	%		0.49	%		0.71	%		0.36	%

Adjusted return on average assets (non-GAAP)		1.03	%		0.84	%		0.50	%		0.73	%		0.67	%

Calculation of Return on Tangible Common Equity
Net income (loss) available to common stockholders	$	(562,792	)	$	54,773		$	32,388		$	48,319		$	24,740
Amortization of intangibles, net of taxes		2,287			2,289			2,605			2,843			2,845

Total income available to common stockholders	$	(560,505	)	$	57,062		$	34,993		$	51,162		$	27,585

Certain items (non-GAAP)
Loss on early extinguishment of debt		570			—			—			—			—
Early retirement program		305			1,594			—			200			(1	)
Termination of vendor and software services		—			—			—			—			(13	)
Loss (gain) on sale of securities		801,492			—			—			—			28,393
Branch right sizing (net)		2,004			163			994			1,581			410
Tax effect of certain items ⁽²⁾		(176,649	)		(459	)		(260	)		(466	)		(7,524	)

Adjusted earnings (non-GAAP)		64,930			56,071			33,122			49,634			46,005
Amortization of intangibles, net of taxes		2,287			2,289			2,605			2,843			2,845

Total adjusted earnings available to common stockholders (non-GAAP)	$	67,217		$	58,360		$	35,727		$	52,477		$	48,850

Average common stockholders’ equity	$	3,368,308		$	3,546,163		$	3,564,469		$	3,543,146		$	3,505,141
Average intangible assets:
Goodwill		(1,320,799	)		(1,320,799	)		(1,320,799	)		(1,320,799	)		(1,320,799	)
Other intangibles		(89,349	)		(92,432	)		(95,787	)		(99,405	)		(103,438	)

Total average intangibles		(1,410,148	)		(1,413,231	)		(1,416,586	)		(1,420,204	)		(1,424,237	)

Average tangible common stockholders’ equity (non-GAAP)	$	1,958,160		$	2,132,932		$	2,147,883		$	2,122,942		$	2,080,904

Return on average common equity		-66.29	%		6.20	%		3.69	%		5.43	%		2.81	%

Return on tangible common equity		-113.56	%		10.73	%		6.61	%		9.59	%		5.27	%

Adjusted return on average common equity (non-GAAP)		7.65	%		6.34	%		3.77	%		5.57	%		5.22	%

Adjusted return on tangible common equity (non-GAAP)		13.62	%		10.97	%		6.75	%		9.83	%		9.34	%

Calculation of Efficiency Ratio and Adjusted Efficiency Ratio *⁽¹⁾*
Noninterest expense (efficiency ratio numerator)	$	142,032		$	138,589		$	144,580		$	141,117		$	137,193
Certain noninterest expense items (non-GAAP)
Early retirement program		(305	)		(1,594	)		—			(200	)		1
Termination of vendor and software services		—			—			—			—			13
Branch right sizing expense		(2,004	)		(163	)		(994	)		(1,581	)		(410	)
Other real estate and foreclosure expense adjustment		(200	)		(216	)		(198	)		(317	)		(87	)
Amortization of intangibles adjustment		(3,097	)		(3,098	)		(3,527	)		(3,850	)		(3,851	)

Adjusted efficiency ratio numerator	$	136,426		$	133,518		$	139,861		$	135,169		$	132,859

Net interest income	$	186,661		$	171,824		$	163,422		$	164,942		$	157,712
Noninterest income		(756,187	)		42,354			46,155			43,558			17,130
Fully tax-equivalent adjustment (effective tax rate of 26.135%)		3,811			6,422			6,414			6,424			6,398

Efficiency ratio denominator		(565,715	)		220,600			215,991			214,924			181,240
Certain noninterest income items (non-GAAP)
Loss on early extinguishment of debt		570			—			—			—			—
(Gain) loss on sale of securities		801,492			—			—			—			28,393

Adjusted efficiency ratio denominator	$	236,347		$	220,600		$	215,991		$	214,924		$	209,633

Efficiency ratio⁽¹⁾		-25.11	%		62.82	%		66.94	%		65.66	%		75.70	%

Adjusted efficiency ratio (non-GAAP)⁽¹⁾		57.72	%		60.52	%		64.75	%		62.89	%		63.38	%

(1)

(2)

Actual tax rate of 21.946% on 2025 loss on sale of securities. Effective rate of 26.135% on all other items.

Page 12


Simmons First National Corporation		SFNC
Reconciliation Of Non-GAAP Financial Measures - Quarter-to-Date (continued)
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30		Mar 31		Dec 31		Sep 30
	2025			2025		2025		2024		2024
($ in thousands)
Calculation of Total Revenue and Adjusted Total Revenue
Net interest income	$	186,661		$	171,824	$	163,422	$	164,942	$	157,712
Noninterest income		(756,187	)		42,354		46,155		43,558		17,130

Total revenue		(569,526	)		214,178		209,577		208,500		174,842
Certain items, pre-tax (non-GAAP)
Plus: Loss on early extinguishment of debt		570			—		—		—		—
Less: Gain (loss) on sale of securities		(801,492	)		—		—		—		(28,393	)

Adjusted total revenue	$	232,536		$	214,178	$	209,577	$	208,500	$	203,235

Calculation of Pre-Provision Net Revenue (PPNR)
Net interest income	$	186,661		$	171,824	$	163,422	$	164,942	$	157,712
Noninterest income		(756,187	)		42,354		46,155		43,558		17,130

Total revenue		(569,526	)		214,178		209,577		208,500		174,842
Less: Noninterest expense		142,032			138,589		144,580		141,117		137,193

Pre-Provision Net Revenue (PPNR)	$	(711,558	)	$	75,589	$	64,997	$	67,383	$	37,649

Calculation of Adjusted Pre-Provision Net Revenue
Pre-Provision Net Revenue (PPNR)	$	(711,558	)	$	75,589	$	64,997	$	67,383	$	37,649
Certain items, pre-tax (non-GAAP)
Plus: Loss on early extinguishment of debt		570			—		—		—		—
Plus: Loss (gain) on sale of securities		801,492			—		—		—		28,393
Plus: Early retirement program costs		305			1,594		—		200		(1	)
Plus: Termination of vendor and software services		—			—		—		—		(13	)
Plus: Branch right sizing costs (net)		2,004			163		994		1,581		410

Adjusted Pre-Provision Net Revenue	$	92,813		$	77,346	$	65,991	$	69,164	$	66,438

Page 13


Simmons First National Corporation		SFNC
Reconciliation Of Non-GAAP Financial Measures - Year-to-Date
For the Quarters Ended
(Unaudited)


	Sep 30			Jun 30			Mar 31			Dec 31			Sep 30
	2025			2025			2025			2024			2024
($ in thousands)
Calculation of Adjusted Return on Average Assets
Net income (loss)	$	(475,631	)	$	87,161		$	32,388		$	152,693		$	104,374
Certain items (non-GAAP)
Loss on early extinguishment of debt		570			—			—			—			—
FDIC Deposit Insurance special assessment		—			—			—			1,832			1,832
Early retirement program		1,899			1,594			—			536			336
Termination of vendor and software services		—			—			—			602			602
Loss (gain) on sale of securities		801,492			—			—			28,393			28,393
Branch right sizing (net)		3,161			1,157			994			2,746			1,165
Tax effect of certain items ⁽²⁾		(177,368	)		(719	)		(260	)		(8,915	)		(8,449	)

Adjusted earnings (non-GAAP)	$	154,123		$	89,193		$	33,122		$	177,887		$	128,253

Average total assets	$	26,073,100		$	26,661,787		$	26,678,628		$	27,214,647		$	27,260,212

Return on average assets		-2.44	%		0.66	%		0.49	%		0.56	%		0.51	%

Adjusted return on average assets (non-GAAP)		0.79	%		0.67	%		0.50	%		0.65	%		0.63	%

Calculation of Return on Tangible Common Equity
Net income (loss) available to common stockholders	$	(475,631	)	$	87,161		$	32,388		$	152,693		$	104,374
Amortization of intangibles, net of taxes		7,181			4,894			2,605			11,377			8,534

Total income available to common stockholders	$	(468,450	)	$	92,055		$	34,993		$	164,070		$	112,908

Certain items (non-GAAP)
Loss on early extinguishment of debt		570			—			—			—			—
FDIC Deposit Insurance special assessment		—			—			—			1,832			1,832
Early retirement program		1,899			1,594			—			536			336
Termination of vendor and software services		—			—			—			602			602
Loss (gain) on sale of securities		801,492			—			—			28,393			28,393
Branch right sizing (net)		3,161			1,157			994			2,746			1,165
Tax effect of certain items ⁽²⁾		(177,368	)		(719	)		(260	)		(8,915	)		(8,449	)

Adjusted earnings (non-GAAP)		154,123			89,193			33,122			177,887			128,253
Amortization of intangibles, net of taxes		7,181			4,894			2,605			11,377			8,534

Total adjusted earnings available to common stockholders (non-GAAP)	$	161,304		$	94,087		$	35,727		$	189,264		$	136,787

Average common stockholders’ equity	$	3,492,261		$	3,555,265		$	3,564,469		$	3,486,822		$	3,467,908
Average intangible assets:
Goodwill		(1,320,799	)		(1,320,799	)		(1,320,799	)		(1,320,799	)		(1,320,799	)
Other intangibles		(92,499	)		(94,100	)		(95,787	)		(105,239	)		(107,197	)

Total average intangibles		(1,413,298	)		(1,414,899	)		(1,416,586	)		(1,426,038	)		(1,427,996	)

Average tangible common stockholders’ equity (non-GAAP)	$	2,078,963		$	2,140,366		$	2,147,883		$	2,060,784		$	2,039,912

Return on average common equity		-18.21	%		4.94	%		3.69	%		4.38	%		4.02	%

Return on tangible common equity		-30.13	%		8.67	%		6.61	%		7.96	%		7.39	%

Adjusted return on average common equity (non-GAAP)		5.90	%		5.06	%		3.77	%		5.10	%		4.94	%

Adjusted return on tangible common equity (non-GAAP)		10.37	%		8.86	%		6.75	%		9.18	%		8.96	%

Calculation of Efficiency Ratio and Adjusted Efficiency Ratio *⁽¹⁾*
Noninterest expense (efficiency ratio numerator)	$	425,201		$	283,169		$	144,580		$	557,543		$	416,426
Certain noninterest expense items (non-GAAP)
Early retirement program		(1,899	)		(1,594	)		—			(536	)		(336	)
FDIC Deposit Insurance special assessment		—			—			—			(1,832	)		(1,832	)
Termination of vendor and software services		—			—			—			(602	)		(602	)
Branch right sizing expense		(3,161	)		(1,157	)		(994	)		(2,746	)		(1,165	)
Other real estate and foreclosure expense adjustment		(614	)		(414	)		(198	)		(700	)		(383	)
Amortization of intangibles adjustment		(9,722	)		(6,625	)		(3,527	)		(15,403	)		(11,553	)

Adjusted efficiency ratio numerator	$	409,805		$	273,379		$	139,861		$	535,724		$	400,555

Net interest income	$	521,907		$	335,246		$	163,422		$	628,465		$	463,523
Noninterest income		(667,678	)		88,509			46,155			147,171			103,613
Fully tax-equivalent adjustment (effective tax rate of 26.135%)		16,647			12,836			6,414			25,820			19,396

Efficiency ratio denominator		(129,124	)		436,591			215,991			801,456			586,532
Certain noninterest income items (non-GAAP)
Loss on early extinguishment of debt		570			—			—			—			—
(Gain) loss on sale of securities		801,492			—			—			28,393			28,393

Adjusted efficiency ratio denominator	$	672,938		$	436,591		$	215,991		$	829,849		$	614,925

Efficiency ratio⁽¹⁾		-329.30	%		64.86	%		66.94	%		69.57	%		71.00	%

Adjusted efficiency ratio (non-GAAP)⁽¹⁾		60.90	%		62.62	%		64.75	%		64.56	%		65.14	%

(1)

(2)

Actual tax rate of 21.946% on 2025 loss on sale of securities. Effective rate of 26.135% on all other items.

Page 14

Nasdaq SFNC Exhibit 99.2 rd 3 Quarter 2025 Earnings Presentation October 16, 2025

Company Overview Simmons First National Corporation A Mid-South based financial holding company serving our $24.2 $19.8 customers and the communities where we work and live since 1903 BILLION BILLION TOTAL ASSETS TOTAL DEPOSITS $9.3 $17.2 CONSECUTIVE YEARS 3 116 PAYING DIVIDENDS BILLION BILLION ASSETS UNDER TOTAL LOANS MANAGEMENT/ ADMINISTRATION YEARS OF SERVICE 122 15.07% 8.53% 1 TOTAL RBC RATIO TCE RATIO FINANCIAL CENTERS 223 ACROSS SIX STATES 4.6% 87% 2 DIVIDEND YIELD LOAN TO DEPOSIT RATIO 1.50% 168% ACL TO TOTAL NPL COVERAGE LOANS RATIO Figures presented on this slide are as of September 30, 2025, unless otherwise noted 2 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliations 2 Based on October 9, 2025, closing stock price of $19.06 and annualized dividend rate of $0.85 per share 3 The future payment of dividends is not guaranteed and is subject to various factors, including approval by the Company’s board of directors

3Q25 Financial Highlights 3

3Q25 Highlights 1 Reported Adjusted LQ Change 1 Net income $(562.8)M $64.9M 16% ❑ Completed Balance Sheet Repositioning ─ Net proceeds from common equity offering of ~$327M 1 EPS (diluted) $(4.00) $0.46 5% ─ Sold securities with a fair market value of ~$2.4B; after-tax loss of ~$626M ─ Proceeds from securities sale primarily used to deleverage the balance sheet by paying down higher cost deposits and wholesale borrowings 1 ROAA (8.96)% 1.03% 19 bps ❑ Strong-top-line growth 1 1 1 ─ Adjusted total revenue up 9% and adjusted PPNR up 20% Revenue $(569.5)M $232.5M 9% ─ Net interest margin at 3.50%, up 44 bps 1 1 1 ─ Adjusted efficiency ratio improves 280 bps PPNR $(711.6)M $92.8M 20% ─ Total loans at $17.2B, up 2% on a linked quarter annualized basis ─ Deleveraging drives decline in total deposits while improving deposit mix and NIM 3.50% 44 bps costs ❑ Credit quality metrics remain sound NCO ratio 25 bps - ─ Net charge-offs at 25 bps; provision expense exceeded net charge-offs by $4.5M ─ ACL ratio ends 3Q25 at 1.50%, up 2 bps ACL ratio 1.50% 2 bps ❑ Strong capital position 1 ─ TCE ratio at 8.5%, up 7 bps linked quarter NPL/Loans 90 bps (2) bps ─ Total risk-based capital ratio at 15.1%, up 65 bps 1 TCE ratio 8.5% 7 bps Comparisons on this page are 3Q25 vs 2Q25, unless otherwise noted Bps = basis points LQ = linked quarter (3Q25 vs 2Q25) 4 LQ Change – represents 3Q25 results vs 2Q25 results (provided that for the Net Income, EPS, ROAA, Revenue, and PPNR lines, represents 3Q25 adjusted results vs 2Q25 adjusted results) 1 Non-GAAP measures that management believes aid in the discussion of results. See Appendix for Non-GAAP reconciliations

Run-rate performance exceeds balance sheet repositioning guidance across the board Repositioning Reported Sept-25 Commentary 4 3 Guidance 3Q25 Run-Rate ❑ 3Q results reflect a partial impact from balance sheet repositioning 1 ❑ Sept-25 run-rate outperforms initial guidance Net Interest Margin (FTE) 3.50% 3.50% 3.76% from balance sheet repositioning ❑ Expect 4Q25 NIM to be 3.65%+ Net Interest Income (% growth) 10% 9% 13% ▪ Assumes full impact of September rate cut and an additional 25 bps cut in October ▪ Continued positive fixed rate loan repricing ▪ Full quarter impact of hedging program 2 Pre-Provision Net Revenue (% growth) 21% 20% 25% 2 Adjusted ROAA 1.10% 1.03% 1.15% 2 Adjusted ROTCE 14.0% 13.6% 14.9% CET1 Ratio 11.5% 11.5% Total Risk-Based Capital Ratio 13.5% 15.1% Sustainable performance in all key financial metrics with upside potential from strategic initiatives 1 Net interest margin (NIM) is presented on a fully taxable equivalent (FTE) basis using an effective tax rate of 26.135% 2 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliations 5 3 Sept-25 run rate reflects month of September results and is presented for informational purposes only. Percentage growth rates have been quarterized, are not guarantees of future performance, and may not reflect actual results for any full quarterly or annual period 4 Issued by the Company as of September 9, 2025, and not subsequently updated. Presented here for historical informational purposes only

Income Statement Highlights 2 2 Net Interest Income Adjusted Total Revenue Adjusted PPNR $ in millions $ in millions $ in millions $232.5 +9% $92.8 $186.7 +20% +9% $214.2 $77.3 $209.6 $208.5 $203.2 $171.8 $69.2 $66.4 $66.0 $164.9 $163.4 $157.7 3Q24 4Q24 1Q25 2Q25 3Q25 3Q24 4Q24 1Q25 2Q25 3Q25 3Q24 4Q24 1Q25 2Q25 3Q25 1 NIM 2.74% 3.06% 3.50% 2.87% 2.95% 2 2 2 Adjusted NIE Adjusted Net Income Adjusted Diluted EPS $ in millions $ in millions +5% +16% $64.9 $143.6 $0.46 $0.44 $56.1 $0.39 $139.7 $49.6 $0.37 $139.3 $46.0 $136.8 $136.8 $33.1 $0.26 3Q24 4Q24 1Q25 2Q25 3Q25 3Q24 4Q24 1Q25 2Q25 3Q25 3Q24 4Q24 1Q25 2Q25 3Q25 PPNR – Pre-provision net revenue NIE – Noninterest Expense 6 EPS – Earnings per Share 1 Net interest margin (NIM) is presented on a fully taxable equivalent (FTE) basis using an effective tax rate of 26.135% 2 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliations

Net Interest Margin (FTE) 1 2 1 Net Interest Margin Deleveraging Evolution Net Interest Margin Evolution FTE (%) $ in billions; Average Balances FTE 2Q25 July-25 Aug-25 Sept-25 3 bps +76 bps 3.50% 4 bps 1 38 bps 3.06% 3.18% 3.62% 3.76% NIM (1) bps 3.50% $24.0 3.06% $20.0 26% 24% 3.06% 2.95% +44 bps 16% 16% 2.87% 2.74% $16.0 $12.0 Loan Funding 2Q25 BS Other 3Q25 Yield Rate 73% 74% 81% 82% Repositioning $8.0 3Q24 4Q24 1Q25 2Q25 3Q25 Balance … Funding Rate NIM - 4Q24 NIM - 4Q24 Loan Yield Other $4.0 $- Commentary (3Q25 vs 2Q25) $(4.0) Select Yields/Rates th ❑ 6 consecutive quarter of NIM expansion; 3Q25 NIM FTE (%) expansion primarily due to balance sheet repositioning $(8.0) 6.44 6.32 6.26 6.31 86% 87% 82% 6.20 81% 1 ❑ Expect 4Q25 NIM to be 3.65%+ $(12.0) ❑ Focused on maintaining loan pricing discipline and $(16.0) continued proactive deposit pricing management 4.01 3.63 3.54 3.48 3.48 ▪ 5 bps increase in loan yields 10% 12% $(20.0) 17%▪ 11 bps decrease in deposit costs 17% 3% ▪ Fixed-rate asset repricing remains a tailwind 2% 2.79 2.60 1% 2.44 $(24.0) 2.36 2% 2.25 ❑ Swap income of $7.5 million in 3Q25 compared to $8.1 3Q24 4Q24 1Q25 2Q25 3Q25 Customer deposits Wholesale funding Subordinated debt million in 2Q25 Loan Yield (FTE) Securities (FTE) Cost of Deposits Loans Securities Other earning assets 1 Net interest margin (NIM) is presented on a fully taxable equivalent (FTE) basis using an effective tax rate of 26.135% 2 Percentages in the NIM and Deleveraging Evolution graph represent average loans, securities and other earning assets as a percentage of total average earnings assets, and average customer deposits, and wholesale funding (brokered deposits and FHLB/other borrowings) as a 7 percentage of average interest bearing liabilities FTE – Fully taxable equivalent using an effective tax rate of 26.135% BS – Balance Sheet

Noninterest Income 3Q25 Adjusted 3Q25 vs Adjusted 1 $ in millions 2Q25 3Q24 Reported Adjusted Commentary Service charges on deposit accounts $ 13.0 $ 13.0 $ 0.5 4 % $ 0.3 3 % ❑ Continued focus on driving growth along major fee-based businesses results in 3Q25 fee Wealth management fees 10.0 10.0 0. 5 5 0.9 10 income at top end of management expectations Debit and credit card fees 8.5 8.5 ( 0.1) ( 1) 0.3 4 ❑ Increase in service charges on deposit accounts Mortgage lending income 2.3 2.3 0. 6 34 0.3 15 reflects growth in consumer accounts and performance in commercial treasury Bank owned life insurance 3. 9 3.9 0. 1 1 0.2 5 management Swap fee income 0.9 0.9 0. 1 9 0.2 24 ❑ Linked quarter increase in “Other” noninterest income primarily driven by negative SBIC Other service charges and fees 1. 5 1.5 0. 2 12 - (2) valuation adjustments in 2Q25 Other 5.2 5.8 1.8 45 (1.8) (24) ❑ Sold ~$2.4 billion of securities (fair value) for a pre-tax loss of ~$801.5 million or ~$626 million 45.3 45.9 3.5 8 0.4 1 after-tax loss Gain (loss) on sale of securities (pre-tax) (801.5) - - - - - Total noninterest income $(756.2) $ 45.9 $ 3.5 8 % $ 0.4 1 % 1 Adjusted Total Revenue Per Employee Adjusted Noninterest Income Adjusted PPNR per Avg. Diluted Share 1 1 (FTE) to Adjusted Total Revenue ($ in thousands) +8% $0.66 22.4% $80.7 22.0% $0.61 20.9% $72.7 $71.1 19.7% $70.8 19.8% $68.4 $0.55 $0.53 $0.52 3Q24 4Q24 1Q25 2Q25 3Q25 3Q24 4Q24 1Q25 2Q25 3Q25 3Q24 4Q24 1Q25 2Q25 3Q25 Totals may not foot due to rounding FTE – Full-time equivalent 8 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliations

Noninterest Expense 3Q25 Adjusted 3Q25 vs Adjusted Commentary 1 $ in millions Reported 2Q25 3Q24 Adjusted ❑ 3Q25 noninterest expense at top end of management expectations Salaries and employee benefits $ 76.2 $ 75.9 $ 3.7 5 % $ 6.8 10 % ▪ Full-year expenses projected to beat previously issued Occupancy expense, net 12.1 1 1.7 0.2 2 ( 0.3) (3) 2% growth guidance while absorbing 1Q25 fraud event Furniture and equipment 5.3 5.3 (0.2) ( 4) (0.4) (6) ❑ Linked quarter increase in salaries and employee benefits primarily reflects YTD accrual true-ups Deposit insurance 5.2 5.2 0.3 5 (0.4) (7) ❑ “Other” noninterest expense improved linked OREO and foreclosure expense 0.2 0.2 - ( 7) 0.1 130 quarter due to $1.6 million fraud recovery in 3Q25 Other 43.0 41.5 ( 1.1) ( 2) (2.9) (7) ❑ Adjusted efficiency ratio improves 280 bps on a linked quarter basis Total noninterest expense $142.0 $139.7 $ 2.9 2 % $ 2.9 2 % 1 Adjusted Efficiency Ratio Employees (FTE) # of Financial Centers 280 bps 234 2,972 64.75% 2,949 2,947 improvement 2,946 63.38% 62.89% 2,883 223 223 222 222 60.52% 57.72% 3Q24 4Q24 1Q25 2Q25 3Q25 3Q24 4Q24 1Q25 2Q25 3Q25 3Q24 4Q24 1Q25 2Q25 3Q25 Note: Numbers may not add due to rounding FTE – full-time equivalent 9 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliations

Deposits, Securities, Liquidity, Interest Rate Sensitivity and Capital 10

Deposits Decline in total deposits reflects reduction of higher Deposit Mix As a Percentage of Total Deposits rate, non-relationship wholesale and public fund $ in billions; Period End Balances Period End Balances 2Q25 3Q25 deposits as part of balance sheet repositioning $21.9 $21.9 $21.7 $21.8 Noninterest bearing 20.5% 22.1% $19.8 $3.4 $3.3 $2.9 $3.2 $1.8 $2.7 $2.8 $3.0 $2.7 $2.2 Interest bearing transaction accounts 39.0% 42.8% $2.9 $2.9 $3.3 $3.1 $3.0 Time deposits 13.4% 14.7% $8.5 $8.0 $8.2 $8.3 $8.5 $4.5 $4.5 $4.5 $4.5 $4.4 Public funds (interest bearing) 12.3% 11.1% 3Q24 4Q24 1Q25 2Q25 3Q25 Noninterest Bearing Interest Bearing Transaction Accounts Time Deposits Public Funds (interest bearing) Brokered Deposits Customer deposits 85.2% 90.7% 65% interest bearing Evolution of Funding Rates 1 deposit beta since 2Q24 Brokered deposits 14.8% 9.3% Interest Bearing Deposits Cost of Deposits 5.33% 5.33% 5.33% 5.26% 5.27% Avg Fed Funds Rate 4.99% 4.66% 4.52% 4.33% 4.33% 4.30% Commentary 3.65% 3.53% 3.52% 3.48% 3.31% 3.28% 3.06% 3.05%❑ Balance sheet repositioning results in improved mix of deposits 2.97% 2.86% 2.57% 2.10%▪ Noninterest bearing deposits represent 22.1% of total deposits 2.79% 2.79% 2.75% ▪ Lower cost interest bearing transaction accounts represent 42.8% of total deposits 2.58% 2.60% 1.41% 2.44% 2.37% 2.36% 2.25% 1.96% ❑ 11 basis point decrease in cost of deposits on a linked quarter basis 1.58% 1.02% ❑ Focus remains on optimizing deposit balances and proactively managing costs 2Q22 3Q22 4Q22 1Q23 2Q23 3Q23 4Q23 1Q24 2Q24 3Q24 4Q24 1Q25 2Q25 3Q25 ❑ ~77% of deposits are FDIC insured or are collateralized deposits Source: Average Fed Funds rate based on data from www.macrotrends.net 1 Deposit beta calculated as change in cost of deposits from 2Q24 to 3Q25 divided by the change in quarterly average Federal Funds Effective rate for 2Q24 vs 3Q25 11

Securities and Liquidity 2 Securities Portfolio Summary Securities Portfolio Bond Ratings Securities Portfolio by Type $ in millions 5% 2% 1 Yield (FTE) Effective Duration At September 30, 2025 At September 30, 2025 AFS 25% AFS AFS Fixed Rate U.S. Guaranteed/GSE $2,508 Municipal 3.34% 13.02 Aaa/AAA 406 MBS/CMO 2.61 5.33 Aa/AA 656 Treasury/Agency 3.71 0.64 A 88 Corporate 5.97 0.97 Baa/BBB 133 Other 2.46 8.29 68% Not Rated 10 Variable Rate 4.68 - Treasury/Agency States and Political Subdivisions Total $3,801 MBS/CMO Corporate & Other Total 3.23% 6.31 Additional Liquidity Sources Wholesale Funding $ in millions $ in millions September 30, Change vs FHLB borrowing availability $ 6,134 2025 2Q25 Unpledged securities 1,575 Brokered deposits $1,841 $(1,396) Fed Funds lines and Fed Discount Window 1,824 FF purchased/securities sold 22 (9) FHLB advances 3 (615) Other 16 - Total at 9.30.25 $9,533 Total $1,882 $(2,020) 3 Uninsured, non-collateralized deposits $4,459 Wholesale Funding / Total Funding = 9.5% Coverage ratio 2.1x FTE – fully taxable equivalent using an effective tax rate of 26.135% Data presented on this slide is as of September 30, 2025, unless otherwise noted 12 1 Effective yield of securities portfolio at 9/30/25 2 Bond ratings reflect highest rating by Moody's Investors Service, Inc., Standard & Poor's or Fitch Ratings 3 Uninsured, non-collateralized deposits represent uninsured deposits of Simmons Bank, less the uninsured portion of collateralized deposits, and deposit balances of SFNC subsidiaries. See appendix for Non-GAAP reconciliations

Interest Rate Sensitivity Loan Portfolio – Repricing and Maturity (contractual) CD Maturities (over the next 12 months) At September 30, 2025 $ in millions In millions Repricing Term Rate Structure Weighted Average Rates 3 mo 3-12 1-3 3-5 Over 5 Total Variable Fixed 3.72% 4.36% 3.58% 4.12% 3.30% 4.24% 3.04% or less mo years years years RE - Construction $ 2,412.5 $ 143.7 $ 235.8 $ 73.8 $ 9.0 $ 2,874.8 $ 2,316.4 $ 558.4 RE - Commercial 3,158.3 912.7 2,477.6 707.2 619.9 7,875.7 3,349.9 4,525.8 $1,455.3 RE - Single-Family 634.2 287.4 597.1 394.3 704.8 2,617.8 1,429.5 1,188.3 $1,001.9 $830.9 Commercial 1,535.8 96.1 399.8 260.2 105.4 2,397.4 1,573.2 824.2 $337.4 Consumer 215.0 11.9 40.3 10.1 8.0 285.4 207.4 78.0 $264.6 $214.6 $101.3 1 Other 733.7 32.3 48.0 41.1 282.8 1,137.8 723.3 414.5 4Q25 1Q26 2Q26 3Q26 Total $ 8,689.5 $ 1,484.1 $ 3,798.6 $ 1,486.7 $ 1,729.9 $ 17,188.8 $ 9,599.7 $ 7,589.1 Customer CDs Brokered CDs 2 7.16% 5.34% 5.46% 6.16% 4.69% 6.26% 6.95% 5.44% Weighted average rate Note: Weighted average rates in the table above are based on contractual repricing and maturity. Does not include the impact of Hedging Program summarized on Slide 14 Balance Sheet Interest Rate Sensitivity Over the next 12 months (estimated) Additional Interest Rate Sensitivity Factors Change in Interest Rates % Impact on Net Interest Income 3 ❑ ~$100 million of projected securities principal maturities per quarter 4 ❑ ~$2.3 billion of projected cash flows from fixed rate loans at a weighted average rate of 5.75% Down 25 bps (0.5)% 5 ❑ ~29% of customer interest bearing deposits are tied to index rates, principally Fed Funds target rate Down 50 bps (0.9)% ❑ $1.625 billion Hedging Program summarized on slide 14 Down 75 bps (1.2)% Assumes a gradual change in interest rates and static balance sheet as of September 30, 2025. Interest rate cuts are assumed in October 2025, December 2025 and April 2026 Totals may not add due to rounding 1 Other includes agriculture, mortgage warehouse and other loans 13 2 Weighted average rates do not include mortgage warehouse and credit card portfolios 3 Projections over the next 12 months assuming a static balance sheet as of September 30, 2025 4 Cash flows from fixed rate loans over the next 12 months includes prepayment assumptions and are based on the forward rate curve 5 Customer interest bearing deposits includes savings, money market, checking and customer CDs. Does not include brokered deposits

Hedging Program 1 Estimated Future Swap Income Hedging Program Strategy $ in millions; Based on forward rates ❑ Net interest income (NII) sensitivity moved from liability sensitive to asset sensitive post balance sheet $6.2 restructure $5.7 $5.3 $5.1 $5.0 ❑ Evolved 3Q25 hedging strategy to protect NII from falling rates ❑ Executed $1.625 billion of interest rate swaps in 3Q25 to reduce negative impact of falling rates by ~50% resulting in near neutral IRR position ▪ Added $1.0 billion combination spot and forward starting receive fixed swaps to hedge variable rate loans ▪ Added $300 million combination spot and forward starting receive fixed swaps to hedge variable rate CMBS ▪ Added $325 million combination spot and forward starting receive fixed swaps to hedge recently issued fixed rate subordinated debt 4Q25 1Q26 2Q26 3Q26 4Q26 Quarterly Average (Notional) Annual Average (Notional) Hedged Item Quarter Initiated Rate Protection 3Q25 4Q25 1Q26 2Q26 3Q26 4Q26 2027 2028 2029 2030 Variable rate loans 3Q25 Down rate $ 573.4 $ 1,000.0 $ 1,000.0 $ 1,000.0 $ 1,000.0 $ 1,000.0 $ 1,000.0 $ 899.6 $ 209.6 $ - Varibale rate CMBS 3Q25 Down rate 117.4 300.0 300.0 300.0 260.9 200.0 130.4 - - - Subordinated debt 3Q25 Down rate 67.1 325.0 325.0 325.0 325.0 325.0 325.0 325.0 325.0 244.0 Fixed rate munis 3Q21 Up rate 1,001.7 1,001.7 1,001.7 1,001.7 1,001.7 1,001.7 1,001.7 937.2 54.2 - Net Asset Swap Position (up rate - down rate) $ ( 243.8) $ 623.3 $ 623.3 $ 623.3 $ 584.2 $ 523.3 $ 453.7 $ 287.4 $ 480.4 $ 244.0 Quarterly Fixed Rate Annual Fixed Rate Hedged Item Receive Pay 3Q25 4Q25 1Q26 2Q26 3Q26 4Q26 2027 2028 2029 2030 Variable rate loans Fixed 1M SOFR 4.03% 4.03% 3.59% 3.24% 3.24% 3.24% 3.24% 3.26% 3.22% - Varibale rate CMBS Fixed 1M SOFR 3.82% 3.82% 3.82% 3.82% 3.53% 3.07% 3.07% - - - Subordinated debt Fixed SOFR 30D average 3.56% 3.56% 3.56% 3.56% 3.56% 3.07% 3.07% 3.07% 3.07% 3.07% Fixed rate munis Fed effective Fixed 1.21% 1.21% 1.21% 1.21% 1.21% 1.21% 1.21% 1.22% 1.22% - Totals may not add due to rounding 1 Estimated swap income based on projected forward effective fed funds rates as of September 30, 2025. Does not include potential impact of hedge ineffectiveness that is recorded in interest income. 14

3 Capital: Economic Capital improves across the board following balance sheet repositioning 1 1 CET 1 Capital Ratio Tier 1 Leverage Ratio 12.4% 10.0% 11.5% 9.6% Capital Ratios (at 9/30/25) 9.9% 8.2% CET 1 Capital Ratio Total Risk-Based Capital Ratio Adj. HTM Reported 15.1% 2,3 11.5% Loss 2 Equity to Assets Tangible Common Equity Ratio 2Q25 3Q25 13.9% 8.5% 2Q25 3Q25 WELL CAPITALIZED WELL CAPITALIZED 5.0% 6.5% 1 1 Total Risk-Based Capital Ratio Tier 1 Risk-Based Capital Ratio Subordinated Debt 15.1% $37M of subordinated debt due 2030 redeemed and paid in full on July 31, 2025 14.4% 12.4% 11.5% $330M of subordinated debt due 2028 redeemed and paid in full on October 1, 2025 12.0% 9.9% $325M of subordinated debt due 2035 issued during 3Q25. See slide 14 for more information on the hedging instrument that converts the debt from fixed rate to floating rate Current Term/Structure Maturity Date Call Date Amount Coupon 10 yr NC 5 10/1/2035 10/1/2030 $325M 6.25% 2Q25 3Q25 2Q25 3Q25 WELL CAPITALIZED WELL CAPITALIZED 8.0% 10.0% 1 3Q25 data as of September 30, 2025, 2Q25 data as of June 30, 2025, and 3Q24 data as of September 30, 2024 2 Non-GAAP measures that management believes aid in the discussion of results. See Appendix for Non-GAAP reconciliations 15 3 Economic Capital Inclusive of after-tax loss from transfer of HTM portfolio to AFS of ~$501 million

Loan Portfolio 16

Loans: Well-diversified, granular portfolio and conservative credit culture Loan Portfolio Waterfall Linked Quarter Change by Loan Type $ in millions $ in millions Total Loans $78 $2,113 RE – Commercial $(85) $136 $17,189 $17,111 RE – Construction $(2,171) $90 1 Funded loans Paydowns/ Other 2 Commercial $(39) /advances payoffs RE – Single Family $(8) Consumer & Other $(16) Agricultural $20 Mortgage Warehouse $120 Total loans Total loans 3 Run-Off Portfolio $(4) at 6/30/25 at 9/30/25 Unfunded Commitments $ in millions Commentary RE - Construction Commercial RE - Single Family RE - Commercial Agriculture Consumer/Other ❑ Well-diversified, granular portfolio with no significant industry or geographic concentrations $3,947 $3,888 $3,955 $3,739 $3,681 ❑ Total loans at $17.2 billion, up 2% on a linked quarter annualized basis 94% variable rate❑ Unfunded commitments increased for 4th consecutive quarter • 62% tied to Prime ❑ Minimal exposure to Shared National Credits (SNC) • 38% tied to SOFR ▪ SNC totaled ~1% of total loans ▪ Additional banking relationships with all borrowers 3Q24 4Q24 1Q25 2Q25 3Q25 1 “Other” includes linked quarter change associated with loan portfolios impacted by seasonality (agricultural, mortgage warehouse and credit cards) and change in run-off portfolio 2 Commercial loan change excludes the impact of loans included in the run-off portfolio 17 3 “Run-off portfolio” consists of small ticket equipment finance and acquired asset based lending portfolios

Pipelines: Represent opportunities that meet disciplined appetite for credit and pricing Commercial Loan Pipeline by Category $ in millions Opportunity Proposal Ready to Close $1,815 $1,631 $1,611 Commentary $757 $1,265 $490 ❑ Continued focus on maintaining prudent underwriting $1,244 $564 standards and pricing discipline $1,013 $1,002 $552 $549 ❑ $490 million of ready to close loans in the commercial $249 $292 $436 1 $330 $381 pipeline as of September 30, 2025, with a rate of 7.19% $121 $168 $199 $147 ❑ Mortgage loan originations in 3Q25 ❑ 80% purchase ❑ 20% refinance $485 $551 $527 $514 $809 $775 $685 1Q24 2Q24 3Q24 4Q24 1Q25 2Q25 3Q25 Rate Ready to 8.38% 8.68% 8.31% 7.93% 7.39% 7.35% 7.19% 1 Close Mortgage Loan Volume $ in millions Mortgage Closed Loan Volume Mortgage Pipeline Volume $31 $25 $27 $27 $29 $32 $16 $111 $110 $96 $89 $78 $75 $69 1Q24 2Q24 3Q24 4Q24 1Q25 2Q25 3Q25 1 Rate ready to close represents the weighted average rate on commercial loans that are ready to close and does not include fees, including FAS 91 fees, associated with those commercial loans 18

Loans: Conservative LTVs underpin prudent underwriting standards in key sectors Office (non-owner occupied permanent) Key Statistics At 9/30/25 Loan Portfolio – Geographic diversification By State By State NPL Ratio 0.00% 16% Past Due 30+ Days 0.00% 2% 2% 20% Average Loan Size $2.2M 46% 33% 8% Median Loan Size $0.5M $0.7B 2% Number of Loans <$1M 63% 13% 4% 1 Average LTV 46.7% $16.6B 13% Weighted Average LTV 54.4% 9% Texas Arkansas Tennessee Missouri Oklahoma Kansas Other Multifamily (permanent) Key Statistics At 9/30/25 19% 13% By State 11% NPL Ratio 0.87% Texas Arkansas Tennessee Missouri 10% 38% Past Due 30+ Days 0.00% Oklahoma Kansas Other 5% Average Loan Size $3.0M $0.9B 5% Median Loan Size $0.6M % of Total % of Total Top 10 MSAs Number of Loans <$1M 65% 1 1 Loans Commitments 14% 17% Average LTV 51.3% Dallas-Plano-Irving 9.3% 9.1% Texas Arkansas Tennessee Missouri Oklahoma Kansas Other Weighted Average LTV 61.0% Houston-Sugarland-Baytown 9.2% 8.7% Little Rock-North Little Rock-Conway 6.0% 6.7% Retail (non-owner occupied permanent) Key Statistics At 9/30/25 Nashville-Davidson-Murfreesboro 4.9% 5.6% By State NPL Ratio 0.20% 15% Memphis 4.8% 4.7% 1% Past Due 30+ Days 0.02% Fort Worth-Arlington 4.0% 4.0% 5% 47% Average Loan Size $1.8M Fayetteville-Springdale-Rogers 3.3% 3.1% 7% $0.9B Median Loan Size $1.0M St. Louis 2.6% 2.4% Number of Loans <$1M 51% 10% Kansas City 2.2% 2.5% Average LTV 47.8% Jonesboro 2.2% 2.0% 15% Weighted Average LTV 55.5% Texas Arkansas Tennessee Missouri Oklahoma Kansas Other Data shown above as of September 30, 2025 1 Total loans or commitments excluding credit card portfolio and mortgage warehouse 19

CLD: Quick recycling of capital given short duration of portfolio Construction and Land Development (CLD) By State % of Total % of Total Key Statistics At 9/30/25 Top 10 MSAs Loans Commitments NPL Ratio 0.32% Dallas-Plano-Irving 10.6% 10.7% Past Due 30+ Days 0.01% 27% Nashville-Davidson-Murfreesboro 9.0% 10.1% 43% Average Loan Size $1.4M Houston-Sugarland-Baytown 8.7% 8.3% Median Loan Size $0.3M Memphis 6.1% 5.3% $2.9B Number of Loans <$1M 83% 2% Little Rock-North Little Rock-Conway 5.6% 4.9% 2% Average LTV 56.0% Fort Worth-Arlington 4.1% 4.4% 4% Weighted Average LTV 52.7% Corpus Christi 3.0% 2.5% Weighted Average Maturity ~20 months 13% 9% Fayetteville-Springdale-Rogers 2.7% 2.6% Texas Arkansas Tennessee Missouri Orlando-Kissimmee-Sanford 2.5% 2.6% Oklahoma Kansas Other Phoenix-Mesa-Glendale 1.7% 3.8% CLD - Industrial Warehouse (non-owner occupied) CLD - Multifamily By State By State Key Statistics At 9/30/25 Key Statistics At 9/30/25 NPL Ratio 0.00% 14% NPL Ratio 0.00% Texas 24% Texas Past Due 30+ Days 0.00% Past Due 30+ Days 0.00% 44% Arkansas Tennessee 17% 45% Average Loan Size $19.1M Average Loan Size $11.9M Tennessee Missouri $0.8B $0.6B Median Loan Size $19.1M 5% Median Loan Size $7.6M Kansas Florida 5% Number of Loans <$1M 26% Number of Loans <$1M 35% Florida Other 6% Average LTV 48.1% 17% Average LTV 37.5% Other 7% 16% Weighted Average LTV 49.1% Weighted Average LTV 43.9% Weighted Average Maturity ~14 months Weighted Average Maturity ~12 months Data shown above as of September 30, 2025 20

Loans: Loan portfolio by type and key credit metrics as of June 30, 2025 as of September 30, 2025 % of % of Past Due 30+ Unfunded Unfunded Balance Total Balance Total Days Classified Nonperforming Commitment ACL Commitment $ in millions $ Loans $ Loans $ $ $ $ % Reserve Total Loan Portfolio Credit Card 176 1% 173 1% 2 1 1 - 3.46% - Consumer – Other 124 1% 112 1% 1 - - 32 3.11% 0.76% Real Estate – Construction 2,785 16% 2,875 17% - 12 9 1,826 1.45% 1.05% Real Estate – Commercial 7,961 47% 7,876 46% 2 336 81 302 1.58% 0.37% Real Estate - Single-family 2,626 15% 2,618 15% 12 37 31 308 1.61% 0.88% Commercial 2,440 14% 2,397 14% 3 52 30 1,373 1.45% 0.16% Mortgage Warehouse 324 2% 444 2% - - - - 0.20% - Agriculture 333 2% 353 2% - 2 1 114 0.61% 0.13% Other 342 2% 341 2% - 1 1 - 0.75% 5.74% Total Loan Portfolio 17,111 100% 17,189 100% 20 441 154 3,955 1.50% 0.65% Loan Concentration (Holding Company Level) C&D 94% 96% CRE 268% 268% Select Loan Categories Retail 1,164 7% 1,158 7% - 4 2 110 0.99% 0.76% Nursing / Extended Care 231 1% 229 1% 1 108 - 1 7.48% 0.03% Healthcare 586 3% 554 3% - 21 3 98 1.21% 0.14% Multifamily 1,852 11% 1,734 10% - 33 8 490 1.33% 0.25% Hotel 698 4% 697 4% - 60 27 158 3.79% 1.58% Restaurant 603 4% 611 4% - 36 28 26 3.60% 0.46% NOO Office 782 5% 808 5% - 20 8 106 2.43% 0.82% NOO Industrial Warehouse 1,371 8% 1,444 8% - 19 - 400 0.34% 0.14% 1 Run-Off Portfolio 47 <1% 43 <1% 1 4 3 1 6.50% - 1 “Run-off portfolio” consists of small ticket equipment finance and acquired asset based lending portfolios 21

Credit Quality 22

Credit Quality: Nonperforming and past due loans Nonperforming Loans Nonperforming Loans Evolution $ in millions $ in millions $157.2 $153.9 $152.4 $3.9 $49.6 $49.3 $49.8 $157.2 $110.8 $101.7 $(3.5) $5.5 $(0.7) $0.6 $3.5 $153.9 $3.3 $3.8 $7.4 $(0.2) $(3.1) $(0.3) $105.3 $104.1 $101.3 $98.8 $94.3 RE – Run-Off Two Specific 2Q25 RE - RE - Commercial Consumer & 3Q25 3Q24 4Q24 1Q25 2Q25 3Q25 3 1 Construction Commercial Single Family Other Portfolio Credit 2 Core Portfolio Run-Off Portfolio1 Two Specific Credit Relationships2 Relationships 4 4 4 Past Due 30-89 days / Total Loans Nonperforming Loans / Total Loans Nonperforming Assets / Total Assets Strategic decision to de-risk certain elements of the loan portfolio through the planned exit of particular acquired non- relationship credits Annual Annual Quarterly Annual Quarterly Quarterly 0.96% 0.66% 0.92% 0.64% 0.90% 0.89% 0.62% 0.61% 0.55% 0.65% 0.65% 0.45% 0.45% 0.59% 0.57% 0.38% 0.50% 0.33% 0.65% 0.31% 0.44% 0.63% 0.46% 0.42% 0.60% 0.61% 0.24% 0.22% 0.21% 0.24% 0.22% 0.21% 0.20% 0.17% 0.37% 0.11% 0.11% 0.23% 0.18% NPL Ratio NPL Ratio, excluding Two Specific Credit Relationships5 NPA to Assets NPA to Assets, excluding Two Specific Credit Relationships5 2019 2020 2021 2022 2023 2024 3Q24 4Q24 1Q25 2Q25 3Q25 2019 2020 2021 2022 2023 2024 3Q24 4Q24 1Q25 2Q25 3Q25 2019 2020 2021 2022 2023 2024 3Q24 4Q24 1Q25 2Q25 3Q25 Source: S&P Global Market Intelligence 2019 – 2024; Company Reports 1 “Run-off portfolio” consists of small ticket equipment finance and acquired asset based lending portfolios 2 For purposes of the slides in this presentation, “Two Specific Credit Relationships” refers to the two largest nonperforming loans as of September 30, 2025 3 Consumer & Other includes credit card, consumer-other, mortgage warehouse, agriculture and other loan portfolios 23 4 As of December 31, for each respective year shown above; quarterly data as of the end of the quarter for each respective period 5 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliations

ACL: Loan loss provision and net charge-offs Loan Loss Provision and Net Charge-Off Ratio Credit Quality Commentary $ in millions $40.0 0.40% ❑ Underlying credit metrics remain healthy 0.27% 0.25% ▪ 11 bps of loans past due 30-89 days, down 6 bps from 2Q25 levels 0.30% 0.25% $35.0 0.23% 0.22% 1 ▪ 61 bps NPL ratio excluding Two Specific Credit Relationships 0.20% $30.0 $26.8 ▪ Two Specific Credit Relationships represent 54% of our Top 10 NPLs 0.10% $25.0 0.00% ❑ NCO ratio of 25 bps in 3Q25; provision expense exceeded net charge-offs $20.0 $15.0 ❑ ACL to total loans ended 3Q25 at 1.50%, up from 1.48% at 2Q25 -0.10% $15.2 $15.0 $13.3 $12.1 $11.9 -0.20% $4.5 $1.8 $1.4 $2.8 $2.2 $10.0 ACL METHODOLOGY AS OF 9/30/25 -0.30% ▪ Moody’s Sept 2025 scenarios with management’s weighting: $11.5 $5.0 $10.6 $10.7 $9.3 $9.6 -0.40% Baseline (75%) / S1 (15%) / S3 (10%) ▪ Total credit coverage / total commitments: 1.34% $0.0 -0.50% 3Q24 4Q24 1Q25 2Q25 3Q25 ACL and ACL to Total Loans NCO Provision Incremental Provision Provision attributable to Two Specific Credit Relationships NCO Ratio $ in millions 1.75% $275.0 1.50% 1.48% 1.48% 1.55% 1.38% 1.35% 1.35% $250.0 $258.0 $253.5 $252.2 1.15% Reserve for Unfunded Commitments $235.0 $225.0 $233.2 0.95% As of As of As of As of As of $ in millions 9/30/24 12/31/24 3/31/25 6/30/25 9/30/25 0.75% $200.0 Unfunded Commitments $3,681 $3,739 $3,888 $3,947 $3,955 0.55% Reserve for Unfunded Commitments $25.6 $25.6 $25.6 $25.6 $25.6 0.35% $175.0 0.15% Provision for Unfunded Commitments - - - - - $150.0 -0.05% Reserve / Unfunded Balance 0.70% 0.69% 0.66% 0.65% 0.65% 3Q24 4Q24 1Q25 2Q25 3Q25 ACL ACL to Total Loans 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliations 24

Forward-Looking Statements and Non-GAAP Financial Measures Forward-Looking Statements. Certain statements by Simmons First National Corporation (the “Company”, which where appropriate includes the Company’s wholly-owned banking subsidiary, Simmons Bank) contained in this presentation may not be based on historical facts and should be considered forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements may be identified by reference to a future period(s) or by the use of forward-looking terminology, such as anticipate, “believe,” “continue,” estimate, expect, foresee,“ “indicate,” “plan,” “potential,” “project,” “target,” may, might, will, would, could,“ “should,” “likely” or intend, future or conditional verb tenses, and variations or negatives of such terms or by similar expressions. These forward-looking statements include, without limitation, statements relating to the Company’s future growth; business strategies; product development; revenue; expenses (including interest expense and non-interest expenses); assets; loan demand (including loan growth, loan capacity, and other lending activity); deposit levels; dividends; asset quality; profitability; earnings; critical accounting policies; net interest margin; noninterest income; the Company's common stock repurchase program; adequacy of the allowance for credit losses; income tax deductions; credit quality; level of credit losses from lending commitments; interest rate sensitivity (including, among other things, the potential impact of rising rates); loan loss experience; liquidity; capital resources; future economic conditions and market risk; interest rates; the Company’s securities portfolio; legal and regulatory limitations and compliance and competition; anticipated loan principal reductions; projections regarding loan repricing; the quarterized results for September 2025 set forth on slide 5; the net interest margin projection set forth on slides 5 and 7; the full-year expense commentary set forth on slide 9; the interest rate sensitivity estimates and projections set forth on slide 13; and the estimates related to the hedging program (including estimated future swap income) set forth on slide 14. Readers are cautioned not to place undue reliance on the forward-looking statements contained in this presentation in that actual results could differ materially from those indicated in or implied by such forward-looking statements due to a variety of factors. These factors include, but are not limited to, changes in the Company's operating or expansion strategy; the availability of and costs associated with obtaining adequate and timely sources of liquidity; changes in credit quality; changes in general market and economic conditions; increased unemployment; labor shortages; possible adverse rulings, judgments, fines, settlements and other outcomes of pending or future litigation; the ability of the Company to collect amounts due under loan agreements; significant increases in nonaccrual loan balances; changes in consumer preferences and loan demand; the effectiveness of the Company's interest rate risk management strategies; laws and regulations affecting financial institutions in general or relating to taxes; the effect of pending or future legislation; changes in governmental administrations; the ability of the Company to repurchase its common stock on favorable terms; the ability of the Company to successfully manage and implement its acquisition strategy and integrate acquired institutions; changes in tariff policies; difficulties and delays in integrating an acquired business or fully realizing cost savings and other benefits of mergers and acquisitions; changes in interest rates, deposit flows, real estate values, and capital markets; increased inflation; customer acceptance of the Company's products and services and changes in customer behaviors; changes or disruptions in technology and IT systems (including cyber or other information technology threats, attacks and events); changes in accounting principles relating to loan loss recognition (current expected credit losses, or CECL); fraud that results in material losses or that we have not discovered yet that may result in material losses; the benefits associated with the Company’s early retirement program; pandemics or significant health hazards, severe weather conditions, natural disasters, terrorist activities, political crises, war, and other military conflicts (including the ongoing military conflicts between Russia and Ukraine) or other major events, or the prospect of these events; increased competition in the markets in which the Company operates and from non-bank financial institutions; changes in governmental policies; the effects of a government shutdown; loss of key employees; reliance on third parties for key services; the soundness of other financial institutions and any indirect exposure related to the closings of other financial institutions and their impact on the broader market through other customers, suppliers and partners, or that the conditions which resulted in the liquidity concerns experienced by closed financial institutions may also adversely impact, directly or indirectly, other financial institutions and market participants with which the Company has commercial or deposit relationships; increased delinquency and foreclosure rates on commercial real estate and other loans; and other risk factors. Other relevant risk factors are detailed in the Company’s Form 10-K for the year ended December 31, 2024, the Company’s Form 10-Q for the quarter ended June 30, 2025, and other reports that the Company has filed with or furnished to the U.S. Securities and Exchange Commission (the SEC), all of which are available from the SEC on its website, www.sec.gov. In addition, there can be no guarantee that the board of directors (“Board”) of the Company will approve a quarterly dividend in future quarters, and the timing, payment, and amount of future dividends (if any) is subject to, among other things, the discretion of the Board and may differ significantly from past dividends. Any forward-looking statement speaks only as of the date of this presentation, and the Company undertakes no obligation to update these forward-looking statements to reflect events or circumstances that occur after the date of this presentation. Annualized, quarterized, pro forma, projected and estimated numbers are used for illustrative purpose only, are based on hypothetical assumptions that may not accurately reflect future incomes, are not forecasts and are not guaranteed and may differ significantly from actual results. Non-GAAP Financial Measures. This presentation contains financial information determined by methods other than in accordance with U.S. generally accepted accounting principles (“GAAP”). The Company’s management uses these non-GAAP financial measures in their analysis of the Company’s performance and capital adequacy. These measures adjust GAAP performance measures to, among other things, include the tax benefit associated with revenue items that are tax-exempt, as well as exclude from net income (including on a per share diluted basis), pre-tax, pre-provision earnings, net charge-offs, income available to common shareholders, non-interest income, and non-interest expense certain income and expense items attributable to, for example, loss on sale of securities, net branch right-sizing initiatives, early retirement program, termination of vendor and software services, and losses on early extinguishment of debt. In addition, the Company also presents certain figures based on tangible common stockholders’ equity, tangible assets and tangible book value, which exclude goodwill and other intangible assets, and presents certain other figures to include the effect that accumulated other comprehensive income could have on the Company’s capital levels. The Company further presents certain figures that are exclusive of the impact of deposits and/or loans acquired through acquisitions, mortgage warehouse loans, and/or energy loans, gains and/or losses on the sale of securities, or the Two Specific Credit Relationships. The Company’s management believes that these non-GAAP financial measures are useful to investors because they, among other things, present the results of the Company’s ongoing operations without the effect of mergers or other items not central to the Company’s ongoing business, present the Company’s capital inclusive of the potential impact of AOCI (primarily comprised of unrealized losses on securities), as well as normalize for tax effects and certain other effects. Management, therefore, believes presentations of these non-GAAP financial measures provide useful supplemental information that is essential to a proper understanding of the operating results of the Company’s ongoing businesses, and management uses these non-GAAP financial measures to assess the performance of the Company’s ongoing businesses as related to prior financial periods. These non-GAAP disclosures should not be viewed as a substitute for operating results determined in accordance with GAAP, nor are they necessarily comparable to non-GAAP performance measures that may be presented by other companies. Where non-GAAP financial measures are used, the comparable GAAP financial measure, as well as the reconciliation to the comparable GAAP financial measure, can be found in the appendix to this presentation. 25

Appendix 26

Select Balance Sheet and Other Data 3Q25 vs 2Q25 3Q25 vs 3Q24 $ in millions, except per share data 3Q25 2Q25 3Q24 $ Change % Change $ Change % Change Period End Balances Total loans $17,188.8 $17,111.1 $17,336.0 $77.7 - % $(147.2) (1) % Investment securities 3,319.3 5,996.9 6,349.8 (2,677.6) (45) (3,030.5) (48) Total assets 24,208.2 26,693.6 27,269.4 ( 2,485.5) (9) (3,061.2) (11) Total deposits 1 9,837.7 21,825.0 2 1,935.4 (1,987.3) (9) (2,097.7) (10) Borrowed funds 692.4 1,032.0 1,463.2 ( 339.6) (33) ( 770.8) (53) Total stockholders' equity 3,354.0 3,549.2 3,528.8 (195.2) (6) (174.9) (5) Average Balances Total loans $16,976.2 $17,046.8 $17,208.2 $(70.6) - % $(231.9) (1) % Investment securities 3,994.4 6,047.8 6,444.5 (2,053.4) (34) (2,450.0) (38) Total assets 24,914.9 26,645.1 27,216.4 (1,730.2) (6) (2,301.5) (8) Total deposits 20,529.1 21,431.0 2 1,717.4 ( 901.9) (4) (1,188.3) (5) Borrowed funds 699.5 1,359.7 1,670.5 ( 660.2) (49) ( 971.0) (58) Total stockholders' equity 3,368.3 3,546.2 3,505.1 ( 177.9) (5) ( 136.8) (4) Select Other Data Equity to assets 13.85 % 13.30 % 12.94 % 1 8.53 8.46 8.15 Tangible common equity to tangible assets Book value per share $23.18 $28.17 $28.11 1 13.45 16.97 16.78 Tangible book value per share Allowance for credit losses to total loans 1.50 % 1.48 % 1.35 % Nonperforming loan coverage ratio 168 161 229 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliations 27

Income Summary 3Q25 Adjusted 3Q25 vs Adjusted 1 $ in millions, except per share data 2Q25 3Q24 Reported Adjusted Net interest income $186.7 $186.7 $14.8 9 % $28.9 18 % Noninterest income (756.2) 45.9 3.5 8 0.4 1 Total revenue (569.5) 232.5 18.4 9 29.3 14 Noninterest expense 142.0 139.7 2.9 2 2.9 2 2 (711.6) 9 2.8 15.5 20 26.4 40 Pre-provision net revenue Provision for credit losses 1 2.0 12.0 - - ( 0.2) (1) Provision for income taxes (160.7) 1 5.9 6.6 71 7.6 92 Earnings ($562.8) $ 64.9 $8.9 16 % $18.9 41 % Diluted EPS $(4.00) $ 0.46 $0.02 5 % $0.09 24 % Totals may not foot due to rounding 1 Non-GAAP measures that management believes aid in the discussion of results. See appendix for Non-GAAP reconciliations 28 2 All pre-provision net revenue (PPNR) figures set forth in this row are Non-GAAP measures. See footnote 1 for more information

Non-GAAP Reconciliations 3Q 4Q 1Q 2Q 3Q $ in thousands, except per share data 2024 2024 2025 2025 2025 1 Calculation of Adjusted Earnings Net Income (Loss) $ 24,740 $ 48,319 $ 32,388 $ 54,773 $ (562,792) Certain items Branch right sizing, net 410 1,581 994 163 2,004 Loss (gain) on sale of securities 28,393 - - - 801,492 Early retirement program (1) 200 - 1,594 305 Loss on early extinguishment of debt - - - - 570 Termination of vendor and software services (13) - - - - Tax effect (7,524) (466) (260) (459) (176,649) Certain items, net of tax 21,265 1,315 734 1,298 627,722 Adjusted earnings (non-GAAP) $ 46,005 $ 49,634 $ 33,122 $ 56,071 $ 64,930 1 Calculation of Earnings and Adjusted Earnings per Diluted Share Earnings available to common shareholders $ 24,740 $ 48,319 $ 32,388 $ 54,773 $ (562,792) Diluted earnings per share $ 0.20 $ 0.38 $ 0.26 $ 0.43 $ (4.00) Adjusted earnings available to common shareholders (non-GAAP) $ 46,005 $ 49,634 $ 33,122 $ 56,071 $ 64,930 Adjusted diluted earnings per share (non-GAAP) $ 0.37 $ 0.39 $ 0.26 $ 0.44 $ 0.46 Average Diluted Shares Outstanding 125,999,269 126,232,084 126,336,557 126,406,453 140,648,704 1 In this presentation, “Adjusted Earnings” may also be referred to as “Adjusted Net Income” 29

Non-GAAP Reconciliations 3Q 4Q 1Q 2Q 3Q 2024 2024 2025 2025 2025 $ in thousands Calculation of Pre-Provision Net Revenue (PPNR) Net interest income $ 157,712 $ 164,942 $ 163,422 $ 171,824 $ 186,661 Noninterest income 17,130 43,558 46,155 42,354 (756,187) Less: Noninterest expense 137,193 141,117 144,580 138,589 142,032 Pre-Provision Net Revenue (PPNR) (non-GAAP) $ 37,649 $ 67,383 $ 64,997 $ 75,589 $ (711,558) Calculation of Adjusted Pre-Provision Net Revenue Pre-Provision Net Revenue (PPNR) (non-GAAP) $ 37,649 $ 67,383 $ 64,997 $ 75,589 $ (711,558) Plus: (Gain) loss on sale of securities 28,393 - - - 801,492 Plus: Branch right sizing costs, net 410 1,581 994 163 2,004 Plus: Early retirement program (1) 200 - 1,594 305 Plus: Loss on early extinguishment of debt - - - - 570 Plus: Termination of vendor and software services (13) - - - - Adjusted Pre-Provision Net Revenue (non-GAAP) $ 66,438 $ 69,164 $ 65,991 $ 77,346 $ 92,813 Calculation of PPNR and Adjusted PPNR Per Share Average Diluted Shares Outstanding 125,999,269 126,232,084 126,336,557 126,406,453 140,648,704 PPNR per Average Diluted Shares Outstanding $ 0.30 $ 0.53 $ 0.51 $ 0.60 $ (5.06) Adjusted PPNR per Average Diluted Shares Outstanding (non-GAAP) $ 0.53 $ 0.55 $ 0.52 $ 0.61 $ 0.66 Calculation of Book Value and Tangible Book Value per Share Total common stockholders' equity $ 3,528,833 $ 3,528,872 $ 3,531,485 $ 3,549,210 $ 3,353,963 Intangible assets: Goodwill (1,320,799) (1,320,799) (1,320,799) (1,320,799) (1,320,799) Other intangible assets (101,093) (97,242) (93,714) (90,617) (87,520) Total intangible assets (1,421,892) (1,418,041) (1,414,513) (1,411,416) (1,408,319) Tangible common stockholders' equity (non-GAAP) $ 2,106,941 $ 2,110,831 $ 2,116,972 $ 2,137,794 $ 1,945,644 Shares of common stock outstanding 125,554,598 125,651,540 125,926,822 125,996,248 144,703,075 Book value per common share $ 28.11 $ 28.08 $ 28.04 $ 28.17 $ 23.18 Tangible book value per common share (non-GAAP) $ 16.78 $ 16.80 $ 16.81 $ 16.97 $ 13.45 30

Non-GAAP Reconciliations 3Q 4Q 1Q 2Q 3Q 2024 2024 2025 2025 2025 $ in thousands, except number of employees (FTE) Calculation of Total Revenue and Adjusted Total Revenue Net Interest Income (GAAP) $ 157,712 $ 164,942 $ 163,422 $ 171,824 $ 186,661 Noninterest Income (GAAP) 17,130 43,558 46,155 42,354 (756,187) Total Revenue (non-GAAP) $ 174,842 $ 208,500 $ 209,577 $ 214,178 $ (569,526) Total Revenue (non-GAAP) $ 174,842 $ 208,500 $ 209,577 $ 214,178 $ (569,526) Less: Gain (loss) on sales of securities (28,393) - - - (801,492) Less: Loss on early extinguishment of debt - - - - (570) Adjusted Total Revenue (non-GAAP) $ 203,235 $ 208,500 $ 209,577 $ 214,178 $ 232,536 Employees (FTE) 2,972 2,946 2,949 2,947 2,883 Total Revenue per Employee (FTE) $ 58.83 $ 70.77 $ 71.07 $ 72.68 $ (197.55) Adjusted Total Revenue per Employee (FTE) $ 68.38 $ 70.77 $ 71.07 $ 72.68 $ 80.66 Calculation of Adjusted Noninterest Income Noninterest Income (GAAP) $ 17,130 $ 43,558 $ 46,155 $ 42,354 $ (756,187) Less: Gain (loss) on sale of securities (28,393) - - - (801,492) Less: Loss on early extinguishment of debt - - - - (570) Adjusted Noninterest Income (non-GAAP) $ 45,523 $ 43,558 $ 46,155 $ 42,354 $ 45,875 Calculation of Noninterest Income to Total Revenue Noninterest Income to Total Revenue 9.80% 20.89% 22.02% 19.78% NM Adjusted Noninterest Income to Adjusted Total Revenue (non-GAAP) 22.40% 20.89% 22.02% 19.78% 19.73% FTE – Full time equivalent NM – Not meaningful 31

Non-GAAP Reconciliations 3Q 4Q 1Q 2Q 3Q 2024 2024 2025 2025 2025 $ in thousands Calculation of Adjusted Noninterest Expense Noninterest Expense (GAAP) $ 137,193 $ 141,117 $ 144,580 $ 138,589 $ 142,032 Less: Branch right sizing expense 410 1,581 994 163 2,004 Less: Early retirement program (1) 200 - 1,594 305 Less: Termination of vendor and software services (13) - - - - Adjusted Noninterest Expense (non-GAAP) $ 136,797 $ 139,336 $ 143,586 $ 136,832 $ 139,723 Calculation of Efficiency Ratio and Adjusted Efficiency Ratio Noninterest Expense (efficiency ratio numerator) $ 137,193 $ 141,117 $ 144,580 $ 138,589 $ 142,032 Total Revenue $ 174,842 $ 208,500 $ 209,577 $ 214,178 $ (569,526) Fully taxable equivalent adjustment ___ _ _6,398 ___ _ _6,424 ___ _ _6,414 ___ _ _6,422 ___ _ _3,811 Efficiency ratio denominator $ 181,240 $ 214,924 $ 215,991 $ 220,600 $ (565,715) Efficiency ratio (based on GAAP figures) 75.70% 65.66% 66.94% 62.82% (25.11)% Adjusted Noninterest Expense (non-GAAP) $ 136,797 $ 139,336 $ 143,586 $ 136,832 $ 139,723 Less: Other real estate and foreclosure expense 87 317 198 216 200 Less: Amortization of intangible assets ___ __ 3,851 ___ __ 3,850 ___ __ 3,527 ___ __ 3,098 ___ __ 3,097 Adjusted efficiency ratio numerator (non-GAAP) $ 132,859 $ 135,169 $ 139,861 $ 133,518 $ 136,426 Adjusted Total Revenue (non-GAAP) (reconciliation shown on page 31) $ 203,235 $ 208,500 $ 209,577 $ 214,178 $ 232,536 Fully taxable equivalent adjustment ___ _ _6,398 ___ _ _6,424 ___ _ _6,414 ___ _ _6,422 ___ _ _3,811 Adjusted efficiency ratio denominator (non-GAAP) $ 209,633 $ 214,924 $ 215,991 $ 220,600 $ 236,347 Adjusted Efficiency Ratio (non-GAAP) 63.38% 62.89% 64.75% 60.52% 57.72% Fully taxable equivalent adjustment using an effective tax rate of 26.135% 32

Non-GAAP Reconciliations 3Q 2Q 3Q 2024 2025 2025 $ in thousands Calculation of Adjusted Salaries and Employee Benefits Salaries and employee benefits (GAAP) $ 69,167 $ 73,862 $ 76,249 Less: Early retirement program (1) 1,594 305 Less: Other 1 (1) 1 Total Adjusted Salaries and Employee Benefits (non-GAAP) $ 69,167 $ 72,269 $ 75,943 Calculation of Adjusted Occupancy Expense, Net Occupancy expense, net (GAAP) $ 12,216 $ 11,844 $ 12,106 Less: Branch right sizing expense 224 396 432 Total Adjusted Occupancy Expense (non-GAAP) $ 11,992 $ 11,448 $ 11,674 Calculation of Adjusted Furniture and Equipment Expense Furniture and Equipment Expense (GAAP) $ 5,612 $ 5,474 $ 5,275 Less: Branch right sizing expense 1 23 15 Total Adjusted Furniture and Equipment Expense (non-GAAP) $ 5,611 $ 5,451 $ 5,260 Calculation of Adjusted Other Noninterest Expense Other noninterest expense (GAAP) $ 44,540 $ 42,276 $ 43,027 Less: Branch right sizing expense (13) (255) 1,556 Less: Termination of vendor and software services 184 - - Total Adjusted Other Noninterest Expense (non-GAAP) $ 44,369 $ 42,531 $ 41,471 Calculation of Adjusted Provision for Income Taxes Provision for income taxes (GAAP) $ 761 $ 8,871 $ (160,732) Less: Tax effect of certain items (non-GAAP) (reconciliation shown on page 29) (7,524) (459) (176,649) Adjusted provision for income taxes (non-GAAP) $ 8,285 $ 9,330 $ 15,917 33

Non-GAAP Reconciliations 3Q 2Q 3Q 2024 2025 2025 $ in thousands Calculation of Uninsured, Non-Collateralized Deposit Coverage Ratio Uninsured deposits at Simmons Bank $ 8,355,496 $ 8,407,847 $ 9,565,766 Less: Collateralized deposits (excluding portion that is FDIC insured) 2,710,167 2,691,215 2,169,362 Less: Intercompany eliminations ______ 986,626 _____1,121,932 _____2,937,147 Total uninsured, non-collateralized deposits (non-GAAP) $ 4,658,703 $ 4,594,700 $ 4,459,257 FHLB borrowing availability $ 4,955,000 $ 5,133,000 $ 6,134,000 Unpledged securities 4,110,000 3,697,000 1,575,000 Fed funds lines and Fed discount window 2,109,000 1,894,000 1,824,000 Additional liquidity sources $ 11,174,000 $ 10,724,000 $ 9,533,000 Uninsured, non-collateralized deposit coverage ratio (non-GAAP) 2.4x 2.3x 2.1x Calculation of Net Charge-Off Ratio, Excluding Run-Off Portfolio Net charge-offs $ 9,314 $ 10,576 $ 10,711 Less: Net charge-offs from run-off portfolio ______ 3,500 ______ 1,100 ______ 500 Net charge-offs excluding run-off portfolio (non-GAAP) $ 5,814 $ 9,476 $ 10,211 Average total loans $ 17,208,162 $ 17,046,802 $ 16,976,231 Net charge-offs as a percentage of average total loans (annualized) (NCO ratio) 0.22% 0.25% 0.25% NCO ratio excluding NCOs associated with run-off portfolios (annualized) (non- GAAP) 0.13% 0.22% 0.24% 34

Non-GAAP Reconciliations 1Q 2Q 3Q 2025 2025 2025 $ in thousands Calculation of NPL ratio, excluding Two Specific Credit Relationships Nonperforming loans $ 152,391 $ 157,162 $ 153,939 Less: Two Specific Credit Relationships 49,761 49,572 49,267 Nonperforming Loans, excluding Two Specific Credit Relationships (non-GAAP) $ 102,630 $ 107,590 $ 104,672 Total loans $ 17,094,078 $ 17,111,096 $ 17,188,817 Less: Two Specific Credit Relationships 49,761 49,572 49,267 Total Loans, excluding Two Specific Credit Relationships (non-GAAP) $ 17,044,317 $ 17,061,524 $ 17,139,550 Nonperforming loans ratio (NPL Ratio) 0.89% 0.92% 0.90% NPL ratio, excluding Two Specific Credit Relationships (non-GAAP) 0.60% 0.63% 0.61% Calculation of NPA to Total Assets, excluding Two Specific Credit Relationships Nonperforming assets $ 162,345 $ 166,715 $ 160,717 Less: Two Specific Credit Relationships 49,761 49,572 49,267 Nonperforming Assets, excluding Two Specific Credit Relationships (non-GAAP) $ 112,584 $ 117,143 $ 111,450 Total assets $ 26,792,991 $ 26,693,620 $ 24,208,162 Less: Two Specific Credit Relationships 49,761 49,572 49,267 Total Assets, excluding Two Specific Credit Relationships (non-GAAP) $ 26,743,230 $ 26,644,048 $ 24,158,895 Nonperforming assets to total assets 0.61% 0.62% 0.66% Nonperforming assets to total assets, excluding Two Specific Credit Relationships (non-GAAP) 0.42% 0.44% 0.46% 35

Non-GAAP Reconciliations 2Q 3Q 2Q 3Q 2025 2025 2025 2025 $ in thousands $ in thousands Calculation of Tangible Common Equity (TCE) Calculation of Adjusted ROAA Total common stockholders’ equity $ 3,549,210 $ 3,353,963 Net income $ 54,773 $ (562,792) Less: Intangible assets 1,411,416 1,408,319 Adjusted earnings (non-GAAP) (reconciliation shown on page 29) $ 56,071 $ 64,930 Total tangible common stockholders’ equity (non-GAAP) $ 2,137,794 $ 1,945,644 Average assets $ 26,645,131 $ 24,914,922 Total assets $ 26,693,620 $ 24,208,162 Return on average assets (ROAA) 0.82% (8.96)% Less: Intangible assets 1,411,416 1,408,319 Adjusted ROAA (non-GAAP) 0.84% 1.03% Total tangible assets $ 25,282,204 $ 22,799,843 Calculation of Adjusted ROTCE Common equity to total assets 13.30% 13.85% Net income $ 54,773 $ (562,792) Tangible common equity to tangible common assets (non-GAAP) 8.46% 8.53% Plus: Amortization of intangible assets, net of taxes 2,289 2,287 Total tangible net income (non-GAAP) $ 57,062 $ (560,505) Adjusted earnings (non-GAAP) (reconciliation shown on page 29) $ 56,071 $ 64,930 Plus: Amortization of intangible assets, net of taxes 2,289 2,287 Total adjusted tangible net income (non-GAAP) $ 58,360 $ 67,217 Average common stockholders’ equity $ 3,546,163 $ 3,368,308 Less: Average intangible assets 1,413,231 1,410,148 Average tangible common stockholders’ equity (non-GAAP) $ 2,132,932 $ 1,958,160 Return on average common equity (ROCE) 6.20% (66.29)% Return on average tangible common equity (ROTCE) (non-GAAP) 10.73% (113.56)% Adjusted return on average common equity (non-GAAP) 6.34% 7.65% Adjusted return on tangible common equity (non-GAAP) 10.97% 13.62% 36

Non-GAAP Reconciliations 2Q 2Q 2025 2025 $ in thousands $ in thousands Calculation of Tier 1 Leverage Ratio Calculation of Total Risk-Based Capital Ratio Stockholders’ equity $ 3,549,210 Tier 1 capital $ 2,551,006 Less: Disallowed intangible assets, net of deferred tax 1,379,104 Plus: Subordinated notes and debentures 366,369 Less: Unrealized loss (gain) on AFS securities 380,900 Less: Subordinated debt phase out (198,000) Tier 1 capital $ 2,551,006 Plus: Qualifying allowance for credit losses and reserve for unfunded commitments 258,079 Total risk-based capital $ 2,977,454 Tier 1 capital $ 2,551,006 Less: Market value adjustment on HTM securities transferred to AFS, net of tax 501,063 Total risk-based capital $ 2,977,454 Adjusted Tier 1 capital $ 2,049,943 Less: Loss on securities sale and repositioning 606,729 Adjusted total risk-based capital $ 2,370,725 Average assets for leverage ratio $ 25,606,135 Less: Market value adjustment on HTM securities transferred to AFS, net of tax 501,063 Risk weighted assets $ 20,646,324 Adjusted average assets for leverage ratio $ 25,105,072 Less: Securities sale and repositioning (assuming 32.9% risk weighting) 943,205 Adjusted risk weighted assets $ 19,703,119 Tier 1 Leverage Ratio 9.96% Adjusted Tier 1 Leverage Ratio (Economic Capital) (non-GAAP) 8.17% Total Risk-Based Capital Ratio 14.42% Adjusted Total Risk-Based Capital Ratio (Economic Capital) (non-GAAP) 12.03% 1 Calculation of CET 1 Capital Ratio Tier 1 capital $ 2,551,006 Less: Loss on securities sale and repositioning 606,729 Adjusted Tier 1 capital $ 1,944,277 Risk weighted assets $ 20,646,324 Less: Securities sale and repositioning (assuming 32.9% risk weighting) 943,205 Adjusted risk weighted assets $ 19,703,119 CET 1 Capital Ratio 12.36% Adjusted CET 1 Capital Ratio Ratio (Economic Capital) (non-GAAP) 9.87% 1 At June 30, 2025, the CET 1 Capital Ratio and the Tier 1 Risk-Based Capital Ratio were the same for the Company 37

Non-GAAP Reconciliations September September 2025 2025 $ in thousands $ in thousands Calculation of Adjusted ROAA Calculation of Pre-Provision Net Revenue (PPNR) Net income $ 21,147 Net interest income $ 63,171 Plus: Branch right sizing costs 1,788 Plus: Noninterest income 15,734 Plus : Loss on early extinguishment of debt 570 Less: Noninterest expense 49,802 Less: Tax effect (616) Pre-Provision Net Revenue (PPNR) (non-GAAP) $ 29,103 Adjusted earnings (non-GAAP) $ 22,889 Calculation of Adjusted Pre-Provision Net Revenue Pre-Provision Net Revenue (PPNR) (non-GAAP) $ 29,103 Average assets $ 24,162,450 Plus: Branch right sizing costs, net 1,788 Return on average assets (ROAA) 1.06% Plus: Loss on early extinguishment of debt 570 Adjusted ROAA (non-GAAP) 1.15% Adjusted Pre-Provision Net Revenue (non-GAAP) $ 31,461 Calculation of Adjusted ROTCE Adjusted Pre-Provision Net Revenue (Non-GAAP) quarterized $ 96,480 Net income $ 21,147 Plus: Amortization of intangible assets, net of taxes 762 Total tangible net income (non-GAAP) $ 21,909 Adjusted earnings (non-GAAP) (reconciliation shown above) $ 22,889 Plus: Amortization of intangible assets, net of taxes 762 Total adjusted tangible net income (non-GAAP) $ 23,651 Average common stockholders’ equity $ 3,343,526 Less: Average intangible assets 1,409,145 Average tangible common stockholders’ equity (non-GAAP) $ 1,934,381 Return on average common equity (ROCE) 7.70% Return on average tangible common equity (ROTCE) (non-GAAP) 13.78% Adjusted return on average common equity (non-GAAP) 8.33% Adjusted return on tangible common equity (non-GAAP) 14.88% 38

Nasdaq SFNC rd 3 Quarter 2025 Earnings Presentation October 16, 2025


501 Main Street, Pine Bluff, Arkansas				71601
(Address of principal executive offices)				(Zip Code)


Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common stock, par value $0.01 per share	SFNC	The Nasdaq Global Select Market


Exhibit 99.1		Press Release dated October 16, 2025

Exhibit 99.2		Investor Presentation issued on October 16, 2025

Exhibit 104		Cover Page Interactive Data File (embedded within the Inline XBRL Document)