Exhibit 99.1

July 21, 2022

Simmons First National Corporation Reports Second Quarter 2022 Earnings

George A. Makris, Jr., Simmons’ Chairman and CEO, commented on the quarter

Although second quarter results were significantly impacted by accounting adjustments and one-time merger expenses related to our acquisition of Spirit of Texas Bancshares during the quarter, Simmons’ operating results excluding these items were extremely strong. Highlights for the quarter include a significant increase in revenue, well contained operating expense growth, improved asset quality, annualized organic loan growth in excess of 25 percent, marked improvement in the efficiency ratio, substantial expansion of the net interest margin, and excellent capital ratios.

Our strategy of restructuring our loan portfolio over the past two years not only diversified the risk profile but also established capacity which should provide the foundation for additional loan and revenue growth, which is evident in our loan pipeline and unfunded commitments. Our liquidity is solid, and our capital is strong. We are growing in all markets as demonstrated by the addition of nearly 2,000 new business deposit accounts in the quarter.

Thanks to our continuing investment in technology associated with our NGB project, our digital products continue to be expanded and our Chief Digital Officer, Alex Carriles, was recently recognized as a “Digital Banker of the Year” by American Banker. Other initiatives, such as the engagement of Disney Institute to help us focus on our customer service standards, will continue to headline our “Better Bank” objective.

I am very proud of the members of our Simmons team who truly exemplify our Better Together cultural cornerstone.

Financial Highlights	2Q22	1Q22	2Q21	Second Quarter Highlights
Financial Results (in millions)				· Diluted EPS was $0.21 and adjusted diluted EPS was $0.52 · Revenue increased 20% on a linked quarter basis driven by the acquisition of Spirit, solid legacy SFNC net interest income growth and net interest margin expansion · Noninterest expenses increased 22% on a linked quarter basis. Excluding merger related costs and certain other items, adjusted noninterest expense increased 9% · Provision for credit losses totaled $33.9 million, reflecting Day 2 accounting provision for acquired loans and unfunded commitments · Total loans up 26% and total deposits up 14% on a linked quarter basis. Legacy SFNC loans up 7% and deposits relatively unchanged · Credit quality metrics reflect conservative risk profile and strategic decision in 2019 to de-risk acquired loan portfolios · Common equity to assets ratio at 11.98%; TCE ratio at 7.03%
Revenue	$ 225.4	$ 187.9	$ 188.5
Noninterest expense	156.8	128.4	114.7
Pre-provision net revenue⁽¹⁾	68.6	59.5	73.9
Merger related costs	19.1	1.9	0.7
Adjusted pre-provision net revenue⁽¹⁾	88.1	62.3	74.6
Provision for credit losses	33.9	(19.9)	(13.0)
Net income	27.5	65.1	74.9
Per Share Data
Diluted earnings	$ 0.21	$ 0.58	$ 0.69
Adjusted diluted earnings⁽¹⁾	0.52	0.59	0.69
Book value	25.31	26.32	28.03
Tangible book value⁽¹⁾	14.07	15.22	17.16
Avg diluted shares outstanding (000s)	128,720	113,027	108,822
Balance Sheet (in millions)
Total loans	$ 15,110	$ 12,029	$ 11,386
Total deposits	22,036	19,392	18,305
Total shareholders’ equity	3,260	2,962	3,039
Asset Quality
Net charge-off ratio	0.02%	0.22%	(0.07)%
Nonperforming loan ratio	0.42	0.53	0.71
Nonperforming assets to total assets	0.26	0.29	0.42
Allowance for credit losses to total loans	1.41	1.49	2.00
Nonperforming loan coverage ratio	334	278	281
Select Ratios
Net interest margin (FTE)	3.24	2.76	2.89
Efficiency ratio⁽¹⁾	57.49	62.95	56.75
Loan to deposit ratio	68.57	62.03	62.20
Common equity tier 1 (CET1) ratio	12.10	13.52	14.20
Total risk-based capital ratio	14.83	16.42	17.49

Revenue is defined as net interest income plus noninterest income excluding gain (loss) on sale of securities

(1) Non-GAAP measurement. See “Reconciliation of Non-GAAP Financial Measures” below

FTE – fully taxable equivalent using a tax rate of 26.135%

Simmons First National Corporation (NASDAQ: SFNC) (Simmons or Company) today reported net income of $27.5 million for the second quarter of 2022, compared to $65.1 million in the first quarter of 2022 and $74.9 million in the second quarter of 2021. Diluted earnings per share were $0.21 for the second quarter of 2022, compared to $0.58 for the first quarter of 2022 and $0.69 for the second quarter of 2021. Included in second quarter 2022 results were $14.4 million (after-tax) of certain items, primarily merger-related expenses associated with our acquisition of Spirit of Texas Bancshares, Inc. (Spirit) that was completed on April 8, 2022. Certain items, consisting primarily of merger-related expenses and branch right-sizing costs, totaled $2.1 million (after-tax) in the first quarter of 2022 and $0.5 million (after-tax) in the second quarter of 2021.

Additionally, second quarter 2022 results included a $33.8 million Day 2 accounting provision required for loans and unfunded commitments acquired in connection with our second quarter acquisition. Excluding these items, adjusted diluted earnings per share were $0.52 for the second quarter of 2022, $0.59 for the first quarter of 2022 and $0.69 for the second quarter of 2021.

Impact of Certain Items on Earnings and Diluted EPS

$ in millions, except per share data		Q2 22			Q1 22			Q2 21
Net income	$	27.5		$	65.1		$	74.9

Day 2 accounting provision		33.8			-			-
Merger related expenses		19.1			1.9			0.7
Branch right sizing costs, net		0.4			0.9			-
Total pre-tax impact		53.3			2.8			0.7
Tax effect⁽¹⁾		(14.0	)		(0.7	)		(0.2	)
Total impact on earnings		39.3			2.1			0.5
Adjusted earnings⁽²⁾	$	66.8		$	67.2		$	75.4

Diluted EPS	$	0.21		$	0.58		$	0.69

Day 2 accounting provision		0.26			-			-
Merger related expenses		0.15			0.01			0.01
Branch right sizing costs		-			0.01			-
Total pre-tax impact		0.41			0.02			0.01
Tax effect⁽¹⁾		(0.10	)		(0.01	)		(0.01	)
Total impact on earnings		0.31			0.01			-
Adjusted Diluted EPS⁽²⁾	$	0.52		$	0.59		$	0.69

Average diluted shares outstanding		128,720,078			113,026,911			108,822,175

(1) Effective tax rate of 26.135%

(2) Non-GAAP measurement. See “Reconciliation of Non-GAAP Financial Measures” below

Net Interest Income

Net interest income for the second quarter of 2022 totaled $185.1 million, compared to $145.6 million in the first quarter of 2022 and $146.5 million for the second quarter of 2021. Included in net interest income is accretion recognized on loans acquired, which totaled $9.9 million in the second quarter of 2022, $3.7 million in the first quarter of 2022 and $5.6 million in the second quarter of 2021. Also included in net interest income is interest income from Paycheck Protection Program (PPP) loans totaling $1.6 million in the second quarter of 2022, $2.1 million in the first quarter of 2022 and $9.0 million in the second quarter of 2021. The increase in net interest income on a linked quarter basis was driven by a $43.1 million increase in interest income, that was fueled by SFNC legacy net loan growth, the added contribution from loans acquired in the Spirit acquisition and higher yields on loans and investment securities. The increase in net interest income was also positively impacted by a significant decrease in the level of variable rate loans at or below their interest rate floors during the quarter. These items more than offset the $3.6 million increase in interest expense on a linked quarter basis, which was partially attributable to the addition of deposits acquired in the Spirit acquisition.

The yield on loans for the second quarter of 2022 was 4.54 percent, compared to 4.34 percent in the first quarter of 2022 and 4.73 percent in the second quarter of 2021. The yield on investments securities for the second quarter of 2022 was 2.08 percent, compared to 1.86 percent in the first quarter of 2022 and 1.97 percent in the second quarter of 2021. Cost of deposits for the second quarter of 2022 were relatively stable at 18 basis points, compared to 14 basis points in the first quarter of 2022 and below the 24 basis points incurred during the second quarter of 2021. Net interest margin on a fully taxable equivalent basis for the second quarter of 2022 was 3.24 percent, compared to 2.76 percent for the first quarter of 2022 and 2.89 percent for the second quarter of 2021. Excluding the impact of PPP loan interest income, the net interest margin was 3.22 percent for the second quarter of 2022, 2.74 percent for the first quarter of 2022 and 2.81 percent for the second quarter of 2021.

	Q2 22		Q1 22		Q4 21		Q3 21		Q2 21
Loan yield (FTE) ⁽¹⁾	4.54	%	4.34	%	4.58	%	4.76	%	4.73	%
Security yield (FTE) ⁽¹⁾	2.08		1.86		1.74		1.77		1.97
Cost of interest bearing deposits	0.25		0.19		0.23		0.27		0.32
Cost of deposits	0.18		0.14		0.17		0.20		0.24
Cost of borrowed funds	2.13		1.94		1.95		1.96		1.97
Net interest spread (FTE) ⁽¹⁾	3.11		2.66		2.74		2.72		2.74
Net interest margin (FTE) ⁽¹⁾	3.24		2.76		2.86		2.85		2.89

(1) Fully tax equivalent using an effective tax rate of 26.135%.

Noninterest Income

Noninterest income for the second quarter of 2022 was $40.2 million, compared to $42.2 million in the first quarter of 2022 and $47.1 million in the second quarter of 2021. Included in noninterest income in the first quarter of 2022 was a settlement award totaling $1.4 million. Gains (losses) on sales of investment securities totaled $(150) thousand in the second quarter of 2022, $(54) thousand in the first quarter of 2022 and $5.1 million in the second quarter of 2021. The decrease in noninterest income on a linked quarter basis was primarily attributable to an expected decline in mortgage lending income given the higher interest rate environment and softening market conditions, and the previously mentioned settlement award. These declines were offset, in part, by an increase in debit and credit card fees, and an increase in service charges on deposit accounts that was aided by the addition of Spirit.

Select Noninterest Income Items $ in millions		Q2 22			Q1 22			Q4 21			Q3 21		Q2 21
Service charges on deposit accounts	$	11.4		$	10.7		$	11.9		$	11.6	$	10.1
Wealth management fees		7.2			8.0			8.0			7.9		7.9
Debit and credit card fees ⁽¹⁾		8.2			7.4			7.5			7.1		7.1
Mortgage lending income		2.2			4.6			5.0			5.8		4.5
Bank owned life insurance		2.6			2.7			2.8			2.6		2.0
Gain (loss) on sale of securities		(0.2	)		(0.1	)		(0.3	)		5.2		5.1
Other income		6.8			7.3			10.0			6.4		8.4

Adjusted other income ⁽²⁾		6.9			7.3			10.0			6.7		8.0

(1) During the second quarter of 2021, certain debit and credit card transaction fees were reclassified from noninterest expense to noninterest income. Prior periods have been adjusted to reflect this reclassification.

(2) Adjusted figures exclude certain items and are non-GAAP measurements. Please see “Non-GAAP Financial Measures” and “Reconciliation of Non-GAAP Financial Measures” below.

Noninterest Expense

Noninterest expense for the second quarter of 2022 was $156.8 million, compared to $128.4 million in the first quarter of 2022 and $114.7 in the second quarter of 2021. Included in noninterest expense in the second quarter of 2022 is a $1.6 million contribution to the Simmons First Foundation Conservation Fund, reflecting a portion of paper statement fees collected as part of a promotion to encourage customers to enroll in eStatements. Also included in noninterest expense are certain non-core items, primarily associated with merger related and branch right-sizing costs, totaling $19.4 million in the second quarter of 2022, $2.8 million in the first quarter of 2022 and $1.2 million in the second quarter of 2021. Excluding these items, adjusted noninterest expense for the second quarter of 2022 was $137.4 million, compared to $125.6 million in the first quarter of 2022 and $113.5 million in the second quarter of 2021. The increase in adjusted noninterest expense on a linked quarter basis was primarily attributable to operating expenses associated with Spirit. The increase in adjusted noninterest expense on a year-over-year basis primarily reflects increased operating expenses associated with the acquisition of Spirit, and the acquisitions of Landmark Community Bank and Triumph Bancshares, Inc. in the fourth quarter of 2021.

Select Noninterest Expense Items $ in millions		Q2 22		Q1 22		Q4 21		Q3 21		Q2 21
Salaries and employee benefits	$	74.1	$	67.9	$	63.9	$	61.9	$	60.3
Occupancy expense, net		11.0		10.0		11.0		9.4		9.1
Furniture and equipment		5.1		4.8		4.7		4.9		4.9
Merger related costs		19.1		1.9		13.6		1.4		0.7
Other operating expenses ⁽¹⁾		44.5		41.6		45.7		34.6		37.2

Adjusted salaries and employee benefits ⁽²⁾		74.1		67.9		63.8		61.8		60.3
Adjusted other operating expenses ⁽²⁾		44.5		40.9		45.8		38.3		37.1

(2) Adjusted figures exclude certain items and are non-GAAP measurements. Please see “Non-GAAP Financial Measures” and “Reconciliation of Non-GAAP Financial Measures” below.

Loans and Unfunded Loan Commitments

Total loans at the end of the second quarter of 2022 were $15.1 billion, compared to $12.0 billion at the end of the first quarter of 2022 and $11.4 billion at the end of the second quarter of 2021. The increase in total loans on a linked quarter basis reflected the addition of $2.3 billion of loans (net of fair value adjustments) associated with the acquisition of Spirit. Excluding Spirit loans acquired at closing, net loan growth on a linked quarter basis was $822 million, or 7 percent. Net loan growth in the quarter was also driven by increased activity throughout our geographic footprint, which more than offset an anticipated decline in mortgage warehouse lending given current market conditions, as well as the continued forgiveness of PPP loans. Additionally, loan growth was weighted toward the latter half of the quarter as average total loans for the second quarter of 2022 were $14.5 billion. The higher level of period end loan balances compared to average balances should provide a platform for interest income growth going forward.

Unfunded commitments increased for the fifth consecutive quarter to $4.5 billion, up 30 percent on a linked quarter basis. Continued growth in this measure was aided by the addition of Spirit, and we believe reflects the Company’s ability to organically attract new customers throughout its franchise while also deepening relationships with existing customers. At the same time, momentum in our commercial loan pipeline continued to strengthen with all loan opportunities, including the addition of Spirit, totaling $3.0 billion at the end of the second quarter of 2022, up 28 percent on a linked quarter basis. This marked the seventh consecutive quarter of increased activity in our commercial loan pipeline. Commercial loans approved and ready to close at the end of the second quarter totaled $1.1 billion and the rate on ready to close commercial loans was 4.45 percent, up 102 basis points from the rate on ready to close commercial loans at the end of the first quarter of 2022.

$ in millions		Q2 22			Q1 22		Q4 21		Q3 21		Q2 21
Total loans	$	15,110		$	12,029	$	12,013	$	10,825	$	11,386
Spirit loans, net of fair value adjustments		2,259
Total loans (excluding Spirit)(1) (2)	$	12,851

Linked quarter change in loans		26	%
Linked quarter change in loans (excluding Spirit)^{(1) (2)}		7

PPP loans	$	19		$	62	$	117	$	212	$	441
Mortgage warehouse loans		168			166		230		275		307
Energy loans		55			48		105		128		174

Unfunded loan commitments	$	4,473		$	3,428	$	2,943	$	2,254	$	2,130

(1) Adjusted figures exclude certain items and are non-GAAP measurements. Please see “Non-GAAP Financial Measures” below

(2) Loans excluding Spirit loans are also referred to as “Legacy SFNC loans” in this earnings release.

Deposits

Total deposits at the end of the second quarter of 2022 were $22.0 billion, compared to $19.4 billion at the end of the first quarter of 2022 and $18.3 billion at the end of the second quarter of 2021. The increase in total deposits on a linked quarter basis reflected the addition of $2.7 billion of deposits (net of fair value adjustments) associated with the acquisition of Spirit. Excluding Spirit deposits acquired at closing, total deposits were relatively unchanged on a linked quarter basis, decreasing less than 1 percent. Noninterest bearing deposits totaled $6.1 billion at the end of the second quarter of 2022 and represented 27 percent of total deposits, unchanged from first quarter of 2022 levels. Interest bearing deposits (checking, savings and money market accounts) totaled $12.8 billion at the end of the second quarter of 2022 and represented 58 percent of total deposits, compared to 62 percent of total deposits at the end of the first quarter of 2022. Conversely, time deposits totaled $3.2 billion at the end of the second quarter of 2022 and represented 14 percent of total deposits, up from 11 percent at the end of the first quarter of 2022. The change in mix of deposits on a linked quarter basis is partially attributable to the attractiveness of higher rate deposits given the rapid increase in interest rates that has occurred during 2022, coupled with the mix of deposits acquired from Spirit. The loan to deposit ratio ended the second quarter of 2022 at 69 percent, up from 62 percent at the end of both the first quarter of 2022 and the second quarter of 2021.

$ in millions		Q2 22			Q1 22		Q4 21		Q3 21		Q2 21
Noninterest bearing deposits	$	6,057		$	5,224	$	5,325	$	4,919	$	4,894
Interest bearing deposits		12,816			12,106		11,589		10,697		10,570
Time deposits		3,163			2,062		2,453		2,456		2,841
Total deposits	$	22,036		$	19,392	$	19,367	$	18,072	$	18,305
Spirit deposits, net of fair value adjustments		2,719
Total deposits (excluding Spirit)(1) (2)	$	19,317

Linked quarter change in deposits		14	%
Linked quarter change in deposits (excluding Spirit) ^{(1) (2)}		—

(1) Adjusted figures exclude certain items and are non-GAAP measurements. Please see “Non-GAAP Financial Measures” below.

(2) Deposits excluding Spirit deposits are also referred to as “Legacy SFNC deposits” in this earnings release.

Asset Quality

Total nonperforming loans at the end of the second quarter of 2022 were $63.6 million, down $0.7 million compared to $64.3 million at the end of the first quarter of 2022 and down $17.3 million compared to $80.9 million at the end of the second quarter of 2021. Total nonperforming assets as a percentage of total assets were 0.26 at the end of the second quarter of 2022, compared to 0.29 percent at the end of the first quarter of 2022 and 0.42 percent at the end of the second quarter of 2021. Net charge-offs as a percentage of average loans were 2 basis points in the second quarter of 2022, compared to 22 basis points in the first quarter of 2022 and net recoveries of 7 basis points in the second quarter of 2021.

Improving asset quality metrics reflect both economic conditions in the markets we serve, as well as the impact of the Company’s strategic decision in 2019 designed to de-risk loan portfolios that were acquired in connection with its geographic diversification and expansion. As a result of this strategic decision, over the past two years the Company has prudently and systematically exited certain non-relationship credits and non-core industries while also significantly reducing its exposure to commercial real estate to more acceptable levels.

During the second quarter of 2022, the Company recorded a provision for credit losses totaling $33.9 million, compared to provision recaptures of $19.9 million in the first quarter of 2022 and $13.0 million in the second quarter of 2021. The provision for credit losses in the second quarter of 2022 includes $33.8 million associated with Day 2 accounting provision required for loans and unfunded commitments acquired during the quarter in connection with the acquisition of Spirit.

The allowance for credit losses on loans at the end of the second quarter of 2022 was $212.6 million, compared to $178.9 million at the end of the first quarter of 2022 and $227.2 million at the end of the second quarter of 2021. Included in the allowance for credit losses in the second quarter of 2022 is the impact of the Day 2 accounting provision related to Spirit, as well as fair value purchase accounting credit marks of $4.1 million. The allowance for credit losses on loans to total loans ratio ended the quarter at 1.41 percent, compared to 1.49 percent at the end of the first quarter of 2022 and 2.00 percent at the end of the second quarter of 2021. The nonperforming loan coverage ratio ended the quarter at 334 percent, compared to 278 percent at the end of the first quarter of 2022 and 281 percent at the end of the second quarter of 2021.

$ in millions		Q2 22			Q1 22			Q4 21			Q3 21			Q2 21
Allowance for credit losses on loans to total loans		1.41	%		1.49	%		1.71	%		1.87	%		2.00	%
Allowance for credit losses on loans to nonperforming loans		334			278			300			341			281
Nonperforming loans to total loans		0.42			0.53			0.57			0.55			0.71
Net charge-off ratio (annualized)		0.02			0.22			0.31			0.17			(0.07	)
Net charge-off ratio YTD (annualized)		0.11			0.22			0.13			0.06			0.01

Total nonperforming loans	$	63.6		$	64.3		$	68.6		$	59.4		$	80.9
Total other nonperforming assets		6.4			6.6			7.7			13.5			16.3
Total nonperforming assets	$	70.0		$	70.9		$	76.3		$	72.9		$	97.2

Capital

Total common stockholders’ equity at the end of the second quarter of 2022 was $3.3 billion, compared to $3.0 billion at the end of both the first quarter of 2022 and second quarter of 2021. The increase in common stockholders’ equity on a linked quarter basis reflects the issuance of shares in connection with the acquisition of Spirit and earnings for the quarter, partially offset by the return of capital to shareholders through share repurchases and the payment of a cash dividend, and an increase in unrealized losses associated with investment securities classified as available-for-sale. Book value per share at the end of the second quarter of 2022 was $25.31, compared to $26.32 at the end of the first quarter of 2022 and $28.03 and the end of the second quarter of 2021. Tangible book value per share was $14.07 at the end of the second quarter of 2022, compared to $15.22 at the end of the first quarter of 2022 and $17.16 at the end of the second quarter of 2021. The ratio of stockholders’ equity to total assets at June 30, 2022, was 12.0 percent and the ratio of tangible common equity to tangible assets was 7.0 percent. All of Simmons’ regulatory capital ratios continue to significantly exceed “well-capitalized” guidelines.

	Q2 22		Q1 22		Q4 21		Q3 21		Q2 21
Stockholders’ equity to total assets	12.0	%	12.1	%	13.1	%	13.1	%	13.0	%
Tangible common equity to tangible assets ⁽¹⁾	7.0		7.4		8.5		8.4		8.4
Regulatory common equity tier 1 ratio	12.1		13.5		13.8		14.3		14.2
Regulatory tier 1 leverage ratio	9.2		9.0		9.1		9.1		9.0
Regulatory tier 1 risk-based capital ratio	12.1		13.5		13.8		14.3		14.2
Regulatory total risk-based capital ratio	14.8		16.4		16.8		17.4		17.5

(1) Tangible common equity to tangible assets is a non-GAAP measurement. Please see “Non-GAAP Financial Measures” and “Reconciliation of Non-GAAP Financial Measures” below.

Share Repurchase Program and Cash Dividend

As previously announced, as a result of the Simmons’ strong capital position and ability to organically generate capital, the board of directors declared a quarterly cash dividend on Simmons’ Class A common stock of $0.19 per share, which is payable on October 3, 2022, to shareholders of record as of September 15, 2022. The cash dividend rate represents an increase of $0.01 per share, or 6 percent, from the dividend paid for the same time period last year. The current quarterly cash dividend rate further represents an annualized cash dividend rate of $0.76 per share and a ten-year compound annual growth rate of 7 percent. With the payment of dividends in 2022, Simmons has paid cash dividends for 113 consecutive years. According to research performed by Dividend Power, Simmons is one of only 23 U.S. publicly traded companies that have paid dividends for 100+ uninterrupted years. Simmons was one of only two banks to be named to the list and tied for second among Nasdaq listed companies for the longest active streak.

During the second quarter of 2022, Simmons repurchased approximately 2.0 million shares of its Class A common stock at an average price of $24.57 under its 2022 stock repurchase program that was announced in January 2022 (2022 Program). Under the 2022 Program, Simmons is authorized to repurchase up to $175,000,000 of its issued and outstanding Class A common stock. Market conditions and our capital needs will drive the decisions regarding future stock repurchases, the timing, pricing and amount of any repurchases under the 2022 Program will be determined by Simmons’ management at its discretion, and the 2022 Program does not obligate Simmons to repurchase any common stock and may be modified, discontinued or suspended at any time without prior notice.

Simmons First National Corporation

Simmons First National Corporation (NASDAQ: SFNC) is a Mid-South based financial holding company that has paid cash dividends to its shareholders for 113 consecutive years. Its principal subsidiary, Simmons Bank, operates more than 230 branches in Arkansas, Kansas, Missouri, Oklahoma, Tennessee and Texas. Founded in 1903, Simmons Bank offers comprehensive financial solutions delivered with a client-centric approach. Simmons Bank was named to Forbes list of “America’s Best Banks” for the second consecutive year and was recently named to Forbes list of “World’s Best Banks” for the third consecutive year. Additional information about Simmons Bank can be found on our website at simmonsbank.com, by following @Simmons_Bank on Twitter or by visiting our newsroom.

Conference Call

Management will conduct a live conference call to review this information beginning at 9:00 a.m. Central Time today, Thursday, July 21, 2022. Interested persons can listen to this call by dialing toll-free 1-877-270-2148 (North America only) and asking for the Simmons First National Corporation conference call, conference ID 10168365. In addition, the call will be available live or in recorded version on the Company’s website at simmonsbank.com for at least 60 days.

Non-GAAP Financial Measures

This press release contains financial information determined by methods other than in accordance with U.S. generally accepted accounting principles (GAAP). The Company’s management uses these non-GAAP financial measures in their analysis of the Company’s performance. These measures adjust GAAP performance measures to, among other things, include the tax benefit associated with revenue items that are tax-exempt, as well as exclude from net income (including on a per share diluted basis), pre-tax, pre-provision earnings, net charge-offs, income available to common shareholders, non-interest income, and non-interest expense certain income and expense items attributable to merger activity (primarily including merger-related expenses), gains and/or losses on sale of branches, early retirement programs and net branch right-sizing initiatives. In addition, the Company also presents certain figures based on tangible common stockholders’ equity, tangible assets and tangible book value, which exclude goodwill and other intangible assets. The Company further presents certain figures that are exclusive of the impact of PPP loans, deposits and/or loans acquired through the Spirit acquisition, mortgage warehouse loans, and/or energy loans. The Company’s management believes that these non-GAAP financial measures are useful to investors because they, among other things, present the results of the Company’s ongoing operations without the effect of mergers or other items not central to the Company’s ongoing business, as well as normalize for tax effects and the effects of the PPP. Management, therefore, believes presentations of these non-GAAP financial measures provide useful supplemental information that is essential to a proper understanding of the operating results of the Company’s ongoing businesses, and management uses these non-GAAP financial measures to assess the performance of the Company’s ongoing businesses as related to prior financial periods. These non-GAAP disclosures should not be viewed as a substitute for operating results determined in accordance with GAAP, nor are they necessarily comparable to non-GAAP performance measures that may be presented by other companies. Where non-GAAP financial measures are used, the comparable GAAP financial measure, as well as the reconciliation to the comparable GAAP financial measure, can be found in the tables of this release.

Forward-Looking Statements

Certain statements in this news release may not be based on historical facts and should be considered “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements, including, without limitation, statements made in Mr. Makris’s quotes, may be identified by reference to future periods or by the use of forward-looking terminology, such as “believe,” “budget,” “expect,” “foresee,” “anticipate,” “intend,” “indicate,” “target,” “estimate,” “plan,” “project,” “continue,” “contemplate,” “positions,” “prospects,” “predict,” or “potential,” by future conditional verbs such as “will,” “would,” “should,” “could,” “might” or “may,” or by variations of such words or by similar expressions. These forward-looking statements include, without limitation, statements relating to Simmons’ future growth, lending capacity and lending activity, loan demand, revenue, assets, asset quality, profitability, dividends, net interest margin, non-interest revenue, share repurchase program, acquisition strategy, digital banking initiatives, the Company’s ability to recruit and retain key employees, the adequacy of the allowance for credit losses, the ability of the Company to manage the impacts of the COVID-19 pandemic, and the impacts of the Company’s and its customers’ participation in the PPP. Any forward-looking statement speaks only as of the date of this news release, and Simmons undertakes no obligation to update these forward-looking statements to reflect events or circumstances that occur after the date of this news release. By nature, forward-looking statements are based on various assumptions and involve inherent risk and uncertainties. Various factors, including, but not limited to, changes in economic conditions, credit quality, interest rates, loan demand, deposit flows, real estate values, the assumptions used in making the forward-looking statements, the securities markets generally or the price of Simmons’ common stock specifically, and information technology affecting the financial industry; the effect of steps the Company takes and has taken in response to the COVID-19 pandemic; the severity and duration of the COVID-19 pandemic and the heightened impact it has on many of the risks described herein; the effects of the COVID-19 pandemic on, among other things, the Company’s operations, liquidity, and credit quality; general economic and market conditions; market disruptions including pandemics or significant health hazards, severe weather conditions, natural disasters, terrorist activities, financial crises, political crises, war and other military conflicts (including the ongoing military conflict between Russia and Ukraine) or other major events, or the prospect of these events; increased competition in the markets in which the Company operates; increased unemployment; labor shortages; claims, damages, and fines related to litigation or government actions; changes in accounting principles relating to loan loss recognition (current expected credit losses); the Company’s ability to manage and successfully integrate its mergers and acquisitions and to fully realize cost savings and other benefits associated with those transactions; cyber threats, attacks or events; reliance on third parties for key services; government legislation; and other factors, many of which are beyond the control of the Company, could cause actual results to differ materially from those projected in or contemplated by the forward-looking statements. Additional information on factors that might affect the Company’s financial results is included in the Company’s Form 10-K for the year ended December 31, 2021, and other reports that the Company has filed with or furnished to the U.S. Securities and Exchange Commission (the SEC), all of which are available from the SEC on its website, www.sec.gov.

FOR MORE INFORMATION CONTACT:

Ed Bilek

EVP, Director of Investor and Media Relations

Simmons First National Corporation

ed.bilek@simmonsbank.com

205.612.3378 (cell)

Simmons First National Corporation														SFNC
Consolidated End of Period Balance Sheets
For the Quarters Ended		Jun 30			Mar 31			Dec 31			Sep 30			Jun 30
(Unaudited)		2022			2022			2021			2021			2021
($ in thousands)
ASSETS
Cash and non-interest bearing balances due from banks	$	193,473		$	195,510		$	209,190		$	225,500		$	215,381
Interest bearing balances due from banks and federal funds sold		771,374			1,491,507			1,441,463			1,555,913			2,123,743
Cash and cash equivalents		964,847			1,687,017			1,650,653			1,781,413			2,339,124
Interest bearing balances due from banks - time		1,535			1,857			1,882			1,780			1,335
Investment securities - held-to-maturity		3,819,682			1,556,825			1,529,221			1,516,797			931,352
Investment securities - available-for-sale		4,341,647			6,640,069			7,113,545			6,822,203			6,556,581
Mortgage loans held for sale		14,437			18,206			36,356			34,628			36,011
Other loans held for sale		16,375			-			100			100			100
Loans:
Loans		15,110,344			12,028,593			12,012,503			10,825,227			11,386,352
Allowance for credit losses on loans		(212,611	)		(178,924	)		(205,332	)		(202,508	)		(227,239	)
Net loans		14,897,733			11,849,669			11,807,171			10,622,719			11,159,113
Premises and equipment		553,062			486,531			483,469			463,924			429,587
Premises held for sale		-			-			-			-			6,090
Foreclosed assets and other real estate owned		4,084			5,118			6,032			11,759			15,239
Interest receivable		82,332			69,357			72,990			68,405			67,916
Bank owned life insurance		486,355			448,011			445,305			421,762			419,198
Goodwill		1,310,528			1,147,007			1,146,007			1,075,305			1,075,305
Other intangible assets		137,285			102,748			106,235			100,428			103,759
Other assets		588,707			469,853			325,793			304,707			282,449
Total assets	$	27,218,609		$	24,482,268		$	24,724,759		$	23,225,930		$	23,423,159

LIABILITIES AND STOCKHOLDERS' EQUITY
Deposits:
Non-interest bearing transaction accounts	$	6,057,186		$	5,223,862		$	5,325,318		$	4,918,845		$	4,893,959
Interest bearing transaction accounts and savings deposits		12,816,198			12,105,948			11,588,770			10,697,451			10,569,602
Time deposits		3,162,479			2,062,612			2,452,460			2,455,774			2,841,052
Total deposits		22,035,863			19,392,422			19,366,548			18,072,070			18,304,613
Federal funds purchased and securities sold under agreements to repurchase		155,101			196,828			185,403			217,276			187,215
Other borrowings		1,060,244			1,337,243			1,337,973			1,338,585			1,339,193
Subordinated notes and debentures		421,693			384,242			384,131			383,278			383,143
Other liabilities held for sale		-			-			-			-			-
Accrued interest and other liabilities		285,813			209,926			201,863			184,190			169,629
Total liabilities		23,958,714			21,520,661			21,475,918			20,195,399			20,383,793

Stockholders' equity:
Preferred stock		-			-			-			767			767
Common stock		1,288			1,125			1,127			1,066			1,084
Surplus		2,569,060			2,150,453			2,164,989			1,974,561			2,021,128
Undivided profits		1,139,975			1,136,990			1,093,270			1,065,566			1,004,314
Accumulated other comprehensive (loss) income:
Unrealized (depreciation) appreciation on AFS securities		(450,428	)		(326,961	)		(10,545	)		(11,429	)		12,073
Total stockholders' equity		3,259,895			2,961,607			3,248,841			3,030,531			3,039,366
Total liabilities and stockholders' equity	$	27,218,609		$	24,482,268		$	24,724,759		$	23,225,930		$	23,423,159

Simmons First National Corporation														SFNC
Consolidated Statements of Income - Quarter-to-Date
For the Quarters Ended		Jun 30			Mar 31			Dec 31			Sep 30			Jun 30
(Unaudited)		2022			2022			2021			2021			2021
($ in thousands, except per share data)
INTEREST INCOME
Loans (including fees)	$	163,578		$	127,176		$	137,564		$	132,216		$	138,804
Interest bearing balances due from banks and federal funds sold		1,117			649			583			763			651
Investment securities		37,848			33,712			32,275			30,717			27,128
Mortgage loans held for sale		200			190			310			230			386
Other loans held for sale		2,063			-			-			-			-
TOTAL INTEREST INCOME		204,806			161,727			170,732			163,926			166,969
INTEREST EXPENSE
Time deposits		2,875			2,503			3,705			4,747			6,061
Other deposits		6,879			4,314			4,390			4,369			4,721
Federal funds purchased and securities sold under agreements to repurchase		119			68			72			70			192
Other borrowings		4,844			4,779			4,903			4,893			4,897
Subordinated notes and debentures		4,990			4,457			4,581			4,610			4,565
TOTAL INTEREST EXPENSE		19,707			16,121			17,651			18,689			20,436
NET INTEREST INCOME		185,099			145,606			153,081			145,237			146,533
Provision for credit losses		33,859			(19,914	)		(1,308	)		(19,890	)		(12,951	)
NET INTEREST INCOME AFTER PROVISION FOR CREDIT LOSSES		151,240			165,520			154,389			165,127			159,484
NON-INTEREST INCOME
Wealth management fees		7,214			7,968			8,042			7,877			7,892
Service charges on deposit accounts		11,379			10,696			11,909			11,557			10,050
Other service charges and fees		1,871			1,637			1,762			1,964			2,048
Mortgage lending income		2,240			4,550			5,043			5,818			4,490
Debit and credit card fees		8,224			7,449			7,460			7,102			7,073
Bank owned life insurance income		2,563			2,706			2,768			2,573			2,038
(Loss) gain on sale of securities, net		(150	)		(54	)		(348	)		5,248			5,127
Other income		6,837			7,266			9,965			6,411			8,397
TOTAL NON-INTEREST INCOME		40,178			42,218			46,601			48,550			47,115
NON-INTEREST EXPENSE
Salaries and employee benefits		74,135			67,906			63,832			61,902			60,261
Occupancy expense, net		11,004			10,023			11,033			9,361			9,103
Furniture and equipment expense		5,104			4,775			4,721			4,895			4,859
Other real estate and foreclosure expense		142			343			576			339			863
Deposit insurance		2,812			1,838			2,108			1,870			1,687
Merger-related costs		19,133			1,886			13,591			1,401			686
Other operating expenses		44,483			41,646			45,736			34,565			37,198
TOTAL NON-INTEREST EXPENSE		156,813			128,417			141,597			114,333			114,657
NET INCOME BEFORE INCOME TAXES		34,605			79,321			59,393			99,344			91,942
Provision for income taxes		7,151			14,226			11,155			18,770			17,018
NET INCOME		27,454			65,095			48,238			80,574			74,924
Preferred stock dividends		-			-			8			13			13
NET INCOME AVAILABLE TO COMMON STOCKHOLDERS	$	27,454		$	65,095		$	48,230		$	80,561		$	74,911
BASIC EARNINGS PER SHARE	$	0.21		$	0.58		$	0.42		$	0.75		$	0.69
DILUTED EARNINGS PER SHARE	$	0.21		$	0.58		$	0.42		$	0.74		$	0.69

Simmons First National Corporation														SFNC
Consolidated Risk-Based Capital
For the Quarters Ended		Jun 30			Mar 31			Dec 31			Sep 30			Jun 30
(Unaudited)		2022			2022			2021			2021			2021
($ in thousands)
Tier 1 capital
Stockholders' equity	$	3,259,895		$	2,961,607		$	3,248,841		$	3,030,531		$	3,039,366
CECL transition provision (1)		92,619			92,619			114,458			122,787			128,933
Disallowed intangible assets, net of deferred tax		(1,423,323	)		(1,224,691	)		(1,226,686	)		(1,152,688	)		(1,156,203	)
Unrealized loss (gain) on AFS securities		450,428			326,961			10,545			11,429			(12,073	)
Total Tier 1 capital		2,379,619			2,156,496			2,147,158			2,012,059			2,000,023

Tier 2 capital
Subordinated notes and debentures		421,693			384,242			384,131			383,278			383,143
Qualifying allowance for loan losses and reserve for unfunded commitments		114,733			78,057			71,853			60,700			79,138
Total Tier 2 capital		536,426			462,299			455,984			443,978			462,281
Total risk-based capital	$	2,916,045		$	2,618,795		$	2,603,142		$	2,456,037		$	2,462,304

Risk weighted assets	$	19,669,149		$	15,953,622		$	15,538,967		$	14,098,320		$	14,076,975

Adjusted average assets for leverage ratio	$	25,807,113		$	23,966,206		$	23,647,901		$	22,189,921		$	22,244,118

Ratios at end of quarter
Equity to assets		11.98	%		12.10	%		13.14	%		13.05	%		12.98	%
Tangible common equity to tangible assets (2)		7.03	%		7.37	%		8.51	%		8.41	%		8.36	%
Common equity Tier 1 ratio (CET1)		12.10	%		13.52	%		13.82	%		14.27	%		14.20	%
Tier 1 leverage ratio		9.22	%		9.00	%		9.08	%		9.07	%		8.99	%
Tier 1 risk-based capital ratio		12.10	%		13.52	%		13.82	%		14.27	%		14.21	%
Total risk-based capital ratio		14.83	%		16.42	%		16.75	%		17.42	%		17.49	%

(1) The Company has elected to use the CECL transition provision allowed for in the year of adopting ASC 326.

(2) Calculations of tangible common equity to tangible assets and the reconciliations to GAAP are included in the schedules accompanying this release.

Simmons First National Corporation										SFNC
Consolidated Investment Securities
For the Quarters Ended		Jun 30		Mar 31		Dec 31		Sep 30		Jun 30
(Unaudited)		2022		2022		2021		2021		2021
($ in thousands)
Investment Securities - End of Period
Held-to-Maturity
U.S. Government agencies	$	446,789	$	232,670	$	232,609	$	232,549	$	77,396
Mortgage-backed securities		1,244,713		112,496		70,342		57,930		60,649
State and political subdivisions		1,868,924		1,194,459		1,209,051		1,209,091		793,307
Other securities		259,256		17,200		17,219		17,227		-
Total held-to-maturity (net of credit losses)		3,819,682		1,556,825		1,529,221		1,516,797		931,352
Available-for-Sale
U.S. Treasury	$	1,441	$	-	$	300	$	300	$	600
U.S. Government agencies		198,333		333,231		364,641		354,382		554,937
Mortgage-backed securities		2,963,934		4,166,108		4,448,616		4,421,620		3,987,209
State and political subdivisions		915,255		1,653,694		1,819,658		1,575,208		1,557,497
Other securities		262,684		487,036		480,330		470,693		456,338
Total available-for-sale (net of credit losses)		4,341,647		6,640,069		7,113,545		6,822,203		6,556,581
Total investment securities (net of credit losses)	$	8,161,329	$	8,196,894	$	8,642,766	$	8,339,000	$	7,487,933
Fair value - HTM investment securities	$	3,278,982	$	1,307,058	$	1,517,378	$	1,487,916	$	935,596

Investment Securities - QTD Average
Taxable securities	$	5,674,470	$	5,688,306	$	5,790,429	$	5,475,932	$	4,265,545
Tax exempt securities		2,725,610		2,844,777		2,787,301		2,496,958		2,157,076
Total investment securities - QTD average	$	8,400,080	$	8,533,083	$	8,577,730	$	7,972,890	$	6,422,621

Simmons First National Corporation										SFNC
Consolidated Loans
For the Quarters Ended		Jun 30		Mar 31		Dec 31		Sep 30		Jun 30
(Unaudited)		2022		2022		2021		2021		2021
($ in thousands)
Loan Portfolio - End of Period
Consumer
Credit cards	$	189,684	$	184,372	$	187,052	$	175,884	$	177,634
Other consumer		204,692		180,602		168,318		182,492		181,712
Total consumer		394,376		364,974		355,370		358,376		359,346
Real Estate
Construction		2,082,688		1,423,445		1,326,371		1,229,740		1,428,165
Single-family residential		2,357,942		2,042,978		2,101,975		1,540,701		1,608,028
Other commercial real estate		7,082,055		5,762,567		5,738,904		5,308,902		5,332,655
Total real estate		11,522,685		9,228,990		9,167,250		8,079,343		8,368,848
Commercial
Commercial		2,612,256		2,016,405		1,992,043		1,821,905		2,074,729
Agricultural		218,743		150,465		168,717		216,735		193,462
Total commercial		2,830,999		2,166,870		2,160,760		2,038,640		2,268,191
Other		362,284		267,759		329,123		348,868		389,967
Total loans	$	15,110,344	$	12,028,593	$	12,012,503	$	10,825,227	$	11,386,352

Simmons First National Corporation														SFNC
Consolidated Allowance and Asset Quality
For the Quarters Ended		Jun 30			Mar 31			Dec 31			Sep 30			Jun 30
(Unaudited)		2022			2022			2021			2021			2021
($ in thousands)
Allowance for Credit Losses on Loans
Beginning balance	$	178,924		$	205,332		$	202,508		$	227,239		$	235,116

Day 1 PCD allowance from acquisitions
Landmark (10/08/2021)		-						2,359
Triumph (10/08/2021)		-						11,092
Spirit of Texas (01/08/2022)		4,043						-
Total Day 1 PCD allowance		4,043						13,451

Loans charged off
Credit cards		1,004			920			865			711			1,046
Other consumer		518			414			477			463			411
Real estate		115			485			2,624			5,941			439
Commercial		688			6,319			8,513			932			309
Total loans charged off		2,325			8,138			12,479			8,047			2,205

Recoveries of loans previously charged off
Credit cards		249			274			247			267			244
Other consumer		302			387			267			408			425
Real estate		391			426			916			2,068			1,523
Commercial		621			557			1,730			463			2,147
Total recoveries		1,563			1,644			3,160			3,206			4,339
Net loans charged off		762			6,494			9,319			4,841			(2,134	)
Provision for credit losses on loans		30,406			(19,914	)		(1,308	)		(19,890	)		(10,011	)
Balance, end of quarter	$	212,611		$	178,924		$	205,332		$	202,508		$	227,239

Non-performing assets
Non-performing loans
Nonaccrual loans	$	62,670		$	64,096		$	68,204		$	59,054		$	80,282
Loans past due 90 days or more		904			240			349			334			653
Total non-performing loans		63,574			64,336			68,553			59,388			80,935
Other non-performing assets
Foreclosed assets and other real estate owned		4,084			5,118			6,032			11,759			15,239
Other non-performing assets		2,314			1,479			1,667			1,724			1,062
Total other non-performing assets		6,398			6,597			7,699			13,483			16,301
Total non-performing assets	$	69,972		$	70,933		$	76,252		$	72,871		$	97,236
Performing TDRs (troubled debt restructurings)	$	2,655		$	3,424		$	4,289		$	4,251		$	4,436

Ratios
Allowance for credit losses on loans to total loans		1.41	%		1.49	%		1.71	%		1.87	%		2.00	%
Allowance for credit losses to non-performing loans		334	%		278	%		300	%		341	%		281	%
Non-performing loans to total loans		0.42	%		0.53	%		0.57	%		0.55	%		0.71	%
Non-performing assets (including performing TDRs) to total assets		0.27	%		0.30	%		0.33	%		0.33	%		0.43	%
Non-performing assets to total assets		0.26	%		0.29	%		0.31	%		0.31	%		0.42	%
Annualized net charge offs to total loans		0.02	%		0.22	%		0.31	%		0.17	%		-0.07	%
Annualized net credit card charge offs to total credit card loans		1.55	%		1.39	%		1.29	%		0.96	%		1.78	%

Simmons First National Corporation																	SFNC
Consolidated - Average Balance Sheet and Net Interest Income Analysis
For the Quarters Ended
(Unaudited)
		Three Months Ended Jun 2022						Three Months Ended Mar 2022						Three Months Ended Jun 2021
($ in thousands)		Average Balance		Income/ Expense	Yield/ Rate			Average Balance		Income/ Expense	Yield/ Rate			Average Balance		Income/ Expense	Yield/ Rate
ASSETS
Earning assets:
Interest bearing balances due from banks and federal funds sold	$	777,098	$	1,117	0.58	%	$	1,728,694	$	649	0.15	%	$	2,703,920	$	651	0.10	%
Investment securities - taxable		5,674,470		21,794	1.54	%		5,688,306		18,148	1.29	%		4,265,545		14,594	1.37	%
Investment securities - non-taxable (FTE)		2,725,610		21,733	3.20	%		2,844,777		20,937	2.98	%		2,157,076		16,899	3.14	%
Mortgage loans held for sale		17,173		200	4.67	%		27,633		190	2.79	%		49,262		386	3.14	%
Other loans held for sale		22,114		2,063	37.42	%		-		-	0.00	%		-		-	0.00	%
Loans - including fees (FTE)		14,478,183		163,995	4.54	%		11,895,805		127,405	4.34	%		11,783,839		138,987	4.73	%
Total interest earning assets (FTE)		23,694,648		210,902	3.57	%		22,185,215		167,329	3.06	%		20,959,642		171,517	3.28	%
Non-earning assets		3,074,384						2,640,984						2,298,279
Total assets	$	26,769,032					$	24,826,199					$	23,257,921

LIABILITIES AND STOCKHOLDERS' EQUITY
Interest bearing liabilities:
Interest bearing transaction and savings accounts	$	12,807,502	$	6,879	0.22	%	$	12,083,516	$	4,314	0.14	%	$	10,403,932	$	4,721	0.18	%
Time deposits		2,586,567		2,875	0.45	%		2,241,123		2,503	0.45	%		2,930,025		6,061	0.83	%
Total interest bearing deposits		15,394,069		9,754	0.25	%		14,324,639		6,817	0.19	%		13,333,957		10,782	0.32	%
Federal funds purchased and securities sold under agreement to repurchase		210,280		119	0.23	%		218,186		68	0.13	%		240,876		192	0.32	%
Other borrowings		1,241,501		4,844	1.56	%		1,337,654		4,779	1.45	%		1,340,008		4,897	1.47	%
Subordinated notes and debentures		418,327		4,990	4.78	%		384,187		4,457	4.70	%		383,078		4,565	4.78	%
Total interest bearing liabilities		17,264,177		19,707	0.46	%		16,264,666		16,121	0.40	%		15,297,919		20,436	0.54	%
Non-interest bearing liabilities:
Non-interest bearing deposits		5,926,304						5,184,828						4,826,927
Other liabilities		216,848						207,597						151,699
Total liabilities		23,407,329						21,657,091						20,276,545
Stockholders' equity		3,361,703						3,169,108						2,981,376
Total liabilities and stockholders' equity	$	26,769,032					$	24,826,199					$	23,257,921
Net interest income (FTE)			$	191,195					$	151,208					$	151,081
Net interest spread (FTE)					3.11	%					2.66	%					2.74	%
Net interest margin (FTE) - quarter-to-date					3.24	%					2.76	%					2.89	%
Net interest margin (FTE) - year-to-date					3.01	%					2.76	%					2.94	%

Simmons First National Corporation														SFNC
Consolidated - Selected Financial Data
For the Quarters Ended		Jun 30			Mar 31			Dec 31			Sep 30			Jun 30
(Unaudited)		2022			2022			2021			2021			2021
($ in thousands, except share data)
QUARTER-TO-DATE
Financial Highlights - GAAP
Net Income	$	27,454		$	65,095		$	48,230		$	80,561		$	74,911
Diluted earnings per share		0.21			0.58			0.42			0.74			0.69
Return on average assets		0.41	%		1.06	%		0.77	%		1.37	%		1.29	%
Return on average common equity		3.28	%		8.33	%		5.87	%		10.42	%		10.08	%
Return on tangible common equity		6.28	%		14.31	%		9.98	%		17.43	%		17.25	%
Net interest margin (FTE)		3.24	%		2.76	%		2.86	%		2.85	%		2.89	%
FTE adjustment		6,096			5,602			5,579			4,941			4,548
Average diluted shares outstanding		128,720,078			113,026,911			114,491,119			108,359,890			108,822,175
Shares repurchased under plan		2,035,324			513,725			2,625,348			1,806,205			-
Average price of shares repurchased		24.57			31.25			29.69			28.48			-
Cash dividends declared per common share		0.19			0.19			0.18			0.18			0.18
Accretable yield on acquired loans		9,898			3,703			5,758			4,122			5,619
Efficiency ratio (non-GAAP) ⁽¹⁾		57.49	%		62.95	%		59.48	%		58.10	%		56.75	%

END OF PERIOD
Book value per share	$	25.31		$	26.32		$	28.82		$	28.42		$	28.03
Tangible book value per share		14.07			15.22			17.71			17.39			17.16
Shares outstanding		128,787,764			112,505,555			112,715,444			106,603,231			108,386,669
Full-time equivalent employees		3,233			2,893			2,877			2,740			2,783
Total number of financial centers		233			197			199			185			198

(1) Efficiency ratio is adjusted non-interest expense before foreclosed property expense and amortization of intangibles as a percent of net interest income (fully taxable equivalent) and non-interest revenues, excluding gains and losses from securities transactions and certain adjusting items, and is a non-GAAP measurement.

Simmons First National Corporation														SFNC
Reconciliation Of Non-GAAP Financial Measures - Adjusted Earnings - Quarter-to-Date
For the Quarters Ended		Jun 30			Mar 31			Dec 31			Sep 30			Jun 30
(Unaudited)		2022			2022			2021			2021			2021
($ in thousands, except per share data)
QUARTER-TO-DATE
Net Income	$	27,454		$	65,095		$	48,230		$	80,561		$	74,911
Certain items
Gain on sale of branches		-			-			-			-			(16	)
Merger-related costs		19,133			1,886			13,591			1,401			686
Branch right-sizing (net)		380			909			1,648			(3,041	)		39
Day 2 CECL provision		33,779			-			22,688			-
Tax effect ⁽¹⁾		(13,928	)		(731	)		(9,912	)		429			(185	)
Certain items, net of tax		39,364			2,064			28,015			(1,211	)		524
Adjusted earnings (non-GAAP)	$	66,818		$	67,159		$	76,245		$	79,350		$	75,435

Diluted earnings per share	$	0.21		$	0.58		$	0.42		$	0.74		$	0.69
Certain items
Gain on sale of branches		-			-			-			-			-
Merger-related costs		0.15			0.01			0.12			0.01			0.01
Branch right-sizing (net)		-			0.01			0.01			(0.03	)		-
Day 2 CECL provision		0.27						0.20
Tax effect ⁽¹⁾		(0.11	)		(0.01	)		(0.09	)		0.01			(0.01	)
Certain items, net of tax		0.31			0.01			0.24			(0.01	)		-
Adjusted diluted earnings per share (non-GAAP)	$	0.52		$	0.59		$	0.66		$	0.73		$	0.69

(1) Effective tax rate of 26.135%.

Reconciliation of Certain Adjusting Non-Interest Income and Expense Items (non-GAAP)

QUARTER-TO-DATE
Other income	$	6,837		$	7,266		$	9,965		$	6,411		$	8,397
Adjusting items ⁽¹⁾		88			-			(2	)		239			(445	)
Adjusted other income (non-GAAP)	$	6,925		$	7,266		$	9,963		$	6,650		$	7,952

Non-interest expense	$	156,813		$	128,417		$	141,597		$	114,333		$	114,657
Adjusting items ⁽¹⁾		(19,425	)		(2,795	)		(15,241	)		1,879			(1,154	)
Adjusted non-interest expense (non-GAAP)	$	137,388		$	125,622		$	126,356		$	116,212		$	113,503

Salaries and employee benefits	$	74,135		$	67,906		$	63,832		$	61,902		$	60,261
Adjusting items ⁽¹⁾		-			-			-			(66	)		-
Adjusted salaries and employee benefits (non-GAAP)	$	74,135		$	67,906		$	63,832		$	61,836		$	60,261

Other operating expenses	$	44,483		$	41,646		$	45,736		$	34,565		$	37,198
Adjusting items ⁽¹⁾		(7	)		(717	)		96			3,759			(89	)
Adjusted other operating expenses (non-GAAP)	$	44,476		$	40,929		$	45,832		$	38,324		$	37,109

(1) Adjusting items include gain on sale of branches, merger related costs and branch right-sizing costs.

Simmons First National Corporation														SFNC
Reconciliation Of Non-GAAP Financial Measures - End of Period
For the Quarters Ended		Jun 30			Mar 31			Dec 31			Sep 30			Jun 30
(Unaudited)		2022			2022			2021			2021			2021
($ in thousands, except per share data)

Calculation of Tangible Common Equity and the Ratio of Tangible Common Equity to Tangible Assets

Total common stockholders' equity	$	3,259,895		$	2,961,607		$	3,248,841		$	3,029,764		$	3,038,599
Intangible assets:
Goodwill		(1,310,528	)		(1,147,007	)		(1,146,007	)		(1,075,305	)		(1,075,305	)
Other intangible assets		(137,285	)		(102,748	)		(106,235	)		(100,428	)		(103,759	)
Total intangibles		(1,447,813	)		(1,249,755	)		(1,252,242	)		(1,175,733	)		(1,179,064	)
Tangible common stockholders' equity	$	1,812,082		$	1,711,852		$	1,996,599		$	1,854,031		$	1,859,535

Total assets	$	27,218,609		$	24,482,268		$	24,724,759		$	23,225,930		$	23,423,159
Intangible assets:
Goodwill		(1,310,528	)		(1,147,007	)		(1,146,007	)		(1,075,305	)		(1,075,305	)
Other intangible assets		(137,285	)		(102,748	)		(106,235	)		(100,428	)		(103,759	)
Total intangibles		(1,447,813	)		(1,249,755	)		(1,252,242	)		(1,175,733	)		(1,179,064	)
Tangible assets	$	25,770,796		$	23,232,513		$	23,472,517		$	22,050,197		$	22,244,095

Paycheck protection program ("PPP") loans		(19,476	)		(61,887	)		(116,659	)		(212,087	)		(441,353	)
Total assets excluding PPP loans	$	27,199,133		$	24,420,381		$	24,608,100		$	23,013,843		$	22,981,806
Tangible assets excluding PPP loans	$	25,751,320		$	23,170,626		$	23,355,858		$	21,838,110		$	21,802,742

Ratio of common equity to assets		11.98	%		12.10	%		13.14	%		13.04	%		12.97	%
Ratio of common equity to assets excluding PPP loans		11.99	%		12.13	%		13.20	%		13.16	%		13.22	%
Ratio of tangible common equity to tangible assets		7.03	%		7.37	%		8.51	%		8.41	%		8.36	%
Ratio of tangible common equity to tangible assets excluding PPP loans		7.04	%		7.39	%		8.55	%		8.49	%		8.53	%

Calculation of Tangible Book Value per Share

Total common stockholders' equity	$	3,259,895		$	2,961,607		$	3,248,841		$	3,029,764		$	3,038,599
Intangible assets:
Goodwill		(1,310,528	)		(1,147,007	)		(1,146,007	)		(1,075,305	)		(1,075,305	)
Other intangible assets		(137,285	)		(102,748	)		(106,235	)		(100,428	)		(103,759	)
Total intangibles		(1,447,813	)		(1,249,755	)		(1,252,242	)		(1,175,733	)		(1,179,064	)
Tangible common stockholders' equity	$	1,812,082		$	1,711,852		$	1,996,599		$	1,854,031		$	1,859,535
Shares of common stock outstanding		128,787,764			112,505,555			112,715,444			106,603,231			108,386,669
Book value per common share	$	25.31		$	26.32		$	28.82		$	28.42		$	28.03
Tangible book value per common share	$	14.07		$	15.22		$	17.71		$	17.39		$	17.16

Simmons First National Corporation														SFNC
Reconciliation Of Non-GAAP Financial Measures - Quarter-to-Date
For the Quarters Ended		Jun 30			Mar 31			Dec 31			Sep 30			Jun 30
(Unaudited)		2022			2022			2021			2021			2021
($ in thousands)
Calculation of Efficiency Ratio ⁽¹⁾

Non-interest expense	$	156,813		$	128,417		$	141,597		$	114,333		$	114,657
Non-interest expense adjustment		(19,425	)		(2,795	)		(15,241	)		1,879			(1,154	)
Other real estate and foreclosure expense adjustment		(142	)		(343	)		(576	)		(339	)		(863	)
Amortization of intangibles adjustment		(4,096	)		(3,486	)		(3,486	)		(3,331	)		(3,333	)
Efficiency ratio numerator	$	133,150		$	121,793		$	122,294		$	112,542		$	109,307

Net-interest income	$	185,099		$	145,606		$	153,081		$	145,237		$	146,533
Non-interest income		40,178			42,218			46,601			48,550			47,115
Non-interest income adjustment		88			-			(2	)		239			(445	)
Fully tax-equivalent adjustment (effective tax rate of 26.135%)		6,096			5,602			5,579			4,941			4,548
Loss (gain) on sale of securities		150			54			348			(5,248	)		(5,127	)
Efficiency ratio denominator	$	231,611		$	193,480		$	205,607		$	193,719		$	192,624

Efficiency ratio ⁽¹⁾		57.49	%		62.95	%		59.48	%		58.10	%		56.75	%

Simmons First National Corporation														SFNC
Reconciliation Of Non-GAAP Financial Measures - Quarter-to-Date (continued)
For the Quarters Ended		Jun 30			Mar 31			Dec 31			Sep 30			Jun 30
(Unaudited)		2022			2022			2021			2021			2021
($ in thousands)
Calculation of Adjusted Net Interest Margin

Net interest income	$	185,099		$	145,606		$	153,081		$	145,237		$	146,533
Fully tax-equivalent adjustment (effective tax rate of 26.135%)		6,096			5,602			5,579			4,941			4,548
Fully tax-equivalent net interest income		191,195			151,208			158,660			150,178			151,081
PPP loan interest income		(1,648	)	$	(2,113	)	$	(5,107	)	$	(9,614	)	$	(8,958	)
Net interest income adjusted for PPP loans	$	189,547		$	149,095		$	153,553		$	140,564		$	142,123

Average earning assets	$	23,694,648		$	22,185,215		$	22,029,792		$	20,901,992		$	20,959,642
Average PPP loan balance		(43,329	)		(89,757	)		(172,130	)		(359,828	)		(707,296	)
Average earning assets adjusted for PPP loans	$	23,651,319		$	22,095,458		$	21,857,662		$	20,542,164		$	20,252,346

Net interest margin		3.24	%		2.76	%		2.86	%		2.85	%		2.89	%
Net interest margin adjusted for PPP loans		3.21	%		2.74	%		2.79	%		2.71	%		2.81	%

Calculation of Pre-Provision Net Revenue (PPNR)

Net interest income	$	185,099		$	145,606		$	153,081		$	145,237		$	146,533
Non-interest income		40,178			42,218			46,601			48,550			47,115
Less: Gain (loss) on sale of securities		(150	)		(54	)		(348	)		5,248			5,127
Less: Non-interest expense		156,813			128,417			141,597			114,333			114,657
Pre-Provision Net Revenue (PPNR)	$	68,614		$	59,461		$	58,433		$	74,206		$	73,864

Calculation of Adjusted Pre-Provision Net Revenue

Pre-Provision Net Revenue (PPNR)	$	68,614		$	59,461		$	58,433		$	74,206		$	73,864
Less: Gain on sale of branches		-			-			-			-			(16	)
Plus: Merger related costs		19,133			1,886			13,591			1,401			686
Plus: Branch right sizing costs		380			909			1,648			(3,041	)		39
Adjusted Pre-Provision Net Revenue	$	88,127		$	62,256		$	73,672		$	72,566		$	74,573

Exhibit 99.2

Nasdaq: SFNC 2 nd Quarter 2022 Earnings Presentation Contents 3 Q2 Highlights 4 Q2 Results Overview 11 Loans 14 Deposits, Liquidity, Securities, Interest Rate Sensitivity & Capital 20 Credit Quality 23 Key Takeaways 25 Appendix

2 Forward - Looking Statements . Certain statements by Simmons First National Corporation (the “Company”, which where appropriate includes the Company’s wholly - owned banking subsidiary, Simmons Bank) contained in this presentation may not be based on historical facts and should be considered "forward - looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 . These forward - looking statements may be identified by reference to a future period(s) or by the use of forward - looking terminology, such as "anticipate," “continue,” "estimate," "expect," "foresee,“ “indicate,” “plan,” “potential,” “project,” “target,” "may," "might," "will," "would," "could,“ “should,” “likely” or "intend," future or conditional verb tenses, and variations or negatives of such terms or by similar expressions . These forward - looking statements include, without limitation, those relating to the Company’s future growth ; product development ; revenue ; expenses (including interest expense and non - interest expenses) ; assets ; loan demand (including loan growth and other lending activity) ; asset quality ; profitability ; earnings ; critical accounting policies ; accretion ; net interest margin ; noninterest revenue ; market conditions related to and impact of the Company's common stock repurchase program ; adequacy of the allowance for loan losses ; income tax deductions ; credit quality ; level of credit losses from lending commitments ; net interest revenue ; interest rate sensitivity (including, among other things, the potential impact of rising rates) ; loan loss experience ; liquidity ; capital resources ; economic conditions and market risk ; the expected benefits, milestones, timelines, and costs (and the anticipated realization of expected cost savings) associated with the Company’s merger and acquisition strategy and activity ; the Company’s ability to recruit and retain key employees ; the ability of the Company to manage the impacts of the COVID - 19 pandemic ; the impacts of the Company’s and its customers participation in the Paycheck Protection Program (“PPP”) ; increases in the Company’s security portfolio ; legal and regulatory limitations and compliance and competition ; anticipated loan principal reductions ; fees associated with the PPP ; plans for investments in securities ; projections and estimates associated with the Company’s acquisition of Spirit of Texas Bancshares, Inc . (“Spirit”) noted on slide 5 ; and projected dividends . Readers are cautioned not to place undue reliance on the forward - looking statements contained in this presentation in that actual results could differ materially from those indicated in or implied by such forward - looking statements, due to a variety of factors . These factors include, but are not limited to, changes in the Company's operating or expansion strategy ; the availability of and costs associated with obtaining adequate and timely sources of liquidity ; the ability to maintain credit quality ; the effect of steps the Company takes in response to the COVID - 19 pandemic ; the severity and duration of the pandemic, including the effectiveness of “booster” vaccination efforts and developments with respect to COVID - 19 variants ; the pace of recovery when the pandemic subsides and the heightened impact it has on many of the risks described herein ; the effects of the pandemic on, among other things, the Company’s operations, liquidity, and credit quality ; general market and economic conditions ; unemployment ; possible adverse rulings, judgments, settlements and other outcomes of pending or future litigation ; the ability of the Company to collect amounts due under loan agreements ; changes in consumer preferences and loan demand ; effectiveness of the Company's interest rate risk management strategies ; laws and regulations affecting financial institutions in general or relating to taxes ; the effect of pending or future legislation ; the ability of the Company to repurchase its common stock on favorable terms ; the ability of the Company to successfully manage and implement its acquisition strategy and integrate acquired institutions ; difficulties and delays in integrating an acquired business or fully realizing cost savings and other benefits of mergers and acquisitions (including Spirit) ; changes in interest rates, deposit flows, real estate values, and capital markets ; inflation ; customer acceptance of the Company's products and services ; changes or disruptions in technology and IT systems (including cyber threats, attacks and events) ; changes in accounting principles relating to loan loss recognition (current expected credit losses, or CECL) ; the benefits associated with the Company’s early retirement program ; political crises, war, and other military conflicts (including the ongoing military conflict between Russia and Ukraine) or other major events, or the prospect of these events ; increased competition ; and other risk factors . Other relevant risk factors may be detailed from time to time in the Company's press releases and filings with the U . S . Securities and Exchange Commission, including, without limitation, the Company’s Form 10 - K for the year ended December 31 , 2021 . Any forward - looking statement speaks only as of the date of this presentation, and the Company undertakes no obligation to update these forward - looking statements to reflect events or circumstances that occur after the date of this presentation . Annualized, pro forma, projected and estimated numbers are used for illustrative purpose only, are not forecasts and may not reflect actual results . Non - GAAP Financial Measures . This presentation contains financial information determined by methods other than in accordance with U . S . generally accepted accounting principles (“GAAP”) . The Company’s management uses these non - GAAP financial measures in their analysis of the Company’s performance . These measures adjust GAAP performance measures to, among other things, include the tax benefit associated with revenue items that are tax - exempt, as well as exclude from net income (including on a per share diluted basis), pre - tax, pre - provision earnings, net charge - offs, income available to common shareholders, non - interest income, and non - interest expense certain income and expense items attributable to merger activity (primarily including merger - related expenses), gains and/or losses on sale of branches, early retirement programs and net branch right - sizing initiatives . In addition, the Company also presents certain figures based on tangible common stockholders’ equity, tangible assets and tangible book value, which exclude goodwill and other intangible assets . The Company further presents certain figures that are exclusive of the impact of PPP loans, deposits and/or loans acquired through the Spirit acquisition, mortgage warehouse loans, and/or energy loans . The Company’s management believes that these non - GAAP financial measures are useful to investors because they, among other things, present the results of the Company’s ongoing operations without the effect of mergers or other items not central to the Company’s ongoing business, as well as normalize for tax effects and the effects of the PPP . Management, therefore, believes presentations of these non - GAAP financial measures provide useful supplemental information that is essential to a proper understanding of the operating results of the Company’s ongoing businesses, and management uses these non - GAAP financial measures to assess the performance of the Company’s ongoing businesses as related to prior financial periods . These non - GAAP disclosures should not be viewed as a substitute for operating results determined in accordance with GAAP, nor are they necessarily comparable to non - GAAP performance measures that may be presented by other companies . Where non - GAAP financial measures are used, the comparable GAAP financial measure, as well as the reconciliation to the comparable GAAP financial measure, can be found in the appendix to this presentation . Forward - Looking Statements and Non - GAAP Financial Measures

3 Q2 22 Highlights Total revenue in Q 2 $225.4M +20% linked quarter 1 Net interest income in Q 2 $185.1M +27% linked quarter 1 Q 2 results include significant increase in revenue . Reported EPS was $ 0 . 21 , including Day 2 CECL provision and merger related costs . Adjusted EPS ( 1 ) totaled $ 0 . 52 Positive operating leverage +15 % PPNR (1) vs Q1 Adjusted PPNR (1) up 42% 2 Positive operating leverage driven by revenue growth and well contained operating expense growth . Noninterest expense up 22 % ; excluding merger related costs and certain other items, adjusted noninterest expense up 9 % Revenue growth, excellent expense control leads to 57.5 % efficiency ratio (1) Total loans increase $3.1B vs Q1 +27% LQA (excluding Spirit (1) ) 3 Increase in net interest income fueled by strong balance sheet growth, led by organic loan growth and loans acquired from Spirit . Net interest margin up 48 bps in the quarter, while cost of deposits held to 4 bp increase Total deposits increase $2.6B vs Q1 Loan to deposit ratio at 69% NPL Ratio declines 11 bps vs Q1 NPAs to assets at 26 bps 4 Credit quality metrics reflect continued commitment to strong underwriting standards and strategic decision in 2019 to de - risk the loan portfolio through planned run - off of acquired non - relationship credits Net charge - off ratio 0.02% for Q2 ACL to loans at 1.41% (1) Non - GAAP measures that management believes aids in the discussion of results. See Appendix for Non - GAAP reconciliation LQA – linked quarter annualized growth in total loans, excluding loans acquired in Spirit transaction. Non - GAAP measure that man agement believes aids in the discussion of results. See appendix for Non - GAAP reconciliation Total revenue, as presented above, excludes gain (loss) on sale of securities

Q2 22 Results Overview

5 Spirit: Completed acquisition of Spirit of Texas Bancshares, Inc. on April 8 and immediately converted systems Acquired Spirit Balances (4) Total Securities: (1) Estimates provided at announcement on November 19, 2021 (2) Actual information following closing of transaction on April 8, 2022 (3) TBV share dilution, ’23 EPS accretion and TBV earnback are projections as of 6/30/22 (4) Spirit figures represent balances acquired upon closing, net of fair value adjustments $0.3 billion Total Loans: $2.3 billion Total Deposits: $2.7 billion Cash & Cash Equivalents: $0.3 billion Spirit Acquisition Metrics Update TBV share dilution (3.0)% ’23 EPS accretion High single digit Shares issued 18.325 million Metric At Announcement (1) Updated 18.275 million (2) (2.65)% (2) Exceeding original estimate (3) TBV Earnback ~2.8 yrs ~ 2.5 yrs (3) Oklahoma City Dallas Austin Wichita Jefferson City Kansas City St. Louis Knoxville Chattanooga OK AR TX TN MO KS Nashville Memphis Tulsa Little Rock San Antonio Houston Current projections of ’23 EPS accretion and TBV Earnback compare favorably to announcement date projections

6 Q2 22 Financial Highlights Note: Numbers may not add due to rounding NM – not meaningful Total revenue, as presented above, excludes gain (loss) on sale of securities (1) During 2021, certain debit and credit card transaction fees were reclassified from noninterest expense to noninterest i nco me under the caption debit and credit card fees. Prior periods have been adjusted to reflect this reclassification (2) Effective tax rate of 26.135% (3) Non - GAAP measures that management believes aids in the discussion of results. See appendix for Non - GAAP reconciliation Summary Income Statement $ in millions, except per share data Q2 22 Q1 22 Q2 21 Q1 22 Q2 21 Net interest income 185.1 145.6 146.5 27 26 Noninterest income (1) 40.3 42.3 42.0 (5) (4) Total revenue 225.4 187.9 188.5 20 20 Noninterest expense (1) 156.8 128.4 114.7 22 37 Pre-provision net revenue (3) 68.6 59.5 73.9 15 (7) Gain (loss) on sale of securities (0.2) (0.1) 5.1 NM NM Provision for (recapture of) credit losses on loans 33.9 (19.9) (13.0) NM NM Provision for income taxes 7.2 14.2 17.0 (50) (58) Net income $ 27.5 $ 65.1 $ 74.9 (58) % (63)% Diluted EPS $ 0.21 $ 0.58 $ 0.69 (64) % (70)% Impact of certain items: Day 2 CECL provision $ 33.8 $ - $ - Merger related costs 19.1 1.9 0.7 Branch right sizing costs 0.4 0.9 - Tax effect (2) (14.0) (0.7) (0.2) Total impact on earnings $ 39.3 $ 2.1 $ 0.5 Adjusted pre-provision net revenue (3) $ 88.1 $ 62.3 $ 74.6 42 % 18 % Adjusted net income (3) $ 66.8 $ 67.2 $ 75.4 - (11)% Adjusted diluted EPS (3) $ 0.52 $ 0.59 $ 0.69 (12) (25)% % Change vs Increase in revenue on a linked quarter basis Q2 Highlights +20% Driven by acquisition of Spirit, solid legacy SFNC net interest income growth and net interest margin expansion Excellent expense control While noninterest expense on a reported basis were up 22%, excluding merger related costs and certain other items, adjusted noninterest expenses (3) increased 9% Positive operating leverage Pre - provision net revenue (PPNR) (3) up 15% Excluding merger related costs and certain other items, adjusted PPNR (3) was up 42% Revenue growth coupled with well - contained operating expense growth fuels marked improvement in the efficiency ratio (3) to 57.5% Adjusted diluted EPS (3) of $0.52

7 Net Interest Income and Margin PPP – Paycheck Protection Program FTE – Fully taxable equivalent $151.1 $150.2 $158.7 $151.2 $191.2 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Net Interest Income $ in millions; FTE +27% Δ in Interest Income (FTE) ex PPP & Accretion Δ in Interest Expense Δ in Accretion & PPP Contribution Net Interest Income Evolution $ in millions; FTE Net Interest Margin FTE (%) 2.89 2.85 2.86 2.76 3.24 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 4.73 4.76 4.58 4.34 4.54 1.97 1.77 1.74 1.86 2.08 0.24 0.20 0.17 0.14 0.18 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Loan Yield (FTE) Securities (FTE) Cost of Deposits Loan, Securities & Deposits Yield/Rate FTE (%) Q2 Highlights The significant increase in net interest income and net interest margin on a linked quarter basis was primarily due to: • Strong balance sheet growth led by a +26% increase in loans • +48 bps increase in net interest margin, led by increased volume, +20 bps increase in loan yield and +22 bps increase securities yield • Period end loan balance of $15.1 billion vs average balance for the quarter of $14.5 billion provides a platform for interest income growth going forward Offset in part by: • $3.6 million increase in interest expense • +4 bps increase in cost of deposits Q1 22 Q2 22 +26% +48 bps +20 bps +4 bps

24.3% 25.1% 23.3% 22.5% 17.8% 22.1% 23.1% 23.5% 22.5% 17.9% Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Noninterest Income/Total Revenue Adjusted Noninterest Income /Total Revenue(2) Noninterest Income to Total Revenue $16.9 $17.7 $16.2 $14.6 $12.4 $14.9 $15.9 $16.3 $14.6 $12.5 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Noninterest Income per Employee Adjusted Noninterest Income per Employee(2) Noninterest Income Per Employee (FTE) $69.6 $70.7 $69.4 $64.9 $69.7 $67.6 $68.9 $69.5 $64.9 $69.8 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Revenue per Employee Adjusted Revenue per Employee(2) Revenue Per Employee (FTE) 8 Noninterest Income Note: Numbers may not add due to rounding NM – not meaningful FTE – Full - time equivalent (1) During 2021, certain debit and credit card transaction fees were reclassified from noninterest expense to noninterest i nco me under the caption debit and credit card fees. Prior periods have been adjusted to reflect this reclassification (2) Non - GAAP measures that management believes aids in the discussion of results. See appendix for Non - GAAP reconciliation $ in millions Q2 22 Q1 22 Q2 21 Q1 22 Q2 21 Service charges on deposit accounts $11.4 $10.7 $ 10.1 6 % 13 % Wealth management fees 7.2 8.0 7.9 (9) (9) Debit and credit card fees (1) 8.2 7.4 7.1 10 16 Mortgage lending income 2.2 4.6 4.5 (51) (50) Bank owned life insurance 2.6 2.7 2.0 (5) 26 Other service charges and fees 1.9 1.6 2.0 14 (9) Other 6.8 5.9 8.4 17 (19) 40.3 40.9 42.0 (1) (4) Settlement award - 1.4 - NM - Gain (loss) on sale of securities (0.2) (0.1) 5.1 NM NM Total noninterest income $40.2 $42.2 $47.1 (5) % (15)% Adjusted noninterest income (2) $40.4 $42.3 $41.5 (4) % (3)% % Change vs Q2 Highlights • Noninterest income for Q 2 22 was $ 40 . 2 million, compared to $ 42 . 2 million in Q 1 22 • Included in Q 1 22 results was a settlement award totaling $ 1 . 4 million . Excluding this item, noninterest income declined 1 % on a linked quarter basis • Consistent with industry trends, and as expected, the decline in mortgage lending income reflected volatility in interest rates and softening market conditions • Decline in wealth management fees driven by increased market volatility • These declines were offset, in part, by an increase in debit and credit card fees and service charges on deposit accounts, that were aided by the acquisition of Spirit

2,783 2,740 2,877 2,893 3,233 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Employees (FTE) 56.75% 58.10% 59.48% 62.95% 57.49% Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Efficiency Ratio (2) 1.97% 1.97% 2.29% 2.07% 2.34% 1.95% 2.00% 2.05% 2.02% 2.05% Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Noninterest Expense Adjusted Noninterest Expense (2) Noninterest Expense as a Percentage of Total Average Assets $ in millions Q2 22 Q1 22 Q2 21 Q1 22 Q2 21 Salaries and employee benefits $74.1 $67.9 $60.3 9 % 23 % Occupancy expense, net 11.0 10.0 9.1 10 21 Furniture and equipment 5.1 4.8 4.9 7 5 Deposit insurance 2.8 1.8 1.7 53 67 OREO and foreclosure expense 0.1 0.3 0.9 (59) (84) Contribution to Simmons First Foundation 1.6 - - NM NM Other (1) 42.9 41.6 37.2 3 15 Merger related costs 19.1 1.9 0.7 NM NM Total noninterest expense $156.8 $128.4 $114.7 22 % 37 % Adjusted noninterest expense (2) $137.4 $125.6 $113.5 9 % 21 % % Change vs 9 Noninterest Expense Note: Numbers may not add due to rounding NM – not meaningful (1) During 2021, certain debit and credit card transaction fees were reclassified from noninterest expense to noninterest i nco me under the caption debit and credit card fees. Prior periods have been adjusted to reflect this reclassification (2) Non - GAAP measures that management believes aids in the discussion of results. See appendix for Non - GAAP reconciliation Q2 Highlights • Linked quarter comparison is impacted by the acquisition of Spirit, while year - over - year comparisons are impacted by Spirit, as well as the acquisitions of Landmark Community Bank and Triumph Bancshares, Inc . , which closed in Q 4 21 . • Total noninterest expense on a linked quarter basis increased 22 % . Excluding merger related costs and certain other items, adjusted expenses increased 9 % linked quarter • Q 2 includes a $ 1 . 6 million contribution to the Simmons First Foundation Conservation Fund . Contribution reflects strategic decision to encourage customers to enroll in eStatements to avoid a paper statement fee . During a one - year period, Simmons is donating a portion of fees collected to the foundation • Improvement in efficiency ratio driven by strong revenue growth, coupled with excellent expense control • Adjusted noninterest expense in - line with goal of 2 % of average assets • Increase in employees (FTE) includes the acquisition of Spirit

Digital: An opportunity to attract the largest generation of the population Zelle and Zelle related marks are wholly owned by Early Warning Services, LLC and are used herein under license * Adjusted to addressable portion of the Gen Z population (Age 18+) Source: Internal company research Q1 22 Q2 22 Branch Transactions Digital Transactions Customer Transactions by Channel 67% 70% 69% Q1 22 Q2 22 Mobile Deposit Transactions Q1 22 Q2 22 Mobile Deposit Dollars Q4 21 Q1 22 Q2 22 Zelle ® Volume (transactions) 66% 70% Digital +12% +17% +14% +59% +50% M 1M 2M 3M 4M 5M 2020 US Population by Age and Generation 0 1000 2000 3000 4000 5000 6000 7000 M 1M 2M 3M 4M 5M Population in Millions GEN Z* 30.5M MILLENIALS 82.2M GEN X 65.1M BABY BOOMERS 68.7M SILENT GEN 23.6M GREATEST GEN 1.8M Born in: Age: 2004 18 1996 21 1981 39 1965 55 1946 74 1928 92 1916 104 Community Bank Customer Age Distribution The “GAP” Simmons Bank: recognized for leading - edge digital capabilities Launched Coin Savings on July 11 Coin Checking was made for mobile — scan the code with your phone to get started. Early Payday Designed for today's digital world. 10

Loan Portfolio

$2,130 $2,254 $2,943 $3,428 $4,473 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Unfunded Commitments $ in millions Mortgage Warehouse and PPP Agricultural 12 Loan portfolio: Loan growth driven by increased activity throughout our footprint and Spirit (1) Represents loans acquired from Spirit upon closing, net of fair value adjustments (2) Does not include Spirit PPP – Paycheck Protection Program Total loans at 6/30/22 Total loans at 3/31/22 Spirit (1) $(42) $69 $122 $315 $638 $660 $1,319 $3,081 Linked Quarter Loan Growth/(Decline ) $ in millions Total Loans RE - Commercial RE - Construction Commercial RE – Single Family +31% +16% Loan Growth by Core Banking Units Linked quarter percent change Metro Banking Community Banking Corporate Banking +14% Loan Portfolio Waterfall $ in millions New producers added in 2022 (2) 22 commercial and community bankers Consumer & Other +37% +26% +6% +30% Funded loan /advances Paydowns /payoffs +26%

+102 bps Q2 Highlights – Commercial Loan Pipeline • Commercial loan pipeline reflects continued growth across the footprint, as well as the positive impact from the acquisition of Spirit • Total commercial pipeline up 28 % vs Q 1 22 • Loans ready to close up + 44 % vs Q 1 22 • Rate ready to close at 4 . 45 % , up + 102 bps vs Q 1 22 $247 $487 $340 $503 $766 $750 $824 $250 $408 $484 $484 $929 $838 $1,077 $177 $285 $467 $493 $619 $776 $1,114 Q4 20 Q1 21 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Opportunity Proposal Ready to Close $1,291 $1,480 $2,314 $2,364 $3,015 13 Loan pipelines: 7 th consecutive quarter of increased activity in commercial loan pipeline PPP – Paycheck Protection Program (1) Quarterly amounts adjusted for Illinois branches sold in 2021 Rate Ready to Close 4.12% 3.81% 3.77% 3.47% 3.28% 3.43% 4.45% Commercial Loan Pipeline by Category (1) $ in millions +44% $399 $326 $274 $242 $291 $219 $223 $214 $166 $120 $97 $108 $99 $58 Q4 20 Q1 21 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Mortgage Closed Loan Volume Mortgage Pipeline Volume Mortgage Loan Volume $ in millions $674 $1,180 Q2 Highlights – Mortgage Loan Volume • Mortgage originations in Q 2 22 • 81 % purchase • 19 % refinance • Results consistent with industry trends reflecting current market conditions that will likely be further impacted by volatility in interest rates, inventory levels, material and labor costs, etc … +28%

Deposits, Liquidity, Securities, Interest Rate Sensitivity and Capital

0.44% 0.39% 0.34% 0.30% 0.24% 0.20% 0.17% 0.14% 0.18% 0.00% 0.05% 0.10% 0.15% 0.20% 0.25% 0.30% 0.35% 0.40% 0.45% 0.50% $0.0 $2.5 $5.0 $7.5 $10.0 $12.5 $15.0 $17.5 $20.0 $22.5 Q2 20 Q3 20 Q4 20 Q1 21 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Noninterest Bearing Interest Bearing Transactions Time Deposits Cost of Deposits $16.6 $16.2 $17.0 $18.2 $18.3 15 Deposits: 14% increase in total deposits while effectively managing rate environment Note: Numbers may not add due to rounding $ in billions As a % of Total Deposits Q2 20 Q3 20 Q4 20 Q1 21 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Noninterest Bearing 27.7% 27.4% 26.4% 26.9% 26.7% 27.2% 27.5% 27.0% 27.5% Interest Bearing Transaction Accounts 54.0% 55.4% 56.9% 56.5% 57.7% 59.2% 59.8% 62.4% 58.2% Time Deposits 18.2% 17.2% 16.7% 16.6% 15.5% 13.6% 12.7% 10.6% 14.4% $18.1 $19.4 $19.4 Deposit Mix ~86% of deposits Q2 Highlights • Total deposits increased $2.6 billion linked quarter, or 14% • The increase in deposits was driven by the acquisition of Spirit. Excluding Spirit, total deposits were flat linked quarter • ~86% of total deposits are low - cost transaction accounts, with noninterest bearing deposits representing almost 28% of total deposits • Effectively managed challenging rising rate environment during the quarter with costs of deposits rising 4 bps $22.0

16 Liquidity: Loan to deposit ratio up to 69% while maintaining solid liquidity position Cash and Cash Equivalents + Variable Rate Securities $ in millions Q4 19 Q1 20 Q2 20 Q3 20 Q4 20 Q1 21 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Cash & Cash Equivalents Variable Rate Securities $1,052 $1,792 $2,600 $2,577 $3,527 $4,103 $3,606 $3,286 $3,150 $3,132 $2,321 Loan to Deposit Ratio (1) 90% 76% 67% 62% 60% 62% 62% 69% 2019 2020 Q1 21 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 At June 30, 2022 Par Value Yield (FTE) (2) Effective Duration AFS HTM Fixed Rate MBS/CMO $3,035 1.97% 4.96 60% 40% Municipal 2,994 3.16 11.99 37 63 Treasury/Agency 581 2.35 9.18 17 83 Corporate 471 3.85 4.68 42 58 Other 188 3.41 4.52 51 49 Variable Rate 1,356 1.35 0.70 100 - Total $ 8 , 625 2.44% 6.65 54% 46% Securities Portfolio Summary $ in millions 55% 34% 3% 6% 3% MBS/CMO Municipal Treasury/Agency Corporate Other AFS Portfolio – Fixed Rate Breakout Q2 Highlights • Solid liquidity as cash position returns to more normalized level, aided by variable rate securities • Securities portfolio reflects addition of Spirit portfolio and reinvestment of cash flows into similar securities • Strategic decision to transfer approximately $ 2 billion of available - for - sale securities to held - to maturity during the quarter . Unrealized loss recorded as adjustment to accumulated other comprehensive income • Nominal change in effective duration - from 6 . 42 at 3 / 31 / 22 to 6 . 65 at 6 / 30 / 22 – while effective yield + 60 bps • Including $ 1 B matched swap on fixed rate securities, effective duration is 6 . 0 at 6 / 30 / 22 (1) As of December 31, for each respective year shown above and at the end of the quarter for each respective quarter shown ab ove (2) Effective yield of securities portfolio at 6/30/22, excludes AOCI impact of HTM transfer during Q2 22 FTE – fully taxable equivalent

17 Interest Rate Sensitivity Balance Sheet Interest Rate Sensitivity Over the next 12 months (estimated) 2.88% 5.33% 7.74% +100 bps +200 bps +300 bps Net interest income sensitivity given immediate, parallel shift in interest rates across the yield curve with a static balance sheet Immediate increase in interest rates 2.40% 4.11% 5.72% +100 bps +200 bps +300 bps Gradual increase in interest rates Loan Portfolio At June 30, 2022 45% 55% Variable Rate Loans Fixed Rate Loans Fixed vs Variable Rate 5% 33% 62% At Floor No Floor Not At Floor Floor Status – Variable Rate Loans 49% 25% 5% 21% Daily Within 3Mo 4 to 12 Mo Over 12 Mo Variable Rate Loans – Rate Reset Date Net interest income sensitivity given gradual, parallel shift in interest rates across the yield curve with a static balance sheet Q2 Highlights • Acquisition of Spirit did not significantly change rate profile • 55% of loans are variable rate vs 56% in Q1 • 45% of loans are fixed rate vs 44% in Q1 • Significant reduction in variable rate loans at floor • 5% of variable rate loans at floor at end of Q2 vs 30% at the end of Q1 • 49% of variable rate loans reprice immediately • 74% of variable rate loans reprice in less than 3 months Assumptions in Estimates

18 Strong Regulatory Capital Position: significantly above “well capitalized” guidelines (1) As of December 31, for each respective year shown above; Q2 22 data as of June 30, 2022 9.8% 10.2% 10.9% 13.4% 13.8% 12.1% 2017 2018 2019 2020 2021 Q2 22 W ELL C APITALIZED 8.0% 9.8% 10.2% 10.9% 13.4% 13.8% 12.1% 2017 2018 2019 2020 2021 Q2 22 11.4% 13.4% 13.7% 16.8% 16.8% 14.8% 2017 2018 2019 2020 2021 Q2 22 9.2% 8.8% 9.6% 9.1% 9.1% 9.2% 2017 2018 2019 2020 2021 Q2 22 W ELL C APITALIZED 5.0% Tier 1 Leverage Ratio (1) CET1 Capital Ratio (1) W ELL C APITALIZED 6.5% Tier 1 Risk - Based Capital Ratio (1) Total Risk - Based Capital Ratio (1) W ELL C APITALIZED 10.0% Proven track record of prudently maintaining strong regulatory capital levels, while also returning excess capital to shareholders through dividends and share buybacks

$10.1 $93.3 $0.0 $0.0 $20.0 $3.1 $0.0 $51.4 $77.9 $16.1 $50.0 Q4 19 Q1 20 Q2 20 Q3 20 Q4 20 Q1 21 Q2 21 Q3 21 Q4 21 Q1 22 Q2 22 Suspended Plan Precluded due to acquisitions Creating long - term shareholder value while returning excess capital to shareholders (1) Based on July 12, 2022, closing stock price of $20.84 and annualized 2022 cash dividend rate ($0.19*4) (2) Market conditions and our capital needs will drive the decisions regarding additional, future stock repurchases (3) As of December 31, for each respective year shown above and at the end of the quarter for each respective quarter shown abo ve (4) Non - GAAP measure that management believes aids in the discussion of results. See Appendix for Non - GAAP reconciliation * Represents the estimated annualized cash dividend rate based on the current quarterly cash dividend rate on the Company’s Cla ss A common stock ($0.19*4). The future payments of dividends is not guaranteed and is subject to various factors, including app rov al by the Board of Directors $0.20 $0.22 $0.24 $0.27 $0.29 $0.31 $0.34 $0.37 $0.38 $0.38 $0.38 $0.38 $0.40 $0.42 $0.44 $0.46 $0.48 $0.50 $0.60 $0.64 $0.68 $0.72 $0.76 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022* 113 consecutive years 30 - 35% targeted payout ratio 3.6% dividend yield (1) Proven Dividend Record Share Repurchase Program (2) • 2.0 million shares repurchased in the quarter under 2022 program authorized by the Board in Jan - 22 • $24.57 weighted average price Q2 Highlights $22.65 $24.33 $26.30 $27.53 $28.82 $26.32 $25.31 2017 2018 2019 2020 2021 Q1 22 Q2 22 Book Value Per Common Share (3) +12% $12.34 $14.18 $15.89 $16.56 $17.71 $15.22 $14.07 2017 2018 2019 2020 2021 Q1 22 Q2 22 Tangible Book Value Per Common Share (3) (4) +14% 19 Decrease in book value and tangible book value per common share during 2022 attributable to change in unrealized gains (losses) on AFS securities portfolio resulting from drastic fluctuation in interest rates . We believe this is to be a temporary condition as losses should accrete to capital through time and as securities mature

Credit Quality

21 Credit Quality: Key credit quality metrics show improvement and reflect… Source: S&P Global Market Intelligence 2017 – 2021 (1) As of December 31, for each respective year shown above; Q2 22 data as of June 30, 2022 (2) ALLL for 2017 – 2019 and ACL 2020 - 2022 (3) Net charge - offs to average loans (annualized) for the respective quarter Nonperforming loans / loans (1) Nonperforming assets / total assets (1) 0.81% 0.67% 0.65% 0.96% 0.57% 0.42% 2017 2018 2019 2020 2021 Q2 22 0.83% 0.64% 0.55% 0.64% 0.31% 0.26% 2017 2018 2019 2020 2021 Q2 22 Quarterly Trend 6/30/22 3/31/22 Change NPL / Loans 0.42% 0.53% (11) bps Nonperforming Loans (in millions) $63.6 $64.3 $(0.7) NPA / Assets 0.26% 0.29% (3) bps Nonperforming Assets (in millions) $70.0 $70.9 $(0.2) Past Due 30+ Days / Loans 0.11% 0.19% (8) bps Net Charge - offs / Average Loans (3) 0.02% 0.22% (20) bps NPL Coverage Ratio 334% 278% 56 bps ACL / Loans 1.41% 1.49% (8) bps … our conservative risk profile and strategic decision in 2019 to de - risk acquired loan portfolios ACL/ALLL (2) / Loans (%) and ACL/ALLL ($) (1) $ in millions $42 $57 $68 $220 $238 $205 $213 0.39% 0.48% 0.46% 1.52% 1.85% 1.71% 1.41% 0.00% 0.20% 0.40% 0.60% 0.80% 1.00% 1.20% 1.40% 1.60% 1.80% 2.00% $0 $25 $50 $75 $100 $125 $150 $175 $200 $225 $250 2017 2018 2019 1/1/20 CECL Adoption 2020 2021 Q2 22 Q2 Highlights • NPL ratio drops 11 bps linked quarter • NPAs to total assets ends the quarter at 26 bps • NPL coverage ratio remains strong at 334 % • Net charge - offs total 2 bps of average loans • Improved credit quality metrics reflect economic conditions in the markets we serve and geographic diversification of our loan portfolio • ACL to loans at healthy 1 . 41 %

22 Allowance for Credit Losses (ACL): reflects geographic diversification and risk profile ACL – Allowance for Credit Losses on Loans (1) Non - GAAP measure that management believes aids in the discussion of results. See Appendix for Non - GAAP reconciliation $ in millions ACL ACL / Loans ACL/ Loans excluding PPP (1) ACL as of 3/31/21 $ 235.1 1.93% 2.06% Q2 21 Recapture of Provision (10.0) Q2 21 Net recoveries 2.1 ACL as of 6/30/21 $ 227.2 2.00% 2.08% Q3 21 Recapture of Provision (19.9) Q3 21 Net Charge - Offs (4.8) ACL as of 9/30/21 $ 202.5 1.87% 1.91% Q4 21 Recapture of Provision (24.0) Day 2 CECL Provision (Landmark/Triumph) 22.7 Q4 21 Net Charge - Offs (9.3) Day 1 PCD Allowance (Landmark/Triumph) 13.4 ACL as of 12/31/21 $ 205.3 1.71% 1.73% Q1 22 Recapture of Provision (19.9) Q1 22 Net Charge - Offs (6.5) ACL as of 3/31/22 $ 178.9 1.49% 1.50% Q2 22 Provision - Day 2 CECL Provision (Spirit) 30.3 Q2 22 Net Charge - Offs (0.7) Day 1 PCD Allowance (Spirit) 4.1 ACL as of 6/30/22 $ 212.6 1.41% 1.41% Allowance for Credit Losses on Loans and Loan Coverage Reserve for Unfunded Commitments $ in millions As of 3/31/21 As of 6/30/21 As of 9/30/21 As of 12/31/21 As of 3/31/22 As of 6/30/22 Unfunded Commitments $2,039 $2,130 $2,254 $2,943 $3,428 $4,473 Reserve $22.4 $22.4 $22.4 $22.4 $22.4 $25.9 Reserve / Unfunded Balance 1.1% 1.1% 1.0% 0.8% 0.7% 0.6% ACL METHODOLOGY AS OF 6/30/22: ▪ Qualitative allocation: 0.49% ▪ Quantitative allocation: 0.91% ▪ Moody’s June 2022 scenarios with management’s weighting: Baseline (52%) / S2 (34%) / S3 (14%) ▪ Total ACL / Loans: 1.41%

Key Takeaways

24 Key Takeaways 1 Significant revenue growth in the quarter driven by solid legacy SFNC net interest income growth, net interest margin expansion and the acquisition of Spirit 2 Positive operating leverage fueled by revenue growth and well contained operating expense growth . Spirit provides additional opportunities to enhance revenue generation 3 Strategic repositioning of loan portfolio over the past two years provided further diversification of risk profile while also establishing capacity for future loan and revenue growth 4 Solid liquidity and strong capital positions provide foundation for future growth and reflect our disciplined approach to navigating various economic cycles

Appendix

26 Impact of Spirit includes Day 2 accounting provision and merger related costs 1) Non - GAAP measures that management believes aids in the discussion of results. See appendix for Non - GAAP reconciliation Evolution: Tangible Book Value per Share (1) and Tangible Common Equity Ratio (1) Tangible Book Value Per Share Evolution Q1 22 Impact of Spirit Share Buyback Δ in Accumulated Other Comprehensive Income Q2 22 Other Dividend Earnings Tangible Common Equity Ratio Evolution Q1 22 Impact of Spirit Share Buyback Δ in Accumulated Other Comprehensive Income Q2 22 Other Dividend Earnings

27 Breakout: Loan portfolio by Category as of March 31, 2022 as of June 30, 2022 $ in millions Balance $ % of Total Loans Balance $ % of Total Loans Classified $ Nonperforming $ ACL % Unfunded Commitment $ Unfunded Commitment Reserve Total Loan Portfolio Consumer - Credit Card 184 2% 190 1% 1 1 3.5% - Consumer - Other 181 1% 205 1% - - 1.4% 29 Real Estate - Construction 1,423 12% 2,083 14% 6 3 1.2% 2,447 Real Estate - Commercial 5,763 48% 7,082 47% 190 20 1.8% 505 Real Estate - Single - family 2,043 17% 2,358 16% 34 22 0.6% 323 Commercial 1,955 16% 2,593 17% 32 17 1.2% 1,060 Payroll Protection Plan (PPP) 62 1% 19 - - - - - Mortgage Warehouse 166 1% 168 1% - - 0.2% - Agriculture 150 1% 219 1% 1 - 0.3% 106 Other 102 1% 194 1% - - 1.8% 3 Total Loan Portfolio 12,029 100% 15,110 100% 263 64 1.41% 4,473 0.6% Loan Concentration : C&D 54% 71% CRE 205% 237% Select Loan Categories (excluding PPP) Retail 1,186 10% 1,473 10% 18 3 2.3% 180 Nursing / Extended Care 334 3% 341 2% 15 - 1.2% 12 Healthcare 396 3% 471 3% 15 - 1.2% 126 Multifamily 632 5% 831 6% 9 - 0.7% 874 Hotel 829 7% 882 6% 112 14 3.4% 33 Restaurant 398 3% 470 3% 4 1 1.9% 28 NOO Office 750 6% 921 6% 1 - 3.4% 69 Energy 48 - 55 - 3 3 5.5% 41

28 Non - GAAP Reconciliations Q2 Q3 Q4 Q1 Q2 $ in thousands, except per share data 2021 2021 2021 2022 2022 Calculation of Adjusted Earnings Net Income $ 74,924 $ 80,574 $ 48,238 $ 65,095 $ 27,454 Certain items Gain on sale of branches (16) - - - - Merger related costs 686 1,401 13,591 1,886 19,133 Branch right sizing 39 (3,041) 1,648 909 380 Day 2 CECL provision - - 22,688 - 33,779 Tax effect⁽¹⁾ (185) 429 _ (9,912) _ (731) _ (13,928) Certain items, net of tax __ __524 (1,211) ____ 28,015 2,064 39,364 Adjusted earnings (non - GAAP) $ _75,448 $ _79,363 $ _76,253 $ 67,159 $ 66,818 Calculation of Earnings and Adjusted Earnings per Diluted Share Net Income $ 74,924 $ 80,574 $ 48,238 $ 65,095 $ 27,454 Less: Preferred stock dividend 13 13 8 _ - _ - Earnings available to common shareholders $ _74,911 $ _80,561 $ _48,230 $ 65,095 $ 27,454 Diluted earnings per share $ 0.69 $ 0.74 $ 0.42 $ 0.58 $ 0.21 Adjusted earnings (non - GAAP) $ 75,448 $ 79,363 $ 76,253 $ 67,159 $ 66,718 Less: Preferred stock dividend 13 13 8 - - Adjusted earnings available to common shareholders (non - GAAP) $ _75,435 $ _79,350 $ _76,245 $ 67,159 $ 66,718 Adjusted diluted earnings per share $ 0.69 $ 0.73 $ 0.67 $ 0.59 $ 0.52 (1) Effective tax rate of 26.135%

29 Non - GAAP Reconciliations $ in thousands, except per share data and share count 2017 2018 2019 2020 Calculation of Book Value and Tangible Book Value per Share Total common stockholders' equity $ 2,084,564 $ 2,246,434 $ 2,988,157 $ 2,975,889 Intangible assets: Goodwill (842,651) (845,687) (1,055,520) (1,075,305) Other intangible assets (106,071) (91,334) (127,340) (111,110) Total intangible assets (948,722) (937,021) (1,182,860) (1,186,415) Tangible common stockholders' equity (non - GAAP) $ 1,135,842 $ 1,309,413 $ 1,805,297 $ 1,789,474 Shares of common stock outstanding 92,029,118 92,347,643 113,628,601 108,077,662 Book value per common share $ 22.65 $ 24.33 $ 26.30 $ 27.53 Tangible book value per common share (non - GAAP) $ 12.34 $ 14.18 $ 15.89 $ 16.56 Q2 Q3 Q4 Q1 Q2 $ in thousands, except per share data and share count 2021 2021 2021 2022 2022 Calculation of Book Value and Tangible Book Value per Share Total common stockholders' equity $ 3,038,599 $ 3,029,764 $ 3,248,841 $ 2,961,607 $ 3,259,895 Intangible assets: Goodwill (1,075,305) (1,075,305) (1,146,007) (1,147,007) (1,310,528) Other intangible assets (103,759) (100,428) (106,235) (102,748) (137,285) Total intangible assets (1,179,064) (1,175,733) (1,252,242) (1,249,755) (1,447,813) Tangible common stockholders' equity (non - GAAP) $ 1,859,535 $ 1,854,031 $ 1,996,599 $ 1,711,852 $ 1,812,082 Shares of common stock outstanding 108,386,669 106,603,231 112,715,444 112,505,555 128,787,764 Book value per common share $ 28.03 $ 28.42 $ 28.82 $ 26.32 $ 25.31 Tangible book value per common share (non - GAAP) $ 17.16 $ 17.39 $ 17.71 $ 15.22 $ 14.07

30 Non - GAAP Reconciliations Q2 Q3 Q4 Q1 Q2 $ in thousands 2021 2021 2021 2022 2022 Calculation of Adjusted Noninterest Income Noninterest Income (GAAP) $ 47,115 $ 48,550 $ 46,601 $ 42,218 $ 40,178 Less: Gain (loss) on sales of securities 5,127 5,248 (348) (54) (150) Less: Certain Items (non - GAAP) _ 445 (239) 2 ____ - ____(88) Adjusted Noninterest Income (non - GAAP) $ 41,543 $ 43,541 $ 46,947 $ 42,272 $ 40,416 Calculation of Adjusted Noninterest Expense Noninterest Expense (GAAP) $ 114,657 $ 114,333 $ 141,597 $ 128,417 $ 156,813 Less: Certain Items (non - GAAP) _1,154 (1,879) 15,241 _2,795 _(19,425) Adjusted Noninterest Expense (non - GAAP) $ 113,503 $ 116,212 $ 126,356 $ 125,622 $ 137,388 Calculation of Noninterest Expense to Average Assets Average total assets $ 23,257,921 $ 23,255,541 $ 24,698,022 $ 24,826,199 $ 26,769,032 Noninterest expense to average total assets 1.97% 1.97% 2.29% 2.07% 2.34% Adjusted noninterest expense to average assets (non - GAAP) 1.95% 2.00% 2.05% 2.02% 2.05% Calculation of Total Revenue per Employee (FTE) Net Interest Income (GAAP) $ 146,533 $ 145,237 $ 153,081 $ 145,606 $ 185,099 Noninterest Income (GAAP) 47,115 48,550 46,601 42,218 40,178 Total Revenue $ 193,648 $ 193,787 $ 199,682 $ 187,824 $ 225,277 Total Revenue $ 193,648 $ 193,787 $ 199,682 $ 187,824 $ 225,277 Less: gain (loss) on sales of securities 5,127 5,248 (348) (54) (150) Less: Certain Items (non - GAAP) 445 (239) 2 - (88) Adjusted Total Revenue $ 188,076 $ 188,778 $ 200,028 $ 187,878 $ 225,515 Employees (FTE) 2,783 2,740 2,877 2,893 3,233 Total Revenue per Employee (FTE) $ 69.58 $ 70.73 $ 69.41 $ 64.92 $ 69.68 Adjusted Total Revenue per Employee (FTE) $ 67.58 $ 68.90 $ 69.53 $ 64.94 $ 69.75 FTE – Full time equivalent

31 Non - GAAP Reconciliations FTE – full time equivalent Q2 Q3 Q4 Q1 Q2 $ in thousands 2021 2021 2021 2022 2022 Calculation of Noninterest Income to Total Revenue Total Noninterest Income $ 47,115 $ 48,550 $ 46,601 $ 42,218 $ 40,178 Less: Gain (loss) on sales of securities 5,127 5,248 (348) (54) (150) Less: Certain Items (non - GAAP) 445 (239) 2 - (88) Adjusted Noninterest Income (non - GAAP) $ 41,543 $ 43,541 $ 46,947 $ 42,272 $ 40,416 Noninterest Income to Total Revenue 24.33% 25.05% 23.34% 22.48% 17.83% Adjusted Noninterest Income to Adjusted Total Revenue 22.09% 23.06% 23.47% 22.50% 17.92% Noninterest Income per Employee $ 16.93 $ 17.72 $ 16.20 $ 14.59 $ 12.43 Adjusted Noninterest Income per Employee (FTE) $ 14.93 $ 15.89 $ 16.32 $ 14.61 $ 12.50 Q2 Q3 Q4 Q1 Q2 $ in thousands 2021 2021 2021 2022 2022 Calculation of Efficiency Ratio Noninterest expense $ 114,657 $ 114,333 $ 141,597 $ 128,417 $ 156,813 Certain items (non - GAAP) (1,154) 1,879 (15,241) (2,795) (19,425) Other real estate and foreclosure expense (863) (339) (576) (343) (142) Amortization of intangible assets (3,333) _ (3,331) ___ __(3,486) ____ __(3,486) ___ __(4,096) Efficiency ratio numerator $ 109,307 $ 112,542 $ 122,294 $ 121,793 $ 133,150 Net interest income $ 146,533 $ 145,237 $ 153,081 $ 145,606 $ 185,099 Noninterest income 47,115 48,550 46,601 42,218 40,178 Certain items (non - GAAP) (445) 239 (2) - 88 (Gain) loss on sale of securities (5,127) (5,248) 348 54 150 Fully taxable equivalent adjustment 4,548 _ 4,941 ___ _ _5,579 ____ __ 5,602 ___ _ _6,096 Efficiency ratio denominator $ 192,624 $ 193,719 $ 205,607 $ 193,480 $ 231,611 Efficiency Ratio 56.75% 58.10% 59.48% 62.95% 57.49%

32 Non - GAAP Reconciliations Q2 Q3 Q4 Q1 Q2 $ in thousands 2021 2021 2021 2022 2022 Calculation of Pre - Provision Net Revenue (PPNR) Net interest income $ 146,533 $ 145,237 $ 153,081 $ 145,606 $ 185,099 Noninterest income 47,115 48,550 46,601 42,218 40,178 Less: Gain (loss) on sale of securities 5,127 5,248 (348) (54) (150) Less: Noninterest Expense 114,657 114,333 141,597 128,417 156,813 Pre - Provision Net Revenue $ 73,864 $ 74,206 $ 58,433 $ 59,461 $ 68,614 Calculation of Adjusted Pre - Provision Net Revenue Net interest income $ 146,533 $ 145,237 $ 153,081 $ 145,606 $ 185,099 Noninterest income 47,115 48,550 46,601 42,218 40,178 Less: Gain (loss)on sale of securities 5,127 5,248 (348) (54) (150) Less: Noninterest Expense 114,657 114,333 141,597 128,417 156,813 Plus : Gain on sale of branches (16) - - - - Plus: Merger related costs 686 1,401 13,591 1,886 19,133 Plus: Branch right sizing costs 39 (3,041) 1,648 909 380 Adjusted Pre - Provision Net Revenue $ 74,589 $ 72,566 $ 73,672 $ 62,256 $ 88,127

33 Non - GAAP Reconciliations Q1 Q2 $ in thousands 2022 2022 Calculation of Tangible Common Equity Ratio Total common stockholders’ equity $ 2,961,607 $ 3,259,895 Less: Intangible assets 1,249,755 1,447,813 Tangible common stockholders’ equity (non - GAAP) $ 1,711,852 $ 1,812,082 Total assets $ 24,482,268 $ 27,218,609 Less: Intangible assets 1,249,755 1,447,813 Tangible total assets (non - GAAP) $ 23,232,513 $ 25,770,796 Common equity to total assets 12.10% 11.98% Tangible common equity ratio (non - GAAP) 7.37% 7.03% Calculation of total loans and deposit, excluding acquisition of Spirit Total loans $ 12,028,593 $ 15,110,344 Less: Spirit loans, net of fair value adjustments - 2,258,918 Total loans, excluding Spirit (non - GAAP) $ 12,028,593 $ 12,851,426 Total deposits $ 19,392,422 $ 22,035,863 Less: Spirit deposits, net of fair value adjustments - 2,719,016 Total deposits, excluding Spirit (non - GAAP) $ 19,392,422 $ 19,316,847 Change in total loans Q2 vs Q1 26% Change in total loans Q2 vs Q1, excluding Spirit 7% Change in total deposits 14% Change in total deposits Q2 vs Q1, excluding Spirit - %

Arkansas	0-6253	71-0407808
(State or other jurisdiction of incorporation)	(Commission File Number)	(I.R.S. Employer Identification No.)

501 Main Street, Pine Bluff, Arkansas		71601
(Address of principal executive offices)		(Zip Code)

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common stock, par value $0.01 per share	SFNC	The NASDAQ Global Select Market

Exhibit 99.1	Press Release dated July 21, 2022
Exhibit 99.2	Investor Presentation issued on July 21, 2022
Exhibit 104	Cover Page Interactive Data File (embedded within the Inline XBRL Document)

	SIMMONS FIRST NATIONAL CORPORATION

	/s/ James M. Brogdon
Date: July 21, 2022	James M. Brogdon, Executive Vice President,
	Chief Financial Officer and Treasurer