Company announcement
No. 39 / 2026
2
• Petrelintide, amylin analog. Reached a key milestone
with the announcement of decision to advance
petrelintide monotherapy into Phase 3 registrational
trials , planned for initiation later in 2026 .
• Survodutide, glucagon/GLP -1 receptor dual agonist.
Boehrin ger Ingelheim presented results from the
SYNCHRONIZE
TM
-1 Phase 3 trial in people living with
overweight or obesity. The trial met its primary
endpoints and showed up to 16.6% weight loss with
survodutide. The proportion of lean mass loss reflect ed
no more than 1 1.3% of change in total tissue mass at the
highest dose . The lean loss ratio reported in this
company announcement has been updated from 10.8%
to 11.3% following a recalculation of the dataset .
• Survodutide, glucagon/GLP -1 receptor dual agonist.
Boeh ringer Ingelheim presented positive results from the
SYNCHRONIZE
TM
-MASLD Phase 3 trial in people with
overweight or obesity and MASLD with evidence of
inflammation and/or fibrosis. The trial met its primary
endpoints and show ed that 6 out of 10 survodutide -
treated participants achiev ing liver fat normalization .
• Survodutide, glucagon/GLP -1 receptor dual agonist.
Boehringer Ingelheim announced expansion of the
development program for survodutide with four Phase
3(b) trials initiating in 2026 to address key u nmet needs
in people living with obesity and real -world care.
• ZP6590, GIP receptor agonist. Zealand Pharma ini tiated
a first -in-human clinical trial with ZP6590.
Chronic inflammation
• ZP9830, Kv1.3 Ion Channel Blocker. Zealand Pharma
initiated a Phase 1b trial with efficacy endpoints ,
investigat ing ZP9830 in people with psoriasis. The tria l
was initiated on the back of positive topline results from
the single ascending dose (SAD) part of the combined
SAD/multiple ascending dose (MAD) Phase 1a clinical
trial with ZP9830 announced earlier in the year .
Corporate
• Camilla Sylvest and Iris Löw -Friedrich were elected to
the Zealand Pharma Board of Directors , both bringing
deep expertise in metabolic health . Two strategically
vital additions as the company enters the next phase of
scaling into a generational biotech.
• On May 7, 2026, Zealand Pharma launched a share buy -
back program of up to USD 200 million / DKK 1.3 billion .
For more information on the share buy -back program,
refer to Zealand Pharma Company Announc ement No.
13/2026 , May 7, 2026. As of August 7, 2026, total
accumulated transactions under the program amount to
DKK 742 million.
• Zealand Pharma entered into a USD 100 million royalty
purchase and sale agreement with Royalty Pharma for
rusfertide. For mor e information, refer to Zealand
Pharma Company Announcement No. 38/2026 , August
12, 2026 .
• Continued to attract top talent and experienced leaders ,
with several senior hires bringing vital experience in
metabolic he alth. This momentum was underscored by
Medwatch’s 2026 Image Report, in which Zealand
Pharma took the number one spot as the most attractive
employer in the Danish Life Science sector.
Upcoming events in the second half of 2026
Obesity
• Petrelintide, amylin analog. In H2 2026, Zealand Pharma
and Roche expect to initiate registrational Phase 3 trials
with petrelintide monotherapy.
• Petrelintide, amylin analog. In H2 2026, Zealand Pharma
expects to report topline results from the Phase 2
ZUPREME -2 trial in people with overweight or obesity
and typ e 2 diabetes.
• Petrelintide/enicepatide (CT -388), amylin+GLP -1/GIP
fixed -dose combination. Zealand Pharma and Roche
expect to initiate the Phase 2 ZYNERGY trial in people
with overweight or obesity in H2 2026 .
• Survodutide, glucagon/GLP -1 receptor dual agonist.
Results from the Phase 3 SYNCHRONIZE
TM
-2 trial will be
presented at the 62nd Annual Meeting of the European
Association for the Study of Diabetes (EASD) . R esults
from the SYNCHRONIZE
TM
-CVOT trial are expected to be
reported and presented later in the year .
Rare diseases
• Glepaglutide in SBS . Zealand Pharma expects to
complete the EU marketing authorization application
review in H2 2026. In parallel , the company is engaging
in partnership discussions for future commercialization
of glepaglutide for short bowel syndrome (SBS).