
HOFSETH BIOCARE | ANNUAL REPORT
10
Content
Corporate governance
The board of director’s report 2024
Financial statements
Statement of comprehensive income
Statement of financial position
Statement of cash flows
Statement of changes in equity
Notes to the accounts
Declaration of the Board of Directors and
CEO in Hofseth BioCare ASA
Auditors report
of its laboratory in Midsund to ISO 17025
standards, enabling in-house microbiological
analyses. This certification improves quality
control and reduces reliance on third-party
laboratories, enhancing operational efficiency.
Third quarter
The third quarter of 2024 marked another period
of sustained revenue growth for the company.
However, this revenue growth came at the
expense of a temporary gross margin reduction,
driven by one-off production issues that have
since been fully resolved. New management
with focus on operational efficiency and
accountability, led to improved capacity
utilization and production quality.
In the business-to-business (B2B) human
nutrition segment, revenue surged by 91%
compared to the previous year. This growth was
primarily driven by strong demand in Europe
for CalGo
®
and increased ProGo
®
sales in Asia.
The company strengthened its distributor
network and conducted key customer meetings
across Asia, including Japan, Indonesia,
Thailand, and Taiwan. Participation in the Food
Ingredients Asia event in Indonesia provided
additional market exposure and new business
opportunities.
Consumer and pet health sales continued to
expand, with Brilliant Petcare securing a key
agreement for Brilliant Salmon Oil to enter the
Fressnapf marketplace, Europe’s largest pet
retailer. Core product sales remained strong,
with the 100ml trial-size Brilliant Salmon Oil
performing well in Italy and the Calcium Collagen
Powder showing positive sales momentum in the
UK. As a result, retailers such as Pets at Home
UK expanded their offerings, further boosting
category performance.
The company continued to make progress in
R&D, publishing a groundbreaking White Paper
on OmeGo
®
titled “Viral Recovery and Enhanced
Immune Health with Natural, Full-Spectrum
Omega Salmon Oil”. Another significant research
milestone was the publication of a study in
the journal Marine Drugs, demonstrating that
ProGo
®
’s clinically significant 6-7% weight loss
effect over six to eight weeks is attributed to
GLP-1 modulation. These findings provide a
strong foundation for further exploration into
THE BOARD OF DIRECTORS’ REPORT FINANCIAL STATEMENTS AUDITORS REPORT
CORPORATE GOVERNANCEANNUAL REPORT 2024
identifying the specific peptide responsible for
this effect, with planned studies in 2025.
Advancements were also made in drug
discovery, when HBC Immunology completed
preclinical xenograft studies on FT-002a, a
peptide derived from ProGo
®
intended as a
co-therapy for prostate cancer. The novel
oral formulation, FT-002a-O, demonstrated
significant enhancement of the anti-tumor
effects of enzalutamide, the market-leading
androgen receptor inhibitor. Further studies will
continue, with an Investigational New Drug (IND)
application on track for the second half of 2025.
In clinical trials, the company completed a
120-subject study on the effects of OmeGo
®
in urban environments with high pollution
exposure. This study, designed based on the
successful COVID-19 pilot trial, evaluated
cough and sleep improvement as primary and
secondary endpoints. Preliminary results are
encouraging. Research also progressed on
SPHi peptides for gastrointestinal health, with
Stanford University preparing for a proof-of-
concept clinical trial in inflammatory bowel
disease, pending regulatory approval.
The company continued expanding its raw
material sourcing capabilities, increasing
annualized capacity utilization to 78% in the
third quarter. To support future scalability, the
cold storage expansion project was started,
addressing a critical bottleneck in capacity
utilization.
Fourth quarter
HBC continued to build on a year of strong
performance, ending the quarter with renewed
momentum across all segments. This strong
performance was driven primarily by the high‐
margin human nutrition business, where a shift
toward premium products has resulted in over
100% year‐on‐year growth in the quarter. Notably,
the B2B segment recorded strong sales of
CalGo
®
and OmeGo
®
, with B2B gross margins
improving.
The pet and feed segment also delivered
record‐high long‐term contracts, underpinning
the company’s competitive position even in a
challenging commodity pricing environment.
Consumer health returned to growth in Q4,
with revenue in this segment increasing by
33% compared to the same quarter in 2023.
Enhanced retail distribution channels, including
renewed traction in both brick-and-mortar and
e-commerce, further contributed to this rebound.
A strategic expansion in the U.S. market was a
key focus during the quarter with new strategic
retail partnerships and signed a significant U.S.
brand launch for OmeGo
®
scheduled for the end
of Q1 2025, thereby laying the groundwork for
sustained future growth.
The fourth quarter saw continued strides in
scientific research and clinical validation,
bolstering the company’s reputation for
innovation. In the realm of human nutrition, a
key R&D highlight was the publication in the
peer-reviewed journal “Marine Drugs”. The paper
detailed the GLP-1 and GIP agonist activities
of ProGo
®
, elucidating the mechanism behind
its weight loss effect in overweight adults. This
publication not only reinforces the product’s
efficacy but also sets the stage for further dose-
optimization studies aimed at achieving similar
benefits at lower doses.
OmeGo
®
research has also advanced
significantly. A dedicated clinical study
investigating its immune-supporting properties
in urban-dwelling subjects, exposed to
particulate matter pollution, demonstrated
promising improvements in respiratory
function, sleep quality, and reduced coughing
symptoms. These encouraging top-line results
will be submitted for publication early in 2025,
further substantiating the health benefits of our
unrefined salmon oil.
The bone health portfolio continued to yield
encouraging findings. Interim analysis from the
ongoing CalGo
®
study has indicated its potential
in preventing further bone thinning in osteopenic
women, with early signs of increased bone
mass. Full results are anticipated in the end of
2025 and are expected to underscore CalGo
®
’s
role in the prevention of osteoporosis.
Additional preclinical work on osteoarthritis
has shown that the novel NT-II™ formulation
may offer superior joint healing effects
when compared to traditional alternatives.
Meanwhile, research into the oncology pipeline
has progressed with animal model studies
on the peptide candidate FT-002a. Early data
demonstrate significant anti-tumor activity
in models of aggressive prostate cancer, and
further studies are underway, with more detailed
results expected early in 2025.
In parallel, studies on MA-022s, an analogue
derived from OmeGo
®
, have provided promising
data in animal models of eosinophilic (allergic)
asthma, showing reductions in key pathological
markers such as goblet cell hyperplasia and
smooth muscle hypertrophy. HBC will prepare a
clinical trial of its SPHi peptides for inflammatory
bowel disease in H1 2025, a project that will be
spearheaded by Stanford’s School of Medicine
pending IND approval. These R&D efforts
collectively reinforce the company’s leadership in
leveraging marine-based bioactives for advanced
nutritional and therapeutic applications.
Operational efficiency was a central theme in
the fourth quarter, and the company executed
a significant restructuring program to create a
leaner and more scalable organization moving
into 2025.
Product mix improvements and higher pricing in
key segments drove a notable increase in gross
margins and operational metrics also improved
markedly with capacity utilization reaching 89%
in the quarter, a reflection of both enhanced
production efficiency and optimized supply chain
management.