D. E. Shaw & Co., Inc.

Position in ARWR — Arrowhead Pharmaceuticals, Inc.

CIK 1009207 New York, NY

Back to ARWR Full portfolio

Position in ARWR

as of Jun 30, 2026 · filed Aug 14, 2026 Compact

Position Value

$35,176,454

-$39,050,188 QoQ

Shares Held

431,560

-63.5% QoQ

Ownership

0.306%

of shares outstanding

% of Portfolio

0.02%

of 13F equity value

Holder Rank

#48

of 497 holders

Holding Since

Mar 2020

19 quarters on record

Voting authority Sole 99% Shared 0% None 1%

Common Shares in ARWR Over Time

Shares Held

Position Value (USD)

Derivatives in ARWR

reported options exposure · as of Mar 31, 2026

CallValue

$564,300

CallShares

9,000

PutValue

PutShares

Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.

Position in Biotechnology

Healthcare · as of Jun 30, 2026

D. E. Shaw & Co., Inc. holds $5,017,559,982 across 217 Biotechnology names. ARWR ranks #34 (0.7% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	INSM	INSMED Inc	5,877,959	$626,707,987
2	ALNY	Alnylam Pharmaceuticals, Inc.	1,104,109	$332,369,932
3	EXEL	Exelixis, Inc.	5,551,747	$302,070,554
4	BBIO	BridgeBio Pharma, Inc.	3,633,007	$270,586,360
5	TGTX	Tg Therapeutics, Inc.	3,400,808	$186,840,390
6	HALO	Halozyme Therapeutics, Inc.	2,006,479	$157,047,110
7	AXSM	Axsome Therapeutics, Inc.	604,753	$148,025,391
8	PTCT	Ptc Therapeutics, Inc.	1,548,919	$126,345,322

All Filings in ARWR

Export CSV

34 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-06-30	$35,176,454	431,560	-63.5%	Shares	Defined	2026-08-14
2026-03-31	$564,300	9,000	-50.0%	Call	Defined	2026-05-15
2026-03-31	$74,226,642	1,183,838	+710.5%	Shares	Defined	2026-05-15
2025-12-31	$9,697,188	146,064	+619.5%	Shares	Defined	2026-02-17
2025-12-31	$1,195,020	18,000	-61.9%	Call	Defined	2026-02-17
2025-09-30	$700,181	20,301	-55.4%	Shares	Defined	2025-11-14
2025-06-30	$924,300	58,500	+170.8%	Put	Defined	2025-08-14
2025-06-30	$747,340	47,300	+181.5%	Call	Defined	2025-08-14
2025-03-31	$275,184	21,600	+94.6%	Put	Defined	2025-05-15
2024-09-30	$215,007	11,100	+11.0%	Put	Defined	2024-11-14
2023-12-31	$1,391,504	45,474	+44.9%	Shares	Defined	2024-02-14
2023-06-30	$1,119,367	31,390	+2.7%	Shares	Defined	2023-08-14
2023-03-31	$776,300	30,563	+273.2%	Shares	Defined	2023-05-15
2022-06-30	$288,334	8,189	-75.3%	Shares	Defined	2022-08-15
2021-12-31	$2,195,657	33,117	-21.0%	Shares	Defined	2022-02-14
2021-12-31	$663,000	10,000	0.0%	Put	Defined	2022-02-14
2021-09-30	$2,616,190	41,906	-30.6%	Shares	Defined	2021-11-15
2021-09-30	$624,300	10,000	0.0%	Put	Defined	2021-11-15
2021-06-30	$828,200	10,000	0.0%	Put	Defined	2021-08-16
2021-06-30	$5,003,321	60,412	+36.7%	Shares	Defined	2021-08-16
2021-03-31	$2,929,907	44,185	-50.1%	Shares	Defined	2021-05-17
2021-03-31	$663,100	10,000	0.0%	Put	Defined	2021-05-17
2020-12-31	$1,289,064	16,800	0.0%	Call	Defined	2021-02-16
2020-12-31	$6,798,201	88,599	-66.3%	Shares	Defined	2021-02-16
2020-12-31	$767,300	10,000	0.0%	Put	Defined	2021-02-16
2020-09-30	$430,600	10,000	-71.3%	Put	Defined	2020-11-16
2020-09-30	$11,323,573	262,972	-39.3%	Shares	Defined	2020-11-16
2020-09-30	$723,408	16,800	0.0%	Call	Defined	2020-11-16
2020-06-30	$1,507,331	34,900	+74.5%	Put	Defined	2020-08-14
2020-06-30	$725,592	16,800	0.0%	Call	Defined	2020-08-14
2020-06-30	$18,723,642	433,518	-35.9%	Shares	Defined	2020-08-14
2020-03-31	$483,336	16,800	—	Call	Defined	2020-05-15
2020-03-31	$575,400	20,000	—	Put	Defined	2020-05-15
2020-03-31	$19,452,001	676,121	—	Shares	Defined	2020-05-15
No filing history on record for this holder in this stock.