8-K
BridgeBio Pharma, Inc. (BBIO)
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): January 12, 2026
BridgeBio Pharma, Inc.
(Exact name of Registrant as Specified in Its Charter)
| Delaware | 001-38959 | 84-1850815 |
|---|---|---|
| (State or Other Jurisdiction of Incorporation) | (Commission File Number) | (IRS Employer Identification No.) |
| 3160 Porter Dr., Suite 250 | ||
| --- | --- | |
| Palo Alto, CA | 94304 | |
| (Address of Principal Executive Offices) | (Zip Code) |
Registrant’s Telephone Number, Including Area Code: (650) 391-9740
Not Applicable
(Former Name or Former Address, if Changed Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
| ☐ | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
|---|---|
| ☐ | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
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| ☐ | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
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| ☐ | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
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Securities registered pursuant to Section 12(b) of the Act:
| Title of each class | Trading<br><br> <br>Symbol(s) | Name of each exchange on which registered |
|---|---|---|
| Common Stock, par value $0.001 per share | BBIO | The Nasdaq Global Select Market |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
| Item 2.02 | Results of Operations and Financial Condition. |
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On January 12, 2026, BridgeBio Pharma, Inc., or the Company, issued a press release that contains certain preliminary financial information as of and for the quarter and fiscal year ended December 31, 2025. Specifically, the press release states that the Company estimates it had approximately $587.5 million of cash, cash equivalents and marketable securities as of December 31, 2025 and $146.0 million and $362.4 million in net product revenue for the quarter ended December 31, 2025, and the fiscal year ended December 31, 2025, respectively.
The information in this Item 2.02 is unaudited and preliminary, and does not present all information necessary for an understanding of the Company’s results of operations for the quarter and fiscal year ended December 31, 2025, or financial condition as of December 31, 2025. The audit of the Company’s consolidated financial statements for the quarter and fiscal year ended December 31, 2025 is ongoing and could result in changes to the information in this Item 2.02.
| Item 7.01 | Regulation FD Disclosure. |
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The disclosure in Item 2.02 above is hereby incorporated by reference into this Item 7.01, and a copy of the press release referenced in Item 2.02 is furnished as Exhibit 99.1 hereto.
The information contained in Items 2.02 and 7.01, as well as Exhibit 99.1, to this Current Report on Form 8-K shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall such information be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.
| Item 8.01 | Other Events. |
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On January 12, 2026, the Company also presented a business update at the 44^th^ Annual J.P. Morgan Healthcare Conference. A copy of the Company’s presentation slides, which has been published on the Company’s website, is filed as Exhibit 99.2 to this current report on Form 8-K and is incorporated by reference herein.
Forward Looking Statements
This Current Report on Form 8-K contains forward-looking statements. Statements in this Current Report on Form 8-K or the materials furnished or filed herewith may include statements that are not historical facts and are considered forward-looking within the meaning of Section 27A of the Securities Act of 1933, as amended (the Securities Act), and Section 21E of the Securities Exchange Act of 1934, as amended (the Exchange Act), which are usually identified by the use of words such as “anticipates,” “believes,” “continues,” “estimates,” “expects,” “hopes,” “intends,” “may,” “plans,” “projects,” “remains,” “seeks,” “should,” “will,” and variations of such words or similar expressions. The Company intends these forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act and Section 21E of the Exchange Act. These forward-looking statements, including express and implied statements relating to the Company’s preliminary and unaudited estimate of cash resources as of December 31, 2025 and the Company’s preliminary and unaudited estimate of net product revenue for the quarter and full year ended December 31, 2025; the commercial success of Attruby; the clinical timeline and clinical and therapeutic potential for the new antibody depleter program for ATTR-CM; the timing and expectations regarding the status and progress of the Company’s various clinical trials, including data readouts for these trials; the safety, efficacy and mechanisms and the clinical, therapeutic and market potential of the Company’s clinical development programs and pipeline, including BBP-418, infigratinib, encaleret and BBP-812; expected timing for submitting New Drug Applications with the U.S. Food and Drug Administration (“FDA”) and similar submissions with foreign regulatory authorities, receiving U.S. approval and commencing commercial launch for BBP-418 and encaleret; the Company’s anticipated interactions with and feedback from the FDA and similar foreign regulatory authorities; the efficiency of the Company’s engine to rapidly and efficiently deliver medicines; the Company’s value creation potential for patients; the timing and progress of advancing GondolaBio’s pipeline, including the clinical potential of GondolaBio’s PORT-77 in EPP; the Company’s financial position, including the Company’s expectations regarding potential market opportunities, reaching certain clinical and regulatory milestones, and the Company’s anticipated funding to support the potential launch of three additional medicines globally; the potency and safety of the Company’s product candidates, the potential benefits of the Company’s product candidates; and the potential for greater patient access to medications, among others, reflect the Company’s current views about the Company’s plans, intentions, expectations and strategies, which are based on the information currently available to the Company and on assumptions the Company has made. Although the Company believes that its plans, intentions, expectations and strategies as reflected in or suggested by those forward-looking statements are reasonable, the Company can give no assurance that the plans, intentions, expectations or strategies will be attained or achieved. Furthermore, actual results may differ materially from those described in the forward-looking statements and will be affected by a number of risks, uncertainties and assumptions, including factors beyond the Company’s control, that could cause actual results, performance or achievement to differ materially and adversely from those anticipated or implied in the statements. Such factors may include, but are not limited to, initial and ongoing data from the Company’s preclinical studies and clinical trials not being indicative of final data, the design and success of ongoing and planned clinical trials, future regulatory filings, approvals and/or sales, despite having ongoing and future interactions with the FDA or other regulatory agencies to discuss potential paths to registration for the Company’s product candidates, the FDA or such other regulatory agencies not agreeing with the Company’s regulatory approval strategies, components of the Company’s filings, such as clinical trial designs, conduct and methodologies, or the sufficiency of data submitted, the continuing success of the Company’s collaborations, the Company’s ability to obtain additional funding, potential volatility in the Company’s share price, the impacts of current macroeconomic and geopolitical events, including changing conditions from hostilities in Ukraine and in Israel and the Gaza Strip, increasing rates of inflation and changing interest rates, on business operations and expectations. Further information regarding the risks, uncertainties and other factors that may cause differences between the Company’s expectations and actual results is contained in the Risk Factors section of the Company’s most recent Annual Report on Form 10-K, subsequent Quarterly Reports on Form 10-Q and the Company’s other filings with the U.S. Securities and Exchange Commission. Moreover, the Company operates in a very competitive and rapidly changing environment in which new risks emerge from time to time. These forward-looking statements are based upon the current expectations and beliefs of the Company’s management as of the date of this Current Report on Form 8-K, and are subject to certain risks and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. Except as required by applicable law, the Company assumes no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise.
| Item 9.01 | Financial Statements and Exhibits. |
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| (d) | Exhibits. |
| --- | --- |
| Exhibit | Description |
| --- | --- |
| 99.1 | Press Release dated January 12, 2026. |
| 99.2 | Slides from BridgeBio Pharma, Inc.’s J.P. Morgan Healthcare Conference Presentation, dated January 12, 2026. |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
| BridgeBio Pharma, Inc. | |||
|---|---|---|---|
| Date: | January 12, 2026 | By: | /s/ Thomas Trimarchi |
| Thomas Trimarchi, Ph.D. | |||
| President and Chief Financial Officer |
Exhibit 99.1
BridgeBio Announces Commercial Progress, Program Updates, and 2026 Milestones at the 44^th^ Annual J.P. Morgan Healthcare Conference
Preliminary unaudited Q4 and Full Year 2025 net Attruby® product revenue of $146.0 million and $362.4 million, respectively
Attruby (acoramidis) is rapidly becoming the first-choice therapy for newly diagnosed ATTR-CM patients with 6,629 unique patient prescriptions written by 1,632 prescribers as of December 31, 2025, driven by differentiated clinical data and growing real-world confidence
New TTR amlyoid depleter antibody program announced to explore the potential of ATTR-CM disease reversal; program expected to advance into the clinic between 2027 – 2028
- The interim analysis from FORTIFY, BridgeBio’s Phase 3 study of LGMD2I/R9, demonstrated broad benefit in all subgroups across α-controlled endpoints and a highly clinically meaningful and statistically significant 2.6 point benefit on NSAD relative to placebo at 12 months; based on these data, the FDA recommended orienting NDA toward traditional full approval; the Company intends to submit an NDA in first half of 2026
Rapid increase in diagnosis of ADH1 with >1,700 unique patients identified since October 2023; BridgeBio intends to submit an NDA to the FDA based on results from CALIBRATE, the Company’s Phase 3 clinical trial of encaleret, in the first half of 2026
Initiation of RECLAIM-HP, phase 3 trial of encaleret in chronic hypoparathyroidism, in summer 2026 subsequent to a recently completed End of Phase 2 interaction with FDA
LPLV achieved for PROPEL 3, the registrational Phase 3 study of infigratinib for children with achondroplasia, with topline results expected by end of Q1 2026; LPI achieved for the Phase 2 portion of ACCEL 2/3, the registrational study of infigratinib for children with hypochondroplasia
Approximately $587.5 million in cash, cash equivalents, and marketable securities as of December 31, 2025; well financed to sustain the continued acceleration of Attruby and potentially launch three additional medicines globally
PALO ALTO, Calif., January 12, 2026 (GLOBE NEWSWIRE) — BridgeBio Pharma, Inc. (Nasdaq: BBIO) (“BridgeBio” or the “Company”), a new type of biopharmaceutical company focused on genetic diseases, today provided updates on its commercial progress for Attruby (acoramidis), status of late-stage pipeline programs, and anticipated 2026 milestones. These updates were presented by co-founder and CEO, Neil Kumar, Ph.D., at the 44^th^ Annual J.P. Morgan Healthcare Conference in San Francisco, CA on Monday, January 12 at 7:30 am PT.
“BridgeBio was built on the belief that if you start with patients, move with urgency, and stay disciplined on science and data, you can deliver transformative medicines with unprecedented results quickly, safely, and effectively,” said Dr. Kumar. “Over the past decade, we’ve built a company that proves this model. Today, we’re seeing progress widely across that decentralized model, allowing us to drive impact for several different communities and hopefully doubling the number of patients that we’re able to serve by the end of 2026.”
Webcast Information
To access the webcast of BridgeBio’s presentation, please visit the “Events & Presentations” page within the Investors section of the BridgeBio website at http://investor.bridgebio.com. A replay of the webcast will be available on the BridgeBio website for 30 days following the event.
About Attruby® (acoramidis)
INDICATION
Attruby is a transthyretin stabilizer indicated for the treatment of the cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis \(ATTR-CM\) in adults to reduce cardiovascular death and
cardiovascular-related hospitalization.
IMPORTANT SAFETY INFORMATION
Adverse Reactions
Diarrhea \(11.6% vs 7.6%\) and upper abdominal pain \(5.5% vs 1.4%\) were reported in patients treated with Attruby versus placebo, respectively. The majority of these adverse reactions were mild and resolved
without drug discontinuation. Discontinuation rates due to adverse events were similar between patients treated with Attruby versus placebo \(9.3% and 8.5%, respectively\).
About BridgeBio Pharma, Inc.
BridgeBio Pharma, Inc. \(BridgeBio; Nasdaq: BBIO\) is a new type of biopharmaceutical company founded to discover, create, test, and deliver transformative
medicines to treat patients who suffer from genetic diseases. BridgeBio’s pipeline of development programs ranges from early science to advanced clinical trials. BridgeBio was founded in 2015 and its team of experienced drug discoverers,
developers and innovators are committed to applying advances in genetic medicine to help patients as quickly as possible. For more information visit bridgebio.com and follow us on LinkedIn, X, Facebook, Instagram, and YouTube.
BridgeBio Pharma, Inc. Forward-Looking Statements
This press release contains forward-looking statements. Statements in this press release may include statements that are not historical facts and are considered forward-looking within the meaning of Section 27A
of the Securities Act of 1933, as amended \(the Securities Act\), and Section 21E of the Securities Exchange Act of 1934, as amended \(the Exchange Act\), which are usually identified by the use of words such as “anticipates,” “believes,”
“continues,” “estimates,” “expects,” “hopes,” “intends,” “may,” “plans,” “projects,” “remains,” “seeks,” “should,” “will,” and variations of such words or similar expressions. BridgeBio intends these forward-looking statements to be covered by
the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act and Section 21E of the Exchange Act. These forward-looking statements, including express and implied statements relating to the Company’s
preliminary and unaudited estimate of cash resources as of December 31, 2025 and the Company’s preliminary and unaudited estimate of net product revenue for the quarter and full year ended December 31, 2025; the commercial success of Attruby; the
clinical timeline for the new antibody depleter program for ATTR-CM; the timing and expectations regarding the status and progress of the Company’s various clinical trials, including data readouts for these trials; expected timing for submitting
New Drug Applications with the FDA for BBP-418 and encaleret; the Company’s anticipated interactions with and feedback from the FDA; and the Company’s financial position, including the Company’s anticipated funding to support the potential launch
of three additional medicines globally, among others, reflect the Company’s current views about the Company’s plans, intentions, expectations and strategies, which are based on the information currently available to the Company and on assumptions
the Company has made. Although the Company believes that its plans, intentions, expectations and strategies as reflected in or suggested by those forward-looking statements are reasonable, the Company can give no assurance that the plans,
intentions, expectations or strategies will be attained or achieved. Furthermore, actual results may differ materially from those described in the forward-looking statements and will be affected by a number of risks, uncertainties and
assumptions, including factors beyond the Company’s control, that could cause actual results, performance or achievement to differ materially and adversely from those anticipated or implied in the statements. Such factors may include, but are not
limited to, initial and ongoing data from the Company’s preclinical studies and clinical trials not being indicative of final data, the design and success of ongoing and planned clinical trials, future regulatory filings, approvals and/or sales,
despite having ongoing and future interactions with the FDA or other regulatory agencies to discuss potential paths to registration for the Company’s product candidates, the FDA or such other regulatory agencies not agreeing with the Company’s
regulatory approval strategies, components of the Company’s filings, such as clinical trial designs, conduct and methodologies, or the sufficiency of data submitted, the continuing success of the Company’s collaborations, the Company’s ability to
obtain additional funding, potential volatility in the Company’s share price, the impacts of current macroeconomic and geopolitical events, including changing conditions from hostilities in Ukraine and in Israel and the Gaza Strip, increasing
rates of inflation and changing interest rates, on business operations and expectations. Further information regarding the risks, uncertainties and other factors that may cause differences between the Company’s expectations and actual results is
contained in the Risk Factors section of the Company’s most recent Annual Report on Form 10-K, subsequent Quarterly Reports on Form 10-Q and the Company’s other filings with the U.S. Securities and Exchange Commission. Moreover, the Company
operates in a very competitive and rapidly changing environment in which new risks emerge from time to time. These forward-looking statements are based upon the current expectations and beliefs of the Company’s management as of the date of this
press release, and are subject to certain risks and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. Except as required by applicable law, BridgeBio assumes no obligation
to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise.
BridgeBio Media Contact:
Bubba Murarka, Executive Vice President
contact@bridgebio.com
\(650\)-789-8220
BridgeBio Investor Contact:
Chinmay Shukla, Senior Vice President, Strategic Finance
ir@bridgebio.com
Exhibit 99.2
J.P. Morgan Presentation January 12, 2026
Forward Looking Statements and Disclaimer The presentation contains forward-looking statements. Statements made or presented may include statements that are not historical facts and are considered forward-looking within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Words such as “believe,” “anticipate,” “plan,” “expect,” “intend,” “will,” “may,” “goal,” “potential,” “should,” “could,” “aim,” “estimate,” “predict,” “continue” and similar expressions or the negative of these terms or other comparable terminology are intended to identify forward-looking statements, though not all forward-looking statements necessarily contain these identifying words. We intend these forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act and Section 21E of the Exchange Act. These forward-looking statements, including express and implied statements relating to the preliminary and unaudited estimate of cash resources as of December 31, 2025 and the preliminary and unaudited estimate of net product revenue for Attruby for the quarter ended December 31, 2025; the commercial success of Attruby; the clinical timeline and clinical and therapeutic potential for the new antibody depleter program for ATTR-CM; the timing and expectations regarding the status and progress of our various clinical trials, including data readouts for these trials; the safety, efficacy and mechanisms and the clinical, therapeutic and market potential of our clinical development programs and our pipeline, including infigratinib, BBP-418, encaleret and BBP-812; expected timing for submitting New Drug Applications with the U.S. Food and Drug Administration (“FDA”) and similar submissions with foreign regulatory authorities, receiving U.S. approval and commencing commercial launch for BBP-418 and encaleret; our anticipated interactions with and feedback from the FDA and similar foreign regulatory authorities; the efficiency of our engine to rapidly and efficiently deliver medicines; our value creation potential for patients; the timing and progress of advancing GondolaBio’s pipeline, including the clinical potential of GondolaBio’s PORT-77 in EPP; our financial position, including our expectations regarding potential market opportunities, and reaching certain clinical and regulatory milestones; the potency and safety of our product candidates, the potential benefits of our product candidates; and the potential for greater patient access to medications, reflect our current views about our plans, intentions, expectations and strategies, which are based on the information currently available to us and on assumptions we have made. Such statements reflect the current views of the Company with respect to future events and are subject to known and unknown risks, including business, regulatory, economic and competitive risks, uncertainties, contingencies and assumptions about the Company, including, without limitation, risks inherent in developing and commercializing therapeutic products, and those risks and uncertainties described under the heading “Risk Factors” in the Company’s most recent Annual Report on Form 10-K filed with the U.S. Securities and Exchange Commission (“SEC”) and in subsequent filings made by the Company with the SEC, which are available on the SEC’s website at www.sec.gov. In light of these risks and uncertainties, many of which are beyond the Company’s control, the events or circumstances referred to in the forward-looking statements, express or implied, may not occur. The actual results may vary from the anticipated results and the variations may be material. You are cautioned not to place undue reliance on these forward-looking statements, which speak to the Company’s current beliefs and expectations only as of the date of the presentation. Except as required by law, the Company disclaims any intention or responsibility for updating or revising any forward-looking statements made or presented at the presentation in the event of new information, future developments or otherwise. This presentation discusses product candidates that are investigational only and have not yet been approved for marketing by the FDA or any comparable foreign regulatory authority. No representation is made as to the safety or effectiveness of the product candidates for the therapeutic use for which such product candidates are being studied. Certain information communicated at the presentation may relate to or is based on studies, publications, surveys and other data obtained from third-party sources and the Company’s own internal estimates and research. While the Company believes these third-party sources to be reliable as of the date of the presentation, it has not independently verified, and makes no representation as to the adequacy, fairness, accuracy or completeness of, any information obtained from third-party sources. In addition, certain information to be communicated at the presentation involves a number of assumptions and limitations, and there can be no guarantee as to the accuracy or reliability of such assumptions. Finally, such research has not been verified by any independent source. Such information is provided as of the date of the presentation and is subject to change without notice. The Company has not verified, and will not verify, any part of this presentation, and the Company makes no representation or warranty, express or implied, as to the accuracy or completeness of the information to be communicated at the presentation or as to the existence, substance or materiality of any information omitted from the presentation at the presentation. The Company disclaims any and all liability for any loss or damage (whether foreseeable or not) suffered or incurred by any person or entity as a result of anything contained or omitted from this document or the related presentation and such liability is expressly disclaimed. This Presentation is for informational purposes only. This Presentation shall not constitute an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of any securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. 2
Thank you to our investors for enabling us to deliver hope and medicines to the patients that we serve 3 Fortify results reflect interim analysis data. BridgeBio does not commercialize Nulibry but receives royalties. Truseltiq was withdrawn from the market voluntarily after receiving FDA approval. Obtained Approval for 3 Medicines + 2 Ongoing Pivotal Trials > 8,500 patients impacted by our therapies > 70 papers published > 35 academic partnerships 19 INDs created < $40M spend to proof-of-concept data 15 active trials in ecosystem 2 Positive Phase 3 Results
Today we will review commercial/late-stage programs and early-stage progress 4 Attruby revenue Late-stage data and regulatory progress Early-stage research and our potentially best-in-class EPP program
Continued Attruby commercial momentum 1Represents preliminary, unaudited results for the fourth quarter ended December 31, 2025, based on management’s current expectations and subject to completion of year end audit procedures. See Forward Looking Statements and Disclaimer on slide 2 regarding risks and uncertainties that could cause actual results to differ. $146M1 Q4 2025 Net Product Revenue NEW INFORMATION 5
Continued Attruby commercial momentum and patient impact 6 6,629 Unique U.S. patient prescriptions for Attruby 1,632 Unique U.S. prescribing HCPs >25% Estimated share of NBRx for Attruby As of December 31st, 2025 NEW INFORMATION
We continue to study the impact of Attruby across clinical dimensions …approved product with a label specifying near-complete stabilization of TTR First and ONLY… Reduction in cumulative cardiovascular outcomes within the first month of treatment in patients with ATTR-CM 1 month Reduction in composite of all-cause mortality and recurrent cardiovascular-related hospitalization events at Month 30 42% Reduction in the cumulative frequency of cardiovascular-related hospitalization events at Month 30 50% 7
Attruby significantly reduced the risk of CVM or recurrent CVH through Month 30 vs. placebo by 49% with separation of curves starting by Month 1 Estimated Mean Cumulative Events of CVM or Recurrent CVH Through Month 30 (mITT Population, Acoramidis, n = 409; Placebo, n = 202) Acoramidis (n = 409) Placebo (n = 202) Participants with CVM or recurrent CVH, n (%) 136 (33.3) 98 (48.5) Hazard ratio (95% CI)a 0.51 (0.43, 0.62) p value < 0.0001 Source: Masri et al. (2025) Early, Long-Term Reduction in CV-Outcomes With Acoramidis, JACC; HFSA 2025 Presentation (Masri) Acoramidis Reduces Cumulative Cardiovascular Outcomes Within the First Month of Treatment in Transthyretin Amyloid Cardiomyopathy: Results From ATTRibute-CM Data are for the mITT population in the ATTRibute-CM study, defined as all the participants who had undergone randomization, received at least one dose of acoramidis or placebo, and had at least one efficacy evaluation after baseline; participants with eGFR < 30 mL/min/1.73 m2 were excluded aModified Andersen-Gill model with a robust variance estimator, with treatment, age, NYHA class, genotype, eGFR, and log-transformed baseline NT-proBNP as covariates CI, confidence interval; CVH, cardiovascular-related hospitalization; CVM, cardiovascular mortality; eGFR, estimated glomerular filtration rate; mITT, modified intention-to-treat; NT-proBNP; N-terminal pro-B-type natriuretic peptide; NYHA, New York Heart Association 8
Attruby’s advantages stem from the fact that it is the most potent stabilizer 9 Nelson et al., Amyloid 2020; 28(1), 24–29. Miller, M. et al. J Med Chem. 2018;61:7862-7876. Pinheiro, F. et al. Proc Natl Acad Sci U.S.A. 2026; 123(1) e2519908122. AG10 is the former internal development code for Attruby/Beyonttra (acoramidis). Sees more target (superior free fraction) Binds more target (superior kd2) Glues the target together stronger (enthalpic binding mode) “Our thermodynamic analysis further supports the notion that binding enthalpy (ΔH), not affinity (Kd or ΔG), better predicts the conformational stabilization imparted by kinetic stabilizers…. These results underscore the need to prioritize enthalpy-driven interactions during stabilizer design.” Acoramidis is the only stabilizer with “near complete” stabilization in the label The multiplicity of advantages to superior stabilization continue to be better understood and elucidated in novel research “Given the variability in stoichiometry in the experiments between tafamidis and AG10 and TTR, the data always tell the same story, that AG10 is better than tafamidis as would be expected from the determined binding constants.” – Prof. Jeffery Kelly (inventor of tafamidis) in email correspondence with Dr. Isabella Graef, February 12, 2013. Bold added.
Liver TTR Tetramer Misfolded amyloidogenic monomer TTR Fibril Restrictive cardiomyopathy via TTR fibril deposition Along with work on Attruby, BridgeBio has initiated a depleter program to explore the potential of ATTR-CM disease reversal 10 Source: Wanniarachchige et al., 2025 Attr uby Near-complete stabilizer that prevents dissociation of TTR tetramers into monomers Depl eter Monoclonal antibody that clears existing amyloid deposits via macrophage-mediated phagocytosis Dr. Richard Scheller Former Professor, Stanford Former CSO, Genentech Former EVP and Executive Committee, Roche Genentech Chairman of R&D, BridgeBio ATTR-CM Disease Pathophysiology Led by Renowned Antibody Expert NEW PROGRAM Existing TTR therapies target upstream …but unmet need remains for patients with existing tetramer stabilization and synthesis… amyloid deposits for downstream clearance
11 BridgeBio’s depleter is engineered across 4 novel properties for potential differentiation on clinical efficacy and dosing convenience 1 2 3 4 Depleter Mechanism of Action BridgeBio’s Differentiated Target Properties Improved fibril:tetramer binding ratio >10× preferential binding to misfolded TTR fibrils vs. native TTR tetramers Binds more target Faster macrophage recruitment First depleter to activate Fcγ receptors to boost macrophage activity Clears more target pH sensitivity Intentionally designed for pH-dependent antigen release inside macrophages Extends antibody half-life Half-life extension First depleter engineered for enhanced FcRn binding Extends antibody half-life NEW PROGRAM Program expected to advance into the clinic in 2027–2028
12 Limitations of first-generation depleters highlight the opportunity for a next-generation depleter to better serve patient needs Competitors BridgeBio Property Company A Company B BridgeBio’s Depleter Why it Matters Improved fibril:tetramer binding ratio Limited >10× preferential binding to misfolded TTR fibrils vs. native TTR tetramers Maximizes on-target engagement with misfolded TTR fibrils Minimizes unintended clearance of physiologic TTR tetramers Faster macrophage recruitment First depleter to activate Fcγ receptors to boost macrophage activity Accelerates amyloid clearance Potentially enables earlier time to separation on clinical endpoints pH sensitivity Limited Intentionally designed for pH- dependent antigen release inside macrophages Enables antibody recycling after phagocytosis Half-life extension First depleter engineered for enhanced FcRn binding Extends circulating half-life Enables more convenient dosing vs. monthly IV infusions 1 2 3 4 NEW PROGRAM Note: Green = favorable; orange = unfavorable; grey = in-between.
2K 7K 9K LGMD2I/R91,2 (US + EU) (Phase 3 fully enrolled and positive interim analysis topline announced as of Oct. 2025) Fukuyama congenital muscular dystrophy (Japan) BBP-418 Status: Positive Phase 3 Interim Result in LGMD2I/R9 Addressable people by indication (current population with addressable mutations) 1 Liu, et al. Genetics in Medicine. 2019; 2 Includes all patients with potentially treatable mutations in FKRP, FKTN, and ISPD; 3 Eichstadt et al Clin Cosmet Investig Dermatol; 4 Cure Duchenne and Sarepta; 5 MDA and Friedreich’s Ataxia Research Alliance; 6 Evaluate; 7 M&A value of Reata Product Indication Dystrophic Epidermolysis Bullosa DMD w/ amenable exon 51 mutations Friedreich’s Ataxia Prevalence (US) ~4K3 ~1.3-2K4 ~4-5K5 Projected peak year sales (US)6 / Market cap $640M / $7.6B $541M / $2.5B $565M / $7.3B7 Analogous markets to LGMD2I/R9
Unprecedented, clinically meaningful improvement across all pre-specified endpoints and well-tolerated safety profile at interim analysis MET PRIMARY AND ALL KEY SECONDARY ENDPOINTS VS. PLACEBO 14 1.8x increase in glycosylated αDG at 3 months 82% decrease in CK at 12 months Faster ambulation compared to deterioration on placebo Improved pulmonary function compared to deterioration on placebo (p<0.0001) An appreciable share of patients achieved normal levels on some measures in just 1 year Well tolerated safety profile (p<0.0001) (p<0.0001) (p=0.0071) Low discontinuation rate; higher in PBO arm αDG = alpha dystroglycan; PBO = placebo; CK = creatine kinase Source: Data on file
-20 -15 10 15 20 L276I homozygous Other FKRP genotype 12 to <18 years 18 to 60 years FVC (baseline): ≥80% FVC (baseline): 40-80% -1.00 -0.75 -0.50 -0.25 0.00 0.25 0.50 0.75 1.00 L276I homozygous Other FKRP genotype 12 to <18 years 18 to 60 years FVC (baseline): ≥80% FVC (baseline): 40-80% Planned subgroup analyses show consistent benefit of BBP-418 vs. placebo in all subgroups across α-controlled efficacy endpoints at 12 months 15 Biomarker Forced vital capacity (% predicted) LS Mean Difference (95% CI) 100-meter timed test (m/s) LS Mean Difference (95% CI) Functional Note: 1 Pre-specified inferential statistics not performed for subgroups representing <15% of all participants in relevant analysis set; αDG=alpha dystroglycan; PBO=placebo; FKRP= Fukutin Related Protein; FVC=forced vital capacity. Source: Data on file Glycosylated αDG (% of control) LS Mean Difference (95% CI) L276I homozygous Other FKRP genotype 12 to <18 years Not calculated1 18 to 60 years FVC (baseline): ≥80% FVC (baseline): 40-80% -50 -40 -30 -20 -10 0 10 20 30 40 50 Favor placebo Favor BBP-418 Serum creatine kinase (U/L) LS Mean Difference (95% CI) L276I homozygous Other FKRP genotype 12 to <18 years Not calculated1 18 to 60 years FVC (baseline): ≥80% FVC (baseline): 40-80% 4,000 3,000 2,000 1,000 0 -1,000 -2,000 -3,000 -4,000 Favor placebo Favor BBP-418 -10 -5 0 5 Favor placebo Favor BBP-418 Favor placebo Favor BBP-418 NEW INFORMATION
BBP-418 treated patients experienced highly clinically meaningful 2.6 point benefit on NSAD relative to placebo even at early 12-month timepoint 16 -1.3 1.3 -1.5 -1.0 -0.5 0.0 0.5 1.0 1.5 Placebo (n=22) BBP-418 (n=46) p=0.0001* Change from baseline in NSAD (points) Source: Data on file. Improved gross motor function Even a 1-point difference in NSAD can mean… Requiring someone’s help to get up Able to get up from a fall Requiring assistance or mobility aids Able to use stairs or steps Able to toilet independently Asking for help to get up from toilet NSAD (primary endpoint at 36 months) benefit is highly clinically meaningful even at 12 months * Nominally statistically significant based on exploratory analysis; analysis not part of alpha-controlled hierarchy at interim analysis NSAD = North Star Assessment for Limb-Girdle Type Muscular Dystrophies; Least-Squares Mean Change from Baseline at 12-month timepoint NEW INFORMATION
We completed a successful meeting with the FDA and they 17 We anticipate filing an NDA with the FDA in 1H 2026 recommended orienting our NDA toward traditional and full approval All data from the Phase 3 FORTIFY study were presented to the agency, including key sensitivities FDA acknowledged the data “…demonstrate consistent treatment effects on multiple efficacy endpoints” FDA recommends orienting NDA toward traditional approval NEW INFORMATION
Encaleret Status: Positive Phase 3 Result in ADH1 Addressable people by indication in US (current population with ADH1) An analogous market to ADH1 is XLH (X-linked Hypophosphatemia) XLH ADH1 Prevalence (US) 12K4 12K Disease burden Hypophosphatemia Acute - hypocalcemia Chronic - hypercalciuria Standard of care Vitamin D, daily phosphate5 Vitamin D, daily calcium Registrational endpoint Serum phosphate Serum and urine calcium Projected peak year sales $2B+6 $1B+ 1Dershem, J. et al. Amer. J. Hum. Genetics, 2020. 2 Chang, J.B. et al. Amer. J. Hum. Genetics, 2025. 3Roszko, K.L. et al. JBMR, 2022. 4Dahir, K. et al. J. Endocr. Soc., 2020. 5Munns, C.F. et al., JBMR Plus., 2023. 6Evaluate Pharma. 12K Individuals with ADH1 ~12K ADH1 prevalent population in the US based on 4 population databases1-2 9K Symptomatic 73% of patients with ADH1 are symptomatic3 3K – 5K Currently Addressable 40-60% of symptomatic ADH1 patients are estimated to be diagnosed today; anticipate increase
CALIBRATE achieved & exceeded all criteria set forth as an upside target, with a 76% responder rate following 24 weeks of encaleret treatment Upside Target Clinical Profile Outcome Observed Statistically significant primary analysis result compared to conventional therapy Primary endpoint met (p <0.0001) demonstrating superiority to conventional therapy At Week 24, ≥50% of study participants achieve target serum and urine Ca on encaleret 76% (34 out of 45) achieved target serum and urine Ca on encaleret vs. 4% on conventional therapy Majority of participants randomized to encaleret able to remain independent from conventional therapy1 Among encaleret responders at Week 24, none required conventional therapy during Period 31 At Week 24, mean iPTH within normal range on encaleret >90% of participants administered encaleret achieved iPTH above the lower limit of the reference range Comparable safety and tolerability profile to conventional therapy Encaleret was well-tolerated; no discontinuations related to study drug 19 1Requirement for conventional therapy defined as oral calcium >600 mg/day and/or active vitamin D during Period 3. Ca = Calcium; iPTH = Intact Parathyroid Hormone. Encaleret is an investigational drug. Its safety and efficacy have not been fully evaluated by any regulatory authority.
>90% of CALIBRATE participants administered encaleret demonstrated a pharmacologic response Primary Analysis – Within Group Week 4 SoC (N=45) Week 24 Encaleret (N=45) p-value3 Number of Participants Meeting The Primary Endpoint (Responder status)1,2 2 34 Proportion, % 4% 76% Difference in Proportion of Responders (95% CI) 71% (58%, 84%) <0.0001 Key Secondary Analysis – Within Group Week 4 SoC (N=45) Week 24 Encaleret (N=45) p-value3 Number of Participants With iPTH ≥ LL Reference Range 3 41 Proportion, % 7% 91% Difference in Proportion of Responders (95% CI) 84% (74%, 95%) <0.0001 20 1The primary endpoint assessed responder status of participants who achieved both corrected serum calcium and 24-hour urine calcium in the target range at the completion of the maintenance periods. 2Participants randomized to receive encaleret who required doses of elemental calcium >600 mg/day for >7 days during Period 3 were evaluated as non-responders. 3Analyzed by McNemar’s test. CI = Confidence Interval; iPTH = Intact Parathyroid Hormone; LL = Lower Limit
BridgeBio is pioneering efforts to enable the successful launch of encaleret, potentially the first calcilytic molecule to be approved for any condition Enabled creation of new ICD-10 code dedicated to ADH1 & ADH2 Billable ICD-10 code associated with ADH1 & ADH2 Encaleret has a first-to-market opportunity to potentially establish a new standard of care in ADH1 while benefiting from ecosystem tailwinds supporting patient identification Enabled update to treatment guidelines specifying need for genetic testing1 “We recommend genetic testing and/or family screening in a patient with nonsurgical HypoPT without other obvious aetiology.” Expanded availability of testing through sponsored genetic testing program BridgeBio sponsored genetic testing available for providers & patients at no cost 21 NEW INFORMATION 1Included in updated best practice recommendations for diagnosis and management of hypoparathyroidism (Khan, A. A. et al., Metabolism, 2025.) and European Society of Endocrinology (ESE) treatment guidelines (Bollerslev, J. et al., Eur. J. Endocrinol., 2025.)
Over a 24-month period, >1,700 unique patients were diagnosed with ADH in the US 1Compounded Monthly Growth Rate (CMGR) since the code’s introduction in Oct. 2023. 2Komodo Claims Data, October 2023-September 2025. ICD10 Code E20.810 (Autosomal Dominant Hypocalcemia). 3Based on analysis of Symphony and Definitive Healthcare Claims Data for ICD-10 Code E20.810. Cumulative ADH Patients Diagnosed2 1,000 800 600 400 200 0 10/23 01/24 04/24 07/24 10/24 01/25 04/25 07/25 10/25 ~50% of HCPs diagnosing ADH patients manage ≥5 non-surgical hypoparathyroidism patients3 1,200 1,800 1,600 1,400 17% CMGR NEW INFORMATION 22
Encaleret has the potential to be an orally administered option for patients with chronic hypoparathyroidism (CHP) 1Bollerslev, J. et al., Eur Jour of Endocinol., 2025. 2Khan, A.A. et al., Metabolism, 2025. 3Hartley, I.R. et al., presented at ASBMR 2025 Annual Meeting. ASBMR = American Society for Bone and Mineral Research NEW INFORMATION 23 Encaleret has the potential to normalize blood and urine calcium in CHP patients CHP patients present similarly as ADH1 patients (i.e., hypocalcemia and hypercalciuria) Current guidelines specify normalization of blood and urine calcium as therapeutic goals1,2 In a Phase 2 study (N=10) presented at the ASBMR 2025 meeting, encaleret demonstrated a PTH-independent effect to normalize blood and 24-hour urine calcium in 80% of study participants within 5 days3 Announcing the RECLAIM-HP Phase 3 Study of Encaleret in CHP Initiating in 2026 Completed successful End of Phase 2 interaction with the FDA Phase 3 registrational trial to evaluate encaleret in CHP Primary endpoint will assess achievement of target blood and urine calcium
RECLAIM-HP Phase 3 study of encaleret in chronic hypoparathyroidism to initiate in Summer 2026 1Conventional therapy includes a combination of oral activated vitamin D and/or calcium supplements PBO = Placebo NEW INFORMATION Screening Period 1 Weeks 1-20 Encaleret + Conventional Therapy1 Titration Period PBO + Conventional Therapy1 Titration Period Encaleret + Conventional Therapy1 Maintenance Period PBO + Conventional Therapy1 Maintenance Period Open-Label Extension Period 2 Weeks 20-24 OLE Weeks 24-215 RECLAIM-HP: Global, multi-center, randomized, double-blind, placebo-controlled study Double-blinded treatment period Proportion of participants achieving albumin-corrected blood and urine calcium within target range Primary Endpoint Randomization 2-14 days 24
Infigratinib Status: LPLV in Phase 3 in achondroplasia 1CDC birth estimates; EU Eurostats birth estimates; Foreman, et al. Am J Med Genet. 2020.; Bober, et al. Gene Reviews. 2020.; Wenger, et al. Gene Reviews. 2020.; Al-Namman, et al. J Oral Biol Craniofac Res. 2019. 2Achondroplasia market includes all approved drugs. Represents diagnosed and addressable ACH population with open growth plates 55,000 individuals with achondroplasia in US/EU $5B+ potential global market
Last participant last visit completed; Topline expected Q1 2026 Pivotal Phase 3 Study in children and adolescents (3-<18 years) with achondroplasia and open epiphyses Phase 2 Study In Infants & Toddlers from birth to less than age 3 with achondroplasia Full enrollment completed for Phase 2 portion; data expected 2H 2026 2/3 Phase 2 study followed by a Phase 3 study in children and adolescents with hypochondroplasia First participant enrolled NEW INFORMATION We have achieved LPLV on PROPEL 3 and expect topline in Q1, and we have made significant operational progress on expansion opportunities 26
Designed to target achondroplasia at its genetic source: FGFR3 overactivation Addresses not just overactivation of the MAPK pathway (chondrocyte hypertrophy), but also STAT1 (chondrocyte proliferation) and all other downstream pathways Achieved profound efficacy in animal models, beyond just long bone growth In mouse models of achondroplasia, treatment with infigratinib showed an increase in proximal and distal long bone length (femur +21%, humerus +12%, tibia +33%, ulna 22%, and radius +24%) and foramen magnum area (+17%)5 Demonstrated the largest degree of efficacy (across multiple dimensions1) across any clinical trial for ACH2 Mean change from baseline in AHV: +2.51 cm/yr at M12 Mean absolute AHV: >6 cm/yr at M12 Mean change in height Z-score compared to ACH growth charts: +0.36 SD at M12 Mean improvement in upper-to-lower body segment ratio (proportionality): Decrease of 0.12 (P=0.001) Received the only Breakthrough Designation from the FDA for ACH Met the regulatory requirement of showing preliminary evidence of substantial improvement over SoC Designed to be taken as a daily oral, avoiding side effects associated with CNPs and repeated injections Avoids symptomatic hypotension1, injection site reactions1, and the psychosocial burden of receiving/administering repeated injections3,4 27 Infigratinib: Defining characteristics of a potentially best-in-class program in the ACH landscape 1Savarirayan et al, NEJM, 2024; 2For monotherapy trials in ACH; 3Antal et al, Journal of Pediatric Psychology, 2011; 4Jacobse et al, European Journal of Pediatrics, 2019; 5Komla-Ebri et al, J Clin Invest. 2016.
Infigratinib sprinkle capsules are being developed for oral administration1,2 28 1Savarirayan R, et al. N Engl J Med. 2024;392(9):865–874. 2BridgeBio data on file. *Infigratinib is an investigational agent that is not approved for use by any regulatory authority. Size 2 capsules are shown in photo. Infigratinib is being studied in children over 3 years of age with achondroplasia (0.25 kg/mg/day) as a sprinkle capsule Capsules can be swallowed whole or content (granules) sprinkled on soft food The dosage strength of each capsule depends on how many granules are inside Each child’s dose is based on their weight Capsules (17 mm long*) Granules (2 mm long)
BridgeBio has developed a validated evidence-based perspective to forecasting market share performance 29 Comprehensive market surveys indicated 30-40%+ Attruby share Attruby future competitive market share 25 30 35 40 % market share 45 ATTR-CM experienced prescribers N = 200 Stated share Adjusted share 60 Analog research shows 2nd entrants achieve average ~37% share Average 25th percentile 75th percentile ML-based empirical analysis enables high fidelity drug launch modeling % market share Normalized sales Years from launch Drug launch sales, archetype cluster grouping Median line with 25th – 75th percentile shaded We have analyzed >900 drug launches and built a proprietary algorithm capable of categorizing launch profiles into archetypes and predicting future revenue Note: Stated share adjusted for historical performance of demand study market research on new product launches. Source: BridgeBio market research HCP surveys (n = 184 & n=200), Evaluate Pharma, PhAST Rx, Advisory board, IQVIA LAAD data set
Our market research indicates that infigratinib could capture >50% of treated market share, primarily driven by the favorable oral administration and MOA 30 Attribute TPP for testing market share Indication Children (3 – 18 years) with achondroplasia and open epiphyses MOA Selective FGFR1-3 tyrosine kinase inhibitor Dosing and Administration Once daily capsules (containing minitablets swallowed whole/chewed/sprinkled on soft foods) Primary Endpoint Statistically significant improvement in change from baseline in annualized height velocity (AHV): +1.5 cm/year vs. placebo Safety & Tolerability Well-tolerated AE profile: No injection site reactions or symptomatic hypotension. Less than 10% rate of hyperphosphatemia. Potential share for ACH children % of treated children (N = 95 HCPs; represents ~37% of current market) 52% 28% 20% % of treated children CNP Analog (Daily) CNP Analog (Weekly) Infigratinib 1BridgeBio market research (Analyses from ACH demand forecast Aug – Oct 2025); % of children; patient-weighted responses from n=95 HCPs; Q: Based on the information you just reviewed, please think about how you might decide to prescribe pharmacological therapy to the next 10 children you see who fall into each of the following clinical scenarios. For each scenario, how many of these children would you expect to prescribe each of the following treatment options?
BBP-812 Status: Pivotal trial ongoing in Canavan disease Canavan disease (CD) is an ultra-rare neurodegenerative disease with ~1,000 patients across the US and EU CD is usually fatal within the first two decades of life, and >25% of patients die by the age of 10 years1 Children with CD exhibit global and severe cognitive, motor, and language impairment, missing or regressing on most developmental milestones Children with CD require around the clock care – they cannot hold their heads up, sit, crawl, walk, are generally unable to speak, and suffer from seizures and spasticity There are no therapies available for Canavan disease Canavan disease is a fatal, neurodegenerative and ultra-rare pediatric disease with no approved therapies
Current path to a potential BLA filing in 2027 based on reductions in urine NAA (surrogate endpoint) supported by motor function improvements 32 Urine N-acetylaspartic acid (NAA) levels Hammersmith Infant Neurological Examination (HINE-2) Trajectory BBP-812 dose-dependently reduces urine NAA to levels associated with only mild disease FDA is open to the use of urine NAA as a surrogate endpoint to support accelerated approval of BBP-812 Trajectory analysis shows clear, dose-dependent separation in HINE-2 total score with BBP-812 vs. natural history study Children are also showing improvement on key motor metrics such as sitting, head control, and reaching / grasping Change in HINE-2 Total Score Natural History BBP-812 – Low Dose BBP-812 – High Dose Months since Baseline NEW INFORMATION Source: 10 December 2025 data cut, N = 18
Centralized scale + disease-level focus = ability to have multiple, focused launches 33 Deep program expertise Dedicated affiliate teams stay with programs over time, building deep clinical and community knowledge Tailored launch strategies Each program can pursue the right access, positioning, and sequencing approach Sharper execution Smaller, specialized markets benefit from tailored approaches Benefits of execution at the decentralized program level Benefits of centralized commercial model Build once, scale many Build commercial capabilities once and leverage across launches Cost synergies Leverage fixed costs; Limited incremental additional costs per rare disease launch Compound launch expertise Apply cross-launch insights in both competitive and first-in-class markets to systematically de-risk execution + + + Commercial Platform
Our future: It’s still day 1 in genetic disease 34
We are at day 1 of genetic medicine 35 Maher Nature 2008; Manolio Nature 2009. “..we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP- based heritability.” - Yengo et al, Nature 2022 “We identified 15 traits with no significant difference between WGS-based and pedigree-based heritability estimates, suggesting their heritability is fully accounted for by WGS data.” - Wainschtein et al, Nature 2025 Today, missing heritability is being explained
From the missing heritability to the missing mechanism Variant effect prediction: Alphamissense Pangenome graphs Disease prediction: MILTON 36 Feedback loops in these tools make genetics more actionable for drug development Biological signal can be preserved from variant mechanism intervention High throughput perturbation assays Advances in AI and computational tools Context-, cell type-, and state-dependent multiomics Saturation of genetic variants affecting human traits Larger Biobanks: UKB, AOU, ADG, etc. WGS for non-coding rare variants Long-read sequencing for complex SVs Cell atlases: Human Cell Atlas, Tabula Sapiens Tissue mapping: HuBMAP Large-scale compendia: CellxGENE, TenK10K Perturb-seq to perturb every single gene across the genome MAVE to perturb every possible variant within a gene
Example #1: The GondolaBio pipeline features a diverse set of programs across therapeutic areas and modalities 37 GondolaBio is an independent company from BridgeBio. As of December 31, 2025, BridgeBio has a 27.5% stake in GondolaBio. BridgeBio’s interest in GondolaBio is subject to reduction as additional tranches of capital contributions are funded. NEW INFORMATION Indication Patient Population (US+EU) Discovery Lead Op IND Enabling Phase 1 Phase 2 Erythropoietic Protoporphyria (EPP) 25k Autosomal Dominant Polycystic Kidney Disease (ADPKD) 300k Alpha-1 Antitrypsin Deficiency (AATD) 200k Charcot-Marie-Tooth 1A (CMT1A) 130k Neurofibromatosis Type 1 (NF1) 200k Hereditary Pancreatitis 30k Fibrous Dysplasia 50k Tuberous Sclerosis Complex 1/2 (TSC) 65k Genetic Epilepsy Driven by SynGAP1 Mutations 15k Dup15q Developmental Epileptic Encephalopathy 20k Recurrent Oxalate Kidney Stones 300k Best vitelliform macular dystrophy 15k Early onset preeclampsia 40k +4 discovery programs
Example #2: The Phase 2 Erythropoietic Protoporphyria (EPP) program targets a genetic disease with high unmet need Sunlight causes skin damage and excruciating pain leading to severely impaired lifestyle and quality of life Liver stress and liver damage are also common (20-30%), with a small portion of patients (5%) experiencing liver failure requiring transplant Symptoms present at 4 years on average and are lifelong Standard of care is limited; a tanning agent partially improves symptoms and QoL but does not modify the disease EPP has severe health consequences… …and affects a large patient population 20-25k+ EPP patients in the US and EU 10-14k in US estimated from multiple independent claims datasets Internal genomic prevalence estimates 45-70k genetic incidence in US + EU, with incomplete penetrance and underdiagnosis Pompe DMD Exon PNH Skipping Frederick’s HAE Fabry’s EPP ataxia US & EU pop ~7.5K ~10K ~12K ~13K ~14K ~20-25K+ ~14K Source: Balwani et al. 2017; Balwani et al. 2019; Prevalence estimates on GnomAD, TopMed, Orphanet, DelveInsights, Canaccord (2025), Deutsche Bank (2025), Dinu et al. (2021), Amicus Corporate Presentation (2025), Komodo Claims 38
The pathomechanism of EPP is driven by the heme biosynthesis intermediate protoporphyrin nine (PPIX) in plasma and bile Inhibition of ABCG2 prevents the transport of PPIX out of red blood cells to the plasma Sunlight and liver efficacy Dual mechanism that lowers plasma and bile PPIX may address both the phototoxic and hepatobiliary impacts of EPP Avoid CNS side effects Novel mechanism that does not modulate glycine or other neurotransmitters to prevent headaches, dizziness, or daytime sleepiness Shorten onset of protection Rapid ABCG2 inhibition mechanism to maximize speed of protection after dosing PORT-77 The Portal small molecule PORT-77 is designed as a potentially best-in-class disease modifying therapy to meet three main criteria 39
PORT-77 targets EPP at its source by preventing transport of PPIX out of red blood cells into the plasma, skin, and bile Source: Internal Data 40 PPIX RBCs Plasma, skin, bile ABCG2 PORT-77 has a potential best-in-disease drug profile Mechanism PPIX RBCs PPIX Plasma, skin, bile ABCG2 inhibition keeps PPIX out of the plasma, skin, and bile ABCG2 inhibition PORT-77 is a small molecule ABCG2 inhibitor Orally bioavailable 15nM IC50 for ABCG2 inhibition Highly selective for ABCG2 over other transporters Human half-life (t1/2): 10-21 hrs Favorable ADME properties Composition of matter IP through at least 2044 Which addresses all aspects of EPP safely and rapidly Addresses both skin and liver symptoms Highly safe and well-tolerated in preclinical + phase 1 dosing No CNS side effects Onset of action in minutes vs weeks
PORT-77 is being investigated in the GATEWAY Phase 2a trial Placebo High Dose PORT-77 Period 1 (treatment sequence blinded to participant) Period 2 Follow-up Low Dose PORT-77 placebo Exploratory clinical endpts Endpoints Change in plasma PPIX as Safety and tolerability compared to baseline and PK in EPP patients Single-blind, randomized, placebo-controlled cross-over In-clinic dosing, single-site Design Study population EPP patients Age 18 years or older Days 1-4 Days 5-8 Day 9 41
-90% -80% -70% -60% -50% -40% -30% -20% -10% 0% Baseline PORT-77 has shown the largest PPIX reduction seen to date, reaching steady state within days Low Dose (n=6): ~55% High Dose (n=6): ~75% Dose dependent reductions in Plasma PPIX (relevant disease compartment) observed Largest PPIX reduction seen to date with ~75% at high dose Rapid PPIX reduction to steady state within days PPIX reduction in Literature and past studies Day 1 Day 2 Day 3 Day 4 42 NEW INFORMATION Note: Baseline defined as the pre-dose value on Day 1 of treatment period (D5 of study). Treatment measurements are averages within a day; Source: Internal data
Significant PPIX reduction seen in the Phase 2a, regardless of baseline PPIX value 0 20 40 60 Subject E: -98% 80 100 GATEWAY PPIX reduction at Steady State (n = 12) 120 Baseline Day 4 12h Subject K: -41% Subject B: -55% Subject J: -60% Subject H: -91% Subject A: -19% Subject C: -80% Subject I: -57% Subject D: -77% Subject G: -84% Subject L: -80% Subject F: -59% % PPIX reduction between Baseline and Steady State: Baseline PPIX value (ug/dL) Steady State (D4 12H) Subject A 41 -19% Subject B 104 -55% Subject F 52 -59% Subject G 31 -84% Subject K 108 -41% Subject L 53 -80% Subject C 68 -80% Subject D 22 -77% Subject E 83 -98% Subject H 99 -91% Subject I 67 -57% Subject J 99 -60% Low dose High dose Note: Baseline defined as the pre-dose value on Day 1 of treatment period (D5 of study). D4 12H was the last timepoint of the treatment period (D8 of study); Source: Internal data. Significant responses regardless of baseline value Every subject decreased varying from 20% to 98% Smallest reduction in high dose was 57% NEW INFORMATION 43
safety and tolerability signals identified to date in the Phase 1 and Phase 2a trials PORT-77 has a clean safety profile across dose levels with no SAEs or NEW INFORMATION Predose (n=12) Placebo (n=12) PORT-77 Treatment (n=12) Subjects with any TEAE 3 (25%) 7 (58%) 5 (42%) TEAEs leading to discontinuation 0 0 0 SAEs 0 0 0 Common TEAEs Headache 2 (17%) 3 (33%) 0 Nausea 0 4 (33%) 3 (25%) Loose stools 0 1 (8%) 2 (17%) No SAEs, no discontinuations, and AEs balanced across placebo and treatment period (likely viral) Source: Internal data 44
The EPP program has achieved proof-of-concept for a potential best-in-disease profile Consistent and potential best-in-class PPIX reduction; Dual-mechanism independently treating sunlight and liver symptoms Clean safety profile with no notable AEs in treatment group and lack of CNS effects to date PPIX reduction seen within hours, days to steady-state effect 45
Continued progress across the BridgeBio ecosystem 46 + 4 Other Programs BVMD Preeclampsia Fibrous Dysplasia SYNGAP1 Dup15q Kidney Stones ADPKD AATD CMT1A RAS:PI3Kα Breaker PanKRAS KRASG12C ON / OFF HHypypoochchoonndropElPaPsia Canavan ADH1 Chronic HP Achondroplasia LGMD2I/R9 ATTR-CM Pivotal Discovery Lead Op Pre-IND Proof-of-Concept Commercial As of December 31, 2025, BridgeBio has an 18.2% ownership stake in BridgeBio Oncology Therapeutics and a 27.5% ownership stake in GondolaBio. BridgeBio Oncology Therapeutics and GondolaBio are independent companies from BridgeBio. BridgeBio’s interest in GondolaBio is subject to reduction as additional tranches of capital contributions are funded. EPP NF1 Hereditary Pancreatitis TSC
47 Key takeaways today – significant momentum across the portfolio NEW INFORMATION Attruby: $146M1 in Q4 net product revenue; 6,629 unique patient prescriptions; and >25% NBRx share New antibody depleter program announced for ATTR-CM ATTR-CM LPLV for Phase 3 achondroplasia trial achieved LPI for Phase 2 hypochondroplasia trial achieved Infigratinib Broad benefit of BBP-418 in all subgroups across α-controlled efficacy endpoints at 12 months Highly clinically meaningful and stat sig. 2.6 point benefit on NSAD relative to placebo at 12 months Recommendation from FDA to orient NDA toward traditional approval BBP-418 Additional data demonstrating dose-dependent reductions in urine NAA and motor function improvements Current path to potential BLA filing in 2027 BBP-812 Rapid uptake in diagnosis of ADH1 with >1,700 unique patients identified in claims since October 2023 FDA alignment on and path forward with Phase 3 RECLAIM-HP trial in Chronic HP; expected to initiate in summer 2026 Encaleret Positive Phase 2a data for PORT-77 in EPP GondolaBio 1Represents preliminary, unaudited results for the fourth quarter ended December 31, 2025, based on management’s current expectations and subject to completion of year end audit procedures. See Forward Looking Statements and Disclaimer on slide 2 regarding risks and uncertainties that could cause actual results to differ. Note: Unique patient prescriptions and NBRx share as of 12/31/2025. GondolaBio is an independent company from BridgeBio. As of December 31, 2025, BridgeBio has a 27.5% stake in GondolaBio. BridgeBio’s interest in GondolaBio is subject to reduction as additional tranches of capital contributions are funded. NSAD=North Star Assessment for Girdle Type Muscular Dystrophies. EPP = Erythropoietic Protoporphyria
Cash burn declined in Q4 2025 relative to Q3 2025, driven by rising revenues and improving operating leverage BridgeBio ended 2025 with $587.5M1 in cash, cash equivalents, and marketable securities We are well-financed to hit a drumbeat of potential milestones in 2026 and beyond 1Represents preliminary, unaudited results as of December 31, 2025, subject to completion of year-end audit procedures. See Forward Looking Statements and Disclaimer on slide 2 regarding risks and uncertainties that could cause actual results to differ. ACH=achondroplasia. HCH=hypochondroplasia. CHP=chronic hypoparathyroidism. Dates reflect anticipated timing. 48 1H 2026 Infigratinib: ACH Topline Encaleret: Initiate P2/3 pediatric ADH1 Encaleret: NDA filing BBP-418: NDA filing Encaleret: Initiate P3 CHP trial 2H 2026 Infigratinib: HCH P2 data readout BBP-418: FDA approval and product launch 1H 2027 Encaleret: FDA approval and product launch NEW INFORMATION