8-K

UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section

13 or 15(d) of the Securities Exchange Act of 1934

May 16, 2024

Date of Report (Date of earliest event reported)

Bicycle Therapeutics plc

(Exact name of registrant as specified in its charter)

Registrant’s telephone number, including area code:

+44 1223

261503

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

Securities registered pursuant to Section 12(b) of the Act:

* Not for trading, but only in connection with the listing of the American Depositary Shares on The Nasdaq Stock Market LLC.

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company  ¨

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨

Item 5.07 Submission of Matters to a Vote of Security Holders

Bicycle Therapeutics plc (the “Company”) held its annual general meeting of shareholders (the “AGM”) on May 16, 2024. Each of the proposals set forth below were voted on and duly passed on a poll at the AGM. Detailed descriptions of these proposals and of the voting procedures applied at the AGM are contained in the Company’s definitive proxy statement on Schedule 14A filed with the Securities and Exchange Commission on April 15, 2024.

There were 37,398,107 ordinary shares of the Company represented in person or by proxy at the AGM, constituting approximately 98.19% of the issued and outstanding ordinary shares on May 16, 2024. Proxy appointments which gave the Chairman of the meeting discretion have been included in the “For” total. In accordance with the terms of the deposit agreement by and among the Company, Citibank, N.A. as depositary and holders and beneficial owners of American Depositary Shares (“ADSs”) dated May 28, 2019, holders of ADSs who did not provide the depositary bank with voting instructions on or before the specified deadline were deemed to have instructed the depositary to give a discretionary proxy to a person designated by the Company to vote the underlying ordinary shares at the AGM and the voting results below reflect that designation. A vote withheld/abstain is not a vote in law and is not counted in the calculation of votes for or against a resolution.

Ordinary Resolutions

Proposal 1 – To re-elect as a directorKevin Lee.

Proposal 2 – To re-elect as a directorJose-Carlos Gutierrez-Ramos.

Proposal 3 – To approve, on an advisorybasis, the compensation of the Company’s named executive officers, as disclosed in the Company’s definitive proxy statement.

Proposal 4 – To ratify the appointmentof PricewaterhouseCoopers LLP, a limited liability partnership organized under the laws of England, as the Company’s U.S. independentregistered public accounting firm for the year ending December 31, 2024.

Proposal 5 – To re-appoint PricewaterhouseCoopersLLP, a limited liability partnership organized under the laws of England, as the Company’s U.K. statutory auditors, to hold officeuntil the conclusion of the next annual general meeting of shareholders.

Proposal 6 – To authorize the Audit Committeeof the Company’s Board of Directors (the “Board”) to determine the Company’s U.K. statutory auditors’ remunerationfor the year ending December 31, 2024.

Proposal 7 – To receive and adopt theCompany’s U.K. statutory annual accounts and reports for the year ended December 31, 2023.

Proposal 8 – To approve the directors’remuneration report for the year ended December 31, 2023.

Proposal 9 – To authorize the Board toallot shares in the Company or to grant rights to subscribe for or to convert any security into shares in the Company up to a maximumaggregate nominal amount of £1,000,000.

Special Resolutions

Proposal 10 – To authorize the Board toallot equity securities for cash up to a maximum aggregate nominal amount of £1,000,000 pursuant to the authorization in Resolution9 as if U.K. statutory pre-emption rights did not apply.

Proposal 11 – To adopt the new articlesof association in substitution for, and to the exclusion of, the Company’s existing articles of association.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.