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6-K

Burning Rock Biotech Ltd (BNR)

6-K 2025-09-08 For: 2025-09-08
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Added on April 06, 2026

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 6-K

REPORT OF FOREIGN PRIVATE ISSUER

PURSUANT TO RULE 13a-16 OR 15d-16

UNDER THE SECURITIES EXCHANGE ACT OF 1934

For the month of September 2025

Commission File Number: 001-39316

BURNING ROCK BIOTECH LIMITED

(Registrant’s Name)

No.5 Xingdao Ring Road North, International Bio Island

Guangzhou, Guangdong

People’s Republic of China

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F ☒    Form 40-F ☐

INCORPORATION BY REFERENCE

Exhibit 99.1 (excluding the paragraphs under the heading “Non-GAAP Measures,” the table under the heading “Burning Rock Biotech Limited Reconciliations of GAAP and Non-GAAP Results,” and other discussions on non-GAAP measures therein) of this current report on Form 6-K (the “Report”) shall be incorporated by reference into the Company’s registration statements on Form F-3, which became effective on September 30, 2022 (File no. 333-264577).

2

EXHIBIT INDEX

Number Description of Document
Exhibit 99.1 Press release

3

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

Burning Rock Biotech Limited
By: /s/ Yusheng Han
Name: Yusheng Han
Title: Chief Executive officer

Date: September 8, 2025

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EX-99.1

Exhibit 99.1

Burning Rock Reports Second Quarter 2025 Financial Results

GUANGZHOU, China, September 8, 2025—Burning Rock Biotech Limited (NASDAQ: BNR, the “Company” or “Burning Rock”), a company focused on the application of next generation sequencing (NGS) technology in the field of precision oncology, today reported financial results for the three months ended June 30, 2025.

Second Quarter 2025 Financial Results

Total Revenues were RMB148.5 million (US$20.7 million) for the three months ended June 30, 2025, representing a 9.6% increase from RMB135.5 million for the same period in 2024.

Revenue generated from in-hospital business was RMB62.5 million<br>(US$8.7 million) for the three months ended June 30, 2025, representing a 4.4% increase from RMB59.9 million for the same period in 2024, driven by an increase in sales volume from existing hospitals and new contracted partner hospitals.<br>
Revenue generated from central laboratory business was RMB40.9 million (US$5.7 million) for the three months<br>ended June 30, 2025, representing a 16.2% decrease from RMB48.8 million for the same period in 2024, primarily attributable to a decrease in the number of tests, as we continued our transition towards<br>in-hospital testing.
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Revenue generated from pharma research and development services was RMB45.2 million (US$6.3 million) for the<br>three months ended June 30, 2025, representing a 68.1% increase from RMB26.9 million for the same period in 2024, primarily attributable to an increased development and testing services performed for our pharma customers.<br>
--- ---

Cost of revenues was RMB40.5 million (US$5.6 million) for the three months ended June 30, 2025, representing an 0.9% increase from RMB40.1 million for the same period in 2024.

Gross profit **** was RMB108.1 million (US$15.1 million) for the three months ended June 30, 2025, representing a 13.3% increase from RMB 95.4 million for the same period in 2024. Gross margin was 72.8% for the three months ended June 30, 2025, compared to 70.4% for the same period in 2024. By channel, gross margin of central laboratory business was 87.9% for the three months ended June 30, 2025, compared to 78.8% during the same period in 2024, primarily due to a reduction in material and shipping costs resulted from cost optimization and control measures; gross margin of in-hospital business was 74.4% for the three months ended June 30, 2025, compared to 73.6% during the same period in 2024, primarily due to a decreased depreciation; gross margin of pharma research and development services was 56.8% for the three months ended June 30, 2025, compared to 48.2% during the same period of 2024, primarily due to a decreased depreciation and an increase in test volume of higher margin projects.

Non-GAAP gross profit, which excludes depreciation and amortization expenses, was RMB110.5 million (US$15.4 million) for the three months ended June 30, 2025, representing a 8.4% increase from RMB101.9 million for the same period in 2024. Non-GAAP gross margin was 74.4% for the three months ended June 30, 2025, compared to 75.2% for the same period in 2024.

Operating expenses were RMB119.6 million (US$16.7 million) for the three months ended June 30, 2025, representing a 42.1% decrease from RMB206.7 million for the same period in 2024. The decrease was primarily driven by budget control measures and headcount reduction to improve the Company’s operating efficiency.

Research and development expenses were RMB49.8 million (US$6.9 million) for the three months ended<br>June 30, 2025, representing a 23.4% decrease from RMB65.0 million for the same period in 2024, primarily due to (i) a decrease in amortized expense on share-based compensation; and (ii) a decrease in the expenditure for research<br>projects.
Selling and marketing expenses were RMB38.4 million (US$5.4 million) for the three months ended<br>June 30, 2025, representing a 21.5% decrease from RMB48.9 million for the same period in 2024, primarily due to (i) a decrease in staff cost resulted from the reorganization of the sales department and improvement in operating<br>efficiency; and (ii) a decrease in entertainment expense; and (iii) a decrease in depreciation and amortization expense.
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General and administrative expenses were RMB31.4 million (US$4.4 million) for the three months ended<br>June 30, 2025, representing a 66.1% decrease from RMB92.8 million for the same period in 2024, primarily due to an decrease in amortized expense on share-based compensation.
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1

Net loss was RMB9.7 million (US$1.4 million) for the three months ended June 30, 2025, compared to RMB108.0 million for the same period in 2024.

Cash, cash equivalents and restricted cash were RMB455.0 million (US$63.5 million) as of June 30, 2025.

Exchange Rate Information

This press release contains translations of certain Renminbi amounts into U.S. dollars at a specified rate solely for the convenience of the reader. Unless otherwise noted, all translations from Renminbi to U.S. dollars and from U.S. dollars to Renminbi are made at a rate of RMB7.1636 to US$1.00, the exchange rate on June 30, 2025, set forth in the H.10 statistical release of the Federal Reserve Board. The Company makes no representation that the Renminbi or U.S. dollars amounts referred could be converted into U.S. dollars or Renminbi, as the case may be, at any particular rate or at all.

About Burning Rock

Burning Rock Biotech Limited (NASDAQ: BNR), whose mission is to guard life via science, focuses on the application of next generation sequencing (NGS) technology in the field of precision oncology. Its business consists of i) NGS-based therapy selection testing for late-stage cancer patients, and ii) cancer early detection, which has moved beyond proof-of-concept R&D into the clinical validation stage.

For more information about Burning Rock, please visit: ir.brbiotech.com.

Safe Harbor Statement

This press release contains forward-looking statements. These statements constitute “forward-looking” statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and as defined in the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as “will,” “expects,” “anticipates,” “future,” “intends,” “plans,” “believes,” “estimates,” “target,” “confident” and similar statements. Burning Rock may also make written or oral forward-looking statements in its periodic reports to the SEC, in its annual report to shareholders, in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Statements that are not historical facts, including statements about Burning Rock’s beliefs and expectations, are forward-looking statements. Such statements are based upon management’s current expectations and current market and operating conditions, and relate to events that involve known or unknown risks, uncertainties and other factors, all of which are difficult to predict and many of which are beyond Burning Rock’s control. Forward-looking statements involve risks, uncertainties and other factors that could cause actual results to differ materially from those contained in any such statements. All information provided in this press release is as of the date of this press release, and Burning Rock does not undertake any obligation to update any forward-looking statement as a result of new information, future events or otherwise, except as required under applicable law.

Non-GAAP Measures

In evaluating the business, the Company considers and uses non-GAAP measures, such as non-GAAP gross profit and non-GAAP gross margin, as supplemental measures to review and assess operating performance. The presentation of these non-GAAP financial measures is not intended to be considered in isolation or as a substitute for the financial information prepared and presented in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”). The company defines non-GAAP gross profit as gross profit excluding depreciation and amortization. The company defines non-GAAP gross margin as gross margin excluding depreciation and amortization.

The company presents these non-GAAP financial measures because they are used by management to evaluate operating performance and formulate business plans. The company believe non-GAAP gross profit and non-GAAP gross margin excluding non-cash impact of depreciation and amortization reflect the company’s ongoing business operations in a manner that allows more meaningful period-to-period comparisons.

Contact: [email protected]

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Selected Operating Data

As of
June 30,<br>2024 September 30,2024 December 31,2024 March 31,2025 June 30,2025
In-hospital Channel:
Pipeline partner hospitals^(1)^ 29 30 29 30 30
Contracted partner hospitals^(2)^ 59 61 63 63 63
Total number of partner hospitals **** 88 **** 91 **** 92 **** 93 **** 93
^(1)^ Refers to hospitals that are in the process of establishing in-hospital<br>laboratories, laboratory equipment procurement or installation, staff training or pilot testing using the Company’s products.
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^(2)^ Refers to hospitals that have entered into contracts to purchase the Company’s products for use on a<br>recurring basis in their respective in-hospital laboratories the Company helped them establish. Kit revenue is generated from contracted hospitals.
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3

Selected Financial Data

For the three months ended
Revenues June 30,<br>2024 September 30,2024 December 31,2024 March 31,2025 June 30,2025
(RMB in thousands)
Central laboratory channel 48,773 39,984 39,278 38,296 40,861
In-hospital channel 59,872 63,769 43,464 57,687 62,496
Pharma research and development channel 26,888 24,891 43,280 37,099 45,197
Total revenues **** 135,533 **** 128,644 **** 126,022 **** 133,082 **** 148,554 ****
For the three months ended
Gross profit June 30,<br>2024 September 30,2024 December 31,2024 March 31,2025 June 30,2025
(RMB in thousands)
Central laboratory channel 38,424 33,262 33,153 32,191 35,937
In-hospital channel 44,058 46,580 29,563 43,895 46,490
Pharma research and development channel 12,956 12,004 26,706 21,315 25,676
Total gross profit **** 95,438 **** 91,846 **** 89,422 **** 97,401 **** 108,103 ****
For the three months ended
Share-based compensation expenses June 30,<br>2024 September 30,2024 December 31,2024 March 31,2025 June 30,2025
(RMB in thousands)
Cost of revenues 464 289 520 308 280
Research and development expenses 12,008 3,180 3,202 1,800 (270 )
Selling and marketing expenses 1,232 1,917 1,353 1,025 364
General and administrative expenses 54,407 4,732 2,937 1,413 2,005
Total share-based compensation expenses **** 68,111 **** 10,118 **** 8,012 **** 4,546 **** 2,379 ****

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Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

(in thousands, except for number of shares and per share data)

For the three months ended
June 30,<br>2024 September 30,2024 December 31,2024 March 31,2025 June 30,2025 June 30,2025
RMB RMB RMB RMB RMB US
Revenues **** 135,533 **** **** 128,644 **** **** 126,022 **** **** 133,082 **** **** 148,554 **** ****
Cost of revenues **** (40,095 ) **** (36,798 ) **** (36,600 ) **** (35,681 ) **** (40,451 ) )
Gross profit **** 95,438 **** **** 91,846 **** **** 89,422 **** **** 97,401 **** **** 108,103 **** ****
Operating expenses:
Research and development expenses (64,952 ) (49,150 ) (52,203 ) (40,389 ) (49,770 ) )
Selling and marketing expenses (48,907 ) (48,411 ) (46,730 ) (40,888 ) (38,413 ) )
General and administrative expenses (92,794 ) (32,874 ) (37,289 ) (31,303 ) (31,417 ) )
Impairment loss on long-lived assets (35,127 )
Total operating expenses **** (206,653 ) **** (130,435 ) **** (171,349 ) **** (112,580 ) **** (119,600 ) )
Loss from operations **** (111,215 ) **** (38,589 ) **** (81,927 ) **** (15,179 ) **** (11,497 ) )
Interest income 3,187 3,173 1,814 2,581 2,226
Other (expense) income, net (82 ) 1 4,353 (652 ) 387
Foreign exchange gain (loss), net 262 (129 ) (220 ) (26 ) (574 ) )
Loss before income tax **** (107,848 ) **** (35,544 ) **** (75,980 ) **** (13,276 ) **** (9,458 ) )
Income tax expenses (190 ) (201 ) (5,314 ) (224 ) (244 ) )
Net loss **** (108,038 ) **** (35,745 ) **** (81,294 ) **** (13,500 ) **** (9,702 ) )
Net loss attributable to Burning Rock Biotech Limited’s shareholders **** (108,038 ) **** (35,745 ) **** (81,294 ) **** (13,500 ) **** (9,702 ) )
Net loss attributable to ordinary shareholders **** (108,038 ) **** (35,745 ) **** (81,294 ) **** (13,500 ) **** (9,702 ) )
Loss per share for class A and class B ordinary shares:
Class A ordinary shares - basic and diluted **** (1.05 ) **** (0.35 ) **** (0.79 ) **** (0.13 ) **** (0.09 ) )
Class B ordinary shares - basic and diluted **** (1.05 ) **** (0.35 ) **** (0.79 ) **** (0.13 ) **** (0.09 ) )
Weighted average shares outstanding used in loss per share computation:
Class A ordinary shares - basic and diluted 85,271,858 85,902,670 86,036,286 90,291,658 90,357,970
Class B ordinary shares - basic and diluted 17,324,848 17,324,848 17,324,848 17,324,848 17,324,848
Other comprehensive income (loss), net of tax of nil:
Foreign currency translation adjustments 940 (4,054 ) 6,009 (72 ) (243 ) )
Total comprehensive loss **** (107,098 ) **** (39,799 ) **** (75,285 ) **** (13,572 ) **** (9,945 ) )
Total comprehensive loss attributable to Burning Rock Biotech Limited’sshareholders **** (107,098 ) **** (39,799 ) **** (75,285 ) **** (13,572 ) **** (9,945 ) )

All values are in US Dollars.

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Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

(in thousands, except for number of shares and per share data)

For the six months ended
June 30,<br>2024 June 30,<br>2025 June 30,2025
RMB RMB US
Revenues **** 261,156 **** **** 281,636 **** ****
Cost of revenues **** (80,024 ) **** (76,132 ) )
Gross profit **** 181,132 **** **** 205,504 **** ****
Operating expenses:
Research and development expenses (130,937 ) (90,159 ) )
Selling and marketing expenses (95,763 ) (79,301 ) )
General and administrative expenses (191,475 ) (62,720 ) )
Total operating expenses **** (418,175 ) **** (232,180 ) )
Loss from operations **** (237,043 ) **** (26,676 ) )
Interest income 7,225 4,807
Other income (expense), net 352 (265 ) )
Foreign exchange gain (loss), net 249 (600 ) )
Loss before income tax **** (229,217 ) **** (22,734 ) )
Income tax expenses (370 ) (468 ) )
Net loss **** (229,587 ) **** (23,202 ) )
Net loss attributable to Burning Rock Biotech Limited’s shareholders **** (229,587 ) **** (23,202 ) )
Net loss attributable to ordinary shareholders **** (229,587 ) **** (23,202 ) )
Loss per share for class A and class B ordinary shares:
Class A ordinary shares - basic and diluted (2.24 ) (0.22 ) )
Class B ordinary shares - basic and diluted (2.24 ) (0.22 ) )
Weighted average shares outstanding used in loss per share computation:
Class A ordinary shares - basic and diluted 85,246,969 90,324,997
Class B ordinary shares - basic and diluted 17,324,848 17,324,848
Other comprehensive income (loss), net of tax of nil:
Foreign currency translation adjustments 1,530 (315 ) )
Total comprehensive loss **** (228,057 ) **** (23,517 ) )
Total comprehensive loss attributable to Burning Rock Biotech Limited’sshareholders **** (228,057 ) **** (23,517 ) )

All values are in US Dollars.

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Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets

(In thousands)

As of
December 31,2024 June 30,<br>2025 June 30,2025
RMB RMB US
ASSETS
Current assets:
Cash and cash equivalents 519,849 452,721
Restricted cash 2,313 2,303
Accounts receivable, net 152,013 189,969
Contract assets, net 13,855 14,755
Inventories, net 62,625 57,810
Prepayments and other current assets, net 25,963 23,254
Total current assets **** 776,618 **** 740,812
Non-current assets:
Property and equipment, net 47,152 38,968
Operating<br>right-of-use assets 53,188 38,168
Intangible assets, net 421 352
Other non-current assets 7,926 6,631
Total non-current assets **** 108,687 **** 84,119
TOTAL ASSETS **** 885,305 **** 824,931

All values are in US Dollars.

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Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets (Continued)

(in thousands)

As of
December 31,2024 June 30,<br>2025 June 30,2025
RMB RMB US
LIABILITIES AND SHAREHOLDERS’ EQUITY
Current liabilities:
Accounts payable 33,747 32,164
Deferred revenue 117,895 102,800
Accrued liabilities and other current liabilities 89,498 75,120
Customer deposits 592 592
Current portion of long-term borrowings 200
Current portion of operating lease liabilities 24,567 19,255
Total current liabilities **** 266,299 **** **** 230,131 **** ****
Non-current liabilities:
Long-term borrowings **** **** 1,800
Non-current portion of operating lease<br>liabilities 27,754 17,871
Other non-current liabilities 10,425 10,894
Total non-current liabilities **** 38,179 **** **** 30,565 **** ****
TOTAL LIABILITIES **** 304,478 **** **** 260,696 **** ****
Shareholders’ equity:
Class A ordinary shares 124 124
Class B ordinary shares 21 21
Additional paid-in capital 5,002,255 5,006,839
Treasury stock (63,264 ) (60,923 ) )
Accumulated deficits (4,200,261 ) (4,223,463 ) )
Accumulated other comprehensive loss (158,048 ) (158,363 ) )
Total shareholders’ equity **** 580,827 **** **** 564,235 **** ****
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY **** 885,305 **** **** 824,931 **** ****

All values are in US Dollars.

8

Burning Rock Biotech Limited

Unaudited Condensed Statements of Cash Flows

(in thousands)

For the three months ended
June 30,2024 June 30,<br>2025 June 30,2025
RMB RMB US
Net cash used in operating activities (40,836 ) (44,349 ) )
Net cash (used in) generated from investing activities (227 ) 207
Net cash generated from financing activities 2,000
Effect of exchange rate on cash, cash equivalents and restricted cash 1,436 (240 ) )
Net decrease in cash, cash equivalents and restricted cash **** (39,627 ) **** (42,382 ) )
Cash, cash equivalents and restricted cash at the beginning of period 572,674 497,406
Cash, cash equivalents and restricted cash at the end of period **** 533,047 **** **** 455,024 **** ****
For the six months ended
June 30,<br>2024 June 30,<br>2025 June 30,2025
RMB RMB US
Net cash used in operating activities (81,045 ) (67,876 ) )
Net cash used in investing activities (2,613 ) (1,324 ) )
Net cash generated from financing activities 2,000
Effect of exchange rate on cash, cash equivalents and restricted cash 1,489 62
Net decrease in cash, cash equivalents and restricted cash **** (82,169 ) **** (67,138 ) )
Cash, cash equivalents and restricted cash at the beginning of period 615,216 522,162
Cash, cash equivalents and restricted cash at the end of period **** 533,047 **** **** 455,024 **** ****

All values are in US Dollars.

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Burning Rock Biotech Limited

Reconciliations of GAAP and Non-GAAP Results

For the three months ended
June 30,<br>2024 September 30,2024 December 31,2024 March 31,<br>2025 June 30,2025
(RMB in thousands)
Gross profit:
Central laboratory channel 38,424 33,262 33,153 32,191 35,937
In-hospital channel 44,058 46,580 29,563 43,895 46,490
Pharma research and development channel 12,956 12,004 26,706 21,315 25,676
Total gross profit **** 95,438 **** **** 91,846 **** **** 89,422 **** **** 97,401 **** **** 108,103 ****
Add: depreciation and amortization:
Central laboratory channel 1,226 1,277 1,010 562 456
In-hospital channel 824 798 623 290 389
Pharma research and development channel 4,417 3,846 2,534 2,412 1,528
Total depreciation and amortization included in cost of revenues **** 6,467 **** **** 5,921 **** **** 4,167 **** **** 3,264 **** **** 2,373 ****
Non-GAAP gross profit:
Central laboratory channel 39,650 34,539 34,163 32,753 36,393
In-hospital channel 44,882 47,378 30,186 44,185 46,879
Pharma research and development channel 17,373 15,850 29,240 23,727 27,204
Total non-GAAP gross profit **** 101,905 **** **** 97,767 **** **** 93,589 **** **** 100,665 **** **** 110,476 ****
Non-GAAP gross margin:
Central laboratory channel 81.3 % 86.4 % 87.0 % 85.5 % 89.1 %
In-hospital channel 75.0 % 74.3 % 69.5 % 76.6 % 75.0 %
Pharma research and development channel 64.6 % 63.7 % 67.6 % 64.0 % 60.2 %
Total non-GAAP gross margin **** 75.2 % **** 76.0 % **** 74.3 % **** 75.6 % **** 74.4 %

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