6-K

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON D.C. 20549

FORM 6-K

Report ofForeign Private Issuer

Pursuant to Rule 13a-16 or15d-16 of

the Securities Exchange Act of 1934

September 14, 2022

CHINASOUTHERN AIRLINES COMPANY LIMITED

68 Qi Xin Road

Guangzhou, 510403

People’s Republic of China

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F  ☒            Form 40-F  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):  ☐

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes  ☐            No  ☒

If “Yes” is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b):  N/A

China Southern Airlines Company Limited (the “Company”) published the following announcement on September 13, 2022 on the Hong Kong Stock Exchange’s website at:

https://www1.hkexnews.hk/listedco/listconews/sehk/2022/0913/2022091300830.pdf, in relation to approval by issuance examination committee of CSRC of the application for the non-public issuance of A Shares of the Company.

The announcement in English is included as an exhibit to this Form 6-K.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

EX-99.1

Exhibit 99.1

Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement, make norepresentation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement.

This announcement appears for information purposes only and does not constitute an invitation or offer to acquire, purchase or subscribe for securities ofChina Southern Airlines Company Limited.

(a joint stock limited company incorporated in the People’s Republic of China with limitedliability)

(Stock Code: 1055)

ANNOUNCEMENT IN RELATION TO APPROVAL BY

ISSUANCE EXAMINATION COMMITTEE OF CSRC OF THE

APPLICATION FOR THE NON-PUBLIC ISSUANCE OF

A SHARES OF THE COMPANY

References are made to the announcements of China Southern Airlines Company Limited (the “Company”) dated 29 October 2021, 10 January 2022 and 10 August 2022 (the “Announcements”) and the circular of the Company dated 11 November 2021 (the “Circular”) in relation to, amongst others, the A Share Issuance of the Company. Unless otherwise defined, capitalised terms used herein shall have the same meaning as those defined in the Announcements and the Circular.

On 13 September 2022, the Issuance Examination Committee of the CSRC reviewed the application of the Company for the A Share Issuance. According to the results of the review, the Company’s application for the A Share Issuance has been approved.

Currently, the Company has not received the written approval from the CSRC. The Company will make further announcement upon receipt of the official approval document from the CSRC.

Shareholders and potential investors are advised to exercise caution when dealing in the shares of the Company, and are recommended to seek professionaladvice if they are in any doubt about their position and as to actions that they should take.

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Guangzhou, the People’s Republic of China

13 September 2022

As at the date of this announcement,the Directors include Ma Xu Lun and Han Wen Sheng as executive Directors; and Liu Chang Le, Gu Hui Zhong, Guo Wei and Yan Andrew Y as independent non-executive Directors.

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