Earnings Call Transcript - CTMX Q4 2022

Operator, Operator

Good day and thank you for standing by. Welcome to the CytomX Therapeutics Fourth Quarter 2022 Financial Results Conference Call. At this time, all participants are in a listen-only mode. After the speakers’ presentation, there will be a question-and-answer session. Please be advised that today's conference is being recorded. I would now like to hand the conference call over to your speaker for today, Chris Ogden. Please go ahead.

Chris Ogden, Speaker

Thank you. Good afternoon and thank you for joining us. Before we begin, I'd like to remind everyone that during this call, we will be making forward-looking statements. Because forward-looking statements relate to the future, they are subject to inherent uncertainties and risks that are difficult to predict and many of which are outside of our control. Important risks and uncertainties are set forth in our most recent public filings with the SEC at sec.gov. We undertake no obligation to update any forward-looking statements whether as a result of new information, future developments or otherwise. Earlier this afternoon we issued a press release that includes a summary of our 2022 full year financial results and highlights recent developments at CytomX. We encourage everyone to read today's press release and the associated materials, which include the 2022 10-K and 2021 amended 10-K, which have been filed today with the SEC. Please also note, the comments made in this call regarding the company’s financials reflect restated financial statements as outlined in our most recent SEC filings today. The adjusted financial statements reflect changes in the timing of certain revenue recognition in the years from 2019 to 2022. Additionally, the press release, a recording of this call and our SEC filings can be found under the Investors and News section of our website. With me on the call today is Dr. Sean McCarthy, CytomX's Chief Executive Officer and Chairman. Sean will provide a business and pipeline update before I walk through the financials for 2022. With that, let me turn the call over to Sean.

Sean McCarthy, CEO

Thanks, Chris, and good afternoon, everyone. Thanks for joining us for an update on recent progress at CytomX. On today's call, I'll provide an overview of the company's therapeutic pipeline, including status updates for our emerging programs, CX-904, CX-801 and CX-2051. I'll also cover recent developments within our CD71 targeting program and additional updates on our corporate partnerships. At CytomX, we believe that as biologic anticancer therapies become more and more potent, the need for localizing empowered modalities such as antibody-drug conjugates, T-cell engagers and cytokines into cancer tissue becomes increasingly important as a way to improve therapeutic window. Indeed, we believe that localization will be the future of biologics. CytomX vision is to transform lives with safer, more effective therapies. We aim to realize our vision for the benefit of patients by leveraging our Probody platform to create high impact therapeutics that are localized to diseased tissue, thereby reducing systemic toxicities and maximizing overall benefit. 2022 was an important year of transition for our company in which we restructured and repositioned CytomX for future success by prioritizing our earlier stage portfolio that incorporates learning from our experience with the first wave of Probody therapeutics that we pioneered and advanced into the clinic. Since our early years, CytomX has pursued a consistent strategy focused on long-term company building around the Probody platform and maximizing impact for patients. Our substantial investments to date have allowed for broad clinical evaluation of our platform, resulting in a uniquely strong scientific foundation and a deep pipeline of therapeutic candidates positioned to deliver significant near and long-term value. We currently have more than 15 active Probody therapeutic programs, including three clinical stage molecules and we expect to file two new INDs for wholly owned programs later this year. Additionally, through our collaborations, we have substantially extended the reach of our science. CytomX entered 2023 with robust financial resources and funding into 2025, positioning the company to execute towards multiple milestones over the next 12 to 24 months. Moving now to our pipeline, I'd like to start with T-cell engaging bispecifics and our company is expanding efforts with this modality. T-cell engagers hold tremendous promise for the treatment of solid tumors. However, the very potency of this modality can lead to widespread activation of the immune system, imposing constraints on therapeutic window. Localization of the powerful anticancer activity of this class of drugs could unlock enormous potential for patients by enhancing therapeutic window. CytomX and our partners believe the Probody platform to be ideally suited to addressing this challenge. Our lead program in this area is CX-904, a clinical stage Probody T-cell engager targeting EGFR and CD3 partnered with Amgen in a global co-development alliance. EGFR is a highly validated and broadly expressed cancer target and we see a compelling opportunity to leverage this target to localize anti-tumor T cell responses preferentially to the tumor microenvironment. Our published preclinical data show that a localized bispecific EGFR CD3 Probody has a widened therapeutic window compared to its unmasked counterpart. These preclinical data led to the advancement of CX-904 and we're now well underway with Phase 1 dose escalation. The Phase 1 study has advanced from initial single patient cohorts into the 3+3 phase of dose escalation. The primary goal of dose escalation for this drug candidate is to assess safety and we aim to reach dose levels and exposures by the end of 2023, which we can start enrollment into back law cohorts in certain EGFR positive tumors. Looking ahead to 2024, a key milestone on the horizon will be the selection of recommended Phase 2 dose and the potential decision to initiate Phase 1b expansion cohorts in EGFR positive tumors. This decision will be taken in conjunction with our partner Amgen. CytomX would then be responsible for the execution of expansion cohorts and upon the conclusion of the expansion phase, Amgen will take over global development with CytomX retaining certain co-funding, co-development, and co-commercialization rights. We look forward to providing additional CX-904 updates as the program advances. Staying with T cell engagers, we were delighted that in January 2023, our partner Astellas nominated the first collaboration clinical candidate triggering a $5 million milestone payment to CytomX. CytomX and Astellas are also collaborating on additional T cell engagers and CytomX is eligible to receive future preclinical, clinical and commercial milestones across these programs. We also retain the option to select U.S. development and commercial rights within the Astellas collaboration. Continuing with T cell bispecifics, in November 2022, CytomX has had a multi-target R&D collaboration with Regeneron to discover and develop new bispecific immunotherapies. Regeneron has considerable efforts in T cell bispecifics and both companies see opportunities to broaden the reach of T cell engagers by utilizing the CytomX platform to localize these highly potent agents to tumor tissue, widening therapeutic window. This shared vision formed the basis of our discussions last year, leading to the deal we announced in November. Given Regeneron's acknowledged high bar for external innovation, this collaboration is yet another point of validation of CytomX scientific and platform expertise. Moving now to our upcoming INDs for next generation molecules CX-2051 and CX-801. Starting with CX-2051, our conditionally active Probody ADC targeting EpCAM. EpCAM has been regarded as a high potential target for decades and has been clinically validated by others, but clinical activity has only been achieved with local administration. CX-2051 is tailored to optimize therapeutic index for EpCAM expressing epithelial cancers by matching the target with payload mechanism of action and tumor sensitivity. We have optimized masking, protease cleavability, and we have selected a camptothecin derivative, topoisomerase 1 inhibitor in the camptothecin class as the payload for this program with a drug antibody ratio of 8. The EpCAM payload class has shown exciting clinical results with ADCs, including HER2 and Trodelvy, and we really think this payload is an optimal choice for this program. Although locally administered anti-EpCAM therapeutics have shown promise, efforts to generate systemic anti-EpCAM therapeutics have to date not been successful. CX-2051, however, when systemically administered has demonstrated a wide predicted therapeutic index and strong preclinical activity in multiple preclinical models, including colorectal cancer. We anticipate filing an IND for this novel ADC in the second half of 2023. Turning now to CX-801, our dually masked interferon alpha-2b, the lead program within our broad efforts in the cytokine field. We believe there's enormous potential to harness the powerful anti-cancer activity of cytokines by using our localization strategies to direct their activity towards tumor tissue and away from systemic immune system activation. Interferon alpha-2b is an approved immunotherapeutic that has demonstrated clinical activity in multiple cancer types, and we believe provides a potentially superior approach to activating anti-tumor immune responses than cytokines such as IL-2, IL-12 and IL-15. Interferon alpha stimulates antigen-presenting cells to activate cytotoxic T cells and combines effectively with checkpoint inhibition, offering tremendous potential to unlock checkpoint refractory and/or resistant cancers. Interferon alpha also has direct tumor cell killing activity, providing a dual mechanism of action. However, the powerful anti-cancer activity of interferon alpha has thus far been difficult to harness due to its systemic toxicity. In data presented at December 16, 2022, we demonstrated that CX-801 has a wide therapeutic index and an enhanced tolerability profile compared to unmasked interferon. Our data have highlighted CX-801's preferential activity in the tumor microenvironment as well as the potential for synergistic effects when combined with checkpoint inhibitors. We believe CX-801 has the potential to become a unique centerpiece of combination therapy for a wide range of tumor types, and we aim to rapidly advance this potentially best-in-class program towards clinical evaluation with an IND filing targeted for the second half of 2023. Let me turn now to our CD71 program. At CytomX, we have had a long-standing interest in leveraging the unique molecular properties of CD71, the transferrin receptor as an anti-cancer target. Our goal is to use our Probody platform to open a therapeutic window for this high potential, but previously undruggable target. And as such, we have developed an antibody drug conjugate to CD71 that we call CX-2029. We partnered the program with AbbVie back in 2016, and that was focused on the advancement of CX-2029 into IND-enabling and clinical studies. Under the collaboration agreement, CytomX was responsible for early development up to the completion of cohort expansions with AbbVie being responsible for later-stage development. We have made substantial progress since this alliance started, and in January this year, we announced updated results from the cohort expansions, which included encouraging clinical activity in unselected heavily pretreated patients with tumors of squamous histologies, including a 21% confirmed response rate in squamous esophageal cancer. Grade 3 anemia remains the most common treatment-related adverse event. Strategies for management of anemia have included transfusions, dose delays and dose reductions. Patients who have responded to CX-2029 have been actively managed through the use of anemia mitigation measures. Our January data update for CX-2029 essentially marks the conclusion of CytomX's responsibilities for execution of the clinical program within the AbbVie alliance, and the data has been under evaluation at AbbVie in recent months. AbbVie informed us on March 21 that they do not plan to advance CX-2029 into further clinical studies for strategic portfolio reasons, and the alliance will conclude. CytomX regains full rights to CD71 and has an exclusive option to reacquire full rights to CX-2029, and these discussions are underway. While we are disappointed with AbbVie's decision, in our work to date on CD71, we have pushed new scientific boundaries and demonstrated for the first time that targeting CD71 with an antibody drug conjugate can lead to tumor shrinkage in late-stage cancer patients. Going forward, CytomX will be evaluating next steps for CX-2029 while also continuing to pursue next-generation strategies to targeting CD71. We would like to thank AbbVie for their partnership in helping us bring CX-2029 and our CD71 program to this stage in its development. I'd like to now briefly update on our collaborative work with Bristol Myers Squibb and Moderna. Our alliance with BMS has continued to make progress, and I would like to take a few minutes to cover the latest updates on the CTLA-4 program. We have worked with BMS on two CTLA-4 Probody approaches. The first is a Probody version of ipilimumab that's called 249. We're also working with BMS on a Probody version of their non-fucosylated anti-CTLA-4 antibody designed to be a more potent version of ipi. This Probody named 288 is designed to be a safer, more effective version of the non-fucosylated ipi. At their earnings call a few weeks ago, BMS announced their prioritization and advancement of the non-fucosylated Probody, 288, which is now the leading edge of their next-generation CTLA-4 program. At SITC in 2022, BMS presented Phase 1 data on 218, which is the non-fucosylated antibody that underlies 288, showing intriguing activity, including in microsatellite-stable colorectal cancer. The 288 Probody is being advanced to Phase 2, and we look forward to future updates from BMS. Lastly, I'd like to reemphasize our most recent collaboration with Moderna, which highlights CytomX's continued innovation, breadth and pioneering efforts in the field of conditional activation and also our continued ability to leverage partnering as a financing vehicle for our company. We're excited to have already kicked off this collaboration, which brings together two leading platforms to research and develop mRNA-encoded conditionally activated biologics. CytomX and Moderna share a vision of investing at the intersection of biology and technology to transform the lives of patients in oncology and also in non-oncology therapeutic areas, and we look forward to doing great things together. Let me now turn the call over to Chris to provide you with a financial overview for the quarter.

Chris Ogden, Speaker

Thank you, Sean. I'm pleased to share an update on our 2022 financial results with you today. CytomX entered 2023 with a strong balance sheet with $194 million in cash, cash equivalents and investments as of December 31, 2022, which we project will fund the operations of the company into 2025. This amount includes the upfront payment received as part of the Regeneron collaboration but does not include the upfront payment of $35 million received in Q1 2023 from Moderna. We continue to operate from a position of financial strength, and our recent collaborations continue to highlight CytomX's ability to leverage its differentiated science to bring capital into the company and build long-term value. Moving to the financials for the full year 2022. I would like to note that my comments regarding the financial statements refer to our most recent SEC filings, which include restated financial information from 2019 to 2022 as a result of a change in our revenue recognition accounting method for certain collaboration agreements. The restatement impacts the timing of certain revenue recognition and does not impact total revenue that will be recognized for each collaboration. Also, the restatement has no impact on the company's current cash position or cash flows. Revenue in 2022 was $53.2 million compared to $37.3 million in 2021, driven by higher estimated percentages of completion for research and development programs in the company's collaborations with AbbVie and Bristol Myers Squibb. R&D expenses decreased by $2.5 million to $111.6 million in 2022. The decrease was primarily due to lower clinical trials and lab contract services, partially offset by $5.3 million of restructuring expenses. G&A expenses increased $3.6 million in 2022 to $42.8 million, driven primarily by $2.4 million of restructuring expenses. Overall, full year 2022 expenses related to the company's restructuring, which was announced in July of 2022 were $7.7 million. The restructuring is substantially complete as of the end of 2022. With that, I'll turn the call back to Sean.

Sean McCarthy, CEO

Thanks, Chris. In summary, CytomX has begun 2023 with strong execution across the pipeline and with considerable momentum. This will continue to be a year of focused execution by the company across our partnered and wholly-owned pipeline. Our progress with CX-904, taken together with our exciting collaborative efforts with Regeneron and Astellas positions the company with significant ongoing efforts in T cell engagers and an opportunity to make an important impact in one of the most promising areas of oncology R&D. We also continue to invest in cancer immunotherapy strategies through our work on CX-801, our conditionally active interferon alpha, which is on track for IND filing this year. As we assess potential next steps for the CX-2029 asset and our CD71 program more broadly, we're also excited to advance our latest ADC, CX-2051 targeting EpCAM towards IND filing. The translational cycle of bench to bedside to bench has continued to teach us where the highest impact applications of our technology lie for the benefit of people with cancer and we remain strongly committed to our patients. I would like to extend my sincere thanks to the CytomX team for their ongoing dedication and commitment to our vision and mission. Operator, let's now open the call up for Q&A.

Operator, Operator

Thank you. The first question we have is coming from Roger Song, Jefferies. Your line is open.

Roger Song, Analyst

Great. Thank you for taking the question. Many thanks for the update. A couple of questions from us, maybe start from the 904. Sean, you mentioned you potentially will go through the dose escalation by the end of this year and moving into the expansion next year. So, can you just give us some kind of comment around what should we expect to see in terms of the data update from that program and what are the key criteria for you to move into the tumor specific expansion? Thank you.

Sean McCarthy, CEO

Thank you for the question, Roger. We're pleased with the progress in the early program for 904. Currently, we are engaged in dose escalation to evaluate the safety of this novel T cell engager. Our aim is to reach doses by the end of the year that will allow us to begin backfilling cohorts, which is typical in early Phase 1 trials. Given the nature of this molecule, as with any T cell engager, we are being cautious with the stepwise dose escalation since these are highly potent compounds. With the FDA's guidance on Optimus and considerations for maximum tolerated dose and recommended phase 2 dose, we will take a careful approach. While we can't provide a timeline for data, we are making good progress.

Roger Song, Analyst

Okay. That's fair. And then so in terms of your upcoming R&D for 801 and 2051, can you just let us know what the status of the IND-enabling studies are, in terms of the EpCAM and paths that you are doing? And also, what are the initial indications for those two, the potential INDs? Thank you.

Sean McCarthy, CEO

Yeah. Thanks for the question. So very excited about these two new INDs. As I've mentioned, they have broad potential across multiple tumor types. And as you mentioned, Roger, the team is very busy right now with IND-enabling activities for both of these programs. We're pleased with the progress. We're on track with manufacturing steps with toxicology programs, and everything remains on track for our guidance for these INDs being filed this year. In terms of tumor types, let's take EpCAM first. One of the things we love about this target is just how broadly expressed it is on epithelial tumors. I did call out colorectal cancer in my comments a few moments ago, as this is the tumor type where EpCAM is the most highly expressed, is very highly expressed in colorectal cancer. That's one of the reasons that we've selected the camptothecin payload, which we think is well matched to that tumor type, given the high target expression as well. But there are many other tumor types that we could potentially move into, including pancreatic, ovarian, to name just two. So many, many different areas to go. We'll be guided by what we see in Phase 1, of course. With regards to 801, interferon has been approved in several tumor types in the past. We already know it's an active drug, it's an approved drug. Our strategy there with 801, given the potency of interferon alpha as an immunotherapy is to work in the area of increasing antitumor immunity, turning colder tumors into warmer tumors, turning warmer tumors into hot tumors and there will be several opportunities to pursue there. But again, we'll be guided by the Phase 1 dose escalation data once we get that up and running.

Roger Song, Analyst

Great. Thanks for the comment. Maybe just one last question, and I will hop back on the queue, is for the CD71. Since you are regaining the rights for this target and potentially for the entire 2029, so you talk about the next generation for CD71, and that we know the anemia is on target kind of probability finding you have been observing. So, can you just let us know what are the key strategies for the next generation, and how you're going to apply from the learning from the previous clinical data to the next generation? Thank you.

Sean McCarthy, CEO

Thank you for your question. To start with the 2029 data, we have an active drug, a novel ADC that has demonstrated antitumor activity across various tumor types, most notably an intriguing signal in squamous esophageal. Over the past year, we've gained insights into anemia and recognize that we still have work ahead to better manage and mitigate it if we decide to advance 2029 ourselves. We've learned a lot from 2029 in recent years, and we believe there is a therapeutic window for the drug. We think that with next-generation advancements, we could widen this therapeutic window. We are exploring different methods to enhance antitumor activity and reduce the incidence of anemia, and we have several ideas in that regard. I expect we'll have more updates on this as the year progresses.

Roger Song, Analyst

Great. Thanks. That’s it for now.

Operator, Operator

Thank you. One moment while we prepare for our next question. And our next question is coming from Mara Goldstein of Mizuho Group. Please go ahead. Your line is open.

Mara Goldstein, Analyst

Great. Thanks for taking the question. So just maybe to clarify a little bit on CX-2029. You have rights to CD71, but you would then have to acquire the CX-2029 molecule if you chose to do that. Is that correct?

Sean McCarthy, CEO

That's right, Mara. The program, as it relates to the target, goes back to CytomX for CX-2029 as a Phase 2 asset. We have exclusive negotiation rights to reclaim full rights from AbbVie, and those discussions have begun.

Mara Goldstein, Analyst

Okay. Fair enough. Under the original AbbVie agreement, they had chosen a second target a couple of years ago. Is that still ongoing or is that no longer active?

Sean McCarthy, CEO

Yeah. So, we had two separate collaborations that were initiated at the same time with AbbVie. One was the CD71 R&D agreement and the other was a research discovery agreement. And that's the collaboration under which a couple of additional targets for ADCs were selected. And that agreement is also coming to a conclusion as well.

Mara Goldstein, Analyst

Okay. Fair enough. And then I wanted to ask, on the Moderna collaboration, I certainly understand it's at an early stage, but can you talk to us a little bit about the sort of visibility from your perspective in terms of what you may or may not be able to speak to, particularly as it relates to where the benchmarks are for CytomX to, A, participate not just financially but also potentially clinically?

Sean McCarthy, CEO

Well, just again to reiterate just how excited we are about the science that we're doing with Moderna that we've just kicked off. So just to recap, the goal of the alliance is to leverage their mRNA platform to encode and express conditionally activated biologics in oncology and non-oncology. We're not ready to disclose additional details of the research program at this point. But the collaboration is structured such that we are responsible for certain discovery and lead authorization efforts, and Moderna will be responsible for development and commercialization with milestones and royalties coming to CytomX. And so, we do not expect to be involved in the development activities with Moderna, unlike, for example, the relationships with AbbVie or even Amgen on 904. This is, in some ways, a more traditional discovery relationship in which Moderna will be conducting the development of the programs as they mature and move forward.

Mara Goldstein, Analyst

Okay. All right. Thanks so much. I appreciate it.

Sean McCarthy, CEO

You’re welcome.

Operator, Operator

Thank you. One moment while we prepare for the next question. Our next question will be coming from Peter Lawson of Barclays. Your line is open.

Unidentified Participant, Analyst

Good afternoon, everyone. Thank you for taking our question. This is Alex substituting for Peter. I have two quick questions about the BMS collaboration. First, could you comment on the main differences you observed in Phase 1 for the 218 molecule compared to the data we've seen for the 249 molecule?

Sean McCarthy, CEO

I'm glad to address that. It takes some time to go through the different components, so please bear with me. The 249 molecule is the Probody version of ipilimumab (ipi), while the 218 is the non-fucosylated antibody developed by BMS. Then we have 288, which is the Probody form of 218. The clinical data previously presented by BMS pertains to the Phase 1 studies of 249 and 218. There is currently no available data on 288, the non-fucosylated Probody. The important insights from the Phase 1 studies for 249 and 218 include that the Probody 249 successfully escalated doses to high levels of the ipi mass, achieving 30 mg per kg as a monotherapy and 15 mg per kg in combination with full dosing. This is consistent with our past clinical work, showing that masking alters the dose-response curve for toxicity, allowing higher doses to be tolerated. Additionally, there was clear evidence of clinical activity for 249, including a response in microsatellite-stable colorectal cancer highlighted in a poster presentation. The 218 poster also showed significant clinical activity, including a case study in microsatellite-stable colorectal cancer, an area of active development by other companies as well. Notably, the 218 drug is more potent than ipi due to its non-fucosylation, allowing for lower administered doses compared to ipi alone. This is an important takeaway. The potential for the masked 288 version of 218 to evaluate higher doses of the non-fucosylated in mask form is significant. However, we do not yet have clarity on BMS' Phase 2 strategy for 288. Those are some insights based on the data presented so far.

Unidentified Participant, Analyst

Okay. Great. That makes a lot of sense. I was also curious if you have any insight regarding whether the current studies with the 249 will stop enrolling patients moving forward. Thank you.

Sean McCarthy, CEO

You’re welcome.

Operator, Operator

Thank you. One moment while we prepare for the next question. Our next question will be coming from Mitchell Kapoor of H.C. Wainwright. Your line is open.

Mitchell Kapoor, Analyst

Hi, Sean and team. Thanks for taking the questions. Hope you are well. I wanted to ask about CX-2029 and the discussions regarding the reacquisition of the rights. What does that involve? Also, how do you think the ability to treat esophageal cancers more effectively compared to other cancers informs us about the drug's profile and mechanism in relation to its target?

Sean McCarthy, CEO

Yeah. Thanks for the questions, Mitch. I can't really comment on the 2029 negotiation for obvious reasons at this point other than to say that those discussions have been initiated, and there's a process laid out in the contract that we negotiated some years ago for how to go about that. So, we'll see where it all goes. With regards to esophageal, it is really interesting to us. The signal that we've seen there, one of the intriguing features of esophageal that relates to the target is published data from others showing or suggesting that CD71 is amplified in certain squamous esophageal tumors. So one could certainly imagine that there's a relationship between target level or more specifically target amplification and clinical activity. That's something that we're aggressively pursuing, as to figure out whether there's a potential patient selection strategy there. Speaking in general terms, of course, given the high incidence of anemia that we have with this drug, plus its clinical activity, if we elect to move the drug forward in esophageal, let’s say, obviously, we’d be wanting to do everything we can to select patients in our favor to increase the likelihood of response and to continue to work to find ways to manage and mitigate anemia to give the drug its best chance of future success. So that’s something that we’re actively looking at that relates directly to the target.

Mitchell Kapoor, Analyst

Okay. Great. Thank you very much for taking my questions.

Sean McCarthy, CEO

You’re welcome.

Operator, Operator

Thank you. One moment while we prepare for the next question. Our next question will be coming from Anupam Rama of JPMorgan. Your line is open.

Malcolm Kuno, Analyst

Hi. Thank you for taking the question. This is actually Malcolm Kuno on for Anupam. Just one quick question. So given that some of your collaborations involve cost-sharing agreements, what should we assume as being baked into your cash runway?

Sean McCarthy, CEO

I'll pass that one over to Chris.

Chris Ogden, Speaker

Yeah. Hi, Malcolm. Just to reiterate what we've communicated on cash runway in the prepared remarks, so we reported $194 million of cash at the end of the year. As I mentioned, that does not include the Moderna upfront payment of $35 million received in Q1 of 2023 nor the Astellas milestone that we achieved of $5 million in January of this year. In terms of color on the guidance, we don't go into specifics on exactly what's assumed. From an overall capital allocation and resourcing perspective, we communicated in the summer of last year the focus on CX-904 and the next-generation pipeline. Of course, capital will be allocated to those programs as appropriate. But beyond that, we're not giving any additional color.

Sean McCarthy, CEO

Yes, I’d like to add something regarding the deal structures. As previously mentioned, both the AbbVie and Amgen partnerships have been organized in a way that following the conclusion of our relationship with Amgen, we now have the chance to invest in later-stage development, although that is still some time away. Therefore, as Chris noted, our current financials and guidance are primarily centered on advancing our earlier-stage programs to bring key near-term assets to fruition.

Malcolm Kuno, Analyst

That makes sense. Thank you.

Operator, Operator

Thank you. One moment while we prepare for the next question. Next question is coming from Etzer Darout of BMO. Your line is open.

Etzer Darout, Analyst

Thank you for the question. I would like to clarify the status of the Probody program from BMS. Is 249 still ongoing and making progress? Is this just an advancement over 288, or is that the only program BMS intends to continue with? That's my first question. Additionally, could you discuss the potential differences in safety and tolerability between 218, the antibody from Bristol, and the adverse event profile associated with ipi, which is known to have significant concerns? Thank you.

Sean McCarthy, CEO

Yeah. Thanks, Etzer. Obviously, questions, I think, are probably better answered by our partner, BMS. But let me just make a couple of brief comments. First of all, with regard to the 288 leapfrog as you put it, they have been clear that they have prioritized 288 over the other programs, and the advancement from Phase 1 to Phase 2 reflects that. I think if one looks at the broad landscape of CTLA-4 next-gens that are being pursued by various parties, there is a move towards more potent versions of anti-CTLA-4 antibodies using strategies like FC enhancement or in the case of BMS, non-fucosylation, which are functionally very similar. Their decision, I think looking at it from the standpoint of the outside world and the way the field is evolving, makes sense to us. With regard to safety of 218, again, I think the question would be much better answered by our partner. I would just observe from the data that we've seen in their presentations that 218, as I mentioned earlier, is a more potent antibody when one thinks about engagement of the target, the target biology. It is less well-tolerated. I think the profile of adverse events that are seen are similar. I'm not aware of anything that's particularly unique with the FC enhanced but we'd have to study the data closely.

Etzer Darout, Analyst

Got it. Thanks for the update.

Sean McCarthy, CEO

Yeah. And the goal of the Probody, of course, is to open that therapeutic window, and that's why we're encouraged that they prioritized 288.

Etzer Darout, Analyst

Got it. Yeah. Thank you.

Sean McCarthy, CEO

You’re welcome.

Operator, Operator

Thank you. That concludes today's Q&A session as well as concludes today's conference call. Thank you all for joining. You may disconnect and have a good evening.