6-K

UNITEDSTATES

SECURITIESAND EXCHANGE COMMISSION

WASHINGTON,D.C. 20549

FORM6-K

REPORTOF FOREIGN PRIVATE ISSUER

PURSUANT TO RULE 13a-16 OR 15d-16 UNDER

THE SECURITIES EXCHANGE ACT OF 1934

Forthe month of May 2022

CommissionFile Number: 001-41115

GENENTASCIENCE S.P.A.

(Translation of registrant’s name into English)

ViaOlgettina No. 58

20132Milan, Italy

(Address of Principal Executive Offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ☐

OtherEvents

On May 10, 2022, the Company issued a notice announcing the date of its Ordinary and Extraordinary Meeting of its Shareholders. Materials relating to its upcoming virtual Ordinary and Extraordinary Meeting of Shareholders will be posted on its website on or about May 20, 2022.

Exhibits

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Dated: May 11, 2022

Exhibit 99.1

GenentaScience S.p.A.

Registeredoffice: Milan, via Olgettina n. 58

Subscribedand paid-up share capital of € 371,685.80

Taxcode and registration number with the Milan Monza - Brianza Lodi Register of Companies: 08738490963

NOTICEOF CALL OF ORDINARY AND EXTRAORDINARY SHAREHOLDERS’ MEETING

The shareholders of Genenta Science S.p.A. (the Company) are invited to participate in the ordinary and extraordinary shareholders’ meeting (the Shareholders’ Meeting) which will take place, in accordance with Article 9.5 of the Company’s Articles of Association (the Articles of Association), exclusively by teleconference, on 10 June 2022 at 2.30 pm, on first call, and if necessary, on 13 June 2022, at 5.30 pm, on second call, to resolve on the following

AGENDA

Ordinarypart:

1. Approval of the financial statements for the year ended 31 December 2021.

2. Ratification of the appointment of Mark A. Sirgo as director and chairman of the Board of Directors.

Extraordinarypart

1. Approval of the amendment to art. 15 of the articles of association in order to include the provision of the U.S. federal forum.

*****

Information on the legitimacy to participate in the Shareholders’ Meeting and exercise of the right to vote as well as those concerning the methods of participation in the Shareholders’ Meeting are reported in the full notice of call, the text of which - together with the documentation relating to the Shareholders’ Meeting – will be available. on the Company’s website at www.genenta.com, as well as at the Company’s registered office in Milan, via Olgettina n. 58.

*****

Milan, 10 May 2022