TWO SIGMA INVESTMENTS, LP

CIK

1179392

City

NEW YORK

State / Country

Stock

NVO — Novo Nordisk A S

Top Portfolio Positions

3,298 positions · $111,953,798,342 total · as of Mar 31, 2026

Ticker	Company	Shares	Value (USD)	% of Portfolio
NVDA	Nvidia Corp Technology	12,053,545	$2,102,138,248	1.88%
AAPL	Apple Inc. Technology	6,085,143	$1,544,348,441	1.38%
GOOGL	Alphabet Inc. Communication Services	4,810,528	$1,383,315,431	1.24%
AMZN	Amazon Com Inc Consumer Cyclical	6,454,567	$1,344,292,669	1.20%
TSLA	Tesla, Inc. Consumer Cyclical	3,116,099	$1,158,409,803	1.03%
JPM	Jpmorgan Chase & Co Financial Services	3,523,588	$1,036,498,646	0.93%
PLTR	Palantir Technologies Inc. Technology	6,809,802	$996,137,836	0.89%
COST	Costco Wholesale Corp /New Consumer Defensive	891,093	$887,911,797	0.79%
TJX	Tjx Companies Inc /De/ Consumer Cyclical	5,277,968	$842,891,489	0.75%
MA	Mastercard Inc Financial Services	1,682,998	$840,926,780	0.75%

25 quarters · across all stocks

25 quarters on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$856,275	23,300	-99.6%	Put	Sole	2026-05-15
2026-03-31	$231,028,911	6,286,501	+5074.1%	Shares	Sole	2026-05-15
2026-03-31	$4,465,125	121,500	-64.6%	Call	Sole	2026-05-15
2025-12-31	$17,461,558	343,191	+160.0%	Shares	Sole	2026-02-17
2025-12-31	$6,716,160	132,000	0.0%	Put	Sole	2026-02-17
2025-12-31	$6,716,160	132,000	-92.2%	Call	Sole	2026-02-17
2025-09-30	$93,862,777	1,691,526	-23.7%	Shares	Sole	2025-11-14
2025-06-30	$153,013,889	2,216,950	-29.6%	Shares	Sole	2025-08-14
2025-03-31	$218,592,189	3,147,929	+70.7%	Shares	Sole	2025-05-15
2024-12-31	$158,657,266	1,844,423	+8439.0%	Shares	Sole	2025-02-14
2023-12-31	$2,234,520	21,600	-0.1%	Shares	Sole	2024-02-14
2023-09-30	$1,967,032	21,630	-93.5%	Shares	Sole	2023-11-14
2023-06-30	$26,836,835	331,667	+993.7%	Shares	Sole	2023-08-14
2023-03-31	$2,413,039	30,326	+237.0%	Shares	Sole	2023-05-15
2022-12-31	$609,030	9,000	-93.0%	Shares	Sole	2023-02-14
2022-06-30	$7,140,824	128,167	+17.8%	Shares	Sole	2022-08-15
2022-03-31	$6,040,176	108,783	-67.6%	Shares	Sole	2022-05-16
2021-12-31	$18,791,640	335,565	-56.7%	Shares	Sole	2022-02-14
2021-09-30	$37,208,627	775,099	+68.5%	Shares	Sole	2021-11-15
2021-06-30	$19,263,958	459,925	+2.2%	Shares	Sole	2021-08-16
2021-03-31	$15,170,814	450,039	-18.5%	Shares	Sole	2021-05-17
2020-12-31	$19,279,123	552,015	+15.0%	Shares	Sole	2021-02-16
2020-09-30	$16,662,158	479,970	-29.8%	Shares	Sole	2020-11-16
2020-06-30	$22,377,626	683,495	+121.6%	Shares	Sole	2020-08-14
2020-03-31	$9,285,669	308,494	—	Shares	Sole	2020-05-15
No 13F history on record for this holder in this stock.