SPHERA FUNDS MANAGEMENT LTD.
Position in RARE — Ultragenyx Pharmaceutical Inc.
CIK 1496201
TEL AVIV, L3
Position in RARE
as of Mar 31, 2026
· filed May 15, 2026
Position Value
$16,955,526
+$10,041,197 QoQ
Shares Held
809,333
+169.2% QoQ
Ownership
0.822%
of shares outstanding
% of Portfolio
2.95%
of 13F equity value
Holder Rank
—
not a current holder
Holding Since
Sep 2022
15 quarters on record
Voting authority
Sole 100.ToString("F0")%
Shared 0.ToString("F0")%
None 0.ToString("F0")%
Common Shares in RARE Over Time
Shares Held
Position Value (USD)
Derivatives in RARE
reported options exposure · as of Dec 31, 2025CallValue
$8,050,000
CallShares
350,000
PutValue
$0
PutShares
0
Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.
Position in Biotechnology
Healthcare · as of Mar 31, 2026SPHERA FUNDS MANAGEMENT LTD. holds $325,221,568 across 61 Biotechnology names. RARE ranks #3 (5.2% of the industry book) .
| # | Ticker | Company | Shares | Value (USD) | Open |
|---|---|---|---|---|---|
| 1 | MLYS |
Mineralys Therapeutics, Inc.
|
1,339,971 | $36,299,814 | |
| 2 | BBIO |
BridgeBio Pharma, Inc.
|
245,246 | $18,211,967 | |
| 3 | RARE |
Ultragenyx Pharmaceutical Inc.
This page
|
809,333 | $16,955,526 | |
| 4 | SNDX |
Syndax Pharmaceuticals Inc
|
724,563 | $16,925,791 | |
| 5 | COGT |
Cogent Biosciences, Inc.
|
416,340 | $16,024,926 | |
| 6 | FOLD |
AMICUS THERAPEUTICS, INC.
|
603,377 | $8,724,831 | |
| 7 | APLS |
Apellis Pharmaceuticals, Inc.
|
214,914 | $8,645,990 | |
| 8 | BMRN |
Biomarin Pharmaceutical Inc
|
139,900 | $7,902,951 |
All Filings in RARE
Export CSV
19 filing rows on record
| Report Date | Value (USD) | Shares | Type | Discretion | Filed | |
|---|---|---|---|---|---|---|
| 2026-03-31 | $16,955,526 | 809,333 | Shares | Defined | 2026-05-15 | |
| 2025-12-31 | $6,914,329 | 300,623 | Shares | Defined | 2026-02-17 | |
| 2025-12-31 | $8,050,000 | 350,000 | Call | Defined | 2026-02-17 | |
| 2025-09-30 | $10,604,944 | 352,558 | Shares | Defined | 2025-11-14 | |
| 2025-06-30 | $3,639,090 | 100,085 | Shares | Defined | 2025-08-14 | |
| 2025-06-30 | $6,566,616 | 180,600 | Call | Defined | 2025-08-14 | |
| 2025-03-31 | $9,682,010 | 267,385 | Shares | Defined | 2025-05-15 | |
| 2025-03-31 | $1,810,500 | 50,000 | Call | Defined | 2025-05-15 | |
| 2024-12-31 | $9,624,606 | 228,776 | Shares | Defined | 2025-02-14 | |
| 2024-09-30 | $10,851,636 | 195,349 | Shares | Defined | 2024-11-14 | |
| 2024-06-30 | $12,076,495 | 293,832 | Shares | Defined | 2024-08-14 | |
| 2024-03-31 | $2,567,950 | 55,000 | Call | Defined | 2024-05-15 | |
| 2024-03-31 | $11,137,619 | 238,544 | Shares | Defined | 2024-05-15 | |
| 2023-12-31 | $9,613,924 | 201,044 | Shares | Defined | 2024-02-15 | |
| 2023-09-30 | $9,238,162 | 259,135 | Shares | Defined | 2023-11-14 | |
| 2023-06-30 | $8,473,896 | 183,696 | Shares | Defined | 2023-08-14 | |
| 2023-03-31 | $7,366,209 | 183,696 | Shares | Defined | 2023-05-15 | |
| 2022-12-31 | $8,510,635 | 183,696 | Shares | Defined | 2023-02-14 | |
| 2022-09-30 | $7,192,751 | 173,696 | Shares | Defined | 2022-11-14 | |
| No filing history on record for this holder in this stock. | ||||||