Transcript
Hi, everyone. I’m Chris Gibson, Co-Founder and CEO of Recursion, and I'm thrilled to have you with us for our Q1 2024 Earnings Call. I want to share some exciting updates from the company over the last quarter as we strive to achieve our mission of decoding biology to significantly enhance lives. Recursion is in a unique position to break through in the TechBio space. We have successfully integrated our pipeline, platform, and people, which gives us the chance to demonstrate a notable shift in the pace, scale, and hopefully the success rate of drug discovery and development in the coming quarters and years. We are proud to lead in TechBio because we have great confidence in our future. We believe that TechBio represents the inevitable direction of biotechnology. With that said, I’m excited to discuss what we’re working on, starting with our pipeline. Our pipeline is particularly thrilling because we are set to showcase catalysts on approximately a quarterly basis. These will commence in Q3 with our first Phase 2 readout and will continue with additional Phase 2 POC readouts quarterly. We will start with REC-994, the SYCAMORE trial focused on cerebral cavernous malformation. This is a first-in-disease initiative, and as the first institutionally sponsored program to progress through the FDA, we are nearing completion of the study and are almost done enrolling patients for a long-term extension. In this trial, we will examine all evidence from various exploratory endpoints, focusing on safety and tolerability and several potential efficacy outcomes that could allow us to work with the FDA to expedite bringing this medicine to patients. Following that, we will have REC-2282 for neurofibromatosis type 2, where we expect to report preliminary safety and efficacy results in Q4. Next is REC-4881, with a preliminary readout expected in the first half of 2025, and another REC-4881 program also projected for a preliminary readout in the first half of 2025. Additionally, we have several other programs set to initiate Phase 2 studies or move toward IND submission shortly. We are genuinely enthusiastic about this pipeline as it offers Recursion a distinct opportunity to robustly demonstrate progress. We understand that not all these programs will succeed, but we are hopeful that some will. Ultimately, what excites us is not just the chance to deliver medicines to patients, especially those that are first-in-disease, but also the ability to learn from these trials. Regardless of whether they are successful or not, we can refine our platform with the data we gather. We are committed to a long-term journey to develop what we envision as the defining TechBio company of the future. Along with our pipeline, we are equally excited about our platform, and we are eager to announce a new deal similar to the one we made with Tempus back in December, this time with Helix... ...that's going to give us access to hundreds of thousands of de-identified records along with omics data that we can put together with all of the rest of the data we generated at Recursion and start to continue to train these causal AI models to help understand the gene networks that are underlying now, not only oncology diseases but also non-oncology diseases. And what's fantastic about this collaboration is that, as you know, we've got large partnerships in the context of Roche-Genentech and neuroscience and maybe other partnerships coming down the line in non-oncology areas and this collaboration will allow us to be generating even more robust hypotheses using patient data to help drive our really, really exciting platform internally. So very excited to announce this collaboration with the Helix team, a multiyear collaboration here, and we're going to be kicking that off imminently. Second, we shared this on social a couple of weeks ago, but I just want to emphasize. Recursion pioneered the use of phenomics to try and understand biology, but we now also have started to scale multiple other layers of omics, transcriptomics, working on proteomics. We have enviromics. We have the patient data, like I just talked about, but I really want to emphasize here our work in transcriptomics. We've now sequenced our one millionth transcriptome at Recursion and we are leveraging our unique take on doing transcriptomes in order to work across a whole genome, transcriptomic map, the first of potentially many in that space and also starting to layer in data from transcriptomics across chemical perturbations as well. We think this will be a really exciting orthogonal data layer to what we're building with phenomics, what we're going to build with proteomics, what we're building with enviromics in the animal organism step and what we've got with genome scale, population scale data, not only with Tempus but now with Helix. And so not only are we training our AI models within each of these data layers, but increasingly starting to train AI models between and across these different data layers, these multimodal omics data sets that we're generating, I think, pretty uniquely here at Recursion. So really exciting, and congratulations to the team for the incredible scale that they put together with our transcriptomics technology... ...Finally, another exciting opportunity on the platform side, we've really been leaning into active learning over the past quarter. And I think you're going to see us continue to increase the cadence of this work as research work coming out of the team at Valence Labs and being done here at Recursion, which is allowing us to move away from having to do every experiment towards making predictions about what experiment would give us the highest amount of learning and what you can see here is one of our early pilots looking across just about 50 or 100 genes where by using this iterative approach of active learning, we can get about 80% of the value, 80% of the information you see on that top line only doing about 40% of the experiments. And we think this is going to be a transformational tool for us to deploy with our unique scaled wet lab environment because what this is going to allow us to do is start to explore this incredible sort of high-dimensional space of biological perturbations, chemical perturbations, time-based perturbations across multiple different layers of omics and it starts to become trillions and trillions and trillions, in fact, trillions times, trillions times, trillions of different possible combinations one could explore, far too much to ever brute force and using these kinds of tools and technologies we're building out of Recursion. I think we're going to be uniquely positioned to do the best next experiment to use our resources in the most efficient way to broadly map drug discovery, to broadly map biology, to broadly map chemistry, and ultimately bring medicines to patients more quickly... ...And then I also want to talk a little bit about some exciting news around BioHive 2. Again, we announced a little bit of this on social. We partnered with NVIDIA last year. They brought an equity investment in. And since then, we've been working so closely with that team, announced in the fall that we were going to build BioHive 2 to our next supercomputer. You can see here that we actually now have built out this supercomputer. We benchmarked the supercomputer at 23.32 petaflops, we did that once all the materials were in place, we built it out and benchmarked it in three weeks, thanks to an incredible partnership with the NVIDIA team. If we were to take that benchmark and compare it to the previous top 500 list, it would put us right around 30th position there. So we'll see as the new top 500 list comes out where we end up probably in the top 50. But this means Recursion now owns and operates the two of the fastest supercomputers in all of biopharma will be combining BioHive 1 with BioHive 2, we'll rebenchmark that later and see if we can continue to move up the path. But I think in the in the space of TechBio, where we know scaling law supply, where we know both data and computer are going to be critical recursion, really uniquely positioned with one of the most compelling data sets, one of the fastest-growing data sets, one of the most purpose-built for machine learning data sets alongside one of the most robust sets of on-premise compute in the industry. Putting those two things together, we think gives us a really, really robust mode. So kudos to the team for all of their hard work getting this done... I want to conclude by discussing our people since, without them, we cannot advance our mission. In the last quarter, we made significant announcements. First, Najat Khan, a prominent figure in TechBio, has joined us from Johnson & Johnson. She is already a member of our Board of Directors and will transition to the role of Chief R&D Officer and Chief Commercial Officer at Recursion in the next six to ten weeks. She brings exceptional expertise in everything from hit and target discovery to leveraging digital tools for commercialization, marketing, and distribution. Her comprehensive understanding of drug discovery and development, combined with her experience in pipeline strategy at Johnson & Johnson—one of the leaders in digital innovation in the biopharma sector—makes us thrilled to welcome Najat to Recursion, and we eagerly anticipate the next phase with her. Additionally, we announced that Michael Bronstein, a professor of artificial intelligence at Oxford, will join us as a Recursion valence adviser. We are excited to meet him in London in a few weeks as we officially open our London office, where we see a tremendous opportunity to tap into the outstanding talent in computational biology that exists there, furthering our mission at Recursion. Before I move to questions, I just want to end with some high-level guidance, I think, as I shared before, Recursion really uniquely leading TechBio. We believe that over the coming quarters and coming years, I think Recursion has the opportunity with a wide variety of catalysts to really start to demonstrate the potential of our philosophy for drug discovery. On the pipeline side, we've got multiple Phase 2 trial starts in 2024, multiple Phase 2 readouts over the next 18 months on roughly a quarterly cadence. And our hope is that if our pipeline continues to operate, we'll be able to meet or exceed that cadence in the future got multiple INDs that we think are going to happen in the near term... ...On the partnership side, we continue to move forward with our colleagues at Roche Genentech on a really pioneering visionary collaboration and so excited to be working with both the G-red and P-red teams. We've got the potential for near-term program and map options on top of the program option we already announced in oncology last fall with our ongoing collaboration with Bayer, we see significant opportunity in the near term in the space of undruggable oncology targets for some program options. We've got a fantastic collaboration with Tempus, and we've already identified some pretty exciting targets in the context of non-small cell lung cancer and we're starting to integrate larger chunks of their data for broader kind of pan-cancer causal AI models that are giving us really exciting hypotheses in oncology, And then as we've shared, we see the opportunity for additional transformational partnerships in the context of non-oncology areas, areas perhaps like cardiovascular and metabolism. And so we'll be looking forward, we hope, to being able to share more details there in the near future... ...Finally, as you saw as we shared our Phenom-Beta foundation model for image-based drug discovery with NVIDIA on BioNeMo. We continue to do business experiments with our data, using it as a value driver and have the potential to put some of our data, some of our tools into a variety of different marketplaces, a variety of different partnerships and we hope to be able to share more there soon. And then finally, our platform we're moving the Recursion OS from automated discovery, which is where I would argue we are today. Increasingly, workflows and processes that are being driven in an automated way towards autonomous discovery and our low platform that we unveiled at JPMorgan is a stepping stone in this direction towards autonomous discovery, where AI agents will be leveraging the tools that we built at Recursion, both wet lab and dry lab to automatically hypothesize about biology, automatically look for high areas of unmet need and automatically prioritize experimentation to give us the fastest route to impact for patients. We feel like that's where the industry is going to move, and we want to make sure we're leading that... ...I also want to share some of the things that I feel like are on our roadmap in the near term. Active learning I've talked about, proteomics I've talked about, but we're also doing a lot of exploration around the potential for organoids and steroids to help us increase both translation and kind of predictive ADME Tox at scale at Recursion. Those are kind of bottlenecks that we're working on now. On the automated synthesis side, we continue to think that the time that it takes to synthesize small molecules, 8 to 12 weeks is we've been bringing that down through our collaboration with Enamine, but we see a real opportunity to continue to accelerate that through things like automated synthesis and automated microsynthesis. And finally, we're ending Q1 with nearly $300 million in cash at the end of Q1. And I think that gives us robust runway and Recursion really feels poised with some of these milestones that I've just mentioned in the near term. These potential milestones giving us pretty significant runway extension as we begin to hit those. So we feel like we're in a really fantastic space, we're honored to be helping to lead the TechBio evolution as we move biotech into TechBio, and we're so thankful for all of your questions and support. And with that, I'm going to go ahead and move over to start answering some questions... ...Looks like we've got a question from Dante Noah, Eric Joseph on the team at JPM, Gil Bloom, etc., similar question here, and they're asking, what does success look like for each of your upcoming CCM, NF2, FAP, AXIN1, APC Phase 2 trial readouts and what might your next steps be. I think just given the time today, I won't go through each of these programs individually, but what I will share is for each of these programs, we are likely to be first in disease or near first in disease. When you have an opportunity like that, I think we really have to work with our colleagues at the agency, work with key opinion leaders, work with patient advocates to look at the sum of the evidence. Of course, we'll be looking for a therapeutic window, but we'll be looking for early signals of efficacy across a variety of different readouts in the context of CCM, for example, we could imagine looking for objective improvement in things like hemosiderin deposition around lesions as well as subjective improvements in things like patient-reported outcomes or other kind of neurologist reported outcome tools that we have in the secondary endpoints. As we look at the sum of the evidence for each of these, we'll work very closely with key opinion leaders and patients and the FDA. What we want to see is moving the biology. If we see that we're moving in the biology in a way that is going to be meaningful for patients potentially, that's going to be the signal we want to see to drive forward and have discussions with the agency. The next steps will be to aggressively pursue whatever it is, we can to move these medicines to patients. In some context, like NF2, it might be moving to start our Phase 3 trial in consultation with the agency. In other context, we might even have discussions with the agency about the potential for accelerated approval. But we're going to really need to see what the data looks like, and we'll be looking forward to reporting that in Q3 and Q4 in the first half of 2025 with more programs coming in the future... Moving on to another question here. Steve Dechert from KeyBank and Vikram Purohit from Morgan Stanley are asking, how should we think about the significance of your Phase 2 readout for REC-994, in terms of validating your platform and the potential for other programs in your pipeline? This is a great question and one we get asked pretty frequently. So Steve, Vikram, what I can say is, I think we've already got a lot of leading indicators of the power of this platform. As I've shared before, you can go back and look at the paper that we published a preprint in April of 2020, where now we are 9 for 10 at predicting the outcome of FDA-approved drug in the context of the SARS-CoV-2 virus, and we made all of those predictions well ahead of time. But as we all know, there's a lot that goes into every clinical trial, a lot of resources and trial design that can really influence the outcome and the probability of success of the average Phase 2 is somewhere between 25% and 35%. And so we know that there will, we hope, be both successes and we know there may be some failures. Ultimately, I think there's an uncorrelated opportunity with each of the programs we have moving forward. By that, I mean technically uncorrelated. Because even though we're using the same platform to identify each potential opportunity, we are validating those opportunities against the same gold standard animal models, pediatric oncology models, etc., that anyone else in the industry would use. While we certainly think a positive trial gives people a lot of optimism around what we're building, if any of these trials are negative, then we certainly could imagine that the technical risk is relatively uncorrelated between each of these. That's why we're pushing so hard to advance a whole pipeline of programs with readouts coming on a quarterly cadence. What's more, we've got programs that are now moving forward with pharma partners. We've got the potential for additional programs to move forward. We've got the potential for driving value through our data and through our computational and software opportunities. Recursion, unlike a traditional biopharma company really doesn't have the same bimodal risk that many other companies in this space do, who will typically advance one or two drugs to this big sort of Phase 2 readout... ...Great. Thanks for that question. Next, I'm going to go to Mary S and Gil. What success have you had to date with using the Tempus data? What other population genomics data might you look to access? How could such data complement what you were able to learn from Tempus? Great question. So we've already leveraged the Tempus data, signed that collaboration in either late November, early December of last year, had data coming in within weeks. The team worked over the holidays, and we had deployed some of our early AI models onto Tempus data in the first, really by the start of J.P. Morgan in the first couple of weeks of January. We've continued to refine that work, and as I shared earlier, we've already identified an exciting novel opportunity in the context of non-small cell lung cancer. We have a program that's now moving forward using the Tempus data, and I think we're really uniquely positioned to take the Tempus data alongside the proprietary data we've generated at Recursion to bring those together to identify targets that, really, you wouldn't be able to identify without these complementary data sets. So, you'll see us continue to move programs forward that way, and we hope, as those programs hit kind of the preclinical stage, we'll be able to share more about them. But as we just announced today in our collaboration with Helix, we're also now looking at sort of non-oncology scaled population genomics transcriptomics data. We think that's a really fascinating opportunity, not only for the same play, can we take that data looking across large non-oncology diseases, maybe in neuroscience, maybe in cardiovascular metabolism, combine it with our internal data to identify sort of this combination of forward and reverse genetics that can move the company forward, probably in some of our partnerships, either existing or future partnerships. But also, I would say, I think there's some opportunity in oncology and non-oncology space to actually use both the Tempus and the Helix data, along with our underlying data, to get a sense of how these genetic, these gene networks really work. Knowing how they're perturbed in the context of oncology settings, and how they're perturbed in the context of non-oncology settings, I think will give us a really robust field from which to work, robust substrate... It takes a while to take a discovery program and get it into the preclinical space, but rest assured, Mary and Gil, as we get those programs into IND-enabling studies, we look forward to being able to share quite a bit more. All right. Next, we're going to go to Laura, who asks about our London office. What are we looking for in the London office? Why are we opening a London office, and what are our international growth plans beyond that? Great question, Laura. We like to operate in cities and communities where we feel like there's an arbitrage, where there's great talent, and maybe fewer companies that are leveraging that talent. We're based in Salt Lake City. We've got fantastic teams, really focused in software engineering in Toronto, and other related areas, digital chemistry as well. We've got a great team in AI and AI research in Montreal. We've got a fantastic team in San Jose, Milpitas, with our InVivo facility. London felt like an opportunity for us to accelerate our computational biology talent. We think the UK has done a really tremendous job of training folks at the intersection of data science and computation with biology and chemistry, really probably ahead of the universities in the U.S. in terms of that integrated training. We had nearly 300 applicants in just the first couple of days when we announced our London office for just a couple of dozen positions that we posted, and these were extraordinarily talented folks. We feel like that bet is already paying off with fantastic talent in London... ...As far as other international plans, you know, I think that office is probably going to be a fantastic step for us internationally. We're still only a team of 530 or 540 folks, so I don't think you'll see us do a lot of additional international growth in the near term. But certainly as the company begins to move into development, begins to scale our development ambitions, maybe even thinks about commercialization in the intermediate to long term, we'll have an opportunity to grow in places like Asia, Western Europe, and beyond. So, I think those are more intermediate to long-term plans. Thanks, Laura. All right. Next up, we've got a question from Lucille M., who asks, what do you think about Xaira being founded, and how much are they a competitor for Recursion? Great question. ...So, for those who don't know, there's an exciting new tech bio company with a great cast of characters that got announced a couple weeks ago. They've got significant funding, really, you know, Marc Tessier-Lavigne and others who are leading that organization. There's a lot of diseases that need to be treated and need to be cured. So we welcome everybody to the space. Our belief is that the biopharma industry in a decade is going to look a lot more like scaled versions of companies like Recursion than it does today. So we welcome companies like Xaira to the space. We look forward to potentially collaborating with those companies and competing with those companies. What I can say is that we believe in tech bio. The primary bottleneck will be data. We're seeing that where data exists, companies are making extraordinarily rapid progress with computational tools like machine learning and AI. Where data is sparse, it's much, much more difficult. What we think Xaira will have to do is generate and aggregate high-quality datasets to make progress there. The reality is that cells take time to grow, organoids take time to grow... ...We know that they've got an incredible team, and we look forward to seeing how they start to work in that space, continue to work to build the right datasets. Certainly, from our perspective, the more the merrier. We look forward to leading the space, and we're so glad to see so many super competent companies joining us and others as we move towards what we see as an inevitable future. I think I'm going to do two more here. We've got a question from Hamida Alghazwi, who says, my daughter has Batten disease, CLN6, an ultra-rare genetic disease. Is Recursion willing to help labs who are interested in helping these kids, since we all know that pharmaceutical companies would not work for 35 patients? How to establish that kind of relationship? Thanks, Hamida, for the question. My heart goes out to you, your daughter, your family, everybody else with Batten disease, and everybody else with a rare disease. I think Recursion believes that by building maps of biology, by decoding biology, there will be a path forward to working across many of these diseases. We have a track record of working with patient groups. You can reach out to us via partnering at recursion.com and get connected to our patient advocacy team. There are scenarios where we have used our maps to work directly with patient advocates to try and advance programs forward... ...Ultimately, we do believe that companies like Recursion and others, as tech bio comes into the space, even if we don't have a clear hypothesis today around CLN6, and I don't know, I don't have the map pulled up right now, but even if we don't have a clear hypothesis around CLN6 today or other areas of Batten disease, these kinds of approaches, these scaled approaches, are going to be really, really exciting in the medium to long term. I know that's no consolation to you and your daughter today, but my hope is that in 5 to 10 years it's not going to be hard to see a biopharma company working across diseases that have 35 patients or maybe even less. Thank you so much for your question. And again, reach out to partnering at recursion.com. All right. Finally, we've got a final question here. There's a question about my beard, which I'm going to not answer and I will move on to a question from Amir Shahin, who asked, what's on the wish list, the next big pieces of the puzzle that we need to get put in place in the wider community over a five-year horizon and a 15-year horizon in order for us to progress as fast as possible and using state-of-the-art computation for drug discovery. Amir, I think it really comes down to the datasets. We believe that, ultimately, to fully understand biology, people are going to need to build out really deep, broad datasets... ...And you're not going to need to build out the 100s of these; you're going to need to build out a dozen or two dozen technologies, maybe its Phenomics, Proteomics, Metabolomics, Lipidomics, Transcriptomics, Euvolemic, add some scale, alongside Predictive ADME datasets, Tox Datasets, alongside Automated Synthesis and on the large molecule side moving in the direction of other modalities, RNAi therapies, Antibody Therapies, other kind of Gene Therapies. I think there will be a dozen or two dozen scaled technologies. The company who can bring together the highest number of those over the next five to 10 years in a disciplined and robust way is going to start to be able to pull out compounding efficiencies. So that even if you only make each step of drug discovery and development 5%, 20% better than it was before and you start layering these technologies together as I think Recursion is really doing the most better than any other TechBio startup in the space. You are going to start pulling together these compounding efficiencies, and that's going to create this flywheel of momentum and opportunity. Of course, we've got programs that are going to be reading out from our first-generation platform in the coming quarters. We're excited then for our second-generation molecule to start reading out after that, and we hope a third, a fourth, a fifth generation. At each stage will be able to demonstrate higher scale, lower cost, more rapid translation of these programs and ultimately, the biggest lever will be probability of success. As you all know, 90% of drugs fail in the clinics today from start to getting to the market. If we can get as an industry to 80% failure and then 70% failure and then 60% failure we're going to dramatically improve the access to medicines and dramatically reduce the price of medicines over the coming decades... ...We want to make sure that we are doing an experiment to ask and answer the kinds of tools that we're building can help lead out with that kind of vision. So watch for us to continue to build the vertical with small molecules and then as we make a lot of progress in that space, we can start to demonstrate successes in that space. You can see Recursion thinking about moving into complementary modalities as well so we can go after a broader range of diseases, both with our internal pipeline and with our biopharma partners. All right. Thanks, everybody. It's been fantastic to connect with you all for these 35 minutes here at our Q1 2024 earnings. Please follow us on social. Please post questions at our future learnings calls. Please engage with us at conferences and in other ways, we're so excited to be having this conversation with all of you and to be leading the TechBio field as we move Biotech into TechBio. Thanks, everybody. And have a fantastic evening. Bye-bye.