TWO SIGMA INVESTMENTS, LP

CIK

1179392

City

NEW YORK

State / Country

Stock

SDGR — Schrodinger, Inc.

Top Portfolio Positions

3,307 positions · $112,062,244,503 total · as of Mar 31, 2026

Ticker	Company	Shares	Value (USD)	% of Portfolio
NVDA	Nvidia Corp Technology	12,053,545	$2,102,138,248	1.88%
AAPL	Apple Inc. Technology	6,085,143	$1,544,348,441	1.38%
GOOGL	Alphabet Inc. Communication Services	4,810,528	$1,383,315,431	1.23%
AMZN	Amazon Com Inc Consumer Cyclical	6,454,567	$1,344,292,669	1.20%
TSLA	Tesla, Inc. Consumer Cyclical	3,116,099	$1,158,409,803	1.03%
JPM	Jpmorgan Chase & Co Financial Services	3,523,588	$1,036,498,646	0.92%
PLTR	Palantir Technologies Inc. Technology	6,809,802	$996,137,836	0.89%
COST	Costco Wholesale Corp /New Consumer Defensive	891,093	$887,911,797	0.79%
TJX	Tjx Companies Inc /De/ Consumer Cyclical	5,277,968	$842,891,489	0.75%
MA	Mastercard Inc Financial Services	1,682,998	$840,926,780	0.75%

25 quarters · across all stocks

26 quarters on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$1,771,024	155,900	-64.3%	Shares	Sole	2026-05-15
2025-12-31	$7,809,840	436,792	-44.8%	Shares	Sole	2026-02-17
2025-09-30	$15,868,743	791,064	-3.7%	Shares	Sole	2025-11-14
2025-06-30	$16,521,558	821,151	+238.7%	Shares	Sole	2025-08-14
2025-03-31	$4,785,449	242,424	+141.2%	Shares	Sole	2025-05-15
2024-12-31	$1,938,529	100,494	+412.7%	Shares	Sole	2025-02-14
2024-03-31	$529,200	19,600	-9.3%	Shares	Sole	2024-05-15
2023-12-31	$773,280	21,600	0.0%	Shares	Sole	2024-02-14
2023-09-30	$610,632	21,600	0.0%	Shares	Sole	2023-11-14
2023-06-30	$1,078,272	21,600	-8.5%	Shares	Sole	2023-08-14
2023-03-31	$621,388	23,600	-87.4%	Shares	Sole	2023-05-15
2022-12-31	$3,490,002	186,731	-38.3%	Shares	Sole	2023-02-14
2022-09-30	$7,554,351	302,416	+27.7%	Shares	Sole	2022-11-14
2022-06-30	$6,255,076	236,845	-26.1%	Shares	Sole	2022-08-15
2022-03-31	$10,935,289	320,495	+1235.4%	Shares	Sole	2022-05-16
2021-12-31	$835,920	24,000	-6.6%	Call	Sole	2022-02-14
2021-12-31	$895,131	25,700	-95.3%	Put	Sole	2022-02-14
2021-12-31	$19,095,059	548,236	+5382.4%	Shares	Sole	2022-02-14
2021-09-30	$546,800	10,000	-94.1%	Put	Sole	2021-11-15
2021-09-30	$9,209,479	168,425	+1103.0%	Shares	Sole	2021-11-15
2021-09-30	$765,520	14,000	+366.7%	Call	Sole	2021-11-15
2021-06-30	$226,830	3,000	0.0%	Call	Sole	2021-08-16
2021-06-30	$226,830	3,000	-88.3%	Put	Sole	2021-08-16
2021-06-30	$1,940,908	25,670	-92.2%	Shares	Sole	2021-08-16
2020-09-30	$15,723,767	330,957	+6519.1%	Shares	Sole	2020-11-16
2020-09-30	$237,550	5,000	—	Put	Sole	2020-11-16
No 13F history on record for this holder in this stock.