TWO SIGMA INVESTMENTS, LP

CIK

1179392

City

NEW YORK

State / Country

Stock

SGMO — Sangamo Therapeutics, Inc

Top Portfolio Positions

3,261 positions · $110,992,865,282 total · as of Mar 31, 2026

Ticker	Company	Shares	Value (USD)	% of Portfolio
NVDA	Nvidia Corp Technology	12,053,545	$2,102,138,248	1.89%
AAPL	Apple Inc. Technology	6,085,143	$1,544,348,441	1.39%
GOOGL	Alphabet Inc. Communication Services	4,810,528	$1,383,315,431	1.25%
AMZN	Amazon Com Inc Consumer Cyclical	6,454,567	$1,344,292,669	1.21%
TSLA	Tesla, Inc. Consumer Cyclical	3,116,099	$1,158,409,803	1.04%
JPM	Jpmorgan Chase & Co Financial Services	3,523,588	$1,036,498,646	0.93%
PLTR	Palantir Technologies Inc. Technology	6,809,802	$996,137,836	0.90%
COST	Costco Wholesale Corp /New Consumer Defensive	891,093	$887,911,797	0.80%
TJX	Tjx Companies Inc /De/ Consumer Cyclical	5,277,968	$842,891,489	0.76%
MA	Mastercard Inc Financial Services	1,682,998	$840,926,780	0.76%

43 quarters · across all stocks

Compact Export CSV

25 quarters on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$1,567,610	6,270,441	+31.8%	Shares	Sole	2026-05-15
2025-12-31	$1,997,517	4,755,995	+91.8%	Shares	Sole	2026-02-17
2025-09-30	$1,661,054	2,479,186	+182.7%	Shares	Sole	2025-11-14
2025-06-30	$473,622	877,079	+11.5%	Shares	Sole	2025-08-14
2025-03-31	$519,251	786,745	-22.3%	Shares	Sole	2025-05-15
2024-12-31	$1,032,892	1,012,640	+222.1%	Shares	Sole	2025-02-14
2024-09-30	$273,479	314,344	-42.1%	Shares	Sole	2024-11-14
2024-06-30	$195,549	543,194	-2.1%	Shares	Sole	2024-08-14
2024-03-31	$371,752	554,855	-74.5%	Shares	Sole	2024-05-15
2023-12-31	$1,174,031	2,174,133	+142.5%	Shares	Sole	2024-02-14
2023-09-30	$537,856	896,427	-27.5%	Shares	Sole	2023-11-14
2023-06-30	$1,608,384	1,237,219	+33.0%	Shares	Sole	2023-08-14
2023-03-31	$1,637,667	930,493	-14.3%	Shares	Sole	2023-05-15
2022-12-31	$3,409,898	1,085,955	-7.3%	Shares	Sole	2023-02-14
2022-09-30	$5,737,782	1,170,976	+60.7%	Shares	Sole	2022-11-14
2022-06-30	$3,017,356	728,830	+102.2%	Shares	Sole	2022-08-15
2022-03-31	$2,093,877	360,392	-25.6%	Shares	Sole	2022-05-16
2021-12-31	$3,632,550	484,340	+10.6%	Shares	Sole	2022-02-14
2021-09-30	$3,947,199	438,091	-18.4%	Shares	Sole	2021-11-15
2021-06-30	$6,426,070	536,848	-41.5%	Shares	Sole	2021-08-16
2021-03-31	$11,499,181	917,732	-26.8%	Shares	Sole	2021-05-17
2020-12-31	$19,577,172	1,254,143	-29.5%	Shares	Sole	2021-02-16
2020-09-30	$16,814,479	1,779,310	-16.3%	Shares	Sole	2020-11-16
2020-06-30	$19,044,793	2,125,535	+124.3%	Shares	Sole	2020-08-14
2020-03-31	$6,037,511	947,804	—	Shares	Sole	2020-05-15
No 13F history on record for this holder in this stock.