TWO SIGMA ADVISERS, LP

CIK

1478735

City

NEW YORK

State / Country

NY

Stock

TBPH — Theravance Biopharma, Inc.

Top Portfolio Positions

2,276 positions · $51,226,514,524 total · as of Dec 31, 2025

Ticker	Company	Shares	Value (USD)	% of Portfolio	Open
NVDA	Nvidia Corp Technology	8,951,900	$1,669,529,350	3.26%
AAPL	Apple Inc. Technology	5,896,700	$1,603,076,862	3.13%
MSFT	Microsoft Corp Technology	2,673,180	$1,292,803,311	2.52%
AMZN	Amazon Com Inc Consumer Cyclical	4,979,120	$1,149,280,478	2.24%
JPM	Jpmorgan Chase & Co Financial Services	2,204,020	$710,179,324	1.39%
MA	Mastercard Inc Financial Services	1,227,980	$701,029,222	1.37%
MU	Micron Technology Inc Technology	2,331,800	$665,519,038	1.30%
PLTR	Palantir Technologies Inc. Technology	3,674,200	$653,089,050	1.27%
SCHW	Schwab Charles Corp Financial Services	6,283,895	$627,823,949	1.23%
TSLA	Tesla, Inc. Consumer Cyclical	1,389,973	$625,098,657	1.22%

Portfolio Trend

24 quarters · across all stocks

Holdings in TBPH

Compact Export CSV

Shares Held

Position Value (USD)

14 quarters on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2025-12-31	$7,100,445	379,500	+89.5%	Shares	Sole	2026-02-17
2025-09-30	$2,924,380	200,300	+588.3%	Shares	Sole	2025-11-14
2025-06-30	$320,973	29,100	+17.8%	Shares	Sole	2025-08-14
2025-03-31	$220,571	24,700	-27.1%	Shares	Sole	2025-05-15
2024-06-30	$287,472	33,900	-64.1%	Shares	Sole	2024-08-14
2023-06-30	$976,005	94,300	-80.5%	Shares	Sole	2023-08-14
2023-03-31	$5,249,230	483,800	-52.0%	Shares	Sole	2023-05-15
2022-12-31	$11,316,492	1,008,600	+44.8%	Shares	Sole	2023-02-14
2022-09-30	$7,063,524	696,600	+6410.3%	Shares	Sole	2022-11-14
2022-03-31	$102,292	10,700	-64.1%	Shares	Sole	2022-05-16
2021-03-31	$608,218	29,800	-19.5%	Shares	Sole	2021-05-17
2020-12-31	$657,490	37,000	-53.6%	Shares	Sole	2021-02-16
2020-09-30	$1,179,843	79,800	+55.3%	Shares	Sole	2020-11-16
2020-06-30	$1,078,886	51,400	—	Shares	Sole	2020-09-15
No 13F history on record for this holder in this stock.