TWO SIGMA ADVISERS, LP

CIK

1478735

City

NEW YORK

State / Country

Stock

VNDA — Vanda Pharmaceuticals Inc.

Top Portfolio Positions

2,281 positions · $51,380,076,629 total · as of Dec 31, 2025

Ticker	Company	Shares	Value (USD)	% of Portfolio
NVDA	Nvidia Corp Technology	8,951,900	$1,669,529,350	3.25%
AAPL	Apple Inc. Technology	5,896,700	$1,603,076,862	3.12%
MSFT	Microsoft Corp Technology	2,673,180	$1,292,803,311	2.52%
AMZN	Amazon Com Inc Consumer Cyclical	4,979,120	$1,149,280,478	2.24%
JPM	Jpmorgan Chase & Co Financial Services	2,204,020	$710,179,324	1.38%
MA	Mastercard Inc Financial Services	1,227,980	$701,029,222	1.36%
MU	Micron Technology Inc Technology	2,331,800	$665,519,038	1.30%
PLTR	Palantir Technologies Inc. Technology	3,674,200	$653,089,050	1.27%
SCHW	Schwab Charles Corp Financial Services	6,283,895	$627,823,949	1.22%
TSLA	Tesla, Inc. Consumer Cyclical	1,389,973	$625,098,657	1.22%

24 quarters · across all stocks

24 quarters on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2025-12-31	$9,254,826	1,049,300	+15.4%	Shares	Sole	2026-02-17
2025-09-30	$4,537,407	909,300	+12.4%	Shares	Sole	2025-11-14
2025-06-30	$3,819,424	809,200	+244.0%	Shares	Sole	2025-08-14
2025-03-31	$1,079,568	235,200	+50.5%	Shares	Sole	2025-05-15
2024-12-31	$748,677	156,300	+11.2%	Shares	Sole	2025-02-14
2024-09-30	$659,414	140,600	-34.3%	Shares	Sole	2024-11-14
2024-06-30	$1,209,665	214,100	-69.6%	Shares	Sole	2024-08-14
2024-03-31	$2,893,029	703,900	-20.6%	Shares	Sole	2024-05-15
2023-12-31	$3,741,030	886,500	+15.4%	Shares	Sole	2024-02-14
2023-09-30	$3,319,056	768,300	+22.8%	Shares	Sole	2023-11-14
2023-06-30	$4,123,363	625,700	+8.4%	Shares	Sole	2023-08-14
2023-03-31	$3,920,546	577,400	+27.3%	Shares	Sole	2023-05-15
2022-12-31	$3,350,626	453,400	+3.6%	Shares	Sole	2023-02-14
2022-09-30	$4,325,464	437,800	-25.3%	Shares	Sole	2022-11-14
2022-06-30	$6,384,130	585,700	-0.1%	Shares	Sole	2022-08-15
2022-03-31	$6,627,660	586,000	+7.1%	Shares	Sole	2022-05-16
2021-12-31	$8,588,706	547,400	+41.0%	Shares	Sole	2022-02-14
2021-09-30	$6,655,462	388,300	-5.1%	Shares	Sole	2021-11-15
2021-06-30	$8,799,741	409,100	+25.8%	Shares	Sole	2021-08-16
2021-03-31	$4,886,006	325,300	+20.7%	Shares	Sole	2021-05-17
2020-12-31	$3,542,544	269,600	-13.5%	Shares	Sole	2021-02-16
2020-09-30	$3,011,988	311,800	-29.4%	Shares	Sole	2020-11-16
2020-06-30	$5,051,904	441,600	+5.8%	Shares	Sole	2020-09-15
2020-03-31	$4,322,192	417,200	—	Shares	Sole	2020-05-15
No 13F history on record for this holder in this stock.