DERM

On July 1, 2026, the reporting person was granted 50,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 16,666 shares on July 1, 2029, 16,667 shares on July 1, 2030 and 16,667 shares on July 1, 2031.

Includes restricted stock units, which vest over various time periods.

On July 1, 2026, the reporting person was granted 50,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 16,666 shares on July 1, 2029, 16,667 shares on July 1, 2030 and 16,667 shares on July 1, 2031.

Includes restricted stock units, which vest over various time periods.

On July 1, 2026, the reporting person was granted 50,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 16,666 shares on July 1, 2029, 16,667 shares on July 1, 2030 and 16,667 shares on July 1, 2031.

Includes restricted stock units, which vest over various time periods.

On June 25, 2026, the reporting person was granted 10,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 10,000 shares on June 25, 2027.

Includes restricted stock units, which vest over various time periods.

On June 25, 2026, the reporting person was granted 10,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 10,000 shares on June 25, 2027.

Includes restricted stock units, which vest over various time periods.

On June 25, 2026, the reporting person was granted 10,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 10,000 shares on June 25, 2027.

Includes restricted stock units, which vest over various time periods.

On June 25, 2026, the reporting person was granted 10,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 10,000 shares on June 25, 2027.

Includes restricted stock units, which vest over various time periods.

On June 25, 2026, the reporting person was granted 10,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 10,000 shares on June 25, 2027.

Includes restricted stock units, which vest over various time periods.

On April 22, 2026, the reporting person was granted 49,277 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 16,426 shares on April 22, 2027, 16,426 shares on April 22, 2028 and 16,425 shares on April 22, 2029.

Includes restricted stock units, which vest over various time periods.

On April 22, 2026, the reporting person was granted 46,863 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 15,621 shares on April 22, 2027, 15,621 shares on April 22, 2028 and 15,621 shares on April 22, 2029.

Includes restricted stock units, which vest over various time periods.

On April 22, 2026, the reporting person was granted 28,907 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 9,636 shares on April 22, 2027, 9,636 shares on April 22, 2028 and 9,635 shares on April 22, 2029.

Includes restricted stock units, which vest over various time periods.

On April 22, 2026, the reporting person was granted 82,915 stock options pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 27,638 shares on April 22, 2027, 27,638 shares on April 22, 2028 and 27,639 shares on April 22, 2029.

On April 22, 2026, the reporting person was granted 41,860 stock options pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 13,953 shares on April 22, 2027, 13,953 shares on April 22, 2028 and 13,954 shares on April 22, 2029.

On April 22, 2026, the reporting person was granted 62,795 stock options pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 20,932 shares on April 22, 2027, 20,932 shares on April 22, 2028 and 20,931 shares on April 22, 2029.

Due to administrative error, the number of non-derivative securities beneficially owned by the reporting person was incorrectly reported as 2,397,590 instead of 1,147,590 on a Form 4 filed on June 20, 2025. This column reflects the corrected balance, as effected by the transactions reported on this Form 4.

On October 19, 2015, the reporting person was granted 1,250,000 stock options pursuant to the Issuer's 2015 Stock Plan, as amended, that vested in accordance with the following schedule: 412,500 shares on January 7, 2016, 250,000 shares on September 22, 2016, 337,500 shares on January 7, 2017 and 250,000 shares on September 22, 2017. The 1,250,000 stock options are due to expire on October 19, 2025. Accordingly, the reporting person is exercising the stock options within the 60 days prior to the expiration date.

On August 5, 2025, the reporting person was granted 20,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 6,667 shares on August 5, 2028, 6,667 shares on August 5, 2029 and 6,666 shares on August 5, 2030.

Includes restricted stock units, which vest over various time periods.

On August 5, 2025, the reporting person was granted 20,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 6,667 shares on August 5, 2028, 6,667 shares on August 5, 2029 and 6,666 shares on August 5, 2030.

Includes restricted stock units, which vest over various time periods.

On August 5, 2025, the reporting person was granted 50,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 16,667 shares on August 5, 2028, 16,667 shares on August 5, 2029 and 16,666 shares on August 5, 2030.

Includes restricted stock units, which vest over various time periods.

On August 5, 2025, the reporting person was granted 20,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 6,667 shares on August 5, 2028, 6,667 shares on August 5, 2029 and 6,666 shares on August 5, 2030.

Includes restricted stock units, which vest over various time periods.

On August 5, 2025, the reporting person was granted 20,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in accordance with the following schedule: 6,667 shares on August 5, 2028, 6,667 shares on August 5, 2029 and 6,666 shares on August 5, 2030.

Includes restricted stock units, which vest over various time periods.

On June 25, 2025, the reporting person was granted 7,173 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in full on June 25, 2026.

Includes restricted stock units, which vest over various time periods.

On June 25, 2025, the reporting person was granted 7,173 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in full on June 25, 2026.

Includes restricted stock units, which vest over various time periods.

On June 25, 2025, the reporting person was granted 7,173 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in full on June 25, 2026.

Includes restricted stock units, which vest over various time periods.

On June 25, 2025, the reporting person was granted 7,173 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in full on June 25, 2026.

Includes restricted stock units, which vest over various time periods.

On June 25, 2025, the reporting person was granted 7,173 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, which will vest in full on June 25, 2026.

Includes restricted stock units, which vest over various time periods.

On June 17, 2025, the reporting person was granted 49,277 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 16,426 shares on January 1, 2026, 16,426 shares on January 1, 2027 and 16,425 shares on January 1, 2028.

Includes restricted stock units, which vest over various time periods.

On June 17, 2025, the reporting person was granted 82,915 stock options pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 27,638 shares on January 1, 2026, 27,638 shares on January 1, 2027 and 27,639 shares on January 1, 2028.

On June 17, 2025, the reporting person was granted 41,860 stock options pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 13,953 shares on January 1, 2026, 13,953 shares on January 1, 2027 and 13,954 shares on January 1, 2028.

On June 17, 2025, the reporting person was granted 28,907 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 9,636 shares on January 1, 2026, 9,636 shares on January 1, 2027 and 9,635 shares on January 1, 2028.

Includes restricted stock units, which vest over various time periods.

On June 17, 2025, the reporting person was granted 46,863 restricted stock units pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 15,621 shares on January 1, 2026, 15,621 shares on January 1, 2027 and 15,621 shares on January 1, 2028.

Includes restricted stock units, which vest over various time periods.

On June 17, 2025, the reporting person was granted 62,795 stock options pursuant to the Issuer's 2015 Stock Plan, as amended, that will vest in accordance with the following schedule: 20,932 shares on January 1, 2026, 20,932 shares on January 1, 2027 and 20,931 shares on January 1, 2028.

In connection with the vesting of restricted stock units which vested as of various dates, a total of 2,857 of the underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on May 2, 2025, was $6.73 to $7.05. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

In connection with the vesting of restricted stock units which vested as of various dates, a total of 4,834 of the underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on May 2, 2025, was $6.73 to $7.05. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

In connection with the vesting of restricted stock units which vested as of various dates, a total of 2,409 of the underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on May 2, 2025, was $6.73 to $7.05. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

In connection with the vesting of restricted stock units which vested as of various dates, a total of 49,271 of such underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on March 11, 2025, was $4.99 to $5.11. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

In connection with the vesting of restricted stock units which vested as of various dates, a total of 14,905 of such underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on March 7, 2025, was $4.99 to $5.14. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

In connection with the vesting of restricted stock units which vested as of various dates, a total of 25,551 of such underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on March 6, 2025, was $5.00 to $5.26. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

In connection with the vesting of restricted stock units which vested as of various dates, a total of 18,147 of such underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on March 5, 2025, was $5.02 to $5.26. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

In connection with the vesting of restricted stock units which vested as of various dates, a total of 28,901 of such underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on March 4, 2025, was $5.00 to $5.17. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

In connection with the vesting of restricted stock units which vested as of various dates, a total of 23,508 of such underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on March 3, 2025, was $5.00 to $5.57. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

In connection with the vesting of restricted stock units on February 20, 2025, a total of 1,365 of such underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on February 21, 2025, was $5.19 to $5.20. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

In connection with the vesting of restricted stock units on July 31, 2024, a total of 9,324 of such underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on August 1, 2024, was $5.45 to $5.55. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods

In connection with the vesting of restricted stock units on July 21, 2024, a total of 4,055 of such underlying shares were sold by the Issuer in order to satisfy the Reporting Person's tax withholding obligations. The Reporting Person had no discretion with respect to such sale, which was conducted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock units.

Reflects the weighted average sale price of multiple same-way open market sale transactions effected by the Reporting Person on the same day at different prices through a sale order executed by a broker-dealer. The Reporting Person reported on a single line all such transactions that occurred within a one-dollar price range. The range of prices for the sale transactions on July 23, 2024, was $5.40 to $5.43. The Reporting Person hereby undertakes to provide upon request by the Securities Exchange Commission staff, the Issuer, or a stockholder of the Issuer, full information regarding the number of shares sold at each separate price.

Includes restricted stock units, which vest over various time periods.

On July 19, 2024, the reporting person was granted 30,000 restricted stock units pursuant to the Issuer's 2015 Stock Plan, which will vest over a three-year period.

On July 8, 2024, the reporting person was granted 9,728 restricted stock units pursuant to the Issuer's 2015 Stock Plan, which will vest in full on July 8, 2025.

Includes restricted stock units, which vest over various time periods.

On July 8, 2024, the reporting person was granted 9,728 restricted stock units pursuant to the Issuer's 2015 Stock Plan, which will vest in full on July 8, 2025.

Includes restricted stock units, which vest over various time periods.

On July 8, 2024, the reporting person was granted 9,728 restricted stock units pursuant to the Issuer's 2015 Stock Plan, which will vest in full on July 8, 2025.

Includes restricted stock units, which vest over various time periods.