TWO SIGMA INVESTMENTS, LP

Position in DHR — Danaher Corp /De/

CIK 1179392 NEW YORK, NY

Back to DHR Full portfolio

Position in DHR

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$352,425,067

+$345,758,230 QoQ

Shares Held

1,858,782

+6282.5% QoQ

Ownership

0.263%

of shares outstanding

% of Portfolio

0.32%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2020

21 quarters on record

Voting authority Sole 99.11770180688214.ToString("F0")% Shared 0.ToString("F0")% None 0.882298193117859.ToString("F0")%

Common Shares in DHR Over Time

Shares Held

Position Value (USD)

Derivatives in DHR

reported options exposure · as of Dec 31, 2025

CallValue

$2,060,280

CallShares

9,000

PutValue

$1,236,168

PutShares

5,400

Notional value of option positions as reported on Form 13F. Calls and puts are disclosed separately and do not net against the common-share stake above.

Position in Diagnostics & Research

Healthcare · as of Mar 31, 2026

TWO SIGMA INVESTMENTS, LP holds $1,108,346,968 across 33 Diagnostics & Research names. DHR ranks #2 (31.8% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	GH	Guardant Health, Inc.	4,229,531	$390,681,778
2	DHR	Danaher Corp /De/ This page	1,858,782	$352,425,067
3	TMO	Thermo Fisher Scientific Inc.	187,893	$92,355,046
4	MEDP	Medpace Holdings, Inc.	176,557	$84,780,905
5	A	Agilent Technologies, Inc.	677,347	$77,204,011
6	IQV	Iqvia Holdings Inc.	219,984	$37,516,071
7	ILMN	Illumina, Inc.	73,717	$9,086,357
8	NTRA	Natera, Inc.	40,200	$8,039,598

All Filings in DHR

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36 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$352,425,067	1,858,782	+6282.5%	Shares	Sole	2026-05-15
2025-12-31	$6,666,837	29,123	+439.3%	Shares	Sole	2026-02-17
2025-12-31	$1,236,168	5,400	-40.0%	Put	Sole	2026-02-17
2025-12-31	$2,060,280	9,000	-99.1%	Call	Sole	2026-02-17
2025-09-30	$209,219,218	1,055,277	-11.3%	Shares	Sole	2025-11-14
2025-06-30	$235,009,189	1,189,679	+7.6%	Shares	Sole	2025-08-14
2025-03-31	$226,648,205	1,105,601	+7.6%	Shares	Sole	2025-05-15
2024-12-31	$235,861,477	1,027,495	+316.7%	Shares	Sole	2025-02-14
2024-09-30	$68,549,723	246,564	+273.0%	Shares	Sole	2024-11-14
2024-03-31	$16,506,741	66,101	-82.0%	Shares	Sole	2024-05-15
2023-06-30	$78,296,398	367,993	-64.2%	Shares	Sole	2023-08-14
2023-03-31	$229,517,036	1,027,199	+2172.6%	Shares	Sole	2023-05-15
2023-03-31	$10,099,474	45,200	-77.7%	Put	Sole	2023-05-15
2022-12-31	$47,744,771	202,909	+282.8%	Shares	Sole	2023-02-14
2022-12-31	$12,470,974	53,000	0.0%	Put	Sole	2023-02-14
2022-09-30	$12,135,966	53,000	-57.6%	Put	Sole	2022-11-14
2022-09-30	$28,601,267	124,907	+44.3%	Shares	Sole	2022-11-14
2022-06-30	$19,457,437	86,573	+63.3%	Shares	Sole	2022-08-15
2022-06-30	$11,911,845	53,000	+579.5%	Put	Sole	2022-08-15
2022-03-31	$2,028,345	7,800	-65.3%	Put	Sole	2022-05-16
2021-12-31	$6,562,698	22,500	-91.6%	Call	Sole	2022-02-14
2021-12-31	$78,095,531	267,748	+906.6%	Shares	Sole	2022-02-14
2021-12-31	$7,758,568	26,600	-95.6%	Put	Sole	2022-02-14
2021-09-30	$164,629,158	609,978	+7524.7%	Shares	Sole	2021-11-15
2021-09-30	$2,159,148	8,000	+14.3%	Call	Sole	2021-11-15
2021-09-30	$1,889,255	7,000	-37.5%	Put	Sole	2021-11-15
2021-03-31	$2,234,836	11,200	-26.8%	Call	Sole	2021-05-17
2021-03-31	$3,052,946	15,300	-87.4%	Put	Sole	2021-05-17
2021-03-31	$24,266,137	121,611	+12061.1%	Shares	Sole	2021-05-17
2020-12-31	$196,932	1,000	-99.6%	Call	Sole	2021-02-16
2020-12-31	$47,194,700	239,649	+4421.7%	Shares	Sole	2021-02-16
2020-12-31	$1,043,742	5,300	-99.4%	Put	Sole	2021-02-16
2020-09-30	$165,647,956	867,742	+3149.4%	Shares	Sole	2020-11-16
2020-06-30	$4,186,387	26,705	+1235.2%	Shares	Sole	2020-08-14
2020-03-31	$245,407	2,000	+17.6%	Call	Sole	2020-05-15
2020-03-31	$208,596	1,700	—	Put	Sole	2020-05-15
No filing history on record for this holder in this stock.