FMR LLC

CIK

0000315066

City

BOSTON

State / Country

Stock

IONS — IONIS PHARMACEUTICALS INC

Holdings in IONS

Position Over Time

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2025-12-31	$1,904,343,909	24,072,101	+1.6%	Shares	Defined	2026-02-17
2025-09-30	$1,549,736,864	23,689,038	+0.2%	Shares	Defined	2025-11-13
2025-06-30	$934,134,532	23,642,990	+0.1%	Shares	Defined	2025-08-14
2025-03-31	$712,421,857	23,613,585	+4.1%	Shares	Defined	2025-05-12
2024-12-31	$793,224,603	22,689,491	+0.9%	Shares	Defined	2025-02-13
2024-09-30	$900,529,929	22,479,529	+2.7%	Shares	Defined	2024-11-13
2024-06-30	$1,043,506,453	21,894,806	+0.1%	Shares	Defined	2024-08-13
2024-03-31	$947,749,561	21,862,735	+1.6%	Shares	Defined	2024-05-13
2023-12-31	$1,088,740,913	21,520,872	+0.1%	Shares	Defined	2024-02-13
2023-09-30	$975,191,101	21,498,922	+0.2%	Shares	Defined	2023-11-13
2023-06-30	$880,660,369	21,463,816	+0.1%	Shares	Defined	2023-08-11
2023-03-31	$766,134,577	21,436,334	+0.6%	Shares	Defined	2023-08-11
2022-12-31	$804,784,991	21,307,519	+0.1%	Shares	Defined	2023-02-13
2022-09-30	$941,707,962	21,291,159	+0.1%	Shares	Defined	2022-11-10
2022-06-30	$787,399,110	21,269,560	-0.2%	Shares	Defined	2022-08-12
2022-03-31	$789,725,616	21,320,886	+0.7%	Shares	Defined	2022-05-13
2021-12-31	$644,553,105	21,181,502	+0.0%	Shares	Defined	2022-02-14
2021-09-30	$710,114,044	21,172,154	+0.1%	Shares	Defined	2022-02-14
2021-06-30	$843,452,309	21,144,455	+0.2%	Shares	Defined	2021-08-13
2021-03-31	$948,381,564	21,093,896	+0.7%	Shares	Defined	2021-05-14
2020-12-31	$1,183,836,442	20,938,034	+0.3%	Shares	Defined	2021-02-08
2020-09-30	$990,136,872	20,866,952	+0.3%	Shares	Defined	2020-11-13
2020-06-30	$1,226,990,263	20,810,554	-0.7%	Shares	Defined	2020-08-24
2020-03-31	$990,999,532	20,960,227	—	Shares	Defined	2020-05-14