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IONS

Ionis Pharmaceuticals Inc
$58.25 -6.02 (-9.37%) At close · Jul 10
Market Cap
$9.63B
Shares
165,262,556

Price & Indicators

20d MA 50d MA 200d MA Earnings Filing Insider Congress Investor day
Close$58.25 Open$64.27 Day$58.20–64.44 52W$40.03–86.74 Avg vol 30d2.7M Short int17.4M · 10.5% float · 7.3d Short vol60% Last earningsApr 29, 2026 DataJan 2020–Jul 2026 Filing10-Q · Apr 29
Up next
Next earnings call
Jul 29, 2026 Est · unconfirmed · in 2 wks
FQ3-26 quarter ends
~Sep 30, 2026 Est
filed Apr 29, 2026
AI Brief

TL;DR.

Bullish
    Bearish

      AI-generated from the earnings call and 8-K · may contain errors · not investment advice

      Equibles Rating blended score · not investment advice
      Overall
      Sell
      SellHoldBuy
      Technical Sell Momentum Very Weak Sentiment Bullish Fundamentals Weak Quant / Vol Very High
      Market backdrop VIX 15 · calm Equity put/call 0.55
      Technical
      price trend
      Sell
      50 / 200-day cross No cross
      Price vs 200-day avg −23%
      below
      Price vs 50-day avg −23%
      below
      RSI (14) 26
      oversold
      MACD trend Negative
      52-week position 39%
      mid-range
      Volume (OBV) Confirms
      volume backs price
      Momentum
      relative strength
      Very Weak
      1-month return −21%
      trailing
      6-month return −25%
      trailing
      YTD return −26%
      this year
      Relative strength −34%
      vs S&P · 6-mo
      Sentiment
      smart money
      Bullish
      Trend (MA cross) No cross
      50d $76 › 200d $76 — 200d above 50d
      Institutional flow Accumulating
      19 of 496 funds reported for Jun 30 · net +177.8K sh shares · +4 new
      Insider flow Distributing
      Net -$8.9M over 90 days · 100% sells
      Short interest Falling
      10.54% of float · ▼ -1.9% MoM · 7.3 days cover
      Volume signal Reversal watch
      High volume on a down day — possible exhaustion
      Institution breadth Multi-yr high
      496 holders — near 3-yr high, broad support
      Squeeze score 70
      elevated · 0–100
      Fundamentals
      Weak
      Revenue growth −10%
      Y/Y
      EPS growth +22%
      Y/Y
      Free cash flow $-320.0M
      Buyback $125.0M
      authorized
      Balance sheet $1.4B
      net debt
      Quant / Vol
      risk profile
      Very High
      Volatility 53%
      annualized · 1-yr
      Max drawdown −33%
      past year
      ATR 6.8%
      of price · 14-day

      Blended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.

      Guidance & track record
      Latest guidance · from the 8-K filed Apr 29, 2026
      Full Year 2026
      Total Revenue Initiated $875M – $900M
      prior FY $943.71M midpoint −6.0% Y/Y
      Operating loss on a non-GAAP basis Non-GAAP Initiated $-475M – $-425M
      Cash, cash equivalents and short-term investments Initiated at least $1.6B
      peak
      Annual olezarsen peak net sales at least $3B

      Guidance from company 8-Ks · delivered figures from as-reported statements · no analyst estimates involved.

      Technicals

      trend & momentum for long-term holders Sell
      3 · 4 · 0
      50 / 200-day cross
      No cross Neutral
      Price vs 200-day avg
      −23% Bearish
      Price vs 50-day avg
      −23% Bearish
      RSI (14)
      26 Neutral
      MACD trend
      Negative Bearish
      52-week position
      39% Neutral
      Volume (OBV)
      Confirms Neutral
      Market signals — smart money & positioning
      Bullish · 3 of 6
      Trend (MA cross) No cross
      50d $76 › 200d $76 — 200d above 50d
      Institutional flow Accumulating
      19 of 496 funds reported for Jun 30 · net +177.8K sh shares · +4 new
      Insider flow Distributing
      Net -$8.9M over 90 days · 100% sells
      Short interest Falling
      10.54% of float · ▼ -1.9% MoM · 7.3 days cover
      Volume signal Reversal watch
      High volume on a down day — possible exhaustion
      Institution breadth Multi-yr high
      496 holders — near 3-yr high, broad support
      Price context
      position in its 52-week range
      52-wk low $40 Now $58 · 39% 52-wk high $87
      vs 200-day avg -23% vs 50-day avg -23%

      Illustrative technical + ownership context — a signal mix, not investment advice.

      Key metrics

      the company's own KPIs, from its earnings releases, calls, and filings
      Metric Latest Period YoY
      Cash and short-term investments $1.9B the first quarter ended March 31, 2026
      Operating expenses on a non-GAAP basis non-GAAP $321M Three months ended March 31
      DAWNZERA product sales $16M Q1 2026 call
      Tryngolza product sales $27M Q1 2026 call
      DAWNZERA net product sales $7M Q4 2025
      TRYNGOLZA net product sales $108M Year ended December 31, 2025

      Figures exactly as the company stated them · click a metric with a to chart its history · period links open the stating document · "call" marks figures stated on the earnings call, "filing" figures stated in the 10-K/10-Q · YoY needs the prior-year figure on file

      Versus peers

      Biotechnology — same industry group
      Open screener →
      Company Mkt cap YTD Rev growth Y/Y P/E Short % shares
      IONS
      Ionis Pharmaceuticals Inc
      this stock
      $9.63B -26.4% +32.5% 10.5%
      ONC
      BeOne Medicines Ltd.
      $431.70B -1.7% +22179.2% 878.5 0.1%
      VRTX
      Vertex Pharmaceuticals Inc / Ma
      $123.19B +7.1% +46.2% 28.8 1.9%
      REGN
      Regeneron Pharmaceuticals, Inc.
      $69.67B -13.8% +20.8% 16.2 3.3%
      ARGX
      Argenx SE
      $54.85B +4.4% 2.3%

      Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding

      At a glance

      key data from every section
      Ownership
      Institutional Holders Accumulating
      Holders
      499
      % held
      101.8%
      Reported
      19 of 496
      Top holder
      FMR LLC
      Held Float
      View
      Held by Funds
      Fund positions
      460
      View
      Short & Settlement
      Short Interest Falling
      Shares short
      17.4M
      Days to cover
      7.3d
      Change
      -332.3K sh
      View
      Short Volume
      Short vol %
      60%
      As of
      Jul 10, 2026
      Short Total
      View
      Fails to Deliver
      FTD shares
      7
      Value
      $517
      As of
      Jun 12, 2026
      View
      Off-Exchange
      Off-exchange %
      74.4%
      Week of
      Jun 15, 2026
      Off-exch Lit
      View
      Smart Money
      Insider Trades Net selling
      Net (90d)
      -$8.9M
      Buyers / Sellers
      0 / 8
      Buyers Sellers
      View
      Congressional Trades Sell
      Member
      Daniel Goldman
      Amount
      $1.0K–$15.0K
      Traded
      Mar 6, 2023
      View
      Financials
      Financials
      Revenue (FY)
      $203.3M
      Net income (FY)
      $-381.4M
      EPS diluted
      $-2.38
      View
      Buybacks
      Authorized
      $125.0M
      View
      Filings
      SEC Filings
      Latest
      8-K
      Filed
      Jul 10, 2026
      This year
      16
      View
      Proposed Sales
      Value
      $863.6K
      Shares
      10.1K
      Filed
      Jul 7, 2026
      View
      Earnings & Events
      Earnings Calls
      Last call
      Jun 10, 2026
      View

      Performance

      5D 20D 120D MTD YTD
      IONS -28.8% -20.6% -24.6% -26.5% -26.4%
      SPY +1.4% +4.1% +9.1% +1.1% +10.7%
      vs SPY -30.2% -24.6% -33.6% -27.6% -37.1%

      Capital returns

      Buyback program · as of Sep 30, 2019
      Authorized
      $125.00M
      Spent (derived)
      Remaining

      Dividends per share over the trailing 365 days by ex-date · buyback figures as last reported in SEC filings ("spent" derived as authorized − remaining; when several programs run concurrently, authorized is their combined total per the newest filing) · components shown separately — trailing-year buyback spend isn't tracked, so no combined shareholder yield is derived.

      Key facts CIK 874015 CUSIP 462222100 13F (30d) 42 filings 22 filers Visit website Investor relations