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Ionis Pharmaceuticals Inc
$54.73 -0.20 (-0.36%) At close · Jul 15
Market Cap
$9.04B
Shares
165,262,556

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

The Jun 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out.
Holders: 500
Total Value: $12,650,366,996
Total Shares: 168,415,772
Showing 1–100 of 527 holdings by value · page 1 of 6

Institutional Ownership Trend

26 quarters

Superinvestors Holding IONS

All superinvestors →
Tweedy Browne $170,876,681 Joel Greenblatt $7,431,507

Holder Concentration

Across 496 13F filers
Top Holder
14.6%
Jun 2023 → Mar 2026 · range 13.3% – 15.6%
of institutional value
Top 5
41.5%
Jun 2023 → Mar 2026 · range 41.5% – 49.2%
of institutional value
Top 10
55.6%
Jun 2023 → Mar 2026 · range 55.6% – 65.0%
of institutional value
HHI
515
Jun 2023 → Mar 2026 · range 476 – 611
Broadly held
Showing 100 of 527
All Common Calls Puts
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Holder Value (USD) % of 13F Shares Open
Mega FMR LLC $1,843,957,869 14.58% 24,556,637
Mega Capital World Investors $1,590,884,448 12.58% 21,186,369
Mega BlackRock, Inc. $784,125,511 6.20% 10,442,476
Mega VANGUARD CAPITAL MANAGEMENT LLC $534,515,399 4.23% 7,118,330
Mega WELLINGTON MANAGEMENT GROUP LLP $479,961,458 3.79% 6,391,816
Mega T. Rowe Price Investment Management, Inc. $462,481,337 3.66% 6,159,027
Mega TWO SIGMA INVESTMENTS, LP $439,849,361 3.48% 5,857,629
Mega STATE STREET CORP $300,026,900 2.37% 3,995,564
Mega GEODE CAPITAL MANAGEMENT, LLC $299,183,489 2.37% 3,984,332
Mega ROYAL BANK OF CANADA Bank $285,478,282 2.26% 3,801,815
Mega PRICE T ROWE ASSOCIATES INC /MD/ $227,166,096 1.80% 3,025,251
Mega JPMORGAN CHASE & CO $177,480,242 1.40% 2,363,567
Mid Tweedy, Browne Co LLC $170,876,681 1.35% 2,275,625
Large Artisan Partners Limited Partnership $154,558,347 1.22% 2,058,308
Large BAKER BROS. ADVISORS LP $153,763,820 1.22% 2,047,727
Mid DEERFIELD MANAGEMENT COMPANY, L.P. $148,653,345 1.18% 1,979,669
Mid Deep Track Capital, LP $146,425,500 1.16% 1,950,000
Mid Bellevue Group AG $136,563,554 1.08% 1,818,665
Mega GOLDMAN SACHS GROUP INC $127,641,509 1.01% 1,699,847
Mega AMERICAN CENTURY COMPANIES INC $124,934,967 0.99% 1,663,803
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $118,887,443 0.94% 1,583,266
Mega FRANKLIN RESOURCES INC $118,268,476 0.93% 1,575,023
Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $110,805,201 0.88% 1,475,632
Large Pictet Asset Management Holding SA $107,753,774 0.85% 1,434,995
Mid SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC $105,428,837 0.83% 1,404,033
Mega Invesco Ltd. $95,916,809 0.76% 1,277,358
Mega MILLENNIUM MANAGEMENT LLC $78,957,585 0.62% 1,051,506
Mega MORGAN STANLEY $77,080,557 0.61% 1,026,509
Mega VANGUARD FIDUCIARY TRUST CO Bank $76,920,468 0.61% 1,024,377
Mega CITADEL ADVISORS LLC $70,774,877 0.56% 942,534
Large BNP PARIBAS ASSET MANAGEMENT Holding S.A. $68,146,652 0.54% 907,533
Large Connor, Clark & Lunn Investment Management Ltd. $65,635,343 0.52% 874,089
Mega NORTHERN TRUST CORP Bank $65,191,559 0.52% 868,179
Mega BANK OF AMERICA CORP /DE/ Bank $63,120,501 0.50% 840,598
Large Polar Capital Holdings Plc $62,287,980 0.49% 829,511
Mid GROUPAMA ASSET MANAGMENT $61,914,708 0.49% 824,540
Mega UBS Group AG $60,705,983 0.48% 808,443
Large NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $58,966,750 0.47% 785,281
Large GW&K Investment Management, LLC $58,521,315 0.46% 779,349
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $56,753,022 0.45% 755,800
Mega ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $55,405,832 0.44% 737,859
Large Squarepoint Ops LLC $52,208,274 0.41% 695,276
Large VOLORIDGE INVESTMENT MANAGEMENT, LLC $50,524,907 0.40% 672,858
Mega MASSACHUSETTS FINANCIAL SERVICES CO /MA/ $50,018,650 0.40% 666,116
Mega AMERIPRISE FINANCIAL INC $49,570,210 0.39% 660,144
Mega Nuveen, LLC $48,695,563 0.38% 648,496
Mid Eversept Partners, LP $47,464,389 0.38% 632,100
Mid EVENTIDE ASSET MANAGEMENT, LLC $43,176,750 0.34% 575,000
Mega TD Asset Management Inc $39,794,245 0.31% 529,954
Large TEACHER RETIREMENT SYSTEM OF TEXAS Pension $39,342,053 0.31% 523,932
Mega Bank of New York Mellon Corp Bank $38,642,583 0.31% 514,617
Mid PERCEPTIVE ADVISORS LLC $37,845,360 0.30% 504,000
Small BOONE CAPITAL MANAGEMENT LLC $37,584,196 0.30% 500,522
Large Candriam S.C.A. $36,347,539 0.29% 484,053
Mega BNP PARIBAS ARBITRAGE, SA $36,002,651 0.28% 479,460
Large Alyeska Investment Group, L.P. $35,528,833 0.28% 473,150
Mega FIRST TRUST ADVISORS LP $35,169,377 0.28% 468,363
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $34,113,387 0.27% 454,300
Mid SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC $33,790,500 0.27% 450,000
Mega NEUBERGER BERMAN GROUP LLC $33,285,294 0.26% 443,272
Mid PINNACLE ASSOCIATES LTD $32,773,556 0.26% 436,457
Mega D. E. Shaw & Co., Inc. $32,258,587 0.26% 429,599
Large Handelsbanken Fonder AB $30,384,800 0.24% 383,211
Mega ALLIANCEBERNSTEIN L.P. $30,086,235 0.24% 400,669
Small Davern Capital Partners, LP $29,052,546 0.23% 386,903
Mid C WorldWide Group Holding A/S $27,482,940 0.22% 366,000
Large NEW YORK STATE COMMON RETIREMENT FUND Pension $26,312,587 0.21% 350,414
Mega Capital Research Global Investors $24,255,196 0.19% 323,015
Large RENAISSANCE TECHNOLOGIES LLC $22,943,674 0.18% 305,549
Mega Swiss National Bank Bank $22,864,905 0.18% 304,500
Large DAVENPORT & Co LLC $22,515,188 0.18% 283,960
Large Hudson Bay Capital Management LP $22,159,059 0.18% 295,100
Mega Legal & General Group Plc $22,127,445 0.17% 294,679
Small Privium Fund Management B.V. $21,777,902 0.17% 290,024
Mega BARCLAYS PLC $21,766,636 0.17% 289,874
Large ARK Investment Management LLC $21,679,684 0.17% 288,716
Mega JANE STREET GROUP, LLC $21,678,483 0.17% 288,700
Mega JANE STREET GROUP, LLC $21,010,182 0.17% 279,800
Mid TimesSquare Capital Management, LLC $20,700,360 0.16% 275,674
Mega DIMENSIONAL FUND ADVISORS LP $20,065,172 0.16% 267,215
Mega California Public Employees Retirement System Pension $19,184,368 0.15% 255,485
Large HRT FINANCIAL LP $18,941,452 0.15% 252,250
Mega CITADEL ADVISORS LLC $18,644,847 0.15% 248,300
Large Zurich Insurance Group Ltd/FI Insurance $17,994,943 0.14% 239,645
Mid J. Goldman & Co LP $17,665,673 0.14% 235,260
Mega RAYMOND JAMES FINANCIAL INC $17,655,234 0.14% 235,121
Large ExodusPoint Capital Management, LP $17,051,737 0.13% 227,084
Small Orion Investment Co $16,896,376 0.13% 225,015
Large Universal- Beteiligungs- und Servicegesellschaft mbH $16,493,668 0.13% 219,652
Mid TOCQUEVILLE ASSET MANAGEMENT L.P. $16,461,229 0.13% 219,220
Large Trexquant Investment LP $16,042,603 0.13% 213,645
Mid Jump Financial, LLC $15,519,225 0.12% 206,675
Large STIFEL FINANCIAL CORP $14,770,427 0.12% 196,703
Large Corient Private Wealth LLC $14,762,618 0.12% 196,599
Mega JANE STREET GROUP, LLC $14,403,611 0.11% 191,818
Mega WELLS FARGO & COMPANY/MN $14,256,058 0.11% 189,853
Mega HSBC HOLDINGS PLC $13,964,260 0.11% 185,967
Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Pension $13,252,258 0.10% 176,485
Mega RHUMBLINE ADVISERS $13,023,609 0.10% 173,440
Small SECTOR GAMMA AS $12,725,352 0.10% 169,468
Key facts CIK 874015 CUSIP 462222100 13F (30d) 59 filings 39 filers Visit website Investor relations

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