IONS · Ionis Pharmaceuticals Inc · Holdings

$45.42 +0.02 (+0.04%)

Russell 1000 member Rebalance outlook locked

Market Cap

$7.54B

166.18M

Volume · Oct 20 2.49M Avg daily vol (3M) 3.28M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of IONS: 13F, 13D and 13G, insiders and funds →

Institutional holdings are being reconciled with SEC filings. Holder totals and changes may be incomplete until reconciliation finishes.

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 507

Total Value: $14,784,923,626

Total Shares: 186,794,025

Showing 1–100 of 539 holdings by value · page 1 of 6

Institutional Ownership Trend

27 quarters

Superinvestors Holding IONS

All superinvestors →

Tweedy Browne $180,805,859 Joel Greenblatt $9,614,071

Holder Concentration

Across 523 13F filers

Top Holder

13.2%

of institutional value

Top 5

38.8%

of institutional value

Top 10

53.7%

of institutional value

HHI

454

Broadly held

Who Holds IONS

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 516 filers, like-for-like change +4.1%; actively managed books +4.0%; index-like books +4.1%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	33.7%	282	+0.1%	40	31
Exempt adviser	0.4%	7	+141.0%	1	0
Adviser	18.6%	14	-2.1%	2	0
Bank	10.1%	25	+30.0%	1	0
Insurer	0.0%	2	-16.8%	0	1
Broker-dealer	0.0%	3	-6.5%	0	0
Benefit plan	0.6%	6	+0.7%	0	0
Non-US	1.7%	12	-22.1%	1	0
Holding company	26.4%	11	+5.8%	0	0
Registered fund	0.0%	0	—	0	0
Unknown	8.6%	154	+9.3%	17	14

Style	Share	Filers	Change	New	Exited
Index-like	20.9%	49	+4.1%	1	0
Systematic-like	6.2%	36	-5.7%	5	8
Concentrated	4.0%	75	+10.4%	15	10
Diversified active	68.9%	356	+4.7%	41	28
Not measured	0.0%	0	—	0	0
Unknown	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	47.9%	285	+5.6%	26	17
Medium turnover	34.3%	126	+4.2%	15	10
High turnover	7.1%	59	-9.8%	8	17
Unknown	10.7%	46	+7.5%	13	2
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	11.1%	68	+6.5%	19	13
Medium horizon	13.9%	94	-6.2%	11	8
Long horizon	67.6%	318	+5.6%	27	19
Unknown	7.4%	36	+8.5%	5	6
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	2.1%	118	+22.9%	28	20
$1B to $10B	8.8%	162	-6.2%	19	19
$10B to $100B	11.7%	152	+18.6%	13	6
$100B or more	77.5%	84	+3.0%	2	1
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	1.7%	143	+4.2%	21	13
Pooled investment vehicles	11.5%	56	-5.1%	10	12
Registered funds and BDCs	15.9%	38	-0.5%	3	1
Pension and profit sharing plans	0.1%	4	+2121.6%	1	0
Insurance companies	0.0%	2	-4.2%	0	0
Charitable organizations	0.0%	1	0.0%	0	0
Governments and sovereign funds	0.7%	6	+29.2%	1	2
Corporations	0.0%	1	-7.4%	0	0
Other investment advisers	0.0%	7	+90.8%	1	0
Other	0.0%	2	+542.5%	1	0
Diversified	3.7%	22	+10.1%	2	3
Unknown	66.3%	234	+6.2%	22	15

Private funds	Share	Filers	Change	New	Exited
Hedge funds	16.7%	80	+1.3%	10	11
Private equity funds	0.1%	13	-0.2%	0	1
Venture capital funds	0.3%	2	0.0%	0	1
Real estate funds	0.0%	6	+14.3%	1	1
Liquidity funds	0.0%	1	0.0%	0	0
Securitized asset funds	0.8%	1	-1.4%	0	0
Other private funds	2.7%	19	-2.2%	0	2
Mixed private funds	0.3%	3	-4.5%	0	0
Private funds, type not stated	0.5%	11	+4.4%	2	1
No private funds	12.5%	153	+0.7%	28	14
Unknown	65.9%	227	+5.9%	21	15

Location	Share	Filers	Change	New	Exited
United States	87.3%	409	+1.5%	51	40
Outside the US	12.7%	107	+26.2%	11	6

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 4 holders with no observed 2026-03-31 13F and 2 holders with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Conviction and Crowding

516 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

1.74% of filers hold it in their top 10

Mar 31, 2026: 16

Holders above 5%

median weight 0.009%

Mar 31, 2026: 6

Crowding

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Private-fund advisers

—

of shares outstanding

Institutional ownership

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Top 10 holders

55.9%

of 13F shares, Herfindahl 0.049

Active holders

+4.0%

like-for-like share change of active filers

5% stakes on record

0 13D, 6 13G (5 institutional, 1 passive, 0 exempt)

How long holders have held it value-weighted 15.7 quarters

Under 1 year 14.9% 1 to 3 years 20.4% 3 years or more 64.7% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net buyers of $0 (0 buying, 0 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$58.11

estimated per share

Mar 31, 2026: $55.58

Quarter-end price

$79.29

implied by 13F values

Estimated gain or loss

+36.4%

price against the estimated cost

Estimated at a loss

0.000%

of costed 13F value

Estimated cost covers 38.0% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies IONS's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	INSM INSMED Inc	20	0.241
2	ORKA Oruka Therapeutics, Inc.	14	0.229
3	NRIX Nurix Therapeutics, Inc.	11	0.221
4	BBIO BridgeBio Pharma, Inc.	14	0.212
5	CYTK Cytokinetics Inc	16	0.210
6	AVLN Avalyn Pharma Inc.	8	0.204
7	ALKS Alkermes plc.	13	0.202
8	ASND Ascendis Pharma A/S	14	0.202
9	CLDX Celldex Therapeutics, Inc.	11	0.198
10	KRYS Krystal Biotech, Inc.	12	0.198

Shareholder Targets

13F filers that own its peers but not IONS, quarter ended Jun 30, 2026

Found through its holder-overlap peers: INSM, ORKA, NRIX, BBIO, CYTK, AVLN, ALKS, ASND, CLDX, KRYS, ARWR, GLUE, CRNX, BMRN, BNTX, NTRA, NAMS, IRTC, GH, ARGX. 1,237 filers in all.

#	Filer	In peers	Of book	Largest peers
1	Avoro Capital Advisors LLC Registered adviser, Concentrated	$4,716,259,729 5 held	42.4%	ASND, KRYS, ARGX
2	RA CAPITAL MANAGEMENT, L.P. Registered adviser, Concentrated	$3,221,010,907 3 held	28.4%	ASND, NAMS, ORKA
3	RTW INVESTMENTS, LP Registered adviser, Diversified active	$2,558,010,891 8 held	21.8%	ARGX, INSM, ORKA
4	FARALLON CAPITAL MANAGEMENT LLC Registered adviser, Diversified active	$1,787,030,495 4 held	10.6%	BBIO, NTRA, CRNX
5	VIKING GLOBAL INVESTORS LP Registered adviser, Diversified active	$1,568,436,337 5 held	4.55%	BBIO, BMRN, ORKA
6	PRIMECAP MANAGEMENT CO/CA/ Registered adviser, Diversified active	$1,371,122,777 4 held	0.810%	BMRN, BNTX, ALKS
7	Dodge & Cox Registered adviser, Diversified active	$1,191,626,736 2 held	0.620%	BMRN, BNTX
8	Frazier Life Sciences Management, L.P. Registered adviser, Concentrated	$1,137,695,103 7 held	24.8%	NAMS, KRYS, BBIO
9	Duquesne Family Office LLC Unknown, Diversified active	$1,128,072,377 4 held	26.1%	NTRA, INSM, NAMS
10	Kohlberg Kravis Roberts & Co. L.P. Registered adviser, Concentrated	$987,677,120 1 held	17.9%	BBIO

Fund Ownership of IONS by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 15.90% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	2.74%	+0.43 pp	4,555,099	75
Index ETFs	13.16%	+0.21 pp	21,865,679	79
Active ETFs	1.60%	+0.22 pp	2,656,352	34
Active funds	30.54%	-1.83 pp	50,747,848	225
Unclassified	4.72%	+4.62 pp	7,835,957	18
All registered funds	52.75%	+3.65 pp	87,660,935	431

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 278 Exempt adviser 7 Adviser 14 Bank 25 Insurer 2 Broker-dealer 3 Benefit plan 6 Non-US 12 Holding company 11 Unknown 149

Showing 100 of 539

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$1,953,067,789

13.21%

24,631,956

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	13,396,893	$1,062,239,645	54.4%	Defined
FIDELITY MANAGEMENT TRUST CO	11,231,927	$890,579,491	45.6%	Defined
STRATEGIC ADVISERS LLC	60	$4,757	0.0%	Defined
Fidelity Diversifying Solutions LLC	3,076	$243,896	0.0%	Defined

Capital World Investors

$1,718,152,929

11.62%

21,669,226

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	21,669,226	$1,718,152,929	100.0%	Defined

BlackRock, Inc.

$848,772,480

5.74%

10,704,660

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	355,462	$28,184,581	3.3%	Sole
BlackRock Investment Management (Australia) Ltd	42,323	$3,355,790	0.4%	Sole
BlackRock Asset Management Canada Ltd	26,406	$2,093,731	0.2%	Sole
BLACKROCK (SINGAPORE) LTD.	1,331	$105,534	0.0%	Sole
BlackRock Investment Management, LLC	101,233	$8,026,764	0.9%	Sole
BLACKROCK ADVISORS LLC	384,198	$30,463,059	3.6%	Sole
BlackRock Fund Advisors	4,528,170	$359,038,599	42.3%	Sole
BlackRock Institutional Trust Company, N.A.	4,524,319	$358,733,253	42.3%	Sole
BlackRock Japan Co. Ltd	12,815	$1,016,101	0.1%	Sole
BlackRock Fund Managers Ltd.	29,319	$2,324,703	0.3%	Sole
BlackRock Investment Management (UK) Ltd.	121,878	$9,663,706	1.1%	Sole
BlackRock (Netherlands) B.V.	5,879	$466,145	0.1%	Sole
BlackRock Asset Management Ireland Ltd	351,472	$27,868,214	3.3%	Sole
BlackRock Advisors (UK) Ltd	2,874	$227,879	0.0%	Sole
BlackRock (Luxembourg) S.A.	30,961	$2,454,897	0.3%	Sole
BlackRock Life Ltd	560	$44,402	0.0%	Sole
BlackRock Asset Management Schweiz AG	26,234	$2,080,093	0.2%	Sole
Aperio Group, LLC	159,112	$12,615,990	1.5%	Sole
SpiderRock Advisors, LLC	114	$9,039	0.0%	Sole

VANGUARD PORTFOLIO MANAGEMENT LLC

$623,182,054

4.21%

7,859,529

WELLINGTON MANAGEMENT GROUP LLP

$606,680,693

4.10%

7,651,415

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	7,040,487	$558,240,214	92.0%	Defined
Wellington Managment Canada LLC	64,135	$5,085,264	0.8%	Defined
Wellington Management Japan Pte Ltd	2,553	$202,427	0.0%	Defined
Wellington Management Singapore Pte. Ltd.	37,005	$2,934,126	0.5%	Defined
Wellington Management International Ltd	93,556	$7,418,055	1.2%	Defined
Wellington Trust Company, NA joint	367,850	$29,166,826	4.8%	Defined
Wellington Management Australia Pty Ltd	16,211	$1,285,370	0.2%	Defined
Wellington Management Europe GmbH	29,618	$2,348,411	0.4%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$571,799,597

3.87%

7,211,497

TWO SIGMA INVESTMENTS, LP

$495,748,197

3.35%

6,252,342

ROYAL BANK OF CANADA

$490,208,754

3.32%

6,182,479

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC Global Asset Management Inc.	101,473	$8,045,794	1.6%	Defined
RBC Capital Markets, LLC	230,903	$18,308,298	3.7%	Defined
RBC Dominion Securities Inc.	46,010	$3,648,132	0.7%	Defined
RBC Phillips, Hager & North Investment Counsel Inc.	51,070	$4,049,340	0.8%	Defined
RBC Private Counsel (USA) Inc.	7,687	$609,502	0.1%	Defined
ROYAL TRUST CORP OF CANADA/	264	$20,932	0.0%	Defined
RBC Trust Co (Delaware) Ltd	1,877	$148,827	0.0%	Defined
RBC GLOBAL ASSET MANAGEMENT (UK) Ltd	3,082,539	$244,414,517	49.9%	Defined
Royal Bank of Canada (Channel Islands) Ltd	32,066	$2,542,513	0.5%	Defined
RBC Rochdale, LLC	886	$70,250	0.0%	Defined
RBC Dominion Securities Global Ltd	1,251	$99,191	0.0%	Defined
RBC Europe Ltd	8,514	$675,075	0.1%	Defined
Held directly	2,617,939	$207,576,383	42.3%	Sole

STATE STREET CORP

$343,710,097

2.32%

4,334,848

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	4,334,848	$343,710,097	100.0%	Defined

T. Rowe Price Investment Management, Inc.

$313,938,605

2.12%

3,959,372

GEODE CAPITAL MANAGEMENT, LLC

$284,177,262

1.92%

3,584,024

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	426,697	$33,832,805	11.9%	Defined
Held directly	3,157,327	$250,344,457	88.1%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$252,499,004

1.71%

3,184,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	181,014	$14,352,600	5.7%	Defined
Held directly	3,003,486	$238,146,404	94.3%	Sole

JPMORGAN CHASE & CO

$211,840,437

1.43%

2,671,717

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	295	$23,390	0.0%	Other
JPMorgan Chase Bank, N.A.	59,228	$4,696,188	2.2%	Defined
J.P. Morgan Investment Management Inc.	2,296,419	$182,083,062	86.0%	Defined
J.P. Morgan Securities LLC	19,275	$1,528,314	0.7%	Defined
J.P. Morgan Securities plc	2,250	$178,402	0.1%	Defined
JPMorgan Asset Management (UK) Ltd	283,646	$22,490,291	10.6%	Defined
55I, LLC	88	$6,977	0.0%	Other
J.P. Morgan SE	10,516	$833,813	0.4%	Defined

Artisan Partners Limited Partnership

$209,327,502

1.42%

2,640,024

Tweedy, Browne Co LLC

$180,805,859

1.22%

2,280,311

Deep Track Capital, LP

$174,438,000

1.18%

2,200,000

GOLDMAN SACHS GROUP INC

$167,297,536

1.13%

2,109,945

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	1,478,317	$117,215,754	70.1%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	614,226	$48,701,979	29.1%	Defined
GOLDMAN SACHS INTERNATIONAL	6,403	$507,693	0.3%	Defined
GOLDMAN SACHS BANK AG	2,633	$208,770	0.1%	Defined
GOLDMAN SACHS WEALTH SERVICES, L.P.	8,366	$663,340	0.4%	Defined

BAKER BROS. ADVISORS LP

$162,364,273

1.10%

2,047,727

DEERFIELD MANAGEMENT COMPANY, L.P.

$156,967,955

1.06%

1,979,669

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	1,979,669	$156,967,955	100.0%	Defined

AMERICAN CENTURY COMPANIES INC

$154,383,656

1.04%

1,947,076

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	1,947,076	$154,383,656	100.0%	Defined

FRANKLIN RESOURCES INC

$128,717,560

0.87%

1,623,377

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brandywine Global Investment Management, LLC	186	$14,747	0.0%	Defined
FIDUCIARY TRUST CO INTERNATIONAL	300	$23,787	0.0%	Defined
FIDUCIARY TRUST INTERNATIONAL LLC	1,148	$91,024	0.1%	Defined
FRANKLIN ADVISERS INC	1,621,743	$128,588,002	99.9%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$127,264,731

0.86%

1,605,054

BARCLAYS PLC

$127,112,653

0.86%

1,603,136

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	1,578,387	$125,150,305	98.5%	Defined
BARCLAYS CAPITAL INC.	23,414	$1,856,496	1.5%	Defined
Barclays Investment Solutions Ltd	1,335	$105,852	0.1%	Defined

Pictet Asset Management Holding SA

$126,625,971

0.86%

1,596,998

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$115,340,938

0.78%

1,454,672

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	88,590	$7,024,301	6.1%	Defined
UBS Asset Management Trust Company	99,937	$7,924,004	6.9%	Defined
UBS Asset Management Switzerland AG	777,539	$61,651,066	53.5%	Defined
UBS Asset Management (UK) Ltd.	43,228	$3,427,547	3.0%	Defined
Held directly	445,378	$35,314,020	30.6%	Defined

Polar Capital Holdings Plc

$115,289,325

0.78%

1,454,021

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	1,454,021	$115,289,325	100.0%	Defined

Alyeska Investment Group, L.P.

$112,426,559

0.76%

1,417,916

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$103,108,716

0.70%

1,300,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	1,300,400	$103,108,716	100.0%	Other

NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$103,108,081

0.70%

1,300,392

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	1,300,392	$103,108,081	100.0%	Defined

MORGAN STANLEY

$101,605,689

0.69%

1,281,444

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	1,337	$106,010	0.1%	Defined
MORGAN STANLEY & CO. LLC	13,864	$1,099,276	1.1%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	485,483	$38,493,947	37.9%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	4,966	$393,753	0.4%	Defined
MORGAN STANLEY SMITH BARNEY LLC	257,964	$20,453,964	20.1%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	456,362	$36,184,942	35.6%	Defined
EATON VANCE MANAGEMENT	26,778	$2,123,227	2.1%	Defined
Calvert Research & Management	34,690	$2,750,570	2.7%	Defined

Invesco Ltd.

$88,860,855

0.60%

1,120,707

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	825,861	$65,482,517	73.7%	Defined
Invesco Trust Co joint	67,093	$5,319,803	6.0%	Defined
Invesco Capital Management LLC	227,753	$18,058,535	20.3%	Defined

VANGUARD FIDUCIARY TRUST CO

$84,114,400

0.57%

1,060,845

Bellevue Group AG

$77,090,336

0.52%

972,258

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	944,577	$74,895,510	97.2%	Defined
Bellevue Asset Management AG	27,681	$2,194,826	2.8%	Defined

GROUPAMA ASSET MANAGMENT

$74,301,311

0.50%

937,083

NORTHERN TRUST CORP

$72,440,134

0.49%

913,610

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	805,102	$63,836,536	88.1%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	108,508	$8,603,598	11.9%	Defined

Capital International Investors

$65,316,247

0.44%

823,764

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	823,764	$65,316,247	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$65,184,309

0.44%

822,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	822,100	$65,184,309	100.0%	Other

Davern Capital Partners, LP

$63,329,636

0.43%

798,709

BANK OF AMERICA CORP /DE/

$62,717,594

0.42%

790,990

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	411,693	$32,643,137	52.0%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	44,597	$3,536,096	5.6%	Defined
BOFA SECURITIES, INC.	107,429	$8,518,045	13.6%	Defined
MERRILL LYNCH INTERNATIONAL	49,548	$3,928,660	6.3%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	177,723	$14,091,656	22.5%	Defined

SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC

$62,422,083

0.42%

787,263

GW&K Investment Management, LLC

$59,226,933

0.40%

746,966

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$58,216,223

0.39%

734,219

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	2,595	$205,757	0.4%	Defined
BNP Paribas Asset Management USA, Inc.	362,859	$28,771,090	49.4%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	368,765	$29,239,376	50.2%	Defined

Nuveen, LLC

$57,586,898

0.39%

726,282

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	47,077	$3,732,735	6.5%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	293,372	$23,261,465	40.4%	Defined
TEACHERS ADVISORS, LLC joint	385,833	$30,592,698	53.1%	Defined

Connor, Clark & Lunn Investment Management Ltd.

$54,253,072

0.37%

684,236

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	684,236	$54,253,072	100.0%	Sole

Eversept Partners, LP

$52,702,794

0.36%

664,684

VOLORIDGE INVESTMENT MANAGEMENT, LLC

$51,970,947

0.35%

655,454

MASSACHUSETTS FINANCIAL SERVICES CO /MA/

$51,682,490

0.35%

651,816

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MFS Heritage Trust CO	3,932	$311,768	0.6%	Defined
Held directly	647,884	$51,370,722	99.4%	Sole

NEUBERGER BERMAN GROUP LLC

$50,232,830

0.34%

633,533

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

$50,113,500

0.34%

632,028

Caption Management, LLC

$49,952,700

0.34%

630,000

UBS Group AG

$49,546,256

0.34%

624,874

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	23,879	$1,893,365	3.8%	Defined
UBS AG	505,161	$40,054,215	80.8%	Defined
UBS Switzerland AG	78,172	$6,198,257	12.5%	Defined
UBS Securities LLC	17,662	$1,400,419	2.8%	Defined

TimesSquare Capital Management, LLC

$48,689,610

0.33%

614,070

EVENTIDE ASSET MANAGEMENT, LLC

$45,591,750

0.31%

575,000

PERCEPTIVE ADVISORS LLC

$44,878,140

0.30%

566,000

RENAISSANCE TECHNOLOGIES LLC

$44,355,936

0.30%

559,414

JANE STREET GROUP, LLC

$44,045,595

0.30%

555,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	555,500	$44,045,595	100.0%	Defined

JANE STREET GROUP, LLC

$43,070,328

0.29%

543,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	543,200	$43,070,328	100.0%	Defined

Bank of New York Mellon Corp

$43,011,173

0.29%

542,454

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware	215	$17,047	0.0%	Defined
Mellon Investments Corporation joint	313,759	$24,877,950	57.8%	Defined
The Bank of New York Mellon	171,330	$13,584,755	31.6%	Defined
BNY Mellon, NA joint	46,514	$3,688,094	8.6%	Defined
BNY Mellon Advisors, Inc. joint	8,771	$695,452	1.6%	Defined
Newton Investment Management North America, LLC joint	1,863	$147,717	0.3%	Defined
Held directly	2	$158	0.0%	Defined

TEACHER RETIREMENT SYSTEM OF TEXAS

$41,414,514

0.28%

522,317

BOONE CAPITAL MANAGEMENT LLC

$41,228,976

0.28%

519,977

JANE STREET GROUP, LLC

$39,934,169

0.27%

503,647

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	24,872	$1,972,100	4.9%	Defined
Jane Street Global Trading, LLC	478,775	$37,962,069	95.1%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$39,648,964

0.27%

500,050

BNP PARIBAS ARBITRAGE, SA

$36,049,119

0.24%

454,649

Candriam S.C.A.

$35,285,556

0.24%

445,019

FIRST TRUST ADVISORS LP

$33,872,450

0.23%

427,197

NOMURA HOLDINGS INC

$31,889,803

0.22%

402,192

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA GLOBAL FINANCIAL PRODUCTS INC	402,192	$31,889,803	100.0%	Defined

Ikarian Capital, LLC

$31,716,000

0.21%

400,000

CITADEL ADVISORS LLC

$30,645,585

0.21%

386,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	386,500	$30,645,585	100.0%	Defined

Handelsbanken Fonder AB

$30,384,800

0.21%

383,211

C WorldWide Group Holding A/S

$29,020,140

0.20%

366,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 2	366,000	$29,020,140	100.0%	Defined

Caption Management, LLC

$27,426,411

0.19%

345,900

TD Asset Management Inc

$27,002,050

0.18%

340,548

ALLIANCEBERNSTEIN L.P.

$26,994,280

0.18%

340,450

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	340,450	$26,994,280	100.0%	Defined

Freestone Grove Partners LP

$26,955,983

0.18%

339,967

Qube Research & Technologies Ltd

$26,479,054

0.18%

333,952

Capital Research Global Investors

$26,319,205

0.18%

331,936

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	331,936	$26,319,205	100.0%	Defined

CAPITAL FUND MANAGEMENT S.A.

$26,130,336

0.18%

329,554

Carmignac Gestion

$25,452,090

0.17%

321,000

Privium Fund Management B.V.

$25,366,773

0.17%

319,924

Swiss National Bank

$24,976,350

0.17%

315,000

Jump Financial, LLC

$24,288,904

0.16%

306,330

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jump Trading Holdings, LLC joint	60,272	$4,778,966	19.7%	Defined
Leap GP LLC joint	246,058	$19,509,938	80.3%	Defined

ARK Investment Management LLC

$23,848,053

0.16%

300,770

Integral Health Asset Management, LLC

$23,787,000

0.16%

300,000

Ikarian Capital, LLC

$23,787,000

0.16%

300,000

Legal & General Group Plc

$23,722,297

0.16%

299,184

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	38,410	$3,045,528	12.8%	Defined
Legal & General Investment Management Ltd joint	260,774	$20,676,769	87.2%	Defined

D. E. Shaw & Co., Inc.

$23,552,379

0.16%

297,041

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	222,817	$17,667,159	75.0%	Defined
D. E. Shaw Investment Management, L.L.C. joint	74,224	$5,885,220	25.0%	Defined

MILLENNIUM MANAGEMENT LLC

$22,904,660

0.15%

288,872

Aberdeen Group plc

$21,995,046

0.15%

277,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	277,400	$21,995,046	100.0%	Defined

California Public Employees Retirement System

$21,475,141

0.15%

270,843

MILLENNIUM MANAGEMENT LLC

$20,417,175

0.14%

257,500

TOCQUEVILLE ASSET MANAGEMENT L.P.

$19,918,837

0.13%

251,215

PINNACLE ASSOCIATES LTD

$19,485,438

0.13%

436,404

RAYMOND JAMES FINANCIAL INC

$18,819,320

0.13%

237,348

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	62,051	$4,920,023	26.1%	Defined
Raymond James Financial Services Advisors, Inc.	123,672	$9,805,952	52.1%	Defined
ClariVest Asset Management LLC joint	18,060	$1,431,977	7.6%	Defined
CHARTWELL INVESTMENT PARTNERS, LLC joint	33,565	$2,661,368	14.1%	Defined

CITADEL ADVISORS LLC

$18,734,958

0.13%

236,284

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	325	$25,769	0.1%	Defined
Held directly	235,959	$18,709,189	99.9%	Defined

Universal- Beteiligungs- und Servicegesellschaft mbH

$18,514,135

0.13%

233,499

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH joint	233,499	$18,514,135	100.0%	Defined

CITADEL ADVISORS LLC

$18,434,925

0.12%

232,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	232,500	$18,434,925	100.0%	Defined

WELLS FARGO & COMPANY/MN

$17,936,426

0.12%

226,213

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	7,981	$632,813	3.5%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	91,368	$7,244,568	40.4%	Defined
WELLS FARGO CLEARING SERVICES, LLC	105,113	$8,334,409	46.5%	Defined
Wells Fargo Securities, LLC	18,576	$1,472,891	8.2%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	3,175	$251,745	1.4%	Defined

Empowered Funds, LLC

$17,692,927

0.12%

223,142

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Strive Asset Management, LLC	632	$50,111	0.3%	Other
The Burney Company	110,256	$8,742,198	49.4%	Other
Alpha Architect, LLC	108,014	$8,564,430	48.4%	Other
Cambria Investment Management, L.P.	2,885	$228,751	1.3%	Other
Warren Street Wealth Advisors	1,255	$99,508	0.6%	Other
Held directly	100	$7,929	0.0%	Sole

Orion Investment Co

$17,470,362

0.12%

220,335

Life Cycle Investment Partners Ltd

$17,435,553

0.12%

219,896

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Key facts CIK 874015 CUSIP 462222100 13F (30d) 47 filings 46 filers Visit website Investor relations