IONS · Ionis Pharmaceuticals Inc

$54.25 -3.88 (-6.67%)

Russell 1000 member Rebalance outlook locked

Market Cap

$9.65B

166.18M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 520

Total Value: $14,829,484,517

Total Shares: 187,028,438

Showing 1–100 of 552 holdings by value · page 1 of 6

Institutional Ownership Trend

26 quarters

Superinvestors Holding IONS

All superinvestors →

Tweedy Browne $180,805,859 Joel Greenblatt $9,614,071

Holder Concentration

Across 520 13F filers · Δ vs Mar 31, 2026

Top Holder

13.2%

−0.8 pts

Top 5

38.8%

−1.7 pts

Top 10

53.7%

−1.7 pts

HHI

454

Broadly held−36

Quarterly Activity

vs Mar 31, 2026

New

Increased

209

Decreased

158

Sold Out

Unchanged

Holder count: +20

Institutional value: +12.3%

Shares held: +6.3%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega ROYAL BANK OF CANADA	+2,380,664	6,182,479
Mega BARCLAYS PLC	+1,313,262	1,653,136
Mega WELLINGTON MANAGEMENT GROUP LLP	+1,259,599	7,651,415
Large Caption Management, LLC	+962,068	977,659
Large Alyeska Investment Group, L.P.	+944,766	1,417,916

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega T. Rowe Price Investment Management, Inc.	−2,199,655	3,959,372
Mid SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC	−1,066,770	787,263
Mid Bellevue Group AG	−846,407	972,258
Mega AMERIPRISE FINANCIAL INC	−592,439	67,705
Large Squarepoint Ops LLC	−585,897	109,379

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Capital International Investors	823,764	$65,316,247
Large Freestone Grove Partners LP	339,967	$26,955,983
Large Life Cycle Investment Partners Ltd	219,896	$17,435,553
Small Eagle Health Investments LP	194,577	$15,428,010
Mega NORGES BANK	114,359	$9,067,525

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Large Zurich Insurance Group Ltd/FI	239,645	$17,994,943
Mid WINTON GROUP Ltd	106,532	$7,999,487
Small Lisanti Capital Growth, LLC	75,699	$5,684,237
Mega JANUS HENDERSON GROUP PLC	68,191	$5,120,462
Small WEST MICHIGAN ADVISORS, LLC	44,614	$3,350,065

Filter: New 67 Increased 209 Reduced 158 Sold out 47 Unchanged 86

Showing 100 of 552

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$1,953,067,789

13.17%

24,631,956

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	13,396,893	$1,062,239,645	54.4%	Defined
FIDELITY MANAGEMENT TRUST CO	11,231,927	$890,579,491	45.6%	Defined
STRATEGIC ADVISERS LLC	60	$4,757	0.0%	Defined
Fidelity Diversifying Solutions LLC	3,076	$243,896	0.0%	Defined

Capital World Investors

$1,718,152,929

11.59%

21,669,226

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	21,669,226	$1,718,152,929	100.0%	Defined

BlackRock, Inc.

$848,772,480

5.72%

10,704,660

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	355,462	$28,184,581	3.3%	Sole
BlackRock Investment Management (Australia) Ltd	42,323	$3,355,790	0.4%	Sole
BlackRock Asset Management Canada Ltd	26,406	$2,093,731	0.2%	Sole
BLACKROCK (SINGAPORE) LTD.	1,331	$105,534	0.0%	Sole
BlackRock Investment Management, LLC	101,233	$8,026,764	0.9%	Sole
BLACKROCK ADVISORS LLC	384,198	$30,463,059	3.6%	Sole
BlackRock Fund Advisors	4,528,170	$359,038,599	42.3%	Sole
BlackRock Institutional Trust Company, N.A.	4,524,319	$358,733,253	42.3%	Sole
BlackRock Japan Co. Ltd	12,815	$1,016,101	0.1%	Sole
BlackRock Fund Managers Ltd.	29,319	$2,324,703	0.3%	Sole
BlackRock Investment Management (UK) Ltd.	121,878	$9,663,706	1.1%	Sole
BlackRock (Netherlands) B.V.	5,879	$466,145	0.1%	Sole
BlackRock Asset Management Ireland Ltd	351,472	$27,868,214	3.3%	Sole
BlackRock Advisors (UK) Ltd	2,874	$227,879	0.0%	Sole
BlackRock (Luxembourg) S.A.	30,961	$2,454,897	0.3%	Sole
BlackRock Life Ltd	560	$44,402	0.0%	Sole
BlackRock Asset Management Schweiz AG	26,234	$2,080,093	0.2%	Sole
Aperio Group, LLC	159,112	$12,615,990	1.5%	Sole
SpiderRock Advisors, LLC	114	$9,039	0.0%	Sole

VANGUARD PORTFOLIO MANAGEMENT LLC

$623,182,054

4.20%

7,859,529

WELLINGTON MANAGEMENT GROUP LLP

$606,680,693

4.09%

7,651,415

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	7,040,487	$558,240,214	92.0%	Defined
Wellington Managment Canada LLC	64,135	$5,085,264	0.8%	Defined
Wellington Management Japan Pte Ltd	2,553	$202,427	0.0%	Defined
Wellington Management Singapore Pte. Ltd.	37,005	$2,934,126	0.5%	Defined
Wellington Management International Ltd	93,556	$7,418,055	1.2%	Defined
Wellington Trust Company, NA joint	367,850	$29,166,826	4.8%	Defined
Wellington Management Australia Pty Ltd	16,211	$1,285,370	0.2%	Defined
Wellington Management Europe GmbH	29,618	$2,348,411	0.4%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$571,799,597

3.86%

7,211,497

TWO SIGMA INVESTMENTS, LP

$495,748,197

3.34%

6,252,342

ROYAL BANK OF CANADA

$490,208,754

3.31%

6,182,479

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC Global Asset Management Inc.	101,473	$8,045,794	1.6%	Defined
RBC Capital Markets, LLC	230,903	$18,308,298	3.7%	Defined
RBC Dominion Securities Inc.	46,010	$3,648,132	0.7%	Defined
RBC Phillips, Hager & North Investment Counsel Inc.	51,070	$4,049,340	0.8%	Defined
RBC Private Counsel (USA) Inc.	7,687	$609,502	0.1%	Defined
ROYAL TRUST CORP OF CANADA/	264	$20,932	0.0%	Defined
RBC Trust Co (Delaware) Ltd	1,877	$148,827	0.0%	Defined
RBC GLOBAL ASSET MANAGEMENT (UK) Ltd	3,082,539	$244,414,517	49.9%	Defined
Royal Bank of Canada (Channel Islands) Ltd	32,066	$2,542,513	0.5%	Defined
RBC Rochdale, LLC	886	$70,250	0.0%	Defined
RBC Dominion Securities Global Ltd	1,251	$99,191	0.0%	Defined
RBC Europe Ltd	8,514	$675,075	0.1%	Defined
Held directly	2,617,939	$207,576,383	42.3%	Sole

STATE STREET CORP

$343,710,097

2.32%

4,334,848

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	4,334,848	$343,710,097	100.0%	Defined

T. Rowe Price Investment Management, Inc.

$313,938,605

2.12%

3,959,372

GEODE CAPITAL MANAGEMENT, LLC

$284,177,262

1.92%

3,584,024

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	426,697	$33,832,805	11.9%	Defined
Held directly	3,157,327	$250,344,457	88.1%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$252,499,004

1.70%

3,184,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	181,014	$14,352,600	5.7%	Defined
Held directly	3,003,486	$238,146,404	94.3%	Sole

JPMORGAN CHASE & CO

$211,840,437

1.43%

2,671,717

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	295	$23,390	0.0%	Other
JPMorgan Chase Bank, N.A.	59,228	$4,696,188	2.2%	Defined
J.P. Morgan Investment Management Inc.	2,296,419	$182,083,062	86.0%	Defined
J.P. Morgan Securities LLC	19,275	$1,528,314	0.7%	Defined
J.P. Morgan Securities plc	2,250	$178,402	0.1%	Defined
JPMorgan Asset Management (UK) Ltd	283,646	$22,490,291	10.6%	Defined
55I, LLC	88	$6,977	0.0%	Other
J.P. Morgan SE	10,516	$833,813	0.4%	Defined

Artisan Partners Limited Partnership

$209,327,502

1.41%

2,640,024

Tweedy, Browne Co LLC

$180,805,859

1.22%

2,280,311

Deep Track Capital, LP

$174,438,000

1.18%

2,200,000

GOLDMAN SACHS GROUP INC

$167,297,536

1.13%

2,109,945

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	1,478,317	$117,215,754	70.1%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	614,226	$48,701,979	29.1%	Defined
GOLDMAN SACHS INTERNATIONAL	6,403	$507,693	0.3%	Defined
GOLDMAN SACHS BANK AG	2,633	$208,770	0.1%	Defined
GOLDMAN SACHS WEALTH SERVICES, L.P.	8,366	$663,340	0.4%	Defined

BAKER BROS. ADVISORS LP

$162,364,273

1.09%

2,047,727

DEERFIELD MANAGEMENT COMPANY, L.P.

$156,967,955

1.06%

1,979,669

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	1,979,669	$156,967,955	100.0%	Defined

AMERICAN CENTURY COMPANIES INC

$154,383,656

1.04%

1,947,076

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	1,947,076	$154,383,656	100.0%	Defined

FRANKLIN RESOURCES INC

$128,717,560

0.87%

1,623,377

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brandywine Global Investment Management, LLC	186	$14,747	0.0%	Defined
FIDUCIARY TRUST CO INTERNATIONAL	300	$23,787	0.0%	Defined
FIDUCIARY TRUST INTERNATIONAL LLC	1,148	$91,024	0.1%	Defined
FRANKLIN ADVISERS INC	1,621,743	$128,588,002	99.9%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$127,264,731

0.86%

1,605,054

BARCLAYS PLC

$127,112,653

0.86%

1,603,136

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	1,578,387	$125,150,305	98.5%	Defined
BARCLAYS CAPITAL INC.	23,414	$1,856,496	1.5%	Defined
Barclays Investment Solutions Ltd	1,335	$105,852	0.1%	Defined

Pictet Asset Management Holding SA

$126,625,971

0.85%

1,596,998

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$115,340,938

0.78%

1,454,672

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	88,590	$7,024,301	6.1%	Defined
UBS Asset Management Trust Company	99,937	$7,924,004	6.9%	Defined
UBS Asset Management Switzerland AG	777,539	$61,651,066	53.5%	Defined
UBS Asset Management (UK) Ltd.	43,228	$3,427,547	3.0%	Defined
Held directly	445,378	$35,314,020	30.6%	Defined

Polar Capital Holdings Plc

$115,289,325

0.78%

1,454,021

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	1,454,021	$115,289,325	100.0%	Defined

Alyeska Investment Group, L.P.

$112,426,559

0.76%

1,417,916

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$103,108,716

0.70%

1,300,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	1,300,400	$103,108,716	100.0%	Other

NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$103,108,081

0.70%

1,300,392

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	1,300,392	$103,108,081	100.0%	Defined

MORGAN STANLEY

$101,605,689

0.69%

1,281,444

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	1,337	$106,010	0.1%	Defined
MORGAN STANLEY & CO. LLC	13,864	$1,099,276	1.1%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	485,483	$38,493,947	37.9%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	4,966	$393,753	0.4%	Defined
MORGAN STANLEY SMITH BARNEY LLC	257,964	$20,453,964	20.1%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	456,362	$36,184,942	35.6%	Defined
EATON VANCE MANAGEMENT	26,778	$2,123,227	2.1%	Defined
Calvert Research & Management	34,690	$2,750,570	2.7%	Defined

Invesco Ltd.

$88,860,855

0.60%

1,120,707

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	825,861	$65,482,517	73.7%	Defined
Invesco Trust Co joint	67,093	$5,319,803	6.0%	Defined
Invesco Capital Management LLC	227,753	$18,058,535	20.3%	Defined

VANGUARD FIDUCIARY TRUST CO

$84,114,400

0.57%

1,060,845

Bellevue Group AG

$77,090,336

0.52%

972,258

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	944,577	$74,895,510	97.2%	Defined
Bellevue Asset Management AG	27,681	$2,194,826	2.8%	Defined

GROUPAMA ASSET MANAGMENT

$74,301,311

0.50%

937,083

NORTHERN TRUST CORP

$72,440,134

0.49%

913,610

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	805,102	$63,836,536	88.1%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	108,508	$8,603,598	11.9%	Defined

Capital International Investors

$65,316,247

0.44%

823,764

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	823,764	$65,316,247	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$65,184,309

0.44%

822,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	822,100	$65,184,309	100.0%	Other

Davern Capital Partners, LP

$63,329,636

0.43%

798,709

BANK OF AMERICA CORP /DE/

$62,717,594

0.42%

790,990

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	411,693	$32,643,137	52.0%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	44,597	$3,536,096	5.6%	Defined
BOFA SECURITIES, INC.	107,429	$8,518,045	13.6%	Defined
MERRILL LYNCH INTERNATIONAL	49,548	$3,928,660	6.3%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	177,723	$14,091,656	22.5%	Defined

SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC

$62,422,083

0.42%

787,263

GW&K Investment Management, LLC

$59,226,933

0.40%

746,966

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$58,216,223

0.39%

734,219

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	2,595	$205,757	0.4%	Defined
BNP Paribas Asset Management USA, Inc.	362,859	$28,771,090	49.4%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	368,765	$29,239,376	50.2%	Defined

Nuveen, LLC

$57,586,898

0.39%

726,282

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	47,077	$3,732,735	6.5%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	293,372	$23,261,465	40.4%	Defined
TEACHERS ADVISORS, LLC joint	385,833	$30,592,698	53.1%	Defined

Connor, Clark & Lunn Investment Management Ltd.

$54,253,072

0.37%

684,236

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	684,236	$54,253,072	100.0%	Sole

Eversept Partners, LP

$52,702,794

0.36%

664,684

VOLORIDGE INVESTMENT MANAGEMENT, LLC

$51,970,947

0.35%

655,454

MASSACHUSETTS FINANCIAL SERVICES CO /MA/

$51,682,490

0.35%

651,816

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MFS Heritage Trust CO	3,932	$311,768	0.6%	Defined
Held directly	647,884	$51,370,722	99.4%	Sole

NEUBERGER BERMAN GROUP LLC

$50,232,830

0.34%

633,533

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

$50,113,500

0.34%

632,028

Caption Management, LLC

$49,952,700

0.34%

630,000

UBS Group AG

$49,546,256

0.33%

624,874

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	23,879	$1,893,365	3.8%	Defined
UBS AG	505,161	$40,054,215	80.8%	Defined
UBS Switzerland AG	78,172	$6,198,257	12.5%	Defined
UBS Securities LLC	17,662	$1,400,419	2.8%	Defined

TimesSquare Capital Management, LLC

$48,689,610

0.33%

614,070

EVENTIDE ASSET MANAGEMENT, LLC

$45,591,750

0.31%

575,000

PERCEPTIVE ADVISORS LLC

$44,878,140

0.30%

566,000

RENAISSANCE TECHNOLOGIES LLC

$44,355,936

0.30%

559,414

JANE STREET GROUP, LLC

$44,045,595

0.30%

555,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	555,500	$44,045,595	100.0%	Defined

JANE STREET GROUP, LLC

$43,070,328

0.29%

543,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	543,200	$43,070,328	100.0%	Defined

Bank of New York Mellon Corp

$43,011,173

0.29%

542,454

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware	215	$17,047	0.0%	Defined
Mellon Investments Corporation joint	313,759	$24,877,950	57.8%	Defined
The Bank of New York Mellon	171,330	$13,584,755	31.6%	Defined
BNY Mellon, NA joint	46,514	$3,688,094	8.6%	Defined
BNY Mellon Advisors, Inc. joint	8,771	$695,452	1.6%	Defined
Newton Investment Management North America, LLC joint	1,863	$147,717	0.3%	Defined
Held directly	2	$158	0.0%	Defined

TEACHER RETIREMENT SYSTEM OF TEXAS

$41,414,514

0.28%

522,317

BOONE CAPITAL MANAGEMENT LLC

$41,228,976

0.28%

519,977

JANE STREET GROUP, LLC

$39,934,169

0.27%

503,647

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	24,872	$1,972,100	4.9%	Defined
Jane Street Global Trading, LLC	478,775	$37,962,069	95.1%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$39,648,964

0.27%

500,050

BNP PARIBAS ARBITRAGE, SA

$36,049,119

0.24%

454,649

Candriam S.C.A.

$35,285,556

0.24%

445,019

FIRST TRUST ADVISORS LP

$33,872,450

0.23%

427,197

PINNACLE ASSOCIATES LTD

$33,282,136

0.22%

419,752

NOMURA HOLDINGS INC

$31,889,803

0.22%

402,192

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA GLOBAL FINANCIAL PRODUCTS INC	402,192	$31,889,803	100.0%	Defined

Ikarian Capital, LLC

$31,716,000

0.21%

400,000

CITADEL ADVISORS LLC

$30,645,585

0.21%

386,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	386,500	$30,645,585	100.0%	Defined

Handelsbanken Fonder AB

$30,384,800

0.20%

383,211

C WorldWide Group Holding A/S

$29,020,140

0.20%

366,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 2	366,000	$29,020,140	100.0%	Defined

Caption Management, LLC

$27,426,411

0.18%

345,900

TD Asset Management Inc

$27,002,050

0.18%

340,548

ALLIANCEBERNSTEIN L.P.

$26,994,280

0.18%

340,450

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	340,450	$26,994,280	100.0%	Defined

Freestone Grove Partners LP

$26,955,983

0.18%

339,967

Qube Research & Technologies Ltd

$26,479,054

0.18%

333,952

Capital Research Global Investors

$26,319,205

0.18%

331,936

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	331,936	$26,319,205	100.0%	Defined

CAPITAL FUND MANAGEMENT S.A.

$26,130,336

0.18%

329,554

Carmignac Gestion

$25,452,090

0.17%

321,000

Privium Fund Management B.V.

$25,366,773

0.17%

319,924

Swiss National Bank

$24,976,350

0.17%

315,000

Jump Financial, LLC

$24,288,904

0.16%

306,330

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jump Trading Holdings, LLC joint	60,272	$4,778,966	19.7%	Defined
Leap GP LLC joint	246,058	$19,509,938	80.3%	Defined

ARK Investment Management LLC

$23,848,053

0.16%

300,770

Integral Health Asset Management, LLC

$23,787,000

0.16%

300,000

Ikarian Capital, LLC

$23,787,000

0.16%

300,000

Legal & General Group Plc

$23,722,297

0.16%

299,184

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	38,410	$3,045,528	12.8%	Defined
Legal & General Investment Management Ltd joint	260,774	$20,676,769	87.2%	Defined

D. E. Shaw & Co., Inc.

$23,552,379

0.16%

297,041

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	222,817	$17,667,159	75.0%	Defined
D. E. Shaw Investment Management, L.L.C. joint	74,224	$5,885,220	25.0%	Defined

MILLENNIUM MANAGEMENT LLC

$22,904,660

0.15%

288,872

DAVENPORT & Co LLC

$22,515,188

0.15%

283,960

Aberdeen Group plc

$21,995,046

0.15%

277,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	277,400	$21,995,046	100.0%	Defined

California Public Employees Retirement System

$21,475,141

0.14%

270,843

MILLENNIUM MANAGEMENT LLC

$20,417,175

0.14%

257,500

TOCQUEVILLE ASSET MANAGEMENT L.P.

$19,918,837

0.13%

251,215

RAYMOND JAMES FINANCIAL INC

$18,819,320

0.13%

237,348

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	62,051	$4,920,023	26.1%	Defined
Raymond James Financial Services Advisors, Inc.	123,672	$9,805,952	52.1%	Defined
ClariVest Asset Management LLC joint	18,060	$1,431,977	7.6%	Defined
CHARTWELL INVESTMENT PARTNERS, LLC joint	33,565	$2,661,368	14.1%	Defined

CITADEL ADVISORS LLC

$18,734,958

0.13%

236,284

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	325	$25,769	0.1%	Defined
Held directly	235,959	$18,709,189	99.9%	Defined

Universal- Beteiligungs- und Servicegesellschaft mbH

$18,514,135

0.12%

233,499

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH joint	233,499	$18,514,135	100.0%	Defined

CITADEL ADVISORS LLC

$18,434,925

0.12%

232,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	232,500	$18,434,925	100.0%	Defined

WELLS FARGO & COMPANY/MN

$17,936,426

0.12%

226,213

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	7,981	$632,813	3.5%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	91,368	$7,244,568	40.4%	Defined
WELLS FARGO CLEARING SERVICES, LLC	105,113	$8,334,409	46.5%	Defined
Wells Fargo Securities, LLC	18,576	$1,472,891	8.2%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	3,175	$251,745	1.4%	Defined

Empowered Funds, LLC

$17,692,927

0.12%

223,142

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Strive Asset Management, LLC	632	$50,111	0.3%	Other
The Burney Company	110,256	$8,742,198	49.4%	Other
Alpha Architect, LLC	108,014	$8,564,430	48.4%	Other
Cambria Investment Management, L.P.	2,885	$228,751	1.3%	Other
Warren Street Wealth Advisors	1,255	$99,508	0.6%	Other
Held directly	100	$7,929	0.0%	Sole

Orion Investment Co

$17,470,362

0.12%

220,335

Key facts CIK 874015 CUSIP 462222100 13F (30d) 369 filings 367 filers Visit website Investor relations