BBIO · BridgeBio Pharma, Inc. · Holdings

$68.15 -0.41 (-0.60%)

Russell 1000 member Rebalance outlook locked

Market Cap

$13.32B

195.49M

Volume · Oct 26 2.06M Avg daily vol (3M) 2.47M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of BBIO: 13F, 13D and 13G, insiders and funds →

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 485

Total Value: $15,360,194,131

Total Shares: 206,268,722

Showing 1–100 of 514 holdings by value · page 1 of 6

Institutional Ownership Trend

27 quarters

Superinvestors Holding BBIO

All superinvestors →

Andreas Halvorsen $741,017,831 Ray Dalio $33,377,690

Holder Concentration

Across 483 13F filers

Top Holder

6.8%

of institutional value

Top 5

28.3%

of institutional value

Top 10

44.1%

of institutional value

HHI

269

Broadly held

Who Holds BBIO

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 476 filers, like-for-like change -1.2%; actively managed books +2.7%; index-like books -15.3%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	52.6%	246	-4.1%	41	43
Exempt adviser	0.8%	9	+128.7%	4	0
Adviser	5.1%	12	-20.4%	2	2
Bank	6.9%	24	+2.2%	0	1
Insurer	0.5%	3	-27.5%	0	0
Broker-dealer	0.0%	1	+4.1%	0	0
Benefit plan	0.2%	6	+31.0%	1	0
Non-US	4.2%	15	+33.3%	2	2
Holding company	12.1%	13	-5.7%	0	0
Unknown	17.5%	147	+11.7%	28	21

Style	Share	Filers	Change	New	Exited
Index-like	19.1%	43	-15.3%	6	1
Systematic-like	8.8%	24	+54.7%	13	5
Concentrated	12.1%	81	-10.6%	14	20
Diversified active	60.1%	328	+0.8%	45	42
Unknown	0.0%	0	-100.0%	0	1
Not measured	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	40.1%	250	-12.9%	30	23
Medium turnover	23.7%	126	+4.9%	15	20
High turnover	18.6%	59	+25.0%	24	20
Unknown	17.5%	41	-0.5%	9	6
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	17.6%	61	+2.5%	23	16
Medium horizon	8.3%	84	-23.7%	10	19
Long horizon	60.3%	289	+1.6%	37	25
Unknown	13.8%	42	+0.4%	8	9
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	3.7%	112	-12.8%	24	28
$1B to $10B	12.4%	134	-8.2%	32	29
$10B to $100B	24.3%	149	+5.7%	22	9
$100B or more	59.6%	81	-1.4%	0	3
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	1.4%	118	+13.3%	20	20
Pooled investment vehicles	33.6%	58	+5.8%	13	13
Registered funds and BDCs	14.2%	32	-14.7%	1	1
Pension and profit sharing plans	0.0%	4	-51.2%	0	0
Insurance companies	0.0%	2	-92.1%	0	1
Charitable organizations	0.0%	1	+100.0%	0	0
Governments and sovereign funds	0.6%	7	-55.1%	1	2
Other investment advisers	0.0%	3	-10.5%	0	0
Other	0.1%	2	+110.3%	1	0
Diversified	2.7%	19	-22.3%	5	5
Corporations	0.0%	0	-100.0%	0	1
Unknown	47.4%	230	+2.3%	37	26

Private funds	Share	Filers	Change	New	Exited
Hedge funds	25.3%	69	+11.0%	16	17
Private equity funds	10.4%	15	-3.9%	2	2
Venture capital funds	0.5%	3	+2.6%	0	0
Real estate funds	0.0%	4	+17.7%	0	1
Liquidity funds	0.0%	1	-2.5%	0	0
Securitized asset funds	0.2%	1	+19.1%	0	0
Other private funds	3.0%	21	-28.5%	2	1
Mixed private funds	1.8%	6	-41.1%	0	0
Private funds, type not stated	0.0%	8	+185.9%	3	1
No private funds	12.2%	127	-11.1%	22	21
Unknown	46.6%	221	+1.4%	33	26

Location	Share	Filers	Change	New	Exited
United States	90.5%	382	-2.6%	62	60
Outside the US	9.5%	94	+17.1%	16	9

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 6 holders with no observed 2026-03-31 13F and 3 holders with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Conviction and Crowding

476 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

2.52% of filers hold it in their top 10

Mar 31, 2026: 16

Holders above 5%

median weight 0.009%

Mar 31, 2026: 7

Crowding

45.2%

of shares outstanding, 96th percentile

Private-fund advisers

40.7%

of shares outstanding

Institutional ownership

98.9%

111.7% of the estimated free float above 100%: filers can report lent or client shares more than once

Top 10 holders

45.7%

of 13F shares, Herfindahl 0.028

Active holders

+2.7%

like-for-like share change of active filers

5% stakes on record

2 13D, 4 13G (3 institutional, 1 passive, 0 exempt)

How long holders have held it value-weighted 14.2 quarters

Under 1 year 23.8% 1 to 3 years 25.4% 3 years or more 50.9% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net sellers of $41,206,014 (0 buying, 3 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$53.77

estimated per share

Mar 31, 2026: $46.32

Quarter-end price

$74.48

implied by 13F values

Estimated gain or loss

+38.5%

price against the estimated cost

Estimated at a loss

0.000%

of costed 13F value

Estimated cost covers 43.2% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies BBIO's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	CYTK Cytokinetics Inc	23	0.304
2	ELVN Enliven Therapeutics, Inc.	17	0.296
3	INSM INSMED Inc	22	0.267
4	RARE Ultragenyx Pharmaceutical Inc.	13	0.267
5	PCVX Vaxcyte, Inc.	14	0.257
6	PRAX Praxis Precision Medicines, Inc.	15	0.254
7	VERA Vera Therapeutics, Inc.	13	0.253
8	SRRK Scholar Rock Holding Corp	13	0.250
9	MDGL Madrigal Pharmaceuticals, Inc.	15	0.249
10	ORKA Oruka Therapeutics, Inc.	15	0.247

Shareholder Targets

13F filers that own its peers but not BBIO, quarter ended Jun 30, 2026

Found through its holder-overlap peers: CYTK, ELVN, INSM, RARE, PCVX, PRAX, VERA, SRRK, MDGL, ORKA, AXSM, COGT, ARWR, TNGX, SNDX, ROIV, MIRM, MLYS, RYTM, CRNX. 872 filers in all.

#	Filer	In peers	Of book	Largest peers
1	BAKER BROS. ADVISORS LP Registered adviser, Concentrated	$3,841,733,220 11 held	19.3%	MDGL, INSM, RYTM
2	RTW INVESTMENTS, LP Registered adviser, Diversified active	$2,913,644,436 7 held	24.9%	MDGL, INSM, TNGX
3	T. Rowe Price Investment Management, Inc. Adviser, Diversified active	$2,734,402,956 8 held	1.80%	CYTK, PCVX, INSM
4	Avoro Capital Advisors LLC Registered adviser, Concentrated	$2,581,561,390 4 held	23.2%	MDGL, ARWR, CYTK
5	RA CAPITAL MANAGEMENT, L.P. Registered adviser, Concentrated	$1,800,031,858 5 held	15.9%	RYTM, PCVX, MLYS
6	PERCEPTIVE ADVISORS LLC Registered adviser, Diversified active	$1,535,690,917 8 held	24.8%	PRAX, RYTM, ROIV
7	Orbis Allan Gray Ltd Unknown, Diversified active	$1,486,377,082 3 held	5.11%	INSM, PRAX, SRRK
8	Siren, L.L.C. Unknown, Diversified active	$1,289,400,655 9 held	26.2%	SRRK, TNGX, ARWR
9	DEERFIELD MANAGEMENT COMPANY, L.P. Registered adviser, Diversified active	$1,118,650,635 8 held	19.0%	PRAX, COGT, VERA
10	Deep Track Capital, LP Adviser, Diversified active	$1,055,979,170 8 held	16.1%	PCVX, ORKA, VERA

Fund Ownership of BBIO by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 14.95% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	2.87%	+0.16 pp	5,608,328	58
Index ETFs	12.08%	-1.17 pp	23,621,714	65
Active ETFs	0.66%	+0.13 pp	1,292,556	28
Active funds	16.12%	+1.99 pp	31,504,570	268
Unclassified	0.54%	+0.51 pp	1,049,626	26
All registered funds	32.27%	+1.62 pp	63,076,794	445

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 256 Exempt adviser 9 Adviser 11 Bank 24 Insurer 3 Broker-dealer 1 Benefit plan 6 Non-US 15 Holding company 13 Unknown 147

Showing 100 of 514

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

Jupiter Topco LLC

$1,050,933,503

6.84%

14,110,278

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	235,331	$17,527,452	1.7%	Defined
JANUS HENDERSON INVESTORS US LLC	13,724,900	$1,022,230,552	97.3%	Defined
Held directly	150,047	$11,175,499	1.1%	Defined

Kohlberg Kravis Roberts & Co. L.P.

$987,677,120

6.43%

13,260,971

FARALLON CAPITAL MANAGEMENT LLC

$800,143,332

5.21%

10,743,063

BlackRock, Inc.

$766,187,369

4.99%

10,287,156

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	174,514	$12,997,802	1.7%	Sole
BlackRock Investment Management (Australia) Ltd	378	$28,153	0.0%	Sole
BlackRock Asset Management Canada Ltd	20,222	$1,506,134	0.2%	Sole
BLACKROCK (SINGAPORE) LTD.	2,027	$150,970	0.0%	Sole
BlackRock Asset Management North Asia Ltd	9,802	$730,052	0.1%	Sole
BlackRock Investment Management, LLC	56,832	$4,232,847	0.6%	Sole
BLACKROCK ADVISORS LLC	242,913	$18,092,160	2.4%	Sole
BlackRock Fund Advisors	4,559,653	$339,602,955	44.3%	Sole
BlackRock Institutional Trust Company, N.A.	4,540,559	$338,180,834	44.1%	Sole
BlackRock Fund Managers Ltd.	27,368	$2,038,368	0.3%	Sole
BlackRock Investment Management (UK) Ltd.	71,093	$5,295,006	0.7%	Sole
BlackRock (Netherlands) B.V.	7,051	$525,158	0.1%	Sole
BlackRock Asset Management Ireland Ltd	339,375	$25,276,650	3.3%	Sole
BlackRock Advisors (UK) Ltd	2,678	$199,457	0.0%	Sole
BlackRock (Luxembourg) S.A.	3,733	$278,033	0.0%	Sole
BlackRock Life Ltd	668	$49,752	0.0%	Sole
BlackRock Asset Management Schweiz AG	24,973	$1,859,989	0.2%	Sole
Aperio Group, LLC	203,262	$15,138,953	2.0%	Sole
SpiderRock Advisors, LLC	55	$4,096	0.0%	Sole

VIKING GLOBAL INVESTORS LP

$741,017,831

4.82%

9,949,219

VANGUARD CAPITAL MANAGEMENT LLC

$588,315,509

3.83%

7,898,973

VANGUARD PORTFOLIO MANAGEMENT LLC

$570,272,654

3.71%

7,656,722

WELLINGTON MANAGEMENT GROUP LLP

$395,408,654

2.57%

5,308,924

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	4,837,281	$360,280,688	91.1%	Defined
Wellington Managment Canada LLC	1,677	$124,902	0.0%	Defined
Wellington Management Hong Kong Ltd	5,238	$390,126	0.1%	Defined
Wellington Management Singapore Pte. Ltd.	34,604	$2,577,305	0.7%	Defined
Wellington Management International Ltd	62,160	$4,629,676	1.2%	Defined
Wellington Trust Company, NA joint	350,347	$26,093,844	6.6%	Defined
Wellington Management Australia Pty Ltd	13,780	$1,026,334	0.3%	Defined
Wellington Management Europe GmbH	3,837	$285,779	0.1%	Defined

TWO SIGMA INVESTMENTS, LP

$351,708,338

2.29%

4,722,185

Aisling Capital Management LP

$341,834,227

2.23%

4,589,611

STATE STREET CORP

$330,388,215

2.15%

4,435,932

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	4,435,932	$330,388,215	100.0%	Defined

UBS Group AG

$287,753,480

1.87%

3,863,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	3,863,500	$287,753,480	100.0%	Defined

CITADEL ADVISORS LLC

$280,046,885

1.82%

3,760,028

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	653,309	$48,658,454	17.4%	Defined
Held directly	3,106,719	$231,388,431	82.6%	Defined

Invesco Ltd.

$275,645,559

1.79%

3,700,934

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	3,312,993	$246,751,716	89.5%	Defined
Invesco Trust Co joint	68,907	$5,132,193	1.9%	Defined
Invesco Asset Management Limited joint	137,543	$10,244,201	3.7%	Defined
Invesco Capital Management LLC	181,491	$13,517,449	4.9%	Defined

D. E. Shaw & Co., Inc.

$270,586,360

1.76%

3,633,007

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	2,932,412	$218,406,045	80.7%	Defined
D. E. Shaw Investment Management, L.L.C. joint	700,595	$52,180,315	19.3%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$254,603,846

1.66%

3,418,419

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	445,235	$33,161,102	13.0%	Defined
Held directly	2,973,184	$221,442,744	87.0%	Defined

JANE STREET GROUP, LLC

$232,407,392

1.51%

3,120,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	3,120,400	$232,407,392	100.0%	Defined

JANE STREET GROUP, LLC

$218,538,693

1.42%

2,934,193

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	1,515,908	$112,904,827	51.7%	Defined
Jane Street Global Trading, LLC	1,418,218	$105,628,876	48.3%	Defined
Jane Street Singapore Pte. Ltd	67	$4,990	0.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$195,152,496

1.27%

2,620,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	2,620,200	$195,152,496	100.0%	Other

JPMORGAN CHASE & CO

$178,602,663

1.16%

2,397,995

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	1,650	$122,891	0.1%	Other
JPMorgan Chase Bank, N.A.	40,784	$3,037,592	1.7%	Defined
J.P. Morgan Investment Management Inc.	2,043,840	$152,225,203	85.2%	Defined
J.P. Morgan Securities LLC	298,245	$22,213,286	12.4%	Defined
55I, LLC	16	$1,191	0.0%	Other
J.P. Morgan Markets Ltd	13,460	$1,002,500	0.6%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$167,728,960

1.09%

2,252,000

FRANKLIN RESOURCES INC

$160,889,683

1.05%

2,160,173

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fiduciary Trust International of the South	45	$3,351	0.0%	Defined
FIDUCIARY TRUST INTERNATIONAL LLC	254	$18,917	0.0%	Defined
FRANKLIN ADVISERS INC	2,159,680	$160,852,966	100.0%	Defined
Franklin Templeton International Services S.a r.l	194	$14,449	0.0%	Defined

Polar Capital Holdings Plc

$153,697,598

1.00%

2,063,609

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	2,063,609	$153,697,598	100.0%	Defined

FMR LLC

$153,526,144

1.00%

2,061,307

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	2,054,048	$152,985,495	99.6%	Defined
STRATEGIC ADVISERS LLC	7,027	$523,370	0.3%	Defined
FIAM LLC	184	$13,704	0.0%	Defined
Fidelity Diversifying Solutions LLC	48	$3,575	0.0%	Defined

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$145,662,993

0.95%

1,955,733

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	1,955,733	$145,662,993	100.0%	Defined

SC US (TTGP), LTD.

$138,559,910

0.90%

1,860,364

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SC U.S. Growth VIII Management, L.P.	1,860,364	$138,559,910	100.0%	Defined

GOLDMAN SACHS GROUP INC

$135,155,651

0.88%

1,814,657

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	887,729	$66,118,055	48.9%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	915,820	$68,210,273	50.5%	Defined
Goldman Sachs Trust Company, N.A.	11,108	$827,323	0.6%	Defined

UBS Group AG

$130,872,680

0.85%

1,757,152

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	344,894	$25,687,705	19.6%	Defined
UBS AG	1,405,414	$104,675,234	80.0%	Defined
UBS Switzerland AG	6,844	$509,741	0.4%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$128,581,005

0.84%

1,726,383

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	171,134	$12,746,060	9.9%	Defined
Held directly	1,555,249	$115,834,945	90.1%	Sole

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$127,317,377

0.83%

1,709,417

NORGES BANK

$126,152,213

0.82%

1,693,773

MORGAN STANLEY

$126,143,196

0.82%

1,693,652

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	4,005	$298,292	0.2%	Defined
MORGAN STANLEY & CO. LLC	100,398	$7,477,643	5.9%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	1,098,656	$81,827,898	64.9%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	452	$33,664	0.0%	Defined
MORGAN STANLEY SMITH BARNEY LLC	32,139	$2,393,712	1.9%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	410,703	$30,589,158	24.2%	Defined
EATON VANCE MANAGEMENT	47,299	$3,522,829	2.8%	Defined

AMERIPRISE FINANCIAL INC

$115,567,858

0.75%

1,551,663

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC joint	1,107,446	$82,482,577	71.4%	Defined
Ameriprise Trust Co	34,171	$2,545,056	2.2%	Defined
Threadneedle Asset Management Holdings LTD	388,519	$28,936,895	25.0%	Defined
Ameriprise Financial Services, LLC	583	$43,421	0.0%	Defined
Columbia Threadneedle Management Ltd	20,944	$1,559,909	1.3%	Defined

Frazier Life Sciences Management, L.P.

$115,305,392

0.75%

1,548,139

Point72 Asset Management, L.P.

$113,640,243

0.74%

1,525,782

ALLIANCEBERNSTEIN L.P.

$108,256,977

0.70%

1,453,504

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	1,453,504	$108,256,977	100.0%	Defined

Pictet Asset Management Holding SA

$107,856,424

0.70%

1,448,126

FRONTIER CAPITAL MANAGEMENT CO LLC

$102,265,285

0.67%

1,373,057

Laurion Capital Management LP

$100,714,388

0.66%

1,352,234

Hood River Capital Management LLC

$100,364,406

0.65%

1,347,535

BANK OF AMERICA CORP /DE/

$92,011,099

0.60%

1,235,380

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	562,278	$41,878,465	45.5%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	43,230	$3,219,770	3.5%	Defined
BOFA SECURITIES, INC.	120,628	$8,984,373	9.8%	Defined
MERRILL LYNCH INTERNATIONAL	3,535	$263,286	0.3%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	505,709	$37,665,205	40.9%	Defined

Balyasny Asset Management L.P.

$91,614,272

0.60%

1,230,052

Squarepoint Ops LLC

$88,760,199

0.58%

1,191,732

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	1,191,732	$88,760,199	100.0%	Defined

Bellevue Group AG

$88,594,406

0.58%

1,189,506

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	1,170,130	$87,151,282	98.4%	Defined
Bellevue Asset Management AG	19,376	$1,443,124	1.6%	Defined

BNP PARIBAS ARBITRAGE, SA

$86,057,320

0.56%

1,155,442

GW&K Investment Management, LLC

$83,799,756

0.55%

1,125,131

VANGUARD FIDUCIARY TRUST CO

$83,193,340

0.54%

1,116,989

HRT FINANCIAL LP

$81,136,724

0.53%

1,089,376

PRINCIPAL FINANCIAL GROUP INC

$76,299,024

0.50%

1,024,423

PRIMECAP MANAGEMENT CO/CA/

$75,670,190

0.49%

1,015,980

FIL Ltd

$74,648,324

0.49%

1,002,260

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIL Investments International	1,002,260	$74,648,324	100.0%	Defined

Clearbridge Investments, LLC

$73,966,311

0.48%

993,103

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$73,400,040

0.48%

985,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	985,500	$73,400,040	100.0%	Other

NORTHERN TRUST CORP

$71,464,527

0.47%

959,513

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	852,104	$63,464,705	88.8%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	107,409	$7,999,822	11.2%	Defined

CITIGROUP INC

$64,358,241

0.42%

864,101

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citibank, N.A. joint	221	$16,460	0.0%	Defined
Citigroup Financial Products Inc. joint	863,880	$64,341,781	100.0%	Defined

RENAISSANCE TECHNOLOGIES LLC

$63,817,890

0.42%

856,846

NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$61,803,652

0.40%

829,802

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	829,802	$61,803,652	100.0%	Defined

Ensign Peak Advisors, Inc

$56,677,566

0.37%

760,977

Allspring Global Investments Holdings, LLC

$55,304,900

0.36%

742,547

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Allspring Funds Management, LLC reporting on behalf of Morgan Stanley Smith Barney, LLC	28,911	$2,153,291	3.9%	Other
Allspring Global Investments, LLC reporting on behalf of UBS ASSET MANAGEMENT AMERICAS INC	713,636	$53,151,609	96.1%	Defined

Qube Research & Technologies Ltd

$54,162,228

0.35%

727,205

BARCLAYS PLC

$53,210,224

0.35%

714,423

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	685,711	$51,071,755	96.0%	Defined
BARCLAYS CAPITAL INC.	28,712	$2,138,469	4.0%	Defined

Capital Research Global Investors

$52,143,969

0.34%

700,107

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	700,107	$52,143,969	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$48,652,123

0.32%

653,224

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	653,224	$48,652,123	100.0%	Other

First Turn Management, LLC

$47,172,950

0.31%

633,364

AMERICAN CENTURY COMPANIES INC

$46,288,873

0.30%

621,494

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	621,494	$46,288,873	100.0%	Defined

SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC

$46,261,390

0.30%

621,125

DIMENSIONAL FUND ADVISORS LP

$46,112,502

0.30%

619,126

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	14,056	$1,046,890	2.3%	Defined
DFA Australia Ltd.	40,489	$3,015,620	6.5%	Defined
Dimensional Fund Advisors Pte. Ltd.	920	$68,521	0.1%	Defined
Dimensional Ireland Ltd	91,367	$6,805,014	14.8%	Defined
Held directly	472,294	$35,176,457	76.3%	Sole

Nuveen, LLC

$42,661,323

0.28%

572,789

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	65,454	$4,875,013	11.4%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	134,747	$10,035,956	23.5%	Defined
TEACHERS ADVISORS, LLC joint	372,588	$27,750,354	65.0%	Defined

NEUBERGER BERMAN GROUP LLC

$41,124,727

0.27%

552,158

Bank of New York Mellon Corp

$41,036,089

0.27%

550,968

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware joint	1,775	$132,201	0.3%	Defined
Mellon Investments Corporation joint	289,526	$21,563,895	52.5%	Defined
The Bank of New York Mellon	183,608	$13,675,123	33.3%	Defined
BNY Mellon, NA joint	62,622	$4,664,085	11.4%	Defined
BNY Mellon Advisors, Inc. joint	11,580	$862,477	2.1%	Other
Newton Investment Management North America, LLC joint	1,855	$138,160	0.3%	Defined
Held directly	2	$148	0.0%	Defined

Cormorant Asset Management, LP

$40,964,000

0.27%

550,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Chen Bihua	550,000	$40,964,000	100.0%	Defined

GILDER GAGNON HOWE & CO LLC

$40,884,008

0.27%

548,926

FEDERATED HERMES, INC.

$39,003,536

0.25%

523,678

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED EQUITY MANAGEMENT CO OF PENNSYLVANIA	21,642	$1,611,896	4.1%	Defined
FEDERATED MDTA LLC	487,960	$36,343,260	93.2%	Defined
HERMES INVESTMENT MANAGEMENT LTD	14,076	$1,048,380	2.7%	Defined

LORD, ABBETT & CO. LLC

$37,214,602

0.24%

499,659

MILLENNIUM MANAGEMENT LLC

$36,316,001

0.24%

487,594

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$35,732,372

0.23%

479,758

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	81,806	$6,092,910	17.1%	Defined
UBS Asset Management Switzerland AG	346,256	$25,789,146	72.2%	Defined
UBS Asset Management (UK) Ltd.	26,213	$1,952,343	5.5%	Defined
Held directly	25,483	$1,897,973	5.3%	Defined

Catalio Capital Management, LP

$33,891,453

0.22%

455,041

Bridgewater Associates, LP

$33,377,690

0.22%

448,143

EVENTIDE ASSET MANAGEMENT, LLC

$32,557,442

0.21%

437,130

Russell Investments Group, Ltd.

$27,877,264

0.18%

374,292

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	211,114	$15,723,769	56.4%	Defined
Russell Investments Capital, LLC	70,456	$5,247,562	18.8%	Defined
Russell Investments France SAS	19,687	$1,466,287	5.3%	Defined
Russell Investments Implementation Services, LLC	32,838	$2,445,774	8.8%	Defined
Russell Investments Trust Company	40,197	$2,993,872	10.7%	Defined

Fisher Asset Management, LLC

$25,721,742

0.17%

345,351

BOONE CAPITAL MANAGEMENT LLC

$25,302,345

0.16%

339,720

NOMURA HOLDINGS INC

$24,390,338

0.16%

327,475

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA GLOBAL FINANCIAL PRODUCTS INC	327,475	$24,390,338	100.0%	Defined

Weiss Asset Management LP

$23,847,304

0.16%

320,184

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WEISS ANDREW M joint	320,184	$23,847,304	100.0%	Defined

Fiera Capital Corp

$23,543,202

0.15%

316,101

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fiera Capital Inc.	309,217	$23,030,482	97.8%	Other
Held directly	6,884	$512,720	2.2%	Sole

Nicholas Investment Partners, LP

$23,200,073

0.15%

311,494

Woodline Partners LP

$22,441,717

0.15%

301,312

Candriam S.C.A.

$22,382,729

0.15%

300,520

Legal & General Group Plc

$22,305,418

0.15%

299,482

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	30,264	$2,254,062	10.1%	Defined
Legal & General Investment Management Ltd joint	269,218	$20,051,356	89.9%	Defined

MACKENZIE FINANCIAL CORP

$22,227,811

0.14%

298,440

Swiss National Bank

$21,941,808

0.14%

294,600

CITADEL ADVISORS LLC

$21,278,936

0.14%

285,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	285,700	$21,278,936	100.0%	Defined

CITADEL ADVISORS LLC

$20,943,776

0.14%

281,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	281,200	$20,943,776	100.0%	Defined

DEUTSCHE BANK AG\

$20,665,665

0.13%

277,466

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deutsche Bank Trust Co Americas	4,102	$305,516	1.5%	Defined
DWS Investment GmbH	114,507	$8,528,481	41.3%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	89,989	$6,702,380	32.4%	Defined
DWS Investments UK Ltd	18,925	$1,409,534	6.8%	Defined
DWS International GmbH	49,943	$3,719,754	18.0%	Defined

MARSHALL WACE, LLP

$20,520,431

0.13%

275,516

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	275,516	$20,520,431	100.0%	Other

Integral Health Asset Management, LLC

$20,482,000

0.13%

275,000

NOMURA HOLDINGS INC

$19,811,680

0.13%

266,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA SECURITIES INTERNATIONAL INC	266,000	$19,811,680	100.0%	Defined

PFM Health Sciences, LP

$18,870,103

0.12%

253,358

FIRST TRUST ADVISORS LP

$18,451,526

0.12%

247,738

SEI INVESTMENTS CO

$18,447,056

0.12%

247,678

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	51,563	$3,840,411	20.8%	Defined
SEI TRUST CO	196,115	$14,606,645	79.2%	Sole

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Key facts CIK 1743881 CUSIP 10806X102 13F (30d) 62 filings 58 filers Visit website Investor relations