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IONS · Ionis Pharmaceuticals Inc

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$57.24 +1.37 (+2.45%) At close · Aug 14
Market Cap
$9.51B
Shares
166.18M

Ionis Pharmaceuticals Inc Earnings Call Transcripts

Every quarterly earnings call for Ionis Pharmaceuticals Inc (IONS) — the full transcript with speaker labels, the audio replay, AI call highlights and a management-tone score, plus the matching 8-K earnings release and the quarter's 10-Q or 10-K. Investor days and conferences appear here too.

Earnings call
FY26 · Q2
2026-07-29
Second Quarter 2026 Financial Results Webcast
Positive tone Tringolza (Tryngolza) SHTG launch Eplontersin ATTR cardiomyopathy Phase 3 disappointment Tringolza FCS commercial execution
Revenue
$267.95M
▼ 40.7% YoY
Diluted EPS
$-0.69
▼ 198.6% YoY
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Conference
Investor event
2026-06-10
Goldman Sachs 47th Annual Global Healthcare Conference
No reported result — non-financial event
Audio Transcript Slides
Earnings call
FY26 · Q1
2026-04-29
Ionis Pharmaceuticals Inc Q1 FY2026 Earnings Call
Confident tone Tryngolza (olezarsen FCS) launch momentum DAWNZERA (donidalorsen) launch in HAE Olezarsen SHTG launch preparation and peak sales raise
Revenue
$246.09M
▲ 87% YoY
Diluted EPS
$-0.56
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY25 · Q4
2026-02-25
Ionis Pharmaceuticals Inc Q4 FY2025 Earnings Call
Confident tone Olezarsen in severe hypertriglyceridemia DAWNZERA launch in HAE TRYNGOLZA launch and FCS franchise
Revenue
$203.33M
▼ 10.3% YoY
Diluted EPS
$-1.41
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-K
Earnings call
FY25 · Q3
2025-10-29
Ionis Pharmaceuticals Inc Q3 FY2025 Earnings Call
Confident tone Tringolza launch (FCS) Olezarsen (olazarsen/olisarcin) in SHTG Donzara / HAE launch
Revenue
$156.72M
▲ 17.1% YoY
Diluted EPS
$-0.80
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY25 · Q2
2025-07-30
Ionis Pharmaceuticals Inc Q2 FY2025 Earnings Call
Confident tone Donidalorsen approval and HAE launch preparation CORE1/CORE2 acute pancreatitis readout risk Olezarsen severe hypertriglyceridemia opportunity
Revenue
$452.05M
▲ 100.7% YoY
Diluted EPS
$0.70
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY25 · Q1
2025-04-30
Ionis Pharmaceuticals Inc Q1 FY2025 Earnings Call
Confident tone TRYNGOLZA (olezarsen/FCS) launch donidalorsen / hereditary angioedema (HAE) Raised 2025 financial guidance
Revenue
$131.61M
▲ 10.1% YoY
Diluted EPS
$-0.93
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY24 · Q4
2025-02-19
Ionis Pharmaceuticals Inc Q4 FY2024 Earnings Call
Confident tone Tringolza independent launch in FCS Pipeline of independent launches Olezarsen SHTG opportunity
Revenue
$226.58M
▼ 30.2% YoY
Diluted EPS
$-0.66
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-K
Earnings call
FY24 · Q3
2024-11-06
Ionis Pharmaceuticals Inc Q3 FY2024 Earnings Call
Confident tone Olezarsen launch and FCS approval ION582 / Angelman syndrome program Donidalorsen for HAE
Revenue
$133.81M
▼ 7.2% YoY
Diluted EPS
$-0.95
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY24 · Q2
2024-08-01
Ionis Pharmaceuticals Inc Q2 FY2024 Earnings Call
Confident tone WAINUA launch and global expansion Olezarsen for FCS and sHTG QALSODY availability and ALS
Revenue
$225.25M
▲ 19.6% YoY
Diluted EPS
$-0.45
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY24 · Q1
2024-05-07
Ionis Pharmaceuticals Inc Q1 FY2024 Earnings Call
Confident tone Olezarsen for FCS and SHTG Donidalorsen for HAE ION224 / DGAT2 for MASH and partnering
Revenue
$119.50M
▼ 8.4% YoY
Diluted EPS
$-0.98
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY23 · Q4
2024-02-21
Ionis Pharmaceuticals Inc Q4 FY2023 Earnings Call
Confident tone WAINUA launch and ATTR franchise Donidalorsen for HAE Olezarsen for FCS
Revenue
$324.50M
▲ 113.6% YoY
Diluted EPS
$-0.06
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-K
Earnings call
FY23 · Q3
2023-11-02
Ionis Pharmaceuticals Inc Q3 FY2023 Earnings Call
Revenue
$144.21M
▼ 9.7% YoY
Diluted EPS
$-1.03
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY23 · Q2
2023-08-09
Ionis Pharmaceuticals Inc Q2 FY2023 Earnings Call
Revenue
$188.41M
▲ 40.8% YoY
Diluted EPS
$-0.60
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY23 · Q1
2023-05-03
Ionis Pharmaceuticals Inc Q1 FY2023 Earnings Call
Revenue
$130.52M
▼ 8% YoY
Diluted EPS
$-0.87
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY22 · Q4
2023-02-22
Ionis Pharmaceuticals Inc Q4 FY2022 Earnings Call
Revenue
$151.89M
▼ 65.5% YoY
Diluted EPS
$-0.37
▼ 126.2% YoY
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-K
Earnings call
FY22 · Q3
2022-11-14
Ionis Pharmaceuticals Inc Q3 FY2022 Earnings Call
Revenue
$159.77M
▲ 20% YoY
Diluted EPS
$-0.33
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY22 · Q2
2022-08-09
Ionis Pharmaceuticals Inc Q2 FY2022 Earnings Call
Revenue
$133.79M
▲ 6.4% YoY
Diluted EPS
$-0.74
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY22 · Q1
2022-05-04
Ionis Pharmaceuticals Inc Q1 FY2022 Earnings Call
Revenue
$141.92M
▲ 27.2% YoY
Diluted EPS
$-0.46
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY21 · Q4
2022-02-24
Ionis Pharmaceuticals Inc Q4 FY2021 Earnings Call
Revenue
$440.01M
▲ 51.6% YoY
Diluted EPS
$1.41
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-K
Earnings call
FY21 · Q3
2021-11-03
Ionis Pharmaceuticals Inc Q3 FY2021 Earnings Call
Revenue
$133.09M
▼ 16.9% YoY
Diluted EPS
$-0.58
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY21 · Q2
2021-08-04
Ionis Pharmaceuticals Inc Q2 FY2021 Earnings Call
Revenue
$125.75M
▼ 13.6% YoY
Diluted EPS
$-0.57
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY21 · Q1
2021-05-05
Ionis Pharmaceuticals Inc Q1 FY2021 Earnings Call
Revenue
$111.61M
▼ 16.3% YoY
Diluted EPS
$-0.64
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY20 · Q4
2021-02-24
Ionis Pharmaceuticals Inc Q4 FY2020 Earnings Call
Revenue
$290.28M
▼ 41.2% YoY
Diluted EPS
$-2.54
▼ 298.4% YoY
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-K
Earnings call
FY20 · Q3
2020-11-04
Ionis Pharmaceuticals Inc Q3 FY2020 Earnings Call
Revenue
$160.08M
▼ 4.7% YoY
Diluted EPS
$-0.18
▼ 200% YoY
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY20 · Q2
2020-08-05
Ionis Pharmaceuticals Inc Q2 FY2020 Earnings Call
Revenue
$145.54M
▼ 11.2% YoY
Diluted EPS
$-0.18
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY20 · Q1
2020-05-06
Ionis Pharmaceuticals Inc Q1 FY2020 Earnings Call
Revenue
$133.37M
▼ 55.1% YoY
Diluted EPS
$-0.28
▼ 145.2% YoY
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-Q
Earnings call
FY19 · Q4
2020-02-26
Ionis Pharmaceuticals Inc Q4 FY2019 Earnings Call
Revenue
$493.68M
▲ 157% YoY
Diluted EPS
$1.28
▼ 42.1% YoY
Rev · 8q Trailing quarterly revenue
Audio Transcript Slides 8-K10-K
Showing 1–28 of 28 earnings calls
Key facts CIK 874015 CUSIP 462222100 13F (30d) 498 filings 470 filers Visit website Investor relations