IONS · Ionis Pharmaceuticals Inc
Price & Indicators
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AI Brief
TL;DR.
AI-generated from the earnings call and 8-K · may contain errors · not investment advice
Ask ALVIS about this →Equibles Rating
blended score · not investment adviceBlended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.
Guidance & track record
Guidance from company 8-Ks · delivered figures from as-reported statements · no analyst estimates involved.
Technicals
trend & momentum for long-term holders NeutralIllustrative technical + ownership context — a signal mix, not investment advice.
Key metrics
the company's own KPIs, from written earnings releases and filings| Metric | Latest | Period | YoY |
|---|---|---|---|
| DAWNZERA U.S. net product sales | $42M | first half | — |
| Income (loss) from operations on a non-GAAP basis non-GAAP | -$131M | Six months ended June 30 | — |
| Operating expenses on a non-GAAP basis non-GAAP | $645M | Six months ended June 30 | — |
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| TRYNGOLZA U.S. net product sales | $32M | first half | — |
| Cash and short-term investments | 1.9B | As of March 31, 2026 | — |
| DAWNZERA sales, net | 16M | Q1 2026 | — |
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| TRYNGOLZA sales, net | 27M | Q1 2026 | — |
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| Loss from operations on a non-GAAP basis non-GAAP | -248M | Year ended December 31, 2025 | — |
| WAINUA sales | 212M | Year ended December 31, 2025 | — |
Figures exactly as the company stated them in writing · click a metric with a to chart its history · period links open the stating document · "filing" marks figures stated in the 10-K/10-Q · YoY needs an exactly comparable prior-year period
Versus peers
Biotechnology — same industry group| Company | Mkt cap | YTD | Rev growth Y/Y | P/E | Short % shares |
|---|---|---|---|---|---|
|
IONS
this stock
Ionis Pharmaceuticals Inc
|
$9.51B | -27.6% | +46.5% | — | 12.9% |
|
ONC
BeOne Medicines Ltd.
|
$513.62B | +14.4% | +22179.2% | 789.7 | 0.1% |
|
VRTX
Vertex Pharmaceuticals Inc / Ma
|
$128.19B | +11.6% | +46.2% | 29.5 | 1.6% |
|
REGN
Regeneron Pharmaceuticals, Inc.
|
$82.72B | +4.1% | +20.8% | 19.9 | 3.3% |
|
ARGX
Argenx SE
|
$52.94B | +1.2% | — | — | 2.1% |
Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding
At a glance
key data from every sectionPerformance
| 5D | 20D | 120D | MTD | YTD | |
|---|---|---|---|---|---|
| IONS | +1.2% | +5.2% | -32.3% | +10.6% | -27.7% |
| SPY | +0.4% | +4.5% | +13.8% | +3.9% | +13.9% |
| vs SPY | +0.8% | +0.8% | -46.1% | +6.7% | -41.5% |
Capital returns
Dividends per share over the trailing 365 days by ex-date · buyback figures as last reported in SEC filings ("spent" derived as authorized − remaining; when several programs run concurrently, authorized is their combined total per the newest filing) · components shown separately — trailing-year buyback spend isn't tracked, so no combined shareholder yield is derived.