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IONS · Ionis Pharmaceuticals Inc

Track IONS — free
$43.54 -0.46 (-1.05%) At close · Oct 2
Market Cap
$7.40B
Shares
166.18M
Volume · Oct 2 2.31M Avg daily vol (3M) 3.76M

Price & Indicators

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20d MA 50d MA 200d MA Earnings Filing Insider Congress Investor day
Close$43.54 Open$44.17 Day$43.24–44.17 52W close$43.54–86.50 Avg vol 30d3.8M Short int20.9M · 12.6% float · 5.2d Short vol33% Last earningsJul 29, 2026 DataJan 2020–Oct 2026 Filing10-Q · Jul 29

Up next

Next earnings call
Oct 28, 2026 Est · unconfirmed · in 4 wks
filed Jul 29, 2026
call held Jul 29, 2026

Metrics snapshot

Useful current figures from the complete screener profile.

Revenue (TTM)
$874.09M
Trailing 12 months
Net income (TTM)
−$565.17M
Trailing 12 months
Revenue growth YoY
-40.7%
Year over year
Operating margin
-68.0%
Trailing 12 months
P / E (TTM)
—
Trailing earnings
FCF yield
-7.6%
TTM · current market cap
Return on invested capital
—
Trailing 12 months
Net cash
—
Latest balance sheet
Dividend yield
—
Trailing 12 months
Shares change YoY
-9.3%
Year over year · fewer shares
Price change (1Y)
-33.1%
Trailing year
Short interest
12.6%
Latest settlement · 5.2 days to cover
View all 115 metrics

Equibles Rating

blended score · not investment advice
Overall
Sell
SellHoldBuy
Technical Sell Momentum Very Weak Sentiment Very Bullish Fundamentals Strong Quant / Vol Very High
Market backdrop VIX 15.3 · calm Equity put/call 0.58
Technical
price trend
Sell
50 / 200-day cross No cross
Price vs 200-day avg −38%
below
Price vs 50-day avg −19%
below
RSI (14) 30
neutral
MACD trend Positive
52-week position 0%
near low
Volume (OBV) Confirms
volume backs price
Momentum
relative strength
Very Weak
1-month return −25%
trailing
6-month return −42%
trailing
YTD return −45%
this year
Relative strength −54%
vs S&P · 6-mo
Sentiment
smart money
Very Bullish
Trend (MA cross) No cross
50d $54 › 200d $70 — 200d above 50d
Institutional flow Accumulating
3 of 522 funds reported for Sep 30 · net +387 sh shares
Insider flow Accumulating
Net +$1.1M over 90 days · 0% sells
Short interest Falling
12.57% of float · ▼ -0.2% MoM · 5.2 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
522 holders — near 3-yr high, broad support
Squeeze score 52
elevated · 0–100
Fundamentals
Strong
Revenue growth +46%
Y/Y
EPS growth +22%
Y/Y
Free cash flow $-320.0M
Buyback $125.0M
authorized
Balance sheet $441.9M
net debt
Quant / Vol
risk profile
Very High
Volatility 42%
annualized · 1-yr
Max drawdown −50%
past year
ATR 4.8%
of price · 14-day

Blended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.

Guidance & track record

Beat or met 3 of last 3
Latest guidance · from the Earnings Call filed Jun 30, 2026
full-year 2026
Full-year revenue Initiated $875M – $900M
prior FY $943.71M midpoint −6.0% Y/Y
Full-year Tringolza product sales Initiated $100M – $110M
Full-year Donzera product sales Initiated $110M – $120M
full-year 2026 year-end
2026 year-end cash balance at least $1.6B
Guided vs delivered · last 3 settled
Revenue Full Year 2024
guided at least $575M
$705.14M In line
Revenue 2021
guided at least $600M
$810.46M In line
Revenue 2020
guided at least $700M
$729.26M In line

Guidance from company 8-Ks · delivered figures from as-reported statements · no analyst estimates involved.

Technicals

trend & momentum for long-term holders Sell
3 · 3 · 1
50 / 200-day cross
No cross Neutral
Price vs 200-day avg
−38% Bearish
Price vs 50-day avg
−19% Bearish
RSI (14)
30 Neutral
MACD trend
Positive Bullish
52-week position
0% Bearish
Volume (OBV)
Confirms Neutral
Market signals — smart money & positioning
Bullish · 4 of 6
Trend (MA cross) No cross
50d $54 › 200d $70 — 200d above 50d
Institutional flow Accumulating
3 of 522 funds reported for Sep 30 · net +387 sh shares
Insider flow Accumulating
Net +$1.1M over 90 days · 0% sells
Short interest Falling
12.57% of float · ▼ -0.2% MoM · 5.2 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
522 holders — near 3-yr high, broad support
Price context
position in its 52-week range
Range low $44 Now $44 · 0% Range high $87
vs 200-day avg -38% vs 50-day avg -19%

Illustrative technical + ownership context — a signal mix, not investment advice.

Key metrics

Earlier KPI extraction records exist, but do not meet the current evidence-completeness requirements. No current verified series is available. Earlier figures remain withheld until revalidated; this is not evidence that the company reports no KPIs.

Versus peers

Biotechnology — same industry group
Open screener →
Company Mkt cap YTD Rev growth Y/Y P/E Short % shares
IONS
Ionis Pharmaceuticals Inc
this stock
$7.40B -45.0% +46.5% — 12.6%
VRTX
Vertex Pharmaceuticals Inc / Ma
$133.37B +11.3% +46.2% 30.7 1.9%
REGN
Regeneron Pharmaceuticals, Inc.
$81.13B -4.8% +20.8% 19.5 2.5%
MRNA
Moderna, Inc.
$79.40B +544.3% +4.3% — 8.2%
CSLLY
Csl Ltd
$61.25B — — — 0.0%

Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding

At a glance

key data from every section
Ownership
Institutional Holders Accumulating
Holders
522
% held
112.5%
Reported
3 of 522
Top holder
FMR LLC
Held Float
View
Held by Funds
Fund positions
477
View
Short & Settlement
Short Interest Falling
Shares short
20.9M
Days to cover
5.2d
Change
-34.4K sh
View
Short Volume
Short vol %
33%
As of
Oct 2, 2026
Short Total
View
Fails to Deliver
FTD shares
6.0K
Value
$334.7K
As of
Sep 10, 2026
View
Off-Exchange
Off-exchange %
42.7%
Week of
Aug 24, 2026
Off-exch Lit
View
Smart Money
Insider Trades Net buying
Net (90d)
+$1.1M
Buyers / Sellers
1 / 0
Buyers Sellers
View
Congressional Trades Sell
Member
Daniel Goldman
Amount
$1.0K–$15.0K
Traded
Mar 6, 2023
View
Financials
Financials
Revenue (FY)
$943.7M
Net income (FY)
$-381.4M
EPS diluted
$-2.38
View
Buybacks
Authorized
$125.0M
View
Filings
SEC Filings
Latest
8-K
Filed
Sep 23, 2026
This year
21
View
Proposed Sales
Value
$5.7M
Shares
67.4K
Filed
Jul 7, 2026
View
Earnings & Events
Webcasts
Last webcast
Jul 29, 2026
View

Performance

5D 20D 120D MTD YTD
IONS -2.2% -25.1% -41.9% -2.5% -45.0%
SPY -0.2% -0.5% +12.2% +0.9% +12.9%
vs SPY -1.9% -24.6% -54.1% -3.4% -57.8%

Capital returns

Buyback program · as of Sep 30, 2019
Authorized
$125.00M
Spent (derived)
—
Remaining
—

Dividends per share over the trailing 365 days by ex-date · buyback figures as last reported in SEC filings ("spent" derived as authorized − remaining; when several programs run concurrently, authorized is their combined total per the newest filing) · components shown separately — trailing-year buyback spend isn't tracked, so no combined shareholder yield is derived.

Key facts CIK 874015 CUSIP 462222100 13F (30d) 14 filings 12 filers Visit website Investor relations