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VRTX · Vertex Pharmaceuticals Inc / Ma

Track VRTX — free
$504.73 -2.01 (-0.40%) At close · Oct 2
Market Cap
$133.37B
Shares
253.46M
Volume · Oct 2 939.66K Avg daily vol (3M) 1.21M

Price & Indicators

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20d MA 50d MA 200d MA Earnings Filing Insider Congress Investor day
Close$504.73 Open$509.50 Day$499.95–509.50 52W close$402.90–557.96 Avg vol 30d995K Short int4.7M · 1.9% float · 5.0d Short vol58% Last earningsAug 3, 2026 DataJan 2020–Oct 2026 Filing10-Q · Aug 4

Up next

Next earnings call
Nov 2, 2026 Est · unconfirmed · in 4 wks
filed Aug 4, 2026
call held Aug 3, 2026

Metrics snapshot

Useful current figures from the complete screener profile.

Revenue (TTM)
$12.59B
Trailing 12 months
Net income (TTM)
$4.41B
Trailing 12 months
Revenue growth YoY
+12.5%
Year over year
Operating margin
38.0%
Trailing 12 months
P / E (TTM)
29.4
Trailing earnings · reciprocal yield 3.4%
FCF yield
2.8%
TTM · current market cap
Return on invested capital
—
Trailing 12 months
Net cash
—
Latest balance sheet
Dividend yield
—
Trailing 12 months
Shares change YoY
-1.4%
Year over year · fewer shares
Price change (1Y)
+23.5%
Trailing year
Short interest
1.9%
Latest settlement · 5.0 days to cover
View all 115 metrics

AI Brief

Q2 FY26 earnings call · Aug 3, 2026
Q2 FY26

TL;DR. Vertex raised full-year 2026 revenue guidance to $13.1–$13.2 billion on 12% Q2 revenue growth, while CASGEVY surged 78% sequentially with a record pediatric FDA approval and JOURNAVX quadrupled year-over-year on expanding payer coverage.

Bullish
  • + Raised full-year 2026 total revenue guidance to $13.1–$13.2 billion from $12.95–$13.1 billion
  • + CASGEVY Q2 revenue grew 78% sequentially to $76 million with FDA pediatric approval in record 53 days
  • + Povetacicept BLA accepted with November 30 PDUFA, supported by best-in-class Phase 3 RAINIER results
  • + Announced $8.8B Crinetics acquisition adding a fifth pillar in rare endocrine with ~$5B peak sales opportunity
Bearish
  • − Non-GAAP operating expenses now expected at high end of $5.65–$5.75B range due to commercial investment in launches
  • − Gross margin expected to step down in second half due to product mix and manufacturing investments
  • − JOURNAVX gross-to-net normalization delayed to first half of 2027 as PSP utilization exceeds forecast

AI-generated from the earnings call and 8-K · may contain errors · not investment advice

Equibles Rating

blended score · not investment advice
Overall
Buy
SellHoldBuy
Technical Neutral Momentum Strong Sentiment Neutral Fundamentals Excellent Quant / Vol Moderate
Market backdrop VIX 15.3 · calm Equity put/call 0.58
Technical
price trend
Neutral
50 / 200-day cross No cross
Price vs 200-day avg +7%
above
Price vs 50-day avg −3%
below
RSI (14) 39
neutral
MACD trend Negative
52-week position 66%
mid-range
Volume (OBV) Confirms
volume backs price
Momentum
relative strength
Strong
1-month return −10%
trailing
6-month return +15%
trailing
YTD return +11%
this year
Relative strength +3%
vs S&P · 6-mo
Sentiment
smart money
Neutral
Trend (MA cross) No cross
50d $518 › 200d $474 — 50d above 200d
Institutional flow Accumulating
8 of 1,771 funds reported for Sep 30 · net +252 sh shares
Insider flow Flat
No net insider activity over 90 days
Short interest Rising
1.86% of float · ▲ +1.2% MoM · 5.0 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
1,771 holders — near 3-yr high, broad support
Squeeze score 51
elevated · 0–100
Fundamentals
Excellent
Revenue growth +46%
Y/Y
EPS growth +837%
Y/Y
Free cash flow $3.2B
Valuation P/E 30.7
rich
Buyback $2.6B
remaining
Quant / Vol
risk profile
Moderate
Volatility 29%
annualized · 1-yr
Max drawdown −15%
past year
ATR 2.4%
of price · 14-day

Blended from price, momentum, positioning, fundamentals & volatility · daily-close · not investment advice. Market backdrop is context, not part of the score.

Guidance & track record

Beat or met 4 of last 4
Latest guidance · from the 8-K filed Aug 3, 2026
Total revenue · Full Year 2026 Initiated $13.1B – $13.2B
prior FY $12B midpoint +9.6% Y/Y
Combined GAAP R&D, AIPR&D and SG&A expenses · Full Year 2026 Initiated $6.3B – $6.45B
Combined non-GAAP R&D, AIPR&D and SG&A expenses · Full Year 2026 Initiated $5.65B – $5.75B
Guided vs delivered · last 4 settled
Total product revenues FY 2024
guided $10.55B – $10.75B
$11.02B Beat +3.5%
Revenue guidance 2022
guided $8.4B – $8.6B
$8.93B Beat +5.1%
Total product revenues for 2021
guided $7.4B – $7.5B
$7.57B Beat +1.7%
Total product revenues 2020
guided $6B – $6.2B
$6.21B Beat +1.7%

Guidance from company 8-Ks · delivered figures from as-reported statements · no analyst estimates involved.

Technicals

trend & momentum for long-term holders Neutral
1 · 5 · 1
50 / 200-day cross
No cross Neutral
Price vs 200-day avg
+7% Bullish
Price vs 50-day avg
−3% Neutral
RSI (14)
39 Neutral
MACD trend
Negative Bearish
52-week position
66% Neutral
Volume (OBV)
Confirms Neutral
Market signals — smart money & positioning
Bullish · 2 of 6
Trend (MA cross) No cross
50d $518 › 200d $474 — 50d above 200d
Institutional flow Accumulating
8 of 1,771 funds reported for Sep 30 · net +252 sh shares
Insider flow Flat
No net insider activity over 90 days
Short interest Rising
1.86% of float · ▲ +1.2% MoM · 5.0 days cover
Volume signal Normal
Volume near normal
Institution breadth Multi-yr high
1,771 holders — near 3-yr high, broad support
Price context
position in its 52-week range
Range low $403 Now $505 · 66% Range high $558
vs 200-day avg +7% vs 50-day avg -3%

Illustrative technical + ownership context — a signal mix, not investment advice.

Key metrics

Earlier KPI extraction records exist, but do not meet the current evidence-completeness requirements. No current verified series is available. Earlier figures remain withheld until revalidated; this is not evidence that the company reports no KPIs.

Versus peers

Biotechnology — same industry group
Open screener →
Company Mkt cap YTD Rev growth Y/Y P/E Short % shares
VRTX
Vertex Pharmaceuticals Inc / Ma
this stock
$133.37B +11.3% +46.2% 30.7 1.9%
REGN
Regeneron Pharmaceuticals, Inc.
$81.13B -4.8% +20.8% 19.5 2.5%
MRNA
Moderna, Inc.
$79.40B +544.3% +4.3% — 8.2%
CSLLY
Csl Ltd
$61.25B — — — 0.0%
ARGX
Argenx SE
$60.40B +9.3% — — 2.1%

Peers by industry group · P/E from as-reported trailing EPS · short % is of shares outstanding

At a glance

key data from every section
Ownership
Institutional Holders Accumulating
Holders
1,771
% held
96.4%
Reported
8 of 1,771
Top holder
Capital World Investors
Held Float
View
Held by Funds
Fund positions
1,168
View
Short & Settlement
Short Interest Rising
Shares short
4.7M
Days to cover
5.0d
Change
+57.1K sh
View
Short Volume
Short vol %
58%
As of
Oct 2, 2026
Short Total
View
Fails to Deliver
FTD shares
3
Value
$1.6K
As of
Aug 31, 2026
View
Off-Exchange
Off-exchange %
39.6%
Week of
Aug 24, 2026
Off-exch Lit
View
Smart Money
Congressional Trades Sell
Member
David J. Taylor
Amount
$1.0K–$15.0K
Traded
Aug 26, 2026
View
Financials
Financials
Revenue (FY)
$12.0B
Net income (FY)
$4.0B
EPS diluted
$15.32
View
Buybacks
Authorized
$4.0B
Remaining
$2.6B
Spent Remaining
View
Filings
SEC Filings
Latest
Investor Event Transcript
Filed
Sep 9, 2026
This year
19
View
Proposed Sales
Value
$799.8K
Shares
1.5K
Filed
Jul 2, 2026
View
Earnings & Events
Webcasts
Last webcast
Sep 9, 2026
View
Investor Relations
Latest news
Vertex Announces Positive Results…
Published
Sep 22, 2026
View

Performance

5D 20D 120D MTD YTD
VRTX -4.1% -9.5% +14.7% -3.5% +11.3%
SPY -0.2% -0.5% +12.2% +0.9% +12.9%
vs SPY -3.9% -9.1% +2.5% -4.4% -1.5%

Capital returns

Buyback program · as of Jun 30, 2026
Authorized
$4.00B
Spent (derived)
$1.40B
Remaining
$2.60B
Spent Remaining

Dividends per share over the trailing 365 days by ex-date · buyback figures as last reported in SEC filings ("spent" derived as authorized − remaining; when several programs run concurrently, authorized is their combined total per the newest filing) · components shown separately — trailing-year buyback spend isn't tracked, so no combined shareholder yield is derived.

Key facts CIK 875320 CUSIP 92532F100 13F (30d) 44 filings 26 filers Visit website Investor relations