INSM · INSMED Inc · Holdings

$95.67 +0.38 (+0.40%)

Russell 1000 member Rebalance outlook locked

Market Cap

$20.81B

218.38M

Volume · Oct 20 2.6M Avg daily vol (3M) 2.61M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of INSM: 13F, 13D and 13G, insiders and funds →

Institutional holdings are being reconciled with SEC filings. Holder totals and changes may be incomplete until reconciliation finishes.

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 679

Total Value: $24,868,087,836

Total Shares: 233,141,230

Showing 1–100 of 725 holdings by value · page 1 of 8

Institutional Ownership Trend

27 quarters

Superinvestors Holding INSM

All superinvestors →

Stanley Druckenmiller $295,837,447 Ray Dalio $48,553,895 Joel Greenblatt $2,334,231

Holder Concentration

Across 671 13F filers

Top Holder

7.0%

of institutional value

Top 5

27.0%

of institutional value

Top 10

42.4%

of institutional value

HHI

255

Broadly held

Who Holds INSM

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 668 filers, like-for-like change +0.6%; actively managed books +0.9%; index-like books -0.5%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	40.0%	337	+13.8%	69	73
Exempt adviser	4.0%	10	-48.5%	3	0
Adviser	8.6%	18	0.0%	3	3
Bank	11.0%	27	-35.6%	0	2
Insurer	0.5%	4	-6.1%	0	0
Broker-dealer	0.1%	3	+7.8%	0	0
Benefit plan	0.3%	7	-3.1%	0	0
Non-US	3.8%	16	+29.4%	0	2
Holding company	16.4%	13	+7.2%	0	0
Unknown	15.4%	233	+34.5%	36	41

Style	Share	Filers	Change	New	Exited
Index-like	24.5%	67	-0.5%	1	2
Systematic-like	8.2%	50	+74.0%	21	3
Concentrated	9.4%	107	-28.3%	27	37
Diversified active	57.9%	444	+1.6%	62	79
Not measured	0.0%	0	—	0	0
Unknown	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	49.6%	344	-8.0%	31	68
Medium turnover	24.5%	168	-8.0%	24	31
High turnover	12.3%	90	+92.5%	43	16
Unknown	13.6%	66	+9.9%	13	6
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	16.0%	97	-17.9%	36	11
Medium horizon	12.3%	130	+5.8%	19	31
Long horizon	61.9%	377	-3.6%	35	69
Unknown	9.8%	64	+136.8%	21	10
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	1.9%	174	+60.9%	53	42
$1B to $10B	10.5%	215	-23.1%	40	52
$10B to $100B	22.7%	194	+27.4%	17	26
$100B or more	65.0%	85	-2.9%	1	1
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	0.9%	158	+7.8%	28	50
Pooled investment vehicles	17.6%	85	+39.4%	34	13
Registered funds and BDCs	15.0%	39	+0.5%	3	5
Pension and profit sharing plans	0.0%	3	-64.3%	0	0
Insurance companies	0.1%	3	-42.1%	0	1
Charitable organizations	0.0%	2	+90.5%	0	0
Governments and sovereign funds	0.7%	12	+59.8%	2	0
Corporations	0.0%	2	-40.2%	0	0
Other investment advisers	0.0%	7	-20.4%	0	1
Other	0.0%	1	0.0%	0	0
Diversified	5.8%	24	-7.2%	2	3
Unknown	60.0%	332	-6.8%	42	48

Private funds	Share	Filers	Change	New	Exited
Hedge funds	26.2%	108	+4.5%	36	13
Private equity funds	0.7%	14	+9.3%	1	5
Venture capital funds	0.3%	2	+6.9%	0	0
Real estate funds	0.0%	4	-7.8%	0	2
Liquidity funds	0.0%	1	-79.0%	0	1
Securitized asset funds	0.6%	1	+9.9%	0	0
Other private funds	3.2%	24	+1.0%	3	4
Mixed private funds	0.2%	5	-31.5%	1	0
Private funds, type not stated	0.1%	11	+49.9%	4	2
No private funds	12.6%	177	-0.8%	27	46
Unknown	56.0%	321	-1.0%	39	48

Location	Share	Filers	Change	New	Exited
United States	82.5%	507	+0.9%	96	104
Outside the US	17.5%	161	-1.1%	15	16
Unknown	0.0%	0	-100.0%	0	1

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 7 holders with no observed 2026-03-31 13F and 5 holders with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Conviction and Crowding

668 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

2.40% of filers hold it in their top 10

Mar 31, 2026: 27

Holders above 5%

median weight 0.015%

Mar 31, 2026: 12

Crowding

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Private-fund advisers

—

of shares outstanding

Institutional ownership

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Top 10 holders

43.9%

of 13F shares, Herfindahl 0.027

Active holders

+0.9%

like-for-like share change of active filers

5% stakes on record

0 13D, 6 13G (5 institutional, 0 passive, 0 exempt)

How long holders have held it value-weighted 15.0 quarters

Under 1 year 20.0% 1 to 3 years 29.4% 3 years or more 50.6% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net sellers of $19,071,420 (0 buying, 1 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$101.72

estimated per share

Mar 31, 2026: $93.09

Quarter-end price

$106.60

implied by 13F values

Estimated gain or loss

+4.8%

price against the estimated cost

Estimated at a loss

46.8%

of costed 13F value

Estimated cost covers 38.8% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies INSM's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	ELVN Enliven Therapeutics, Inc.	24	0.334
2	XENE Xenon Pharmaceuticals Inc.	23	0.303
3	PCVX Vaxcyte, Inc.	20	0.294
4	NAMS NewAmsterdam Pharma Co N.V.	17	0.287
5	RVMD Revolution Medicines, Inc.	34	0.271
6	COGT Cogent Biosciences, Inc.	22	0.269
7	BBIO BridgeBio Pharma, Inc.	22	0.269
8	VERA Vera Therapeutics, Inc.	17	0.265
9	CYTK Cytokinetics Inc	25	0.264
10	RARE Ultragenyx Pharmaceutical Inc.	16	0.263

Shareholder Targets

13F filers that own its peers but not INSM, quarter ended Jun 30, 2026

Found through its holder-overlap peers: ELVN, XENE, PCVX, NAMS, RVMD, COGT, BBIO, VERA, CYTK, RARE, RYTM, CLDX, PRAX, SYRE, ASND, PTGX, MDGL, ALKS, CRNX, BLTE. 696 filers in all.

#	Filer	In peers	Of book	Largest peers
1	RA CAPITAL MANAGEMENT, L.P. Registered adviser, Concentrated	$4,480,297,262 4 held	39.5%	ASND, RYTM, PCVX
2	FARALLON CAPITAL MANAGEMENT LLC Registered adviser, Diversified active	$4,453,215,250 5 held	26.3%	RVMD, BBIO, PTGX
3	Avoro Capital Advisors LLC Registered adviser, Concentrated	$3,798,134,406 6 held	34.1%	ASND, MDGL, RVMD
4	PERCEPTIVE ADVISORS LLC Registered adviser, Diversified active	$1,886,510,132 7 held	30.4%	PRAX, SYRE, ASND
5	Capital World Investors Adviser, Diversified active	$1,710,263,472 7 held	0.200%	RVMD, NAMS, ASND
6	DEERFIELD MANAGEMENT COMPANY, L.P. Registered adviser, Diversified active	$1,431,326,244 7 held	24.3%	RVMD, PRAX, COGT
7	Nextech Invest, Ltd. Exempt adviser, Concentrated	$1,423,531,573 1 held	67.8%	RVMD
8	Driehaus Capital Management LLC Registered adviser, Diversified active	$1,361,128,398 11 held	7.91%	PRAX, XENE, SYRE
9	MASSACHUSETTS FINANCIAL SERVICES CO /MA/ Registered adviser, Diversified active	$1,008,475,430 6 held	0.340%	ASND, RVMD, CYTK
10	Kohlberg Kravis Roberts & Co. L.P. Registered adviser, Concentrated	$987,677,120 1 held	17.9%	BBIO

Fund Ownership of INSM by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 15.97% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	2.53%	+0.33 pp	5,530,160	78
Index ETFs	13.44%	+0.39 pp	29,342,548	112
Active ETFs	0.51%	-0.12 pp	1,107,078	55
Active funds	18.44%	-1.60 pp	40,267,149	380
Unclassified	3.43%	+1.32 pp	7,484,427	34
All registered funds	38.34%	+0.32 pp	83,731,362	659

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 343 Exempt adviser 10 Adviser 18 Bank 27 Insurer 4 Broker-dealer 3 Benefit plan 7 Non-US 16 Holding company 13 Unknown 238

Showing 100 of 725

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$1,721,228,815

6.92%

16,143,583

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC joint	11,695,604	$1,246,985,297	72.4%	Defined
FIDELITY MANAGEMENT TRUST CO	1,001,003	$106,726,939	6.2%	Defined
STRATEGIC ADVISERS LLC	861,325	$91,834,471	5.3%	Defined
Fidelity Institutional Asset Management Trust Co	91,015	$9,704,019	0.6%	Defined
FIAM LLC	2,493,120	$265,816,454	15.4%	Defined
Fidelity Diversifying Solutions LLC	1,516	$161,635	0.0%	Defined

BlackRock, Inc.

$1,685,447,245

6.78%

15,807,984

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	461,493	$49,204,383	2.9%	Sole
BlackRock Investment Management (Australia) Ltd	154,786	$16,503,283	1.0%	Sole
BlackRock Asset Management Canada Ltd	37,613	$4,010,298	0.2%	Sole
BLACKROCK (SINGAPORE) LTD.	21,760	$2,320,051	0.1%	Sole
BlackRock Asset Management North Asia Ltd	22,584	$2,407,906	0.1%	Sole
BlackRock Investment Management, LLC	246,765	$26,310,084	1.6%	Sole
BLACKROCK ADVISORS LLC	493,831	$52,652,261	3.1%	Sole
BlackRock Fund Advisors	5,964,311	$635,914,838	37.7%	Sole
BlackRock Institutional Trust Company, N.A.	5,512,213	$587,712,150	34.9%	Sole
BlackRock Japan Co. Ltd	248,269	$26,470,440	1.6%	Sole
BlackRock Fund Managers Ltd.	239,685	$25,555,214	1.5%	Sole
BlackRock Investment Management (UK) Ltd.	262,329	$27,969,517	1.7%	Sole
BlackRock (Netherlands) B.V.	321,929	$34,324,069	2.0%	Sole
BlackRock International, Ltd.	168	$17,912	0.0%	Sole
BlackRock Asset Management Ireland Ltd	1,111,910	$118,551,844	7.0%	Sole
BlackRock Advisors (UK) Ltd	11,146	$1,188,386	0.1%	Sole
BlackRock (Luxembourg) S.A.	437,499	$46,646,143	2.8%	Sole
BlackRock Life Ltd	56,335	$6,006,437	0.4%	Sole
BlackRock Asset Management Schweiz AG	8,185	$872,684	0.1%	Sole
Aperio Group, LLC	184,350	$19,655,397	1.2%	Sole
SpiderRock Advisors, LLC	10,823	$1,153,948	0.1%	Sole

JPMORGAN CHASE & CO

$1,111,851,478

4.47%

10,428,170

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	2,389	$254,714	0.0%	Other
JPMorgan Chase Bank, N.A.	998,372	$106,446,422	9.6%	Other
J.P. Morgan Investment Management Inc.	8,261,679	$880,860,214	79.2%	Other
J.P. Morgan Securities LLC	491,553	$52,409,380	4.7%	Defined
J.P. Morgan Securities plc	63,168	$6,734,972	0.6%	Defined
JPMorgan Asset Management (UK) Ltd	446,432	$47,598,579	4.3%	Defined
JPMorgan Asset Management (Canada) Inc.	13,713	$1,462,080	0.1%	Defined
J.P. Morgan (Suisse) SA	8,281	$882,920	0.1%	Other
JPMorgan Asset Management (Asia Pacific) Ltd	12,621	$1,345,651	0.1%	Defined
JPMorgan Asset Management (Japan) Ltd	109,630	$11,688,750	1.1%	Defined
55I, LLC	108	$11,514	0.0%	Other
J.P. Morgan SE	20,224	$2,156,282	0.2%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$1,109,696,908

4.46%

10,407,962

VANGUARD CAPITAL MANAGEMENT LLC

$1,043,902,026

4.20%

9,790,865

BAKER BROS. ADVISORS LP

$937,841,354

3.77%

8,796,111

Capital International Investors

$878,348,780

3.53%

8,238,124

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	8,238,124	$878,348,780	100.0%	Defined

Darwin Global Management, Ltd.

$685,690,599

2.76%

6,431,163

AMERIPRISE FINANCIAL INC

$658,865,856

2.65%

6,179,571

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC joint	4,837,696	$515,795,146	78.3%	Defined
Ameriprise Trust Co	15,239	$1,624,782	0.2%	Defined
Threadneedle Asset Management Holdings LTD	995,704	$106,161,960	16.1%	Defined
Ameriprise Financial Services, LLC	756	$80,604	0.0%	Defined
Ameriprise Bank, FSB	270	$28,787	0.0%	Defined
Columbia Threadneedle Management Ltd	329,906	$35,174,577	5.3%	Defined

Orbis Allan Gray Ltd

$647,875,043

2.61%

6,076,487

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ORBIS INVESTMENT MANAGEMENT LTD	6,070,702	$647,258,247	99.9%	Defined
Held directly	5,785	$616,796	0.1%	Defined

STATE STREET CORP

$645,282,791

2.59%

6,052,174

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS (JAPAN) CO., LTD. joint	6,052,174	$645,282,791	100.0%	Defined

D. E. Shaw & Co., Inc.

$626,707,987

2.52%

5,877,959

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	4,750,037	$506,448,944	80.8%	Defined
D. E. Shaw Investment Management, L.L.C. joint	1,127,922	$120,259,043	19.2%	Defined

Artisan Partners Limited Partnership

$580,195,973

2.33%

5,441,718

RTW INVESTMENTS, LP

$516,347,865

2.08%

4,842,880

GEODE CAPITAL MANAGEMENT, LLC

$449,952,925

1.81%

4,220,155

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	558,369	$59,533,302	13.2%	Defined
Held directly	3,661,786	$390,419,623	86.8%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$363,072,019

1.46%

3,405,290

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	232,115	$24,748,101	6.8%	Defined
Held directly	3,173,175	$338,323,918	93.2%	Sole

NORGES BANK

$360,124,083

1.45%

3,377,641

Jupiter Topco LLC

$277,764,397

1.12%

2,605,181

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	12,349	$1,316,650	0.5%	Defined
JANUS HENDERSON INVESTORS US LLC	2,579,765	$275,054,544	99.0%	Defined
Held directly	13,067	$1,393,203	0.5%	Defined

UBS Group AG

$275,553,630

1.11%

2,584,446

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	35,890	$3,826,591	1.4%	Defined
UBS AG	2,533,973	$270,172,201	98.0%	Defined
UBS Switzerland AG	7,332	$781,737	0.3%	Defined
UBS Bank (Canada)	7,251	$773,101	0.3%	Defined

CITADEL ADVISORS LLC

$272,624,460

1.10%

2,556,973

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	1,050,815	$112,037,895	41.1%	Defined
Held directly	1,506,158	$160,586,565	58.9%	Defined

FRANKLIN RESOURCES INC

$242,370,927

0.97%

2,273,222

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST CO INTERNATIONAL	210	$22,390	0.0%	Defined
Fiduciary Trust Co International of Pennsylvania	7,500	$799,650	0.3%	Defined
Fiduciary Trust International of the South	98	$10,448	0.0%	Defined
FIDUCIARY TRUST INTERNATIONAL LLC	4,702	$501,327	0.2%	Defined
FRANKLIN ADVISERS INC	1,752,657	$186,868,289	77.1%	Defined
FRANKLIN ADVISORY SERVICES LLC	8,588	$915,652	0.4%	Defined
PUTNAM INVESTMENT MANAGEMENT LLC	483,891	$51,592,458	21.3%	Defined
PUTNAM ADVISORY CO LLC	15,576	$1,660,713	0.7%	Defined

MAVERICK CAPITAL LTD

$229,314,244

0.92%

2,150,762

MILLENNIUM MANAGEMENT LLC

$218,358,293

0.88%

2,048,005

Qube Research & Technologies Ltd

$179,370,451

0.72%

1,682,334

WESTFIELD CAPITAL MANAGEMENT CO LP

$173,743,793

0.70%

1,629,561

T. Rowe Price Investment Management, Inc.

$173,009,608

0.70%

1,622,675

Integral Health Asset Management, LLC

$170,592,000

0.69%

1,600,000

Duquesne Family Office LLC

$151,900,447

0.61%

1,424,690

GOLDMAN SACHS GROUP INC

$150,321,937

0.60%

1,409,885

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	725,052	$77,305,044	51.4%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	672,497	$71,701,630	47.7%	Defined
GOLDMAN SACHS INTERNATIONAL	6,591	$702,732	0.5%	Defined
GOLDMAN SACHS WEALTH SERVICES, L.P.	3,585	$382,232	0.3%	Defined
Goldman Sachs Trust Company, N.A.	2,160	$230,299	0.2%	Defined

VANGUARD FIDUCIARY TRUST CO

$149,433,474

0.60%

1,401,552

Bellevue Group AG

$148,566,226

0.60%

1,393,418

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	1,381,740	$147,321,118	99.2%	Defined
Bellevue Asset Management AG	11,678	$1,245,108	0.8%	Defined

Assenagon Asset Management S.A.

$144,591,182

0.58%

1,266,788

Duquesne Family Office LLC

$143,937,000

0.58%

1,350,000

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$142,345,265

0.57%

1,335,071

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	119,481	$12,739,064	8.9%	Defined
UBS Asset Management Switzerland AG	602,973	$64,288,980	45.2%	Defined
UBS Asset Management (UK) Ltd.	374,235	$39,900,934	28.0%	Defined
UBS Asset Management Life Ltd.	3,135	$334,253	0.2%	Defined
Held directly	235,247	$25,082,034	17.6%	Defined

Balyasny Asset Management L.P.

$141,423,966

0.57%

1,326,430

Paradigm Biocapital Advisors LP

$141,375,667

0.57%

1,325,977

NORTHERN TRUST CORP

$140,239,949

0.56%

1,315,325

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	1,039,548	$110,836,607	79.0%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	234,338	$24,985,117	17.8%	Defined
Northern Trust Asset Management Australia Pty Ltd	40,059	$4,271,090	3.0%	Defined
Northern Trust Co of Hong Kong Ltd	1,380	$147,135	0.1%	Defined

Bank of New York Mellon Corp

$139,966,036

0.56%

1,312,756

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNY Mellon Trust of Delaware joint	712	$75,913	0.1%	Defined
Mellon Investments Corporation joint	395,365	$42,153,815	30.1%	Defined
Newton Investment Management Limited joint	285,249	$30,413,247	21.7%	Defined
BNY Mellon Securities Corporation	1,279	$136,366	0.1%	Defined
The Bank of New York Mellon	186,257	$19,858,721	14.2%	Defined
BNY Mellon, NA joint	57,629	$6,144,402	4.4%	Defined
BNY Mellon Advisors, Inc. joint	15,620	$1,665,404	1.2%	Other
Newton Investment Management North America, LLC joint	370,643	$39,517,955	28.2%	Defined
Held directly	2	$213	0.0%	Defined

TWO SIGMA INVESTMENTS, LP

$132,445,709

0.53%

1,242,222

MORGAN STANLEY

$131,515,551

0.53%

1,233,498

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	1,881	$200,552	0.2%	Defined
MORGAN STANLEY & CO. LLC	76,010	$8,104,186	6.2%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	487,982	$52,028,640	39.6%	Defined
MORGAN STANLEY AIP GP LP	81	$8,636	0.0%	Defined
MORGAN STANLEY INVESTMENT MANAGEMENT INC	12,858	$1,370,919	1.0%	Defined
MORGAN STANLEY SMITH BARNEY LLC	105,135	$11,209,493	8.5%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	422,393	$45,035,540	34.2%	Defined
EATON VANCE MANAGEMENT	26,836	$2,861,254	2.2%	Defined
Calvert Research & Management	65,283	$6,960,473	5.3%	Defined
BOSTON MANAGEMENT & RESEARCH	35,039	$3,735,858	2.8%	Defined

Pictet Asset Management Holding SA

$130,114,036

0.52%

1,220,353

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$129,432,735

0.52%

1,213,963

Hood River Capital Management LLC

$112,683,586

0.45%

1,056,871

BANK OF AMERICA CORP /DE/

$109,084,412

0.44%

1,023,114

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	310,600	$33,116,172	30.4%	Defined
MERRILL LYNCH, PIERCE, FENNER & SMITH INC.	67,538	$7,200,901	6.6%	Defined
BOFA SECURITIES, INC.	89,643	$9,557,736	8.8%	Defined
MERRILL LYNCH INTERNATIONAL	27,628	$2,945,697	2.7%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	527,705	$56,263,906	51.6%	Defined

SEI INVESTMENTS CO

$108,312,059

0.44%

1,015,870

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	16,294	$1,737,266	1.6%	Sole
SEI TRUST CO	999,576	$106,574,793	98.4%	Sole

NWI MANAGEMENT LP

$108,112,680

0.43%

1,014,000

Castle Hook Partners LP

$105,906,712

0.43%

993,310

JENNISON ASSOCIATES LLC

$96,501,122

0.39%

905,094

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prudential Financial Inc	905,094	$96,501,122	100.0%	Defined

Polar Capital Holdings Plc

$94,984,772

0.38%

890,872

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	890,872	$94,984,772	100.0%	Defined

MILLENNIUM MANAGEMENT LLC

$92,119,680

0.37%

864,000

FIL Ltd

$91,289,536

0.37%

856,214

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIL Investments International	856,214	$91,289,536	100.0%	Defined

PRINCIPAL FINANCIAL GROUP INC

$91,280,154

0.37%

856,126

ADAGE CAPITAL PARTNERS GP, L.L.C.

$90,627,000

0.36%

850,000

Fiera Capital Corp

$89,885,137

0.36%

843,042

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fiera Capital Inc.	594,166	$63,349,978	70.5%	Other
Held directly	248,876	$26,535,159	29.5%	Sole

Legal & General Group Plc

$88,114,072

0.35%

826,431

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	160,880	$17,153,025	19.5%	Defined
Legal & General Investment Management Ltd joint	665,551	$70,961,047	80.5%	Defined

FRONTIER CAPITAL MANAGEMENT CO LLC

$84,788,702

0.34%

795,242

GOLDMAN SACHS GROUP INC

$81,873,498

0.33%

767,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	767,900	$81,873,498	100.0%	Defined

AMERICAN CENTURY COMPANIES INC

$81,002,945

0.33%

759,735

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	759,735	$81,002,945	100.0%	Defined

Caption Management, LLC

$78,973,434

0.32%

740,700

SAMLYN CAPITAL, LLC

$78,106,398

0.31%

732,568

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SAMLYN ONSHORE FUND, LP joint	118,137	$12,595,766	16.1%	Defined
Samlyn Offshore Master Fund, Ltd.	279,617	$29,812,764	38.2%	Defined
Samlyn Net Neutral Master Fund, Ltd.	260,270	$27,749,987	35.5%	Defined
Samlyn Long Alpha Master Fund, Ltd.	74,544	$7,947,881	10.2%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$77,763,723

0.31%

729,354

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	729,354	$77,763,723	100.0%	Other

TimesSquare Capital Management, LLC

$77,629,595

0.31%

728,096

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$76,670,442

0.31%

719,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	719,100	$76,670,442	100.0%	Other

Clearbridge Investments, LLC

$76,331,603

0.31%

715,922

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$76,297,272

0.31%

715,600

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	715,600	$76,297,272	100.0%	Other

Ensign Peak Advisors, Inc

$74,948,635

0.30%

702,951

DEUTSCHE BANK AG\

$73,630,703

0.30%

690,590

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deutsche Bank Trust Co Americas	1,818	$193,835	0.3%	Defined
DWS Investment GmbH	141,141	$15,048,453	20.4%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	28,784	$3,068,950	4.2%	Defined
DWS Investments UK Ltd	452,531	$48,248,855	65.5%	Defined
DBX Advisors LLC	1,953	$208,228	0.3%	Defined
DWS Investments Hong Kong Ltd	10,470	$1,116,311	1.5%	Defined
DWS International GmbH	53,893	$5,746,071	7.8%	Defined

HRT FINANCIAL LP

$73,565,774

0.30%

689,981

RAYMOND JAMES FINANCIAL INC

$70,433,276

0.28%

660,601

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	115,844	$12,351,287	17.5%	Defined
Raymond James Financial Services Advisors, Inc.	3,992	$425,627	0.6%	Defined
ClariVest Asset Management LLC joint	12,117	$1,291,914	1.8%	Defined
EAGLE ASSET MANAGEMENT INC joint	528,648	$56,364,448	80.0%	Defined

Affinity Asset Advisors, LLC

$69,303,000

0.28%

650,000

Caption Management, LLC

$67,170,600

0.27%

630,000

WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC

$67,152,581

0.27%

629,831

GW&K Investment Management, LLC

$67,145,010

0.27%

629,760

Squarepoint Ops LLC

$65,727,391

0.26%

616,464

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	616,464	$65,727,391	100.0%	Defined

AQR CAPITAL MANAGEMENT LLC

$65,340,145

0.26%

612,832

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
KEB ASSET MANAGEMENT, LLC	2	$213	0.0%	Other
Compound Planning, Inc.	3	$319	0.0%	Other
Arax Advisory Partners	183	$19,511	0.0%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	42	$4,478	0.0%	Other
Stokes Family Office, LLC	6	$639	0.0%	Other
Held directly	612,596	$65,314,985	100.0%	Defined

Railway Pension Investments Ltd

$64,473,114

0.26%

604,700

Swiss National Bank

$63,280,249

0.25%

593,512

Nuveen, LLC

$63,102,405

0.25%

591,844

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	51,391	$5,479,307	8.7%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	220,683	$23,529,221	37.3%	Defined
TEACHERS ADVISORS, LLC joint	319,770	$34,093,877	54.0%	Defined

Artia Global Partners LP

$62,804,724

0.25%

589,052

EVENTIDE ASSET MANAGEMENT, LLC

$62,230,362

0.25%

583,665

Aberdeen Group plc

$61,566,331

0.25%

577,437

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	565,545	$60,298,407	97.9%	Defined
abrdn Investment Management Ltd	749	$79,858	0.1%	Defined
abrdn Investments Ltd	11,143	$1,188,066	1.9%	Defined

Davern Capital Partners, LP

$59,688,434

0.24%

559,824

Candriam S.C.A.

$59,188,067

0.24%

555,131

WELLINGTON MANAGEMENT GROUP LLP

$57,989,869

0.23%

543,893

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	445,457	$47,494,625	81.9%	Defined
Wellington Managment Canada LLC	9,971	$1,063,108	1.8%	Defined
Wellington Management Hong Kong Ltd	13,896	$1,481,591	2.6%	Defined
Wellington Management Singapore Pte. Ltd.	800	$85,296	0.1%	Defined
Wellington Management International Ltd	2,239	$238,722	0.4%	Defined
Wellington Trust Company, NA joint	67,582	$7,205,592	12.4%	Defined
Wellington Management Australia Pty Ltd	3,948	$420,935	0.7%	Defined

Point72 Asset Management, L.P.

$57,254,620

0.23%

536,997

Long Focus Capital Management, LLC

$56,295,360

0.23%

528,000

MARSHALL WACE, LLP

$53,515,775

0.22%

501,930

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	501,930	$53,515,775	100.0%	Other

Amundi

$51,979,914

0.21%

487,525

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Amundi Asset Management joint	487,525	$51,979,914	100.0%	Defined

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$50,677,231

0.20%

475,307

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	39,569	$4,218,846	8.3%	Defined
BNP Paribas Asset Management USA, Inc.	176,989	$18,870,567	37.2%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	258,749	$27,587,818	54.4%	Defined

ALLIANCEBERNSTEIN L.P.

$49,343,309

0.20%

462,796

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	462,796	$49,343,309	100.0%	Defined

Bridgewater Associates, LP

$48,553,895

0.20%

455,392

JANE STREET GROUP, LLC

$48,160,254

0.19%

451,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	451,700	$48,160,254	100.0%	Defined

Sumitomo Mitsui Trust Group, Inc.

$46,668,960

0.19%

437,713

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUMITOMO MITSUI TRUST BANK Ltd joint	437,713	$46,668,960	100.0%	Defined

ROYAL BANK OF CANADA

$44,405,840

0.18%

416,487

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC Global Asset Management Inc.	185,561	$19,784,513	44.6%	Defined
RBC Capital Markets, LLC	184,841	$19,707,747	44.4%	Defined
RBC Dominion Securities Inc.	32,835	$3,500,867	7.9%	Defined
RBC Phillips, Hager & North Investment Counsel Inc.	2,584	$275,506	0.6%	Defined
RBC Private Counsel (USA) Inc.	303	$32,305	0.1%	Defined
RBC Trust Co (Delaware) Ltd	347	$36,997	0.1%	Defined
CITY NATIONAL BANK	34	$3,625	0.0%	Defined
RBC Rochdale, LLC	1,109	$118,241	0.3%	Defined
Held directly	8,873	$946,039	2.1%	Sole

VANGUARD ASSET MANAGEMENT, Ltd

$44,365,434

0.18%

416,108

Palo Alto Investors LP

$44,138,547

0.18%

413,980

DIMENSIONAL FUND ADVISORS LP

$43,542,326

0.18%

408,388

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	7,988	$851,680	2.0%	Defined
DFA Australia Ltd.	38,562	$4,111,480	9.4%	Defined
Dimensional Fund Advisors Pte. Ltd.	1,522	$162,275	0.4%	Defined
Dimensional Ireland Ltd	33,755	$3,598,958	8.3%	Defined
Held directly	326,561	$34,817,933	80.0%	Sole

BNP PARIBAS ARBITRAGE, SA

$42,729,564

0.17%

400,765

GATEWAY INVESTMENT ADVISERS LLC

$41,702,190

0.17%

365,360

Eagle Health Investments LP

$40,955,940

0.16%

384,130

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Key facts CIK 1104506 CUSIP 457669307 13F (30d) 87 filings 82 filers Visit website Investor relations