XENE · Xenon Pharmaceuticals Inc. · Holdings

$36.27 +1.19 (+3.39%)

Russell 2000 member Rebalance outlook locked

Market Cap

$3.51B

96.84M

Volume · Oct 20 979.71K Avg daily vol (3M) 1.42M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of XENE: 13F, 13D and 13G, insiders and funds →

Institutional holdings are being reconciled with SEC filings. Holder totals and changes may be incomplete until reconciliation finishes.

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 317

Total Value: $6,170,525,166

Total Shares: 102,262,287

Showing 1–100 of 322 holdings by value · page 1 of 4

Institutional Ownership Trend

27 quarters

Superinvestors Holding XENE

All superinvestors →

Stanley Druckenmiller $14,401,896

Holder Concentration

Across 318 13F filers

Top Holder

9.4%

of institutional value

Top 5

31.3%

of institutional value

Top 10

45.5%

of institutional value

HHI

302

Broadly held

Who Holds XENE

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 315 filers, like-for-like change +0.9%; actively managed books -2.6%; index-like books +24.0%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	46.9%	158	-2.1%	32	10
Exempt adviser	0.8%	5	+150.0%	2	3
Adviser	9.1%	12	+19.7%	1	1
Bank	6.4%	17	+20.3%	0	0
Insurer	0.1%	3	+186.1%	1	0
Broker-dealer	0.0%	1	-81.7%	0	1
Benefit plan	0.4%	5	+2.0%	0	0
Non-US	2.0%	10	-15.1%	1	0
Holding company	20.4%	10	-12.3%	0	0
Unknown	13.8%	94	+17.3%	9	7

Style	Share	Filers	Change	New	Exited
Index-like	16.2%	34	+24.0%	0	0
Systematic-like	7.4%	34	+8.7%	9	3
Concentrated	9.6%	44	-8.6%	11	3
Diversified active	66.7%	203	-2.8%	26	16
Not measured	0.0%	0	—	0	0
Unknown	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	50.0%	144	+11.7%	15	7
Medium turnover	34.2%	89	-10.0%	11	5
High turnover	9.5%	53	-11.4%	14	10
Unknown	6.3%	29	+11.9%	6	0
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	7.0%	50	+8.0%	12	5
Medium horizon	21.3%	50	+12.5%	7	8
Long horizon	56.2%	182	-2.7%	21	5
Unknown	15.5%	33	-2.7%	6	4
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	3.4%	56	+0.7%	10	5
$1B to $10B	14.6%	89	-13.1%	19	11
$10B to $100B	27.4%	96	-2.5%	16	5
$100B or more	54.6%	74	+7.4%	1	1
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	0.4%	50	+28.4%	17	4
Pooled investment vehicles	28.3%	57	-11.9%	9	3
Registered funds and BDCs	6.3%	17	+30.2%	2	1
Pension and profit sharing plans	0.0%	2	+678.3%	1	0
Insurance companies	0.1%	3	+16.7%	0	0
Governments and sovereign funds	2.2%	8	+56.6%	1	0
Other investment advisers	0.0%	3	+1.4%	0	0
Other	0.0%	1	-60.0%	0	1
Diversified	9.5%	16	+4.9%	1	0
Corporations	0.0%	0	—	0	0
Unknown	53.1%	158	+3.8%	15	13

Private funds	Share	Filers	Change	New	Exited
Hedge funds	29.2%	63	-7.2%	11	7
Private equity funds	0.6%	10	+4.2%	2	0
Venture capital funds	0.4%	2	0.0%	0	0
Real estate funds	0.0%	2	+1.5%	1	1
Securitized asset funds	0.4%	1	-0.1%	0	0
Other private funds	6.1%	15	+16.2%	3	1
Mixed private funds	7.4%	4	+2.2%	0	0
Private funds, type not stated	0.0%	3	-64.5%	1	1
No private funds	3.6%	62	+25.1%	15	3
Unknown	52.3%	153	+2.8%	13	9

Location	Share	Filers	Change	New	Exited
United States	88.0%	250	0.0%	38	18
Outside the US	12.0%	65	+8.1%	8	4

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 2 holders with no observed 2026-03-31 13F and 1 holder with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Conviction and Crowding

315 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

3.81% of filers hold it in their top 10

Mar 31, 2026: 13

Holders above 5%

median weight 0.007%

Mar 31, 2026: 5

Crowding

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Private-fund advisers

—

of shares outstanding

Institutional ownership

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Top 10 holders

46.0%

of 13F shares, Herfindahl 0.031

Active holders

-2.6%

like-for-like share change of active filers

5% stakes on record

0 13D, 3 13G (3 institutional, 0 passive, 0 exempt)

How long holders have held it value-weighted 14.9 quarters

Under 1 year 17.0% 1 to 3 years 28.1% 3 years or more 54.9% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net sellers of $388,652 (0 buying, 1 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$43.80

estimated per share

Mar 31, 2026: $40.06

Quarter-end price

$60.36

implied by 13F values

Estimated gain or loss

+37.8%

price against the estimated cost

Estimated at a loss

0.000%

of costed 13F value

Estimated cost covers 52.9% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies XENE's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	ELVN Enliven Therapeutics, Inc.	24	0.454
2	GPCR Structure Therapeutics Inc.	21	0.405
3	DNTH Dianthus Therapeutics, Inc. /DE/	22	0.404
4	RYTM Rhythm Pharmaceuticals, Inc.	20	0.394
5	CLDX Celldex Therapeutics, Inc.	19	0.374
6	PHVS Pharvaris N.V.	17	0.364
7	STOK Stoke Therapeutics, Inc.	13	0.355
8	EWTX Edgewise Therapeutics, Inc.	16	0.352
9	SYRE Spyre Therapeutics, Inc.	19	0.349
10	COGT Cogent Biosciences, Inc.	21	0.348

Shareholder Targets

13F filers that own its peers but not XENE, quarter ended Jun 30, 2026

Found through its holder-overlap peers: ELVN, GPCR, DNTH, RYTM, CLDX, PHVS, STOK, EWTX, SYRE, COGT, CYTK, MLYS, SNDX, PRAX, RVMD, MIRM, AVTX, MBX, TRVI, SION. 839 filers in all.

#	Filer	In peers	Of book	Largest peers
1	FARALLON CAPITAL MANAGEMENT LLC Registered adviser, Diversified active	$2,584,614,014 3 held	15.3%	RVMD, AVTX, COGT
2	Paradigm Biocapital Advisors LP Registered adviser, Concentrated	$2,085,829,205 4 held	45.3%	RVMD, EWTX, SYRE
3	Darwin Global Management, Ltd. Exempt adviser, Concentrated	$1,990,753,064 1 held	51.4%	RVMD
4	RA CAPITAL MANAGEMENT, L.P. Registered adviser, Concentrated	$1,780,261,971 6 held	15.7%	RYTM, SION, EWTX
5	PERCEPTIVE ADVISORS LLC Registered adviser, Diversified active	$1,690,860,221 9 held	27.3%	PRAX, SYRE, RYTM
6	Frazier Life Sciences Management, L.P. Registered adviser, Concentrated	$1,550,432,500 4 held	33.8%	MIRM, MBX, TRVI
7	Nextech Invest, Ltd. Exempt adviser, Concentrated	$1,423,531,573 1 held	67.8%	RVMD
8	RTW INVESTMENTS, LP Registered adviser, Diversified active	$1,008,357,170 7 held	8.61%	SYRE, CYTK, STOK
9	BVF INC/IL Unknown, Concentrated	$981,353,770 5 held	27.4%	RVMD, GPCR, MIRM
10	TCG Crossover Management, LLC Unknown, Diversified active	$834,716,224 8 held	20.1%	COGT, SYRE, DNTH

Fund Ownership of XENE by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 7.51% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	2.10%	+0.51 pp	2,036,529	39
Index ETFs	5.40%	+0.81 pp	5,233,504	30
Active ETFs	0.37%	+0.23 pp	361,047	19
Active funds	32.55%	+7.80 pp	31,525,320	224
Unclassified	0.23%	+0.23 pp	227,120	13
All registered funds	40.67%	+9.57 pp	39,383,520	325

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 159 Exempt adviser 6 Adviser 12 Bank 17 Insurer 3 Broker-dealer 1 Benefit plan 5 Non-US 10 Holding company 10 Unknown 94

Showing 100 of 322

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$582,353,157

9.44%

9,647,998

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	6,847,190	$413,296,388	71.0%	Defined
FIDELITY MANAGEMENT TRUST CO	130,001	$7,846,860	1.3%	Defined
STRATEGIC ADVISERS LLC	13	$784	0.0%	Defined
Fidelity Institutional Asset Management Trust Co	508,650	$30,702,114	5.3%	Defined
FIAM LLC	2,162,144	$130,507,011	22.4%	Defined

BlackRock, Inc.

$454,057,006

7.36%

7,522,482

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	145,555	$8,785,699	1.9%	Sole
BlackRock Investment Management (Australia) Ltd	197	$11,890	0.0%	Sole
BlackRock Asset Management Canada Ltd	20,739	$1,251,806	0.3%	Sole
BlackRock Investment Management, LLC	298,817	$18,036,594	4.0%	Sole
BLACKROCK ADVISORS LLC	558,512	$33,711,784	7.4%	Sole
BlackRock Fund Advisors	4,275,142	$258,047,571	56.8%	Sole
BlackRock Institutional Trust Company, N.A.	1,636,089	$98,754,332	21.7%	Sole
BlackRock Japan Co. Ltd	5,333	$321,899	0.1%	Sole
BlackRock Fund Managers Ltd.	15,785	$952,782	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	50,796	$3,066,046	0.7%	Sole
BlackRock Asset Management Ireland Ltd	418,715	$25,273,637	5.6%	Sole
BlackRock (Luxembourg) S.A.	4,901	$295,824	0.1%	Sole
BlackRock Life Ltd	230	$13,882	0.0%	Sole
BlackRock Asset Management Schweiz AG	13,291	$802,244	0.2%	Sole
Aperio Group, LLC	78,380	$4,731,016	1.0%	Sole

Avoro Capital Advisors LLC

$348,746,619

5.65%

5,777,777

Polar Capital Holdings Plc

$275,878,760

4.47%

4,570,556

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	4,570,556	$275,878,760	100.0%	Defined

Driehaus Capital Management LLC

$266,704,100

4.32%

4,418,557

Jupiter Topco LLC

$252,698,286

4.10%

4,186,519

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	42,309	$2,553,771	1.0%	Defined
JANUS HENDERSON INVESTORS US LLC	4,136,909	$249,703,827	98.8%	Defined
Held directly	7,301	$440,688	0.2%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$196,062,498

3.18%

3,248,219

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	80,665	$4,868,939	2.5%	Defined
Held directly	3,167,554	$191,193,559	97.5%	Sole

JPMORGAN CHASE & CO

$157,983,846

2.56%

2,617,360

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	478	$28,851	0.0%	Other
JPMorgan Chase Bank, N.A.	81,780	$4,936,240	3.1%	Defined
J.P. Morgan Investment Management Inc.	2,277,460	$137,467,485	87.0%	Defined
J.P. Morgan Securities LLC	707	$42,674	0.0%	Defined
J.P. Morgan Securities plc	7,242	$437,127	0.3%	Defined
JPMorgan Asset Management (UK) Ltd	249,693	$15,071,469	9.5%	Defined

Capital International Investors

$142,548,530

2.31%

2,361,639

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	2,361,639	$142,548,530	100.0%	Defined

T. Rowe Price Investment Management, Inc.

$130,895,549

2.12%

2,168,581

STATE STREET CORP

$118,886,806

1.93%

1,969,629

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	1,969,629	$118,886,806	100.0%	Defined

TWO SIGMA INVESTMENTS, LP

$99,162,305

1.61%

1,642,848

DEERFIELD MANAGEMENT COMPANY, L.P.

$97,523,410

1.58%

1,615,696

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	1,615,696	$97,523,410	100.0%	Defined

Affinity Asset Advisors, LLC

$96,274,200

1.56%

1,595,000

ALLIANCEBERNSTEIN L.P.

$94,298,979

1.53%

1,562,276

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	1,562,276	$94,298,979	100.0%	Defined

WESTFIELD CAPITAL MANAGEMENT CO LP

$90,980,265

1.47%

1,507,294

FRANKLIN RESOURCES INC

$86,780,295

1.41%

1,437,712

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	1,681	$101,465	0.1%	Defined
FRANKLIN ADVISERS INC	614,993	$37,120,977	42.8%	Defined
PUTNAM INVESTMENT MANAGEMENT LLC	568,914	$34,339,649	39.6%	Defined
PUTNAM ADVISORY CO LLC	252,124	$15,218,204	17.5%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$86,042,693

1.39%

1,425,492

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	1,015,092	$61,270,953	71.2%	Defined
Wellington Managment Canada LLC	29,399	$1,774,523	2.1%	Defined
Wellington Management Singapore Pte. Ltd.	40,472	$2,442,889	2.8%	Defined
Wellington Management International Ltd	30,655	$1,850,335	2.2%	Defined
Wellington Trust Company, NA joint	303,267	$18,305,196	21.3%	Defined
Wellington Management Australia Pty Ltd	4,552	$274,758	0.3%	Defined
Wellington Management Europe GmbH	2,055	$124,039	0.1%	Defined

CITADEL ADVISORS LLC

$84,578,966

1.37%

1,401,242

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	394,795	$23,829,826	28.2%	Defined
Held directly	1,006,447	$60,749,140	71.8%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$82,700,080

1.34%

1,370,114

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	141,317	$8,529,894	10.3%	Defined
Held directly	1,228,797	$74,170,186	89.7%	Defined

Siren, L.L.C.

$79,588,523

1.29%

1,318,564

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	1,318,564	$79,588,523	100.0%	Defined

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$77,908,522

1.26%

1,290,731

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	1,554	$93,799	0.1%	Defined
BNP Paribas Asset Management USA, Inc.	1,154,365	$69,677,471	89.4%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	134,812	$8,137,252	10.4%	Defined

Pictet Asset Management Holding SA

$71,690,960

1.16%

1,187,723

BRAIDWELL LP

$68,294,442

1.11%

1,131,452

Nuveen, LLC

$59,945,084

0.97%

993,126

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	30,832	$1,861,019	3.1%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	287,148	$17,332,253	28.9%	Defined
TEACHERS ADVISORS, LLC joint	675,146	$40,751,812	68.0%	Defined

Invesco Ltd.

$54,532,721

0.88%

903,458

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	851,652	$51,405,712	94.3%	Defined
Invesco Trust Co joint	38,896	$2,347,762	4.3%	Defined
Invesco Capital Management LLC	12,910	$779,247	1.4%	Defined

ORBIMED ADVISORS LLC

$53,869,549

0.87%

892,471

Caligan Partners LP

$53,717,019

0.87%

889,944

AMERICAN CENTURY COMPANIES INC

$53,377,494

0.87%

884,319

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	884,319	$53,377,494	100.0%	Defined

FEDERATED HERMES, INC.

$53,342,365

0.86%

883,737

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED GLOBAL INVESTMENT MANAGEMENT CORP	883,737	$53,342,365	100.0%	Defined

Capital World Investors

$52,077,099

0.84%

862,775

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	862,775	$52,077,099	100.0%	Defined

GOLDMAN SACHS GROUP INC

$46,696,002

0.76%

773,625

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	363,745	$21,955,648	47.0%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	401,111	$24,211,059	51.8%	Defined
GOLDMAN SACHS INTERNATIONAL	4,761	$287,373	0.6%	Defined
Goldman Sachs Trust Company, N.A.	4,008	$241,922	0.5%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$45,248,934

0.73%

749,651

Caption Management, LLC

$43,942,080

0.71%

728,000

Vestal Point Capital, LP

$42,252,000

0.68%

700,000

Alyeska Investment Group, L.P.

$42,112,689

0.68%

697,692

MARSHALL WACE, LLP

$41,608,682

0.67%

689,342

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	689,342	$41,608,682	100.0%	Other

Rock Springs Capital Management LP

$41,280,626

0.67%

683,907

NORTHERN TRUST CORP

$40,535,720

0.66%

671,566

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	601,131	$36,284,266	89.5%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	55,202	$3,331,991	8.2%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	15,233	$919,463	2.3%	Other

PANAGORA ASSET MANAGEMENT INC

$40,080,911

0.65%

664,031

First Turn Management, LLC

$36,228,072

0.59%

600,200

TUDOR INVESTMENT CORP ET AL

$32,919,559

0.53%

545,387

LOOMIS SAYLES & CO L P

$31,826,198

0.52%

527,273

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
LOOMIS SAYLES TRUST COMPANY, LLC	88,806	$5,360,330	16.8%	Defined
Held directly	438,467	$26,465,868	83.2%	Defined

Octagon Capital Advisors LP

$29,576,400

0.48%

490,000

NOVO HOLDINGS A/S

$29,301,037

0.47%

485,438

Candriam S.C.A.

$27,932,676

0.45%

462,768

TimesSquare Capital Management, LLC

$27,258,153

0.44%

451,593

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GuideStone Capital Management, LLC joint	451,593	$27,258,153	100.0%	Sole

Logos Global Management LP

$27,162,000

0.44%

450,000

Trails Edge Capital Partners, LP

$26,558,400

0.43%

440,000

Bank of New York Mellon Corp

$25,442,821

0.41%

421,518

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	85,851	$5,181,966	20.4%	Defined
BNY Mellon Securities Corporation	5,020	$303,007	1.2%	Defined
The Bank of New York Mellon	153,202	$9,247,272	36.3%	Defined
BNY Mellon, NA joint	1,145	$69,112	0.3%	Defined
BNY Mellon Advisors, Inc. joint	3,442	$207,758	0.8%	Defined
Newton Investment Management North America, LLC joint	172,856	$10,433,586	41.0%	Defined
Held directly	2	$120	0.0%	Defined

ALGERT GLOBAL LLC

$25,337,498

0.41%

419,773

Aberdeen Group plc

$24,671,304

0.40%

408,736

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	408,736	$24,671,304	100.0%	Defined

MORGAN STANLEY

$24,521,669

0.40%

406,257

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	1,556	$93,920	0.4%	Defined
MORGAN STANLEY & CO. LLC	38,469	$2,321,988	9.5%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	62,473	$3,770,870	15.4%	Defined
MORGAN STANLEY SMITH BARNEY LLC	3,722	$224,659	0.9%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	199,888	$12,065,239	49.2%	Defined
Eaton Vance Advisers International Ltd	100,149	$6,044,993	24.7%	Defined

Fiera Capital Corp

$24,484,308

0.40%

405,638

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fiera Capital Inc.	397,086	$23,968,110	97.9%	Other
Held directly	8,552	$516,198	2.1%	Sole

BANK OF AMERICA CORP /DE/

$24,389,482

0.40%

404,067

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	152,537	$9,207,133	37.8%	Defined
BOFA SECURITIES, INC.	27,147	$1,638,592	6.7%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	224,383	$13,543,757	55.5%	Defined

Parkman Healthcare Partners LLC

$23,985,796

0.39%

397,379

Nicholas Investment Partners, LP

$23,893,143

0.39%

395,844

MILLENNIUM MANAGEMENT LLC

$22,742,259

0.37%

376,777

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$22,619,786

0.37%

374,748

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	1,732	$104,543	0.5%	Defined
UBS Asset Management Switzerland AG	314,689	$18,994,628	84.0%	Defined
UBS Asset Management (UK) Ltd.	45,429	$2,742,093	12.1%	Defined
Held directly	12,898	$778,522	3.4%	Defined

BAKER BROS. ADVISORS LP

$22,345,754

0.36%

370,208

Jones Hill Capital LP

$22,206,444

0.36%

367,900

AMERIPRISE FINANCIAL INC

$19,227,556

0.31%

318,548

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	304,358	$18,371,048	95.5%	Defined
Ameriprise Trust Co	14,131	$852,947	4.4%	Defined
Ameriprise Financial Services, LLC	59	$3,561	0.0%	Defined

Man Group plc

$18,748,841

0.30%

310,617

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AHL Partners LLP	38,111	$2,300,379	12.3%	Defined
Numeric Investors LLC	272,506	$16,448,462	87.7%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$18,108,000

0.29%

300,000

Soleus Capital Management, L.P.

$16,116,120

0.26%

267,000

Jump Financial, LLC

$15,737,662

0.26%

260,730

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jump Trading Holdings, LLC	1,430	$86,314	0.5%	Defined
Leap GP LLC joint	259,300	$15,651,348	99.5%	Defined

DAFNA Capital Management LLC

$15,136,597

0.25%

250,772

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$15,058,190

0.24%

249,473

STATE OF WISCONSIN INVESTMENT BOARD

$15,018,835

0.24%

248,821

NAN FUNG TRINITY (HK) LTD

$14,955,095

0.24%

247,765

Duquesne Family Office LLC

$14,401,896

0.23%

238,600

Allspring Global Investments Holdings, LLC

$14,149,107

0.23%

234,412

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Allspring Funds Management, LLC reporting on behalf of Morgan Stanley Smith Barney, LLC	6,450	$389,321	2.8%	Other
Allspring Global Investments, LLC reporting on behalf of UBS ASSET MANAGEMENT AMERICAS INC	227,962	$13,759,786	97.2%	Defined

Redmile Group, LLC

$13,845,014

0.22%

229,374

Schonfeld Strategic Advisors LLC

$13,721,638

0.22%

227,330

D. E. Shaw & Co., Inc.

$13,515,931

0.22%

223,922

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	223,922	$13,515,931	100.0%	Defined

Patient Square Capital LP

$13,279,200

0.22%

220,000

NEW YORK STATE COMMON RETIREMENT FUND

$12,704,029

0.21%

210,471

JENNISON ASSOCIATES LLC

$12,558,501

0.20%

208,060

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prudential Financial Inc	208,060	$12,558,501	100.0%	Defined

NEUBERGER BERMAN GROUP LLC

$12,470,616

0.20%

206,604

Trexquant Investment LP

$12,220,183

0.20%

202,455

DNB Asset Management AS

$12,099,222

0.20%

200,451

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DNB FUND	200,451	$12,099,222	100.0%	Other

Integral Health Asset Management, LLC

$12,072,000

0.20%

200,000

Eversept Partners, LP

$11,862,671

0.19%

196,532

Balyasny Asset Management L.P.

$11,674,045

0.19%

193,407

DEUTSCHE BANK AG\

$11,536,364

0.19%

191,126

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deutsche Bank Trust Co Americas	1,270	$76,657	0.7%	Defined
DWS Investment GmbH	88,188	$5,323,027	46.1%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	1,848	$111,545	1.0%	Defined
DWS Investments UK Ltd	99,820	$6,025,135	52.2%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$11,438,220

0.19%

189,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	189,500	$11,438,220	100.0%	Other

RENAISSANCE TECHNOLOGIES LLC

$11,293,959

0.18%

187,110

SILVERARC CAPITAL MANAGEMENT, LLC

$11,276,515

0.18%

186,821

BOOTHBAY FUND MANAGEMENT, LLC

$11,066,583

0.18%

183,343

NEXTBio Capital Management LP

$11,059,461

0.18%

183,225

WELLS FARGO & COMPANY/MN

$10,499,317

0.17%

173,945

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	89,433	$5,398,175	51.4%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	15,047	$908,236	8.7%	Defined
WELLS FARGO CLEARING SERVICES, LLC	69,316	$4,183,913	39.8%	Defined
Wells Fargo Securities, LLC	120	$7,243	0.1%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	29	$1,750	0.0%	Defined

ADAR1 Capital Management, LLC

$10,052,958

0.16%

166,550

PEREGRINE CAPITAL MANAGEMENT LLC

$9,953,001

0.16%

164,894

Swiss National Bank

$9,820,572

0.16%

162,700

Foresite Capital Management IV, LLC

$9,657,600

0.16%

160,000

Woodline Partners LP

$9,374,028

0.15%

155,302

Russell Investments Group, Ltd.

$9,248,779

0.15%

153,227

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	70,594	$4,261,053	46.1%	Defined
Russell Investments Capital, LLC	56,205	$3,392,533	36.7%	Defined
Russell Investments France SAS	6,466	$390,287	4.2%	Defined
Russell Investments Trust Company joint	19,962	$1,204,906	13.0%	Other

HSBC HOLDINGS PLC

$9,142,969

0.15%

151,474

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HSBC Global Asset Management (UK) Ltd	2,272	$137,137	1.5%	Defined
HSBC GLOBAL ASSET MANAGEMENT (FRANCE)	149,202	$9,005,832	98.5%	Defined

Susquehanna Portfolio Strategies, LLC

$8,031,441

0.13%

133,059

Point72 Asset Management, L.P.

$7,869,616

0.13%

130,378

Showing the top 100 of 322 holders. Create a free account to see every holder, past quarters, search, filters and CSV export.

Key facts CIK 1582313 CUSIP 98420N105 13F (30d) 15 filings 15 filers Visit website Investor relations