XENE · Xenon Pharmaceuticals Inc.

$59.99 -1.94 (-3.13%) At close · Aug 28

Russell 2000 member Rebalance outlook locked

Market Cap

$5.81B

96.84M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 317

Total Value: $6,165,198,025

Total Shares: 102,140,500

Showing 1–100 of 322 holdings by value · page 1 of 4

Institutional Ownership Trend

26 quarters

Superinvestors Holding XENE

All superinvestors →

Stanley Druckenmiller $14,401,896

Holder Concentration

Across 317 13F filers · Δ vs Mar 31, 2026

Top Holder

9.4%

−0.9 pts

Top 5

31.3%

+1.0 pts

Top 10

45.5%

−0.2 pts

HHI

303

Broadly held−3

Quarterly Activity

vs Mar 31, 2026

New

Increased

125

Decreased

Sold Out

Unchanged

Holder count: +22

Institutional value: +1.7%

Shares held: -2.0%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega PRICE T ROWE ASSOCIATES INC /MD/	+1,918,628	3,248,219
Mega BlackRock, Inc.	+1,882,364	7,522,482
Mega T. Rowe Price Investment Management, Inc.	+1,216,626	2,168,581
Mega TWO SIGMA INVESTMENTS, LP	+1,036,763	1,642,848
Mega Invesco Ltd.	+844,355	903,458

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mega WELLINGTON MANAGEMENT GROUP LLP	−3,404,149	1,425,492
Mega CITADEL ADVISORS LLC	−1,438,248	1,448,142
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP	−1,410,779	284,258
Mega FMR LLC	−1,170,493	9,647,998
Mega JENNISON ASSOCIATES LLC	−1,110,754	208,060

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Jupiter Topco LLC	4,186,519	$252,698,286
Large MARSHALL WACE, LLP	689,342	$41,608,682
Large PANAGORA ASSET MANAGEMENT INC	664,031	$40,080,911
Small Jones Hill Capital LP	367,900	$22,206,444
Large Man Group plc	310,617	$18,748,841

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega JANUS HENDERSON GROUP PLC	4,175,982	$242,833,352
Large Holocene Advisors, LP	1,518,686	$88,311,590
Mid Commodore Capital LP	825,000	$47,973,750
Mid MPM BIOIMPACT LLC	588,706	$34,233,253
Mid Sofinnova Investments, Inc.	305,216	$17,748,310

Filter: New 49 Increased 125 Reduced 90 Sold out 27 Unchanged 53

Showing 100 of 322

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$582,353,157

9.45%

9,647,998

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	6,847,190	$413,296,388	71.0%	Defined
FIDELITY MANAGEMENT TRUST CO	130,001	$7,846,860	1.3%	Defined
STRATEGIC ADVISERS LLC	13	$784	0.0%	Defined
Fidelity Institutional Asset Management Trust Co	508,650	$30,702,114	5.3%	Defined
FIAM LLC	2,162,144	$130,507,011	22.4%	Defined

BlackRock, Inc.

$454,057,006

7.36%

7,522,482

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	145,555	$8,785,699	1.9%	Sole
BlackRock Investment Management (Australia) Ltd	197	$11,890	0.0%	Sole
BlackRock Asset Management Canada Ltd	20,739	$1,251,806	0.3%	Sole
BlackRock Investment Management, LLC	298,817	$18,036,594	4.0%	Sole
BLACKROCK ADVISORS LLC	558,512	$33,711,784	7.4%	Sole
BlackRock Fund Advisors	4,275,142	$258,047,571	56.8%	Sole
BlackRock Institutional Trust Company, N.A.	1,636,089	$98,754,332	21.7%	Sole
BlackRock Japan Co. Ltd	5,333	$321,899	0.1%	Sole
BlackRock Fund Managers Ltd.	15,785	$952,782	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	50,796	$3,066,046	0.7%	Sole
BlackRock Asset Management Ireland Ltd	418,715	$25,273,637	5.6%	Sole
BlackRock (Luxembourg) S.A.	4,901	$295,824	0.1%	Sole
BlackRock Life Ltd	230	$13,882	0.0%	Sole
BlackRock Asset Management Schweiz AG	13,291	$802,244	0.2%	Sole
Aperio Group, LLC	78,380	$4,731,016	1.0%	Sole

Avoro Capital Advisors LLC

$348,746,619

5.66%

5,777,777

Polar Capital Holdings Plc

$275,878,760

4.47%

4,570,556

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	4,570,556	$275,878,760	100.0%	Defined

Driehaus Capital Management LLC

$266,704,100

4.33%

4,418,557

Jupiter Topco LLC

$252,698,286

4.10%

4,186,519

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	42,309	$2,553,771	1.0%	Defined
JANUS HENDERSON INVESTORS US LLC	4,136,909	$249,703,827	98.8%	Defined
Held directly	7,301	$440,688	0.2%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$196,062,498

3.18%

3,248,219

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	80,665	$4,868,939	2.5%	Defined
Held directly	3,167,554	$191,193,559	97.5%	Sole

JPMORGAN CHASE & CO

$157,983,846

2.56%

2,617,360

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	478	$28,851	0.0%	Other
JPMorgan Chase Bank, N.A.	81,780	$4,936,240	3.1%	Defined
J.P. Morgan Investment Management Inc.	2,277,460	$137,467,485	87.0%	Defined
J.P. Morgan Securities LLC	707	$42,674	0.0%	Defined
J.P. Morgan Securities plc	7,242	$437,127	0.3%	Defined
JPMorgan Asset Management (UK) Ltd	249,693	$15,071,469	9.5%	Defined

Capital International Investors

$142,548,530

2.31%

2,361,639

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	2,361,639	$142,548,530	100.0%	Defined

T. Rowe Price Investment Management, Inc.

$130,895,549

2.12%

2,168,581

STATE STREET CORP

$118,886,806

1.93%

1,969,629

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	1,969,629	$118,886,806	100.0%	Defined

TWO SIGMA INVESTMENTS, LP

$99,162,305

1.61%

1,642,848

DEERFIELD MANAGEMENT COMPANY, L.P.

$97,523,410

1.58%

1,615,696

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deerfield UGP, LLC	1,615,696	$97,523,410	100.0%	Defined

Affinity Asset Advisors, LLC

$96,274,200

1.56%

1,595,000

ALLIANCEBERNSTEIN L.P.

$94,298,979

1.53%

1,562,276

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	1,562,276	$94,298,979	100.0%	Defined

WESTFIELD CAPITAL MANAGEMENT CO LP

$90,980,265

1.48%

1,507,294

FRANKLIN RESOURCES INC

$86,780,295

1.41%

1,437,712

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	1,681	$101,465	0.1%	Defined
FRANKLIN ADVISERS INC	614,993	$37,120,977	42.8%	Defined
PUTNAM INVESTMENT MANAGEMENT LLC	568,914	$34,339,649	39.6%	Defined
PUTNAM ADVISORY CO LLC	252,124	$15,218,204	17.5%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$86,042,693

1.40%

1,425,492

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	1,015,092	$61,270,953	71.2%	Defined
Wellington Managment Canada LLC	29,399	$1,774,523	2.1%	Defined
Wellington Management Singapore Pte. Ltd.	40,472	$2,442,889	2.8%	Defined
Wellington Management International Ltd	30,655	$1,850,335	2.2%	Defined
Wellington Trust Company, NA joint	303,267	$18,305,196	21.3%	Defined
Wellington Management Australia Pty Ltd	4,552	$274,758	0.3%	Defined
Wellington Management Europe GmbH	2,055	$124,039	0.1%	Defined

CITADEL ADVISORS LLC

$84,578,966

1.37%

1,401,242

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	394,795	$23,829,826	28.2%	Defined
Held directly	1,006,447	$60,749,140	71.8%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$82,700,080

1.34%

1,370,114

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	141,317	$8,529,894	10.3%	Defined
Held directly	1,228,797	$74,170,186	89.7%	Defined

Siren, L.L.C.

$79,588,523

1.29%

1,318,564

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	1,318,564	$79,588,523	100.0%	Defined

BNP PARIBAS ASSET MANAGEMENT Holding S.A.

$77,908,522

1.26%

1,290,731

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	1,554	$93,799	0.1%	Defined
BNP Paribas Asset Management USA, Inc.	1,154,365	$69,677,471	89.4%	Defined
AXA INVESTMENT MANAGERS UK LIMITED	134,812	$8,137,252	10.4%	Defined

Pictet Asset Management Holding SA

$71,690,960

1.16%

1,187,723

BRAIDWELL LP

$68,294,442

1.11%

1,131,452

Nuveen, LLC

$59,945,084

0.97%

993,126

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	30,832	$1,861,019	3.1%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	287,148	$17,332,253	28.9%	Defined
TEACHERS ADVISORS, LLC joint	675,146	$40,751,812	68.0%	Defined

Invesco Ltd.

$54,532,721

0.88%

903,458

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	851,652	$51,405,712	94.3%	Defined
Invesco Trust Co joint	38,896	$2,347,762	4.3%	Defined
Invesco Capital Management LLC	12,910	$779,247	1.4%	Defined

ORBIMED ADVISORS LLC

$53,869,549

0.87%

892,471

Caligan Partners LP

$53,717,019

0.87%

889,944

AMERICAN CENTURY COMPANIES INC

$53,377,494

0.87%

884,319

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	884,319	$53,377,494	100.0%	Defined

FEDERATED HERMES, INC.

$53,342,365

0.87%

883,737

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED GLOBAL INVESTMENT MANAGEMENT CORP	883,737	$53,342,365	100.0%	Defined

Capital World Investors

$52,077,099

0.84%

862,775

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	862,775	$52,077,099	100.0%	Defined

GOLDMAN SACHS GROUP INC

$46,696,002

0.76%

773,625

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	363,745	$21,955,648	47.0%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	401,111	$24,211,059	51.8%	Defined
GOLDMAN SACHS INTERNATIONAL	4,761	$287,373	0.6%	Defined
Goldman Sachs Trust Company, N.A.	4,008	$241,922	0.5%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$45,248,934

0.73%

749,651

Caption Management, LLC

$43,942,080

0.71%

728,000

Vestal Point Capital, LP

$42,252,000

0.69%

700,000

Alyeska Investment Group, L.P.

$42,112,689

0.68%

697,692

MARSHALL WACE, LLP

$41,608,682

0.67%

689,342

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	689,342	$41,608,682	100.0%	Other

Rock Springs Capital Management LP

$41,280,626

0.67%

683,907

NORTHERN TRUST CORP

$40,535,720

0.66%

671,566

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	601,131	$36,284,266	89.5%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	55,202	$3,331,991	8.2%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	15,233	$919,463	2.3%	Other

PANAGORA ASSET MANAGEMENT INC

$40,080,911

0.65%

664,031

First Turn Management, LLC

$36,228,072

0.59%

600,200

TUDOR INVESTMENT CORP ET AL

$32,919,559

0.53%

545,387

LOOMIS SAYLES & CO L P

$31,826,198

0.52%

527,273

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
LOOMIS SAYLES TRUST COMPANY, LLC	88,806	$5,360,330	16.8%	Defined
Held directly	438,467	$26,465,868	83.2%	Defined

Octagon Capital Advisors LP

$29,576,400

0.48%

490,000

NOVO HOLDINGS A/S

$29,301,037

0.48%

485,438

Candriam S.C.A.

$27,932,676

0.45%

462,768

TimesSquare Capital Management, LLC

$27,258,153

0.44%

451,593

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GuideStone Capital Management, LLC joint	451,593	$27,258,153	100.0%	Sole

Logos Global Management LP

$27,162,000

0.44%

450,000

Trails Edge Capital Partners, LP

$26,558,400

0.43%

440,000

Bank of New York Mellon Corp

$25,442,821

0.41%

421,518

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	85,851	$5,181,966	20.4%	Defined
BNY Mellon Securities Corporation	5,020	$303,007	1.2%	Defined
The Bank of New York Mellon	153,202	$9,247,272	36.3%	Defined
BNY Mellon, NA joint	1,145	$69,112	0.3%	Defined
BNY Mellon Advisors, Inc. joint	3,442	$207,758	0.8%	Defined
Newton Investment Management North America, LLC joint	172,856	$10,433,586	41.0%	Defined
Held directly	2	$120	0.0%	Defined

ALGERT GLOBAL LLC

$25,337,498

0.41%

419,773

Aberdeen Group plc

$24,671,304

0.40%

408,736

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	408,736	$24,671,304	100.0%	Defined

MORGAN STANLEY

$24,521,669

0.40%

406,257

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	1,556	$93,920	0.4%	Defined
MORGAN STANLEY & CO. LLC	38,469	$2,321,988	9.5%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	62,473	$3,770,870	15.4%	Defined
MORGAN STANLEY SMITH BARNEY LLC	3,722	$224,659	0.9%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	199,888	$12,065,239	49.2%	Defined
Eaton Vance Advisers International Ltd	100,149	$6,044,993	24.7%	Defined

Fiera Capital Corp

$24,484,308

0.40%

405,638

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fiera Capital Inc.	397,086	$23,968,110	97.9%	Other
Held directly	8,552	$516,198	2.1%	Sole

BANK OF AMERICA CORP /DE/

$24,389,482

0.40%

404,067

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	152,537	$9,207,133	37.8%	Defined
BOFA SECURITIES, INC.	27,147	$1,638,592	6.7%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	224,383	$13,543,757	55.5%	Defined

Parkman Healthcare Partners LLC

$23,985,796

0.39%

397,379

Nicholas Investment Partners, LP

$23,893,143

0.39%

395,844

MILLENNIUM MANAGEMENT LLC

$22,742,259

0.37%

376,777

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$22,619,786

0.37%

374,748

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	1,732	$104,543	0.5%	Defined
UBS Asset Management Switzerland AG	314,689	$18,994,628	84.0%	Defined
UBS Asset Management (UK) Ltd.	45,429	$2,742,093	12.1%	Defined
Held directly	12,898	$778,522	3.4%	Defined

BAKER BROS. ADVISORS LP

$22,345,754

0.36%

370,208

Jones Hill Capital LP

$22,206,444

0.36%

367,900

AMERIPRISE FINANCIAL INC

$19,227,556

0.31%

318,548

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	304,358	$18,371,048	95.5%	Defined
Ameriprise Trust Co	14,131	$852,947	4.4%	Defined
Ameriprise Financial Services, LLC	59	$3,561	0.0%	Defined

Man Group plc

$18,748,841

0.30%

310,617

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AHL Partners LLP	38,111	$2,300,379	12.3%	Defined
Numeric Investors LLC	272,506	$16,448,462	87.7%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$18,108,000

0.29%

300,000

Soleus Capital Management, L.P.

$16,116,120

0.26%

267,000

Jump Financial, LLC

$15,737,662

0.26%

260,730

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jump Trading Holdings, LLC	1,430	$86,314	0.5%	Defined
Leap GP LLC joint	259,300	$15,651,348	99.5%	Defined

DAFNA Capital Management LLC

$15,136,597

0.25%

250,772

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$15,058,190

0.24%

249,473

STATE OF WISCONSIN INVESTMENT BOARD

$15,018,835

0.24%

248,821

NAN FUNG TRINITY (HK) LTD

$14,955,095

0.24%

247,765

Duquesne Family Office LLC

$14,401,896

0.23%

238,600

Allspring Global Investments Holdings, LLC

$14,149,107

0.23%

234,412

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Allspring Funds Management, LLC reporting on behalf of Morgan Stanley Smith Barney, LLC	6,450	$389,321	2.8%	Other
Allspring Global Investments, LLC reporting on behalf of UBS ASSET MANAGEMENT AMERICAS INC	227,962	$13,759,786	97.2%	Defined

Redmile Group, LLC

$13,845,014

0.22%

229,374

Schonfeld Strategic Advisors LLC

$13,721,638

0.22%

227,330

D. E. Shaw & Co., Inc.

$13,515,931

0.22%

223,922

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	223,922	$13,515,931	100.0%	Defined

Patient Square Capital LP

$13,279,200

0.22%

220,000

NEW YORK STATE COMMON RETIREMENT FUND

$12,704,029

0.21%

210,471

JENNISON ASSOCIATES LLC

$12,558,501

0.20%

208,060

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prudential Financial Inc	208,060	$12,558,501	100.0%	Defined

NEUBERGER BERMAN GROUP LLC

$12,470,616

0.20%

206,604

Trexquant Investment LP

$12,220,183

0.20%

202,455

DNB Asset Management AS

$12,099,222

0.20%

200,451

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DNB FUND	200,451	$12,099,222	100.0%	Other

Integral Health Asset Management, LLC

$12,072,000

0.20%

200,000

Eversept Partners, LP

$11,862,671

0.19%

196,532

Balyasny Asset Management L.P.

$11,674,045

0.19%

193,407

DEUTSCHE BANK AG\

$11,536,364

0.19%

191,126

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Deutsche Bank Trust Co Americas	1,270	$76,657	0.7%	Defined
DWS Investment GmbH	88,188	$5,323,027	46.1%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	1,848	$111,545	1.0%	Defined
DWS Investments UK Ltd	99,820	$6,025,135	52.2%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$11,438,220

0.19%

189,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	189,500	$11,438,220	100.0%	Other

RENAISSANCE TECHNOLOGIES LLC

$11,293,959

0.18%

187,110

SILVERARC CAPITAL MANAGEMENT, LLC

$11,276,515

0.18%

186,821

BOOTHBAY FUND MANAGEMENT, LLC

$11,066,583

0.18%

183,343

NEXTBio Capital Management LP

$11,059,461

0.18%

183,225

WELLS FARGO & COMPANY/MN

$10,499,317

0.17%

173,945

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	89,433	$5,398,175	51.4%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	15,047	$908,236	8.7%	Defined
WELLS FARGO CLEARING SERVICES, LLC	69,316	$4,183,913	39.8%	Defined
Wells Fargo Securities, LLC	120	$7,243	0.1%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	29	$1,750	0.0%	Defined

ADAR1 Capital Management, LLC

$10,052,958

0.16%

166,550

PEREGRINE CAPITAL MANAGEMENT LLC

$9,953,001

0.16%

164,894

Swiss National Bank

$9,820,572

0.16%

162,700

Foresite Capital Management IV, LLC

$9,657,600

0.16%

160,000

Woodline Partners LP

$9,374,028

0.15%

155,302

Russell Investments Group, Ltd.

$9,248,779

0.15%

153,227

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	70,594	$4,261,053	46.1%	Defined
Russell Investments Capital, LLC	56,205	$3,392,533	36.7%	Defined
Russell Investments France SAS	6,466	$390,287	4.2%	Defined
Russell Investments Trust Company joint	19,962	$1,204,906	13.0%	Other

HSBC HOLDINGS PLC

$9,142,969

0.15%

151,474

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HSBC Global Asset Management (UK) Ltd	2,272	$137,137	1.5%	Defined
HSBC GLOBAL ASSET MANAGEMENT (FRANCE)	149,202	$9,005,832	98.5%	Defined

Susquehanna Portfolio Strategies, LLC

$8,031,441

0.13%

133,059

Point72 Asset Management, L.P.

$7,869,616

0.13%

130,378

Key facts CIK 1582313 CUSIP 98420N105 13F (30d) 279 filings 266 filers Visit website Investor relations