SYRE · Spyre Therapeutics, Inc. · Holdings

$90.60 +1.89 (+2.13%) At close · Sep 11

Russell 2000 member Rebalance outlook locked

Market Cap

$7.99B

88.17M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 268

Total Value: $8,566,364,267

Total Shares: 96,489,813

Showing 1–100 of 276 holdings by value · page 1 of 3

Institutional Ownership Trend

12 quarters

Holder Concentration

Across 268 13F filers · Δ vs Mar 31, 2026

Top Holder

13.5%

−0.7 pts

Top 5

33.1%

−2.2 pts

Top 10

48.9%

−3.3 pts

HHI

397

Broadly held−41

Quarterly Activity

vs Mar 31, 2026

New

Increased

106

Decreased

Sold Out

Unchanged

Holder count: +68

Institutional value: +104.5%

Shares held: +16.2%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mid Paradigm Biocapital Advisors LP	+1,883,512	3,840,778
Mega VANGUARD PORTFOLIO MANAGEMENT LLC	+1,744,968	2,330,098
Mega Capital World Investors	+1,648,989	2,315,553
Mega PRICE T ROWE ASSOCIATES INC /MD/	+1,362,125	2,960,855
Mega FMR LLC	+1,245,163	13,026,187

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mid Commodore Capital LP	−1,065,594	846,786
Mega Capital International Investors	−790,933	955,196
Mid Venrock Adviser, LLC	−700,000	2,985,448
Mega WELLINGTON MANAGEMENT GROUP LLP	−243,306	1,581,505
Mid BOOTHBAY FUND MANAGEMENT, LLC	−186,578	6,453

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Jupiter Topco LLC	2,206,936	$195,931,777
Large ADAGE CAPITAL PARTNERS GP, L.L.C.	1,722,300	$152,905,794
Large Holocene Advisors, LP	1,015,170	$90,126,792
Mid Integral Health Asset Management, LLC	325,000	$28,853,500
Mega JENNISON ASSOCIATES LLC	303,180	$26,916,320

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mid Fairmount Funds Management LLC	4,018,101	$202,673,014
Mega JANUS HENDERSON GROUP PLC	1,656,164	$83,536,912
Large RA CAPITAL MANAGEMENT, L.P.	1,621,620	$81,794,512
Large BAKER BROS. ADVISORS LP	1,000,000	$50,440,000
Mid Caligan Partners LP	878,127	$44,292,725

Filter: New 90 Increased 106 Reduced 57 Sold out 22 Unchanged 15

Showing 100 of 276

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$1,156,464,880

13.50%

13,026,187

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	9,122,435	$809,889,779	70.0%	Defined
FIDELITY MANAGEMENT TRUST CO	3,792,622	$336,708,981	29.1%	Defined
Fidelity Institutional Asset Management Trust Co	76,237	$6,768,320	0.6%	Defined
FIAM LLC	34,893	$3,097,800	0.3%	Defined

BlackRock, Inc.

$577,656,386

6.74%

6,506,605

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	75,973	$6,744,882	1.2%	Sole
BlackRock Investment Management (Australia) Ltd	144	$12,784	0.0%	Sole
BlackRock Asset Management Canada Ltd	10,027	$890,197	0.2%	Sole
BlackRock Investment Management, LLC	206,300	$18,315,314	3.2%	Sole
BLACKROCK ADVISORS LLC	265,666	$23,585,827	4.1%	Sole
BlackRock Fund Advisors	3,416,000	$303,272,480	52.5%	Sole
BlackRock Institutional Trust Company, N.A.	2,307,242	$204,836,944	35.5%	Sole
BlackRock Japan Co. Ltd	1,753	$155,631	0.0%	Sole
BlackRock Fund Managers Ltd.	10,013	$888,954	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	12,658	$1,123,777	0.2%	Sole
BlackRock (Netherlands) B.V.	2,172	$192,830	0.0%	Sole
BlackRock Asset Management Ireland Ltd	136,152	$12,087,574	2.1%	Sole
BlackRock Asset Management Schweiz AG	9,056	$803,991	0.1%	Sole
Aperio Group, LLC	53,373	$4,738,454	0.8%	Sole
SpiderRock Advisors, LLC	76	$6,747	0.0%	Sole

PERCEPTIVE ADVISORS LLC

$383,484,854

4.48%

4,319,496

RTW INVESTMENTS, LP

$377,492,204

4.41%

4,251,996

Paradigm Biocapital Advisors LP

$340,984,270

3.98%

3,840,778

VANGUARD CAPITAL MANAGEMENT LLC

$306,173,899

3.57%

3,448,681

STATE STREET CORP

$271,437,392

3.17%

3,057,416

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	3,057,416	$271,437,392	100.0%	Defined

Venrock Adviser, LLC

$265,048,073

3.09%

2,985,448

PRICE T ROWE ASSOCIATES INC /MD/

$262,864,706

3.07%

2,960,855

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	106,706	$9,473,358	3.6%	Defined
Held directly	2,854,149	$253,391,348	96.4%	Sole

Driehaus Capital Management LLC

$248,509,957

2.90%

2,799,166

GEODE CAPITAL MANAGEMENT, LLC

$227,477,886

2.66%

2,562,265

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	281,499	$24,991,481	11.0%	Defined
Held directly	2,280,766	$202,486,405	89.0%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$206,866,100

2.41%

2,330,098

Capital World Investors

$205,574,795

2.40%

2,315,553

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	2,315,553	$205,574,795	100.0%	Defined

Jupiter Topco LLC

$195,931,777

2.29%

2,206,936

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	31,454	$2,792,486	1.4%	Defined
JANUS HENDERSON INVESTORS US LLC	2,175,482	$193,139,291	98.6%	Defined

TCG Crossover Management, LLC

$168,733,669

1.97%

1,900,582

TANG CAPITAL MANAGEMENT LLC

$167,989,516

1.96%

1,892,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TANG KEVIN	1,892,200	$167,989,516	100.0%	Other

BANK OF AMERICA CORP /DE/

$157,837,877

1.84%

1,777,854

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	1,725,431	$153,183,764	97.1%	Defined
BOFA SECURITIES, INC.	40,309	$3,578,633	2.3%	Defined
MANAGED ACCOUNT ADVISORS LLC	12,114	$1,075,480	0.7%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$152,905,794

1.78%

1,722,300

WELLINGTON MANAGEMENT GROUP LLP

$140,406,009

1.64%

1,581,505

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	1,049,103	$93,139,364	66.3%	Defined
Wellington Managment Canada LLC	20,928	$1,857,987	1.3%	Defined
Wellington Management Hong Kong Ltd	359	$31,872	0.0%	Defined
Wellington Management Japan Pte Ltd	2,924	$259,592	0.2%	Defined
Wellington Management Singapore Pte. Ltd.	46,541	$4,131,909	2.9%	Defined
Wellington Management International Ltd	113,050	$10,036,579	7.1%	Defined
Wellington Trust Company, NA joint	342,662	$30,421,532	21.7%	Defined
Wellington Management Australia Pty Ltd	4,241	$376,515	0.3%	Defined
Wellington Management Europe GmbH	1,697	$150,659	0.1%	Defined

GOLDMAN SACHS GROUP INC

$131,222,076

1.53%

1,478,059

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	819,038	$72,714,193	55.4%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	634,868	$56,363,581	43.0%	Defined
GOLDMAN SACHS INTERNATIONAL	8,450	$750,191	0.6%	Defined
GOLDMAN SACHS BANK AG	2,392	$212,361	0.2%	Defined
GOLDMAN SACHS WEALTH SERVICES, L.P.	5,343	$474,351	0.4%	Defined
Goldman Sachs Trust Company, N.A. joint	7,968	$707,399	0.5%	Defined

FRANKLIN RESOURCES INC

$130,767,877

1.53%

1,472,943

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	55	$4,882	0.0%	Defined
FRANKLIN ADVISERS INC	1,021,015	$90,645,711	69.3%	Defined
PUTNAM INVESTMENT MANAGEMENT LLC	281,280	$24,972,038	19.1%	Defined
PUTNAM ADVISORY CO LLC	170,593	$15,145,246	11.6%	Defined

Remedium Capital Partners, LLC

$129,988,923

1.52%

1,464,169

Affinity Asset Advisors, LLC

$113,561,516

1.33%

1,279,134

JPMORGAN CHASE & CO

$97,038,845

1.13%

1,093,026

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	346	$30,717	0.0%	Other
JPMorgan Chase Bank, N.A.	48,947	$4,345,514	4.5%	Defined
J.P. Morgan Investment Management Inc.	561,711	$49,868,702	51.4%	Defined
J.P. Morgan Securities LLC	7	$621	0.0%	Defined
JPMorgan Asset Management (UK) Ltd	482,013	$42,793,114	44.1%	Defined
55I, LLC	2	$177	0.0%	Defined

Holocene Advisors, LP

$90,126,792

1.05%

1,015,170

MARSHALL WACE, LLP

$88,042,503

1.03%

991,693

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	991,693	$88,042,503	100.0%	Other

Polar Capital Holdings Plc

$87,715,439

1.02%

988,009

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	988,009	$87,715,439	100.0%	Defined

Siren, L.L.C.

$85,992,130

1.00%

968,598

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	968,598	$85,992,130	100.0%	Defined

Capital International Investors

$84,802,300

0.99%

955,196

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	955,196	$84,802,300	100.0%	Defined

BRAIDWELL LP

$78,079,080

0.91%

879,467

Commodore Capital LP

$75,177,661

0.88%

846,786

UBS Group AG

$74,847,841

0.87%

843,071

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	3,482	$309,131	0.4%	Defined
UBS AG	783,878	$69,592,688	93.0%	Defined
UBS Switzerland AG	55,680	$4,943,270	6.6%	Defined
UBS Securities LLC	31	$2,752	0.0%	Defined

NORTHERN TRUST CORP

$59,884,683

0.70%

674,529

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	631,498	$56,064,392	93.6%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	31,472	$2,794,083	4.7%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	11,559	$1,026,208	1.7%	Other

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$57,969,611

0.68%

652,958

Pictet Asset Management Holding SA

$55,766,091

0.65%

628,138

EMERALD ADVISERS, LLC

$50,376,435

0.59%

567,430

VICTORY CAPITAL MANAGEMENT INC

$49,182,344

0.57%

553,980

VANGUARD FIDUCIARY TRUST CO

$48,952,315

0.57%

551,389

Candriam S.C.A.

$48,501,579

0.57%

546,312

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$46,349,460

0.54%

522,071

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	1,570	$139,384	0.3%	Defined
UBS Asset Management Switzerland AG	350,260	$31,096,082	67.1%	Defined
UBS Asset Management (UK) Ltd.	7,359	$653,331	1.4%	Defined
Held directly	162,882	$14,460,663	31.2%	Defined

MORGAN STANLEY

$44,386,711

0.52%

499,963

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	128	$11,363	0.0%	Defined
MORGAN STANLEY & CO. LLC	26,928	$2,390,667	5.4%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	431,366	$38,296,673	86.3%	Defined
MORGAN STANLEY SMITH BARNEY LLC	13,073	$1,160,620	2.6%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	28,468	$2,527,388	5.7%	Defined

VOYA INVESTMENT MANAGEMENT LLC

$38,325,792

0.45%

431,694

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	431,694	$38,325,792	100.0%	Defined

EMERALD MUTUAL FUND ADVISERS TRUST

$35,624,839

0.42%

401,271

SAMLYN CAPITAL, LLC

$35,518,657

0.41%

400,075

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SAMLYN ONSHORE FUND, LP joint	64,518	$5,727,908	16.1%	Defined
Samlyn Offshore Master Fund, Ltd.	152,706	$13,557,238	38.2%	Defined
Samlyn Net Neutral Master Fund, Ltd.	142,140	$12,619,189	35.5%	Defined
Samlyn Long Alpha Master Fund, Ltd.	40,711	$3,614,322	10.2%	Defined

AMERIPRISE FINANCIAL INC

$31,612,958

0.37%

356,082

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	346,224	$30,737,766	97.2%	Defined
Ameriprise Trust Co	9,502	$843,587	2.7%	Defined
Ameriprise Financial Services, LLC	356	$31,605	0.1%	Defined

Integral Health Asset Management, LLC

$28,853,500

0.34%

325,000

Woodline Partners LP

$27,171,030

0.32%

306,049

JENNISON ASSOCIATES LLC

$26,916,320

0.31%

303,180

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prudential Financial Inc	303,180	$26,916,320	100.0%	Defined

ADAR1 Capital Management, LLC

$25,211,921

0.29%

283,982

BNP PARIBAS ARBITRAGE, SA

$23,075,963

0.27%

259,923

Bank of New York Mellon Corp

$21,768,231

0.25%

245,193

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation joint	107,702	$9,561,782	43.9%	Defined
The Bank of New York Mellon	134,494	$11,940,377	54.9%	Defined
BNY Mellon, NA joint	906	$80,434	0.4%	Defined
BNY Mellon Advisors, Inc. joint	2,090	$185,550	0.9%	Other
Held directly	1	$88	0.0%	Defined

Bellevue Group AG

$20,413,274

0.24%

229,931

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	227,000	$20,153,060	98.7%	Defined
Bellevue Asset Management AG	2,931	$260,214	1.3%	Defined

Cormorant Asset Management, LP

$19,975,500

0.23%

225,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Chen Bihua	225,000	$19,975,500	100.0%	Defined

SEVEN GRAND MANAGERS, LLC

$19,975,500

0.23%

225,000

EVENTIDE ASSET MANAGEMENT, LLC

$17,899,468

0.21%

201,616

MILLENNIUM MANAGEMENT LLC

$17,464,091

0.20%

196,712

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$16,903,712

0.20%

190,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	190,400	$16,903,712	100.0%	Other

ORBIMED ADVISORS LLC

$16,525,953

0.19%

186,145

FRONTIER CAPITAL MANAGEMENT CO LLC

$16,240,614

0.19%

182,931

Nuveen, LLC

$16,078,500

0.19%

181,105

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	7,569	$671,975	4.2%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	13,160	$1,168,344	7.3%	Defined
TEACHERS ADVISORS, LLC joint	160,376	$14,238,181	88.6%	Defined

NEUBERGER BERMAN GROUP LLC

$16,058,881

0.19%

180,884

DEUTSCHE BANK AG\

$15,488,469

0.18%

174,459

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investment GmbH	90,927	$8,072,499	52.1%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	1,401	$124,380	0.8%	Defined
DWS Investments UK Ltd	82,131	$7,291,590	47.1%	Defined

Caption Management, LLC

$15,421,086

0.18%

173,700

Universal- Beteiligungs- und Servicegesellschaft mbH

$15,352,103

0.18%

172,923

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH joint	172,923	$15,352,103	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$13,778,656

0.16%

155,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	155,200	$13,778,656	100.0%	Other

Balyasny Asset Management L.P.

$13,054,388

0.15%

147,042

Soleus Capital Management, L.P.

$13,050,660

0.15%

147,000

Squarepoint Ops LLC

$12,394,131

0.14%

139,605

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	139,605	$12,394,131	100.0%	Defined

ARMISTICE CAPITAL, LLC

$12,215,062

0.14%

137,588

Russell Investments Group, Ltd.

$11,963,724

0.14%

134,757

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	79,855	$7,089,526	59.3%	Defined
Russell Investments Capital, LLC	25,475	$2,261,670	18.9%	Defined
Russell Investments France SAS	8,771	$778,689	6.5%	Defined
Russell Investments Trust Company	20,656	$1,833,839	15.3%	Defined

Ensign Peak Advisors, Inc

$11,241,323

0.13%

126,620

Invesco Ltd.

$10,701,628

0.12%

120,541

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	11,367	$1,009,161	9.4%	Defined
Invesco Trust Co joint	29,689	$2,635,789	24.6%	Defined
Invesco Capital Management LLC	79,485	$7,056,678	65.9%	Defined

Blackstone Inc.

$10,669,314

0.12%

120,177

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blackstone Alternative Asset Management L.P.	120,177	$10,669,314	100.0%	Other

Rhenman & Partners Asset Management AB

$10,591,454

0.12%

119,300

TD Asset Management Inc

$10,297,592

0.12%

115,990

Swiss National Bank

$9,987,750

0.12%

112,500

STEMPOINT CAPITAL LP

$9,492,890

0.11%

106,926

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$9,278,930

0.11%

104,516

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	104,516	$9,278,930	100.0%	Defined

CITADEL ADVISORS LLC

$9,153,217

0.11%

103,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	41,180	$3,655,960	39.9%	Defined
Held directly	61,920	$5,497,257	60.1%	Defined

Boxer Capital Management, LLC

$8,878,000

0.10%

100,000

RHUMBLINE ADVISERS

$8,413,059

0.10%

94,763

BARCLAYS PLC

$8,351,445

0.10%

94,069

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	92,220	$8,187,291	98.0%	Defined
BARCLAYS CAPITAL INC.	1,849	$164,154	2.0%	Defined

F/m Investments LLC

$8,222,626

0.10%

92,618

ALLIANCEBERNSTEIN L.P.

$8,215,701

0.10%

92,540

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	92,540	$8,215,701	100.0%	Defined

PRUDENTIAL FINANCIAL INC

$7,756,708

0.09%

87,370

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	70,370	$6,247,448	80.5%	Defined
Prudential Trust Co	17,000	$1,509,260	19.5%	Defined

FEDERATED HERMES, INC.

$7,630,641

0.09%

85,950

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED MDTA LLC	85,950	$7,630,641	100.0%	Defined

Granahan Investment Management, LLC

$7,367,940

0.09%

82,991

CITIGROUP INC

$7,332,606

0.09%

82,593

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	82,593	$7,332,606	100.0%	Defined

WELLS FARGO & COMPANY/MN

$7,324,880

0.09%

82,506

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	69,240	$6,147,127	83.9%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	1,814	$161,046	2.2%	Defined
WELLS FARGO CLEARING SERVICES, LLC	11,423	$1,014,133	13.8%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	29	$2,574	0.0%	Defined

HighVista Strategies LLC

$6,907,705

0.08%

77,807

MERCER GLOBAL ADVISORS INC /ADV

$6,316,253

0.07%

71,145

B Group, Inc.

$6,214,600

0.07%

70,000

Trexquant Investment LP

$5,948,881

0.07%

67,007

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$5,742,911

0.07%

64,687

Informed Momentum Co LLC

$5,361,690

0.06%

60,393

SILVERARC CAPITAL MANAGEMENT, LLC

$5,323,160

0.06%

59,959

PRINCIPAL FINANCIAL GROUP INC

$5,304,338

0.06%

59,747

Hudson Bay Capital Management LP

$5,183,597

0.06%

58,387

Atle Fund Management AB

$5,063,123

0.06%

57,030

RAYMOND JAMES FINANCIAL INC

$4,761,004

0.06%

53,627

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	148	$13,139	0.3%	Defined
Raymond James Financial Services Advisors, Inc.	600	$53,268	1.1%	Defined
CHARTWELL INVESTMENT PARTNERS, LLC	52,879	$4,694,597	98.6%	Defined

Key facts CIK 1636282 CUSIP 00773J202 13F (30d) 118 filings 117 filers Visit website Investor relations