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Equibles

SYRE

Spyre Therapeutics, Inc.

Company with tickers: SYRE

CIK
1636282
CUSIP
00773J202
Shares Outstanding
86,841,253
13F Activity (30d)
159 filings 157 filers

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Holders: 199
Total Value: $4,186,632,309
Total Shares: 83,002,229
Showing 1–100 of 202 holdings by value · page 1 of 3

Institutional Ownership Trend

11 quarters

Holder Concentration

Across 199 13F filers · Δ vs Dec 31, 2025
Top Holder
14.2%
Sep 2023 → Mar 2026 · range 13.5% – 27.1%
−0.1 pts
Top 5
35.3%
Sep 2023 → Mar 2026 · range 35.3% – 65.3%
−0.8 pts
Top 10
52.3%
Sep 2023 → Mar 2026 · range 52.3% – 89.4%
−2.9 pts
HHI
439
Sep 2023 → Mar 2026 · range 439 – 1,258
Broadly held −27

Quarterly Activity

vs Dec 31, 2025
New
58
Increased
66
Decreased
50
Sold Out
14
Unchanged
25
Holder count: +44
Institutional value: +57.0%
Shares held: +1.9%

Top Buyers

vs Dec 31, 2025
Institution Added Now Holds Open
Mega JPMORGAN CHASE & CO +916,348 979,299
Mega BANK OF AMERICA CORP /DE/ +808,366 1,228,093
Mid PERCEPTIVE ADVISORS LLC +714,000 3,783,225
Mid Paradigm Biocapital Advisors LP +490,000 1,957,266
Mega Capital World Investors +466,392 666,564

Top Sellers

vs Dec 31, 2025
Institution Sold Now Holds Open
Mega Capital International Investors −1,746,412 1,746,129
Mid BRAIDWELL LP −701,792 932,823
Mid Commodore Capital LP −475,865 1,912,380
Large Pictet Asset Management Holding SA −422,311 491,649
Mega FRANKLIN RESOURCES INC −226,441 882,833

Top New Positions

vs Dec 31, 2025
Institution Acquired Value (USD) Open
Mega VANGUARD CAPITAL MANAGEMENT LLC 3,057,401 $154,215,306
Mid Caligan Partners LP 878,127 $44,292,725
Mega VANGUARD PORTFOLIO MANAGEMENT LLC 585,130 $29,513,957
Mega VANGUARD FIDUCIARY TRUST CO 464,651 $23,436,996
Mid SAMLYN CAPITAL, LLC 396,661 $20,007,580

Top Sold-Out Positions

vs Dec 31, 2025
Institution Previously Held Last Value (USD) Open
Mega VANGUARD GROUP INC 4,035,074 $132,189,022
Mid DEERFIELD MANAGEMENT COMPANY, L.P. 710,626 $23,280,107
Large Point72 Asset Management, L.P. 662,351 $21,698,618
Small Parkman Healthcare Partners LLC 124,485 $4,078,128
Small Optimize Financial Inc 25,331 $829,843
Filter: New 58 Increased 66 Reduced 50 Sold out 14 Unchanged 25
Showing 100 of 202
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Mega FMR LLC $594,234,849 14.19% 11,781,024
Mega BlackRock, Inc. $278,490,382 6.65% 5,521,221
Large RTW INVESTMENTS, LP $210,435,478 5.03% 4,171,996
Mid Fairmount Funds Management LLC $202,673,014 4.84% 4,018,101
Mid PERCEPTIVE ADVISORS LLC $190,825,869 4.56% 3,783,225
Mid Venrock Adviser, LLC $185,893,997 4.44% 3,685,448
Mega VANGUARD CAPITAL MANAGEMENT LLC $154,215,306 3.68% 3,057,401
Large Driehaus Capital Management LLC $140,767,195 3.36% 2,790,785
Mega STATE STREET CORP $131,498,643 3.14% 2,607,031
Mid Paradigm Biocapital Advisors LP $98,724,497 2.36% 1,957,266
Mid Commodore Capital LP $96,460,447 2.30% 1,912,380
Mid TCG Crossover Management, LLC $95,865,356 2.29% 1,900,582
Mid TANG CAPITAL MANAGEMENT LLC $95,442,568 2.28% 1,892,200
Mega WELLINGTON MANAGEMENT GROUP LLP $92,043,462 2.20% 1,824,811
Mega Capital International Investors $88,074,746 2.10% 1,746,129
Mega GEODE CAPITAL MANAGEMENT, LLC $86,802,800 2.07% 1,720,912
Mega JANUS HENDERSON GROUP PLC $83,536,912 2.00% 1,656,164
Mid RA CAPITAL MANAGEMENT, L.P. $81,794,512 1.95% 1,621,620
Mega PRICE T ROWE ASSOCIATES INC /MD/ $80,639,940 1.93% 1,598,730
Small Remedium Capital Partners, LLC $73,452,291 1.75% 1,456,231
Mid Affinity Asset Advisors, LLC $64,519,518 1.54% 1,279,134
Mega BANK OF AMERICA CORP /DE/ Bank $61,945,010 1.48% 1,228,093
Large BAKER BROS. ADVISORS LP $50,440,000 1.20% 1,000,000
Mega JPMORGAN CHASE & CO $49,395,838 1.18% 979,299
Mid BRAIDWELL LP $47,051,592 1.12% 932,823
Mega FRANKLIN RESOURCES INC $44,530,096 1.06% 882,833
Mid Caligan Partners LP $44,292,725 1.06% 878,127
Mid Siren, L.L.C. $41,290,083 0.99% 818,598
Large Polar Capital Holdings Plc $39,991,202 0.96% 792,847
Mega UBS Group AG $33,857,092 0.81% 671,235
Mega Capital World Investors $33,621,488 0.80% 666,564
Mid EMERALD ADVISERS, LLC $30,938,130 0.74% 613,365
Large Candriam S.C.A. $30,782,624 0.74% 610,282
Mega VANGUARD PORTFOLIO MANAGEMENT LLC $29,513,957 0.70% 585,130
Mega NORTHERN TRUST CORP Bank $29,200,068 0.70% 578,907
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $28,380,217 0.68% 562,653
Large Pictet Asset Management Holding SA $24,798,775 0.59% 491,649
Mega VANGUARD FIDUCIARY TRUST CO Bank $23,436,996 0.56% 464,651
Mid EMERALD MUTUAL FUND ADVISERS TRUST Mutual Fund $20,585,219 0.49% 408,113
Mid SAMLYN CAPITAL, LLC $20,007,580 0.48% 396,661
Mid ADAR1 Capital Management, LLC $17,065,012 0.41% 338,323
Large Blackstone Inc. $14,771,202 0.35% 292,847
Mega VICTORY CAPITAL MANAGEMENT INC $14,734,835 0.35% 292,126
Mega GOLDMAN SACHS GROUP INC $13,615,671 0.33% 269,938
Large Woodline Partners LP $13,411,592 0.32% 265,892
Mega MORGAN STANLEY $12,444,504 0.30% 246,719
Large Caption Management, LLC $11,994,632 0.29% 237,800
Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $10,456,916 0.25% 207,314
Mid BOOTHBAY FUND MANAGEMENT, LLC $9,736,483 0.23% 193,031
Mega Bank of New York Mellon Corp Bank $9,653,962 0.23% 191,395
Small SILVERARC CAPITAL MANAGEMENT, LLC $9,413,011 0.22% 186,618
Mega FIRST TRUST ADVISORS LP $8,997,941 0.21% 178,389
Large Universal- Beteiligungs- und Servicegesellschaft mbH $8,594,017 0.21% 170,381
Small STEMPOINT CAPITAL LP $8,454,046 0.20% 167,606
Mega AMERIPRISE FINANCIAL INC $8,030,904 0.19% 159,217
Mega Nuveen, LLC $7,762,665 0.19% 153,899
Large Ensign Peak Advisors, Inc $7,492,206 0.18% 148,537
Mega MILLENNIUM MANAGEMENT LLC $7,396,471 0.18% 146,639
Small HighVista Strategies LLC $7,377,556 0.18% 146,264
Large MARSHALL WACE, LLP $7,024,223 0.17% 139,259
Mega TD Asset Management Inc $6,929,951 0.17% 137,390
Mega Invesco Ltd. $6,677,750 0.16% 132,390
Mega DEUTSCHE BANK AG\ Bank $6,518,966 0.16% 129,242
Mid ARMISTICE CAPITAL, LLC $6,099,759 0.15% 120,931
Mega MANUFACTURERS LIFE INSURANCE COMPANY, THE Insurance $5,691,700 0.14% 112,841
Mega CITADEL ADVISORS LLC $5,454,329 0.13% 108,135
Mid SEVEN GRAND MANAGERS, LLC $5,044,000 0.12% 100,000
Small B Group, Inc. $5,044,000 0.12% 100,000
Mid F/m Investments LLC $5,016,762 0.12% 99,460
Mega Swiss National Bank Bank $4,867,460 0.12% 96,500
Large ExodusPoint Capital Management, LP $4,391,558 0.10% 87,065
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $4,358,016 0.10% 86,400
Mega RHUMBLINE ADVISERS $4,293,503 0.10% 85,121
Large MERCER GLOBAL ADVISORS INC /ADV $3,585,830 0.09% 71,091
Mega ALLIANCEBERNSTEIN L.P. $3,576,196 0.09% 70,900
Large Rockefeller Capital Management L.P. $3,228,260 0.08% 64,002
Large ALPS ADVISORS INC $3,225,083 0.08% 63,939
Mega SCHRODER INVESTMENT MANAGEMENT GROUP $3,212,220 0.08% 63,684
Small Atle Fund Management AB $3,164,353 0.08% 62,735
Large PRUDENTIAL FINANCIAL INC $3,003,954 0.07% 59,555
Large FRED ALGER MANAGEMENT, LLC $2,998,809 0.07% 59,453
Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Pension $2,988,166 0.07% 59,242
Large Rafferty Asset Management, LLC $2,871,044 0.07% 56,920
Large Balyasny Asset Management L.P. $2,798,259 0.07% 55,477
Large VOYA INVESTMENT MANAGEMENT LLC $2,722,246 0.07% 53,970
Mid Susquehanna Portfolio Strategies, LLC $2,678,414 0.06% 53,101
Mega DIMENSIONAL FUND ADVISORS LP $2,405,836 0.06% 47,697
Mega BARCLAYS PLC $2,309,445 0.06% 45,786
Mega Legal & General Group Plc $2,259,306 0.05% 44,792
Large MetLife Investment Management, LLC $1,937,249 0.05% 38,407
Large MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. Mutual Fund $1,832,131 0.04% 36,323
Mega VANGUARD ASSET MANAGEMENT, Ltd $1,676,222 0.04% 33,232
Mega WELLS FARGO & COMPANY/MN $1,675,011 0.04% 33,208
Mega Vanguard Global Advisers, LLC $1,570,752 0.04% 31,141
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,460,843 0.03% 28,962
Mid Cinctive Capital Management LP $1,383,569 0.03% 27,430
Large STATE OF WISCONSIN INVESTMENT BOARD $1,337,820 0.03% 26,523
Mid PROFUND ADVISORS LLC $1,313,608 0.03% 26,043
Mid Waverly Advisors, LLC $1,309,725 0.03% 25,966
Large TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY Pension $1,301,301 0.03% 25,799

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