SYRE · Spyre Therapeutics, Inc. · Holdings

$99.75 +0.71 (+0.71%)

Russell 2000 member Rebalance outlook locked

Market Cap

$8.72B

88.17M

Volume · Oct 28 722.56K Avg daily vol (3M) 1.22M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of SYRE: 13F, 13D and 13G, insiders and funds →

The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.

Quarter:

Holders: 274

Total Value: $8,620,669,316

Total Shares: 97,099,560

Showing 1–100 of 282 holdings by value · page 1 of 3

Institutional Ownership Trend

13 quarters

Holder Concentration

Across 267 13F filers

Top Holder

13.5%

of institutional value

Top 5

33.1%

of institutional value

Top 10

48.9%

of institutional value

HHI

397

Broadly held

Who Holds SYRE

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 265 filers, like-for-like change +15.9%; actively managed books +12.6%; index-like books +30.2%.

Holder type	Share	Filers	Change	New	Exited
Registered adviser	48.8%	133	+7.5%	50	13
Exempt adviser	1.1%	3	+571.6%	1	1
Adviser	5.7%	10	+41.0%	3	0
Bank	8.3%	16	+25.5%	3	0
Insurer	0.2%	2	+130.4%	0	0
Benefit plan	0.2%	6	+36.8%	1	0
Non-US	0.9%	9	+188.8%	2	0
Holding company	24.3%	10	+18.6%	3	0
Broker-dealer	0.0%	0	-100.0%	0	1
Unknown	10.6%	76	+17.2%	25	7

Style	Share	Filers	Change	New	Exited
Index-like	21.4%	31	+30.2%	2	0
Systematic-like	1.1%	21	+28.9%	11	1
Concentrated	12.0%	34	-39.2%	12	11
Diversified active	65.5%	179	+33.1%	63	9
Unknown	0.0%	0	-100.0%	0	1
Not measured	0.0%	0	—	0	0

Turnover	Share	Filers	Change	New	Exited
Low turnover	45.9%	104	+0.5%	19	11
Medium turnover	38.7%	87	+24.7%	32	3
High turnover	4.7%	52	+151.1%	30	8
Unknown	10.6%	22	+38.8%	7	0
Not measured	0.0%	0	—	0	0

Holding horizon	Share	Filers	Change	New	Exited
Short horizon	11.4%	44	+39.7%	19	4
Medium horizon	22.2%	46	-13.9%	12	5
Long horizon	51.6%	141	+25.7%	39	9
Unknown	14.8%	34	+31.1%	18	4
Not measured	0.0%	0	—	0	0

13F book size	Share	Filers	Change	New	Exited
Under $1B	2.2%	44	-5.4%	21	8
$1B to $10B	24.3%	72	-9.1%	27	6
$10B to $100B	14.3%	80	+7.0%	29	8
$100B or more	59.2%	69	+35.0%	11	0
Not measured	0.0%	0	—	0	0

Client base	Share	Filers	Change	New	Exited
Individuals and high net worth	0.3%	28	-4.9%	9	3
Pooled investment vehicles	27.3%	50	-10.0%	23	9
Registered funds and BDCs	14.2%	22	+57.1%	7	1
Pension and profit sharing plans	0.0%	2	+284.7%	1	0
Insurance companies	0.5%	3	+391.8%	0	0
Governments and sovereign funds	0.9%	7	+19.4%	5	0
Corporations	1.5%	1	+0.5%	0	0
Other investment advisers	0.0%	3	+17.0%	0	0
Other	0.0%	1	+2333.3%	0	0
Diversified	4.1%	15	+21.5%	5	0
Unknown	51.2%	133	+25.2%	38	9

Private funds	Share	Filers	Change	New	Exited
Hedge funds	27.0%	55	-1.2%	23	8
Private equity funds	4.0%	7	-5.2%	1	1
Venture capital funds	0.2%	2	-87.6%	1	1
Real estate funds	0.0%	2	+367.3%	0	1
Liquidity funds	0.0%	1	new	1	0
Securitized asset funds	0.5%	1	+151.8%	0	0
Other private funds	4.7%	15	+85.4%	8	0
Mixed private funds	0.4%	4	+104.6%	1	0
Private funds, type not stated	0.0%	3	+6.9%	1	0
No private funds	12.9%	45	+39.0%	15	3
Unknown	50.1%	130	+23.1%	37	8

Location	Share	Filers	Change	New	Exited
United States	94.1%	212	+14.3%	70	19
Outside the US	5.9%	53	+48.5%	18	3

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 2 holders with no observed 2026-03-31 13F and 1 holder with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Conviction and Crowding

265 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders

4.53% of filers hold it in their top 10

Mar 31, 2026: 10

Holders above 5%

median weight 0.008%

Mar 31, 2026: 5

Crowding

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Private-fund advisers

—

of shares outstanding

Institutional ownership

—

holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice

Top 10 holders

49.2%

of 13F shares, Herfindahl 0.040

Active holders

+12.6%

like-for-like share change of active filers

5% stakes on record

1 13D, 2 13G (2 institutional, 0 passive, 0 exempt)

How long holders have held it value-weighted 8.2 quarters

Under 1 year 20.9% 1 to 3 years 62.4% 3 years or more 16.8% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net sellers of $275,275,767 (4 buying, 3 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost

$39.69

estimated per share

Mar 31, 2026: $25.30

Quarter-end price

$88.78

implied by 13F values

Estimated gain or loss

+123.7%

price against the estimated cost

Estimated at a loss

0.000%

of costed 13F value

Estimated cost covers 67.9% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies SYRE's active holders also own, quarter ended Jun 30, 2026

#	Company	Shared holders	Similarity
1	ORKA Oruka Therapeutics, Inc.	28	0.514
2	DNTH Dianthus Therapeutics, Inc.	26	0.486
3	TNGX Tango Therapeutics, Inc.	23	0.466
4	ELVN Enliven Therapeutics, Inc.	21	0.408
5	EWTX Edgewise Therapeutics, Inc.	18	0.406
6	COGT Cogent Biosciences, Inc.	23	0.398
7	ERAS Erasca, Inc.	18	0.382
8	CYTK Cytokinetics Inc	25	0.368
9	DMRA Damora Therapeutics, Inc.	13	0.365
10	PRAX Praxis Precision Medicines, Inc.	19	0.358

Shareholder Targets

13F filers that own its peers but not SYRE, quarter ended Jun 30, 2026

Found through its holder-overlap peers: ORKA, DNTH, TNGX, ELVN, EWTX, COGT, ERAS, CYTK, DMRA, PRAX, XENE, AMLX, DFTX, PTGX, RACC, SVRA, IMVT, RVMD, KOD, MBX. 898 filers in all.

#	Filer	In peers	Of book	Largest peers
1	BAKER BROS. ADVISORS LP Registered adviser, Concentrated	$4,045,707,377 10 held	20.4%	RVMD, KOD, PRAX
2	FARALLON CAPITAL MANAGEMENT LLC Registered adviser, Diversified active	$3,925,274,340 5 held	23.2%	RVMD, PTGX, TNGX
3	T. Rowe Price Investment Management, Inc. Adviser, Diversified active	$2,926,285,529 11 held	1.92%	CYTK, ERAS, DNTH
4	Darwin Global Management, Ltd. Exempt adviser, Concentrated	$1,990,753,064 1 held	51.4%	RVMD
5	Avoro Capital Advisors LLC Registered adviser, Concentrated	$1,641,439,814 5 held	14.7%	RVMD, CYTK, XENE
6	Nextech Invest, Ltd. Exempt adviser, Concentrated	$1,423,531,573 1 held	67.8%	RVMD
7	DEERFIELD MANAGEMENT COMPANY, L.P. Registered adviser, Concentrated	$1,386,032,725 7 held	17.3%	RVMD, PRAX, COGT
8	Fairmount Funds Management LLC Registered adviser, Concentrated	$1,133,736,501 5 held	74.9%	ORKA, DNTH, DMRA
9	Deep Track Capital, LP Adviser, Diversified active	$1,047,953,526 8 held	15.4%	IMVT, ORKA, TNGX
10	Frazier Life Sciences Management, L.P. Registered adviser, Concentrated	$983,427,101 4 held	21.4%	ERAS, MBX, CYTK

Fund Ownership of SYRE by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 15.38% of shares outstanding.

Fund type	Of shares outstanding	Change	Shares	Funds
Index funds	2.97%	+0.59 pp	2,621,253	64
Index ETFs	12.41%	+2.92 pp	10,942,997	46
Active ETFs	0.11%	+0.08 pp	95,963	14
Active funds	21.09%	+6.67 pp	18,597,503	150
Unclassified	0.35%	+0.24 pp	307,635	11
All registered funds	36.93%	+10.50 pp	32,565,351	285

How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 138 Exempt adviser 3 Adviser 10 Bank 16 Insurer 2 Benefit plan 6 Non-US 9 Holding company 10 Unknown 80

Showing 100 of 282

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

FMR LLC

$1,156,464,880

13.42%

13,026,187

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	9,122,435	$809,889,779	70.0%	Defined
FIDELITY MANAGEMENT TRUST CO	3,792,622	$336,708,981	29.1%	Defined
Fidelity Institutional Asset Management Trust Co	76,237	$6,768,320	0.6%	Defined
FIAM LLC	34,893	$3,097,800	0.3%	Defined

BlackRock, Inc.

$577,656,386

6.70%

6,506,605

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	75,973	$6,744,882	1.2%	Sole
BlackRock Investment Management (Australia) Ltd	144	$12,784	0.0%	Sole
BlackRock Asset Management Canada Ltd	10,027	$890,197	0.2%	Sole
BlackRock Investment Management, LLC	206,300	$18,315,314	3.2%	Sole
BLACKROCK ADVISORS LLC	265,666	$23,585,827	4.1%	Sole
BlackRock Fund Advisors	3,416,000	$303,272,480	52.5%	Sole
BlackRock Institutional Trust Company, N.A.	2,307,242	$204,836,944	35.5%	Sole
BlackRock Japan Co. Ltd	1,753	$155,631	0.0%	Sole
BlackRock Fund Managers Ltd.	10,013	$888,954	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	12,658	$1,123,777	0.2%	Sole
BlackRock (Netherlands) B.V.	2,172	$192,830	0.0%	Sole
BlackRock Asset Management Ireland Ltd	136,152	$12,087,574	2.1%	Sole
BlackRock Asset Management Schweiz AG	9,056	$803,991	0.1%	Sole
Aperio Group, LLC	53,373	$4,738,454	0.8%	Sole
SpiderRock Advisors, LLC	76	$6,747	0.0%	Sole

PERCEPTIVE ADVISORS LLC

$383,484,854

4.45%

4,319,496

RTW INVESTMENTS, LP

$377,492,204

4.38%

4,251,996

Paradigm Biocapital Advisors LP

$340,984,270

3.96%

3,840,778

VANGUARD CAPITAL MANAGEMENT LLC

$306,173,899

3.55%

3,448,681

STATE STREET CORP

$271,437,392

3.15%

3,057,416

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	3,057,416	$271,437,392	100.0%	Defined

Venrock Adviser, LLC

$265,048,073

3.07%

2,985,448

PRICE T ROWE ASSOCIATES INC /MD/

$262,864,706

3.05%

2,960,855

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	106,706	$9,473,358	3.6%	Defined
Held directly	2,854,149	$253,391,348	96.4%	Sole

Driehaus Capital Management LLC

$248,509,957

2.88%

2,799,166

GEODE CAPITAL MANAGEMENT, LLC

$227,477,886

2.64%

2,562,265

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	281,499	$24,991,481	11.0%	Defined
Held directly	2,280,766	$202,486,405	89.0%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$206,866,100

2.40%

2,330,098

Capital World Investors

$205,574,795

2.38%

2,315,553

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	2,315,553	$205,574,795	100.0%	Defined

Jupiter Topco LLC

$195,931,777

2.27%

2,206,936

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	31,454	$2,792,486	1.4%	Defined
JANUS HENDERSON INVESTORS US LLC	2,175,482	$193,139,291	98.6%	Defined

TCG Crossover Management, LLC

$168,733,669

1.96%

1,900,582

TANG CAPITAL MANAGEMENT LLC

$167,989,516

1.95%

1,892,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TANG KEVIN	1,892,200	$167,989,516	100.0%	Other

BANK OF AMERICA CORP /DE/

$157,837,877

1.83%

1,777,854

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	1,725,431	$153,183,764	97.1%	Defined
BOFA SECURITIES, INC.	40,309	$3,578,633	2.3%	Defined
MANAGED ACCOUNT ADVISORS LLC	12,114	$1,075,480	0.7%	Defined

ADAGE CAPITAL PARTNERS GP, L.L.C.

$152,905,794

1.77%

1,722,300

WELLINGTON MANAGEMENT GROUP LLP

$140,406,009

1.63%

1,581,505

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	1,049,103	$93,139,364	66.3%	Defined
Wellington Managment Canada LLC	20,928	$1,857,987	1.3%	Defined
Wellington Management Hong Kong Ltd	359	$31,872	0.0%	Defined
Wellington Management Japan Pte Ltd	2,924	$259,592	0.2%	Defined
Wellington Management Singapore Pte. Ltd.	46,541	$4,131,909	2.9%	Defined
Wellington Management International Ltd	113,050	$10,036,579	7.1%	Defined
Wellington Trust Company, NA joint	342,662	$30,421,532	21.7%	Defined
Wellington Management Australia Pty Ltd	4,241	$376,515	0.3%	Defined
Wellington Management Europe GmbH	1,697	$150,659	0.1%	Defined

GOLDMAN SACHS GROUP INC

$131,222,076

1.52%

1,478,059

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	819,038	$72,714,193	55.4%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	634,868	$56,363,581	43.0%	Defined
GOLDMAN SACHS INTERNATIONAL	8,450	$750,191	0.6%	Defined
GOLDMAN SACHS BANK AG	2,392	$212,361	0.2%	Defined
GOLDMAN SACHS WEALTH SERVICES, L.P.	5,343	$474,351	0.4%	Defined
Goldman Sachs Trust Company, N.A. joint	7,968	$707,399	0.5%	Defined

FRANKLIN RESOURCES INC

$130,767,877

1.52%

1,472,943

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FIDUCIARY TRUST INTERNATIONAL LLC	55	$4,882	0.0%	Defined
FRANKLIN ADVISERS INC	1,021,015	$90,645,711	69.3%	Defined
PUTNAM INVESTMENT MANAGEMENT LLC	281,280	$24,972,038	19.1%	Defined
PUTNAM ADVISORY CO LLC	170,593	$15,145,246	11.6%	Defined

Remedium Capital Partners, LLC

$129,988,923

1.51%

1,464,169

Affinity Asset Advisors, LLC

$113,561,516

1.32%

1,279,134

JPMORGAN CHASE & CO

$97,038,845

1.13%

1,093,026

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	346	$30,717	0.0%	Other
JPMorgan Chase Bank, N.A.	48,947	$4,345,514	4.5%	Defined
J.P. Morgan Investment Management Inc.	561,711	$49,868,702	51.4%	Defined
J.P. Morgan Securities LLC	7	$621	0.0%	Defined
JPMorgan Asset Management (UK) Ltd	482,013	$42,793,114	44.1%	Defined
55I, LLC	2	$177	0.0%	Defined

Holocene Advisors, LP

$90,126,792

1.05%

1,015,170

MARSHALL WACE, LLP

$88,042,503

1.02%

991,693

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	991,693	$88,042,503	100.0%	Other

Polar Capital Holdings Plc

$87,715,439

1.02%

988,009

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	988,009	$87,715,439	100.0%	Defined

Siren, L.L.C.

$85,992,130

1.00%

968,598

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	968,598	$85,992,130	100.0%	Defined

Capital International Investors

$84,802,300

0.98%

955,196

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	955,196	$84,802,300	100.0%	Defined

BRAIDWELL LP

$78,079,080

0.91%

879,467

Commodore Capital LP

$75,177,661

0.87%

846,786

UBS Group AG

$74,847,841

0.87%

843,071

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	3,482	$309,131	0.4%	Defined
UBS AG	783,878	$69,592,688	93.0%	Defined
UBS Switzerland AG	55,680	$4,943,270	6.6%	Defined
UBS Securities LLC	31	$2,752	0.0%	Defined

NORTHERN TRUST CORP

$59,884,683

0.69%

674,529

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	631,498	$56,064,392	93.6%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	31,472	$2,794,083	4.7%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	11,559	$1,026,208	1.7%	Other

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$57,969,611

0.67%

652,958

Pictet Asset Management Holding SA

$55,766,091

0.65%

628,138

Assenagon Asset Management S.A.

$53,348,912

0.62%

599,224

EMERALD ADVISERS, LLC

$50,376,435

0.58%

567,430

VICTORY CAPITAL MANAGEMENT INC

$49,182,344

0.57%

553,980

VANGUARD FIDUCIARY TRUST CO

$48,952,315

0.57%

551,389

Candriam S.C.A.

$48,501,579

0.56%

546,312

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$46,349,460

0.54%

522,071

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	1,570	$139,384	0.3%	Defined
UBS Asset Management Switzerland AG	350,260	$31,096,082	67.1%	Defined
UBS Asset Management (UK) Ltd.	7,359	$653,331	1.4%	Defined
Held directly	162,882	$14,460,663	31.2%	Defined

MORGAN STANLEY

$44,386,711

0.51%

499,963

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	128	$11,363	0.0%	Defined
MORGAN STANLEY & CO. LLC	26,928	$2,390,667	5.4%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	431,366	$38,296,673	86.3%	Defined
MORGAN STANLEY SMITH BARNEY LLC	13,073	$1,160,620	2.6%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	28,468	$2,527,388	5.7%	Defined

VOYA INVESTMENT MANAGEMENT LLC

$38,325,792

0.44%

431,694

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	431,694	$38,325,792	100.0%	Defined

EMERALD MUTUAL FUND ADVISERS TRUST

$35,624,839

0.41%

401,271

SAMLYN CAPITAL, LLC

$35,518,657

0.41%

400,075

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SAMLYN ONSHORE FUND, LP joint	64,518	$5,727,908	16.1%	Defined
Samlyn Offshore Master Fund, Ltd.	152,706	$13,557,238	38.2%	Defined
Samlyn Net Neutral Master Fund, Ltd.	142,140	$12,619,189	35.5%	Defined
Samlyn Long Alpha Master Fund, Ltd.	40,711	$3,614,322	10.2%	Defined

AMERIPRISE FINANCIAL INC

$31,612,958

0.37%

356,082

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC	346,224	$30,737,766	97.2%	Defined
Ameriprise Trust Co	9,502	$843,587	2.7%	Defined
Ameriprise Financial Services, LLC	356	$31,605	0.1%	Defined

Integral Health Asset Management, LLC

$28,853,500

0.33%

325,000

Woodline Partners LP

$27,171,030

0.32%

306,049

JENNISON ASSOCIATES LLC

$26,916,320

0.31%

303,180

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prudential Financial Inc	303,180	$26,916,320	100.0%	Defined

ADAR1 Capital Management, LLC

$25,211,921

0.29%

283,982

BNP PARIBAS ARBITRAGE, SA

$23,075,963

0.27%

259,923

Bank of New York Mellon Corp

$21,768,231

0.25%

245,193

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation joint	107,702	$9,561,782	43.9%	Defined
The Bank of New York Mellon	134,494	$11,940,377	54.9%	Defined
BNY Mellon, NA joint	906	$80,434	0.4%	Defined
BNY Mellon Advisors, Inc. joint	2,090	$185,550	0.9%	Other
Held directly	1	$88	0.0%	Defined

Bellevue Group AG

$20,413,274

0.24%

229,931

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BB Biotech AG joint	227,000	$20,153,060	98.7%	Defined
Bellevue Asset Management AG	2,931	$260,214	1.3%	Defined

Cormorant Asset Management, LP

$19,975,500

0.23%

225,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Chen Bihua	225,000	$19,975,500	100.0%	Defined

SEVEN GRAND MANAGERS, LLC

$19,975,500

0.23%

225,000

EVENTIDE ASSET MANAGEMENT, LLC

$17,899,468

0.21%

201,616

MILLENNIUM MANAGEMENT LLC

$17,464,091

0.20%

196,712

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$16,903,712

0.20%

190,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	190,400	$16,903,712	100.0%	Other

ORBIMED ADVISORS LLC

$16,525,953

0.19%

186,145

FRONTIER CAPITAL MANAGEMENT CO LLC

$16,240,614

0.19%

182,931

Nuveen, LLC

$16,078,500

0.19%

181,105

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	7,569	$671,975	4.2%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	13,160	$1,168,344	7.3%	Defined
TEACHERS ADVISORS, LLC joint	160,376	$14,238,181	88.6%	Defined

NEUBERGER BERMAN GROUP LLC

$16,058,881

0.19%

180,884

DEUTSCHE BANK AG\

$15,488,469

0.18%

174,459

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investment GmbH	90,927	$8,072,499	52.1%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC	1,401	$124,380	0.8%	Defined
DWS Investments UK Ltd	82,131	$7,291,590	47.1%	Defined

Caption Management, LLC

$15,421,086

0.18%

173,700

Universal- Beteiligungs- und Servicegesellschaft mbH

$15,352,103

0.18%

172,923

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Universal-Investment-Gesellschaft mbH joint	172,923	$15,352,103	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$13,778,656

0.16%

155,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	155,200	$13,778,656	100.0%	Other

Balyasny Asset Management L.P.

$13,054,388

0.15%

147,042

Soleus Capital Management, L.P.

$13,050,660

0.15%

147,000

Squarepoint Ops LLC

$12,394,131

0.14%

139,605

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	139,605	$12,394,131	100.0%	Defined

ARMISTICE CAPITAL, LLC

$12,215,062

0.14%

137,588

Russell Investments Group, Ltd.

$11,963,724

0.14%

134,757

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	79,855	$7,089,526	59.3%	Defined
Russell Investments Capital, LLC	25,475	$2,261,670	18.9%	Defined
Russell Investments France SAS	8,771	$778,689	6.5%	Defined
Russell Investments Trust Company	20,656	$1,833,839	15.3%	Defined

Ensign Peak Advisors, Inc

$11,241,323

0.13%

126,620

Invesco Ltd.

$10,701,628

0.12%

120,541

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	11,367	$1,009,161	9.4%	Defined
Invesco Trust Co joint	29,689	$2,635,789	24.6%	Defined
Invesco Capital Management LLC	79,485	$7,056,678	65.9%	Defined

Blackstone Inc.

$10,669,314

0.12%

120,177

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blackstone Alternative Asset Management L.P.	120,177	$10,669,314	100.0%	Other

Rhenman & Partners Asset Management AB

$10,591,454

0.12%

119,300

TD Asset Management Inc

$10,297,592

0.12%

115,990

Swiss National Bank

$9,987,750

0.12%

112,500

STEMPOINT CAPITAL LP

$9,492,890

0.11%

106,926

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$9,278,930

0.11%

104,516

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	104,516	$9,278,930	100.0%	Defined

CITADEL ADVISORS LLC

$9,153,217

0.11%

103,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	41,180	$3,655,960	39.9%	Defined
Held directly	61,920	$5,497,257	60.1%	Defined

Boxer Capital Management, LLC

$8,878,000

0.10%

100,000

RHUMBLINE ADVISERS

$8,413,059

0.10%

94,763

BARCLAYS PLC

$8,351,445

0.10%

94,069

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	92,220	$8,187,291	98.0%	Defined
BARCLAYS CAPITAL INC.	1,849	$164,154	2.0%	Defined

F/m Investments LLC

$8,222,626

0.10%

92,618

ALLIANCEBERNSTEIN L.P.

$8,215,701

0.10%

92,540

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	92,540	$8,215,701	100.0%	Defined

PRUDENTIAL FINANCIAL INC

$7,756,708

0.09%

87,370

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	70,370	$6,247,448	80.5%	Defined
Prudential Trust Co	17,000	$1,509,260	19.5%	Defined

FEDERATED HERMES, INC.

$7,630,641

0.09%

85,950

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED MDTA LLC	85,950	$7,630,641	100.0%	Defined

Granahan Investment Management, LLC

$7,367,940

0.09%

82,991

CITIGROUP INC

$7,332,606

0.09%

82,593

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	82,593	$7,332,606	100.0%	Defined

WELLS FARGO & COMPANY/MN

$7,324,880

0.08%

82,506

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	69,240	$6,147,127	83.9%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	1,814	$161,046	2.2%	Defined
WELLS FARGO CLEARING SERVICES, LLC	11,423	$1,014,133	13.8%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	29	$2,574	0.0%	Defined

HighVista Strategies LLC

$6,907,705

0.08%

77,807

MERCER GLOBAL ADVISORS INC /ADV

$6,316,253

0.07%

71,145

B Group, Inc.

$6,214,600

0.07%

70,000

Trexquant Investment LP

$5,948,881

0.07%

67,007

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

$5,742,911

0.07%

64,687

Informed Momentum Co LLC

$5,361,690

0.06%

60,393

SILVERARC CAPITAL MANAGEMENT, LLC

$5,323,160

0.06%

59,959

PRINCIPAL FINANCIAL GROUP INC

$5,304,338

0.06%

59,747

Hudson Bay Capital Management LP

$5,183,597

0.06%

58,387

Atle Fund Management AB

$5,063,123

0.06%

57,030

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Key facts CIK 1636282 CUSIP 00773J202 13F (30d) 27 filings 27 filers Visit website Investor relations