Skip to main content
Equibles
SYRE logo

SYRE · Spyre Therapeutics, Inc.

Track SYRE — free Ask ALVIS about SYRE
$97.87 -2.09 (-2.09%) At close · Jul 29
Going-concern doubt — flagged May 5, 2026

Substantial doubt about the company's ability to continue as a going concern.

“We will need to raise additional capital to continue to fund our operations in the future. If we are unable to raise additional capital when needed, we will not be able to continue as a going concern.”
View the 10-Q filed May 5, 2026
Market Cap
$8.50B
Shares
86.84M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

The Jun 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out.
Holders: 201
Total Value: $4,164,680,870
Total Shares: 82,391,024
Showing 1–100 of 204 holdings by value · page 1 of 3

Institutional Ownership Trend

12 quarters

Holder Concentration

Across 198 13F filers
Top Holder
14.3%
Sep 2023 → Mar 2026 · range 13.5% – 24.6%
of institutional value
Top 5
35.5%
Sep 2023 → Mar 2026 · range 35.5% – 62.0%
of institutional value
Top 10
52.6%
Sep 2023 → Mar 2026 · range 52.6% – 87.4%
of institutional value
HHI
444
Sep 2023 → Mar 2026 · range 444 – 1,122
Broadly held
Showing 100 of 204
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Mega FMR LLC $594,234,849 14.27% 11,781,024
Mega BlackRock, Inc. $278,490,382 6.69% 5,521,221
Large RTW INVESTMENTS, LP $210,435,478 5.05% 4,171,996
Mid Fairmount Funds Management LLC $202,673,014 4.87% 4,018,101
Mid PERCEPTIVE ADVISORS LLC $190,825,869 4.58% 3,783,225
Mid Venrock Adviser, LLC $185,893,997 4.46% 3,685,448
Mega VANGUARD CAPITAL MANAGEMENT LLC $154,215,306 3.70% 3,057,401
Large Driehaus Capital Management LLC $140,767,195 3.38% 2,790,785
Mega STATE STREET CORP $131,498,643 3.16% 2,607,031
Mid Paradigm Biocapital Advisors LP $98,724,497 2.37% 1,957,266
Mid Commodore Capital LP $96,460,447 2.32% 1,912,380
Mid TCG Crossover Management, LLC $95,865,356 2.30% 1,900,582
Mid TANG CAPITAL MANAGEMENT LLC $95,442,568 2.29% 1,892,200
Mega WELLINGTON MANAGEMENT GROUP LLP $92,043,462 2.21% 1,824,811
Mega Capital International Investors $88,074,746 2.11% 1,746,129
Mega GEODE CAPITAL MANAGEMENT, LLC $86,802,800 2.08% 1,720,912
Mega JANUS HENDERSON GROUP PLC $83,536,912 2.01% 1,656,164
Mid RA CAPITAL MANAGEMENT, L.P. $81,794,512 1.96% 1,621,620
Mega PRICE T ROWE ASSOCIATES INC /MD/ $80,639,940 1.94% 1,598,730
Small Remedium Capital Partners, LLC $73,452,291 1.76% 1,456,231
Mid Affinity Asset Advisors, LLC $64,519,518 1.55% 1,279,134
Mega BANK OF AMERICA CORP /DE/ Bank $61,945,010 1.49% 1,228,093
Large BAKER BROS. ADVISORS LP $50,440,000 1.21% 1,000,000
Mega JPMORGAN CHASE & CO $49,395,838 1.19% 979,299
Mid BRAIDWELL LP $47,051,592 1.13% 932,823
Mega FRANKLIN RESOURCES INC $44,530,096 1.07% 882,833
Mid Caligan Partners LP $44,292,725 1.06% 878,127
Mid Siren, L.L.C. $41,290,083 0.99% 818,598
Large Polar Capital Holdings Plc $39,991,202 0.96% 792,847
Mega UBS Group AG $33,857,092 0.81% 671,235
Mega Capital World Investors $33,621,488 0.81% 666,564
Mid EMERALD ADVISERS, LLC $30,938,130 0.74% 613,365
Large Candriam S.C.A. $30,782,624 0.74% 610,282
Mega NORTHERN TRUST CORP Bank $29,200,068 0.70% 578,907
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $28,380,217 0.68% 562,653
Large Pictet Asset Management Holding SA $24,798,775 0.60% 491,649
Mega VANGUARD FIDUCIARY TRUST CO Bank $23,436,996 0.56% 464,651
Mid EMERALD MUTUAL FUND ADVISERS TRUST Mutual Fund $20,585,219 0.49% 408,113
Mid SAMLYN CAPITAL, LLC $20,007,580 0.48% 396,661
Mid ADAR1 Capital Management, LLC $17,065,012 0.41% 338,323
Large Blackstone Inc. $14,771,202 0.35% 292,847
Mega VICTORY CAPITAL MANAGEMENT INC $14,734,835 0.35% 292,126
Mega GOLDMAN SACHS GROUP INC $13,615,671 0.33% 269,938
Large Woodline Partners LP $13,411,592 0.32% 265,892
Mega MORGAN STANLEY $12,444,504 0.30% 246,719
Large Caption Management, LLC $11,994,632 0.29% 237,800
Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $10,456,916 0.25% 207,314
Mid BOOTHBAY FUND MANAGEMENT, LLC $9,736,483 0.23% 193,031
Mega Bank of New York Mellon Corp Bank $9,653,962 0.23% 191,395
Small SILVERARC CAPITAL MANAGEMENT, LLC $9,413,011 0.23% 186,618
Mega FIRST TRUST ADVISORS LP $8,997,941 0.22% 178,389
Large Universal- Beteiligungs- und Servicegesellschaft mbH $8,594,017 0.21% 170,381
Small STEMPOINT CAPITAL LP $8,454,046 0.20% 167,606
Mega AMERIPRISE FINANCIAL INC $8,030,904 0.19% 159,217
Mega Nuveen, LLC $7,762,665 0.19% 153,899
Large Ensign Peak Advisors, Inc $7,492,206 0.18% 148,537
Mega MILLENNIUM MANAGEMENT LLC $7,396,471 0.18% 146,639
Small HighVista Strategies LLC $7,377,556 0.18% 146,264
Large MARSHALL WACE, LLP $7,024,223 0.17% 139,259
Mega TD Asset Management Inc $6,929,951 0.17% 137,390
Mega Invesco Ltd. $6,677,750 0.16% 132,390
Mega DEUTSCHE BANK AG\ Bank $6,518,966 0.16% 129,242
Mid ARMISTICE CAPITAL, LLC $6,099,759 0.15% 120,931
Mega MANUFACTURERS LIFE INSURANCE COMPANY, THE Insurance $5,691,700 0.14% 112,841
Mega CITADEL ADVISORS LLC $5,454,329 0.13% 108,135
Small Atle Fund Management AB $5,063,123 0.12% 57,030
Mid SEVEN GRAND MANAGERS, LLC $5,044,000 0.12% 100,000
Small B Group, Inc. $5,044,000 0.12% 100,000
Mid F/m Investments LLC $5,016,762 0.12% 99,460
Mega Swiss National Bank Bank $4,867,460 0.12% 96,500
Large ExodusPoint Capital Management, LP $4,391,558 0.11% 87,065
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $4,358,016 0.10% 86,400
Mega RHUMBLINE ADVISERS $4,293,503 0.10% 85,121
Small Moody Aldrich Partners LLC $3,769,421 0.09% 42,458
Large MERCER GLOBAL ADVISORS INC /ADV $3,585,830 0.09% 71,091
Mega ALLIANCEBERNSTEIN L.P. $3,576,196 0.09% 70,900
Large Rockefeller Capital Management L.P. $3,228,260 0.08% 64,002
Mega SCHRODER INVESTMENT MANAGEMENT GROUP $3,212,220 0.08% 63,684
Large PRUDENTIAL FINANCIAL INC $3,003,954 0.07% 59,555
Large FRED ALGER MANAGEMENT, LLC $2,998,809 0.07% 59,453
Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Pension $2,988,166 0.07% 59,242
Large Rafferty Asset Management, LLC $2,871,044 0.07% 56,920
Large Balyasny Asset Management L.P. $2,798,259 0.07% 55,477
Large VOYA INVESTMENT MANAGEMENT LLC $2,722,246 0.07% 53,970
Mid Susquehanna Portfolio Strategies, LLC $2,678,414 0.06% 53,101
Mega DIMENSIONAL FUND ADVISORS LP $2,405,836 0.06% 47,697
Large NEW YORK STATE COMMON RETIREMENT FUND Pension $2,322,928 0.06% 26,165
Mega BARCLAYS PLC $2,309,445 0.06% 45,786
Large Handelsbanken Fonder AB $2,308,280 0.06% 26,000
Mega Legal & General Group Plc $2,259,306 0.05% 44,792
Large Police & Firemen's Retirement System of New Jersey Pension $1,950,319 0.05% 21,968
Large MetLife Investment Management, LLC $1,937,249 0.05% 38,407
Large MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. Mutual Fund $1,832,131 0.04% 36,323
Mega VANGUARD ASSET MANAGEMENT, Ltd $1,676,222 0.04% 33,232
Mega WELLS FARGO & COMPANY/MN $1,675,011 0.04% 33,208
Mega Vanguard Global Advisers, LLC $1,570,752 0.04% 31,141
Small Ellsworth Advisors, LLC $1,469,575 0.04% 16,553
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $1,460,843 0.04% 28,962
Mid Cinctive Capital Management LP $1,383,569 0.03% 27,430
Large STATE OF WISCONSIN INVESTMENT BOARD $1,337,820 0.03% 26,523
Key facts CIK 1636282 CUSIP 00773J202 13F (30d) 25 filings 25 filers Visit website Investor relations

Report a Problem

Category
Description
Email (optional, for follow-up)