PRICE T ROWE ASSOCIATES INC /MD/

Position in SYRE — Spyre Therapeutics, Inc.

CIK 80255 BALTIMORE, MD

Position in SYRE

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$80,639,940

+$28,162,286 QoQ

Shares Held

1,598,730

-0.2% QoQ

Ownership

1.84%

of shares outstanding

% of Portfolio

0.01%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2024

9 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Mar 31, 2026

PRICE T ROWE ASSOCIATES INC /MD/ holds $14,301,022,166 across 256 Biotechnology names. SYRE ranks #36 (0.6% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	ARGX	Argenx SE	3,374,955	$2,464,560,888
2	REGN	Regeneron Pharmaceuticals, Inc.	2,177,527	$1,682,444,460
3	VRTX	Vertex Pharmaceuticals Inc / Ma	1,760,122	$785,964,877
4	INSM	INSMED Inc	3,092,807	$505,735,799
5	KYMR	Kymera Therapeutics, Inc.	6,060,847	$504,807,946
6	ALNY	Alnylam Pharmaceuticals, Inc.	1,432,748	$474,053,330
7	ASND	Ascendis Pharma A/S	1,530,345	$350,035,811
8	RVMD	Revolution Medicines, Inc.	3,232,213	$314,332,713

9 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$80,639,940	1,598,730	-0.2%	Shares	Defined	2026-05-15
2025-12-31	$52,477,654	1,601,882	+158.1%	Shares	Sole	2026-02-17
2025-09-30	$10,401,590	620,620	-33.3%	Shares	Sole	2025-11-14
2025-06-30	$13,929,300	930,481	+274.4%	Shares	Sole	2025-08-14
2025-03-31	$4,010,224	248,542	-50.9%	Shares	Sole	2025-05-14
2024-12-31	$11,790,155	506,450	+18.0%	Shares	Sole	2025-02-14
2024-09-30	$12,620,624	429,127	+39.3%	Shares	Sole	2024-11-14
2024-06-30	$7,240,514	307,976	+292.2%	Shares	Defined	2024-08-14
2024-03-31	$2,978,604	78,529	—	Shares	Sole	2024-05-15
No filing history on record for this holder in this stock.