MANUFACTURERS LIFE INSURANCE COMPANY, THE

Insurance

Position in SYRE — Spyre Therapeutics, Inc.

CIK 928047 TORONTO, A6

Position in SYRE

as of Mar 31, 2026 · filed May 15, 2026 Compact

Position Value

$5,691,700

+$1,465,235 QoQ

Shares Held

112,841

-12.5% QoQ

Ownership

0.130%

of shares outstanding

% of Portfolio

0.01%

of 13F equity value

Holder Rank

—

not a current holder

Holding Since

Mar 2024

9 quarters on record

Voting authority Sole 100% Shared 0% None 0%

Healthcare · as of Mar 31, 2026

MANUFACTURERS LIFE INSURANCE COMPANY, THE holds $1,624,014,581 across 225 Biotechnology names. SYRE ranks #38 (0.4% of the industry book) .

#	Ticker	Company	Shares	Value (USD)
1	REGN	Regeneron Pharmaceuticals, Inc.	408,931	$315,956,447
2	VRTX	Vertex Pharmaceuticals Inc / Ma	553,243	$247,045,129
3	ALNY	Alnylam Pharmaceuticals, Inc.	662,365	$219,156,707
4	BBIO	BridgeBio Pharma, Inc.	1,977,080	$146,817,960
5	JAZZ	Jazz Pharmaceuticals plc	535,062	$101,153,471
6	ARGX	Argenx SE	49,330	$36,023,232
7	PTCT	Ptc Therapeutics, Inc.	425,240	$28,971,601
8	AXSM	Axsome Therapeutics, Inc.	117,093	$19,791,058

9 filing rows on record

Report Date	Value (USD)	Shares	Change	Type	Discretion	Filed
2026-03-31	$5,691,700	112,841	-12.5%	Shares	Defined	2026-05-15
2025-12-31	$4,226,465	129,013	+79.3%	Shares	Defined	2026-02-13
2025-09-30	$1,205,848	71,948	-9.9%	Shares	Defined	2025-11-14
2025-06-30	$1,196,043	79,896	+48.2%	Shares	Defined	2025-08-14
2025-03-31	$869,692	53,901	+2.2%	Shares	Defined	2025-05-15
2024-12-31	$1,228,299	52,762	+21.4%	Shares	Defined	2025-02-14
2024-09-30	$1,278,158	43,460	+15.0%	Shares	Defined	2024-11-13
2024-06-30	$888,254	37,782	+53.2%	Shares	Defined	2024-08-14
2024-03-31	$935,240	24,657	—	Shares	Defined	2024-05-14
No filing history on record for this holder in this stock.