Siren, L.L.C.
Filing Date
Global Rank
#895
/ 8,819
▲ 92
Top Industry
Biotechnology
92.3%
Period ended 4 months ago
Filed Aug 13, 2026 · 3mo
8 quarters · since Sep 2024
Regulatory profile
From Form ADV, the SEC filer profile, 13D/13G type codes and N-CEN, never from the name.
Holder type
Unknown
Continues the 13F reports of
Invus Financial Advisors, LLC
from Sep 30, 2024
Portfolio style
Measured from the filed 13F common-share book for Jun 30, 2026, never from the firm's own description.
Style
Diversified active
Top 10 weight 44.8%, 31.3 effective positions, active share 95.7% against the Russell 2000 as of 2026-06-30; it meets none of the index-like, systematic-like or concentrated tests
Turnover
Medium turnover
42.0% over the last four quarters (30% to under 100%)
Horizon
Medium horizon
Value-weighted holding period 6.1 quarters (4 to under 12)
Closest benchmark: the Russell 2000 as of 2026-06-30, active share 95.7%; sector active share 84.1% against the combined 13F book's sector weights.
Over time 8 measured quarters
How the bands are measured
Style bands measure the filed 13F common-share book each closed quarter, tested in this order. Unknown: under $10,000,000 of valued equity or 5 stocks. Index-like (100+ stocks): active share of 20% or less against the closest benchmark, which is the S&P 500, S&P MidCap 400, S&P SmallCap 600, Russell 1000, Russell 2000, Nasdaq-100 or Dow Jones Industrial Average (weighted by an index-tracking fund's reported holdings or the index's constituents nearest the quarter end, over the names resolved to companies, and only when those are 90%+ of its weight) or every 13F filer's combined book, or index series holding 80%+ of the registered fund assets it advises (N-CEN) and equal to 50%+ of its book. Systematic-like: 500+ stocks, 100%+ annual turnover and a top 10 weight of 25% or less. Concentrated: a top 10 weight of 60%+ or 12 or fewer effective positions. Diversified active: none of these. Turnover is the smaller of buys and sells over average equity value, summed over four quarters: low under 30%, high 100%+. Horizon is the value-weighted number of quarters each position has been held: short under 4, long 12+.
Clone Performance
Build a hypothetical price-return history from this filer's public 13F holdings.
View clone backtestPortfolio Concentration
116 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026Top Position
10.7%
−4.1 pts
Top 5
29.7%
−5.1 pts
Top 10
44.6%
−5.1 pts
HHI
318
Diversified−112
Portfolio Trend
8 quarters · across all stocks
Sector Breakdown
As of Jun 30, 2026| Sector | % Portfolio | Value |
|---|---|---|
| Healthcare | 92.9% | $4,592,495,357 |
| Technology | 3.9% | $191,960,034 |
| Communication Services | 1.9% | $91,465,290 |
| Financial Services | 0.9% | $42,766,151 |
| Consumer Cyclical | 0.4% | $21,263,750 |
| Real Estate | 0.0% | $1,453,000 |
Last Quarter's Activity
Export CSVAdded To
Positions the filer increased
25 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| ELVN | Enliven Therapeutics, Inc. | +1,028,185 | 1,774,411 | $90,051,358 | |
| TSHA | Taysha Gene Therapies, Inc. | +1,016,666 | 9,846,579 | $67,055,202 | |
| ENGN | enGene Therapeutics Inc. | +1,003,503 | 6,256,662 | $10,824,025 | |
| IVVD | Invivyd, Inc. | +1,000,000 | 5,000,000 | $4,360,000 | |
| CGEM | Cullinan Therapeutics, Inc. | +700,000 | 1,893,410 | $34,478,996 | |
| ABSI | Absci Corp | +674,764 | 2,474,764 | $28,682,514 | |
| TNGX | Tango Therapeutics, Inc. | +522,259 | 6,179,364 | $193,166,918 | |
| ANNX | Annexon, Inc. | +500,000 | 4,458,646 | $25,458,868 | |
| DFTX | Definium Therapeutics, Inc. | +500,000 | 1,419,493 | $66,772,950 | |
| RYTM | Rhythm Pharmaceuticals, Inc. | +410,764 | 1,136,275 | $126,160,613 | |
| SLN | Silence Therapeutics plc | +400,000 | 3,311,438 | $36,359,589 | |
| SION | Sionna Therapeutics, Inc. | +310,515 | 610,515 | $26,856,554 | |
| WHWK | Whitehawk Therapeutics, Inc. | +255,102 | 2,337,102 | $10,703,927 | |
| AMLX | Amylyx Pharmaceuticals, Inc. | +250,586 | 1,480,586 | $26,591,324 | |
| ERAS | Erasca, Inc. | +153,535 | 11,397,781 | $208,807,347 | |
| SYRE | Spyre Therapeutics, Inc. | +150,000 | 968,598 | $85,992,130 | |
| COGT | Cogent Biosciences, Inc. | +150,000 | 1,859,279 | $71,954,097 | |
| MANE | Veradermics, Inc | +150,000 | 1,655,374 | $203,511,679 | |
| CYTK | Cytokinetics Inc | +145,000 | 758,952 | $64,655,120 | |
| IREN | IREN Ltd | +131,900 | 175,000 | $8,002,750 | |
| ARWR | Arrowhead Pharmaceuticals, Inc. | +100,000 | 1,715,476 | $139,828,448 | |
| OLMA | Olema Pharmaceuticals, Inc. | +100,000 | 4,856,949 | $60,760,431 | |
| AEVA | Aeva Technologies, Inc. | +35,459 | 145,459 | $4,177,582 | |
| GTLB | Gitlab Inc. | +25,000 | 125,000 | $3,816,250 | |
| GOOGL | Alphabet Inc. | +24,297 | 90,000 | $32,163,300 | |
| No positions match the current search. | |||||
Trimmed
Positions the filer reduced
21 positions
| Ticker | Company | Δ Shares | Shares | Value | Open |
|---|---|---|---|---|---|
| TBLA | Taboola.com Ltd. | −1,546,085 | 8,423,410 | $42,117,050 | |
| SRRK | Scholar Rock Holding Corp | −1,250,000 | 9,575,013 | $526,625,715 | |
| EWTX | Edgewise Therapeutics, Inc. | −1,245,634 | 3,184,629 | $129,391,476 | |
| NBP | NovaBridge Biosciences | −995,261 | 2,004,739 | $3,909,241 | |
| RCUS | Arcus Biosciences, Inc. | −586,647 | 2,420,430 | $74,621,856 | |
| — | −482,848 | 1,420,788 | $53,165,886 | ||
| GPCR | Structure Therapeutics Inc. | −455,731 | 872,967 | $46,852,138 | |
| KYMR | Kymera Therapeutics, Inc. | −251,000 | 2,935,830 | $336,651,626 | |
| RVMD | Revolution Medicines, Inc. | −210,980 | 900,000 | $168,552,000 | |
| BCAX | Bicara Therapeutics Inc. | −200,000 | 5,602,970 | $166,352,179 | |
| SEPN | Septerna, Inc. | −100,000 | 1,900,000 | $63,631,000 | |
| DYN | Dyne Therapeutics, Inc. | −100,000 | 2,129,125 | $47,287,866 | |
| IRON | Disc Medicine, Inc. | −100,000 | 888,401 | $64,977,649 | |
| NBIS | Nebius Group N.V. | −61,614 | 52,000 | $14,360,840 | |
| WK | Workiva Inc | −47,500 | 45,000 | $2,182,950 | |
| FROG | JFrog Ltd | −33,316 | 95,500 | $8,679,040 | |
| TSLA | Tesla, Inc. | −18,000 | 3,500 | $1,472,100 | |
| DDOG | Datadog, Inc. | −14,300 | 40,000 | $10,414,400 | |
| AMZN | Amazon Com Inc | −14,141 | 32,500 | $7,746,050 | |
| CRWD | CrowdStrike Holdings, Inc. | −13,070 | 10,000 | $7,631,400 | |
| MSFT | Microsoft Corp | −3,880 | 37,500 | $13,988,250 | |
| No positions match the current search. | |||||
New Positions
Positions the filer opened this quarter
24 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| PBLS | Parabilis Medicines, Inc. | 2,992,259 | $81,898,128 | |
| ABVX | Abivax S.A. | 576,000 | $76,757,760 | |
| COAG | Hemab Therapeutics Holdings, Inc. | 2,086,834 | $76,649,412 | |
| RLAY | Relay Therapeutics, Inc. | 3,650,000 | $68,291,500 | |
| KLRA | Kailera Therapeutics, Inc. | 2,214,286 | $48,780,720 | |
| COF | Capital One Financial Corp | 171,615 | $34,429,401 | |
| ORKA | Oruka Therapeutics, Inc. | 250,000 | $23,792,500 | |
| SPTX | Seaport Therapeutics, Inc. | 1,095,316 | $23,790,263 | |
| TYRA | Tyra Biosciences, Inc. | 725,000 | $23,156,500 | |
| ADAG | Adagene Inc. | 2,666,666 | $11,199,997 | |
| OCS | Oculis Holding AG | 625,000 | $8,668,750 | |
| DSGN | Design Therapeutics, Inc. | 523,212 | $7,570,877 | |
| ELOX | Eloxx Pharmaceuticals, Inc. | 400,000 | $5,552,000 | |
| BABA | Alibaba Group Holding Ltd | 50,000 | $4,799,000 | |
| OUST | Ouster, Inc. | 67,500 | $4,220,100 | |
| PALI | Palisade Bio, Inc. | 2,000,000 | $4,180,000 | |
| ODTX | Odyssey Therapeutics, Inc. | 200,000 | $3,742,000 | |
| ZTS | Zoetis Inc. | 35,000 | $2,515,100 | |
| NFLX | Netflix Inc | 25,000 | $1,785,000 | |
| QNT | Quantinuum Inc. | 20,000 | $1,634,800 | |
| ENTX | Entera Bio Ltd. | 736,457 | $1,303,528 | |
| LITE | Lumentum Holdings Inc. | 1,055 | $905,253 | |
| FOXA | Fox Corp | 10,000 | $521,600 | |
| T | At&T Inc. | 25,000 | $517,500 | |
| No positions match the current search. | ||||
Sold Out
Positions the filer fully exited
9 positions
| Ticker | Company | Shares | Value | Open |
|---|---|---|---|---|
| CNTA | Centessa Pharmaceuticals plc | 1,053,464 | $41,843,590 | |
| FULC | Fulcrum Therapeutics, Inc. | 2,350,000 | $18,024,500 | |
| WVE | Wave Life Sciences, Inc. | 2,450,000 | $17,762,500 | |
| QURE | uniQure N.V. | 1,000,000 | $16,350,000 | |
| BCYC | Bicycle Therapeutics PLC | 1,560,882 | $7,242,492 | |
| FPS | Forgent Power Solutions, Inc. | 100,000 | $2,927,000 | |
| MU | Micron Technology Inc | 6,000 | $2,027,040 | |
| AS | Amer Sports, Inc. | 50,000 | $1,646,000 | |
| PRMB | Primo Brands Corp | 50,000 | $941,500 | |
| No positions match the current search. | ||||
116 tracked positions ·
$4,941,403,582 total
· filing declares
119 positions · $4,941,404,255
· as of Jun 30, 2026
All sectors
Communication Services
Consumer Cyclical
Financial Services
Healthcare
Real Estate
Technology
Showing 1–50
of 116 positions by value
· page 1 of 3
| Ticker | Company | Type | Shares | Value (USD) | % of Portfolio | History |
|---|---|---|---|---|---|---|
| SRRK |
Scholar Rock Holding Corp
Healthcare
|
Reduced | 9,575,013 | $526,625,715 | 10.66% | |
| KYMR |
Kymera Therapeutics, Inc.
Healthcare
|
Reduced | 2,935,830 | $336,651,626 | 6.81% | |
| ERAS |
Erasca, Inc.
Healthcare
|
Added | 11,397,781 | $208,807,347 | 4.23% | |
| MANE |
Veradermics, Inc
Healthcare
|
Added | 1,655,374 | $203,511,679 | 4.12% | |
| TNGX |
Tango Therapeutics, Inc.
Healthcare
|
Added | 6,179,364 | $193,166,918 | 3.91% | |
| RVMD |
Revolution Medicines, Inc.
Healthcare
|
Reduced | 900,000 | $168,552,000 | 3.41% | |
| BCAX |
Bicara Therapeutics Inc.
Healthcare
|
Reduced | 5,602,970 | $166,352,179 | 3.37% | |
| ARWR |
Arrowhead Pharmaceuticals, Inc.
Healthcare
|
Added | 1,715,476 | $139,828,448 | 2.83% | |
| ONC |
BeOne Medicines Ltd.
Healthcare
|
Held | 465,000 | $132,511,050 | 2.68% | |
| EWTX |
Edgewise Therapeutics, Inc.
Healthcare
|
Reduced | 3,184,629 | $129,391,476 | 2.62% | |
| RYTM |
Rhythm Pharmaceuticals, Inc.
Healthcare
|
Added | 1,136,275 | $126,160,613 | 2.55% | |
| LXRX |
Lexicon Pharmaceuticals, Inc.
Healthcare
|
Held | 44,303,518 | $106,328,443 | 2.15% | |
| ELVN |
Enliven Therapeutics, Inc.
Healthcare
|
Added | 1,774,411 | $90,051,358 | 1.82% | |
| SYRE |
Spyre Therapeutics, Inc.
Healthcare
|
Added | 968,598 | $85,992,130 | 1.74% | |
| PBLS |
Parabilis Medicines, Inc.
Healthcare
|
NEW | 2,992,259 | $81,898,128 | 1.66% | |
| XENE |
Xenon Pharmaceuticals Inc.
Healthcare
|
Held | 1,318,564 | $79,588,523 | 1.61% | |
| SLDB |
Solid Biosciences Inc.
Healthcare
|
Held | 7,690,405 | $76,827,145 | 1.55% | |
| ABVX |
Abivax S.A.
Healthcare
|
NEW | 576,000 | $76,757,760 | 1.55% | |
| COAG |
Hemab Therapeutics Holdings, Inc.
Healthcare
|
NEW | 2,086,834 | $76,649,412 | 1.55% | |
| RCUS |
Arcus Biosciences, Inc.
Healthcare
|
Reduced | 2,420,430 | $74,621,856 | 1.51% | |
| COGT |
Cogent Biosciences, Inc.
Healthcare
|
Added | 1,859,279 | $71,954,097 | 1.46% | |
| RLAY |
Relay Therapeutics, Inc.
Healthcare
|
NEW | 3,650,000 | $68,291,500 | 1.38% | |
| TSHA |
Taysha Gene Therapies, Inc.
Healthcare
|
Added | 9,846,579 | $67,055,202 | 1.36% | |
| DFTX |
Definium Therapeutics, Inc.
Healthcare
|
Added | 1,419,493 | $66,772,950 | 1.35% | |
| STOK |
Stoke Therapeutics, Inc.
Healthcare
|
Held | 1,995,347 | $65,287,753 | 1.32% | |
| IRON |
Disc Medicine, Inc.
Healthcare
|
Reduced | 888,401 | $64,977,649 | 1.31% | |
| CYTK |
Cytokinetics Inc
Healthcare
|
Added | 758,952 | $64,655,120 | 1.31% | |
| SEPN |
Septerna, Inc.
Healthcare
|
Reduced | 1,900,000 | $63,631,000 | 1.29% | |
| OLMA |
Olema Pharmaceuticals, Inc.
Healthcare
|
Added | 4,856,949 | $60,760,431 | 1.23% | |
|
|
Reduced | 1,420,788 | $53,165,886 | 1.08% | ||
| KLRA |
Kailera Therapeutics, Inc.
Healthcare
|
NEW | 2,214,286 | $48,780,720 | 0.99% | |
| DYN |
Dyne Therapeutics, Inc.
Healthcare
|
Reduced | 2,129,125 | $47,287,866 | 0.96% | |
| GPCR |
Structure Therapeutics Inc.
Healthcare
|
Reduced | 872,967 | $46,852,138 | 0.95% | |
| TBLA |
Taboola.com Ltd.
Communication Services
|
Reduced | 8,423,410 | $42,117,050 | 0.85% | |
| PVLA |
Palvella Therapeutics, Inc.
Healthcare
|
Held | 257,485 | $39,348,857 | 0.80% | |
| SLN |
Silence Therapeutics plc
Healthcare
|
Added | 3,311,438 | $36,359,589 | 0.74% | |
| DNLI |
Denali Therapeutics Inc.
Healthcare
|
Held | 1,396,513 | $35,918,314 | 0.73% | |
| RELY |
Remitly Global, Inc.
Technology
|
Held | 1,543,271 | $34,584,703 | 0.70% | |
| CGEM |
Cullinan Therapeutics, Inc.
Healthcare
|
Added | 1,893,410 | $34,478,996 | 0.70% | |
| COF |
Capital One Financial Corp
Financial Services
|
NEW | 171,615 | $34,429,401 | 0.70% | |
| TRVI |
Trevi Therapeutics, Inc.
Healthcare
|
Held | 1,786,867 | $33,325,069 | 0.67% | |
| ORIC |
Oric Pharmaceuticals, Inc.
Healthcare
|
Held | 2,998,192 | $32,470,419 | 0.66% | |
| GOOGL |
Alphabet Inc.
Communication Services
|
Added | 90,000 | $32,163,300 | 0.65% | |
| DBVT |
DBV Technologies S.A.
Healthcare
|
Held | 1,857,362 | $30,460,736 | 0.62% | |
| ABSI |
Absci Corp
Healthcare
|
Added | 2,474,764 | $28,682,514 | 0.58% | |
| SION |
Sionna Therapeutics, Inc.
Healthcare
|
Added | 610,515 | $26,856,554 | 0.54% | |
| RAPP |
Rapport Therapeutics, Inc.
Healthcare
|
Held | 641,469 | $26,730,013 | 0.54% | |
| AMLX |
Amylyx Pharmaceuticals, Inc.
Healthcare
|
Added | 1,480,586 | $26,591,324 | 0.54% | |
| ANNX |
Annexon, Inc.
Healthcare
|
Added | 4,458,646 | $25,458,868 | 0.52% | |
| MNPR |
Monopar Therapeutics
Healthcare
|
Held | 270,118 | $25,010,225 | 0.51% |
Showing the top 50 of 116 positions. Create a free account to see every position, past quarters, search, filters and CSV export.
Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.