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AMLX · Amylyx Pharmaceuticals, Inc.

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$18.50 +1.05 (+6.02%) At close · Jul 21
Market Cap
$2.06B
Shares
111.19M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

The Jun 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out.
Holders: 173
Total Value: $1,581,972,863
Total Shares: 113,782,056
Showing 1–100 of 182 holdings by value · page 1 of 2

Institutional Ownership Trend

18 quarters

Holder Concentration

Across 172 13F filers
Top Holder
14.6%
Jun 2023 → Mar 2026 · range 8.2% – 14.7%
of institutional value
Top 5
40.1%
Jun 2023 → Mar 2026 · range 27.6% – 40.7%
of institutional value
Top 10
57.9%
Jun 2023 → Mar 2026 · range 42.9% – 59.4%
of institutional value
HHI
499
Jun 2023 → Mar 2026 · range 281 – 510
Broadly held
Showing 100 of 182
All Common Calls Puts
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Holder Value (USD) % of 13F Shares Open
Mega FMR LLC $231,164,518 14.61% 16,630,541
Mega BlackRock, Inc. $122,720,815 7.76% 8,828,836
Mid PERCEPTIVE ADVISORS LLC $115,159,859 7.28% 8,284,882
Mid TCG Crossover Management, LLC $86,788,986 5.49% 6,243,812
Mid Commodore Capital LP $78,535,000 4.96% 5,650,000
Mega JANUS HENDERSON GROUP PLC $69,306,414 4.38% 4,986,073
Small Saturn V Capital Management LP $60,463,401 3.82% 4,349,885
Mega VANGUARD CAPITAL MANAGEMENT LLC $57,567,892 3.64% 4,141,575
Large ADAGE CAPITAL PARTNERS GP, L.L.C. $49,494,619 3.13% 3,560,764
Mid First Light Asset Management, LLC $44,349,965 2.80% 3,190,645
Large Driehaus Capital Management LLC $41,521,343 2.62% 2,987,147
Mega GOLDMAN SACHS GROUP INC $36,501,274 2.31% 2,625,991
Mega STATE STREET CORP $32,847,937 2.08% 2,363,161
Mega FRANKLIN RESOURCES INC $31,435,808 1.99% 2,261,569
Mega GEODE CAPITAL MANAGEMENT, LLC $30,731,954 1.94% 2,210,932
Mega MORGAN STANLEY $30,240,100 1.91% 2,175,547
Small Almitas Capital LLC $29,504,098 1.87% 2,122,597
Small GREAT POINT PARTNERS LLC $24,325,000 1.54% 1,750,000
Small Jones Hill Capital LP $22,223,236 1.40% 1,598,794
Mid 683 Capital Management, LLC $21,267,000 1.34% 1,530,000
Mid EVENTIDE ASSET MANAGEMENT, LLC $21,044,016 1.33% 1,513,958
Mega BANK OF AMERICA CORP /DE/ Bank $18,496,576 1.17% 1,330,689
Mega DEUTSCHE BANK AG\ Bank $17,622,210 1.11% 1,267,785
Mid Siren, L.L.C. $17,097,000 1.08% 1,230,000
Large Balyasny Asset Management L.P. $15,391,066 0.97% 1,107,271
Mid ADAR1 Capital Management, LLC $13,908,395 0.88% 1,000,604
Mega BARCLAYS PLC $13,508,770 0.85% 971,854
Mega DIMENSIONAL FUND ADVISORS LP $12,554,366 0.79% 903,192
Large Connor, Clark & Lunn Investment Management Ltd. $12,069,717 0.76% 868,325
Large Woodline Partners LP $11,756,620 0.74% 845,800
Small Boxer Capital Management, LLC $11,120,000 0.70% 800,000
Mega NORTHERN TRUST CORP Bank $10,840,720 0.69% 779,908
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $9,955,527 0.63% 716,225
Large Qube Research & Technologies Ltd $9,761,080 0.62% 702,236
Mid Logos Global Management LP $9,730,000 0.62% 700,000
Small STEMPOINT CAPITAL LP $9,308,621 0.59% 669,685
Small Parkman Healthcare Partners LLC $8,638,266 0.55% 621,458
Large JUPITER ASSET MANAGEMENT LTD $8,237,890 0.52% 592,654
Mega VANGUARD FIDUCIARY TRUST CO Bank $8,147,512 0.52% 586,152
Mid Nantahala Capital Management, LLC $7,446,007 0.47% 535,684
Mid Rock Springs Capital Management LP $6,946,719 0.44% 499,764
Mega CITADEL ADVISORS LLC $5,720,293 0.36% 411,532
Large FEDERATED HERMES, INC. $5,053,289 0.32% 363,546
Small HighVista Strategies LLC $4,893,981 0.31% 352,085
Mid Cormorant Asset Management, LP $4,865,000 0.31% 350,000
Mega UBS Group AG $4,508,033 0.28% 324,319
Small Tetragon Partners GP Ltd $4,418,490 0.28% 317,877
Mid iA Global Asset Management Inc. $4,236,525 0.27% 304,786
Mega Nuveen, LLC $3,682,067 0.23% 264,897
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $3,529,210 0.22% 253,900
Mega Bank of New York Mellon Corp Bank $3,490,343 0.22% 251,104
Mega WELLINGTON MANAGEMENT GROUP LLP $3,357,571 0.21% 241,552
Mid SummitTX Capital, L.P. $3,155,439 0.20% 227,010
Small Aldebaran Capital, LLC $2,750,698 0.17% 197,892
Mega Invesco Ltd. $2,385,517 0.15% 171,620
Mega TWO SIGMA INVESTMENTS, LP $2,251,035 0.14% 161,945
Mega JPMORGAN CHASE & CO $2,219,314 0.14% 159,663
Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $2,183,535 0.14% 157,089
Small ACUTA CAPITAL PARTNERS, LLC $2,099,831 0.13% 151,067
Small PFM Health Sciences, LP $2,019,322 0.13% 145,275
Small Alpha Wave Global, LP $1,978,470 0.13% 142,336
Mega Swiss National Bank Bank $1,811,170 0.11% 130,300
Mega PRICE T ROWE ASSOCIATES INC /MD/ $1,688,002 0.11% 121,439
Large Squarepoint Ops LLC $1,596,790 0.10% 114,877
Small Elmind Capital, LP $1,556,800 0.10% 112,000
Mega RHUMBLINE ADVISERS $1,507,691 0.10% 108,467
Large Point72 Asset Management, L.P. $1,480,836 0.09% 106,535
Mid 683 Capital Management, LLC $1,342,740 0.08% 96,600
Large ALPS ADVISORS INC $1,250,763 0.08% 89,983
Large SEI INVESTMENTS CO $1,185,378 0.07% 85,279
Mega ALLIANCEBERNSTEIN L.P. $1,123,120 0.07% 80,800
Large Schonfeld Strategic Advisors LLC $1,081,336 0.07% 77,794
Mega WELLS FARGO & COMPANY/MN $1,043,653 0.07% 75,083
Small Moody Aldrich Partners LLC $1,038,123 0.07% 57,802
Mega D. E. Shaw & Co., Inc. $1,031,796 0.07% 74,230
Large STATE OF WISCONSIN INVESTMENT BOARD $1,001,647 0.06% 72,061
Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Pension $903,527 0.06% 65,002
Large Walleye Capital LLC $857,782 0.05% 61,711
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $838,170 0.05% 60,300
Large Russell Investments Group, Ltd. $824,907 0.05% 59,346
Mega Legal & General Group Plc $775,243 0.05% 55,773
Mid Campbell & CO Investment Adviser LLC $756,465 0.05% 54,422
Small Informed Momentum Co LLC $740,258 0.05% 53,256
Large MetLife Investment Management, LLC $717,059 0.05% 51,587
Small Maven Securities LTD Broker-Dealer $695,000 0.04% 50,000
Small Numerai GP LLC $674,886 0.04% 48,553
Mega Vanguard Global Advisers, LLC $665,128 0.04% 47,851
Mega CITADEL ADVISORS LLC $629,670 0.04% 45,300
Mega VANGUARD ASSET MANAGEMENT, Ltd $601,633 0.04% 43,283
Large MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. Mutual Fund $591,486 0.04% 42,553
Large Zurcher Kantonalbank (Zurich Cantonalbank) Bank $566,981 0.04% 40,790
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $553,247 0.03% 39,802
Mega MANUFACTURERS LIFE INSURANCE COMPANY, THE Insurance $539,055 0.03% 38,781
Small Optimize Financial Inc $444,813 0.03% 32,001
Mega CITIGROUP INC $441,769 0.03% 31,782
Large TUDOR INVESTMENT CORP ET AL $435,542 0.03% 31,334
Mega AQR CAPITAL MANAGEMENT LLC $404,335 0.03% 29,089
Small Integrated Quantitative Investments LLC $378,552 0.02% 27,234
Large GUGGENHEIM CAPITAL LLC $354,630 0.02% 25,513
Mid INTECH INVESTMENT MANAGEMENT LLC $346,401 0.02% 24,921
Key facts CIK 1658551 CUSIP 03237H101 13F (30d) 10 filings 10 filers Visit website Investor relations

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