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AMLX · Amylyx Pharmaceuticals, Inc. · Holdings

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$29.24 +0.47 (+1.62%)
Russell 2000 member Rebalance outlook locked
Market Cap
$3.22B
Shares
111.42M
Volume · Oct 21 192.69K Avg daily vol (3M) 2.32M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP → See every holder of AMLX: 13F, 13D and 13G, insiders and funds →
Institutional holdings are being reconciled with SEC filings. Holder totals and changes may be incomplete until reconciliation finishes.
The Sep 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out. Each fund's Change is measured against its own previous reported quarter, shown in the Reported column. Pick a completed quarter in the Quarter selector below to put every fund on one quarter and see the stock-wide activity breakdown.
Holders: 210
Total Value: $2,078,989,475
Total Shares: 115,712,659
Showing 1–100 of 223 holdings by value · page 1 of 3

Institutional Ownership Trend

19 quarters

Holder Concentration

Across 207 13F filers
Top Holder
14.5%
Sep 2023 → Jun 2026 · range 8.2% – 14.7%
of institutional value
Top 5
39.6%
Sep 2023 → Jun 2026 · range 27.6% – 40.7%
of institutional value
Top 10
57.1%
Sep 2023 → Jun 2026 · range 42.9% – 59.4%
of institutional value
HHI
486
Sep 2023 → Jun 2026 · range 281 – 510
Broadly held

Who Holds AMLX

Last 8 quarters through Sep 30, 2026 (filing window open)

Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.

Jun 30, 2026, the newest closed quarter: 206 filers, like-for-like change +0.6%; actively managed books -2.2%; index-like books +10.5%.

Holder type Share Filers Change
Registered adviser 46.3% 109 -6.9%
Exempt adviser 0.6% 2 -1.3%
Adviser 3.5% 7 +28.5%
Bank 6.0% 13 +10.1%
Insurer 0.0% 1 +7.0%
Broker-dealer 0.0% 1 new
Benefit plan 0.1% 3 +10.5%
Non-US 0.7% 8 -53.4%
Holding company 28.3% 8 +6.5%
Unknown 14.5% 54 +12.0%

The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.

How the mix is measured

Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.

Excluded 3 holders with no observed 2026-03-31 13F and 1 holder with no observed 2026-06-30 13F. Compared across CIK changes: JANUS HENDERSON GROUP PLC continues as Jupiter Topco LLC.

Conviction and Crowding

206 13F filers, quarter ended Jun 30, 2026

Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.

Conviction holders
5
2.43% of filers hold it in their top 10
Mar 31, 2026: 6
Holders above 5%
2
median weight 0.002%
Mar 31, 2026: 4
Crowding
—
holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice
Private-fund advisers
—
of shares outstanding
Institutional ownership
—
holders exceed shares outstanding: 13F filers report more shares than the cover-page count, which predates an issuance, is misstated, or misses shares lent and reported twice
Top 10 holders
57.4%
of 13F shares, Herfindahl 0.049
Active holders
-2.2%
like-for-like share change of active filers
5% stakes on record
5
0 13D, 5 13G (2 institutional, 3 passive, 0 exempt)
How long holders have held it value-weighted 9.0 quarters
Under 1 year 20.6% 1 to 3 years 48.5% 3 years or more 30.9% Since coverage start 0.000%

Managers in the top fifth by current three-year FundScore alpha were net buyers of $0 (0 buying, 0 selling).

Estimated Holder Cost Basis

Quarter ended Jun 30, 2026, on that quarter's share basis

Estimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.

Estimated avg cost
$9.72
estimated per share
Mar 31, 2026: $8.94
Quarter-end price
$17.96
implied by 13F values
Estimated gain or loss
+84.8%
price against the estimated cost
Estimated at a loss
0.042%
of costed 13F value

Estimated cost covers 93.0% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.

Shared Holders

Companies AMLX's active holders also own, quarter ended Jun 30, 2026
# Company Shared holders
1 TNGX Tango Therapeutics, Inc. 15
2 ELVN Enliven Therapeutics, Inc. 15
3 PHVS Pharvaris N.V. 13
4 CLDX Celldex Therapeutics, Inc. 14
5 DMRA Damora Therapeutics, Inc. 10
6 ZURA Zura Bio Ltd 9
7 SYRE Spyre Therapeutics, Inc. 14
8 RLAY Relay Therapeutics, Inc. 12
9 AVTX Avalo Therapeutics, Inc. 12
10 LBRX Lb Pharmaceuticals Inc 9

Shareholder Targets

13F filers that own its peers but not AMLX, quarter ended Jun 30, 2026

Found through its holder-overlap peers: TNGX, ELVN, PHVS, CLDX, DMRA, ZURA, SYRE, RLAY, AVTX, LBRX, COGT, OLMA, RACC, PCVX, IMVT, SLN, JATT, MBX, DBVT, ERAS. 539 filers in all.

# Filer In peers
1 RTW INVESTMENTS, LP Registered adviser, Diversified active $1,355,845,751 6 held
2 T. Rowe Price Investment Management, Inc. Adviser, Diversified active $1,242,350,571 6 held
3 Deep Track Capital, LP Adviser, Diversified active $1,229,280,967 10 held
4 Paradigm Biocapital Advisors LP Registered adviser, Concentrated $1,085,279,807 6 held
5 Polar Capital Holdings Plc Registered adviser, Diversified active $857,120,177 8 held
6 Frazier Life Sciences Management, L.P. Registered adviser, Concentrated $843,740,177 3 held
7 RA CAPITAL MANAGEMENT, L.P. Registered adviser, Concentrated $825,274,930 5 held
8 Venrock Adviser, LLC Registered adviser, Concentrated $817,995,136 7 held
9 FARALLON CAPITAL MANAGEMENT LLC Registered adviser, Diversified active $657,674,610 5 held
10 Kynam Capital Management, LP Registered adviser, Concentrated $646,086,167 6 held

Fund Ownership of AMLX by Fund Type

Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026

Index funds and index ETFs hold 12.68% of shares outstanding.

Fund type Of shares outstanding Shares
Index funds 2.78% 3,094,822
Index ETFs 9.90% 11,032,824
Active ETFs 0.49% 541,614
Active funds 19.86% 22,128,517
Unclassified 0.20% 225,585
All registered funds 33.23% 37,023,362
How fund types are measured

Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.

Holder type: Registered adviser 112 Exempt adviser 3 Adviser 7 Bank 13 Insurer 1 Broker-dealer 1 Benefit plan 3 Non-US 8 Holding company 8 Unknown 54
Showing 100 of 223
All Common Calls Puts
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Holder Value (USD) % of 13F Shares Open
FMR LLC $300,433,243 14.45% 16,727,909
BlackRock, Inc. $158,534,441 7.63% 8,827,085
PERCEPTIVE ADVISORS LLC $149,694,480 7.20% 8,334,882
TCG Crossover Management, LLC $112,138,863 5.39% 6,243,812
Commodore Capital LP $101,474,000 4.88% 5,650,000
Jupiter Topco LLC $94,040,391 4.52% 5,236,102
Saturn V Capital Management LP $83,048,853 3.99% 4,624,101
VANGUARD CAPITAL MANAGEMENT LLC $75,867,063 3.65% 4,224,224
MORGAN STANLEY $56,229,310 2.70% 3,130,808
Driehaus Capital Management LLC $54,543,981 2.62% 3,036,970
First Light Asset Management, LLC $54,297,677 2.61% 3,023,256
FRANKLIN RESOURCES INC $52,986,040 2.55% 2,950,225
GOLDMAN SACHS GROUP INC $51,333,971 2.47% 2,858,239
STATE STREET CORP $46,755,932 2.25% 2,603,337
GEODE CAPITAL MANAGEMENT, LLC $41,942,256 2.02% 2,335,315
ADAGE CAPITAL PARTNERS GP, L.L.C. $34,124,000 1.64% 1,900,000
JPMORGAN CHASE & CO $33,471,153 1.61% 1,863,650
Siren, L.L.C. $26,591,324 1.28% 1,480,586
EVENTIDE ASSET MANAGEMENT, LLC $23,842,546 1.15% 1,327,536
683 Capital Management, LLC $22,980,035 1.11% 1,279,512
VANGUARD PORTFOLIO MANAGEMENT LLC $19,065,150 0.92% 1,061,534
Alyeska Investment Group, L.P. $18,912,149 0.91% 1,053,015
Almitas Capital LLC $17,508,862 0.84% 974,881
DIMENSIONAL FUND ADVISORS LP $16,208,234 0.78% 902,463
Jones Hill Capital LP $16,057,281 0.77% 894,058
Woodline Partners LP $15,201,110 0.73% 846,387
NORTHERN TRUST CORP $14,938,048 0.72% 831,740
BANK OF AMERICA CORP /DE/ $14,760,263 0.71% 821,841
Boxer Capital Management, LLC $14,368,000 0.69% 800,000
Aberdeen Group plc $13,248,553 0.64% 737,670
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $13,021,538 0.63% 725,030
Connor, Clark & Lunn Investment Management Ltd. $12,949,195 0.62% 721,002
GREAT POINT PARTNERS LLC $12,572,000 0.60% 700,000
Balyasny Asset Management L.P. $12,302,133 0.59% 684,974
Qube Research & Technologies Ltd $12,237,746 0.59% 681,389
VANGUARD FIDUCIARY TRUST CO $11,190,480 0.54% 623,078
TWO SIGMA INVESTMENTS, LP $10,658,092 0.51% 593,435
DEUTSCHE BANK AG\ $10,020,547 0.48% 557,937
Rock Springs Capital Management LP $8,975,761 0.43% 499,764
ADAR1 Capital Management, LLC $8,879,028 0.43% 494,378
Nantahala Capital Management, LLC $8,740,844 0.42% 486,684
FEDERATED HERMES, INC. $8,301,201 0.40% 462,205
Nearwater Capital Markets, Ltd $7,633,000 0.37% 425,000
SUSQUEHANNA INTERNATIONAL GROUP, LLP $7,279,188 0.35% 405,300
Parkman Healthcare Partners LLC $7,162,124 0.34% 398,782
HighVista Strategies LLC $6,933,996 0.33% 386,080
STEMPOINT CAPITAL LP $6,902,099 0.33% 384,304
Logos Global Management LP $6,286,000 0.30% 350,000
Trexquant Investment LP $6,275,924 0.30% 349,439
Nuveen, LLC $5,936,156 0.29% 330,521
Ensign Peak Advisors, Inc $5,485,720 0.26% 305,441
iA Global Asset Management Inc. $5,455,996 0.26% 303,786
JANE STREET GROUP, LLC $5,380,187 0.26% 299,565
Tetragon Partners GP Ltd $5,350,750 0.26% 297,926
JUPITER ASSET MANAGEMENT LTD $4,937,994 0.24% 274,944
Bank of New York Mellon Corp $4,928,850 0.24% 274,435
UBS Group AG $4,882,981 0.23% 271,881
FIRST TRUST ADVISORS LP $4,572,382 0.22% 254,587
SummitTX Capital, L.P. $4,089,312 0.20% 227,690
WELLINGTON MANAGEMENT GROUP LLP $3,822,641 0.18% 212,842
Cormorant Asset Management, LP $3,592,000 0.17% 200,000
Aldebaran Capital, LLC $3,518,220 0.17% 195,892
Walleye Capital LLC $3,351,120 0.16% 186,588
ORBIMED ADVISORS LLC $3,293,864 0.16% 183,400
CITADEL ADVISORS LLC $3,209,200 0.15% 178,686
D. E. Shaw & Co., Inc. $3,130,158 0.15% 174,285
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $3,114,386 0.15% 173,407
ACUTA CAPITAL PARTNERS, LLC $3,019,345 0.15% 168,115
NORGES BANK $2,871,804 0.14% 159,900
Alpha Wave Global, LP $2,791,379 0.13% 155,422
PRICE T ROWE ASSOCIATES INC /MD/ $2,606,588 0.13% 145,133
Swiss National Bank $2,589,832 0.12% 144,200
PFM Health Sciences, LP $2,580,852 0.12% 143,700
Invesco Ltd. $2,513,357 0.12% 139,942
WELLS FARGO & COMPANY/MN $2,301,825 0.11% 128,164
AMERIPRISE FINANCIAL INC $2,253,692 0.11% 125,484
Lighthouse Investment Partners, LLC $2,207,445 0.11% 122,909
Ikarian Capital, LLC $2,110,300 0.10% 117,500
RHUMBLINE ADVISERS $2,028,043 0.10% 112,920
ALPS ADVISORS INC $2,019,548 0.10% 112,447
Elmind Capital, LP $2,011,520 0.10% 112,000
ALLIANCEBERNSTEIN L.P. $1,875,024 0.09% 104,400
Campbell & CO Investment Adviser LLC $1,813,295 0.09% 100,963
Affinity Asset Advisors, LLC $1,778,022 0.09% 98,999
683 Capital Management, LLC $1,734,936 0.08% 96,600
Russell Investments Group, Ltd. $1,572,826 0.08% 87,574
Quantinno Capital Management LP $1,452,066 0.07% 80,850
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $1,434,501 0.07% 79,872
1492 Capital Management LLC $1,432,327 0.07% 79,751
CITIGROUP INC $1,233,563 0.06% 68,684
Schonfeld Strategic Advisors LLC $1,199,799 0.06% 66,804
Y-Intercept (Hong Kong) Ltd $1,145,754 0.06% 39,373
STATE OF WISCONSIN INVESTMENT BOARD $1,100,552 0.05% 61,278
JANE STREET GROUP, LLC $1,079,396 0.05% 60,100
Corient Private Wealth LLC $1,065,423 0.05% 59,322
Moody Aldrich Partners LLC $1,038,123 0.05% 57,802
VANGUARD ASSET MANAGEMENT, Ltd $1,022,786 0.05% 56,948
Legal & General Group Plc $1,014,326 0.05% 56,477
BARCLAYS PLC $1,010,393 0.05% 56,258
MetLife Investment Management, LLC $1,000,372 0.05% 55,700

Showing the top 100 of 223 holders. Create a free account to see every holder, past quarters, search, filters and CSV export.

Key facts CIK 1658551 CUSIP 03237H101 13F (30d) 15 filings 15 filers Visit website Investor relations