Rock Springs Capital Management LP

CIK

1595725

Location

Baltimore, MD

Portfolio Value

Mid $1,692,833,901

Diversification

Diversified

Filing Date

Global Rank

#1,314 / 8,607 ▼ 86 · as of Mar 2026

Top Industry

Biotechnology 73.6%

3Y Alpha vs SPY

-28.5%

Period ended 3 months ago

Filed May 15, 2026 · 58d

25 quarters · since Mar 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

-25.0%

SPY

+75.2%

Annualised alpha

-29.7%

Max drawdown

−64.7%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

99 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

6.9%

+1.2 pts

Top 5

26.3%

+0.7 pts

Top 10

40.7%

−1.9 pts

HHI

257

Diversified−7

Portfolio Trend

25 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$1,692,833,901	99

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
HTFL	Heartflow, Inc.	+294,800	572,500	$13,928,925
ERAS	Erasca, Inc.	+151,759	1,103,469	$17,854,128
BSX	Boston Scientific Corp	+116,250	515,300	$32,335,075
PTCT	Ptc Therapeutics, Inc.	+99,919	161,798	$11,023,297
FOCL	Edap Tms SA	+91,500	1,378,000	$5,126,160
OLMA	Olema Pharmaceuticals, Inc.	+72,138	170,378	$2,540,335
BCAX	Bicara Therapeutics Inc.	+60,000	489,095	$9,728,099
DYN	Dyne Therapeutics, Inc.	+59,243	972,198	$17,625,949
MIRM	Mirum Pharmaceuticals, Inc.	+49,000	811,294	$74,947,339
ATEC	Alphatec Holdings, Inc.	+47,500	350,000	$3,808,000
ALKS	Alkermes plc.	+44,758	183,986	$6,505,744
OCUL	Ocular Therapeutix, Inc	+37,896	383,716	$3,250,074
MDGL	Madrigal Pharmaceuticals, Inc.	+31,381	170,999	$89,512,846
ELVN	Enliven Therapeutics, Inc.	+28,095	826,500	$32,398,800
CNTA	Centessa Pharmaceuticals plc	+27,813	351,828	$13,974,608
IRTC	iRhythm Holdings, Inc.	+26,750	261,750	$30,891,735
NBIX	Neurocrine Biosciences Inc	+24,950	150,450	$19,820,283
BBIO	BridgeBio Pharma, Inc.	+24,750	128,250	$9,523,845
PHVS	Pharvaris N.V.	+22,131	645,533	$18,236,307
ACRS	Aclaris Therapeutics, Inc.	+18,909	4,472,650	$16,772,437
PCVX	Vaxcyte, Inc.	+13,250	60,250	$3,501,127
APLS	Apellis Pharmaceuticals, Inc.	+12,250	162,750	$6,547,432
UNH	Unitedhealth Group Inc	+12,200	53,000	$14,341,270
MLYS	Mineralys Therapeutics, Inc.	+12,155	439,751	$11,912,854
SLNO	Soleno Therapeutics Inc	+10,200	257,253	$8,612,830
No positions match the current search.

Trimmed

Positions the filer reduced

24 positions

Ticker	Company	Δ Shares	Shares	Value
AGL	agilon health, inc.	−6,240,000	260,000	$2,056,600
FOLD	AMICUS THERAPEUTICS, INC.	−1,908,869	21,062	$304,556
GOSS	Gossamer Bio, Inc.	−1,657,468	1,609,492	$529,522
TVTX	Travere Therapeutics, Inc.	−732,368	1,477,954	$43,910,013
CMPX	Compass Therapeutics, Inc.	−621,894	3,305,308	$17,485,079
PHR	Phreesia, Inc.	−276,200	600,400	$5,031,352
COGT	Cogent Biosciences, Inc.	−224,875	624,155	$24,023,725
OMDA	Omada Health, Inc.	−199,000	541,000	$6,800,370
RVMD	Revolution Medicines, Inc.	−125,805	1,209,465	$117,620,471
CAI	Caris Life Sciences, Inc.	−124,500	563,000	$10,066,440
GPCR	Structure Therapeutics Inc.	−108,019	640,217	$30,858,459
SGRY	Surgery Partners, Inc.	−102,000	208,000	$2,479,360
VERA	Vera Therapeutics, Inc.	−64,994	503,585	$20,259,224
EW	Edwards Lifesciences Corp	−53,600	28,900	$2,314,312
RARE	Ultragenyx Pharmaceutical Inc.	−48,468	1,218,773	$25,533,294
ACHC	Acadia Healthcare Company, Inc.	−44,500	75,500	$1,765,945
CLDX	Celldex Therapeutics, Inc.	−42,268	650,270	$20,626,564
TARS	Tarsus Pharmaceuticals, Inc.	−35,165	225,179	$15,796,306
XENE	Xenon Pharmaceuticals Inc.	−24,768	763,020	$44,369,613
ASND	Ascendis Pharma A/S	−9,500	194,000	$44,373,620
LLY	ELI LILLY & Co	−6,700	98,700	$90,781,299
RYTM	Rhythm Pharmaceuticals, Inc.	−5,262	689,748	$59,987,383
INSM	INSMED Inc	−4,950	314,300	$51,394,336
ARGX	Argenx SE	−4,750	98,500	$71,929,625
No positions match the current search.

New Positions

Positions the filer opened this quarter

10 positions

Ticker	Company	Shares	Value
MMED	MiniMed Group, Inc.	1,055,000	$15,740,600
INDV	Indivior Pharmaceuticals, Inc.	200,000	$6,096,000
SYK	Stryker Corp	14,800	$4,863,132
NVO	Novo Nordisk A S	90,000	$3,307,500
VKTX	Viking Therapeutics, Inc.	96,000	$3,123,840
IPSC	Century Therapeutics, Inc.	1,304,347	$2,947,824
CVS	CVS HEALTH Corp	40,000	$2,872,800
DNTH	Dianthus Therapeutics, Inc. /DE/	26,757	$2,245,447
ORKA	Oruka Therapeutics, Inc.	4,123	$202,233
BCRX	Biocryst Pharmaceuticals Inc	12,600	$119,952
No positions match the current search.

Sold Out

Positions the filer fully exited

2 positions

Ticker	Company	Shares	Value
EXAS	EXACT SCIENCES CORP	601,800	$61,118,808
TBPH	Theravance Biopharma, Inc.	208,771	$3,906,105
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

99 positions · $1,692,833,901 total · as of Mar 31, 2026

All sectors Healthcare

Showing 1–50 of 99 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
RVMD	Revolution Medicines, Inc. Healthcare	Reduced	1,209,465	-125,805	$117,620,471	+10.6%	6.95%
LLY	ELI LILLY & Co Healthcare	Reduced	98,700	-6,700	$90,781,299	−19.9%	5.36%
MDGL	Madrigal Pharmaceuticals, Inc. Healthcare	Added	170,999	+31,381	$89,512,846	+10.1%	5.29%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	Added	811,294	+49,000	$74,947,339	+24.5%	4.43%
ARGX	Argenx SE Healthcare	Reduced	98,500	-4,750	$71,929,625	−17.2%	4.25%
RYTM	Rhythm Pharmaceuticals, Inc. Healthcare	Reduced	689,748	-5,262	$59,987,383	−19.4%	3.54%
INSM	INSMED Inc Healthcare	Reduced	314,300	-4,950	$51,394,336	−7.5%	3.04%
ASND	Ascendis Pharma A/S Healthcare	Reduced	194,000	-9,500	$44,373,620	+2.3%	2.62%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Reduced	763,020	-24,768	$44,369,613	+25.7%	2.62%
TVTX	Travere Therapeutics, Inc. Healthcare	Reduced	1,477,954	-732,368	$43,910,013	−48.0%	2.59%
KYMR	Kymera Therapeutics, Inc. Healthcare	Held	496,871	0	$41,384,385	+7.0%	2.44%
PEN	Penumbra Inc Healthcare	Held	120,500	0	$39,568,585	+5.6%	2.34%
ISRG	Intuitive Surgical Inc Healthcare	Held	82,000	0	$37,801,180	−18.6%	2.23%
SRRK	Scholar Rock Holding Corp Healthcare	Added	739,816	+6,339	$36,369,354	+12.6%	2.15%
ELVN	Enliven Therapeutics, Inc. Healthcare	Added	826,500	+28,095	$32,398,800	+163.5%	1.91%
BSX	Boston Scientific Corp Healthcare	Added	515,300	+116,250	$32,335,075	−15.0%	1.91%
IRTC	iRhythm Holdings, Inc. Healthcare	Added	261,750	+26,750	$30,891,735	−25.9%	1.82%
GPCR	Structure Therapeutics Inc. Healthcare	Reduced	640,217	-108,019	$30,858,459	−40.7%	1.82%
AGIO	Agios Pharmaceuticals, Inc. Healthcare	Held	799,163	0	$27,035,684	+24.3%	1.60%
RARE	Ultragenyx Pharmaceutical Inc. Healthcare	Reduced	1,218,773	-48,468	$25,533,294	−12.4%	1.51%
ALNY	Alnylam Pharmaceuticals, Inc. Healthcare	Added	74,000	+2,750	$24,484,380	−13.6%	1.45%
COGT	Cogent Biosciences, Inc. Healthcare	Reduced	624,155	-224,875	$24,023,725	−20.3%	1.42%
THC	Tenet Healthcare Corp Healthcare	Held	125,000	0	$23,588,750	−5.0%	1.39%
DXCM	Dexcom Inc Healthcare	Added	355,600	+8,300	$22,331,680	−3.1%	1.32%
CLDX	Celldex Therapeutics, Inc. Healthcare	Reduced	650,270	-42,268	$20,626,564	+9.7%	1.22%
VERA	Vera Therapeutics, Inc. Healthcare	Reduced	503,585	-64,994	$20,259,224	−29.6%	1.20%
NBIX	Neurocrine Biosciences Inc Healthcare	Added	150,450	+24,950	$19,820,283	+11.4%	1.17%
ACLX	Arcellx, Inc. Healthcare	Held	169,859	0	$19,503,210	+76.1%	1.15%
NAMS	NewAmsterdam Pharma Co N.V. Healthcare	Held	588,794	0	$18,847,295	−8.8%	1.11%
PHVS	Pharvaris N.V. Healthcare	Added	645,533	+22,131	$18,236,307	+5.4%	1.08%
ERAS	Erasca, Inc. Healthcare	Added	1,103,469	+151,759	$17,854,128	+404.3%	1.05%
DYN	Dyne Therapeutics, Inc. Healthcare	Added	972,198	+59,243	$17,625,949	−1.3%	1.04%
CMPX	Compass Therapeutics, Inc. Healthcare	Reduced	3,305,308	-621,894	$17,485,079	−17.1%	1.03%
ACRS	Aclaris Therapeutics, Inc. Healthcare	Added	4,472,650	+18,909	$16,772,437	+25.1%	0.99%
TARS	Tarsus Pharmaceuticals, Inc. Healthcare	Reduced	225,179	-35,165	$15,796,306	−25.9%	0.93%
MMED	MiniMed Group, Inc. Healthcare	NEW	1,055,000	NEW	$15,740,600	NEW	0.93%
ZLAB	Zai Lab Ltd Healthcare	Added	814,707	+3,161	$15,324,638	+7.0%	0.91%
UNH	Unitedhealth Group Inc Healthcare	Added	53,000	+12,200	$14,341,270	+6.5%	0.85%
CNTA	Centessa Pharmaceuticals plc Healthcare	Added	351,828	+27,813	$13,974,608	+72.4%	0.83%
HTFL	Heartflow, Inc. Healthcare	Added	572,500	+294,800	$13,928,925	+72.1%	0.82%
ARDX	Ardelyx, Inc. Healthcare	Held	2,299,473	0	$13,773,843	+2.7%	0.81%
SMMT	Summit Therapeutics Inc. Healthcare	Held	710,000	0	$13,461,600	+8.4%	0.80%
AZTA	Azenta, Inc. Healthcare	Held	569,100	0	$12,025,083	−36.5%	0.71%
MLYS	Mineralys Therapeutics, Inc. Healthcare	Added	439,751	+12,155	$11,912,854	−23.2%	0.70%
DHR	Danaher Corp /De/ Healthcare	Held	61,500	0	$11,660,400	−17.2%	0.69%
PTCT	Ptc Therapeutics, Inc. Healthcare	Added	161,798	+99,919	$11,023,297	+134.5%	0.65%
CAI	Caris Life Sciences, Inc. Healthcare	Reduced	563,000	-124,500	$10,066,440	−45.7%	0.59%
ZBIO	Zenas BioPharma, Inc. Healthcare	Held	502,077	0	$9,815,605	−46.2%	0.58%
BCAX	Bicara Therapeutics Inc. Healthcare	Added	489,095	+60,000	$9,728,099	+34.7%	0.57%
BBIO	BridgeBio Pharma, Inc. Healthcare	Added	128,250	+24,750	$9,523,845	+20.3%	0.56%