XBI · State Street(R) SPDR(R) S&P(R) Biotech ETF ETF
SPDR SERIES TRUST
$163.81
-0.35%
At close · Sep 4
Net assets $10,734,887,977
Holdings161
1 month
+4.09%
Year to date
+34.48%
52-week range
$92.64–$169.89
30-session avg volume
8,123,115
Market performance
Adjusted close · up to five years
Fund profile
- Structure
- Open-end / ETF
- SEC series
- S000010018
- Report date
- Jun 30, 2026
- Holdings coverage
- Full reported portfolio
Portfolio concentration
Top 10 holdings17.99%
Calculated only when the SEC filing is stored with complete portfolio coverage.
Asset allocation
EC99.86%
STIV5.91%
DE0.11%
Country allocation
US100.75%
IE1.24%
BM1.16%
NL1.03%
CH1.02%
VG0.53%
CA0.16%
Portfolio holdings
Latest linked SEC Form NPORT-P report.
| Holding | Ticker / CUSIP | Value | Weight |
|---|---|---|---|
| State Street Global Advisors | 857492706 | $630,641,937 | 5.87% |
| Apogee Therapeutics Inc | APGE | $159,763,650 | 1.49% |
| Moderna Inc | MRNA | $151,607,387 | 1.41% |
| Twist Bioscience Corp | TWST | $151,142,140 | 1.41% |
| Oruka Therapeutics Inc | ORKA | $147,989,540 | 1.38% |
| Kymera Therapeutics Inc | KYMR | $145,946,701 | 1.36% |
| Viking Therapeutics Inc | VKTX | $139,967,802 | 1.30% |
| Praxis Precision Medicines Inc | PRAX | $138,515,010 | 1.29% |
| Erasca Inc | ERAS | $136,432,063 | 1.27% |
| Revolution Medicines Inc | RVMD | $129,316,653 | 1.20% |
| Rhythm Pharmaceuticals Inc | RYTM | $128,980,442 | 1.20% |
| CG oncology Inc | CGON | $128,808,819 | 1.20% |
| SELLAS Life Sciences Group Inc | SLS | $127,743,667 | 1.19% |
| Vaxcyte Inc | PCVX | $127,427,471 | 1.19% |
| Dianthus Therapeutics Inc | DNTH | $127,007,959 | 1.18% |
| Cytokinetics Inc | CYTK | $126,461,659 | 1.18% |
| Natera Inc | NTRA | $124,849,899 | 1.16% |
| Scholar Rock Holding Corp | SRRK | $124,202,980 | 1.16% |
| Roivant Sciences Ltd | 000000000 | $124,029,493 | 1.16% |
| Mirum Pharmaceuticals Inc | MIRM | $124,001,246 | 1.16% |
| Cogent Biosciences Inc | COGT | $122,794,674 | 1.14% |
| Ultragenyx Pharmaceutical Inc | RARE | $122,436,723 | 1.14% |
| Travere Therapeutics Inc | TVTX | $121,012,969 | 1.13% |
| Alkermes PLC | 000000000 | $118,998,738 | 1.11% |
| Krystal Biotech Inc | KRYS | $118,466,467 | 1.10% |
| Celcuity Inc | CELC | $118,046,826 | 1.10% |
| Relay Therapeutics Inc | RLAY | $117,960,956 | 1.10% |
| Spyre Therapeutics Inc | SYRE | $117,725,387 | 1.10% |
| TG Therapeutics Inc | TGTX | $117,336,182 | 1.09% |
| Beam Therapeutics Inc | BEAM | $115,873,930 | 1.08% |
| Insmed Inc | INSM | $115,546,653 | 1.08% |
| Protagonist Therapeutics Inc | PTGX | $115,392,767 | 1.07% |
| Arrowhead Pharmaceuticals Inc | ARWR | $114,732,416 | 1.07% |
| Vera Therapeutics Inc | VERA | $113,719,524 | 1.06% |
| Vertex Pharmaceuticals Inc | VRTX | $113,490,387 | 1.06% |
| Madrigal Pharmaceuticals Inc | MDGL | $113,431,224 | 1.06% |
| AbbVie Inc | ABBV | $111,376,619 | 1.04% |
| Biogen Inc | BIIB | $110,742,849 | 1.03% |
| PTC Therapeutics Inc | PTCT | $110,728,502 | 1.03% |
| Halozyme Therapeutics Inc | HALO | $110,545,261 | 1.03% |
| uniQure NV | 000000000 | $110,376,388 | 1.03% |
| Bridgebio Pharma Inc | BBIO | $110,020,441 | 1.02% |
| CRISPR Therapeutics AG | 000000000 | $109,835,924 | 1.02% |
| ImmunityBio Inc | IBRX | $109,402,918 | 1.02% |
| Summit Therapeutics Inc | SMMT | $108,592,206 | 1.01% |
| Ionis Pharmaceuticals Inc | IONS | $107,676,771 | 1.00% |
| Incyte Corp | INCY | $107,116,358 | 1.00% |
| Amgen Inc | AMGN | $106,775,790 | 0.99% |
| Neurocrine Biosciences Inc | NBIX | $104,317,435 | 0.97% |
| Gilead Sciences Inc | GILD | $103,544,853 | 0.96% |