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Equibles

AGIO

Agios Pharmaceuticals, Inc.

Company with tickers: AGIO

CIK
1439222
CUSIP
00847X104
Shares Outstanding
59,471,609
13F Activity (30d)
156 filings 139 filers

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Holders: 235
Total Value: $2,269,384,337
Total Shares: 67,082,013
Showing 1–100 of 248 holdings by value · page 1 of 3

Institutional Ownership Trend

28 quarters

Holder Concentration

Across 235 13F filers · Δ vs Dec 31, 2025
Top Holder
8.8%
Mar 2024 → Mar 2026 · range 8.8% – 12.9%
−3.7 pts
Top 5
34.9%
Mar 2024 → Mar 2026 · range 34.9% – 50.1%
−6.5 pts
Top 10
53.0%
Mar 2024 → Mar 2026 · range 52.6% – 66.6%
−4.9 pts
HHI
385
Mar 2024 → Mar 2026 · range 385 – 631
Broadly held−99

Quarterly Activity

vs Dec 31, 2025
New
58
Increased
75
Decreased
70
Sold Out
38
Unchanged
32
Holder count: +20
Institutional value: +72.6%
Shares held: +38.9%

Top Buyers

vs Dec 31, 2025
Institution Added Now Holds Open
Small Lynx1 Capital Management LP +2,531,944 2,611,568
Mega D. E. Shaw & Co., Inc. +819,883 2,681,169
Large FARALLON CAPITAL MANAGEMENT LLC +524,495 5,684,000
Mega Nuveen, LLC +424,440 722,348
Small Parkman Healthcare Partners LLC +303,921 403,525

Top Sellers

vs Dec 31, 2025
Institution Sold Now Holds Open
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP −1,325,979 1,556,353
Mega CITADEL ADVISORS LLC −839,455 769,413
Mega Capital International Investors −655,249 48,616
Large Balyasny Asset Management L.P. −617,060 18,009
Mega BARCLAYS PLC −320,114 52,438

Top New Positions

vs Dec 31, 2025
Institution Acquired Value (USD) Open
Mega BlackRock, Inc. 5,754,957 $194,690,188
Mega VANGUARD CAPITAL MANAGEMENT LLC 2,632,316 $89,051,250
Mega VANGUARD PORTFOLIO MANAGEMENT LLC 2,611,035 $88,331,314
Mega T. Rowe Price Investment Management, Inc. 1,488,740 $50,364,074
Mega DIMENSIONAL FUND ADVISORS LP 1,151,614 $38,959,099

Top Sold-Out Positions

vs Dec 31, 2025
Institution Previously Held Last Value (USD) Open
Mid TCG Crossover Management, LLC 1,181,841 $32,169,712
Mid Ikarian Capital, LLC 252,689 $6,878,194
Mid MOORE CAPITAL MANAGEMENT, LP 150,000 $4,083,000
Large Allianz Asset Management GmbH 147,950 $4,027,199
Small HighVista Strategies LLC 147,662 $4,019,359
Filter: New 58 Increased 75 Reduced 70 Sold out 38 Unchanged 32
Showing 100 of 248
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Mega BlackRock, Inc. $194,690,188 8.58% 5,754,957
Large FARALLON CAPITAL MANAGEMENT LLC $192,289,720 8.47% 5,684,000
Mega STATE STREET CORP $113,833,856 5.02% 3,364,879
Mid ARMISTICE CAPITAL, LLC $108,256,000 4.77% 3,200,000
Mid ARMISTICE CAPITAL, LLC $91,882,280 4.05% 2,716,000
Large Erste Asset Management GmbH $91,506,767 4.03% 2,704,900
Mega D. E. Shaw & Co., Inc. $90,703,947 4.00% 2,681,169
Mega VANGUARD CAPITAL MANAGEMENT LLC $89,051,250 3.92% 2,632,316
Small Lynx1 Capital Management LP $88,349,345 3.89% 2,611,568
Mega VANGUARD PORTFOLIO MANAGEMENT LLC $88,331,314 3.89% 2,611,035
Large BNP PARIBAS ASSET MANAGEMENT Holding S.A. $53,479,816 2.36% 1,580,840
Large NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $50,556,736 2.23% 1,494,435
Mega T. Rowe Price Investment Management, Inc. $50,364,074 2.22% 1,488,740
Mega GEODE CAPITAL MANAGEMENT, LLC $49,659,395 2.19% 1,467,910
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $45,499,759 2.00% 1,344,953
Mid MPM BIOIMPACT LLC $44,190,809 1.95% 1,306,261
Mid Frazier Life Sciences Management, L.P. $42,493,186 1.87% 1,256,080
Large GW&K Investment Management, LLC $41,100,100 1.81% 1,214,901
Mega DIMENSIONAL FUND ADVISORS LP $38,959,099 1.72% 1,151,614
Mega MORGAN STANLEY $32,731,366 1.44% 967,525
Mega GOLDMAN SACHS GROUP INC $27,259,400 1.20% 805,776
Mid Rock Springs Capital Management LP $27,035,684 1.19% 799,163
Mega Nuveen, LLC $24,437,031 1.08% 722,348
Mega JANE STREET GROUP, LLC $23,181,668 1.02% 685,240
Mega WELLINGTON MANAGEMENT GROUP LLP $21,701,468 0.96% 641,486
Mega CITADEL ADVISORS LLC $20,961,506 0.92% 619,613
Mid SCS Capital Management LLC $20,732,715 0.91% 612,850
Small Foresite Capital Management VI LLC $17,760,750 0.78% 525,000
Mega NORTHERN TRUST CORP Bank $17,228,669 0.76% 509,272
Mega BANK OF AMERICA CORP /DE/ Bank $17,182,254 0.76% 507,900
Large Artisan Partners Limited Partnership $16,289,686 0.72% 481,516
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $16,137,992 0.71% 477,032
Large Connor, Clark & Lunn Investment Management Ltd. $15,226,646 0.67% 450,093
Mid Vestal Point Capital, LP $15,223,500 0.67% 450,000
Large MARSHALL WACE, LLP $15,159,830 0.67% 448,118
Mega Legal & General Group Plc $14,341,043 0.63% 423,915
Mid ArrowMark Colorado Holdings LLC $13,653,449 0.60% 403,590
Small Parkman Healthcare Partners LLC $13,651,250 0.60% 403,525
Mega VANGUARD FIDUCIARY TRUST CO Bank $12,923,770 0.57% 382,021
Mega BNP PARIBAS ARBITRAGE, SA $11,077,870 0.49% 327,457
Mega PRICE T ROWE ASSOCIATES INC /MD/ $10,107,828 0.45% 298,783
Mid KENNEDY CAPITAL MANAGEMENT LLC $9,318,676 0.41% 275,456
Mid ALGERT GLOBAL LLC $9,081,156 0.40% 268,435
Mega TWO SIGMA INVESTMENTS, LP $8,512,845 0.38% 251,636
Mega ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $8,473,095 0.37% 250,461
Large PANAGORA ASSET MANAGEMENT INC $8,067,372 0.36% 238,468
Small Palo Alto Investors LP $7,226,121 0.32% 213,601
Small Seven Fleet Capital Management LP $7,088,975 0.31% 209,547
Large Squarepoint Ops LLC $7,066,681 0.31% 208,888
Large Schonfeld Strategic Advisors LLC $6,768,063 0.30% 200,061
Mid Eversept Partners, LP $6,766,000 0.30% 200,000
Large HRT FINANCIAL LP $6,611,464 0.29% 195,432
Large Qube Research & Technologies Ltd $6,348,774 0.28% 187,667
Mega Bank of New York Mellon Corp Bank $6,319,136 0.28% 186,791
Mid GROUP ONE TRADING LLC $5,862,028 0.26% 173,279
Small Tetragon Partners GP Ltd $5,576,503 0.25% 164,839
Mid XTX Topco Ltd $5,442,570 0.24% 160,880
Mega JPMORGAN CHASE & CO $5,127,205 0.23% 151,558
Mega Invesco Ltd. $5,122,874 0.23% 151,430
Large Man Group plc $4,881,567 0.22% 144,297
Mid Edgestream Partners, L.P. $4,862,419 0.21% 143,731
Mid ADAR1 Capital Management, LLC $4,758,933 0.21% 140,672
Mega UBS Group AG $4,483,827 0.20% 132,540
Large CAPITAL FUND MANAGEMENT S.A. $4,382,033 0.19% 129,531
Large Pictet Asset Management Holding SA $4,357,777 0.19% 128,814
Small Exome Asset Management LLC $4,230,779 0.19% 125,060
Mega AMERICAN CENTURY COMPANIES INC $4,068,158 0.18% 120,253
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $3,954,727 0.17% 116,900
Mega UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $3,744,265 0.16% 110,679
Mega Swiss National Bank Bank $3,682,733 0.16% 108,860
Mega JANE STREET GROUP, LLC $3,623,193 0.16% 107,100
Small ESSEX INVESTMENT MANAGEMENT CO LLC $3,490,477 0.15% 103,177
Large Rafferty Asset Management, LLC $3,475,728 0.15% 102,741
Mid TANG CAPITAL MANAGEMENT LLC $3,383,000 0.15% 100,000
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $3,196,935 0.14% 94,500
Small Knott David M Jr $3,148,152 0.14% 93,058
Mid Caligan Partners LP $3,044,700 0.13% 90,000
Mega CITADEL ADVISORS LLC $2,845,103 0.13% 84,100
Large Trexquant Investment LP $2,547,331 0.11% 75,298
Large Woodline Partners LP $2,517,730 0.11% 74,423
Mega RHUMBLINE ADVISERS $2,482,073 0.11% 73,369
Large CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Pension $2,319,520 0.10% 68,564
Large Assenagon Asset Management S.A. $2,271,785 0.10% 67,153
Mega CITADEL ADVISORS LLC $2,222,631 0.10% 65,700
Large SEI INVESTMENTS CO $2,149,895 0.09% 63,550
Mega CITIGROUP INC $2,127,907 0.09% 62,900
Mega CITIGROUP INC $2,127,907 0.09% 62,900
Mega ALLIANCEBERNSTEIN L.P. $2,080,342 0.09% 61,494
Large Universal- Beteiligungs- und Servicegesellschaft mbH $2,052,770 0.09% 60,679
Small Headlands Technologies LLC $2,004,664 0.09% 59,257
Mega VANGUARD ASSET MANAGEMENT, Ltd $1,984,061 0.09% 58,648
Large TUDOR INVESTMENT CORP ET AL $1,967,248 0.09% 58,151
Large SG Americas Securities, LLC Broker-Dealer $1,936,666 0.09% 57,247
Mega BARCLAYS PLC $1,773,976 0.08% 52,438
Large Hudson Bay Capital Management LP $1,753,408 0.08% 51,830
Large NEW YORK STATE COMMON RETIREMENT FUND Pension $1,749,247 0.08% 51,707
Mega DEUTSCHE BANK AG\ Bank $1,704,490 0.08% 50,384
Mega MANUFACTURERS LIFE INSURANCE COMPANY, THE Insurance $1,693,056 0.07% 50,046
Mega JANE STREET GROUP, LLC $1,661,053 0.07% 49,100
Mega Capital International Investors $1,644,679 0.07% 48,616

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