AGIO · Agios Pharmaceuticals, Inc. · Shareholders & Ownership

$36.64 +1.74 (+4.99%) At close · Oct 20

Russell 2000 member Rebalance outlook locked

Market Cap

$2.18B

59.70M

Volume · Oct 20 1.52M Avg daily vol (3M) 1.13M

Every disclosed holder of AGIO in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.

How the holder list picks a filing →

Who Owns AGIO

13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positions

No chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.

Holder group	Holders	Shares	% Out	Summed
Institutional (13F)	238	67,873,919	113.69%	Yes
Insiders (Forms 3, 4, 5)	16	661,980	1.11%	Yes
13D/G-only blocks	2	8,033,060	13.46%	Yes
Remaining	—	16,867,077	-28.25%	Negative
Registered funds (N-PORT, not summed)	229	18,830,739	31.54%	No

Shares outstanding: 59,701,882, the issuer's latest cover-page count restated onto today's split basis.

Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.

13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.

Holders of AGIO

One row per holder Every filing By ultimate parent

All 13F Funds Insiders 13D/G Non-US

#	Holder	Shares	% Out	Change	As of	Notes
1	BlackRock, Inc. 13F CIK 2012383 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	6,455,997	10.81%	+701,040	Jun 30, 2026	carried, not yet filed for the newest quarter
1.1	iShares Russell 2000 ETF Fund S000004344 · Registered fund · Jun 30, 2026 iShares Trust, not summed	1,539,675	2.58%	+159,994	Jun 30, 2026	iShares Trust, not summed
1.2	iShares Russell 2000 Value ETF Fund S000004342 · Registered fund · Jun 30, 2026 iShares Trust, not summed	520,310	0.87%	+36,015	Jun 30, 2026	iShares Trust, not summed
1.3	iShares Biotechnology ETF Fund S000004350 · Registered fund · Jun 30, 2026 iShares Trust, not summed	395,471	0.66%	-4,616	Jun 30, 2026	iShares Trust, not summed
1.4	BlackRock Health Sciences Opportunities Portfolio Fund S000001877 · Registered fund · May 29, 2026 BlackRock Funds, not summed	271,615	0.46%	-73,261	May 29, 2026	BlackRock Funds, not summed
1.5	BlackRock Advantage Small Cap Core Fund Fund S000039982 · Registered fund · May 29, 2026 BlackRock Funds, not summed	198,634	0.33%	+56,108	May 29, 2026	BlackRock Funds, not summed
2	FARALLON CAPITAL MANAGEMENT LLC 13F CIK 909661 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	5,917,400	9.91%	+233,400	Jun 30, 2026	carried, not yet filed for the newest quarter
2.1	FARALLON CAPITAL MANAGEMENT LLC 13G CIK 909661 · Registered investment adviser · Jun 30, 2026 Rule 13d-1(b), qualified institution, not summed	5,917,400	9.91%	—	Jun 30, 2026	Rule 13d-1(b), qualified institution, not summed
3	Dapice Joshua J. 13G CIK 1175707 · Unknown · Dec 31, 2025 Rule 13d-1(c), passive investor	5,159,505	8.64%	-514,961	Dec 31, 2025	Rule 13d-1(c), passive investor
4	STATE STREET CORP 13F CIK 93751 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	3,533,633	5.92%	+168,754	Jun 30, 2026	carried, not yet filed for the newest quarter
4.1	State Street(R) SPDR(R) S&P(R) Biotech ETF Fund S000010018 · Registered fund · Jun 30, 2026 SPDR SERIES TRUST, not summed	2,005,301	3.36%	+74,977	Jun 30, 2026	SPDR SERIES TRUST, not summed
4.2	STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO Fund S000050332 · Registered fund · Jun 30, 2026 STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed	19,804	0.03%	-1,000	Jun 30, 2026	STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
4.3	State Street Institutional Small-Cap Equity Fund Fund S000001631 · Registered fund · Jun 30, 2026 STATE STREET INSTITUTIONAL FUNDS, not summed	12,195	0.02%	+6,666	Jun 30, 2026	STATE STREET INSTITUTIONAL FUNDS, not summed
4.4	State Street(R) SPDR(R) US Small Cap Low Volatility Index ETF Fund S000039795 · Registered fund · Jun 30, 2026 SPDR SERIES TRUST, not summed	6,650	0.01%	-620	Jun 30, 2026	SPDR SERIES TRUST, not summed
4.5	State Street Total Return V.I.S. Fund Fund S000001637 · Registered fund · Jun 30, 2026 STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed	1,493	0.00%	+159	Jun 30, 2026	STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
5	Lynx1 Capital Management LP 13F CIK 1910456 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	3,408,937	5.71%	+797,369	Jun 30, 2026	carried, not yet filed for the newest quarter
6	D. E. Shaw & Co., Inc. 13F CIK 1009207 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	3,107,005	5.20%	+425,836	Jun 30, 2026	carried, not yet filed for the newest quarter
7	VANGUARD PORTFOLIO MANAGEMENT LLC 13F CIK 2100121 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,898,197	4.85%	+287,162	Jun 30, 2026	carried, not yet filed for the newest quarter
8	Paradigm Biocapital Advisors LP 13G CIK 1855655 · Registered investment adviser · Sep 30, 2025 Rule 13d-1(c), passive investor	2,873,555	4.81%	-154,422	Sep 30, 2025	Rule 13d-1(c), passive investor
9	VANGUARD CAPITAL MANAGEMENT LLC 13F CIK 2100119 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,681,845	4.49%	+49,529	Jun 30, 2026	carried, not yet filed for the newest quarter
10	ARMISTICE CAPITAL, LLC 13F CIK 1601086 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,400,000	4.02%	-316,000	Jun 30, 2026	carried, not yet filed for the newest quarter
11	Erste Asset Management GmbH 13F CIK 2024532 · Non-US institution · Jun 30, 2026 carried, not yet filed for the newest quarter	2,154,900	3.61%	-550,000	Jun 30, 2026	carried, not yet filed for the newest quarter
12	NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 13F CIK 921739 · Investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	2,110,809	3.54%	+616,374	Jun 30, 2026	carried, not yet filed for the newest quarter
12.1	Nomura Small Cap Core Fund Fund S000002400 · Registered fund · May 29, 2026 Delaware Group Equity Funds V, not summed	1,144,753	1.92%	-75,150	May 29, 2026	Delaware Group Equity Funds V, not summed
13	VANGUARD TOTAL STOCK MARKET INDEX FUND Fund S000002848 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	1,889,447	3.16%	+14,535	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
14	Assenagon Asset Management S.A. 13F CIK 1546007 · Unknown · Sep 30, 2026	1,886,412	3.16%	+1,782,457	Sep 30, 2026
15	GEODE CAPITAL MANAGEMENT, LLC 13F CIK 1214717 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,574,268	2.64%	+106,358	Jun 30, 2026	carried, not yet filed for the newest quarter
16	SUSQUEHANNA INTERNATIONAL GROUP, LLP 13F CIK 1446194 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	1,375,558	2.30%	+30,605	Jun 30, 2026	carried, not yet filed for the newest quarter
17	VANGUARD SMALL-CAP INDEX FUND Fund S000002845 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	1,362,732	2.28%	+12,172	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
18	ADAR1 Capital Management, LLC 13F CIK 1940272 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,288,053	2.16%	+1,147,381	Jun 30, 2026	carried, not yet filed for the newest quarter
19	BNP PARIBAS ASSET MANAGEMENT Holding S.A. 13F CIK 1520354 · Non-US institution · Jun 30, 2026 carried, not yet filed for the newest quarter	1,280,044	2.14%	-300,796	Jun 30, 2026	carried, not yet filed for the newest quarter
20	DIMENSIONAL FUND ADVISORS LP 13F CIK 354204 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,248,738	2.09%	+97,124	Jun 30, 2026	carried, not yet filed for the newest quarter
20.1	U.S. SMALL CAP PORTFOLIO Fund S000000971 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	257,894	0.43%	+6,000	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
20.2	U.S. MICRO CAP PORTFOLIO Fund S000000948 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	245,365	0.41%	+1,376	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
20.3	Dimensional U.S. Small Cap ETF Fund S000070906 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	192,387	0.32%	-919	Jul 31, 2026	Dimensional ETF Trust, not summed
20.4	Dimensional U.S. Core Equity 2 ETF Fund S000070903 · Registered fund · Jul 31, 2026 Dimensional ETF Trust, not summed	148,210	0.25%	+11,640	Jul 31, 2026	Dimensional ETF Trust, not summed
20.5	U.S. CORE EQUITY 2 PORTFOLIO Fund S000000980 · Registered fund · Jul 31, 2026 DFA INVESTMENT DIMENSIONS GROUP INC, not summed	81,402	0.14%	-6,000	Jul 31, 2026	DFA INVESTMENT DIMENSIONS GROUP INC, not summed
21	GW&K Investment Management, LLC 13F CIK 1082917 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	1,206,615	2.02%	-8,286	Jun 30, 2026	carried, not yet filed for the newest quarter
22	GOLDMAN SACHS GROUP INC 13F CIK 886982 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	1,150,932	1.93%	+345,156	Jun 30, 2026	carried, not yet filed for the newest quarter
22.1	Goldman Sachs Small Cap Value Insights Fund Fund S000014929 · Registered fund · Jul 31, 2026 Goldman Sachs Trust, not summed	22,058	0.04%	—	Jul 31, 2026	Goldman Sachs Trust, not summed
22.2	Goldman Sachs Multi-Manager Global Equity Fund Fund S000049146 · Registered fund · Jul 31, 2026 Goldman Sachs Trust II, not summed	16,819	0.03%	-1,716	Jul 31, 2026	Goldman Sachs Trust II, not summed
22.3	Goldman Sachs ActiveBeta(R) U.S. Small Cap Equity ETF Fund S000048296 · Registered fund · May 31, 2026 Goldman Sachs ETF Trust, not summed	5,903	0.01%	+1,010	May 31, 2026	Goldman Sachs ETF Trust, not summed
23	UBS Group AG 13F CIK 1610520 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	985,831	1.65%	+853,291	Jun 30, 2026	carried, not yet filed for the newest quarter
24	MORGAN STANLEY 13F CIK 895421 · Holding company · Jun 30, 2026 carried, not yet filed for the newest quarter	963,256	1.61%	-4,269	Jun 30, 2026	carried, not yet filed for the newest quarter
24.1	E*TRADE No Fee Total Market Index Fund Fund S000090722 · Registered fund · Jul 31, 2026 E Trade Trust, not summed	55	0.00%	0	Jul 31, 2026	E Trade Trust, not summed
25	Nuveen, LLC 13F CIK 1871926 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	873,560	1.46%	+151,212	Jun 30, 2026	carried, not yet filed for the newest quarter
25.1	College Retirement Equities Fund - Total Global Stock Account Fund S000005080 · Registered fund · Jun 30, 2026 College Retirement Equities Fund, not summed	332,643	0.56%	+124,265	Jun 30, 2026	College Retirement Equities Fund, not summed
25.2	Nuveen Quant Small Cap Equity Fund Fund S000005386 · Registered fund · Jul 31, 2026 TIAA-CREF Funds, not summed	308,070	0.52%	-6,100	Jul 31, 2026	TIAA-CREF Funds, not summed
25.3	Nuveen Quant Small/Mid Cap Equity Fund Fund S000054623 · Registered fund · Jul 31, 2026 TIAA-CREF Funds, not summed	110,400	0.18%	+45,300	Jul 31, 2026	TIAA-CREF Funds, not summed
25.4	Nuveen Small Cap Blend Index Fund Fund S000005367 · Registered fund · Jul 31, 2026 TIAA-CREF Funds, not summed	78,384	0.13%	+10,352	Jul 31, 2026	TIAA-CREF Funds, not summed
25.5	Nuveen Equity Index Fund Fund S000005360 · Registered fund · Jul 31, 2026 TIAA-CREF Funds, not summed	42,864	0.07%	0	Jul 31, 2026	TIAA-CREF Funds, not summed
26	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 13F CIK 1164508 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	810,530	1.36%	+560,069	Jun 30, 2026	carried, not yet filed for the newest quarter
27	VANGUARD SMALL-CAP GROWTH INDEX FUND Fund S000002846 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	788,655	1.32%	+33,170	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
28	Foresite Capital Management VI LLC 13F CIK 2013341 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	785,000	1.31%	+260,000	Jun 30, 2026	carried, not yet filed for the newest quarter
29	CITADEL ADVISORS LLC 13F CIK 1423053 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	732,687	1.23%	+113,074	Jun 30, 2026	carried, not yet filed for the newest quarter
30	AQR CAPITAL MANAGEMENT LLC 13F CIK 1167557 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	684,340	1.15%	+647,930	Jun 30, 2026	carried, not yet filed for the newest quarter
30.1	AQR Small Cap Multi-Style Fund Fund S000040064 · Registered fund · Jun 30, 2026 AQR Funds, not summed	7,582	0.01%	—	Jun 30, 2026	AQR Funds, not summed
31	VANGUARD EXTENDED MARKET INDEX FUND Fund S000002841 · Registered fund · Jun 30, 2026 VANGUARD INDEX FUNDS, not summed	683,990	1.15%	+29,492	Jun 30, 2026	VANGUARD INDEX FUNDS, not summed
32	Parkman Healthcare Partners LLC 13F CIK 1777015 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	669,046	1.12%	+265,521	Jun 30, 2026	carried, not yet filed for the newest quarter
33	SCS Capital Management LLC 13F CIK 1303159 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	612,850	1.03%	0	Jun 30, 2026	carried, not yet filed for the newest quarter
34	Qube Research & Technologies Ltd 13F CIK 1729829 · Exempt reporting adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	597,638	1.00%	+409,971	Jun 30, 2026	carried, not yet filed for the newest quarter
35	NORTHERN TRUST CORP 13F CIK 73124 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	554,709	0.93%	+45,437	Jun 30, 2026	carried, not yet filed for the newest quarter
35.1	Small Cap Index Fund Fund S000001245 · Registered fund · Jun 30, 2026 Northern Funds, not summed	29,901	0.05%	+4,155	Jun 30, 2026	Northern Funds, not summed
35.2	FlexShares Morningstar US Market Factor Tilt Index Fund Fund S000033312 · Registered fund · Jul 31, 2026 FlexShares Trust, not summed	4,553	0.01%	+224	Jul 31, 2026	FlexShares Trust, not summed
35.3	Small Cap Core Fund Fund S000001244 · Registered fund · Jun 30, 2026 Northern Funds, not summed	3,155	0.01%	-152	Jun 30, 2026	Northern Funds, not summed
36	Defilade Capital Management, L.P. 13F CIK 2088557 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	546,848	0.92%	+546,848	Jun 30, 2026	carried, not yet filed for the newest quarter
37	CHARLES SCHWAB INVESTMENT MANAGEMENT INC 13F CIK 884546 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	538,128	0.90%	+61,096	Jun 30, 2026	carried, not yet filed for the newest quarter
37.1	Schwab U.S. Small-Cap ETF Fund S000026636 · Registered fund · May 31, 2026 SCHWAB STRATEGIC TRUST, not summed	280,734	0.47%	-1,314	May 31, 2026	SCHWAB STRATEGIC TRUST, not summed
37.2	Schwab Small-Cap Index Fund Fund S000005912 · Registered fund · Jul 31, 2026 SCHWAB CAPITAL TRUST, not summed	143,708	0.24%	+20,689	Jul 31, 2026	SCHWAB CAPITAL TRUST, not summed
37.3	Schwab Total Stock Market Index Fund Fund S000005913 · Registered fund · Jul 31, 2026 SCHWAB CAPITAL TRUST, not summed	36,506	0.06%	0	Jul 31, 2026	SCHWAB CAPITAL TRUST, not summed
37.4	Schwab U.S. Broad Market ETF Fund S000026631 · Registered fund · May 31, 2026 SCHWAB STRATEGIC TRUST, not summed	34,617	0.06%	+479	May 31, 2026	SCHWAB STRATEGIC TRUST, not summed
37.5	Schwab Small-Cap Equity Fund Fund S000005516 · Registered fund · Jul 31, 2026 SCHWAB CAPITAL TRUST, not summed	17,298	0.03%	—	Jul 31, 2026	SCHWAB CAPITAL TRUST, not summed
38	TWO SIGMA INVESTMENTS, LP 13F CIK 1179392 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	536,380	0.90%	+284,744	Jun 30, 2026	carried, not yet filed for the newest quarter
39	Rock Springs Capital Management LP 13F CIK 1595725 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	532,563	0.89%	-266,600	Jun 30, 2026	carried, not yet filed for the newest quarter
40	Schonfeld Strategic Advisors LLC 13F CIK 1665241 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	520,083	0.87%	+320,022	Jun 30, 2026	carried, not yet filed for the newest quarter
41	BANK OF AMERICA CORP /DE/ 13F CIK 70858 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	507,869	0.85%	-31	Jun 30, 2026	carried, not yet filed for the newest quarter
42	Point72 Asset Management, L.P. 13F CIK 1603466 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	506,344	0.85%	+506,344	Jun 30, 2026	carried, not yet filed for the newest quarter
43	JANE STREET GROUP, LLC 13F CIK 1595888 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	492,598	0.83%	-192,642	Jun 30, 2026	carried, not yet filed for the newest quarter
44	Legal & General Group Plc 13F CIK 764068 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	434,719	0.73%	+10,804	Jun 30, 2026	carried, not yet filed for the newest quarter
45	VANGUARD FIDUCIARY TRUST CO 13F CIK 933478 · Unknown · Jun 30, 2026 carried, not yet filed for the newest quarter	395,868	0.66%	+13,847	Jun 30, 2026	carried, not yet filed for the newest quarter
46	PANAGORA ASSET MANAGEMENT INC 13F CIK 883677 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	373,931	0.63%	+135,463	Jun 30, 2026	carried, not yet filed for the newest quarter
47	KENNEDY CAPITAL MANAGEMENT LLC 13F CIK 884589 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	373,230	0.63%	+97,774	Jun 30, 2026	carried, not yet filed for the newest quarter
47.1	Kennedy Capital ESG SMID Cap Fund Fund S000063803 · Registered fund · Jun 30, 2026 INVESTMENT MANAGERS SERIES TRUST II, not summed	17,503	0.03%	0	Jun 30, 2026	INVESTMENT MANAGERS SERIES TRUST II, not summed
47.2	Kennedy Capital Small Cap Value Fund Fund S000076118 · Registered fund · Jun 30, 2026 INVESTMENT MANAGERS SERIES TRUST II, not summed	15,150	0.03%	+5,180	Jun 30, 2026	INVESTMENT MANAGERS SERIES TRUST II, not summed
48	JPMORGAN CHASE & CO 13F CIK 19617 · Bank · Jun 30, 2026 carried, not yet filed for the newest quarter	359,756	0.60%	+208,198	Jun 30, 2026	carried, not yet filed for the newest quarter
49	Connor, Clark & Lunn Investment Management Ltd. 13F CIK 1596800 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	359,550	0.60%	-90,543	Jun 30, 2026	carried, not yet filed for the newest quarter
50	Squarepoint Ops LLC 13F CIK 1642575 · Registered investment adviser · Jun 30, 2026 carried, not yet filed for the newest quarter	321,138	0.54%	+112,250	Jun 30, 2026	carried, not yet filed for the newest quarter

26 more nested rows are not shown here; Every filing lists them all.

Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.

Showing 1–50 of 366 holders

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Key facts CIK 1439222 CUSIP 00847X104 13F (30d) 20 filings 20 filers Visit website Investor relations