Paradigm Biocapital Advisors LP

CIK

1855655

Location

NEW YORK, NY

Portfolio Value

Mid $4,894,261,596

Diversification

Diversified

Filing Date

Global Rank

#676 / 8,603 ▲ 173 · as of Mar 2026

Top Industry

Biotechnology 100.0%

3Y Alpha vs SPY

+4.5%

Period ended 3 months ago

Filed May 15, 2026 · 55d

18 quarters · since Dec 2021

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+97.9%

SPY

+76.0%

Annualised alpha

+4.8%

Max drawdown

−47.9%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

35 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

13.5%

−1.3 pts

Top 5

48.3%

−3.8 pts

Top 10

67.6%

−8.7 pts

HHI

671

Diversified−112

Portfolio Trend

18 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	100.0%	$4,894,261,596	35

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

13 positions

Ticker	Company	Δ Shares	Shares	Value
VRDN	Viridian Therapeutics, Inc.\DE	+1,705,791	3,148,893	$61,592,347
LXEO	Lexeo Therapeutics, Inc.	+1,420,936	6,184,134	$35,496,929
TERN	Terns Pharmaceuticals, Inc.	+1,406,213	2,216,499	$116,853,827
GMAB	Genmab A/S	+928,002	7,967,836	$213,777,039
EWTX	Edgewise Therapeutics, Inc.	+823,828	7,365,038	$231,998,697
PCVX	Vaxcyte, Inc.	+725,000	4,793,020	$278,522,392
ORKA	Oruka Therapeutics, Inc.	+610,000	2,320,316	$113,811,499
SYRE	Spyre Therapeutics, Inc.	+490,000	1,957,266	$98,724,497
OLMA	Olema Pharmaceuticals, Inc.	+476,404	8,020,576	$119,586,788
APGE	Apogee Therapeutics, Inc.	+225,000	1,348,243	$113,481,613
NUVL	Nuvalent, Inc.	+55,000	5,324,433	$545,488,160
ACLX	Arcellx, Inc.	+50,000	5,774,016	$662,972,517
RVMD	Revolution Medicines, Inc.	+11,300	6,655,703	$647,267,116
No positions match the current search.

Trimmed

Positions the filer reduced

7 positions

Ticker	Company	Δ Shares	Shares	Value
ERAS	Erasca, Inc.	−3,766,393	10,392,702	$168,153,918
URGN	UroGen Pharma Ltd.	−2,769,699	1,703,949	$30,637,003
SRRK	Scholar Rock Holding Corp	−1,836,077	1,226,080	$60,274,092
BBOT	BridgeBio Oncology Therapeutics, Inc.	−1,393,536	868,213	$7,770,506
ORIC	Oric Pharmaceuticals, Inc.	−700,000	1,701,217	$21,554,419
ABVX	Abivax S.A.	−645,000	772,473	$86,014,868
EYPT	EyePoint, Inc.	−549,038	3,142,437	$40,506,012
No positions match the current search.

New Positions

Positions the filer opened this quarter

10 positions

Ticker	Company	Shares	Value
INSM	INSMED Inc	1,254,488	$205,133,877
BLTE	Belite Bio, Inc	1,114,784	$177,741,160
CNTA	Centessa Pharmaceuticals plc	3,574,048	$141,961,186
CYTK	Cytokinetics Inc	1,480,857	$97,603,284
TNGX	Tango Therapeutics, Inc.	4,009,679	$83,882,484
MAZE	Maze Therapeutics, Inc.	2,744,399	$81,920,310
TYRA	Tyra Biosciences, Inc.	2,054,991	$78,706,155
MIRM	Mirum Pharmaceuticals, Inc.	625,000	$57,737,500
MANE	Veradermics, Inc	525,000	$33,153,750
GPCR	Structure Therapeutics Inc.	545,287	$26,282,833
No positions match the current search.

Sold Out

Positions the filer fully exited

3 positions

Ticker	Company	Shares	Value
CRNX	Crinetics Pharmaceuticals, Inc.	2,210,774	$102,911,529
BBIO	BridgeBio Pharma, Inc.	684,277	$52,340,347
OCUL	Ocular Therapeutix, Inc	2,935,284	$35,634,347
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

35 positions · $4,894,261,596 total · as of Mar 31, 2026

All sectors Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
ACLX	Arcellx, Inc. Healthcare	Added	5,774,016	+50,000	$662,972,517	+77.6%	13.55%
RVMD	Revolution Medicines, Inc. Healthcare	Added	6,655,703	+11,300	$647,267,116	+22.3%	13.23%
NUVL	Nuvalent, Inc. Healthcare	Added	5,324,433	+55,000	$545,488,160	+2.9%	11.15%
PCVX	Vaxcyte, Inc. Healthcare	Added	4,793,020	+725,000	$278,522,392	+48.4%	5.69%
EWTX	Edgewise Therapeutics, Inc. Healthcare	Reduced	7,365,038	-5,717,382	$231,998,697	−28.5%	4.74%
GMAB	Genmab A/S Healthcare	Added	7,967,836	+928,002	$213,777,039	−1.4%	4.37%
INSM	INSMED Inc Healthcare	NEW	1,254,488	NEW	$205,133,877	NEW	4.19%
TARS	Tarsus Pharmaceuticals, Inc. Healthcare	Held	2,562,154	0	$179,735,103	−14.3%	3.67%
BLTE	Belite Bio, Inc Healthcare	NEW	1,114,784	NEW	$177,741,160	NEW	3.63%
ERAS	Erasca, Inc. Healthcare	Reduced	10,392,702	-3,766,393	$168,153,918	+219.2%	3.44%
CNTA	Centessa Pharmaceuticals plc Healthcare	NEW	3,574,048	NEW	$141,961,186	NEW	2.90%
OLMA	Olema Pharmaceuticals, Inc. Healthcare	Added	8,020,576	+476,404	$119,586,788	−36.6%	2.44%
TERN	Terns Pharmaceuticals, Inc. Healthcare	Added	2,216,499	+1,406,213	$116,853,827	+257.0%	2.39%
ORKA	Oruka Therapeutics, Inc. Healthcare	Added	2,320,316	+610,000	$113,811,499	+119.5%	2.33%
APGE	Apogee Therapeutics, Inc. Healthcare	Added	1,348,243	+225,000	$113,481,613	+33.9%	2.32%
SYRE	Spyre Therapeutics, Inc. Healthcare	Added	1,957,266	+490,000	$98,724,497	+105.4%	2.02%
CYTK	Cytokinetics Inc Healthcare	NEW	1,480,857	NEW	$97,603,284	NEW	1.99%
ABVX	Abivax S.A. Healthcare	Reduced	772,473	-645,000	$86,014,868	−55.0%	1.76%
TNGX	Tango Therapeutics, Inc. Healthcare	NEW	4,009,679	NEW	$83,882,484	NEW	1.71%
MAZE	Maze Therapeutics, Inc. Healthcare	NEW	2,744,399	NEW	$81,920,310	NEW	1.67%
TYRA	Tyra Biosciences, Inc. Healthcare	NEW	2,054,991	NEW	$78,706,155	NEW	1.61%
VRDN	Viridian Therapeutics, Inc.\DE Healthcare	Added	3,148,893	+1,705,791	$61,592,347	+37.1%	1.26%
SRRK	Scholar Rock Holding Corp Healthcare	Reduced	1,226,080	-1,836,077	$60,274,092	−55.3%	1.23%
MIRM	Mirum Pharmaceuticals, Inc. Healthcare	NEW	625,000	NEW	$57,737,500	NEW	1.18%
EYPT	EyePoint, Inc. Healthcare	Reduced	3,142,437	-549,038	$40,506,012	−39.9%	0.83%
LXEO	Lexeo Therapeutics, Inc. Healthcare	Added	6,184,134	+1,420,936	$35,496,929	−25.0%	0.73%
MANE	Veradermics, Inc Healthcare	NEW	525,000	NEW	$33,153,750	NEW	0.68%
VOR	Vor Biopharma Inc. Healthcare	Held	1,750,000	0	$31,220,000	+36.4%	0.64%
URGN	UroGen Pharma Ltd. Healthcare	Reduced	1,703,949	-2,769,699	$30,637,003	−70.8%	0.63%
GPCR	Structure Therapeutics Inc. Healthcare	NEW	545,287	NEW	$26,282,833	NEW	0.54%
IVA	Inventiva S.A. Healthcare	Held	4,000,000	0	$22,200,000	+19.4%	0.45%
ORIC	Oric Pharmaceuticals, Inc. Healthcare	Reduced	1,701,217	-700,000	$21,554,419	+9.7%	0.44%
ASMB	Assembly Biosciences, Inc. Healthcare	Held	665,251	0	$18,460,715	−18.4%	0.38%
BBOT	BridgeBio Oncology Therapeutics, Inc. Healthcare	Reduced	868,213	-1,393,536	$7,770,506	−72.6%	0.16%
KLRS	Kalaris Therapeutics, Inc. Healthcare	Held	700,000	0	$4,039,000	−31.6%	0.08%