SYRE · Spyre Therapeutics, Inc. · Shareholders & Ownership
Substantial doubt about the company's ability to continue as a going concern.
“We will need to raise additional capital to continue to fund our operations in the future. If we are unable to raise additional capital when needed, we will not be able to continue as a going concern.”View the 10-Q filed Aug 4, 2026
Every disclosed holder of SYRE in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.
Who Owns SYRE
13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positionsNo chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.
| Holder group | Shares | % Out |
|---|---|---|
| Institutional (13F) | 96,422,754 | 109.36% |
| Insiders (Forms 3, 4, 5) | 1,104,151 | 1.25% |
| 13D/G-only blocks | 9,435,588 | 10.70% |
| Remaining | 18,788,731 | -21.31% |
| Registered funds (N-PORT, not summed) | 33,992,780 | 38.55% |
Shares outstanding: 88,173,762, the issuer's latest cover-page count restated onto today's split basis.
Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.
13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.
Holders of SYRE
| # | Holder | Shares | As of | Notes |
|---|---|---|---|---|
| 1 |
FMR LLC
13F
CIK 315066 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
13,026,187 | ||
| 1.1 |
Fidelity Growth Company Fund
Fund
S000007119 · Registered fund · May 31, 2026
Fidelity Mt. Vernon Street Trust, not summed
|
2,576,969 | ||
| 1.2 |
Fidelity Advisor Biotechnology Fund
Fund
S000005321 · Registered fund · Jul 31, 2026
Fidelity Advisor Series VII, not summed
|
857,347 | ||
| 1.3 |
Fidelity Small Cap Index Fund
Fund
S000033638 · Registered fund · Jul 31, 2026
Fidelity Salem Street Trust, not summed
|
814,290 | ||
| 1.4 |
Fidelity Small Cap Growth Fund
Fund
S000007193 · Registered fund · Jul 31, 2026
Fidelity Securities Fund, not summed
|
777,720 | ||
| 1.5 |
Select Health Care Portfolio
Fund
S000007466 · Registered fund · May 31, 2026
Fidelity Select Portfolios, not summed
|
760,000 | ||
| 2 |
Fairmount Funds Management LLC
13D
CIK 1802528 · Registered investment adviser · Oct 7, 2026
Item 4 purpose: not restated by this amendment, the earlier 13D's purpose stands
not summed
|
9,354,200 | ||
| 2.1 |
|
406,038 | ||
| 3 |
BlackRock, Inc.
13F
CIK 2012383 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
6,506,605 | ||
| 3.1 |
iShares Russell 2000 ETF
Fund
S000004344 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
1,911,678 | ||
| 3.2 |
iShares Russell 2000 Growth ETF
Fund
S000004343 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
687,511 | ||
| 3.3 |
iShares Biotechnology ETF
Fund
S000004350 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
547,684 | ||
| 3.4 |
Master Small Cap Index Series
Fund
S000002716 · Registered fund · Jun 30, 2026
Quantitative Master Series LLC, not summed
|
137,310 | ||
| 3.5 |
iShares Core S&P Total U.S. Stock Market ETF
Fund
S000004317 · Registered fund · Jun 30, 2026
iShares Trust, not summed
|
102,323 | ||
| 4 |
Paradigm Biocapital Advisors LP
13G
CIK 1855655 · Registered investment adviser · Sep 24, 2026
Rule 13d-1(c), passive investor, not summed
|
4,457,450 | ||
| 4.1 |
Paradigm Biocapital Advisors LP
13F
CIK 1855655 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
3,840,778 | ||
| 5 |
PERCEPTIVE ADVISORS LLC
13F
CIK 1224962 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
4,319,496 | ||
| 5.1 |
PERCEPTIVE ADVISORS LLC
13G
CIK 1224962 · Registered investment adviser · Jun 30, 2026
Rule 13d-1(c), passive investor, not summed
|
4,319,496 | ||
| 6 |
RTW INVESTMENTS, LP
13F
CIK 1493215 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
4,251,996 | ||
| 6.1 |
RTW INVESTMENTS, LP
13G
CIK 1493215 · Registered investment adviser · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
|
4,251,996 | ||
| 7 |
VANGUARD CAPITAL MANAGEMENT LLC
13F
CIK 2100119 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
3,448,681 | ||
| 8 |
VANGUARD GROUP INC
13G
CIK 102909 · Registered investment adviser · Jun 30, 2025
Rule 13d-1(b), qualified institution
|
3,066,586 | ||
| 9 |
|
3,057,416 | ||
| 9.1 |
State Street(R) SPDR(R) S&P(R) Biotech ETF
Fund
S000010018 · Registered fund · Jun 30, 2026
SPDR SERIES TRUST, not summed
|
1,326,035 | ||
| 9.2 |
STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO
Fund
S000050332 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
|
26,800 | ||
| 9.3 |
State Street Total Return V.I.S. Fund
Fund
S000001637 · Registered fund · Jun 30, 2026
STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
|
1,834 | ||
| 9.4 |
State Street Balanced Index Fund
Fund
S000082802 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
|
429 | ||
| 9.5 |
State Street(R) SPDR(R) Portfolio MSCI Global Stock Market ETF
Fund
S000036082 · Registered fund · Jun 30, 2026
SPDR INDEX SHARES FUNDS, not summed
|
356 | ||
| 10 |
Venrock Adviser, LLC
13F
CIK 1615982 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
2,985,448 | ||
| 11 |
PRICE T ROWE ASSOCIATES INC /MD/
13F
CIK 80255 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
2,960,855 | ||
| 11.1 |
T. Rowe Price Health Sciences Fund, Inc.
Fund
S000002088 · Registered fund · Jun 30, 2026
T. ROWE PRICE HEALTH SCIENCES FUND, INC., not summed
|
711,845 | ||
| 11.2 |
T. Rowe Price New Horizons Fund, Inc.
Fund
S000002106 · Registered fund · Jun 30, 2026
T. ROWE PRICE NEW HORIZONS FUND, INC., not summed
|
673,799 | ||
| 11.3 |
T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund
Fund
S000002074 · Registered fund · Jun 30, 2026
T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC., not summed
|
509,247 | ||
| 11.4 |
T. Rowe Price Health Sciences Portfolio
Fund
S000002083 · Registered fund · Jun 30, 2026
T. ROWE PRICE EQUITY SERIES, INC., not summed
|
47,651 | ||
| 11.5 |
T. Rowe Price Small-Mid Cap ETF
Fund
S000079837 · Registered fund · Jun 30, 2026
T. Rowe Price Exchange-Traded Funds, Inc., not summed
|
27,295 | ||
| 12 |
Driehaus Capital Management LLC
13F
CIK 938206 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
2,799,166 | ||
| 12.1 |
Driehaus Small Cap Growth Fund
Fund
S000058261 · Registered fund · Jun 30, 2026
Driehaus Mutual Funds, not summed
|
309,152 | ||
| 12.2 |
Driehaus Micro Cap Growth Fund
Fund
S000042829 · Registered fund · Jun 30, 2026
Driehaus Mutual Funds, not summed
|
134,180 | ||
| 13 |
SMALLCAP World Fund Inc
Fund
S000009599 · Registered fund · Jun 30, 2026
SMALLCAP World Fund Inc, not summed
|
2,780,536 | ||
| 14 |
Venrock Healthcare Capital Partners III, L.P.
13G
CIK 1738048 · Unknown · Dec 31, 2024
Rule 13d-1(c), passive investor
|
2,685,448 | ||
| 15 |
GEODE CAPITAL MANAGEMENT, LLC
13F
CIK 1214717 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
2,562,265 | ||
| 16 |
VANGUARD TOTAL STOCK MARKET INDEX FUND
Fund
S000002848 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
2,482,298 | ||
| 17 |
VANGUARD PORTFOLIO MANAGEMENT LLC
13F
CIK 2100121 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
2,330,098 | ||
| 18 |
Capital World Investors
13F
CIK 1422849 · Investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
2,315,553 | ||
| 19 |
Jupiter Topco LLC
13F
CIK 2146052 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
2,206,936 | ||
| 20 |
Avoro Capital Advisors LLC
13G
CIK 1633313 · Registered investment adviser · Dec 31, 2023
Rule 13d-1(b), qualified institution
|
2,125,597 | ||
| 21 |
TCG Crossover Management, LLC
13F
CIK 1839948 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,900,582 | ||
| 22 |
TANG CAPITAL MANAGEMENT LLC
13F
CIK 1232621 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,892,200 | ||
| 23 |
BANK OF AMERICA CORP /DE/
13F
CIK 70858 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,777,854 | ||
| 24 |
ADAGE CAPITAL PARTNERS GP, L.L.C.
13F
CIK 1165408 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,722,300 | ||
| 25 |
WELLINGTON MANAGEMENT GROUP LLP
13F
CIK 902219 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,581,505 | ||
| 26 |
GOLDMAN SACHS GROUP INC
13F
CIK 886982 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,478,059 | ||
| 26.1 |
Goldman Sachs Small Cap Value Fund
Fund
S000009323 · Registered fund · May 31, 2026
Goldman Sachs Trust, not summed
|
34,595 | ||
| 26.2 |
Goldman Sachs Small Cap Equity Insights Fund
Fund
S000009329 · Registered fund · Jul 31, 2026
Goldman Sachs Trust, not summed
|
26,707 | ||
| 26.3 |
Goldman Sachs Variable Insurance Trust Mid Cap Value Fund
Fund
S000009358 · Registered fund · Jun 30, 2026
Goldman Sachs Variable Insurance Trust, not summed
|
24,498 | ||
| 26.4 |
Goldman Sachs Small Cap Growth Fund
Fund
S000061413 · Registered fund · May 31, 2026
Goldman Sachs Trust, not summed
|
19,386 | ||
| 26.5 |
Goldman Sachs Small Cap Growth Insights Fund
Fund
S000014930 · Registered fund · Jul 31, 2026
Goldman Sachs Trust, not summed
|
18,649 | ||
| 27 |
FRANKLIN RESOURCES INC
13F
CIK 38777 · Investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,472,943 | ||
| 27.1 |
Putnam Small Cap Growth Fund
Fund
S000000777 · Registered fund · Jun 30, 2026
Putnam Funds Trust, not summed
|
263,526 | ||
| 27.2 |
Franklin Biotechnology Discovery Fund
Fund
S000006882 · Registered fund · Jul 31, 2026
Franklin Strategic Series, not summed
|
245,009 | ||
| 27.3 |
Franklin Small Cap Growth Fund
Fund
S000006889 · Registered fund · Jul 31, 2026
Franklin Strategic Series, not summed
|
195,293 | ||
| 27.4 |
Franklin Alternative Strategies Fund
Fund
S000042023 · Registered fund · May 29, 2026
Franklin Alternative Strategies Funds, not summed
|
7,854 | ||
| 27.5 |
Putnam VT Small Cap Growth Fund
Fund
S000003883 · Registered fund · Jun 30, 2026
Putnam Variable Trust, not summed
|
4,040 | ||
| 28 |
Remedium Capital Partners, LLC
13F
CIK 2104501 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,464,169 | ||
| 29 |
Affinity Asset Advisors, LLC
13F
CIK 1773195 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,279,134 | ||
| 30 |
JPMORGAN CHASE & CO
13F
CIK 19617 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,093,026 | ||
| 31 |
Holocene Advisors, LP
13F
CIK 1700574 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
1,015,170 | ||
| 32 |
MARSHALL WACE, LLP
13F
CIK 1318757 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
991,693 | ||
| 33 |
Polar Capital Holdings Plc
13F
CIK 1837309 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
988,009 | ||
| 34 |
Siren, L.L.C.
13F
CIK 2005245 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
968,598 | ||
| 35 |
Capital International Investors
13F
CIK 1562230 · Investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
955,196 | ||
| 36 |
VANGUARD SMALL-CAP INDEX FUND
Fund
S000002845 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
896,559 | ||
| 37 |
EcoR1 Capital, LLC
13G
CIK 1587114 · Registered investment adviser · Dec 31, 2023
Rule 13d-1(b), qualified institution
|
887,076 | ||
| 38 |
VANGUARD EXTENDED MARKET INDEX FUND
Fund
S000002841 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
886,177 | ||
| 39 |
BRAIDWELL LP
13F
CIK 1920938 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
879,467 | ||
| 40 |
Commodore Capital LP
13F
CIK 1831942 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
846,786 | ||
| 41 |
|
843,071 | ||
| 42 |
NORTHERN TRUST CORP
13F
CIK 73124 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
|
674,529 | ||
| 42.1 |
Small Cap Index Fund
Fund
S000001245 · Registered fund · Jun 30, 2026
Northern Funds, not summed
|
37,656 | ||
| 42.2 |
FlexShares Morningstar US Market Factor Tilt Index Fund
Fund
S000033312 · Registered fund · Jul 31, 2026
FlexShares Trust, not summed
|
4,212 | ||
| 42.3 |
Small Cap Core Fund
Fund
S000001244 · Registered fund · Jun 30, 2026
Northern Funds, not summed
|
2,806 | ||
| 43 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
13F
CIK 884546 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
652,958 | ||
| 43.1 |
Schwab U.S. Small-Cap ETF
Fund
S000026636 · Registered fund · May 31, 2026
SCHWAB STRATEGIC TRUST, not summed
|
360,437 | ||
| 43.2 |
Schwab Small-Cap Index Fund
Fund
S000005912 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
|
180,878 | ||
| 43.3 |
Schwab Total Stock Market Index Fund
Fund
S000005913 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
|
46,825 | ||
| 43.4 |
Schwab U.S. Broad Market ETF
Fund
S000026631 · Registered fund · May 31, 2026
SCHWAB STRATEGIC TRUST, not summed
|
44,082 | ||
| 43.5 |
Schwab Small-Cap Equity Fund
Fund
S000005516 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
|
13,994 | ||
| 44 |
Pictet Asset Management Holding SA
13F
CIK 1993888 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
628,138 | ||
| 45 |
Assenagon Asset Management S.A.
13F
CIK 1546007 · Unknown · Sep 30, 2026
|
599,224 | ||
| 46 |
VANGUARD SMALL-CAP VALUE INDEX FUND
Fund
S000002847 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
|
567,724 | ||
| 47 |
EMERALD ADVISERS, LLC
13F
CIK 1015083 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
567,430 | ||
| 48 |
VICTORY CAPITAL MANAGEMENT INC
13F
CIK 1040188 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
553,980 | ||
| 48.1 |
Victory Pioneer Select Mid Cap Growth Fund
Fund
S000089755 · Registered fund · May 31, 2026
Victory Portfolios IV, not summed
|
249,308 | ||
| 48.2 |
Victory RS Small Cap Growth Fund
Fund
S000053581 · Registered fund · Jun 30, 2026
Victory Portfolios, not summed
|
85,798 | ||
| 48.3 |
Victory Science & Technology Fund
Fund
S000012911 · Registered fund · Jul 31, 2026
Victory Portfolios III, not summed
|
76,720 | ||
| 48.4 |
VictoryShares US Small Mid Cap Value Momentum ETF
Fund
S000065161 · Registered fund · Jun 30, 2026
Victory Portfolios II, not summed
|
40,598 | ||
| 48.5 |
Victory Small Cap Stock Fund
Fund
S000012914 · Registered fund · Jul 31, 2026
Victory Portfolios III, not summed
|
36,353 | ||
| 49 |
VANGUARD FIDUCIARY TRUST CO
13F
CIK 933478 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
|
551,389 | ||
| 50 |
Candriam S.C.A.
13F
CIK 1537014 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
|
546,312 |
66 more nested rows are not shown here; Every filing lists them all.
Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.
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