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SYRE · Spyre Therapeutics, Inc. · Shareholders & Ownership

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$92.09 +7.37 (+8.70%)
Market Cap
$7.47B
Shares
88.17M
Volume · Oct 20 319.33K Avg daily vol (3M) 1.2M

Every disclosed holder of SYRE in one list: 13F institutions, Schedule 13D and 13G filers, insiders (Forms 3, 4 and 5) and registered funds, each from its own latest filing. Holders nest by CIK and SEC reporting links, never by name, and each is summed once.

Who Owns SYRE

13F quarter Sep 30, 2026, combined view: filers that have not filed yet carry their Jun 30, 2026 positions

No chart: the summed disclosures exceed shares outstanding, so they are not parts of one whole.

Holder group Shares % Out
Institutional (13F) 96,422,754 109.36%
Insiders (Forms 3, 4, 5) 1,104,151 1.25%
13D/G-only blocks 9,435,588 10.70%
Remaining 18,788,731 -21.31%
Registered funds (N-PORT, not summed) 33,992,780 38.55%

Shares outstanding: 88,173,762, the issuer's latest cover-page count restated onto today's split basis.

Remaining is negative: the summed disclosures exceed shares outstanding, as when filings are dated at different times or holders that do not disclose their links count the same shares. It is flagged, not clipped.

13D/G-only counts each filer's latest 13D or 13G that no 13F report of the listing contains, that names no 13F filer and that no counted insider files. Funds are never summed: their shares sit inside their advisers' 13F reports.

Holders of SYRE

# Holder Shares
1
FMR LLC
13F CIK 315066 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
13,026,187
1.1
Fidelity Growth Company Fund
Fund S000007119 · Registered fund · May 31, 2026
Fidelity Mt. Vernon Street Trust, not summed
2,576,969
1.2
Fidelity Advisor Biotechnology Fund
Fund S000005321 · Registered fund · Jul 31, 2026
Fidelity Advisor Series VII, not summed
857,347
1.3
Fidelity Small Cap Index Fund
Fund S000033638 · Registered fund · Jul 31, 2026
Fidelity Salem Street Trust, not summed
814,290
1.4
Fidelity Small Cap Growth Fund
Fund S000007193 · Registered fund · Jul 31, 2026
Fidelity Securities Fund, not summed
777,720
1.5
Select Health Care Portfolio
Fund S000007466 · Registered fund · May 31, 2026
Fidelity Select Portfolios, not summed
760,000
2
Fairmount Funds Management LLC
13D CIK 1802528 · Registered investment adviser · Oct 7, 2026
Item 4 purpose: not restated by this amendment, the earlier 13D's purpose stands
not summed
9,354,200
2.1
Fairmount Funds Management LLC
Insider CIK 1802528 · Jun 23, 2026
Director, issuer-wide
406,038
3
BlackRock, Inc.
13F CIK 2012383 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
6,506,605
3.1
iShares Russell 2000 ETF
Fund S000004344 · Registered fund · Jun 30, 2026
iShares Trust, not summed
1,911,678
3.2
iShares Russell 2000 Growth ETF
Fund S000004343 · Registered fund · Jun 30, 2026
iShares Trust, not summed
687,511
3.3
iShares Biotechnology ETF
Fund S000004350 · Registered fund · Jun 30, 2026
iShares Trust, not summed
547,684
3.4
Master Small Cap Index Series
Fund S000002716 · Registered fund · Jun 30, 2026
Quantitative Master Series LLC, not summed
137,310
3.5
iShares Core S&P Total U.S. Stock Market ETF
Fund S000004317 · Registered fund · Jun 30, 2026
iShares Trust, not summed
102,323
4
Paradigm Biocapital Advisors LP
13G CIK 1855655 · Registered investment adviser · Sep 24, 2026
Rule 13d-1(c), passive investor, not summed
4,457,450
4.1
Paradigm Biocapital Advisors LP
13F CIK 1855655 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
3,840,778
5
PERCEPTIVE ADVISORS LLC
13F CIK 1224962 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
4,319,496
5.1
PERCEPTIVE ADVISORS LLC
13G CIK 1224962 · Registered investment adviser · Jun 30, 2026
Rule 13d-1(c), passive investor, not summed
4,319,496
6
RTW INVESTMENTS, LP
13F CIK 1493215 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
4,251,996
6.1
RTW INVESTMENTS, LP
13G CIK 1493215 · Registered investment adviser · Jun 30, 2026
Rule 13d-1(b), qualified institution, not summed
4,251,996
7
VANGUARD CAPITAL MANAGEMENT LLC
13F CIK 2100119 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
3,448,681
8
VANGUARD GROUP INC
13G CIK 102909 · Registered investment adviser · Jun 30, 2025
Rule 13d-1(b), qualified institution
3,066,586
9
STATE STREET CORP
13F CIK 93751 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
3,057,416
9.1
State Street(R) SPDR(R) S&P(R) Biotech ETF
Fund S000010018 · Registered fund · Jun 30, 2026
SPDR SERIES TRUST, not summed
1,326,035
9.2
STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO
Fund S000050332 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
26,800
9.3
State Street Total Return V.I.S. Fund
Fund S000001637 · Registered fund · Jun 30, 2026
STATE STREET VARIABLE INSURANCE SERIES FUNDS INC, not summed
1,834
9.4
State Street Balanced Index Fund
Fund S000082802 · Registered fund · Jun 30, 2026
STATE STREET INSTITUTIONAL INVESTMENT TRUST, not summed
429
9.5
State Street(R) SPDR(R) Portfolio MSCI Global Stock Market ETF
Fund S000036082 · Registered fund · Jun 30, 2026
SPDR INDEX SHARES FUNDS, not summed
356
10
Venrock Adviser, LLC
13F CIK 1615982 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
2,985,448
11
PRICE T ROWE ASSOCIATES INC /MD/
13F CIK 80255 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
2,960,855
11.1
T. Rowe Price Health Sciences Fund, Inc.
Fund S000002088 · Registered fund · Jun 30, 2026
T. ROWE PRICE HEALTH SCIENCES FUND, INC., not summed
711,845
11.2
T. Rowe Price New Horizons Fund, Inc.
Fund S000002106 · Registered fund · Jun 30, 2026
T. ROWE PRICE NEW HORIZONS FUND, INC., not summed
673,799
11.3
T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund
Fund S000002074 · Registered fund · Jun 30, 2026
T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC., not summed
509,247
11.4
T. Rowe Price Health Sciences Portfolio
Fund S000002083 · Registered fund · Jun 30, 2026
T. ROWE PRICE EQUITY SERIES, INC., not summed
47,651
11.5
T. Rowe Price Small-Mid Cap ETF
Fund S000079837 · Registered fund · Jun 30, 2026
T. Rowe Price Exchange-Traded Funds, Inc., not summed
27,295
12
Driehaus Capital Management LLC
13F CIK 938206 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
2,799,166
12.1
Driehaus Small Cap Growth Fund
Fund S000058261 · Registered fund · Jun 30, 2026
Driehaus Mutual Funds, not summed
309,152
12.2
Driehaus Micro Cap Growth Fund
Fund S000042829 · Registered fund · Jun 30, 2026
Driehaus Mutual Funds, not summed
134,180
13
SMALLCAP World Fund Inc
Fund S000009599 · Registered fund · Jun 30, 2026
SMALLCAP World Fund Inc, not summed
2,780,536
14
Venrock Healthcare Capital Partners III, L.P.
13G CIK 1738048 · Unknown · Dec 31, 2024
Rule 13d-1(c), passive investor
2,685,448
15
GEODE CAPITAL MANAGEMENT, LLC
13F CIK 1214717 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
2,562,265
16
VANGUARD TOTAL STOCK MARKET INDEX FUND
Fund S000002848 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
2,482,298
17
VANGUARD PORTFOLIO MANAGEMENT LLC
13F CIK 2100121 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
2,330,098
18
Capital World Investors
13F CIK 1422849 · Investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
2,315,553
19
Jupiter Topco LLC
13F CIK 2146052 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
2,206,936
20
Avoro Capital Advisors LLC
13G CIK 1633313 · Registered investment adviser · Dec 31, 2023
Rule 13d-1(b), qualified institution
2,125,597
21
TCG Crossover Management, LLC
13F CIK 1839948 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
1,900,582
22
TANG CAPITAL MANAGEMENT LLC
13F CIK 1232621 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
1,892,200
23
BANK OF AMERICA CORP /DE/
13F CIK 70858 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
1,777,854
24
ADAGE CAPITAL PARTNERS GP, L.L.C.
13F CIK 1165408 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
1,722,300
25
WELLINGTON MANAGEMENT GROUP LLP
13F CIK 902219 · Holding company · Jun 30, 2026
carried, not yet filed for the newest quarter
1,581,505
26
GOLDMAN SACHS GROUP INC
13F CIK 886982 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
1,478,059
26.1
Goldman Sachs Small Cap Value Fund
Fund S000009323 · Registered fund · May 31, 2026
Goldman Sachs Trust, not summed
34,595
26.2
Goldman Sachs Small Cap Equity Insights Fund
Fund S000009329 · Registered fund · Jul 31, 2026
Goldman Sachs Trust, not summed
26,707
26.3
Goldman Sachs Variable Insurance Trust Mid Cap Value Fund
Fund S000009358 · Registered fund · Jun 30, 2026
Goldman Sachs Variable Insurance Trust, not summed
24,498
26.4
Goldman Sachs Small Cap Growth Fund
Fund S000061413 · Registered fund · May 31, 2026
Goldman Sachs Trust, not summed
19,386
26.5
Goldman Sachs Small Cap Growth Insights Fund
Fund S000014930 · Registered fund · Jul 31, 2026
Goldman Sachs Trust, not summed
18,649
27
FRANKLIN RESOURCES INC
13F CIK 38777 · Investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
1,472,943
27.1
Putnam Small Cap Growth Fund
Fund S000000777 · Registered fund · Jun 30, 2026
Putnam Funds Trust, not summed
263,526
27.2
Franklin Biotechnology Discovery Fund
Fund S000006882 · Registered fund · Jul 31, 2026
Franklin Strategic Series, not summed
245,009
27.3
Franklin Small Cap Growth Fund
Fund S000006889 · Registered fund · Jul 31, 2026
Franklin Strategic Series, not summed
195,293
27.4
Franklin Alternative Strategies Fund
Fund S000042023 · Registered fund · May 29, 2026
Franklin Alternative Strategies Funds, not summed
7,854
27.5
Putnam VT Small Cap Growth Fund
Fund S000003883 · Registered fund · Jun 30, 2026
Putnam Variable Trust, not summed
4,040
28
Remedium Capital Partners, LLC
13F CIK 2104501 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
1,464,169
29
Affinity Asset Advisors, LLC
13F CIK 1773195 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
1,279,134
30
JPMORGAN CHASE & CO
13F CIK 19617 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
1,093,026
31
Holocene Advisors, LP
13F CIK 1700574 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
1,015,170
32
MARSHALL WACE, LLP
13F CIK 1318757 · Exempt reporting adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
991,693
33
Polar Capital Holdings Plc
13F CIK 1837309 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
988,009
34
Siren, L.L.C.
13F CIK 2005245 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
968,598
35
Capital International Investors
13F CIK 1562230 · Investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
955,196
36
VANGUARD SMALL-CAP INDEX FUND
Fund S000002845 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
896,559
37
EcoR1 Capital, LLC
13G CIK 1587114 · Registered investment adviser · Dec 31, 2023
Rule 13d-1(b), qualified institution
887,076
38
VANGUARD EXTENDED MARKET INDEX FUND
Fund S000002841 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
886,177
39
BRAIDWELL LP
13F CIK 1920938 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
879,467
40
Commodore Capital LP
13F CIK 1831942 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
846,786
41
UBS Group AG
13F CIK 1610520 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
843,071
42
NORTHERN TRUST CORP
13F CIK 73124 · Bank · Jun 30, 2026
carried, not yet filed for the newest quarter
674,529
42.1
Small Cap Index Fund
Fund S000001245 · Registered fund · Jun 30, 2026
Northern Funds, not summed
37,656
42.2
FlexShares Morningstar US Market Factor Tilt Index Fund
Fund S000033312 · Registered fund · Jul 31, 2026
FlexShares Trust, not summed
4,212
42.3
Small Cap Core Fund
Fund S000001244 · Registered fund · Jun 30, 2026
Northern Funds, not summed
2,806
43
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
13F CIK 884546 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
652,958
43.1
Schwab U.S. Small-Cap ETF
Fund S000026636 · Registered fund · May 31, 2026
SCHWAB STRATEGIC TRUST, not summed
360,437
43.2
Schwab Small-Cap Index Fund
Fund S000005912 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
180,878
43.3
Schwab Total Stock Market Index Fund
Fund S000005913 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
46,825
43.4
Schwab U.S. Broad Market ETF
Fund S000026631 · Registered fund · May 31, 2026
SCHWAB STRATEGIC TRUST, not summed
44,082
43.5
Schwab Small-Cap Equity Fund
Fund S000005516 · Registered fund · Jul 31, 2026
SCHWAB CAPITAL TRUST, not summed
13,994
44
Pictet Asset Management Holding SA
13F CIK 1993888 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
628,138
45
Assenagon Asset Management S.A.
13F CIK 1546007 · Unknown · Sep 30, 2026
599,224
46
VANGUARD SMALL-CAP VALUE INDEX FUND
Fund S000002847 · Registered fund · Jun 30, 2026
VANGUARD INDEX FUNDS, not summed
567,724
47
EMERALD ADVISERS, LLC
13F CIK 1015083 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
567,430
48
VICTORY CAPITAL MANAGEMENT INC
13F CIK 1040188 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
553,980
48.1
Victory Pioneer Select Mid Cap Growth Fund
Fund S000089755 · Registered fund · May 31, 2026
Victory Portfolios IV, not summed
249,308
48.2
Victory RS Small Cap Growth Fund
Fund S000053581 · Registered fund · Jun 30, 2026
Victory Portfolios, not summed
85,798
48.3
Victory Science & Technology Fund
Fund S000012911 · Registered fund · Jul 31, 2026
Victory Portfolios III, not summed
76,720
48.4
VictoryShares US Small Mid Cap Value Momentum ETF
Fund S000065161 · Registered fund · Jun 30, 2026
Victory Portfolios II, not summed
40,598
48.5
Victory Small Cap Stock Fund
Fund S000012914 · Registered fund · Jul 31, 2026
Victory Portfolios III, not summed
36,353
49
VANGUARD FIDUCIARY TRUST CO
13F CIK 933478 · Unknown · Jun 30, 2026
carried, not yet filed for the newest quarter
551,389
50
Candriam S.C.A.
13F CIK 1537014 · Registered investment adviser · Jun 30, 2026
carried, not yet filed for the newest quarter
546,312

66 more nested rows are not shown here; Every filing lists them all.

Shares are restated onto today's split basis. Change compares each row with the same holder's previous filing in the same source; a dash means there is none to compare. Nested 13D/G, insider and fund rows are not summed, since a 13F report already holds them.

Showing 1–50 of 413 holders

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Key facts CIK 1636282 CUSIP 00773J202 13F (30d) 12 filings 12 filers Visit website Investor relations