Commodore Capital LP

CIK

1831942

Location

NEW YORK, NY

Portfolio Value

Mid $1,728,452,363

Diversification

Diversified

Filing Date

Global Rank

#1,296 / 8,603 ▲ 148 · as of Mar 2026

Top Industry

Biotechnology 85.0%

3Y Alpha vs SPY

+15.1%

Period ended 3 months ago

Filed May 15, 2026 · 55d

22 quarters · since Dec 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+151.0%

SPY

+76.0%

Annualised alpha

+15.2%

Max drawdown

−53.5%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

36 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

9.8%

−0.0 pts

Top 5

37.8%

+4.4 pts

Top 10

61.3%

+4.2 pts

HHI

493

Diversified+23

Portfolio Trend

22 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	99.7%	$1,723,372,363	35
Financial Services	0.3%	$5,080,000	1

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

7 positions

Ticker	Company	Δ Shares	Shares	Value
PEPG	PepGen Inc.	+1,075,000	4,475,000	$7,920,750
ANRO	Alto Neuroscience, Inc.	+900,000	2,723,196	$61,217,446
COGT	Cogent Biosciences, Inc.	+691,162	2,888,007	$111,159,389
ALKS	Alkermes plc.	+650,000	4,200,000	$148,512,000
NUVL	Nuvalent, Inc.	+283,600	833,600	$85,402,320
CLDX	Celldex Therapeutics, Inc.	+131,616	2,696,616	$85,536,659
PHVS	Pharvaris N.V.	+29,525	1,918,970	$54,210,902
No positions match the current search.

Trimmed

Positions the filer reduced

6 positions

Ticker	Company	Δ Shares	Shares	Value
PALI	Palisade Bio, Inc.	−4,263,938	7,181,062	$12,566,858
ELVN	Enliven Therapeutics, Inc.	−1,417,809	3,275,000	$128,380,000
XENE	Xenon Pharmaceuticals Inc.	−975,000	825,000	$47,973,750
TYRA	Tyra Biosciences, Inc.	−900,000	2,475,000	$94,792,500
SLNO	Soleno Therapeutics Inc	−547,568	652,432	$21,843,423
SYRE	Spyre Therapeutics, Inc.	−475,865	1,912,380	$96,460,447
No positions match the current search.

New Positions

Positions the filer opened this quarter

13 positions

Ticker	Company	Shares	Value
ERAS	Erasca, Inc.	3,175,000	$51,371,500
DMRA	Damora Therapeutics, Inc.	1,939,000	$50,220,100
DFTX	Definium Therapeutics, Inc.	2,000,000	$37,800,000
EYPT	EyePoint, Inc.	2,825,000	$36,414,250
CRVS	Corvus Pharmaceuticals, Inc.	2,258,735	$33,045,293
CATX	Perspective Therapeutics, Inc.	6,336,782	$26,424,380
OCUL	Ocular Therapeutix, Inc	2,575,000	$21,810,250
IPSC	Century Therapeutics, Inc.	8,695,652	$19,652,173
ZURA	Zura Bio Ltd	3,250,000	$19,337,500
KPTI	Karyopharm Therapeutics Inc.	1,950,000	$10,861,500
ANTX	AN2 Therapeutics, Inc.	2,333,713	$7,981,298
HLXC	Helix Acquisition Corp. III	500,000	$5,080,000
RLMD	Relmada Therapeutics, Inc.	633,901	$4,411,950
No positions match the current search.

Sold Out

Positions the filer fully exited

8 positions

Ticker	Company	Shares	Value
TERN	Terns Pharmaceuticals, Inc.	1,475,000	$59,590,000
ORKA	Oruka Therapeutics, Inc.	1,753,054	$53,135,066
PTGX	Protagonist Therapeutics, Inc	450,000	$39,303,000
CTMX	CytomX Therapeutics, Inc.	7,692,300	$32,769,198
CNTA	Centessa Pharmaceuticals plc	1,000,000	$25,010,000
REPL	Replimune Group, Inc.	1,425,000	$13,851,000
CTNM	Contineum Therapeutics, Inc.	816,326	$9,330,606
DRUG	Bright Minds Biosciences Inc.	18,851	$1,471,132
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

36 positions · $1,728,452,363 total · as of Mar 31, 2026

All sectors Financial Services Healthcare

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
RLAY	Relay Therapeutics, Inc. Healthcare	Held	17,000,000	0	$169,150,000	+17.6%	9.79%
ALKS	Alkermes plc. Healthcare	Added	4,200,000	+650,000	$148,512,000	+49.5%	8.59%
ELVN	Enliven Therapeutics, Inc. Healthcare	Reduced	3,275,000	-1,417,809	$128,380,000	+77.6%	7.43%
COGT	Cogent Biosciences, Inc. Healthcare	Added	2,888,007	+691,162	$111,159,389	+42.5%	6.43%
SYRE	Spyre Therapeutics, Inc. Healthcare	Reduced	1,912,380	-475,865	$96,460,447	+23.3%	5.58%
TYRA	Tyra Biosciences, Inc. Healthcare	Reduced	2,475,000	-900,000	$94,792,500	+6.8%	5.48%
CLDX	Celldex Therapeutics, Inc. Healthcare	Added	2,696,616	+131,616	$85,536,659	+22.8%	4.95%
NUVL	Nuvalent, Inc. Healthcare	Added	833,600	+283,600	$85,402,320	+54.4%	4.94%
AMLX	Amylyx Pharmaceuticals, Inc. Healthcare	Held	5,650,000	0	$78,535,000	+15.1%	4.54%
KYMR	Kymera Therapeutics, Inc. Healthcare	Held	750,000	0	$62,467,500	+7.0%	3.61%
ANRO	Alto Neuroscience, Inc. Healthcare	Added	2,723,196	+900,000	$61,217,446	+88.6%	3.54%
PHVS	Pharvaris N.V. Healthcare	Added	1,918,970	+29,525	$54,210,902	+3.4%	3.14%
ERAS	Erasca, Inc. Healthcare	NEW	3,175,000	NEW	$51,371,500	NEW	2.97%
DMRA	Damora Therapeutics, Inc. Healthcare	NEW	1,939,000	NEW	$50,220,100	NEW	2.91%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Reduced	825,000	-975,000	$47,973,750	−40.5%	2.78%
DFTX	Definium Therapeutics, Inc. Healthcare	NEW	2,000,000	NEW	$37,800,000	NEW	2.19%
LBRX	Lb Pharmaceuticals Inc Healthcare	Held	1,500,000	0	$36,990,000	+10.8%	2.14%
EYPT	EyePoint, Inc. Healthcare	NEW	2,825,000	NEW	$36,414,250	NEW	2.11%
NRIX	Nurix Therapeutics, Inc. Healthcare	Held	2,275,000	0	$35,262,500	−18.3%	2.04%
CRVS	Corvus Pharmaceuticals, Inc. Healthcare	NEW	2,258,735	NEW	$33,045,293	NEW	1.91%
ASMB	Assembly Biosciences, Inc. Healthcare	Held	1,000,000	0	$27,750,000	−18.4%	1.61%
CATX	Perspective Therapeutics, Inc. Healthcare	NEW	6,336,782	NEW	$26,424,380	NEW	1.53%
SLNO	Soleno Therapeutics Inc Healthcare	Reduced	652,432	-547,568	$21,843,423	−60.7%	1.26%
OCUL	Ocular Therapeutix, Inc Healthcare	NEW	2,575,000	NEW	$21,810,250	NEW	1.26%
IPSC	Century Therapeutics, Inc. Healthcare	NEW	8,695,652	NEW	$19,652,173	NEW	1.14%
ZURA	Zura Bio Ltd Healthcare	NEW	3,250,000	NEW	$19,337,500	NEW	1.12%
SABS	SAB Biotherapeutics, Inc. Healthcare	Held	4,401,500	0	$16,857,745	+2.4%	0.98%
PALI	Palisade Bio, Inc. Healthcare	Reduced	7,181,062	-4,263,938	$12,566,858	−53.3%	0.73%
KPTI	Karyopharm Therapeutics Inc. Healthcare	NEW	1,950,000	NEW	$10,861,500	NEW	0.63%
IKT	Inhibikase Therapeutics, Inc. Healthcare	Held	5,397,488	0	$9,067,779	−18.0%	0.52%
ANTX	AN2 Therapeutics, Inc. Healthcare	NEW	2,333,713	NEW	$7,981,298	NEW	0.46%
PEPG	PepGen Inc. Healthcare	Added	4,475,000	+1,075,000	$7,920,750	−64.2%	0.46%
AVTX	Avalo Therapeutics, Inc. Healthcare	Held	483,000	0	$7,211,190	−17.8%	0.42%
HLXC	Helix Acquisition Corp. III Financial Services	NEW	500,000	NEW	$5,080,000	NEW	0.29%
LONA	LeonaBio, Inc. Healthcare	Held	464,398	0	$4,774,011	+35.8%	0.28%
RLMD	Relmada Therapeutics, Inc. Healthcare	NEW	633,901	NEW	$4,411,950	NEW	0.26%