DFTX · Definium Therapeutics, Inc.

$45.40 -0.42 (-0.92%) At close · Aug 20

Market Cap

$6.05B

134.37M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Quarter:

Holders: 366

Total Value: $5,621,143,434

Total Shares: 119,497,128

Institutional Ownership Trend

3 quarters

Superinvestors Holding DFTX

All superinvestors →

Stanley Druckenmiller $16,774,464 Joel Greenblatt $207,540

Holder Concentration

Across 366 13F filers · Δ vs Mar 31, 2026

Top Holder

9.4%

−1.2 pts

Top 5

30.3%

−2.1 pts

Top 10

46.3%

−0.2 pts

HHI

306

Broadly held−32

Quarterly Activity

vs Mar 31, 2026

New

151

Increased

121

Decreased

Sold Out

Unchanged

Holder count: +116

Institutional value: +272.2%

Shares held: +49.5%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega PRICE T ROWE ASSOCIATES INC /MD/	+4,582,031	4,652,032
Mega FMR LLC	+2,943,311	4,752,921
Mega BlackRock, Inc.	+2,752,604	11,232,834
Large Avoro Capital Advisors LLC	+2,188,888	7,188,888
Mega ALLIANCEBERNSTEIN L.P.	+1,711,584	1,803,287

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mid ArrowMark Colorado Holdings LLC	−1,030,648	564,069
Large Candriam S.C.A.	−679,204	614,425
Small Catalio Capital Management, LP	−475,312	562,672
Mega MILLENNIUM MANAGEMENT LLC	−470,820	376,076
Mid ORBIMED ADVISORS LLC	−438,600	365,400

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Jupiter Topco LLC	5,615,645	$264,159,940
Mega Capital World Investors	5,367,723	$252,497,689
Mega Capital International Investors	2,963,410	$139,398,806
Large RA CAPITAL MANAGEMENT, L.P.	1,500,000	$70,560,000
Large Polar Capital Holdings Plc	777,253	$36,561,981

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega JANUS HENDERSON GROUP PLC	3,556,041	$67,209,174
Small Trails Edge Capital Partners, LP	1,738,110	$32,850,279
Small Patient Square Capital LP	331,000	$6,255,900
Small Soviero Asset Management, LP	140,000	$2,646,000
Large Squarepoint Ops LLC	125,522	$2,372,365

Filter: New 151 Increased 121 Reduced 62 Sold out 35 Unchanged 32

Showing 100 of 385

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

BlackRock, Inc.

$528,392,505

9.40%

11,232,834

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	124,598	$5,861,089	1.1%	Sole
BlackRock Investment Management (Australia) Ltd	292	$13,735	0.0%	Sole
BlackRock Asset Management Canada Ltd	24,806	$1,166,874	0.2%	Sole
BlackRock Investment Management, LLC	367,777	$17,300,230	3.3%	Sole
BLACKROCK ADVISORS LLC	446,135	$20,986,190	4.0%	Sole
BlackRock Fund Advisors	6,053,405	$284,752,171	53.9%	Sole
BlackRock Institutional Trust Company, N.A.	3,880,023	$182,516,281	34.5%	Sole
BlackRock Fund Managers Ltd.	20,179	$949,220	0.2%	Sole
BlackRock Investment Management (UK) Ltd.	32,163	$1,512,947	0.3%	Sole
BlackRock (Netherlands) B.V.	5,529	$260,084	0.0%	Sole
BlackRock Asset Management Ireland Ltd	257,752	$12,124,654	2.3%	Sole
BlackRock (Luxembourg) S.A.	556	$26,154	0.0%	Sole
BlackRock Asset Management Schweiz AG	18,999	$893,712	0.2%	Sole
Aperio Group, LLC	620	$29,164	0.0%	Sole

Avoro Capital Advisors LLC

$338,165,291

6.02%

7,188,888

Driehaus Capital Management LLC

$322,001,783

5.73%

6,845,276

Jupiter Topco LLC

$264,159,940

4.70%

5,615,645

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	62,952	$2,961,262	1.1%	Defined
JANUS HENDERSON INVESTORS US LLC	5,552,693	$261,198,678	98.9%	Defined

Capital World Investors

$252,497,689

4.49%

5,367,723

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	5,367,723	$252,497,689	100.0%	Defined

FMR LLC

$223,577,403

3.98%

4,752,921

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	4,005,833	$188,434,384	84.3%	Defined
FIDELITY MANAGEMENT TRUST CO	686,300	$32,283,552	14.4%	Defined
STRATEGIC ADVISERS LLC	1,310	$61,622	0.0%	Defined
Fidelity Institutional Asset Management Trust Co	47,800	$2,248,512	1.0%	Defined
FIAM LLC	11,678	$549,333	0.2%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$218,831,585

3.89%

4,652,032

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	127,578	$6,001,269	2.7%	Defined
Held directly	4,524,454	$212,830,316	97.3%	Sole

GEODE CAPITAL MANAGEMENT, LLC

$171,452,003

3.05%

3,644,813

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	479,184	$22,540,815	13.1%	Defined
Held directly	3,165,629	$148,911,188	86.9%	Defined

STATE STREET CORP

$144,195,945

2.57%

3,065,390

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	3,065,390	$144,195,945	100.0%	Defined

Capital International Investors

$139,398,806

2.48%

2,963,410

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CAPITAL GROUP COMPANIES INC joint	2,963,410	$139,398,806	100.0%	Defined

Octagon Capital Advisors LP

$138,768,000

2.47%

2,950,000

WELLINGTON MANAGEMENT GROUP LLP

$138,755,484

2.47%

2,949,734

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	2,217,137	$104,294,124	75.2%	Defined
Wellington Managment Canada LLC	15,921	$748,923	0.5%	Defined
Wellington Management Hong Kong Ltd	654	$30,764	0.0%	Defined
Wellington Management Singapore Pte. Ltd.	69,304	$3,260,060	2.3%	Defined
Wellington Management International Ltd	61,001	$2,869,487	2.1%	Defined
Wellington Trust Company, NA joint	559,117	$26,300,863	19.0%	Defined
Wellington Management Australia Pty Ltd	24,186	$1,137,709	0.8%	Defined
Wellington Management Europe GmbH	2,414	$113,554	0.1%	Defined

Deep Track Capital, LP

$129,360,000

2.30%

2,750,000

Commodore Capital LP

$94,080,000

1.67%

2,000,000

ALLIANCEBERNSTEIN L.P.

$84,826,620

1.51%

1,803,287

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	1,803,287	$84,826,620	100.0%	Defined

GOLDMAN SACHS GROUP INC

$84,712,075

1.51%

1,800,852

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	1,046,491	$49,226,936	58.1%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	742,165	$34,911,441	41.2%	Defined
GOLDMAN SACHS INTERNATIONAL	7,173	$337,417	0.4%	Defined
Goldman Sachs Trust Company, N.A. joint	5,023	$236,281	0.3%	Other

CITADEL ADVISORS LLC

$79,431,131

1.41%

1,688,587

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	761,215	$35,807,553	45.1%	Defined
Held directly	927,372	$43,623,578	54.9%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$77,541,959

1.38%

1,648,426

RA CAPITAL MANAGEMENT, L.P.

$70,560,000

1.26%

1,500,000

VANGUARD CAPITAL MANAGEMENT LLC

$69,922,796

1.24%

1,486,454

Siren, L.L.C.

$66,772,950

1.19%

1,419,493

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invus Group, LLC	1,419,493	$66,772,950	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$65,216,256

1.16%

1,386,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	1,386,400	$65,216,256	100.0%	Other

MARSHALL WACE, LLP

$61,102,419

1.09%

1,298,946

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	1,298,946	$61,102,419	100.0%	Other

NORTHERN TRUST CORP

$55,000,951

0.98%

1,169,238

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	1,085,446	$51,059,378	92.8%	Defined
NORTHERN TRUST GLOBAL INVESTMENTS LTD	63,596	$2,991,554	5.4%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	20,196	$950,019	1.7%	Other

AMERIPRISE FINANCIAL INC

$54,018,993

0.96%

1,148,363

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Columbia Management Investment Advisers, LLC joint	875,539	$41,185,353	76.2%	Defined
Threadneedle Asset Management Holdings LTD	266,926	$12,556,199	23.2%	Defined
Ameriprise Financial Services, LLC	5,898	$277,441	0.5%	Defined

Nuveen, LLC

$51,993,969

0.92%

1,105,314

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	67,588	$3,179,339	6.1%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	226,324	$10,646,280	20.5%	Defined
TEACHERS ADVISORS, LLC joint	811,402	$38,168,350	73.4%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$50,971,415

0.91%

1,083,576

Woodline Partners LP

$47,211,272

0.84%

1,003,641

ADAGE CAPITAL PARTNERS GP, L.L.C.

$47,040,000

0.84%

1,000,000

Boxer Capital Management, LLC

$46,969,440

0.84%

998,500

TWO SIGMA INVESTMENTS, LP

$43,362,318

0.77%

921,818

Balyasny Asset Management L.P.

$42,225,832

0.75%

897,658

VANGUARD FIDUCIARY TRUST CO

$38,934,678

0.69%

827,693

Holocene Advisors, LP

$37,470,840

0.67%

796,574

AWM Investment Company, Inc.

$36,916,992

0.66%

784,800

Bank of New York Mellon Corp

$36,562,823

0.65%

777,271

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	114,097	$5,367,122	14.7%	Defined
BNY Mellon Securities Corporation	10,512	$494,484	1.4%	Defined
The Bank of New York Mellon	250,196	$11,769,219	32.2%	Defined
BNY Mellon, NA joint	2,751	$129,407	0.4%	Defined
BNY Mellon Advisors, Inc. joint	3,131	$147,282	0.4%	Other
Newton Investment Management North America, LLC joint	396,505	$18,651,593	51.0%	Defined
Held directly	79	$3,716	0.0%	Defined

Polar Capital Holdings Plc

$36,561,981

0.65%

777,253

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Polar Capital LLP	777,253	$36,561,981	100.0%	Defined

EVENTIDE ASSET MANAGEMENT, LLC

$33,398,400

0.59%

710,000

NEUBERGER BERMAN GROUP LLC

$32,341,834

0.58%

687,539

Qube Research & Technologies Ltd

$32,123,663

0.57%

682,901

Candriam S.C.A.

$28,902,552

0.51%

614,425

ArrowMark Colorado Holdings LLC

$26,533,805

0.47%

564,069

Catalio Capital Management, LP

$26,468,090

0.47%

562,672

Blackstone Inc.

$26,418,228

0.47%

561,612

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blackstone Alternative Asset Management L.P.	561,612	$26,418,228	100.0%	Other

Integral Health Asset Management, LLC

$25,872,000

0.46%

550,000

BAMCO INC /NY/

$24,465,880

0.44%

520,108

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARON CAPITAL MANAGEMENT INC /NY/ joint	520,108	$24,465,880	100.0%	Defined

UBS Group AG

$23,494,926

0.42%

499,467

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	1,380	$64,915	0.3%	Defined
UBS AG	489,414	$23,022,034	98.0%	Defined
UBS Switzerland AG	8,673	$407,977	1.7%	Defined

FRANKLIN RESOURCES INC

$22,871,741

0.41%

486,219

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FRANKLIN ADVISERS INC	486,219	$22,871,741	100.0%	Defined

Point72 Asset Management, L.P.

$22,766,419

0.41%

483,980

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$22,155,840

0.39%

471,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	471,000	$22,155,840	100.0%	Other

Ensign Peak Advisors, Inc

$21,925,626

0.39%

466,106

MORGAN STANLEY

$21,399,056

0.38%

454,912

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	3,647	$171,554	0.8%	Defined
MORGAN STANLEY & CO. LLC	107,794	$5,070,629	23.7%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	138,270	$6,504,220	30.4%	Defined
MORGAN STANLEY AIP GP LP	12,201	$573,935	2.7%	Defined
MORGAN STANLEY SMITH BARNEY LLC	71,289	$3,353,434	15.7%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	121,711	$5,725,284	26.8%	Defined

GREAT POINT PARTNERS LLC

$19,992,000

0.36%

425,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JAY JEFFREY R joint	425,000	$19,992,000	100.0%	Defined

JANE STREET GROUP, LLC

$19,940,256

0.35%

423,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	423,900	$19,940,256	100.0%	Defined

Ally Bridge Group (NY) LLC

$18,816,000

0.33%

400,000

SILVERARC CAPITAL MANAGEMENT, LLC

$18,816,000

0.33%

400,000

RTW INVESTMENTS, LP

$18,816,000

0.33%

400,000

Cormorant Asset Management, LP

$18,816,000

0.33%

400,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Chen Bihua	400,000	$18,816,000	100.0%	Defined

ASSETMARK, INC

$18,653,335

0.33%

396,542

Caption Management, LLC

$17,503,584

0.31%

372,100

ORBIMED ADVISORS LLC

$17,188,416

0.31%

365,400

Duquesne Family Office LLC

$16,774,464

0.30%

356,600

JANE STREET GROUP, LLC

$15,415,008

0.27%

327,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	327,700	$15,415,008	100.0%	Defined

D. E. Shaw & Co., Inc.

$14,836,885

0.26%

315,410

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	240,289	$11,303,194	76.2%	Defined
D. E. Shaw Investment Management, L.L.C. joint	75,121	$3,533,691	23.8%	Defined

SILVERBACK ASSET MANAGEMENT LLC

$13,848,576

0.25%

294,400

CITADEL ADVISORS LLC

$13,547,520

0.24%

288,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	288,000	$13,547,520	100.0%	Defined

Tetragon Partners GP Ltd

$13,500,009

0.24%

286,990

CITADEL ADVISORS LLC

$13,382,880

0.24%

284,500

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	284,500	$13,382,880	100.0%	Defined

MILLENNIUM MANAGEMENT LLC

$12,516,215

0.22%

266,076

JPMORGAN CHASE & CO

$12,510,521

0.22%

265,955

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
J.P. Morgan Trust Co of Delaware	896	$42,147	0.3%	Other
JPMorgan Chase Bank, N.A.	66,679	$3,136,580	25.1%	Defined
J.P. Morgan Investment Management Inc.	194,212	$9,135,732	73.0%	Defined
J.P. Morgan Securities LLC	4,161	$195,733	1.6%	Defined
J.P. Morgan Securities plc	7	$329	0.0%	Defined

Sofinnova Investments, Inc.

$12,037,677

0.21%

255,903

PFM Health Sciences, LP

$11,713,900

0.21%

249,020

HighVista Strategies LLC

$11,425,263

0.20%

242,884

Trexquant Investment LP

$10,969,680

0.20%

233,199

SEVEN GRAND MANAGERS, LLC

$10,584,000

0.19%

225,000

Swiss National Bank

$10,405,248

0.19%

221,200

Eversept Partners, LP

$10,216,382

0.18%

217,185

UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC

$9,934,045

0.18%

211,183

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Group AG	2,413	$113,507	1.1%	Defined
UBS Asset Management Switzerland AG	166,435	$7,829,102	78.8%	Sole
UBS Asset Management (UK) Ltd.	23,521	$1,106,427	11.1%	Other
Held directly	18,814	$885,009	8.9%	Sole

TD Asset Management Inc

$9,852,998

0.18%

209,460

ROYCE & ASSOCIATES LP

$9,810,239

0.17%

208,551

SEB Asset Management AB

$9,796,268

0.17%

208,254

SUPERSTRING CAPITAL MANAGEMENT LP

$8,856,785

0.16%

188,282

EMERALD ADVISERS, LLC

$8,408,447

0.15%

178,751

Aberdeen Group plc

$8,232,000

0.15%

175,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	175,000	$8,232,000	100.0%	Defined

BANK OF AMERICA CORP /DE/

$7,741,606

0.14%

164,575

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	122,190	$5,747,817	74.2%	Defined
BOFA SECURITIES, INC.	27,892	$1,312,039	16.9%	Defined
MANAGED ACCOUNT ADVISORS LLC	14,493	$681,750	8.8%	Defined

Tri Locum Partners LP

$7,667,331

0.14%

162,996

RHUMBLINE ADVISERS

$7,436,835

0.13%

158,096

Brevan Howard Capital Management LP

$7,376,435

0.13%

156,812

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard Investment Products Ltd	143,498	$6,750,145	91.5%	Defined
Brevan Howard US Investment Management, LP	13,314	$626,290	8.5%	Defined

Russell Investments Group, Ltd.

$7,219,556

0.13%

153,477

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	119,336	$5,613,565	77.8%	Defined
Russell Investments Capital, LLC	15,820	$744,172	10.3%	Defined
Russell Investments France SAS	8,537	$401,580	5.6%	Defined
Russell Investments Trust Company	9,784	$460,239	6.4%	Defined

LMR Partners LLP

$7,065,408

0.13%

150,200

Seven Fleet Capital Management LP

$6,992,354

0.12%

148,647

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$6,885,150

0.12%

146,368

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	146,368	$6,885,150	100.0%	Defined

Rock Springs Capital Management LP

$6,735,516

0.12%

143,187

DEUTSCHE BANK AG\

$6,724,226

0.12%

142,947

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	3,282	$154,385	2.3%	Defined
DWS Investments UK Ltd	139,665	$6,569,841	97.7%	Defined

SummitTX Capital, L.P.

$6,702,682

0.12%

142,489

STEMPOINT CAPITAL LP

$6,450,312

0.11%

137,124

AQR CAPITAL MANAGEMENT LLC

$6,310,507

0.11%

134,152

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Petros Family Wealth, LLC	8	$376	0.0%	Other
Compound Planning, Inc.	9	$423	0.0%	Other
Arax Advisory Partners	169	$7,949	0.1%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	120	$5,644	0.1%	Other
Stokes Family Office, LLC	18	$846	0.0%	Other
Held directly	133,828	$6,295,269	99.8%	Defined

BIT Capital GmbH

$6,027,282

0.11%

128,131

FRED ALGER MANAGEMENT, LLC

$5,892,042

0.10%

125,256

WELLS FARGO & COMPANY/MN

$5,740,431

0.10%

122,033

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	118,724	$5,584,776	97.3%	Defined
WELLS FARGO CLEARING SERVICES, LLC	3,228	$151,845	2.6%	Defined
WELLS FARGO INVESTMENT INSTITUTE, INC.	81	$3,810	0.1%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Atika Capital Partners LP	71,176	$3,348,119	58.3%	Defined
Optika Master Portfolio Ltd	30,824	$1,449,960	25.3%	Other
Held directly	20,000	$940,800	16.4%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HSBC Global Asset Management (UK) Ltd	2,482	$116,753	2.1%	Defined
HSBC GLOBAL ASSET MANAGEMENT (FRANCE)	115,000	$5,409,600	97.9%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	3,910	$183,926	3.9%	Defined
RBC Capital Markets, LLC	75,093	$3,532,374	75.0%	Defined
RBC Dominion Securities Inc.	20,401	$959,663	20.4%	Defined
RBC Phillips, Hager & North Investment Counsel Inc.	159	$7,479	0.2%	Defined
RBC Private Counsel (USA) Inc.	500	$23,520	0.5%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	95,166	$4,476,608	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	19,928	$937,412	21.8%	Defined
Invesco Trust Co joint	51,364	$2,416,162	56.2%	Defined
Invesco Capital Management LLC	20,046	$942,963	21.9%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	84,393	$3,969,846	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	79,547	$3,741,890	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	75,859	$3,568,407	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	12,635	$594,350	17.1%	Defined
Legal & General Investment Management Ltd joint	61,369	$2,886,797	82.9%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ROCKEFELLER FINANCIAL LLC	70,111	$3,298,021	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS CAPITAL INC.	68,900	$3,241,056	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	59,936	$2,819,389	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	36,510	$1,717,430	72.6%	Defined
BARCLAYS CAPITAL INC.	13,786	$648,493	27.4%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ALLSTATE INVESTMENTS LLC	45,639	$2,146,858	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Prudential Financial Inc	45,375	$2,134,440	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	40,954	$1,926,476	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	38,386	$1,805,677	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TORONTO DOMINION BANK	36,694	$1,726,085	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF NOVA SCOTIA	34,722	$1,633,322	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ELEVATION POINT WEALTH PARTNERS, LLC	11,778	$554,037	38.3%	Other
Held directly	18,951	$891,455	61.7%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PEAK6 Investments LLC joint	30,000	$1,411,200	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	1,820	$85,612	6.4%	Sole
SEI TRUST CO	26,762	$1,258,884	93.6%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLINGTON SMALL CAP EQUITY	24,500	$1,152,480	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	11,826	$556,295	52.8%	Defined
Raymond James Financial Services Advisors, Inc.	10,575	$497,448	47.2%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T3 Global Trading, LLC	17,500	$823,200	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CARY STREET PARTNERS INVESTMENT ADVISORY LLC	15,582	$732,977	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	15,500	$729,120	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Amundi Asset Management	14,068	$661,758	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dymon Asia Capital (HK) Ltd	13,289	$625,114	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STIFEL NICOLAUS & CO INC \MO\	8,850	$416,304	72.4%	Defined
1919 Investment Counsel, LLC	3,301	$155,279	27.0%	Defined
Held directly	74	$3,480	0.6%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	11,477	$539,878	96.0%	Defined
Osaic Advisory Services, LLC	475	$22,344	4.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	11,736	$552,061	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T3 Global Trading, LLC	11,500	$540,960	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMO Family Office, LLC	1,188	$55,883	11.8%	Defined
BMO NESBITT BURNS INC.	8,842	$415,927	88.2%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	9,230	$434,179	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Desjardins Securities inc.	8,544	$401,909	93.8%	Defined
Held directly	560	$26,342	6.2%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PEAK6 Investments LLC joint	9,000	$423,360	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PNC Bank, National Association	8,569	$403,084	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Bellevue Asset Management AG	8,391	$394,712	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	8,295	$390,196	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CIBC Private Wealth Advisors, Inc.	447	$21,026	5.8%	Defined
CIBC National Trust Co	79	$3,716	1.0%	Defined
CIBC WORLD MARKETS CORP	7,185	$337,982	93.2%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jump Trading Holdings, LLC	7,064	$332,290	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marex Financial	6,771	$318,507	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	6,308	$296,728	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EVOKE WEALTH, LLC	4,651	$218,783	81.8%	Defined
Held directly	1,035	$48,686	18.2%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DNB FUND	4,480	$210,739	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
KBC Bank NV joint	3,310	$155,702	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fifth Third Bank, National Association	3,300	$155,232	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BNP PARIBAS ASSET MANAGEMENT Europe	1,711	$80,485	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
US BANK NATIONAL ASSOCIATION	1,283	$60,351	100.0%	Other

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
National Bank Financial Inc.	1,265	$59,505	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nykredit Bank A/S	947	$44,546	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Atlantic Union Bankshares Corp	776	$36,503	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Edward D. Jones & Co., L.P.	677	$31,846	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Optiver VOF	624	$29,352	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BMSS Wesson Wealth Solutions, LLC	39	$1,834	13.9%	Sole
Held directly	242	$11,383	86.1%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TORONTO DOMINION BANK	43	$2,022	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	36,442	$688,753	1.0%	Defined
JANUS HENDERSON INVESTORS US LLC	3,519,599	$66,520,421	99.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	125,522	$2,372,365	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Virtu Americas LLC	14,460	$273,294	100.0%	Defined

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Institutional Asset Management Trust Co	3	$56	0.1%	Sole
Held directly	2,656	$50,198	99.9%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ANCORA PRIVATE WEALTH ADVISORS, LLC	251	$4,743	100.0%	Sole

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
FEDERATED MDTA LLC	207	$3,912	100.0%	Defined

Key facts CIK 1813814 CUSIP 24477V105 13F (30d) 346 filings 342 filers Visit website Investor relations