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Equibles

KPTI

Karyopharm Therapeutics Inc.

Company with tickers: KPTI

CIK
1503802
CUSIP
48576U205
Shares Outstanding
22,662,943
13F Activity (30d)
78 filings 76 filers

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Holders: 83
Total Value: $140,763,609
Total Shares: 25,271,751

Institutional Ownership Trend

5 quarters

Holder Concentration

Across 83 13F filers · Δ vs Dec 31, 2025
Top Holder
10.2%
Mar 2025 → Mar 2026 · range 10.2% – 20.3%
−4.3 pts
Top 5
38.7%
Mar 2025 → Mar 2026 · range 38.7% – 59.1%
−6.8 pts
Top 10
58.9%
Mar 2025 → Mar 2026 · range 58.9% – 78.3%
−6.2 pts
HHI
454
Mar 2025 → Mar 2026 · range 454 – 919
Broadly held −135

Quarterly Activity

vs Dec 31, 2025
New
29
Increased
34
Decreased
9
Sold Out
16
Unchanged
11
Holder count: +13
Institutional value: +85.2%
Shares held: +144.8%

Top Buyers

vs Dec 31, 2025
Institution Added Now Holds Open
Mid Ikarian Capital, LLC +2,028,881 2,573,435
Large ADAGE CAPITAL PARTNERS GP, L.L.C. +1,385,000 1,806,322
Small Catalio Capital Management, LP +754,725 897,709
Mid BOOTHBAY FUND MANAGEMENT, LLC +605,782 750,410
Mega JANE STREET GROUP, LLC +502,368 593,701

Top Sellers

vs Dec 31, 2025
Institution Sold Now Holds Open
Mid Affinity Asset Advisors, LLC −389,575 500,000
Mega BANK OF AMERICA CORP /DE/ −28,616 19,472
Small Persistent Asset Partners Ltd −17,706 610
Mid Davidson Kempner Capital Management LP −10,020 300,000
Small DAFNA Capital Management LLC −5,200 45,800

Top New Positions

vs Dec 31, 2025
Institution Acquired Value (USD) Open
Mid Commodore Capital LP 1,950,000 $10,861,500
Mid RA CAPITAL MANAGEMENT, L.P. 1,917,354 $10,679,661
Large Caption Management, LLC 1,181,900 $6,583,183
Mega GOLDMAN SACHS GROUP INC 947,579 $5,278,015
Small Squadron Capital Management LLC 750,000 $4,177,500

Top Sold-Out Positions

vs Dec 31, 2025
Institution Previously Held Last Value (USD) Open
Small Opaleye Management Inc. 930,000 $6,844,800
Mega VANGUARD GROUP INC 559,619 $4,118,795
Mid BRAIDWELL LP 303,370 $2,232,803
Small Exome Asset Management LLC 295,541 $2,175,181
Mega AMERIPRISE FINANCIAL INC 276,881 $2,037,844
Filter: New 29 Increased 34 Reduced 9 Sold out 16 Unchanged 11
Showing 100 of 100
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Mid Commodore Capital LP $10,861,500 7.72% 1,950,000
Mid RA CAPITAL MANAGEMENT, L.P. $10,679,661 7.59% 1,917,354
Large ADAGE CAPITAL PARTNERS GP, L.L.C. $10,061,213 7.15% 1,806,322
Mega T. Rowe Price Investment Management, Inc. $8,589,441 6.10% 1,542,090
Large Caption Management, LLC $6,054,033 4.30% 1,086,900
Mega GOLDMAN SACHS GROUP INC $5,278,015 3.75% 947,579
Mid Ikarian Capital, LLC $5,124,400 3.64% 920,000
Mid Ikarian Capital, LLC $5,124,400 3.64% 920,000
Small Catalio Capital Management, LP $5,000,239 3.55% 897,709
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $4,818,050 3.42% 865,000
Small Squadron Capital Management LLC $4,177,500 2.97% 750,000
Mega VANGUARD CAPITAL MANAGEMENT LLC $4,120,379 2.93% 739,745
Mid Ikarian Capital, LLC $4,085,232 2.90% 733,435
Mid Affinity Asset Advisors, LLC $2,785,000 1.98% 500,000
Mega JANE STREET GROUP, LLC $2,636,838 1.87% 473,400
Small Avidity Partners Management LP $2,583,037 1.84% 463,741
Mid Soleus Capital Management, L.P. $2,450,800 1.74% 440,000
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $2,372,263 1.69% 425,900
Mega MILLENNIUM MANAGEMENT LLC $2,342,580 1.66% 420,571
Small Boxer Capital Management, LLC $1,685,125 1.20% 302,536
Mid Davidson Kempner Capital Management LP $1,671,000 1.19% 300,000
Small ACORN CAPITAL ADVISORS, LLC $1,603,190 1.14% 287,826
Mid Eversept Partners, LP $1,538,289 1.09% 276,174
Mid BOOTHBAY FUND MANAGEMENT, LLC $1,494,431 1.06% 268,300
Mid BOOTHBAY FUND MANAGEMENT, LLC $1,494,431 1.06% 268,300
Mid Jump Financial, LLC $1,460,152 1.04% 262,146
Mega CITADEL ADVISORS LLC $1,438,174 1.02% 258,200
Large Trexquant Investment LP $1,436,519 1.02% 257,903
Small Ally Bridge Group (NY) LLC $1,392,500 0.99% 250,000
Mega CITADEL ADVISORS LLC $1,388,601 0.99% 249,300
Large ACADIAN ASSET MANAGEMENT LLC $1,386,690 0.99% 248,957
Mega BlackRock, Inc. $1,364,085 0.97% 244,899
Small DIADEMA PARTNERS LP $1,344,041 0.95% 241,300
Mid BOOTHBAY FUND MANAGEMENT, LLC $1,190,921 0.85% 213,810
Mid Brevan Howard Capital Management LP $1,182,884 0.84% 212,367
Mega GEODE CAPITAL MANAGEMENT, LLC $1,148,160 0.82% 206,133
Mid ADAR1 Capital Management, LLC $1,142,964 0.81% 205,200
Mega UBS Group AG $1,080,674 0.77% 194,017
Mid GROUP ONE TRADING LLC $1,066,805 0.76% 191,527
Mid XTX Topco Ltd $915,947 0.65% 164,443
Mega TWO SIGMA INVESTMENTS, LP $842,362 0.60% 151,232
Mid ADAR1 Capital Management, LLC $761,619 0.54% 136,736
Large MARSHALL WACE, LLP $715,471 0.51% 128,451
Mega VANGUARD FIDUCIARY TRUST CO Bank $640,182 0.45% 114,934
Mid Engineers Gate Manager LP $626,246 0.44% 112,432
Mega JANE STREET GROUP, LLC $589,868 0.42% 105,901
Large RENAISSANCE TECHNOLOGIES LLC $587,155 0.42% 105,414
Mid C WorldWide Group Holding A/S $557,000 0.40% 100,000
Small SILVERBACK ASSET MANAGEMENT LLC $557,000 0.40% 100,000
Large Balyasny Asset Management L.P. $557,000 0.40% 100,000
Large Caption Management, LLC $529,150 0.38% 95,000
Mega MILLENNIUM MANAGEMENT LLC $506,870 0.36% 91,000
Mega STATE STREET CORP $449,732 0.32% 80,742
Large Connor, Clark & Lunn Investment Management Ltd. $440,481 0.31% 79,081
Mid BRIDGEWAY CAPITAL MANAGEMENT, LLC $400,332 0.28% 71,873
Large Balyasny Asset Management L.P. $394,066 0.28% 70,748
Small SILVERBACK ASSET MANAGEMENT LLC $362,050 0.26% 65,000
Mega ROYAL BANK OF CANADA Bank $336,420 0.24% 60,399
Small Tetragon Partners GP Ltd $295,120 0.21% 52,984
Small Tetragon Partners GP Ltd $278,500 0.20% 50,000
Small DAFNA Capital Management LLC $255,106 0.18% 45,800
Mega NORTHERN TRUST CORP Bank $214,755 0.15% 38,556
Mid Zimmer Partners, LP $208,875 0.15% 37,500
Large Centiva Capital, LP $168,269 0.12% 30,210
Mid China Universal Asset Management Co., Ltd. $167,100 0.12% 30,000
Large Point72 Asset Management, L.P. $167,100 0.12% 30,000
Large Baird Financial Group, Inc. $165,935 0.12% 29,791
Mid Susquehanna Portfolio Strategies, LLC $139,366 0.10% 25,021
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $134,448 0.10% 24,138
Mid Eversept Partners, LP $132,566 0.09% 23,800
Mega BANK OF AMERICA CORP /DE/ Bank $108,459 0.08% 19,472
Large OMERS ADMINISTRATION Corp $108,058 0.08% 19,400
Mega MORGAN STANLEY $103,433 0.07% 18,570
Mega Invesco Ltd. $93,230 0.07% 16,738
Small Velan Capital Investment Management LP $83,550 0.06% 15,000
Mega JANE STREET GROUP, LLC $80,208 0.06% 14,400
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $74,799 0.05% 13,429
Mega HSBC HOLDINGS PLC $64,027 0.05% 11,495
Mega Bank of New York Mellon Corp Bank $63,492 0.05% 11,399
Mega PRICE T ROWE ASSOCIATES INC /MD/ $60,635 0.04% 10,886
Mega Vanguard Global Advisers, LLC $45,712 0.03% 8,207
Mega BARCLAYS PLC $41,351 0.03% 7,424
Mega CITIGROUP INC $27,521 0.02% 4,941
Large Centiva Capital, LP $20,052 0.01% 3,600
Large TD Waterhouse Canada Inc. $17,840 0.01% 3,203
Large Rockefeller Capital Management L.P. $4,082 0.00% 733
Mega FMR LLC $3,704 0.00% 665
Small Persistent Asset Partners Ltd $3,397 0.00% 610
Mega JPMORGAN CHASE & CO $2,623 0.00% 471
Large OSAIC HOLDINGS, INC. $2,238 0.00% 402
Mid HARBOUR INVESTMENTS, INC. $1,587 0.00% 285
Small Quent Capital, LLC $1,308 0.00% 235
Micro MB, LEVIS & ASSOCIATES, LLC $557 0.00% 100
Mega BNP PARIBAS ARBITRAGE, SA $467 0.00% 84
Mid SBI Securities Co., Ltd. Broker-Dealer $373 0.00% 67
Small Activest Wealth Management $367 0.00% 66
Mid Allworth Financial LP $144 0.00% 26
Mid Advisory Services Network, LLC $66 0.00% 12
Small West Branch Capital LLC $16 0.00% 3
Micro PlanVest Financial, Inc $5 0.00% 1

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