KPTI · Karyopharm Therapeutics Inc. · Holdings

$1.61 -0.01 (-0.62%) At close · Sep 11

Russell 2000 member Rebalance outlook locked

Market Cap

$36.52M

22.68M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 100

Total Value: $223,103,911

Total Shares: 22,835,616

Showing 1–100 of 110 holdings by value · page 1 of 2

Institutional Ownership Trend

26 quarters

Holder Concentration

Across 100 13F filers · Δ vs Mar 31, 2026

Top Holder

8.4%

−1.8 pts

Top 5

34.2%

−4.4 pts

Top 10

53.0%

−5.7 pts

HHI

375

Broadly held−76

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +16

Institutional value: +58.0%

Shares held: -9.9%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Small ACORN CAPITAL ADVISORS, LLC	+1,230,287	1,518,113
Mega BlackRock, Inc.	+1,173,900	1,418,799
Mega TWO SIGMA INVESTMENTS, LP	+544,032	695,264
Mega GOLDMAN SACHS GROUP INC	+477,079	1,424,658
Small Avidity Partners Management LP	+460,746	924,487

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Large Caption Management, LLC	−803,700	378,200
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP	−769,338	545,700
Mega T. Rowe Price Investment Management, Inc.	−755,781	786,309
Mega JANE STREET GROUP, LLC	−507,428	86,273
Mega CITADEL ADVISORS LLC	−389,531	117,969

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Small Kalehua Capital Management LLC	685,644	$6,698,741
Mid NEA Management Company, LLC	576,780	$5,635,140
Mid Ghisallo Capital Management LLC	500,000	$4,885,000
Small SILVERARC CAPITAL MANAGEMENT, LLC	297,460	$2,906,184
Small DLD Asset Management, LP	181,600	$1,774,232

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Small Ikarian Capital, LLC	2,573,435	$14,334,032
Mid Commodore Capital LP	1,950,000	$10,861,500
Mid BOOTHBAY FUND MANAGEMENT, LLC	750,410	$4,179,783
Small Squadron Capital Management LLC	750,000	$4,177,500
Mid ADAR1 Capital Management, LLC	341,936	$1,904,583

Filter: New 33 Increased 32 Reduced 18 Sold out 17 Unchanged 17

Showing 100 of 110

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

RA CAPITAL MANAGEMENT, L.P.

$18,732,548

8.40%

1,917,354

ADAGE CAPITAL PARTNERS GP, L.L.C.

$14,863,315

6.66%

1,521,322

ACORN CAPITAL ADVISORS, LLC

$14,831,964

6.65%

1,518,113

GOLDMAN SACHS GROUP INC

$13,918,908

6.24%

1,424,658

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	1,388,694	$13,567,540	97.5%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	35,964	$351,368	2.5%	Defined

BlackRock, Inc.

$13,861,664

6.21%

1,418,799

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	86,170	$841,880	6.1%	Sole
BlackRock Investment Management, LLC	57,532	$562,087	4.1%	Sole
BLACKROCK ADVISORS LLC	47,160	$460,753	3.3%	Sole
BlackRock Fund Advisors	793,291	$7,750,453	55.9%	Sole
BlackRock Institutional Trust Company, N.A.	434,599	$4,246,032	30.6%	Sole
Aperio Group, LLC	47	$459	0.0%	Sole

VANGUARD CAPITAL MANAGEMENT LLC

$9,369,224

4.20%

958,979

Catalio Capital Management, LP

$9,192,153

4.12%

940,855

Avidity Partners Management LP

$9,032,237

4.05%

924,487

T. Rowe Price Investment Management, Inc.

$7,682,238

3.44%

786,309

TWO SIGMA INVESTMENTS, LP

$6,792,729

3.04%

695,264

Kalehua Capital Management LLC

$6,698,741

3.00%

685,644

NEA Management Company, LLC

$5,635,140

2.53%

576,780

GEODE CAPITAL MANAGEMENT, LLC

$5,190,126

2.33%

531,231

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	87,955	$859,320	16.6%	Defined
Held directly	443,276	$4,330,806	83.4%	Defined

Ghisallo Capital Management LLC

$4,885,000

2.19%

500,000

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$4,736,496

2.12%

484,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	484,800	$4,736,496	100.0%	Other

Soleus Capital Management, L.P.

$4,298,800

1.93%

440,000

UBS Group AG

$3,454,134

1.55%

353,545

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	353,541	$3,454,095	100.0%	Defined
UBS Securities LLC	4	$39	0.0%	Defined

STATE STREET CORP

$3,184,932

1.43%

325,991

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SSGA FUNDS MANAGEMENT, INC. joint	325,991	$3,184,932	100.0%	Defined

Affinity Asset Advisors, LLC

$3,053,125

1.37%

312,500

Brevan Howard Capital Management LP

$3,026,912

1.36%

309,817

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Brevan Howard Investment Products Ltd	309,817	$3,026,912	100.0%	Defined

MILLENNIUM MANAGEMENT LLC

$2,986,454

1.34%

305,676

Boxer Capital Management, LLC

$2,955,776

1.32%

302,536

Davidson Kempner Capital Management LP

$2,931,000

1.31%

300,000

ACADIAN ASSET MANAGEMENT LLC

$2,921,200

1.31%

298,997

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	298,997	$2,921,200	100.0%	Defined

SILVERARC CAPITAL MANAGEMENT, LLC

$2,906,184

1.30%

297,460

Caption Management, LLC

$2,791,289

1.25%

285,700

Eversept Partners, LP

$2,698,219

1.21%

276,174

Tetragon Partners GP Ltd

$2,445,431

1.10%

250,300

JPMORGAN CHASE & CO

$2,028,338

0.91%

207,609

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	8,257	$80,670	4.0%	Defined
J.P. Morgan Securities LLC	199,352	$1,947,668	96.0%	Defined

MORGAN STANLEY

$1,978,480

0.89%

202,506

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	20	$195	0.0%	Defined
MORGAN STANLEY & CO. LLC	5,540	$54,125	2.7%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	183,345	$1,791,280	90.5%	Defined
MORGAN STANLEY SMITH BARNEY LLC	13,364	$130,565	6.6%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	237	$2,315	0.1%	Defined

Trexquant Investment LP

$1,840,355

0.82%

188,368

BNP PARIBAS ARBITRAGE, SA

$1,837,131

0.82%

188,038

BARCLAYS PLC

$1,620,881

0.73%

165,904

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	163,967	$1,601,957	98.8%	Defined
BARCLAYS CAPITAL INC.	1,937	$18,924	1.2%	Defined

NORTHERN TRUST CORP

$1,563,258

0.70%

160,006

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	156,890	$1,532,815	98.1%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	3,116	$30,443	1.9%	Other

VANGUARD FIDUCIARY TRUST CO

$1,420,567

0.64%

145,401

VANGUARD PORTFOLIO MANAGEMENT LLC

$1,317,171

0.59%

134,818

MARSHALL WACE, LLP

$1,254,965

0.56%

128,451

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	128,451	$1,254,965	100.0%	Other

RENAISSANCE TECHNOLOGIES LLC

$1,057,250

0.47%

108,214

DLD Asset Management, LP

$991,655

0.44%

101,500

C WorldWide Group Holding A/S

$977,000

0.44%

100,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 2	100,000	$977,000	100.0%	Defined

SILVERBACK ASSET MANAGEMENT LLC

$977,000

0.44%

100,000

Jump Financial, LLC

$918,380

0.41%

94,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Leap GP LLC joint	94,000	$918,380	100.0%	Defined

Caption Management, LLC

$903,725

0.41%

92,500

Invesco Ltd.

$882,268

0.40%

90,304

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	2,596	$25,362	2.9%	Defined
Invesco Trust Co joint	7,942	$77,593	8.8%	Defined
Invesco Capital Management LLC	79,766	$779,313	88.3%	Defined

DLD Asset Management, LP

$782,577

0.35%

80,100

Connor, Clark & Lunn Investment Management Ltd.

$746,398

0.33%

76,397

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	76,397	$746,398	100.0%	Sole

BRIDGEWAY CAPITAL MANAGEMENT, LLC

$702,199

0.31%

71,873

J. Goldman & Co LP

$660,452

0.30%

67,600

J. Goldman & Co LP

$659,475

0.30%

67,500

Squarepoint Ops LLC

$623,335

0.28%

63,801

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	63,801	$623,335	100.0%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$605,183

0.27%

61,943

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$594,993

0.27%

60,900

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	60,900	$594,993	100.0%	Other

ROYAL BANK OF CANADA

$590,400

0.26%

60,430

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RBC CMA LTD.	625	$6,106	1.0%	Defined
RBC Capital Markets, LLC	8,710	$85,096	14.4%	Defined
RBC Dominion Securities Inc.	51,095	$499,198	84.6%	Defined

Bank of New York Mellon Corp

$559,447

0.25%

57,262

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	16,437	$160,589	28.7%	Defined
The Bank of New York Mellon	32,505	$317,573	56.8%	Defined
Newton Investment Management North America, LLC	8,318	$81,266	14.5%	Defined
Held directly	2	$19	0.0%	Defined

Susquehanna Portfolio Strategies, LLC

$532,904

0.24%

54,545

XTX Topco Ltd

$520,467

0.23%

53,272

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	53,272	$520,467	100.0%	Defined

CITADEL ADVISORS LLC

$509,994

0.23%

52,200

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	52,200	$509,994	100.0%	Defined

CITADEL ADVISORS LLC

$508,714

0.23%

52,069

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	52,069	$508,714	100.0%	Defined

BANK OF AMERICA CORP /DE/

$487,756

0.22%

49,924

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	37,822	$369,520	75.8%	Defined
BOFA SECURITIES, INC.	12,102	$118,236	24.2%	Defined

Birchview Capital, LP

$419,641

0.19%

42,952

CITIGROUP INC

$370,448

0.17%

37,917

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	37,917	$370,448	100.0%	Defined

Nuveen, LLC

$369,969

0.17%

37,868

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	11,192	$109,345	29.6%	Defined
TEACHERS ADVISORS, LLC joint	26,676	$260,624	70.4%	Defined

MILLENNIUM MANAGEMENT LLC

$351,720

0.16%

36,000

Engineers Gate Manager LP

$331,847

0.15%

33,966

NOMURA ASSET MANAGEMENT INTERNATIONAL INC.

$325,663

0.15%

33,333

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NOMURA HOLDINGS INC joint	33,333	$325,663	100.0%	Defined

JANE STREET GROUP, LLC

$324,100

0.15%

33,173

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	33,173	$324,100	100.0%	Defined

TORONTO DOMINION BANK

$302,186

0.14%

30,930

SILVERBACK ASSET MANAGEMENT LLC

$293,100

0.13%

30,000

Baird Financial Group, Inc.

$291,058

0.13%

29,791

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Robert W. Baird & Co. Inc	29,791	$291,058	100.0%	Defined

JANE STREET GROUP, LLC

$286,261

0.13%

29,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	29,300	$286,261	100.0%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$265,988

0.12%

27,225

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	27,225	$265,988	100.0%	Defined

ExodusPoint Capital Management, LP

$259,706

0.12%

26,582

China Universal Asset Management Co., Ltd.

$244,250

0.11%

25,000

SIMPLEX TRADING, LLC

$235,320

0.11%

24,086

JANE STREET GROUP, LLC

$232,526

0.10%

23,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	23,800	$232,526	100.0%	Defined

RHUMBLINE ADVISERS

$229,272

0.10%

23,467

SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC

$227,299

0.10%

23,265

Velan Capital Investment Management LP

$195,400

0.09%

20,000

DEUTSCHE BANK AG\

$189,782

0.09%

19,425

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investments UK Ltd	19,425	$189,782	100.0%	Defined

WELLS FARGO & COMPANY/MN

$165,142

0.07%

16,903

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	16,903	$165,142	100.0%	Defined

SEI INVESTMENTS CO

$147,360

0.07%

15,083

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI INVESTMENTS MANAGEMENT CORP	2	$19	0.0%	Sole
SEI TRUST CO	15,081	$147,341	100.0%	Sole

HSBC HOLDINGS PLC

$134,337

0.06%

13,750

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
HSBC BANK PLC	13,750	$134,337	100.0%	Defined

CITADEL ADVISORS LLC

$133,849

0.06%

13,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	13,700	$133,849	100.0%	Defined

Headlands Technologies LLC

$118,344

0.05%

12,113

MetLife Investment Management, LLC

$117,406

0.05%

12,017

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	12,017	$117,406	100.0%	Defined

Virtu Financial LLC

$104,812

0.05%

10,728

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Virtu Americas LLC	10,728	$104,812	100.0%	Defined

Y-Intercept (Hong Kong) Ltd

$101,363

0.05%

10,375

Quadrature Capital Ltd

$100,591

0.05%

10,296

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	10,296	$100,591	100.0%	Other

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$89,600

0.04%

9,171

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	9,171	$89,600	100.0%	Defined

FMR LLC

$87,304

0.04%

8,936

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	8,936	$87,304	100.0%	Defined

Vanguard Global Advisers, LLC

$80,182

0.04%

8,207

Police & Firemen's Retirement System of New Jersey

$57,388

0.03%

5,874

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	5,874	$57,388	100.0%	Defined

TD Waterhouse Canada Inc.

$55,757

0.02%

5,707

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
TORONTO DOMINION BANK	5,707	$55,757	100.0%	Defined

NEW YORK STATE COMMON RETIREMENT FUND

$54,712

0.02%

5,600

Legal & General Group Plc

$18,904

0.01%

1,935

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Legal & General Investment Management America Inc	1,935	$18,904	100.0%	Defined

Ameritas Investment Partners, Inc.

$17,664

0.01%

1,808

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
EATON VANCE MANAGEMENT	1,808	$17,664	100.0%	Other

Russell Investments Group, Ltd.

$15,553

0.01%

1,592

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	1,592	$15,553	100.0%	Defined

Tower Research Capital LLC (TRC)

$12,300

0.01%

1,259

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Latour Trading LLC (Latour)	1,259	$12,300	100.0%	Defined

OSAIC HOLDINGS, INC.

$3,927

0.00%

402

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
OSAIC WEALTH, INC.	320	$3,126	79.6%	Defined
Osaic Advisory Services, LLC	82	$801	20.4%	Defined

Sterling Capital Management LLC

$3,439

0.00%

352

Key facts CIK 1503802 CUSIP 48576U205 13F (30d) 69 filings 69 filers Visit website Investor relations