KPTI · Karyopharm Therapeutics Inc. · Holdings
Substantial doubt about the company's ability to continue as a going concern.
“Based on our current business plan and current capital resources, combined with the uncertainty regarding the availability of additional funding or other strategic alternatives and considering our debt service obligations and financial covenant to maintain minimum liquidity, we have concluded that there is substantial doubt regarding our ability to continue as a going concern within one year after the date the accompanying condensed consolidated financial statements are issued.”View the 10-Q filed Aug 13, 2026
Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.
Institutional Ownership Trend
Holder Concentration
Across 100 13F filersWho Holds KPTI
Last 8 quarters through Sep 30, 2026 (filing window open)Each kind of 13F filer's share of the common shares 13F filers report. Holder type comes from regulatory records, never the filer's name; style, turnover and horizon are measured from each filer's own 13F book. The quarter selector does not change this card.
Jun 30, 2026, the newest closed quarter: 96 filers, like-for-like change +19.8%; actively managed books +3.9%; index-like books +120.1%.
| Holder type | Share | Filers | Change |
|---|---|---|---|
| Registered adviser | 53.6% | 39 | -4.2% |
| Exempt adviser | 5.4% | 4 | +232.8% |
| Adviser | 4.3% | 3 | -41.6% |
| Bank | 6.9% | 11 | +251.3% |
| Benefit plan | 0.0% | 1 | -98.6% |
| Non-US | 1.0% | 3 | +137337.1% |
| Holding company | 14.5% | 6 | +153.3% |
| Broker-dealer | 0.0% | 0 | -100.0% |
| Insurer | 0.0% | 0 | — |
| Unknown | 14.3% | 29 | +44.6% |
| Style | Share | Filers | Change |
|---|---|---|---|
| Index-like | 25.1% | 16 | +120.1% |
| Systematic-like | 6.5% | 9 | -13.2% |
| Concentrated | 29.0% | 15 | +17.0% |
| Diversified active | 39.4% | 56 | -1.1% |
| Not measured | 0.0% | 0 | — |
| Unknown | 0.0% | 0 | — |
| Turnover | Share | Filers | Change |
|---|---|---|---|
| Low turnover | 43.8% | 44 | +110.3% |
| Medium turnover | 26.5% | 20 | -27.0% |
| High turnover | 20.4% | 25 | -8.6% |
| Unknown | 9.3% | 7 | +127.9% |
| Not measured | 0.0% | 0 | — |
| Holding horizon | Share | Filers | Change |
|---|---|---|---|
| Short horizon | 17.1% | 18 | +85.0% |
| Medium horizon | 31.8% | 20 | -9.7% |
| Long horizon | 43.9% | 51 | +38.5% |
| Unknown | 7.3% | 7 | -1.4% |
| Not measured | 0.0% | 0 | — |
| 13F book size | Share | Filers | Change |
|---|---|---|---|
| Under $1B | 21.1% | 14 | +69.0% |
| $1B to $10B | 16.5% | 25 | -31.4% |
| $10B to $100B | 21.0% | 20 | -7.6% |
| $100B or more | 41.4% | 37 | +70.8% |
| Not measured | 0.0% | 0 | — |
| Client base | Share | Filers | Change |
|---|---|---|---|
| Individuals and high net worth | 0.0% | 6 | -56.4% |
| Pooled investment vehicles | 43.6% | 20 | -11.2% |
| Registered funds and BDCs | 8.4% | 6 | +71.4% |
| Insurance companies | 0.1% | 2 | new |
| Governments and sovereign funds | 1.0% | 2 | -17.9% |
| Corporations | 0.1% | 1 | -53.8% |
| Other investment advisers | 0.0% | 0 | — |
| Diversified | 0.4% | 2 | -2.9% |
| Unknown | 46.4% | 57 | +68.2% |
| Private funds | Share | Filers | Change |
|---|---|---|---|
| Hedge funds | 30.7% | 22 | -21.6% |
| Private equity funds | 0.2% | 2 | +113.4% |
| Venture capital funds | 16.2% | 3 | +22.0% |
| Other private funds | 3.8% | 4 | +868.0% |
| Mixed private funds | 0.0% | 0 | — |
| No private funds | 8.0% | 12 | +75.4% |
| Real estate funds | 0.0% | 0 | — |
| Private funds, type not stated | 0.0% | 0 | — |
| Unknown | 41.1% | 53 | +58.0% |
| Location | Share | Filers | Change |
|---|---|---|---|
| United States | 93.5% | 77 | +19.2% |
| Outside the US | 6.5% | 19 | +29.3% |
The Sep 30, 2026 filing window is still open, so its bar carries the Jun 30, 2026 positions of filers that have not filed yet.
How the mix is measured
Shares are 13F common shares restated to today's split basis; options and principal amounts are left out. The change compares only filers with a 13F in both quarters and keeps each filer in its bucket of the later quarter on both sides; a filer that continues under a new CIK is compared through its successor. Holder type comes from each filer's current regulatory profile; client base and private funds come from the Form ADV roster current at each quarter end (rosters from December 2019, so an earlier quarter reads Unknown). Style, turnover, horizon and book size are measured from each filer's 13F book in the newest measured quarter, and Not measured means none was. Actively managed books are those measured systematic-like, concentrated or diversified active.
Conviction and Crowding
96 13F filers, quarter ended Jun 30, 2026Measured across every 13F filer's common-share book once the quarter's filing window closed. Crowding counts filers with high turnover or that advise private funds on Form ADV.
Managers in the top fifth by current three-year FundScore alpha were net buyers of $0 (0 buying, 0 selling).
Estimated Holder Cost Basis
Quarter ended Jun 30, 2026, on that quarter's share basisEstimated, never filed: each 13F buy is costed at its quarter's average traded price and each sale keeps the average cost, so this is what holders paid on average if they traded evenly through each quarter.
Estimated cost covers 68.8% of the 13F shares; positions already held when a filer's 13F history starts, or bought in a quarter without a trusted average price, have no estimate.
Shared Holders
Companies KPTI's active holders also own, quarter ended Jun 30, 2026| # | Company | Shared holders |
|---|---|---|
| 1 | EQ Equillium, Inc. | 4 |
| 2 | SGP SpyGlass Pharma, Inc. | 3 |
| 3 | QNRX Quoin Pharmaceuticals Ltd. | 3 |
| 4 | MGNX Macrogenics Inc | 3 |
| 5 | VIR Vir Biotechnology, Inc. | 5 |
| 6 | SLDB Solid Biosciences Inc. | 5 |
| 7 | JBIO Jade Biosciences, Inc. | 5 |
| 8 | SVRA Savara Inc | 6 |
| 9 | QTTB Q32 Bio Inc. | 4 |
| 10 | EVMN Evommune, Inc. | 4 |
Shareholder Targets
13F filers that own its peers but not KPTI, quarter ended Jun 30, 2026Found through its holder-overlap peers: EQ, SGP, QNRX, MGNX, VIR, SLDB, JBIO, SVRA, QTTB, EVMN, IVVD, AVTX, CRVS, SEPN, OVID, URGN, PTGX, LONA, LENZ, TARA. 611 filers in all.
| # | Filer | In peers | Largest peers |
|---|---|---|---|
| 1 | RTW INVESTMENTS, LP Registered adviser, Diversified active | $886,369,860 6 held | PTGX, URGN, SLDB |
| 2 | FARALLON CAPITAL MANAGEMENT LLC Registered adviser, Diversified active | $824,411,937 2 held | PTGX, AVTX |
| 3 | Jupiter Topco LLC Unknown, Diversified active | $625,433,479 13 held | PTGX, JBIO, OVID |
| 4 | WELLINGTON MANAGEMENT GROUP LLP Holding company, Diversified active | $486,772,914 9 held | PTGX, CRVS, SVRA |
| 5 | PERCEPTIVE ADVISORS LLC Registered adviser, Diversified active | $316,430,835 6 held | PTGX, SLDB, CRVS |
| 6 | JOHNSON & JOHNSON Unknown, Concentrated | $300,220,852 1 held | PTGX |
| 7 | Woodline Partners LP Registered adviser, Systematic-like | $249,120,572 11 held | PTGX, SVRA, URGN |
| 8 | Driehaus Capital Management LLC Registered adviser, Diversified active | $242,266,893 3 held | SEPN, PTGX, IVVD |
| 9 | ADAR1 Capital Management, LLC Registered adviser, Diversified active | $242,021,584 13 held | PTGX, SEPN, VIR |
| 10 | ORBIMED ADVISORS LLC Registered adviser, Diversified active | $226,702,546 8 held | CRVS, QTTB, URGN |
Fund Ownership of KPTI by Fund Type
Registered funds' Form N-PORT reports for the quarter ended Jun 30, 2026Index funds and index ETFs hold 9.25% of shares outstanding.
| Fund type | Of shares outstanding | Shares |
|---|---|---|
| Index funds | 1.53% | 347,569 |
| Index ETFs | 7.72% | 1,750,407 |
| Active ETFs | 0.01% | 2,676 |
| Active funds | 2.70% | 613,437 |
| Unclassified | 0.00% | 0 |
| All registered funds | 11.97% | 2,714,089 |
How fund types are measured
Each fund series counts once, with its latest Form N-PORT report dated inside the quarter; only long share positions count, restated to today's split basis. The fund type is the series' latest Form N-CEN answer on or before the quarter end (the index-fund box and the exchange-traded flag), never its name. Unclassified funds have no usable N-CEN; unit investment trusts are among them, so index ownership is a floor. Funds sit inside their advisers' 13F reports, so these shares overlap the 13F figures and are never added to them.
| Holder | Value (USD) | % of 13F | Shares | Type | Filed | Open |
|---|---|---|---|---|---|---|
| Large RA CAPITAL MANAGEMENT, L.P. Registered adviser | $18,732,548 | 8.40% | 1,917,354 | Shares | 2026-08-14 | |
| Large ADAGE CAPITAL PARTNERS GP, L.L.C. Registered adviser | $14,863,315 | 6.67% | 1,521,322 | Shares | 2026-08-14 | |
| Small ACORN CAPITAL ADVISORS, LLC | $14,831,964 | 6.65% | 1,518,113 | Shares | 2026-08-14 | |
| Mega GOLDMAN SACHS GROUP INC Holding company | $13,918,908 | 6.24% | 1,424,658 | Shares | 2026-08-14 | |
| Mega BlackRock, Inc. Holding company | $13,861,664 | 6.22% | 1,418,799 | Shares | 2026-08-07 | |
| Mega VANGUARD CAPITAL MANAGEMENT LLC Registered adviser | $9,369,224 | 4.20% | 958,979 | Shares | 2026-08-13 | |
| Small Catalio Capital Management, LP Registered adviser | $9,192,153 | 4.12% | 940,855 | Shares | 2026-08-14 | |
| Small Avidity Partners Management LP Registered adviser | $9,032,237 | 4.05% | 924,487 | Shares | 2026-08-14 | |
| Mega T. Rowe Price Investment Management, Inc. Adviser | $7,682,238 | 3.45% | 786,309 | Shares | 2026-08-14 | |
| Mega TWO SIGMA INVESTMENTS, LP Registered adviser | $6,792,729 | 3.05% | 695,264 | Shares | 2026-08-14 | |
| Small Kalehua Capital Management LLC Exempt adviser | $6,698,741 | 3.00% | 685,644 | Shares | 2026-08-19 | |
| Mid NEA Management Company, LLC Registered adviser | $5,635,140 | 2.53% | 576,780 | Shares | 2026-08-14 | |
| Mega GEODE CAPITAL MANAGEMENT, LLC Registered adviser | $5,190,126 | 2.33% | 531,231 | Shares | 2026-08-12 | |
| Mid Ghisallo Capital Management LLC Registered adviser | $4,885,000 | 2.19% | 500,000 | Shares | 2026-08-14 | |
| Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP | $4,736,496 | 2.12% | 484,800 | Call | 2026-08-14 | |
| Mid Soleus Capital Management, L.P. | $4,298,800 | 1.93% | 440,000 | Shares | 2026-08-11 | |
| Mega UBS Group AG Bank | $3,454,134 | 1.55% | 353,545 | Shares | 2026-08-13 | |
| Mega STATE STREET CORP Bank | $3,184,932 | 1.43% | 325,991 | Shares | 2026-09-22 | |
| Mid Affinity Asset Advisors, LLC Registered adviser | $3,053,125 | 1.37% | 312,500 | Shares | 2026-08-13 | |
| Large Brevan Howard Capital Management LP Exempt adviser | $3,026,912 | 1.36% | 309,817 | Shares | 2026-08-14 | |
| Mega MILLENNIUM MANAGEMENT LLC Registered adviser | $2,986,454 | 1.34% | 305,676 | Shares | 2026-08-14 | |
| Mid Boxer Capital Management, LLC Registered adviser | $2,955,776 | 1.33% | 302,536 | Shares | 2026-08-14 | |
| Mid Davidson Kempner Capital Management LP Registered adviser | $2,931,000 | 1.31% | 300,000 | Shares | 2026-08-14 | |
| Large ACADIAN ASSET MANAGEMENT LLC | $2,921,200 | 1.31% | 298,997 | Shares | 2026-08-13 | |
| Small SILVERARC CAPITAL MANAGEMENT, LLC Registered adviser | $2,906,184 | 1.30% | 297,460 | Shares | 2026-08-13 | |
| Large Caption Management, LLC Registered adviser | $2,791,289 | 1.25% | 285,700 | Call | 2026-08-14 | |
| Mid Eversept Partners, LP Registered adviser | $2,698,219 | 1.21% | 276,174 | Shares | 2026-08-14 | |
| Small Tetragon Partners GP Ltd | $2,445,431 | 1.10% | 250,300 | Call | 2026-08-13 | |
| Mega JPMORGAN CHASE & CO Bank | $2,028,338 | 0.91% | 207,609 | Shares | 2026-08-12 | |
| Mega MORGAN STANLEY Holding company | $1,978,480 | 0.89% | 202,506 | Shares | 2026-08-13 | |
| Large Trexquant Investment LP Registered adviser | $1,840,355 | 0.83% | 188,368 | Shares | 2026-08-14 | |
| Mega BNP PARIBAS ARBITRAGE, SA Non-US | $1,837,131 | 0.82% | 188,038 | Shares | 2026-08-13 | |
| Mega BARCLAYS PLC Bank | $1,620,881 | 0.73% | 165,904 | Shares | 2026-08-14 | |
| Mega NORTHERN TRUST CORP Bank | $1,563,258 | 0.70% | 160,006 | Shares | 2026-08-13 | |
| Mega VANGUARD FIDUCIARY TRUST CO | $1,420,567 | 0.64% | 145,401 | Shares | 2026-08-13 | |
| Mega VANGUARD PORTFOLIO MANAGEMENT LLC Registered adviser | $1,317,171 | 0.59% | 134,818 | Shares | 2026-08-13 | |
| Mega MARSHALL WACE, LLP Exempt adviser | $1,254,965 | 0.56% | 128,451 | Shares | 2026-08-13 | |
| Large RENAISSANCE TECHNOLOGIES LLC Registered adviser | $1,057,250 | 0.47% | 108,214 | Shares | 2026-08-13 | |
| Small DLD Asset Management, LP Registered adviser | $991,655 | 0.44% | 101,500 | Put | 2026-08-13 | |
| Mid C WorldWide Group Holding A/S | $977,000 | 0.44% | 100,000 | Shares | 2026-08-04 | |
| Small SILVERBACK ASSET MANAGEMENT LLC Registered adviser | $977,000 | 0.44% | 100,000 | Call | 2026-08-13 | |
| Large Jump Financial, LLC | $918,380 | 0.41% | 94,000 | Shares | 2026-08-13 | |
| Large Caption Management, LLC Registered adviser | $903,725 | 0.41% | 92,500 | Put | 2026-08-14 | |
| Mega Invesco Ltd. Adviser | $882,268 | 0.40% | 90,304 | Shares | 2026-08-14 | |
| Small DLD Asset Management, LP Registered adviser | $782,577 | 0.35% | 80,100 | Call | 2026-08-13 | |
| Large Connor, Clark & Lunn Investment Management Ltd. Registered adviser | $746,398 | 0.33% | 76,397 | Shares | 2026-08-13 | |
| Mid BRIDGEWAY CAPITAL MANAGEMENT, LLC Registered adviser | $702,199 | 0.31% | 71,873 | Shares | 2026-08-14 | |
| Mid J. Goldman & Co LP Registered adviser | $660,452 | 0.30% | 67,600 | Put | 2026-08-14 | |
| Mid J. Goldman & Co LP Registered adviser | $659,475 | 0.30% | 67,500 | Shares | 2026-08-14 | |
| Large Squarepoint Ops LLC Registered adviser | $623,335 | 0.28% | 63,801 | Shares | 2026-08-14 | |
| Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC Registered adviser | $605,183 | 0.27% | 61,943 | Shares | 2026-08-14 | |
| Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP | $594,993 | 0.27% | 60,900 | Put | 2026-08-14 | |
| Mega ROYAL BANK OF CANADA Bank | $590,400 | 0.26% | 60,430 | Shares | 2026-08-14 | |
| Mega Bank of New York Mellon Corp Bank | $559,447 | 0.25% | 57,262 | Shares | 2026-08-06 | |
| Mid Susquehanna Portfolio Strategies, LLC | $532,904 | 0.24% | 54,545 | Shares | 2026-08-14 | |
| Mid XTX Topco Ltd | $520,467 | 0.23% | 53,272 | Shares | 2026-08-14 | |
| Mega CITADEL ADVISORS LLC Registered adviser | $509,994 | 0.23% | 52,200 | Call | 2026-09-02 | |
| Mega CITADEL ADVISORS LLC Registered adviser | $508,714 | 0.23% | 52,069 | Shares | 2026-09-02 | |
| Mega BANK OF AMERICA CORP /DE/ Bank | $487,756 | 0.22% | 49,924 | Shares | 2026-08-14 | |
| Small Birchview Capital, LP | $419,641 | 0.19% | 42,952 | Shares | 2026-08-14 | |
| Mega CITIGROUP INC Bank | $370,448 | 0.17% | 37,917 | Shares | 2026-08-03 | |
| Mega Nuveen, LLC | $369,969 | 0.17% | 37,868 | Shares | 2026-08-11 | |
| Mega MILLENNIUM MANAGEMENT LLC Registered adviser | $351,720 | 0.16% | 36,000 | Put | 2026-08-14 | |
| Mid Engineers Gate Manager LP | $331,847 | 0.15% | 33,966 | Shares | 2026-08-14 | |
| Large NOMURA ASSET MANAGEMENT INTERNATIONAL INC. Adviser | $325,663 | 0.15% | 33,333 | Shares | 2026-08-14 | |
| Mega JANE STREET GROUP, LLC | $324,100 | 0.15% | 33,173 | Shares | 2026-08-14 | |
| Large TORONTO DOMINION BANK Bank | $302,186 | 0.14% | 30,930 | Shares | 2026-08-14 | |
| Small SILVERBACK ASSET MANAGEMENT LLC Registered adviser | $293,100 | 0.13% | 30,000 | Shares | 2026-08-13 | |
| Large Baird Financial Group, Inc. | $291,058 | 0.13% | 29,791 | Shares | 2026-08-12 | |
| Mega JANE STREET GROUP, LLC | $286,261 | 0.13% | 29,300 | Call | 2026-08-14 | |
| Mega PRICE T ROWE ASSOCIATES INC /MD/ Registered adviser | $265,988 | 0.12% | 27,225 | Shares | 2026-08-14 | |
| Large ExodusPoint Capital Management, LP Registered adviser | $259,706 | 0.12% | 26,582 | Shares | 2026-08-14 | |
| Mid China Universal Asset Management Co., Ltd. | $244,250 | 0.11% | 25,000 | Shares | 2026-07-24 | |
| Mid SIMPLEX TRADING, LLC | $235,320 | 0.11% | 24,086 | Shares | 2026-08-12 | |
| Mega JANE STREET GROUP, LLC | $232,526 | 0.10% | 23,800 | Put | 2026-08-14 | |
| Mega RHUMBLINE ADVISERS Registered adviser | $229,272 | 0.10% | 23,467 | Shares | 2026-08-12 | |
| Mid SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $227,299 | 0.10% | 23,265 | Shares | 2026-08-14 | |
| Small Velan Capital Investment Management LP Registered adviser | $195,400 | 0.09% | 20,000 | Shares | 2026-08-14 | |
| Mega DEUTSCHE BANK AG\ Non-US | $189,782 | 0.09% | 19,425 | Shares | 2026-08-07 | |
| Mega WELLS FARGO & COMPANY/MN Bank | $165,142 | 0.07% | 16,903 | Shares | 2026-08-14 | |
| Mega SEI INVESTMENTS CO Holding company | $147,360 | 0.07% | 15,083 | Shares | 2026-08-14 | |
| Mega HSBC HOLDINGS PLC | $134,337 | 0.06% | 13,750 | Shares | 2026-08-14 | |
| Mega CITADEL ADVISORS LLC Registered adviser | $133,849 | 0.06% | 13,700 | Put | 2026-09-02 | |
| Small Headlands Technologies LLC | $118,344 | 0.05% | 12,113 | Shares | 2026-08-13 | |
| Large MetLife Investment Management, LLC Registered adviser | $117,406 | 0.05% | 12,017 | Shares | 2026-08-14 | |
| Mid Virtu Financial LLC | $104,812 | 0.05% | 10,728 | Shares | 2026-08-13 | |
| Large Quadrature Capital Ltd | $100,591 | 0.05% | 10,296 | Shares | 2026-08-07 | |
| Large MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $89,600 | 0.04% | 9,171 | Shares | 2026-08-14 | |
| Mega FMR LLC Holding company | $87,304 | 0.04% | 8,936 | Shares | 2026-08-13 | |
| Mega Vanguard Global Advisers, LLC Registered adviser | $80,182 | 0.04% | 8,207 | Shares | 2026-08-13 | |
| Large Police & Firemen's Retirement System of New Jersey | $57,388 | 0.03% | 5,874 | Shares | 2026-07-23 | |
| Large NEW YORK STATE COMMON RETIREMENT FUND | $54,712 | 0.02% | 5,600 | Shares | 2026-07-29 | |
| Mega Legal & General Group Plc | $18,904 | 0.01% | 1,935 | Shares | 2026-08-14 | |
| Mid Ameritas Investment Partners, Inc. Registered adviser | $17,664 | 0.01% | 1,808 | Shares | 2026-08-13 | |
| Mega Russell Investments Group, Ltd. | $15,553 | 0.01% | 1,592 | Shares | 2026-08-06 | |
| Mid Tower Research Capital LLC (TRC) | $12,300 | 0.01% | 1,259 | Shares | 2026-08-11 | |
| Large TD Waterhouse Canada Inc. | $6,962 | 0.00% | 5,707 | Shares | 2026-10-16 | |
| Large OSAIC HOLDINGS, INC. Holding company | $3,927 | 0.00% | 402 | Shares | 2026-08-14 | |
| Mid HARBOUR INVESTMENTS, INC. Registered adviser | $2,784 | 0.00% | 285 | Shares | 2026-08-12 | |
| Mega CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM Benefit plan | $2,676 | 0.00% | 274 | Shares | 2026-08-24 |
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