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KPTI · Karyopharm Therapeutics Inc.

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$6.80 -0.29 (-4.09%)
Going-concern doubt — flagged May 14, 2026

Substantial doubt about the company's ability to continue as a going concern.

“Based on our current business plan and current capital resources, combined with the uncertainty regarding the availability of additional funding or other strategic alternatives and considering our debt service obligations and financial covenant to maintain minimum liquidity, we have concluded that there is substantial doubt regarding our ability to continue as a going concern within one year after the date the accompanying condensed consolidated financial statements are issued.”
View the 10-Q filed May 14, 2026
Market Cap
$160.68M
Shares
22.66M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

The Jun 30, 2026 filing window is still open — showing the latest known positions. Funds that have not filed yet carry their prior-quarter positions; a fund that filed without this stock counts as sold out.
Holders: 86
Total Value: $141,041,857
Total Shares: 25,285,856
Showing 1–100 of 103 holdings by value · page 1 of 2

Institutional Ownership Trend

6 quarters

Holder Concentration

Across 83 13F filers
Top Holder
10.2%
Mar 2025 → Mar 2026 · range 10.2% – 20.3%
of institutional value
Top 5
38.7%
Mar 2025 → Mar 2026 · range 38.7% – 59.1%
of institutional value
Top 10
58.9%
Mar 2025 → Mar 2026 · range 58.9% – 78.3%
of institutional value
HHI
454
Mar 2025 → Mar 2026 · range 454 – 919
Broadly held
Showing 100 of 103
All Common Calls Puts
Export CSV
Holder Value (USD) % of 13F Shares Open
Mid Commodore Capital LP $10,861,500 7.70% 1,950,000
Mid RA CAPITAL MANAGEMENT, L.P. $10,679,661 7.57% 1,917,354
Large ADAGE CAPITAL PARTNERS GP, L.L.C. $10,061,213 7.13% 1,806,322
Mega T. Rowe Price Investment Management, Inc. $8,589,441 6.09% 1,542,090
Large Caption Management, LLC $6,054,033 4.29% 1,086,900
Mega GOLDMAN SACHS GROUP INC $5,278,015 3.74% 947,579
Mid Ikarian Capital, LLC $5,124,400 3.63% 920,000
Mid Ikarian Capital, LLC $5,124,400 3.63% 920,000
Small Catalio Capital Management, LP $5,000,239 3.55% 897,709
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $4,818,050 3.42% 865,000
Small Squadron Capital Management LLC $4,177,500 2.96% 750,000
Mega VANGUARD CAPITAL MANAGEMENT LLC $4,120,379 2.92% 739,745
Mid Ikarian Capital, LLC $4,085,232 2.90% 733,435
Mid Affinity Asset Advisors, LLC $2,785,000 1.97% 500,000
Mega JANE STREET GROUP, LLC $2,636,838 1.87% 473,400
Small Avidity Partners Management LP $2,583,037 1.83% 463,741
Mid Soleus Capital Management, L.P. $2,450,800 1.74% 440,000
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $2,372,263 1.68% 425,900
Mega MILLENNIUM MANAGEMENT LLC $2,342,580 1.66% 420,571
Small Boxer Capital Management, LLC $1,685,125 1.19% 302,536
Mid Davidson Kempner Capital Management LP $1,671,000 1.18% 300,000
Small ACORN CAPITAL ADVISORS, LLC $1,603,190 1.14% 287,826
Mid Eversept Partners, LP $1,538,289 1.09% 276,174
Mid BOOTHBAY FUND MANAGEMENT, LLC $1,494,431 1.06% 268,300
Mid BOOTHBAY FUND MANAGEMENT, LLC $1,494,431 1.06% 268,300
Mid Jump Financial, LLC $1,460,152 1.04% 262,146
Mega CITADEL ADVISORS LLC $1,438,174 1.02% 258,200
Large Trexquant Investment LP $1,436,519 1.02% 257,903
Small Ally Bridge Group (NY) LLC $1,392,500 0.99% 250,000
Mega CITADEL ADVISORS LLC $1,388,601 0.98% 249,300
Large ACADIAN ASSET MANAGEMENT LLC $1,386,690 0.98% 248,957
Mega BlackRock, Inc. $1,364,085 0.97% 244,899
Small DIADEMA PARTNERS LP $1,344,041 0.95% 241,300
Mid BOOTHBAY FUND MANAGEMENT, LLC $1,190,921 0.84% 213,810
Mid Brevan Howard Capital Management LP $1,182,884 0.84% 212,367
Mega GEODE CAPITAL MANAGEMENT, LLC $1,148,160 0.81% 206,133
Mid ADAR1 Capital Management, LLC $1,142,964 0.81% 205,200
Mega UBS Group AG $1,080,674 0.77% 194,017
Mid GROUP ONE TRADING LLC $1,066,805 0.76% 191,527
Mid XTX Topco Ltd $915,947 0.65% 164,443
Mega TWO SIGMA INVESTMENTS, LP $842,362 0.60% 151,232
Mid ADAR1 Capital Management, LLC $761,619 0.54% 136,736
Large MARSHALL WACE, LLP $715,471 0.51% 128,451
Mega VANGUARD FIDUCIARY TRUST CO Bank $640,182 0.45% 114,934
Mid Engineers Gate Manager LP $626,246 0.44% 112,432
Mega JANE STREET GROUP, LLC $589,868 0.42% 105,901
Large RENAISSANCE TECHNOLOGIES LLC $587,155 0.42% 105,414
Mid C WorldWide Group Holding A/S $557,000 0.39% 100,000
Small SILVERBACK ASSET MANAGEMENT LLC $557,000 0.39% 100,000
Large Balyasny Asset Management L.P. $557,000 0.39% 100,000
Large Caption Management, LLC $529,150 0.38% 95,000
Mega MILLENNIUM MANAGEMENT LLC $506,870 0.36% 91,000
Mega STATE STREET CORP $449,732 0.32% 80,742
Large Connor, Clark & Lunn Investment Management Ltd. $440,481 0.31% 79,081
Mid BRIDGEWAY CAPITAL MANAGEMENT, LLC $400,332 0.28% 71,873
Large Balyasny Asset Management L.P. $394,066 0.28% 70,748
Small SILVERBACK ASSET MANAGEMENT LLC $362,050 0.26% 65,000
Mega ROYAL BANK OF CANADA Bank $336,420 0.24% 60,399
Small Tetragon Partners GP Ltd $295,120 0.21% 52,984
Small Tetragon Partners GP Ltd $278,500 0.20% 50,000
Small DAFNA Capital Management LLC $255,106 0.18% 45,800
Mid China Universal Asset Management Co., Ltd. $244,250 0.17% 25,000
Mega NORTHERN TRUST CORP Bank $214,755 0.15% 38,556
Mid Zimmer Partners, LP $208,875 0.15% 37,500
Large Centiva Capital, LP $168,269 0.12% 30,210
Large Point72 Asset Management, L.P. $167,100 0.12% 30,000
Large Baird Financial Group, Inc. $165,935 0.12% 29,791
Mid Susquehanna Portfolio Strategies, LLC $139,366 0.10% 25,021
Mega SUSQUEHANNA INTERNATIONAL GROUP, LLP $134,448 0.10% 24,138
Mid Eversept Partners, LP $132,566 0.09% 23,800
Mega BANK OF AMERICA CORP /DE/ Bank $108,459 0.08% 19,472
Large OMERS ADMINISTRATION Corp $108,058 0.08% 19,400
Mega MORGAN STANLEY $103,433 0.07% 18,570
Mid Y-Intercept (Hong Kong) Ltd $101,363 0.07% 10,375
Mega Invesco Ltd. $93,230 0.07% 16,738
Small Velan Capital Investment Management LP $83,550 0.06% 15,000
Mega JANE STREET GROUP, LLC $80,208 0.06% 14,400
Mega CHARLES SCHWAB INVESTMENT MANAGEMENT INC $74,799 0.05% 13,429
Mega HSBC HOLDINGS PLC $64,027 0.05% 11,495
Mega Bank of New York Mellon Corp Bank $63,492 0.05% 11,399
Mega PRICE T ROWE ASSOCIATES INC /MD/ $60,635 0.04% 10,886
Large Police & Firemen's Retirement System of New Jersey Pension $57,388 0.04% 5,874
Large TD Waterhouse Canada Inc. $55,757 0.04% 5,707
Mega Vanguard Global Advisers, LLC $45,712 0.03% 8,207
Mega BARCLAYS PLC $41,351 0.03% 7,424
Mega CITIGROUP INC $27,521 0.02% 4,941
Large Centiva Capital, LP $20,052 0.01% 3,600
Large Rockefeller Capital Management L.P. $4,082 0.00% 733
Mega FMR LLC $3,704 0.00% 665
Mid Sterling Capital Management LLC $3,439 0.00% 352
Small Persistent Asset Partners Ltd $3,397 0.00% 610
Mega JPMORGAN CHASE & CO $2,623 0.00% 471
Large OSAIC HOLDINGS, INC. $2,238 0.00% 402
Mid HARBOUR INVESTMENTS, INC. $1,587 0.00% 285
Small Quent Capital, LLC $1,308 0.00% 235
Micro MB, LEVIS & ASSOCIATES, LLC $977 0.00% 100
Mid SBI Securities Co., Ltd. Broker-Dealer $654 0.00% 67
Small Activest Wealth Management $644 0.00% 66
Mega BNP PARIBAS ARBITRAGE, SA $467 0.00% 84
Mid Allworth Financial LP $144 0.00% 26
Key facts CIK 1503802 CUSIP 48576U205 13F (30d) 10 filings 10 filers Visit website Investor relations

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