Affinity Asset Advisors, LLC

CIK

1773195

Location

NEW YORK, NY

Portfolio Value

Mid $1,882,251,340

Diversification

Diversified

Filing Date

Global Rank

#1,244 / 8,603 ▲ 284 · as of Mar 2026

Top Industry

Biotechnology 91.0%

3Y Alpha vs SPY

+13.3%

Period ended 3 months ago

Filed May 14, 2026 · 56d

22 quarters · since Dec 2020

Clone Performance

Jul 2023–Jul 2026 · vs SPY

Hypothetical growth of cloning every reported 13F position and rebalancing on each filing, indexed to the same start.

Cloned portfolio

+141.4%

SPY

+76.0%

Annualised alpha

+13.4%

Max drawdown

−46.0%

Estimate. 13F holdings are quarter-lagged and long-only, so the clone rebalances about 45 days after each period end — when the filing becomes public — and excludes options and short positions. Past performance does not predict future results.

Portfolio Concentration

97 positions · as of Mar 31, 2026 · Δ vs Dec 31, 2025

Top Position

6.9%

−0.0 pts

Top 5

26.6%

+0.6 pts

Top 10

42.5%

−0.9 pts

HHI

270

Diversified−12

Portfolio Trend

22 quarters · across all stocks

Sector Breakdown

As of Mar 31, 2026

Sector	% Portfolio	Value	Positions
Healthcare	92.4%	$1,739,483,340	95
Unclassified	6.9%	$130,068,000	1
Financial Services	0.7%	$12,700,000	1

Last Quarter's Activity

Export CSV

Mar 31, 2026 vs Dec 31, 2025

Added To

Positions the filer increased

25 positions

Ticker	Company	Δ Shares	Shares	Value
OVID	Ovid Therapeutics Inc.	+3,486,318	10,636,318	$23,612,625
CATX	Perspective Therapeutics, Inc.	+2,864,582	3,164,582	$13,196,306
LXEO	Lexeo Therapeutics, Inc.	+1,850,211	5,050,211	$28,988,211
ERAS	Erasca, Inc.	+1,450,000	5,350,000	$86,563,000
EPRX	Eupraxia Pharmaceuticals Inc.	+1,289,005	1,589,005	$11,504,396
ROIV	Roivant Sciences Ltd.	+1,100,000	2,800,000	$77,560,000
IBIO	iBio, Inc.	+1,050,000	3,107,200	$5,903,680
CMPS	COMPASS Pathways plc	+908,483	1,108,483	$6,129,910
CNTA	Centessa Pharmaceuticals plc	+799,448	1,400,000	$55,608,000
ZURA	Zura Bio Ltd	+750,632	2,564,303	$15,257,602
ANAB	Anaptysbio, Inc	+495,308	940,000	$34,754,902
AVR	Anteris Technologies Global Corp.	+425,713	912,397	$5,063,803
XENE	Xenon Pharmaceuticals Inc.	+425,000	1,675,000	$97,401,250
COGT	Cogent Biosciences, Inc.	+400,000	750,000	$28,867,500
ALKS	Alkermes plc.	+350,000	1,350,000	$47,736,000
STRO	Sutro Biopharma, Inc.	+321,137	1,069,519	$26,641,718
AVTX	Avalo Therapeutics, Inc.	+289,786	1,340,840	$20,018,741
DNTH	Dianthus Therapeutics, Inc. /DE/	+285,000	400,000	$33,568,000
CLDX	Celldex Therapeutics, Inc.	+150,000	500,000	$15,860,000
ARWR	Arrowhead Pharmaceuticals, Inc.	+130,000	200,000	$12,540,000
RVMD	Revolution Medicines, Inc.	+100,000	200,000	$19,450,000
ASND	Ascendis Pharma A/S	+65,000	95,000	$21,729,350
APGE	Apogee Therapeutics, Inc.	+50,000	1,284,926	$108,152,221
BLTE	Belite Bio, Inc	+45,000	65,000	$10,363,600
INSM	INSMED Inc	+30,000	480,000	$78,489,600
No positions match the current search.

Trimmed

Positions the filer reduced

25 positions

Ticker	Company	Δ Shares	Shares	Value
TSHA	Taysha Gene Therapies, Inc.	−2,300,000	1,000,000	$4,470,000
WVE	Wave Life Sciences Ltd.	−1,298,273	1,401,727	$10,162,520
CGEM	Cullinan Therapeutics, Inc.	−1,150,846	781,260	$11,101,704
RZLT	Rezolute, Inc.	−803,503	1,547,641	$4,720,305
CLYM	Climb Bio, Inc.	−600,000	700,000	$4,795,000
QURE	uniQure N.V.	−550,000	300,000	$4,905,000
KPTI	Karyopharm Therapeutics Inc.	−389,575	500,000	$2,785,000
ORKA	Oruka Therapeutics, Inc.	−302,669	499,673	$24,508,960
SVRA	Savara Inc	−285,000	2,512,153	$13,716,355
SGMT	Sagimet Biosciences Inc.	−280,225	868,020	$4,535,404
OBIO	Orchestra BioMed Holdings, Inc.	−170,254	402,550	$1,710,837
BBIO	BridgeBio Pharma, Inc.	−170,000	150,000	$11,139,000
ACLX	Arcellx, Inc.	−160,961	362,764	$41,652,562
SYRE	Spyre Therapeutics, Inc.	−153,457	1,279,134	$64,519,518
TRVI	Trevi Therapeutics, Inc.	−150,000	2,000,172	$23,862,051
MBX	MBX Biosciences, Inc.	−100,000	150,000	$4,477,500
IMVT	Immunovant, Inc.	−100,000	100,000	$2,484,000
ESTA	Establishment Labs Holdings Inc.	−100,000	100,000	$5,678,000
ABVX	Abivax S.A.	−100,000	405,000	$45,096,750
CYTK	Cytokinetics Inc	−99,517	700,483	$46,168,834
JBIO	Jade Biosciences, Inc.	−75,000	639,956	$8,991,381
ENGN	enGene Therapeutics Inc.	−33,000	610,370	$4,156,619
NUVL	Nuvalent, Inc.	−22,633	300,000	$30,735,000
PRAX	Praxis Precision Medicines, Inc.	−15,000	170,000	$54,772,300
NXTC	NextCure, Inc.	−5,468	241,826	$2,582,701
No positions match the current search.

New Positions

Positions the filer opened this quarter

25 positions

Ticker	Company	Shares	Value
SPY	Spdr S&P 500 ETF Trust	200,000	$130,068,000
MRNA	Moderna, Inc.	800,000	$40,640,000
ELVN	Enliven Therapeutics, Inc.	586,904	$23,006,636
BMY	Bristol Myers Squibb Co	300,000	$18,195,000
HLXC	Helix Acquisition Corp. III	1,250,000	$12,700,000
DMRA	Damora Therapeutics, Inc.	450,000	$11,655,000
ANRO	Alto Neuroscience, Inc.	500,000	$11,240,000
TYRA	Tyra Biosciences, Inc.	257,512	$9,862,709
IBRX	ImmunityBio, Inc.	1,250,000	$9,587,500
KRRO	Korro Bio, Inc.	706,904	$8,002,153
CRSP	CRISPR Therapeutics AG	150,000	$7,135,500
SGP	SpyGlass Pharma, Inc.	250,000	$6,477,500
NVO	Novo Nordisk A S	175,000	$6,431,250
MANE	Veradermics, Inc	70,000	$4,420,500
GENB	Generate Biomedicines, Inc.	350,000	$4,375,000
CGON	CG Oncology, Inc.	60,000	$4,060,800
RLAY	Relay Therapeutics, Inc.	400,000	$3,980,000
CELC	Celcuity Inc.	30,000	$3,424,200
DTIL	Precision Biosciences Inc	597,946	$3,288,703
SLGL	Sol-Gel Technologies Ltd.	35,000	$2,772,700
EQ	Equillium, Inc.	1,226,310	$2,452,620
SABS	SAB Biotherapeutics, Inc.	575,000	$2,202,250
CORT	Corcept Therapeutics Inc	50,000	$2,015,500
ANL	Adlai Nortye Ltd.	164,748	$1,140,056
ALEC	Alector, Inc.	500,000	$1,075,000
No positions match the current search.

Sold Out

Positions the filer fully exited

8 positions

Ticker	Company	Shares	Value
AMGN	Amgen Inc	145,000	$47,459,950
TNGX	Tango Therapeutics, Inc.	1,000,000	$8,860,000
RCUS	Arcus Biosciences, Inc.	300,000	$7,149,000
SMMT	Summit Therapeutics Inc.	350,000	$6,121,500
ABUS	Arbutus Biopharma Corp	521,900	$2,510,339
GERN	Geron Corp	1,500,000	$1,980,000
RARE	Ultragenyx Pharmaceutical Inc.	75,000	$1,725,000
PCSC	Perceptive Capital Solutions Corp	50,000	$651,500
No positions match the current search.

Portfolio Positions

Compact Export CSV View 13F filing

97 positions · $1,882,251,340 total · as of Mar 31, 2026

All sectors Financial Services Healthcare

Showing 1–50 of 97 positions by value · page 1 of 2

Ticker	Company	Type	Shares	Δ Shares	Value (USD)	% Δ Value	% of Portfolio
SPY	Spdr S&P 500 ETF Trust	NEW	200,000	NEW	$130,068,000	NEW	6.91%
APGE	Apogee Therapeutics, Inc. Healthcare	Added	1,284,926	+50,000	$108,152,221	+16.0%	5.75%
XENE	Xenon Pharmaceuticals Inc. Healthcare	Added	1,675,000	+425,000	$97,401,250	+73.9%	5.17%
ERAS	Erasca, Inc. Healthcare	Added	5,350,000	+1,450,000	$86,563,000	+496.7%	4.60%
INSM	INSMED Inc Healthcare	Added	480,000	+30,000	$78,489,600	+0.2%	4.17%
ROIV	Roivant Sciences Ltd. Healthcare	Added	2,800,000	+1,100,000	$77,560,000	+110.2%	4.12%
SYRE	Spyre Therapeutics, Inc. Healthcare	Reduced	1,279,134	-153,457	$64,519,518	+37.5%	3.43%
CNTA	Centessa Pharmaceuticals plc Healthcare	Added	1,400,000	+799,448	$55,608,000	+270.2%	2.95%
PRAX	Praxis Precision Medicines, Inc. Healthcare	Reduced	170,000	-15,000	$54,772,300	+0.5%	2.91%
ALKS	Alkermes plc. Healthcare	Added	1,350,000	+350,000	$47,736,000	+70.6%	2.54%
CYTK	Cytokinetics Inc Healthcare	Reduced	700,483	-99,517	$46,168,834	−9.2%	2.45%
ABVX	Abivax S.A. Healthcare	Reduced	405,000	-100,000	$45,096,750	−33.8%	2.40%
TEVA	Teva Pharmaceutical Industries Ltd Healthcare	Held	1,400,000	0	$42,168,000	−3.5%	2.24%
ACLX	Arcellx, Inc. Healthcare	Reduced	362,764	-160,961	$41,652,562	+22.0%	2.21%
MRNA	Moderna, Inc. Healthcare	NEW	800,000	NEW	$40,640,000	NEW	2.16%
ANAB	Anaptysbio, Inc Healthcare	Added	940,000	+495,308	$34,754,902	+141.8%	1.85%
DNTH	Dianthus Therapeutics, Inc. /DE/ Healthcare	Added	400,000	+285,000	$33,568,000	+608.3%	1.78%
NUVL	Nuvalent, Inc. Healthcare	Reduced	300,000	-22,633	$30,735,000	−5.3%	1.63%
TERN	Terns Pharmaceuticals, Inc. Healthcare	Added	562,631	+12,631	$29,661,906	+33.5%	1.58%
LXEO	Lexeo Therapeutics, Inc. Healthcare	Added	5,050,211	+1,850,211	$28,988,211	−8.8%	1.54%
COGT	Cogent Biosciences, Inc. Healthcare	Added	750,000	+400,000	$28,867,500	+132.2%	1.53%
MDGL	Madrigal Pharmaceuticals, Inc. Healthcare	Added	55,000	+23,869	$28,790,850	+58.8%	1.53%
STRO	Sutro Biopharma, Inc. Healthcare	Added	1,069,519	+321,137	$26,641,718	+207.7%	1.42%
FBRX	Forte Biosciences, Inc. Healthcare	Held	1,011,890	0	$26,207,951	−5.0%	1.39%
ORKA	Oruka Therapeutics, Inc. Healthcare	Reduced	499,673	-302,669	$24,508,960	+0.8%	1.30%
TRVI	Trevi Therapeutics, Inc. Healthcare	Reduced	2,000,172	-150,000	$23,862,051	−11.4%	1.27%
OVID	Ovid Therapeutics Inc. Healthcare	Added	10,636,318	+3,486,318	$23,612,625	+102.6%	1.25%
ELVN	Enliven Therapeutics, Inc. Healthcare	NEW	586,904	NEW	$23,006,636	NEW	1.22%
ASND	Ascendis Pharma A/S Healthcare	Added	95,000	+65,000	$21,729,350	+239.7%	1.15%
MLYS	Mineralys Therapeutics, Inc. Healthcare	Added	750,000	+20,000	$20,317,500	−23.3%	1.08%
AVTX	Avalo Therapeutics, Inc. Healthcare	Added	1,340,840	+289,786	$20,018,741	+4.9%	1.06%
RVMD	Revolution Medicines, Inc. Healthcare	Added	200,000	+100,000	$19,450,000	+144.2%	1.03%
BMY	Bristol Myers Squibb Co Healthcare	NEW	300,000	NEW	$18,195,000	NEW	0.97%
PTGX	Protagonist Therapeutics, Inc Healthcare	Held	172,125	0	$18,141,975	+20.7%	0.96%
CLDX	Celldex Therapeutics, Inc. Healthcare	Added	500,000	+150,000	$15,860,000	+66.8%	0.84%
ZURA	Zura Bio Ltd Healthcare	Added	2,564,303	+750,632	$15,257,602	+60.5%	0.81%
NRIX	Nurix Therapeutics, Inc. Healthcare	Held	967,620	0	$14,998,110	−18.3%	0.80%
SVRA	Savara Inc Healthcare	Reduced	2,512,153	-285,000	$13,716,355	−18.7%	0.73%
CATX	Perspective Therapeutics, Inc. Healthcare	Added	3,164,582	+2,864,582	$13,196,306	+1499.6%	0.70%
HLXC	Helix Acquisition Corp. III Financial Services	NEW	1,250,000	NEW	$12,700,000	NEW	0.67%
ARWR	Arrowhead Pharmaceuticals, Inc. Healthcare	Added	200,000	+130,000	$12,540,000	+169.8%	0.67%
DMRA	Damora Therapeutics, Inc. Healthcare	NEW	450,000	NEW	$11,655,000	NEW	0.62%
EPRX	Eupraxia Pharmaceuticals Inc. Healthcare	Added	1,589,005	+1,289,005	$11,504,396	+407.9%	0.61%
ANRO	Alto Neuroscience, Inc. Healthcare	NEW	500,000	NEW	$11,240,000	NEW	0.60%
BBIO	BridgeBio Pharma, Inc. Healthcare	Reduced	150,000	-170,000	$11,139,000	−54.5%	0.59%
CGEM	Cullinan Therapeutics, Inc. Healthcare	Reduced	781,260	-1,150,846	$11,101,704	−44.5%	0.59%
BLTE	Belite Bio, Inc Healthcare	Added	65,000	+45,000	$10,363,600	+223.9%	0.55%
WVE	Wave Life Sciences Ltd. Healthcare	Reduced	1,401,727	-1,298,273	$10,162,520	−77.9%	0.54%
VERA	Vera Therapeutics, Inc. Healthcare	Held	250,000	0	$10,057,500	−20.6%	0.53%
TYRA	Tyra Biosciences, Inc. Healthcare	NEW	257,512	NEW	$9,862,709	NEW	0.52%