LXEO · Lexeo Therapeutics, Inc. · Holdings

$4.25 -0.11 (-2.52%) At close · Sep 11

Russell 2000 member Rebalance outlook locked

Market Cap

$348.70M

82.05M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Quarter:

Holders: 143

Total Value: $411,074,346

Total Shares: 88,308,150

Showing 1–100 of 143 holdings by value · page 1 of 2

Institutional Ownership Trend

11 quarters

Holder Concentration

Across 143 13F filers · Δ vs Mar 31, 2026

Top Holder

7.2%

−0.5 pts

Top 5

31.4%

−1.5 pts

Top 10

54.9%

−2.9 pts

HHI

402

Broadly held−16

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +3

Institutional value: -10.4%

Shares held: +10.4%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mid SUVRETTA CAPITAL MANAGEMENT, LLC	+5,134,200	6,384,200
Mega MILLENNIUM MANAGEMENT LLC	+1,220,842	2,833,622
Mega Qube Research & Technologies Ltd	+910,707	1,376,222
Large Balyasny Asset Management L.P.	+823,157	2,412,742
Mega STATE STREET CORP	+786,515	4,354,757

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Mid Paradigm Biocapital Advisors LP	−2,008,752	4,175,382
Large Avoro Capital Advisors LLC	−385,811	1,489,189
Large Woodline Partners LP	−250,000	2,500,532
Mid Vestal Point Capital, LP	−155,000	4,320,000
Large ExodusPoint Capital Management, LP	−84,292	27,880

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Mega Jupiter Topco LLC	3,954,691	$18,409,085
Large Trexquant Investment LP	314,891	$1,465,817
Mid Hennion & Walsh Asset Management, Inc.	265,697	$1,236,819
Large RENAISSANCE TECHNOLOGIES LLC	250,365	$1,165,449
Small Palumbo Wealth Management LLC	114,743	$534,128

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mega JANUS HENDERSON GROUP PLC	4,976,429	$28,564,702
Large Point72 Asset Management, L.P.	1,680,449	$9,645,777
Mid Octagon Capital Advisors LP	1,100,000	$6,314,000
Mega TWO SIGMA INVESTMENTS, LP	181,676	$1,042,820
Mid Y-Intercept (Hong Kong) Ltd	142,571	$818,357

Filter: New 27 Increased 60 Reduced 40 Sold out 24 Unchanged 16

Showing 100 of 143

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

SUVRETTA CAPITAL MANAGEMENT, LLC

$29,718,451

7.23%

6,384,200

Affinity Asset Advisors, LLC

$27,034,429

6.58%

5,807,611

BlackRock, Inc.

$26,717,158

6.50%

5,739,455

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	26,699	$124,283	0.5%	Sole
BlackRock Investment Management, LLC	220,479	$1,026,329	3.8%	Sole
BLACKROCK ADVISORS LLC	157,555	$733,418	2.7%	Sole
BlackRock Fund Advisors	3,305,471	$15,386,967	57.6%	Sole
BlackRock Institutional Trust Company, N.A.	1,901,155	$8,849,876	33.1%	Sole
BlackRock Asset Management Ireland Ltd	57,858	$269,328	1.0%	Sole
Aperio Group, LLC	70,238	$326,957	1.2%	Sole

RA CAPITAL MANAGEMENT, L.P.

$23,275,000

5.66%

5,000,000

Frazier Life Sciences Management, L.P.

$22,459,094

5.46%

4,824,725

STATE STREET CORP

$20,271,393

4.93%

4,354,757

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	4,354,757	$20,271,393	100.0%	Defined

Vestal Point Capital, LP

$20,109,600

4.89%

4,320,000

Paradigm Biocapital Advisors LP

$19,436,403

4.73%

4,175,382

Jupiter Topco LLC

$18,409,085

4.48%

3,954,691

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JANUS HENDERSON INVESTORS UK Ltd	12,546	$58,401	0.3%	Defined
JANUS HENDERSON INVESTORS US LLC	3,942,145	$18,350,684	99.7%	Defined

ORBIMED ADVISORS LLC

$18,377,241

4.47%

3,947,850

CITADEL ADVISORS LLC

$18,147,842

4.41%

3,898,570

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	210,603	$980,356	5.4%	Defined
Held directly	3,687,967	$17,167,486	94.6%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$14,551,031

3.54%

3,125,893

MILLENNIUM MANAGEMENT LLC

$13,190,510

3.21%

2,833,622

Woodline Partners LP

$11,639,976

2.83%

2,500,532

Balyasny Asset Management L.P.

$11,231,314

2.73%

2,412,742

GOLDMAN SACHS GROUP INC

$10,006,442

2.43%

2,149,612

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	1,738,802	$8,094,123	80.9%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	396,925	$1,847,685	18.5%	Defined
Goldman Sachs Trust Company, N.A. joint	13,885	$64,634	0.6%	Other

683 Capital Management, LLC

$8,728,125

2.12%

1,875,000

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
683 Capital Partners, LP	1,875,000	$8,728,125	100.0%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$8,136,748

1.98%

1,747,959

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	238,061	$1,108,173	13.6%	Defined
Held directly	1,509,898	$7,028,575	86.4%	Defined

ADAR1 Capital Management, LLC

$7,289,497

1.77%

1,565,950

Avoro Capital Advisors LLC

$6,932,174

1.69%

1,489,189

Qube Research & Technologies Ltd

$6,406,313

1.56%

1,376,222

Nantahala Capital Management, LLC

$6,051,500

1.47%

1,300,000

DIMENSIONAL FUND ADVISORS LP

$5,991,843

1.46%

1,287,185

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	5,792	$26,961	0.4%	Defined
DFA Australia Ltd.	22,116	$102,949	1.7%	Defined
Dimensional Ireland Ltd	56,406	$262,569	4.4%	Defined
Held directly	1,202,871	$5,599,364	93.4%	Sole

Spruce Street Capital LP

$4,322,600

1.05%

928,593

Blackstone Inc.

$4,212,584

1.02%

904,959

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Blackstone Alternative Asset Management L.P.	904,959	$4,212,584	100.0%	Other

NORTHERN TRUST CORP

$4,037,703

0.98%

867,391

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	856,269	$3,985,931	98.7%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	11,122	$51,772	1.3%	Other

Aberdeen Group plc

$3,142,553

0.76%

675,092

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
abrdn Inc.	675,092	$3,142,553	100.0%	Defined

VANGUARD PORTFOLIO MANAGEMENT LLC

$2,857,360

0.70%

613,826

Ikarian Capital, LLC

$2,388,066

0.58%

513,011

BANK OF AMERICA CORP /DE/

$2,282,490

0.56%

490,331

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	445,990	$2,076,083	91.0%	Defined
BOFA SECURITIES, INC.	44,341	$206,407	9.0%	Defined

VANGUARD FIDUCIARY TRUST CO

$2,004,889

0.49%

430,696

MORGAN STANLEY

$1,839,198

0.45%

395,102

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	5	$23	0.0%	Defined
MORGAN STANLEY & CO. LLC	263,411	$1,226,178	66.7%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	11,552	$53,774	2.9%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	120,134	$559,223	30.4%	Defined

BNP PARIBAS ARBITRAGE, SA

$1,807,992

0.44%

388,398

DAFNA Capital Management LLC

$1,755,209

0.43%

377,059

UBS Group AG

$1,648,074

0.40%

354,044

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS AG	353,767	$1,646,785	99.9%	Defined
UBS Securities LLC	277	$1,289	0.1%	Defined

Trexquant Investment LP

$1,465,817

0.36%

314,891

Squarepoint Ops LLC

$1,372,172

0.33%

294,774

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	294,774	$1,372,172	100.0%	Defined

Hennion & Walsh Asset Management, Inc.

$1,236,819

0.30%

265,697

AQR CAPITAL MANAGEMENT LLC

$1,194,754

0.29%

256,661

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Arax Advisory Partners	2,687	$12,507	1.0%	Other
HALBERT HARGROVE GLOBAL ADVISORS, LLC	2,154	$10,026	0.8%	Other
Stokes Family Office, LLC	1,187	$5,525	0.5%	Other
Held directly	250,633	$1,166,696	97.7%	Defined

RENAISSANCE TECHNOLOGIES LLC

$1,165,449

0.28%

250,365

WELLINGTON MANAGEMENT GROUP LLP

$942,091

0.23%

202,383

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	66,096	$307,676	32.7%	Defined
Wellington Trust Company, NA joint	127,369	$592,902	62.9%	Defined
Wellington Management Australia Pty Ltd	8,918	$41,513	4.4%	Defined

Nuveen, LLC

$932,940

0.23%

200,417

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	1,867	$8,690	0.9%	Defined
TEACHERS ADVISORS, LLC joint	198,550	$924,250	99.1%	Defined

Bank of New York Mellon Corp

$855,974

0.21%

183,883

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	65,104	$303,059	35.4%	Defined
The Bank of New York Mellon	117,964	$549,122	64.2%	Defined
BNY Mellon, NA joint	815	$3,793	0.4%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$803,494

0.20%

172,609

Susquehanna Portfolio Strategies, LLC

$749,743

0.18%

161,062

Privium Fund Management B.V.

$721,525

0.18%

155,000

XTX Topco Ltd

$677,563

0.16%

145,556

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	145,556	$677,563	100.0%	Defined

FMR LLC

$657,034

0.16%

141,146

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	141,146	$657,034	100.0%	Defined

BOOTHBAY FUND MANAGEMENT, LLC

$634,834

0.15%

136,377

Burkehill Global Management, LP

$581,875

0.14%

125,000

RAYMOND JAMES FINANCIAL INC

$546,440

0.13%

117,388

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
RAYMOND JAMES & ASSOCIATES	2,977	$13,857	2.5%	Defined
Raymond James Financial Services Advisors, Inc.	114,411	$532,583	97.5%	Defined

Palumbo Wealth Management LLC

$534,128

0.13%

114,743

Fisher Asset Management, LLC

$532,168

0.13%

114,322

EntryPoint Capital, LLC

$482,481

0.12%

103,648

JPMORGAN CHASE & CO

$448,229

0.11%

96,290

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	34,242	$159,396	35.6%	Defined
J.P. Morgan Investment Management Inc.	57,205	$266,289	59.4%	Defined
J.P. Morgan Securities plc	4,843	$22,544	5.0%	Defined

CITIGROUP INC

$436,373

0.11%

93,743

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	93,743	$436,373	100.0%	Defined

DEUTSCHE BANK AG\

$383,073

0.09%

82,293

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS INVESTMENT MANAGEMENT AMERICAS, INC	13,128	$61,110	16.0%	Defined
DWS Investments UK Ltd	69,165	$321,963	84.0%	Defined

RHUMBLINE ADVISERS

$371,510

0.09%

79,809

ALLIANCEBERNSTEIN L.P.

$362,438

0.09%

77,860

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	77,860	$362,438	100.0%	Defined

Invesco Ltd.

$354,796

0.09%

76,219

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	9,050	$42,126	11.9%	Defined
Invesco Trust Co joint	26,319	$122,514	34.5%	Defined
Invesco Capital Management LLC	40,850	$190,156	53.6%	Defined

Virtus Investment Advisers, LLC

$348,538

0.08%

74,874

Walleye Capital LLC

$343,855

0.08%

73,868

Creative Planning

$338,069

0.08%

72,625

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
CREATIVE PLANNING TRUST Co LLC	72	$335	0.1%	Defined
Held directly	72,553	$337,734	99.9%	Sole

Rafferty Asset Management, LLC

$314,375

0.08%

67,535

WELLS FARGO & COMPANY/MN

$276,344

0.07%

59,365

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	59,365	$276,344	100.0%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$270,893

0.07%

58,194

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	58,194	$270,893	100.0%	Defined

JANE STREET GROUP, LLC

$241,129

0.06%

51,800

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	51,800	$241,129	100.0%	Defined

Mitsubishi UFJ Asset Management Co., Ltd.

$232,694

0.06%

49,988

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MITSUBISHI UFJ FINANCIAL GROUP INC	49,988	$232,694	100.0%	Defined

STATE OF WISCONSIN INVESTMENT BOARD

$224,948

0.05%

48,324

LOS ANGELES CAPITAL MANAGEMENT LLC

$224,259

0.05%

48,176

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$188,457

0.05%

40,485

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	32,640	$151,939	80.6%	Defined
Global X Management (AUS) Ltd joint	7,845	$36,518	19.4%	Defined

MetLife Investment Management, LLC

$184,095

0.04%

39,548

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	39,548	$184,095	100.0%	Defined

PROFUND ADVISORS LLC

$159,745

0.04%

34,317

Russell Investments Group, Ltd.

$154,884

0.04%

33,273

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Russell Investment Management, LLC	33,273	$154,884	100.0%	Defined

Dynamic Technology Lab Private Ltd

$151,990

0.04%

32,651

Verdad Advisers, LP

$142,401

0.03%

30,591

ExodusPoint Capital Management, LP

$129,781

0.03%

27,880

Police & Firemen's Retirement System of New Jersey

$118,865

0.03%

25,535

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	25,535	$118,865	100.0%	Defined

Quantinno Capital Management LP

$113,083

0.03%

24,293

Vanguard Global Advisers, LLC

$108,857

0.03%

23,385

PRELUDE CAPITAL MANAGEMENT, LLC

$104,737

0.03%

22,500

Soltis Investment Advisors LLC

$93,174

0.02%

20,016

NEW YORK STATE COMMON RETIREMENT FUND

$92,573

0.02%

19,887

D. E. Shaw & Co., Inc.

$92,476

0.02%

19,866

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	19,866	$92,476	100.0%	Defined

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$92,192

0.02%

19,805

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	19,805	$92,192	100.0%	Defined

Vanguard Personalized Indexing Management, LLC

$90,614

0.02%

19,466

AMERICAN CENTURY COMPANIES INC

$87,770

0.02%

18,855

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	18,855	$87,770	100.0%	Defined

CANADA PENSION PLAN INVESTMENT BOARD

$86,117

0.02%

18,500

INTECH INVESTMENT MANAGEMENT LLC

$82,938

0.02%

17,817

CAXTON CORP

$78,958

0.02%

16,962

Jain Global LLC

$77,203

0.02%

16,585

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$76,342

0.02%

16,400

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	16,400	$76,342	100.0%	Other

BARCLAYS PLC

$75,675

0.02%

16,257

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	12,725	$59,234	78.3%	Defined
BARCLAYS CAPITAL INC.	3,532	$16,441	21.7%	Defined

Spark Investment Management LLC

$69,825

0.02%

15,000

VOYA INVESTMENT MANAGEMENT LLC

$66,240

0.02%

14,230

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Voya Investment Management Co. LLC joint	14,230	$66,240	100.0%	Defined

Cerity Partners LLC

$64,755

0.02%

13,911

WEALTH ENHANCEMENT ADVISORY SERVICES, LLC

$59,327

0.01%

12,745

China Universal Asset Management Co., Ltd.

$58,173

0.01%

12,497

ProShare Advisors LLC

$55,175

0.01%

11,853

PRUDENTIAL FINANCIAL INC

$53,928

0.01%

11,585

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	11,585	$53,928	100.0%	Defined

Key facts CIK 1907108 CUSIP 52886X107 13F (30d) 55 filings 55 filers Visit website Investor relations