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RA CAPITAL MANAGEMENT, L.P.

Registered adviser
Location
BOSTON, MA
Portfolio Value
Large $11,507,518,878
Diversification
Diversified
Filing Date
Global Rank
#494 / 8,825 ▲ 6
Top Industry
Biotechnology 97.6%
Period ended 4 months ago
Filed Aug 14, 2026 · 3mo
26 quarters · since Mar 2020

Regulatory profile

From Form ADV, the SEC filer profile, 13D/13G type codes and N-CEN, never from the name.

Holder type
Registered adviser
Form ADV roster, Nov 1, 2026
Form ADV adviser
CRD 160174
Roster of Nov 1, 2026
Regulatory AUM
$16,401,931,385
Main clients
Pooled investment vehicles (100% of AUM)
Private funds
6 funds · Venture capital funds
Focus by fund count, roster of Nov 1, 2026
$16,339,781,064 gross assets
LEI
549300ZV6X2KFAD7UG21
Private funds on Schedule D 7.B.(1)
As filed Mar 29, 2024; SEC's bulk Form ADV archive ends with 2024 filings.
$11,227,234,426 gross assets in 5 funds Hedge funds $9,377,168,016 (1) Venture capital funds $1,850,066,410 (4)
Form ADV history
Monthly rosters from Dec 2019; each row is a run with the same figures, newest first.
Rosters Regulatory AUM Main clients
Apr 2026 to Nov 2026 $16,401,931,385 Pooled investment vehicles (100%)
Dec 2025 to Mar 2026 $12,629,842,282 Pooled investment vehicles (99%)
Apr 2025 to Sep 2025 $12,629,842,282 Pooled investment vehicles (99%)
Apr 2024 to Mar 2025 $11,323,065,361 Pooled investment vehicles (99%)
Dec 2023 to Mar 2024 $9,650,336,033 Pooled investment vehicles (99%)
May 2023 to Nov 2023 $9,650,336,033 Pooled investment vehicles (99%)
6 earlier changes not shown.

Schedule 13D/13G stakes

Stakes of 5% or more disclosed on Schedule 13D or 13G, each on the filer's latest filing for the security. These are event-dated stakes, not the quarter-end 13F portfolio below.

Company Schedule Filed Shares % of class Status
ALEC Alector, Inc. 13G 9d 7,500,000 5.1% Current
CRBP Corbus Pharmaceuticals Holdings, Inc. 13G 35d 1,914,788 9.9% Current
SION Sionna Therapeutics, Inc. 13D/A not restated by this amendment, the earlier 13D's purpose stands 44d 6,476,193 14.3% Current
BETRF BetterLife Pharma Inc. 13G 43d 55,420,000 9% Current
TYRA Tyra Biosciences, Inc. 13D/A not restated by this amendment, the earlier 13D's purpose stands 48d 14,130,492 19.9% Current
JTTT JATT III Acquisition Corp 13G 2mo 450,000 5.1% Current
GHRS GH Research PLC 13G/A 3mo 4,897,182 7.1% Current
SEPN Septerna, Inc. 13D/A not restated by this amendment, the earlier 13D's purpose stands 3mo 5,525,324 11.8% Current
LTGO Latigo Biotherapeutics, Inc. 13G 3mo 5,295,690 8.4% Current
WVE Wave Life Sciences, Inc. 13D/A Strategic alternatives, Other 3mo 34,314,406 16.8% Current
SABS SAB Biotherapeutics, Inc. 13D/A not restated by this amendment, the earlier 13D's purpose stands 3mo 9,609,852 9.9% Current
TCGX TCGX Acquisition Corp. 13G 3mo 500,000 5.5% Current
OBX Obsidian Therapeutics, Inc. 13G 3mo 5,957,103 9.7% Current
INO Inovio Pharmaceuticals, Inc. 13G 3mo 10,666,523 9.9% Current
DBVT DBV Technologies S.A. 13G 3mo 18,288,220 5.8% Current
IKT Inhibikase Therapeutics, Inc. 13G/A 3mo 14,653,994 9.9% Current
CAPR Capricor Therapeutics, Inc. 13G 3mo 3,014,183 5.2% Current
SCTX Scribe Therapeutics, Inc. 13G 3mo 1,802,178 9.6% Current
ARTV Artiva Biotherapeutics, Inc. 13D/A not restated by this amendment, the earlier 13D's purpose stands 3mo 18,415,956 37.9% Current
FRNM Freenome, Inc. 13D/A Passive investment 4mo 15,367,270 14.3% Current
VOR Vor Biopharma Inc. 13D/A none of the classified purposes 4mo 12,937,855 19.9% Current
AGEN Agenus Inc 13G 4mo 4,344,772 9.9% Current
CLYM Climb Bio, Inc. 13D/A Control or board seats 4mo 23,249,186 33% Current
ACET Adicet Bio, Inc. 13G/A 3mo 935,486 9.9% Current
ACRS Aclaris Therapeutics, Inc. 13G/A 3mo 12,723,026 9.1% Current
AVTX Avalo Therapeutics, Inc. 13G/A 3mo 3,483,099 6.3% Current
BCRX Biocryst Pharmaceuticals Inc 13G/A 3mo 15,827,186 6.2% Current
CCCC C4 Therapeutics, Inc. 13G/A 3mo 11,383,696 9.9% Current
CRVO CervoMed Inc. 13G/A 3mo 1,266,143 8.6% Current
EWTX Edgewise Therapeutics, Inc. 13G/A 3mo 8,392,730 7.8% Current
GERN Geron Corp 13G/A 3mo 66,502,728 9.9% Current
KPTI Karyopharm Therapeutics Inc. 13G/A 3mo 2,302,504 9.9% Current
OVID Ovid Therapeutics Inc. 13G/A 3mo 19,549,271 9.9% Current
RANI Rani Therapeutics Holdings, Inc. 13G/A 3mo 11,530,414 9.9% Current
TSHA Taysha Gene Therapies, Inc. 13G/A 3mo 32,886,242 9.9% Current
SLDB Solid Biosciences Inc. 13D/A not restated by this amendment, the earlier 13D's purpose stands 4mo 12,036,126 11.9% Current
PBLS Parabilis Medicines, Inc. 13D Passive investment 5mo 28,933,371 23.8% Current
QTTB Q32 Bio Inc. 13G 5mo 2,332,457 9.8% Current
EDIT Editas Medicine, Inc. 13G 5mo 8,889,000 5.8% Current
SANA Sana Biotechnology, Inc. 13G 6mo 18,750,000 6.3% Current
COAG Hemab Therapeutics Holdings, Inc. 13G 6mo 7,729,773 16.6% Current
ALT Altimmune, Inc. 13G 6mo 13,000,000 6.5% Current
ACRV Acrivon Therapeutics, Inc. 13D/A not restated by this amendment, the earlier 13D's purpose stands 6mo 12,284,906 28.8% Current
PRLD Prelude Therapeutics Inc 13G 6mo 6,477,309 9.9% Current
JATT JATT II Acquisition Corp. 13G 6mo 500,000 6.4% Current
FDMT 4D Molecular Therapeutics, Inc. 13G/A 6mo 5,105,622 9.9% Current
IVVD Invivyd, Inc. 13G/A 6mo 21,342,442 7% Current
OKUR OnKure Therapeutics, Inc. 13G 7mo 4,038,715 9.9% Current
PALI Palisade Bio, Inc. 13G/A 6mo 17,620,479 9.9% Current
PCVX Vaxcyte, Inc. 13G/A 6mo 12,974,599 8.9% Current

Showing the 50 newest of 80 stakes. The REST API and the MCP server page through them all.

A 13D or 13G stays in force until its filer amends it and no amendment is due without a material change, so a stake with no filing in 24 months reads unconfirmed, never sold. An amendment reporting under 5% ends the filer's duty to amend, not necessarily the holding. Shares are restated onto today's split basis. Show 54 exited, below-5% or retired stakes

Portfolio style

Measured from the filed 13F common-share book for Jun 30, 2026, never from the firm's own description.

Style
Concentrated
The top 10 positions are 60.5% of the book (60%+)
Turnover
Medium turnover
36.1% over the last four quarters (30% to under 100%)
Horizon
Long horizon
Value-weighted holding period 14.7 quarters (12+), a floor since 32.7% of the book was already held when coverage starts

Closest benchmark: the Russell 2000 as of 2026-06-30, active share 97.5%; sector active share 90.7% against the combined 13F book's sector weights.

Over time 26 measured quarters

How the bands are measured

Style bands measure the filed 13F common-share book each closed quarter, tested in this order. Unknown: under $10,000,000 of valued equity or 5 stocks. Index-like (100+ stocks): active share of 20% or less against the closest benchmark, which is the S&P 500, S&P MidCap 400, S&P SmallCap 600, Russell 1000, Russell 2000, Nasdaq-100 or Dow Jones Industrial Average (weighted by an index-tracking fund's reported holdings or the index's constituents nearest the quarter end, over the names resolved to companies, and only when those are 90%+ of its weight) or every 13F filer's combined book, or index series holding 80%+ of the registered fund assets it advises (N-CEN) and equal to 50%+ of its book. Systematic-like: 500+ stocks, 100%+ annual turnover and a top 10 weight of 25% or less. Concentrated: a top 10 weight of 60%+ or 12 or fewer effective positions. Diversified active: none of these. Turnover is the smaller of buys and sells over average equity value, summed over four quarters: low under 30%, high 100%+. Horizon is the value-weighted number of quarters each position has been held: short under 4, long 12+.

Clone Performance

Build a hypothetical price-return history from this filer's public 13F holdings.

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Portfolio Concentration

84 tracked positions · as of Jun 30, 2026 · Δ vs Mar 31, 2026
Top Position
23.8%
−1.1 pts
Top 5
46.7%
−0.6 pts
Top 10
60.5%
−0.9 pts
HHI
784
Sep 2023 → Jun 2026 · range 616 – 1,184
Diversified−47

Portfolio Trend

26 quarters · across all stocks

Sector Breakdown

As of Jun 30, 2026
Sector % Portfolio Value
Healthcare 99.8% $11,484,728,878
Financial Services 0.2% $22,790,000

Last Quarter's Activity

Export CSV
Jun 30, 2026 vs Mar 31, 2026

Added To

Positions the filer increased
10 positions
Ticker Δ Shares Shares Value Open

Trimmed

Positions the filer reduced
10 positions
Ticker Δ Shares Shares Value Open
— −1,287,689 1,246,456 $153,937,316

New Positions

Positions the filer opened this quarter
16 positions
Ticker Shares Value Open

Sold Out

Positions the filer fully exited
17 positions
Ticker Shares Value Open

Portfolio Positions

Export CSV View 13F filing
84 tracked positions · $11,507,518,878 total · filing declares 85 positions · $11,507,522,068 · as of Jun 30, 2026
Showing 1–50 of 84 positions by value · page 1 of 2
Ticker Company Shares Value (USD) % of Portfolio History
1,246,456 $153,937,316 1.34%

Showing the top 50 of 84 positions. Create a free account to see every position, past quarters, search, filters and CSV export.

Covers the securities this platform tracks: U.S.-listed common stock and the put/call positions reported on it. A 13F can also report security types outside that coverage — preferred shares, bonds, warrants, untracked share classes — so the filing's own declared total can exceed the figures above. The source filing is linked at the top of this table.