CCCC · C4 Therapeutics, Inc. · Holdings

$2.99 +0.04 (+1.36%)

Russell 2000 member Rebalance outlook locked

Market Cap

$385.07M

123.03M

Volume · Oct 5 1.43M Avg daily vol (3M) 2.5M

Institutional ownership from SEC Form 13F filings. Investment managers with more than $100 million in U.S. equities must disclose their positions every quarter, within 45 days of quarter-end, so the holdings shown can lag the market by up to a quarter.

Use institutional holdings through the 13F API or MCP →

Some SEC filings for this period have not finished importing. Holder totals and changes may be incomplete; these filings remain queued for recovery.

Quarter:

Holders: 147

Total Value: $554,076,342

Total Shares: 118,645,916

Showing 1–100 of 155 holdings by value · page 1 of 2

Institutional Ownership Trend

23 quarters

Holder Concentration

Across 147 13F filers · Δ vs Mar 31, 2026

Top Holder

7.5%

−3.2 pts

Top 5

33.5%

−8.0 pts

Top 10

53.8%

−6.0 pts

HHI

384

Broadly held−114

Quarterly Activity

vs Mar 31, 2026

New

Increased

Decreased

Sold Out

Unchanged

Holder count: +24

Institutional value: +148.5%

Shares held: +40.0%

Top Buyers

vs Mar 31, 2026

Institution	Added	Now Holds
Mega BlackRock, Inc.	+5,848,192	7,896,718
Small Squadron Capital Management LLC	+5,350,000	7,600,000
Mega STATE STREET CORP	+1,732,648	2,115,621
Mega CITADEL ADVISORS LLC	+1,695,665	4,284,280
Mega GEODE CAPITAL MANAGEMENT, LLC	+1,571,120	2,522,163

Top Sellers

vs Mar 31, 2026

Institution	Sold	Now Holds
Large RENAISSANCE TECHNOLOGIES LLC	−1,271,987	1,189,828
Mega MILLENNIUM MANAGEMENT LLC	−1,177,956	215,386
Mega JANE STREET GROUP, LLC	−993,746	353,050
Mid Soleus Capital Management, L.P.	−425,961	3,377,981
Mega WELLS FARGO & COMPANY/MN	−415,210	452,701

Top New Positions

vs Mar 31, 2026

Institution	Acquired	Value (USD)
Small Ikarian Capital, LLC	2,433,000	$11,362,110
Large Candriam S.C.A.	1,796,937	$8,391,695
Small Patient Square Capital LP	1,608,815	$7,513,166
Small HighVista Strategies LLC	1,348,136	$6,295,795
Mid BOOTHBAY FUND MANAGEMENT, LLC	736,331	$3,438,665

Top Sold-Out Positions

vs Mar 31, 2026

Institution	Previously Held	Last Value (USD)
Mid ORBIMED ADVISORS LLC	856,353	$2,252,208
Mid 683 Capital Management, LLC	300,000	$789,000
Mid Hennion & Walsh Asset Management, Inc.	223,168	$586,931
Large HRT FINANCIAL LP	162,930	$428,505
Large Hudson Bay Capital Management LP	130,081	$342,113

Filter: New 51 Increased 54 Reduced 27 Sold out 27 Unchanged 15

Showing 100 of 155

All Common Calls Puts

Compact Export CSV

Holder

Value (USD)

% of 13F

MORGAN STANLEY

$41,410,467

7.47%

8,867,338

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MORGAN STANLEY & CO INTERNATIONAL PLC	8,172	$38,163	0.1%	Defined
MORGAN STANLEY & CO. LLC	134,047	$625,999	1.5%	Defined
MORGAN STANLEY CAPITAL SERVICES, LLC	8,718,000	$40,713,060	98.3%	Defined
MORGAN STANLEY SMITH BARNEY LLC	1,783	$8,326	0.0%	Defined
PARAMETRIC PORTFOLIO ASSOCIATES LLC	5,336	$24,919	0.1%	Defined

RA CAPITAL MANAGEMENT, L.P.

$37,360,000

6.74%

8,000,000

BlackRock, Inc.

$36,877,670

6.66%

7,896,718

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BLACKROCK FINANCIAL MANAGEMENT INC/DE	97,867	$457,038	1.2%	Sole
BlackRock Investment Management, LLC	303,884	$1,419,138	3.8%	Sole
BLACKROCK ADVISORS LLC	221,296	$1,033,452	2.8%	Sole
BlackRock Fund Advisors	4,616,692	$21,559,951	58.5%	Sole
BlackRock Institutional Trust Company, N.A.	2,565,590	$11,981,305	32.5%	Sole
BlackRock Asset Management Ireland Ltd	84,875	$396,366	1.1%	Sole
Aperio Group, LLC	6,514	$30,420	0.1%	Sole

Lynx1 Capital Management LP

$34,215,646

6.18%

7,326,691

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Lynx1 Capital Advisors LLC	7,326,691	$34,215,646	100.0%	Other

Squadron Capital Management LLC

$33,624,000

6.07%

7,200,000

Bain Capital Life Sciences Investors, LLC

$33,492,819

6.04%

7,171,910

JPMORGAN CHASE & CO

$22,170,467

4.00%

4,747,424

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
JPMorgan Chase Bank, N.A.	42,501	$198,478	0.9%	Defined
J.P. Morgan Securities LLC	4,697,395	$21,936,834	98.9%	Defined
J.P. Morgan Markets Ltd	7,528	$35,155	0.2%	Defined

VANGUARD CAPITAL MANAGEMENT LLC

$20,630,803

3.72%

4,417,731

CITADEL ADVISORS LLC

$19,555,998

3.53%

4,187,580

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	347,271	$1,621,755	8.3%	Defined
Held directly	3,840,309	$17,934,243	91.7%	Defined

GOLDMAN SACHS GROUP INC

$16,489,727

2.98%

3,530,991

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GOLDMAN SACHS & CO. LLC	3,189,940	$14,897,019	90.3%	Defined
GOLDMAN SACHS ASSET MANAGEMENT, L.P.	341,051	$1,592,708	9.7%	Defined

WASATCH ADVISORS LP

$16,450,747

2.97%

3,522,644

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	3,522,644	$16,450,747	100.0%	Sole

TWO SIGMA INVESTMENTS, LP

$16,203,531

2.92%

3,469,707

Soleus Capital Management, L.P.

$15,775,171

2.85%

3,377,981

SILVERARC CAPITAL MANAGEMENT, LLC

$14,159,720

2.56%

3,032,060

BANK OF AMERICA CORP /DE/

$12,405,195

2.24%

2,656,359

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BANK OF AMERICA NA	1,218,811	$5,691,847	45.9%	Defined
BOFA SECURITIES, INC.	1,165,169	$5,441,339	43.9%	Defined
MANAGED ACCOUNT ADVISORS LLC joint	272,379	$1,272,009	10.3%	Defined

GEODE CAPITAL MANAGEMENT, LLC

$11,778,500

2.13%

2,522,163

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
GEODE CAPITAL MANAGEMENT TRUST COMPANY, LLC	364,394	$1,701,719	14.4%	Defined
Held directly	2,157,769	$10,076,781	85.6%	Defined

Ikarian Capital, LLC

$11,362,110

2.05%

2,433,000

STATE STREET CORP

$9,879,950

1.78%

2,115,621

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
STATE STREET GLOBAL ADVISORS EUROPE LIMITED joint	2,115,621	$9,879,950	100.0%	Defined

ACADIAN ASSET MANAGEMENT LLC

$8,434,949

1.52%

1,806,199

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Acadian Inc	1,806,199	$8,434,949	100.0%	Defined

Candriam S.C.A.

$8,391,695

1.51%

1,796,937

D. E. Shaw & Co., Inc.

$8,130,418

1.47%

1,740,989

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
D. E. SHAW & CO, L.P.	1,740,989	$8,130,418	100.0%	Defined

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$8,089,420

1.46%

1,732,210

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	1,732,210	$8,089,420	100.0%	Other

Patient Square Capital LP

$7,513,166

1.36%

1,608,815

HighVista Strategies LLC

$6,295,795

1.14%

1,348,136

RENAISSANCE TECHNOLOGIES LLC

$5,556,496

1.00%

1,189,828

DIMENSIONAL FUND ADVISORS LP

$5,550,326

1.00%

1,188,507

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Dimensional Fund Advisors Ltd.	13,005	$60,733	1.1%	Defined
DFA Australia Ltd.	51,572	$240,841	4.3%	Defined
Dimensional Ireland Ltd	56,985	$266,119	4.8%	Defined
Held directly	1,066,945	$4,982,633	89.8%	Sole

NORTHERN TRUST CORP

$5,419,754

0.98%

1,160,547

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
NORTHERN TRUST CO joint	1,144,638	$5,345,459	98.6%	Defined
DWS INVESTMENT MANAGEMENT AMERICAS, INC joint	15,909	$74,295	1.4%	Other

CONGRESS ASSET MANAGEMENT CO

$4,686,050

0.85%

1,003,437

FMR LLC

$4,175,231

0.75%

894,054

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Fidelity Management & Research Co LLC	893,402	$4,172,187	99.9%	Defined
STRATEGIC ADVISERS LLC	652	$3,044	0.1%	Defined

UBS Group AG

$3,871,288

0.70%

828,970

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
UBS Financial Services Inc	29,293	$136,798	3.5%	Defined
UBS AG	770,241	$3,597,025	92.9%	Defined
UBS Switzerland AG	4,572	$21,351	0.6%	Defined
UBS Europe SE	8	$37	0.0%	Defined
UBS Securities LLC	24,856	$116,077	3.0%	Defined

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

$3,647,550

0.66%

781,060

BOOTHBAY FUND MANAGEMENT, LLC

$3,438,665

0.62%

736,331

VANGUARD PORTFOLIO MANAGEMENT LLC

$3,176,038

0.57%

680,094

VANGUARD FIDUCIARY TRUST CO

$2,844,711

0.51%

609,146

ExodusPoint Capital Management, LP

$2,709,510

0.49%

580,195

Velan Capital Investment Management LP

$2,661,900

0.48%

570,000

STEMPOINT CAPITAL LP

$2,445,436

0.44%

523,648

Rockefeller Capital Management L.P.

$2,315,465

0.42%

495,817

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
ROCKEFELLER FINANCIAL LLC	495,817	$2,315,465	100.0%	Defined

Nuveen, LLC

$2,260,325

0.41%

484,010

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Nuveen Asset Management, LLC joint	30,520	$142,528	6.3%	Defined
TIAA CREF INVESTMENT MANAGEMENT LLC joint	228,720	$1,068,122	47.3%	Defined
TEACHERS ADVISORS, LLC joint	224,770	$1,049,675	46.4%	Defined

WELLS FARGO & COMPANY/MN

$2,114,113

0.38%

452,701

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
WELLS FARGO BANK N A	174,621	$815,480	38.6%	Defined
WELLS FARGO ADVISORS FINANCIAL NETWORK, LLC	100,990	$471,623	22.3%	Defined
WELLS FARGO CLEARING SERVICES, LLC	177,090	$827,010	39.1%	Defined

Man Group plc

$1,908,386

0.34%

408,648

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Numeric Investors LLC	408,648	$1,908,386	100.0%	Defined

Squadron Capital Management LLC

$1,868,000

0.34%

400,000

PLATINUM INVESTMENT MANAGEMENT LTD

$1,796,857

0.32%

384,766

Seven Fleet Capital Management LP

$1,780,059

0.32%

381,169

Qube Research & Technologies Ltd

$1,730,487

0.31%

370,554

Atom Investors LP

$1,701,519

0.31%

364,351

Susquehanna Portfolio Strategies, LLC

$1,564,818

0.28%

335,079

ADAGE CAPITAL PARTNERS GP, L.L.C.

$1,517,750

0.27%

325,000

JANE STREET GROUP, LLC

$1,413,841

0.26%

302,750

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	271,340	$1,267,157	89.6%	Defined
Jane Street Global Trading, LLC	31,410	$146,684	10.4%	Defined

Connor, Clark & Lunn Investment Management Ltd.

$1,404,427

0.25%

300,734

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Manager 1	300,734	$1,404,427	100.0%	Sole

ADAR1 Capital Management, LLC

$1,363,439

0.25%

291,957

Invesco Ltd.

$1,355,354

0.24%

290,226

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Invesco Advisers, Inc. joint	12,318	$57,525	4.2%	Defined
Invesco Trust Co joint	40,410	$188,714	13.9%	Defined
Invesco Capital Management LLC	237,498	$1,109,115	81.8%	Defined

PANAGORA ASSET MANAGEMENT INC

$1,237,302

0.22%

264,947

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$1,210,931

0.22%

259,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	259,300	$1,210,931	100.0%	Other

LPL Financial LLC

$1,182,280

0.21%

253,165

Bank of New York Mellon Corp

$1,165,243

0.21%

249,517

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Investments Corporation	87,800	$410,026	35.2%	Defined
The Bank of New York Mellon	161,716	$755,213	64.8%	Defined
Held directly	1	$4	0.0%	Defined

WELLINGTON MANAGEMENT GROUP LLP

$1,063,675

0.19%

227,768

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Wellington Management Company LLP	72,973	$340,783	32.0%	Defined
Wellington Trust Company, NA joint	145,208	$678,121	63.8%	Defined
Wellington Management Australia Pty Ltd	9,587	$44,771	4.2%	Defined

MARSHALL WACE, LLP

$1,060,103

0.19%

227,003

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Marshall Wace North America L.P. joint	227,003	$1,060,103	100.0%	Other

MILLENNIUM MANAGEMENT LLC

$1,005,852

0.18%

215,386

Jump Financial, LLC

$853,209

0.15%

182,700

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Leap GP LLC joint	182,700	$853,209	100.0%	Defined

Caption Management, LLC

$825,656

0.15%

176,800

Point72 Asset Management, L.P.

$812,416

0.15%

173,965

Squarepoint Ops LLC

$797,794

0.14%

170,834

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Squarepoint Capital LLP	170,834	$797,794	100.0%	Defined

PRICE T ROWE ASSOCIATES INC /MD/

$727,964

0.13%

155,881

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
T. Rowe Price International Ltd	155,881	$727,964	100.0%	Defined

Headlands Technologies LLC

$719,049

0.13%

153,972

AMERICAN CENTURY COMPANIES INC

$703,680

0.13%

150,681

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
AMERICAN CENTURY INVESTMENT MANAGEMENT INC	150,681	$703,680	100.0%	Defined

XTX Topco Ltd

$632,495

0.11%

135,438

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
XTX EXECUTION SERVICES LLC joint	135,438	$632,495	100.0%	Defined

Palumbo Wealth Management LLC

$618,387

0.11%

132,417

RHUMBLINE ADVISERS

$615,865

0.11%

131,877

BRIDGEWAY CAPITAL MANAGEMENT, LLC

$612,237

0.11%

131,100

Walleye Capital LLC

$537,633

0.10%

115,125

ALPS ADVISORS INC

$524,039

0.09%

112,214

CANADA PENSION PLAN INVESTMENT BOARD

$474,005

0.09%

101,500

DEUTSCHE BANK AG\

$461,736

0.08%

98,873

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
DWS Investments UK Ltd	98,873	$461,736	100.0%	Defined

Virtu Financial LLC

$458,098

0.08%

98,094

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Virtu Americas LLC	98,094	$458,098	100.0%	Defined

Verition Fund Management LLC

$443,650

0.08%

95,000

Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group

$396,950

0.07%

85,000

BARCLAYS PLC

$347,988

0.06%

74,516

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
BARCLAYS BANK PLC	60,697	$283,454	81.5%	Defined
BARCLAYS CAPITAL INC.	13,819	$64,534	18.5%	Defined

BNP PARIBAS ARBITRAGE, SA

$347,321

0.06%

74,373

CITADEL ADVISORS LLC

$336,707

0.06%

72,100

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citadel Securities GP LLC	72,100	$336,707	100.0%	Defined

Crestwood Advisors Group, LLC

$310,722

0.06%

66,536

CV Advisors LLC

$303,550

0.05%

65,000

INTREPID FAMILY OFFICE LLC

$303,550

0.05%

65,000

ALLIANCEBERNSTEIN L.P.

$302,522

0.05%

64,780

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Equitable Holdings, Inc.	64,780	$302,522	100.0%	Defined

MetLife Investment Management, LLC

$286,705

0.05%

61,393

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
METLIFE INC	61,393	$286,705	100.0%	Defined

Jain Global LLC

$268,814

0.05%

57,562

Thrivent Financial for Lutherans

$246,402

0.04%

52,763

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Thrivent Asset Management, LLC	20,477	$95,627	38.8%	Defined
Held directly	32,286	$150,775	61.2%	Sole

JANE STREET GROUP, LLC

$234,901

0.04%

50,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Jane Street Capital, LLC	50,300	$234,901	100.0%	Defined

CITIGROUP INC

$230,645

0.04%

49,389

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Citigroup Financial Products Inc. joint	49,389	$230,645	100.0%	Defined

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

$217,033

0.04%

46,474

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Global X Management CO LLC joint	46,474	$217,033	100.0%	Defined

SEI INVESTMENTS CO

$197,895

0.04%

42,376

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SEI TRUST CO	42,376	$197,895	100.0%	Sole

SUSQUEHANNA INTERNATIONAL GROUP, LLP

$178,861

0.03%

38,300

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
SUSQUEHANNA SECURITIES, LLC	38,300	$178,861	100.0%	Other

Quadrature Capital Ltd

$171,510

0.03%

36,726

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Quadrature US Inc.	36,726	$171,510	100.0%	Other

Caption Management, LLC

$163,450

0.03%

35,000

Vanguard Global Advisers, LLC

$157,995

0.03%

33,832

Dynamic Technology Lab Private Ltd

$153,306

0.03%

32,828

PRUDENTIAL FINANCIAL INC

$145,867

0.03%

31,235

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
PGIM Quantitative Solutions LLC	31,235	$145,867	100.0%	Defined

Police & Firemen's Retirement System of New Jersey

$139,600

0.03%

29,893

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
Mellon Capital	29,893	$139,600	100.0%	Defined

MANUFACTURERS LIFE INSURANCE COMPANY, THE

$128,485

0.02%

27,513

This filing is a combination report: the position is filed across the managers below.

Manager	Shares	Value (USD)	% of position	Discretion
MANULIFE FINANCIAL CORP joint	27,513	$128,485	100.0%	Defined

JACOBS LEVY EQUITY MANAGEMENT, INC

$117,268

0.02%

25,111

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